46 results on '"Sablayrolles, C."'
Search Results
2. Environmental analysis of a domestic rainwater harvesting system: A case study in France
- Author
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Vialle, C., Busset, G., Tanfin, L., Montrejaud-Vignoles, M., Huau, M.-C., and Sablayrolles, C.
- Published
- 2015
- Full Text
- View/download PDF
3. Reactivity of nitrate and organic acids at the concrete–bitumen interface of a nuclear waste repository cell
- Author
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Bertron, A., Jacquemet, N., Erable, B., Sablayrolles, C., Escadeillas, G., and Albrecht, A.
- Published
- 2014
- Full Text
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4. Pesticides in roof runoff: Study of a rural site and a suburban site
- Author
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Vialle, C., Sablayrolles, C., Silvestre, J., Monier, L., Jacob, S., Huau, M.-C., and Montrejaud-Vignoles, M.
- Published
- 2013
- Full Text
- View/download PDF
5. Monitoring of water quality from roof runoff: Interpretation using multivariate analysis
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Vialle, C., Sablayrolles, C., Lovera, M., Jacob, S., Huau, M.-C., and Montrejaud-Vignoles, M.
- Published
- 2011
- Full Text
- View/download PDF
6. Water Quality Monitoring and Hydraulic Evaluation of a Household Roof Runoff Harvesting System in France
- Author
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Vialle, C., Sablayrolles, C., Lovera, M., Huau, M.-C., Jacob, S., and Montrejaud-Vignoles, M.
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- 2012
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- View/download PDF
7. Nitrate reducing bacterial activity in concrete cells of nuclear waste disposal
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Albrecht A., Rafrafi Y., Sablayrolles C., Bertron A., Kassim C., Alquier M., and Erable B.
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Physics ,QC1-999 - Abstract
Leaching experiments of solid matrices (bitumen and cement pastes) have been first implemented to define the physicochemical conditions that microorganisms are likely to meet at the bitumen-concrete interface (see the paper of Bertron et al.). Of course, as might be suspected, the cement matrix imposes highly alkaline pH conditions (10
- Published
- 2013
- Full Text
- View/download PDF
8. Physico-chemical interactions at the concrete-bitumen interface of nuclear waste repositories
- Author
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Sablayrolles C., Escadeillas G., Erable B., Jacquemet N., Ranaivomanana H., Bertron A., and Albrecht A.
- Subjects
Physics ,QC1-999 - Abstract
This study investigates the fate of nitrate and organic acids at the bitumenconcrete-steel interface within a repository storage cell for long-lived, intermediatelevel, radioactive wastes. The interface was simulated by a multiphase system in which cementitious matrices (CEM V-paste specimens) were exposed to bitumen model leachates consisting of nitrates and acetic acid with and without oxalic acid, chemical compounds likely to be released by bitumen. Leaching experiments were conducted with daily renewal of the solutions in order to accelerate reactions. C-steel chips, simulating the presence of steel in the repository, were added in the systems for some experiments. The concentrations of anions (acetate, oxalate, nitrate, and nitrite) and cations (calcium, potassium, ammonium) and the pH were monitored over time. Mineralogical changes of the cementitious matrices were analysed by XRD. The results confirmed the stability of nitrates in the absence of steel, whereas, reduction of nitrates was observed in the presence of steel (production of NH4+). The action of acetic acid on the cementitious matrix was similar to that of ordinary leaching; no specific interaction was detected between acetate and cementitious cations. The reaction of oxalic acid with the cementitious phases led to the precipitation of calcium oxalate salts in the outer layer of the matrix. The concentration of oxalate was reduced by 65% inside the leaching medium.
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- 2013
- Full Text
- View/download PDF
9. Contribution of car, truck, bus and subway wash station discharges to stormwater pollution (Toulouse, France)
- Author
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Breton, A., Claire VIALLE, Montrejaud-Vignoles, M., Cecutti, C., Vignoles, C., Sablayrolles, C., Ecole nationale supérieure des ingénieurs en arts chimiques et technologiques, Chimie Agro-Industrielle (CAI), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole nationale supérieure des ingénieurs en arts chimiques et technologiques-Institut National de la Recherche Agronomique (INRA), VEOLIA France, Institut National Polytechnique de Toulouse - INPT (FRANCE), Institut National de la Recherche Agronomique - INRA (FRANCE), Veolia Environnement (FRANCE), Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE), and ProdInra, Migration
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Ecologie, Environnement ,Separated sewage system ,[SPI.GPROC] Engineering Sciences [physics]/Chemical and Process Engineering ,education ,stormwater ,[SDV.IDA] Life Sciences [q-bio]/Food engineering ,Concentrations ,Water quality ,motor vehicle ,Autre ,Organic compounds ,[SDV.IDA]Life Sciences [q-bio]/Food engineering ,Run-off waters ,pollution ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering - Abstract
15th International Symposium on Environmental Pollution and its Impact on Life in the Mediterranean Region, OCT 07-11, 2009, Bari, Italy; International audience; The European Water Framework Directive requires the monitoring of priority pollutants entering surface waters. This includes notably the stormwater network. In this study, the contribution of discharges from wash stations to pollution of the stormwater network was investigated. Six wash stations discharging wastewater into the stormwater network were selected: (i) one trucks wash station, (ii) two self-service stations for cars and motorcycles, (iii) two bus wash stations, (iv) one subway wash station. Classical parameters (conductivity, pH, turbidity, chemical oxygen demand, total nitrogen, total phosphorus, suspended solid) and organic micropollutants (Polycyclic Aromatic Hydrocarbons (PAHs), Total Hydrocarbons (TH) and Methylterbutylether (MTBE)) were checked and measured. Concentrations were compared with limit values from Greater Toulouse decontamination service regulations for the discharge licenses of carwashes, and under the French decree for discharges into the natural environment and with the proposed directive from the European Parliament and the Council, dealing with environmental quality standards. The result showed a decrease of pollution downstream of the pre-treatments for subway wash stations but not for bus wash stations. According to the directives, the pre-treatment processes are not sufficient to justify a discharge into the stormwater network.
