Author: "Sable, Beate" - Searchworks@Jio Institute Digital Library Search Results

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Author: Serrano, Alejandra G., Rocha, Pedro, Freitas Lima, Cibelle, Stewart, Allison, Zhang, Bingnan, Diao, Lixia, Fujimoto, Junya, Cardnell, Robert J., Lu, Wei, Khan, Khaja, Sable, Beate, Ellison, Aaron R., Wistuba, Ignacio I., Concannon, Kyle F., Halperin, Daniel M., Bogdan, Czerniak, Sircar, Kanishka, Zhang, Miao, Cargill, Kasey, Wang, Qi, Aparicio, Ana, Lazar, Alexander, Hernandez, Sharia, Estrella, Jeannelyn, Ramalingam, Preetha, El-Naggar, Adel, Kalhor, Neda, Gay, Carl M., Byers, Lauren Averett, and Solis Soto, Luisa M.
Published: 2024
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Author: Zhou, Di, Byers, Lauren A., Sable, Beate, Smit, Marie‐Anne Damiette, Sadraei, Nooshin Hashemi, Dutta, Sandeep, and Upreti, Vijay V.
Subjects: TREATMENT of lung tumors, CELLULAR therapy, SMALL cell carcinoma, CELL receptors, CANCER relapse, TREATMENT effectiveness, CANCER patients, RESEARCH funding, IMMUNOTHERAPY, PATIENT safety
Abstract: With the promise of a potentially single‐dose curative regimen, CAR‐T cell therapies have brought a paradigm shift in the treatment and management of hematological malignancies with 6 approved products in the USA. However, there are no approved CAR‐T cell therapies for solid tumors. Herein, we report the clinical pharmacology profile of AMG 119, the first CAR‐T cell therapy targeting delta‐like ligand 3 (DLL3), in patients with relapsed/refractory (R/R) small cell lung cancer (SCLC). AMG 119 demonstrated robust cellular expansion with long‐lasting cell persistence and a favorable exposure–response relationship. AMG 119 has been demonstrated to be clinically safe and well tolerated at the doses tested, with no dose‐limiting toxicities (DLTs) reported. This is the first publication of the clinical pharmacology profile of a CAR‐T cell therapy in SCLC, with encouraging cellular kinetics data supporting the potential for CAR‐T cell therapy in solid tumor space. [ABSTRACT FROM AUTHOR]
Published: 2024
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Author: Trigos, Anna S., primary, Pasam, Anupama, additional, Inderjeeth, Andrisha-Jade, additional, Cain, Lachlan D., additional, Weng, Sirui, additional, Gupta, Vinita, additional, Sable, Beate, additional, Paweletz, Katherine L., additional, Bailis, Julie M., additional, Zhang, Yangyi, additional, Feng, Yuzhou, additional, Anton, Angelyn, additional, Tran, Ben, additional, Mitchell, Catherine, additional, and Sandhu, Shahneen, additional
Published: 2023
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Author: Pham, Elizabeth, primary, Henn, Anja, additional, Sable, Beate, additional, Wahl, Joachim, additional, Conner, Kip, additional, Matthes, Katja, additional, Gupta, Shivani, additional, Yabut, Rodolfo, additional, Aeffner, Famke, additional, Wilson, Kristin Lewis, additional, Anlahr, Jonas, additional, Dahlhoff, Christoph, additional, Kale, Vijay, additional, Friedrich, Matthias, additional, Raum, Tobias, additional, Kufer, Peter, additional, Coxon, Angela, additional, Stienen, Sabine, additional, and Bailis, Julie M., additional
Published: 2022
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Author: Lima, Cibelle F., primary, Rocha, Pedro S., additional, Fujimoto, Junya, additional, Stewart, Allison, additional, Cardnell, Robert, additional, Lu, Wei, additional, Khan, Khaja, additional, Sable, Beate, additional, Ellison, Aaron R., additional, Wistuba, Ignacio I., additional, Gay, Carl M., additional, Kalhor, Neda, additional, Byers, Lauren A., additional, and Solis-Soto, Luisa M., additional
Published: 2022
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Author: Loberg, Robert D, primary, Rossi, John M, additional, Manoukian, Raffi, additional, Wang, Shen-Wu, additional, Paweletz, Katherine L, additional, Sable, Beate, additional, Tudor, Yanyan, additional, Patterson, Scott D, additional, and McCaffery, Ian, additional
Published: 2011
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