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- 2010
10. Life cycle analysis for the cultivation and combustion of Miscanthus for biofuel compared with natural gas
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Ashworth, A., West, C., Popp, M., Sablayrolles, C., Gabrielle, Benoit, environmental soil and water science., University Arkasnas, Department of Crop, Soil and Environmental Sciences., University of Arkansas [Fayetteville], Department of Agricultural Economics and Agribusiness, Ecole Nationale Supérieure des Ingénieurs en Arts Chimiques et Technologiques, Environnement et Grandes Cultures (EGC), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, and AgroParisTech-Institut National de la Recherche Agronomique (INRA)
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[SDV]Life Sciences [q-bio] - Abstract
revue avec comité de lecture national; As negative environmental and economic impacts of fossil fuels have escalated, so has the importance of renewable bioenergy crops whose feedstocks are noncompetitive with food supplies. Compared with fossil fuels, use of lignocellulosic feedstocks offers potential for greenhouse gas reduction and highly positive net energy returns because of low input demand and high yields per unit of land area, thus making them advantageous for the emerging biofuel industry. The aim of this study was to simulate environmental impacts of producing a biofuel grass for combustion use based on the inventory of inputs and their effects on eutrophication of surface waters; acidification of land and water; photochemical ozone-creation potential (i.e. smog); global atmospheric warming; and nonrenewable resource depletion (mainly fossil fuels). Hybrid miscanthus (Miscanthus x giganteus, or giant miscanthus), a perennial C4 grass originating from East Asia, was compared with natural gas by using a life-cycle analysis model for biomass production in France. The analysis showed a trade-off between natural gas and miscanthus. The latter had a lower global-warming potential and consumed less primary nonrenewable en ergy but produced more emissions that promote acidification and eutrophication than did natural gas.
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- 2008
11. Environmental impacts of biological management of organic waste
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Mallard, P., Gabrielle, B., Rogeau, Didier, Vial, E., Vignoles, Mireille, Sablayrolles, C., Carrère, Myriam, Renou, Sophie, Aoustin, E., Muller, Oceane, Pierre, N., Coppin, Yves, Gestion environnementale et traitement biologique des déchets (UR GERE), Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF), Institut National de la Recherche Agronomique (INRA), ECOBILAN NEUILLY SUR SEINE, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Chimie Agro-Industrielle (CAI), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole nationale supérieure des ingénieurs en arts chimiques et technologiques-Institut National de la Recherche Agronomique (INRA), CENTRE DE RECHERCHES SUR L'ENERGIE L'ENVIRONNEMENT ET LES DECHETS LIMAY, Anjou Recherche, Veolia Environnement (FRANCE), ORVAL RILLEUX LA PAPE, Agence de l'Environnement et de la Maîtrise de l'Energie (ADEME), and Irstea Publications, Migration
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[SDE] Environmental Sciences ,[SDE]Environmental Sciences - Abstract
Agricultural recycling of organic waste intuitively appears as environmentally-sound management in that it relies on natural biological processes and causes organic matter to return to soils. It has indeed emerged as a top priority in the French and European waste policy agendas. However, the environmental assessment of biological waste management routes raises challenging issues, whether dealing with the criteria that should be retained in the evaluation, or the characterisation of impacts themselves. There are many uncertainties associated with the latter. In that context, the scope of the study reported here was to review the current knowledge available to characterise the environmental and sanitary impacts attributable to the various biological waste disposal routes: animal manure, urban waste, sewage sludge, and agro-industrial or paper-mill waste. More specifically, the objective was to provide quantitative estimates of the factors causing the final impacts. These encompassed the consumption and emission of various substances and forms of energy involved in the management of organic waste, including the fate of nutriments and contaminants after the application of organic waste in the field. Micro-biological risks were not investigated to restrict an already considerably large scope. Overall, our literature review emphasised the great sensitivity of emissions to various treatment and environmental controls (eg, temperature or soil type), and also to substrate characteristics. The available knowledge appeared often too scant to tackle the ensuing variability, making it impossible to correctly describe and quantify the underlying processes. This knowledge gap may be bridged either by a more thorough understanding and modelling of these processes, or through the collection of new data under actual operating conditions. In a second stage, the reference data set obtained from the literature review was assembled in a format that could be readily used in a global evaluation such as life cycle assessment (LCA). Beyond the issue of data availability, accuracy and representativity, several methodological limitations to LCA were discussed, and recommendations made. Further considerations were given as to how to address odours and ecotoxicity impacts, and above all the influence of repeated organic waste application on soil fertility and quality, including carry over effects over the long term.
- Published
- 2005
12. Impacts environnementaux de la gestion biologique des déchets. Bilan des connaissances
- Author
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Mallard, P., Didier Rogeau, Gabrielle, B., Vial, E., Oceane Muller, Mireille Vignoles, Sablayrolles, C., Le Corff, V., Myriam Carrère, Sophie Renou, Pierre, N., Yves Coppin, Gestion environnementale et traitement biologique des déchets (UR GERE), Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF), Institut National de la Recherche Agronomique (INRA), ECOBILAN NEUILLY SUR SEINE, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Chimie Agro-Industrielle (CAI), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole nationale supérieure des ingénieurs en arts chimiques et technologiques-Institut National de la Recherche Agronomique (INRA), CENTRE DE RECHERCHES SUR L'ENERGIE L'ENVIRONNEMENT ET LES DECHETS LIMAY, Anjou Recherche, ORVAL RILLEUX LA PAPE, Agence de l'Environnement et de la Maîtrise de l'Energie (ADEME), irstea, and Irstea Publications, Migration
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[SDE] Environmental Sciences ,UTILISATION AGRICOLE ,[SDE]Environmental Sciences - Abstract
Agricultural recycling of organic waste intuitively appears as environmentally sound management in that it relies on natural biological processes and causes organic matter to return to soils. It has indeed emerged as a top priority in the French and European waste policy agendas. However, the environmental assessment of biological waste management routes raises challenging issues, whether dealing with the criteria that should be retained in the evaluation, or the characterisation of impacts themselves. There are many uncertainties associated with the latter. In that context, the scope of the study reported here was to review the current knowledge available to characterise the environmental and sanitary impacts attributable to the various biological waste disposal routes: animal manure, urban waste, sewage sludge, and agro-industrial or paper-mill waste. More specifically, the objective was to provide quantitative estimates of the factors causing the final impacts. These encompassed the consumption and emission of various substances and forms of energy involved in the management of organic waste, including the fate of nutriments and contaminants after the application of organic waste in the field. Microbiological risks were not investigated to restrict an already considerably large scope. Overall, our literature review emphasised the great sensitivity of emissions to various treatment and environmental controls (eg, temperature or soil type), and also to substrate characteristics. The available knowledge appeared often too scant to tackle the ensuing variability, making it impossible to correctly describe and quantify the underlying processes. This knowledge gap may be bridged either by a more thorough understanding and modelling of these processes, or through the collection of new data under actual operating conditions. In a second stage, the reference data set obtained from the literature review was assembled in a format that could be readily used in a global evaluation such as life cycle assessment (LCA). Beyond the issue of data availability, accuracy and representativity, several methodological limitations to LCA were discussed, and recommendations made. Further considerations were given as to how to address odours and ecotoxicity impacts, and above all the influence of repeated organic waste application on soil fertility and quality, including carry over effects over the long term., La valorisation organique apparaît intuitivement comme un mode de gestion des déchets respectueux de l'environnement, car mettant en ½uvre des phénomènes biologiques « naturels » et permettant le « retour au sol » de la matière organique. Elle est d'ailleurs une des priorités de la politique des déchets au niveau français aussi bien qu'européen. Pourtant, l'évaluation environnementale des filières de gestion biologique des déchets se révèle difficile, tant sur le choix des critères d'évaluation à prendre en compte que sur la quantification des impacts, sur laquelle pèsent de nombreuses incertitudes. Devant ce constat, l'objet de la présente étude était de faire le point des connaissances disponibles ou manquantes pour l'appréciation des impacts environnementaux et sanitaires potentiels attribuables aux différentes filières de gestion biologique : déjections animales, biodéchets ménagers et assimilés, boues d'épuration et résidus agro-industriels ou papetiers. Il s'agissait, plus précisément, de proposer autant que possible une quantification, non des impacts proprement dits, mais des facteurs à l'origine de ces impacts, à savoir concrètement les différentes consommations ou rejets de substances ou d'énergie liés à la gestion biologique des déchets, y compris le devenir des éléments nutritifs et des contaminants apportés au sol lors de l'épandage des produits organiques. Par souci de ne pas trop étendre le champ de l'étude, la question des risques microbiologiques a été laissée de côté. Sans entrer dans le détail des résultats, il ressort du travail bibliographique réalisé une grande sensibilité des différents facteurs d'impact aux conditions de traitement ou de milieu (température, type de sol) et à la nature des substrats. Face à la variabilité qui en découle, les connaissances disponibles apparaissent souvent trop partielles pour décrire et quantifier correctement les phénomènes considérés. Les besoins de connaissances identifiés relèvent soit de la compréhension et de la modélisation des phénomènes, soit de l'acquisition de nouvelles données en conditions réelles. Dans une seconde phase, les données de référence issues de la bibliographie ont été présentées et adaptées sous une forme qui puisse être exploitable directement dans le cadre d'évaluations environnementales du type analyse de cycle de vie. Au-delà du problème de la disponibilité des données, de leur précision et de leur représentativité, différentes limitations méthodologiques de l'analyse de cycle de vie pour l'évaluation environnementale des filières biologiques ont été discutées, des recommandations formulées ou des pistes d'amélioration proposées. La réflexion a porté ainsi sur la prise en compte des nuisances olfactives, de l'écotoxicité, et surtout de l'incidence de l'épandage de produits organique sur la qualité du sol et son pouvoir fertilisant, y compris les phénomènes d'arrière-effets.
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- 2005
13. Quantification of environmental effects due to the biological treatment and land use of organic fertilizers - state of knowledge
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Mallard, P., Gabrielle, B., Vial, E., Rogeau, Didier, Vignoles, Mireille, Sablayrolles, C., Carrère, Myriam, Renou, Sophie, Pierre, N., Muller, Oceane, Coppin, Yves, Gestion environnementale et traitement biologique des déchets (UR GERE), Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF), Institut National de la Recherche Agronomique (INRA), ECOBILAN NEUILLY SUR SEINE, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Chimie Agro-Industrielle (CAI), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole nationale supérieure des ingénieurs en arts chimiques et technologiques-Institut National de la Recherche Agronomique (INRA), CENTRE DE RECHERCHES SUR L'ENERGIE L'ENVIRONNEMENT ET LES DECHETS LIMAY, Anjou Recherche, ORVAL RILLEUX LA PAPE, Agence de l'Environnement et de la Maîtrise de l'Energie (ADEME), and Irstea Publications, Migration
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[SDE] Environmental Sciences ,[SDE]Environmental Sciences - Abstract
L'utilisation agricole des déchets ou produits organiques (dont les déjections animales, les boues et les composts) apparaît intuitivement comme un mode de gestion respectueux de l'environnement, car mettant en oeuvre des phénomènes biologiques « naturels » et permettant le « retour au sol » de la matière organique. Pourtant, la démonstration de ce bien-fondé environnemental se révèle difficile, tant sur le choix des critères à prendre en compte que sur la quantification des impacts environnementaux et sanitaires associés potentiellement aux filières de gestion biologique. Afin de contribuer à l'amélioration des pratiques en la matière, nous avons fait le point des connaissances disponibles ou manquantes permettant la quantification, non de ces impacts à proprement parler, mais des différents rejets et consommations de substances et d'énergie qui en sont à l'origine. Sur la base d'une large revue bibliographique, des fourchettes de valeurs pour les différents facteurs d'impacts ont pu être proposées, concernant chacune des étapes de la filière : stockage, traitement, épandage et devenir ultérieur des produits dans le sol. Sans entrer dans le détail des résultats, il apparaît une grande sensibilité des facteurs d'impact à la nature des produits ainsi qu'aux conditions de traitement et de milieu (température, type de sol), face à laquelle les connaissances disponibles s'avèrent souvent trop partielles. Les besoins identifiés relèvent de l'acquisition de nouvelles données en conditions réelles, ou bien de la compréhension et de la modélisation des phénomènes mis en jeu.
- Published
- 2005
14. Performances des stations de pompages en irrigation : application aux forages de petits périmètres irrigués de la plaine de Kairouan (Tunisie) et impact des dysfonctionnements sur le prix de l'eau
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Luc, J.P., Tarhouni, J., Calvez, R., Liman, M., Sablayrolles, C., Institut National Agronomique de Tunisie (INAT), Ministère de la recherche, Ali Hammani, Marcel Kuper, Abdelhafid Debbarh, Kuper, Marcel, and Ali Hammani, Marcel Kuper, Abdelhafid Debbarh
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[SDV.SA]Life Sciences [q-bio]/Agricultural sciences ,[SDV.SA] Life Sciences [q-bio]/Agricultural sciences - Abstract
International audience; Lorsqu'une élévation de l'eau de nappes ou une mise en pression est nécessaire au fonctionnement des systèmes modernes d'irrigation dans un périmètre, on utilise presque exclusivement des pompes centrifuges. La facture énergétique représente donc une part importante du coût de l'eau. Or, le rendement de ces machines est très dépendant de leurs conditions de fonctionnement et de leur usure et toute déviation par rapport aux conditions optimales entraîne des surcoûts énergétiques importants. L'objectif est de proposer une méthodologie pour évaluer les performances de ces équipements. Des indicateurs accessibles (énergie unitaire, énergie volumique absorbée réelle, volume spécifique pompé, coefficient de volume spécifique pompé) sont définis et des valeurs de référence fournies à partir des données des constructeurs. Les différentes méthodes d'estimation des volumes pompés sont critiquées. Les tests proposés sur les données volumiques indiquent le type de mesure réalisé pour les volumes pompés ainsi que leur dérive dans le temps (utilisation du débit nominal, compteur volumétrique). Pour les mesures d'énergie, l'absence de synchronisation entre les relevés temporels et énergétiques implique de cumuler les données pour obtenir la puissance consommée - lors de conditions stables de fonctionnement des pompes et si chaque pompe dispose d'un compteur d'énergie. Un ensemble de 18 stations de pompage sur forage alimentant des petits périmètres irrigués de la plaine de Kairouan en Tunisie centrale a été testé. La vétusté des équipements peut engendrer des rendements très faibles dont la conséquence principale est une augmentation des coûts de pompage (consommation énergétique et surcoût de maintenance). Ce diagnostic met donc bien en évidence l'intérêt d'un suivi précis de chaque ouvrage. Les divergences observées dans les ratios entre les volumes pompés et l'énergie consommée par rapport à ceux attendus en conditions optimales de fonctionnement conduisent au raisonnement suivant : si les données obtenues sont justes, le dysfonctionnement provient de l'inadaptation de l'équipement hydroélectrique au fonctionnement hydraulique de l'installation ; ou bien si les données sont fausses, ce dysfonctionnement provient des erreurs de gestion des pompistes et les quantités d'eau pompées sont alors sous-estimées. Dans les deux cas, un surcoût est payé par l'Administration. Dans la moitié des stations, les surcoûts d'énergie dépassent 20 %, voire 50 % pour près du quart d'entre elles.
- Published
- 2004
15. Impact of dry weather discharges on annual pollution from a separate storm sewer in Toulouse, France
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Deffontis, S., primary, Breton, A., additional, Vialle, C., additional, Montréjaud-Vignoles, M., additional, Vignoles, C., additional, and Sablayrolles, C., additional
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- 2013
- Full Text
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16. Récupération des eaux de pluie en aval des toitures pour une réutilisation dans l’habitat collectif et privatif
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Vialle, C., primary, Sablayrolles, C., additional, Lovera, M., additional, Huau, M.-C., additional, Jacob, S., additional, and Montrejaud-vignoles, M., additional
- Published
- 2013
- Full Text
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17. Caractérisation de la pollution des eaux de temps de pluie et de temps sec issues du réseau pluvial séparatif de la ville de Toulouse
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Deffontis, S., primary, Breton, A., additional, Vialle, C., additional, Montrejaud-Vignoles, M., additional, Vignoles, C., additional, and Sablayrolles, C., additional
- Published
- 2013
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18. Catalyse biotique et abiotique de la réduction des nitrates en milieu alcalin dans le contexte du stockage profond des déchets radioactifs
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Bertron, A., primary, Erable, B., additional, Alquier, M., additional, Jacquemet, N., additional, Kassim, C., additional, Sablayrolles, C., additional, Albasi, C., additional, Basseguy, R., additional, Strehaiano, P., additional, Vignoles, M., additional, Albrecht, A., additional, and Escadeillas, G., additional
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- 2013
- Full Text
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19. Physico-chemical interactions at the concrete-bitumen interface of nuclear waste repositories
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Bertron, A., primary, Ranaivomanana, H., additional, Jacquemet, N., additional, Erable, B., additional, Sablayrolles, C., additional, Escadeillas, G., additional, and Albrecht, A., additional
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- 2013
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20. Nitrate reducing bacterial activity in concrete cells of nuclear waste disposal
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Alquier, M., primary, Kassim, C., additional, Bertron, A., additional, Rafrafi, Y., additional, Sablayrolles, C., additional, Albrecht, A., additional, and Erable, B., additional
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- 2013
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21. Priority organic pollutants in the urban water cycle (Toulouse, France)
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Sablayrolles, C., primary, Breton, A., primary, Vialle, C., primary, Vignoles, C., primary, and Montréjaud-Vignoles, M., primary
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- 2011
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22. Modelling of a roof runoff harvesting system: the use of rainwater for toilet flushing
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Vialle, C., primary, Sablayrolles, C., primary, Lovera, M., primary, Huau, M.-C., primary, and Montréjaud-Vignoles, M., primary
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- 2011
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23. Impact of carwash discharge on stormwater quality (Toulouse, France)
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Sablayrolles, C., primary, Vialle, C., primary, Vignoles, C., primary, and Montrejaud-Vignoles, M., primary
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- 2010
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24. Reconstructing historical trends of polycyclic aromatic hydrocarbon deposition in a remote area of Spain using herbarium moss material
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Foan, L., primary, Sablayrolles, C., additional, Elustondo, D., additional, Lasheras, E., additional, González, L., additional, Ederra, A., additional, Simon, V., additional, and Santamaría, J.M., additional
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- 2010
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25. SAND TO ROOT TRANSFER OF PAHS AND PCBS BY CARROTS GROWN ON SAND WITH PURE SUBSTANCES AND BIOSOLIDS AMENDED SAND
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Sablayrolles, C., primary, Montréjaud-Vignoles, M., additional, Silvestre, J., additional, and Patria, L., additional
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- 2006
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26. ChemInform Abstract: Synthesis and Antibronchospastic Activity of 8‐Alkoxy‐ and 8‐( Alkylamino)imidazo(1,2‐a)pyrazines.
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BONNET, P. A., primary, MICHEL, A., additional, LAURENT, F., additional, SABLAYROLLES, C., additional, RECHENCQ, E., additional, MANI, J. C., additional, BOUCARD, M., additional, and CHAPAT, J. P., additional
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- 1993
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27. The conformational analysis of cis-3,4-Dimethylcyclopentanone. I: the vibrational spectra.
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Sablayrolles, C., Granger, R., and Bardet, L.
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- 1976
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28. Imidazo[1,2-a]pyrazine, bromo and methoxy derivatives: a 13C N.M.R. determination applied to nucleophilic substitution studies
- Author
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Bonnet, PA, Sablayrolles, C, and Chapat, JP
- Abstract
The 13C chemical shifts and coupling constants of imidazo[1,2-a]pyrazine and some of its derivatives are reported and compared with those of other series. These data enable us to study the nucleophilic substitution of 3,5-dibromoimidazo[1,2-alpyrazine and 6,8-dibromoimidazo[1,2-a]pyrazine by a methoxy group.
- Published
- 1984
- Full Text
- View/download PDF
29. Health risk assessment case study of trace metals in collected rainwater for domestic uses
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Busset, G., Claire VIALLE, Montréjaud-Vignoles, M., Huau, M., Jacob, S., Sablayrolles, C., Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE), Institut National de la Recherche Agronomique - INRA (FRANCE), Veolia Environnement (FRANCE), Centre d’Application et de Traitement des AgroRessources [Toulouse] (CRT CATAR), Chimie Agro-Industrielle (CAI), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole nationale supérieure des ingénieurs en arts chimiques et technologiques-Institut National de la Recherche Agronomique (INRA), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, VEOLIA EAU, Institut National Polytechnique de Toulouse - INPT (FRANCE), and ProdInra, Migration
- Subjects
Ecologie, Environnement ,roof run-off ,Greece ,[SPI.GPROC] Engineering Sciences [physics]/Chemical and Process Engineering ,Biodiversité et Ecologie ,Ingestion ,risk assessment ,Reuse ,[SDV.IDA] Life Sciences [q-bio]/Food engineering ,water quality ,reuse ,Heavy metals ,[SDV.IDA]Life Sciences [q-bio]/Food engineering ,ingestion ,Monte-carlo simulation ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,heavy metals ,Roof run-off ,monte-carlo simulation ,Risk assessment - Abstract
International audience; A health risk assessment methodology based on modelling with a Monte Carlo simulation was applied to harvested rainwater that could be used for domestic use in southern France. Firstly a pilot roof run-off collection system was installed and trace metals analysis in collected rainwater were developed. Next, a model of exposure was built based only on chronic ingestion of rainwater during domestic activities. For exposure scenarios, three type of population were investigated: infants, children, and adults. A fourth scenario was used to determine an average risk for an entire lifetime. A Monte Carlo simulation was carried out to assess uncertainty propagation. The preponderant trace metals in reused rainwater were zinc, iron, aluminium and copper, with average concentrations equal to 4.40x10(-1) mg.L(-1) 5.43x10(-2) mg.L(-1), 5.27x10(-2) mg.L(-1) and 2.06x10(-2) mg.L(-1), respectively. When maximum concentration values were used in calculations, hazard quotients did not exceed 6.4x10(-2), i.e., about 10% of the risk limit. The highest hazard quotients observed for a person during his or her entire lifespan were found for zinc (6.4x10(-2)) and lead (4.5x10(-2)). These health risk assessment results showed that no risk of non-carcinogenic effects from trace metals could be expected from the harvest and reuse of rainwater for domestic activities.
30. Emissions of polycyclic aromatic hydrocarbon particulates from combustion of different fuels
- Author
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Valérie Simon, Moreau, L., Romdhana, M. H., Sablayrolles, C., Montréjaud-Vignoles, M., Lecomte, D., Chimie Agro-Industrielle (CAI), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole nationale supérieure des ingénieurs en arts chimiques et technologiques-Institut National de la Recherche Agronomique (INRA), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, ADEME 'Agency for environment and energy management', Midi-Pyrenees region, Ingénierie Procédés Aliments (GENIAL), Institut National de la Recherche Agronomique (INRA)-AgroParisTech-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Ecole Nationale Supérieure des Ingénieurs en Arts Chimiques Et Technologiques (ENSIACET), INP - ENSIACET, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Centre de recherche d'Albi en génie des procédés des solides divisés, de l'énergie et de l'environnement (RAPSODEE), Centre National de la Recherche Scientifique (CNRS)-IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Centre National de la Recherche Scientifique - CNRS (FRANCE), Ecole nationale supérieure des Mines d'Albi-Carmaux - IMT Mines Albi (FRANCE), Institut National Polytechnique de Toulouse - INPT (FRANCE), Institut National de la Recherche Agronomique - INRA (FRANCE), ProdInra, Migration, Institut National de la Recherche Agronomique (INRA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-AgroParisTech-Conservatoire National des Arts et Métiers [CNAM] (CNAM), and Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
- Subjects
Air-dried sludge ,Oil shale ,PAHs ,[SPI.GPROC] Engineering Sciences [physics]/Chemical and Process Engineering ,Emissios ,[SDV]Life Sciences [q-bio] ,[SDV.IDA]Life Sciences [q-bio]/Food engineering ,emissions ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,[SDV.IDA] Life Sciences [q-bio]/Food engineering ,Fry-dried sludge ,Woody biomass ,Sciences agricoles - Abstract
International audience; The use of biomass as fuel for combustion allows partial replacement of fossil fuels and the reduction of fossil carbon dioxide emissions. Nevertheless, combustion of biomass waste may generate toxic pollutants such as Polycyclic Aromatic Hydrocarbons (PAHs) whose production is related to the combustion temperature, oxygen consumption and origin of the biomass fuel. In the present study, experimental protocols for biomass combustion and analytical quantification of PAHs were carried out. Six types of fuel were burned in a tubular reactor: two bio-solids dried differently (air drying and fry drying), oil-shale, used cooking oil (for recycling) and two types of woody biomass (oak and beech). The combustion tests were performed at 850 degrees C with fixed bed samples weighing about 1 g. The identification and quantification of PAHs in the particulate phase were performed by ultrasonic extraction followed by high-resolution gas chromatography coupled to low-resolution mass spectrometry. The 16 main EPA-classified PAHs have been identified. The results show that emissions of fry-dried sludge are approximately 5000 mu g g(-1), thus 10 times greater than those of wood and 10 times lower than those of used cooking oils. Toxicity of the particulate phase was essentially due to benzo(a)pyrene and benzo(b)fluoranthene.
31. ChemInform Abstract: Synthesis of Imidazol I ,2-a]pyrazine Derivatives with Uterine-Relaxing, Antibronchospastic and Cardiac-Stimulating Properties.
- Author
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SABLAYROLLES, C., primary, CROS, G. H., additional, MILHAVET, J. C., additional, RECHENQ, E., additional, CHAPAT, J.-P., additional, BOUCARD, M., additional, SERRANO, J. J., additional, and MCNEILL, J. H., additional
- Published
- 1984
- Full Text
- View/download PDF
32. ChemInform Abstract: N-NITRO AND N-NITROSO DERIVATIVES IN 5,6,7,8-TETRAHYDROIMIDAZO(1,2-A)PYRAZINE SERIES: SYNTHESIS AND DETERMINATION BY PROTON NMR SPECTROSCOPY OF THE Z- AND E-CONFIGURATIONS
- Author
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BONNET, P.-A., primary, SABLAYROLLES, C., additional, and CHAPAT, J.-P., additional
- Published
- 1984
- Full Text
- View/download PDF
33. ChemInform Abstract: SYNTHESIS AND ABSOLUTE CONFIGURATION OF (‐)‐TRANS(3R,4R)‐3,4‐DIMETHYLCYCLOHEXANONE
- Author
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MILHAVET, J.‐C., primary, SABLAYROLLES, C., additional, CHAPAT, J.‐P., additional, and GRANGER, R., additional
- Published
- 1978
- Full Text
- View/download PDF
34. ChemInform Abstract: ABSOLUTE CONFIGURATIONS OF (+)‐ AND (‐)‐CIS‐3,4‐DIMETHYLCYCLOHEXANONE. SYNTHESIS AND OPTICAL ROTARY DISPERSION STUDY
- Author
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MILHAVET, J.‐C., primary, SABLAYROLLES, C., additional, GIRARD, J.‐P., additional, and CHAPAT, J.‐P., additional
- Published
- 1980
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- View/download PDF
35. Structure du chloro-3 méthyl-2 4H-pyrazino[1,2-a]pyrimidinone-4. Erratum
- Author
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Sablayrolles, C., primary, Chapat, J. P., additional, Ducourant, B., additional, and Fourcade, R., additional
- Published
- 1987
- Full Text
- View/download PDF
36. ChemInform Abstract: IMIDAZO(1,2-A)PYRAZINE-2-CARBOXAMIDRAZONES: SYNTHESIS AND ANTIBACTERIAL ACTIVITY
- Author
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BONNET, P.-A., primary, SABLAYROLLES, C., additional, CHAPAT, J.-P., additional, SOULIE, B., additional, SIMEON DE BUOCHBERG, M., additional, DUSART, G., additional, and ATTISSO, M., additional
- Published
- 1984
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- View/download PDF
37. Structure du chloro-3 méthyl-2 4 H-pyrazino[1,2- a]pyrimidinone-4.
- Author
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Sablayrolles, C., Chapat, J. P., Ducourant, B., and Fourcade, R.
- Published
- 1987
- Full Text
- View/download PDF
38. Eco-Design of Thermopressing through Induction of 100% Coriander-Based Fiberboards: Optimization of Molding Conditions.
- Author
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Guaygua-Amaguaña P, Vaca-Medina G, Vialle C, Sablayrolles C, and Evon P
- Abstract
The hot pressing process for 100% coriander-based fiberboards was optimized using an induction RocTool system, which offers rapid mold heating and cooling. The fiberboards were made using deoiled press cake as a protein binder and extrusion-refined straw as reinforcement. Doehlert's experimental design was used to evaluate the influence of pressure (10-50 MPa), molding time (60-300 s), and mold temperature (155-205 °C) on fiberboard properties, energy consumption, cost, and environmental impact. The results showed that the RocTool device allows for better temperature control during shaping throughout the mold, resulting in mechanical properties that are both more homogeneous across the entire surface of the panel and, more importantly, substantially improved. Using the isoresponse curves, the optimal hot pressing conditions were 35 MPa, 300 s, and 205 °C, corresponding to a 40.6 MPa flexural strength. However, it was observed that to achieve an MDF-like fiberboard with minimal production costs, much less restrictive molding conditions were sufficient, i.e., 32.5 MPa, 170 s, and 160 °C. The study revealed that maximum thermopressing conditions emitted 3.87 kg of CO
2 eq ., while conditions leading to the MDF-like board reduced emissions to 1.45 kg CO2 eq ., resulting in a more environmentally friendly material.- Published
- 2024
- Full Text
- View/download PDF
39. Comparison of different twin-screw extraction conditions for the production of arabinoxylans.
- Author
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Jacquemin L, Mogni A, Zeitoun R, Guinot C, Sablayrolles C, Saulnier L, and Pontalier PY
- Subjects
- Chromatography, Ion Exchange, Sodium Hydroxide chemistry, Triticum, Ultrafiltration, Xylans isolation & purification
- Abstract
The aim of this article is to compare two different sets of optimal conditions for twin-screw extraction of xylans and define their influence on the purification steps, combining ultrafiltration and industrial chromatography. Two xylan extracts were obtained by twin-screw extrusion of straw and bran. Condition 1 used a high straw/bran ratio (equal to 6) and high sodium hydroxide content, and condition 2 used a lower straw/bran ratio (equal to 2) and low sodium hydroxide content. Arabinoxylan extraction yields are slightly higher for conditions with low straw content (5.1% versus 4.4%). Nevertheless, these recovery yields remain between 9% and 10%. Ultrafiltration is as efficient as evaporation for polysaccharide concentration, with lower energy consumption, but also demineralizes the solution. The combination of ultrafiltration and chromatography gives partial purification of the extract with a final arabinoxylan purity ranging from 16% to 26%. This is slightly higher than by direct precipitation, but limited because all the large molecules such as proteins and lignins were retained by ultrafiltration., (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
40. Halomonas desiderata as a bacterial model to predict the possible biological nitrate reduction in concrete cells of nuclear waste disposals.
- Author
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Alquier M, Kassim C, Bertron A, Sablayrolles C, Rafrafi Y, Albrecht A, and Erable B
- Subjects
- Biodegradation, Environmental, Biological Availability, Denitrification, Hydrogen-Ion Concentration, Oxidation-Reduction, Halomonas growth & development, Halomonas metabolism, Nitrates metabolism, Radioactive Waste prevention & control, Waste Disposal, Fluid methods
- Abstract
After closure of a waste disposal cell in a repository for radioactive waste, resaturation is likely to cause the release of soluble species contained in cement and bituminous matrices, such as ionic species (nitrates, sulfates, calcium and alkaline ions, etc.), organic matter (mainly organic acids), or gases (from steel containers and reinforced concrete structures as well as from radiolysis within the waste packages). However, in the presence of nitrates in the near-field of waste, the waste cell can initiate oxidative conditions leading to enhanced mobility of redox-sensitive radionuclides (RN). In biotic conditions and in the presence of organic matter and/or hydrogen as electron donors, nitrates may be microbiologically reduced, allowing a return to reducing conditions that promote the safety of storage. Our work aims to analyze the possible microbial reactivity of nitrates at the bitumen - concrete interface in conditions as close as possible to radioactive waste storage conditions in order (i) to evaluate the nitrate reaction kinetics; (ii) to identify the by-products (NO2(-), NH4(+), N2, N2O, etc.); and (iii) to discriminate between the roles of planktonic bacteria and those adhering as a biofilm structure in the denitrifying activity. Leaching experiments on solid matrices (bitumen and cement pastes) were first implemented to define the physicochemical conditions that microorganisms are likely to meet at the bitumen-concrete interface, e.g. highly alkaline pH conditions (10 < pH < 11) imposed by the cement matrix. The screening of a range of anaerobic denitrifying bacterial strains led us to select Halomonas desiderata as a model bacterium capable of catalyzing the reaction of nitrate reduction in these particular conditions of pH. The denitrifying activity of H. desiderata was quantified in a batch bioreactor in the presence of solid matrices and/or leachate from bitumen and cement matrices. Denitrification was relatively fast in the presence of cement matrix (<100 h) and 2-3 times slower in the presence of bituminous matrix (pH 9.7). The maximal rate of denitrification was approximately 0.063 mM h(-1) and some traces of nitrite were detected for a few hours (<2%). Overall, the presence of solid cement promoted the kinetics of denitrification. The inspection of the solid surfaces at the end of the experiment revealed the presence of a biofilm of H. desiderata on the cement paste surface. These attached bacteria showed a comparable denitrifying activity to planktonic bacterial culture. However, no colonization of bitumen was observed either by SEM or by epifluorescence microscopy., (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
41. Optimization of pressurized liquid extraction using a multivariate chemometric approach for the determination of anticancer drugs in sludge by ultra high performance liquid chromatography-tandem mass spectrometry.
- Author
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Seira J, Claparols C, Joannis-Cassan C, Albasi C, Montréjaud-Vignoles M, and Sablayrolles C
- Subjects
- Antineoplastic Agents isolation & purification, France, Linear Models, Multivariate Analysis, Pressure, Reproducibility of Results, Sensitivity and Specificity, Tandem Mass Spectrometry methods, Water Pollutants, Chemical isolation & purification, Antineoplastic Agents analysis, Chromatography, High Pressure Liquid methods, Liquid-Liquid Extraction methods, Sewage chemistry, Water Pollutants, Chemical analysis
- Abstract
The present paper describes an analytical method for the determination of 2 widely administered anticancer drugs, ifosfamide and cyclophosphamide, contained in sewage sludge. The method relies on the extraction from the solid matrix by pressurized liquid extraction, sample purification by solid-phase extraction and analysis by ultra high performance liquid chromatography coupled with tandem mass spectrometry. The different parameters affecting the extraction efficiency were optimized using an experimental design. Solvent nature was the most decisive factor for the extraction but interactions between some parameters also appeared very influent. The method was applied to seven different types of sludge for validation. The performances of the analytical method displayed high variability between sludges with limits of detection spanning more than one order of magnitude and confirming the relevance of multi-sample validation. Matrix effect has been determined as the most limiting analytical step for quantification with different extent depending on analyte and sludge nature. For each analyte, the use of deuterated standard spiked at the very beginning ensured the complete compensation of losses regardless of the sample nature. The suitability of the method between freshly spiked and aged samples has also been verified. The optimized method was applied to different sludge samples to determine the environmental levels of anticancer drugs. The compounds were detected in some samples reaching 42.5μg/kgDM in ifosfamide for the most contaminated sample., (Copyright © 2013 Elsevier B.V. All rights reserved.)
- Published
- 2013
- Full Text
- View/download PDF
42. Trace determination of linear alkylbenzene sulfonates: application in artificially polluted soil-carrots system.
- Author
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Sablayrolles C, Montréjaud-Vignoles M, Silvestre J, and Treilhou M
- Abstract
Surfactants are widely used in household and industrial products. The risk of incorporation of linear alkylbenzene sulfonates (LAS) from biosolids, wastewater, and fertilizers land application to the food chain is being assessed at present by the European Union. In the present work, a complete analytical method for LAS trace determination has been developed and successfully applied to LAS (C10-C13) uptake in carrot plants used as model. These carrots were grown in soil with the trace organics compounds added directly into the plant containers in pure substances form. LAS trace determination (mug kg(-1) dry matter) in carrots samples was achieved by Soxtec apparatus and high-performance liquid chromatography-fluorescence detection. The methodology developed provides LAS determination at low detection limits (5 mug kg(-1) dry matter) for carrot sample (2 g dry matter) with good recoveries rate (>90%). Transfer of LAS has been followed into the various parts of the carrot plant. LAS are generally found in the carrot leaves and percentage transfer remains very low (0.02%).
- Published
- 2009
- Full Text
- View/download PDF
43. Development and validation of methods for the trace determination of phthalates in sludge and vegetables.
- Author
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Sablayrolles C, Montréjaud-Vignoles M, Benanou D, Patria L, and Treilhou M
- Subjects
- Reference Standards, Gas Chromatography-Mass Spectrometry methods, Phthalic Acids analysis, Sewage chemistry, Vegetables chemistry
- Abstract
A routine method which is simple, quick and precise has been set up and validated for phthalate analysis in environmental samples (tomato plants and sewage sludges). Six phthalates have been studied simultaneously: dimethylphthalate, diethylphthalate, di-n-butylphthalate, n-butylbenzylphthalate, di-2-ethyl-hexyl phthalate (DEHP) and di-n-octylphthalate. Optimization of sample, solvent extraction uses a Soxtec apparatus and extract purification with an a solid-phase extraction cartridge allows between 90 and 110% recovery of phthalates. Precise, sensitive and selective identification and quantifying of analytes is by GC-MS in the single ion monitoring mode. This protocol allows analytes with concentrations as low as 10 microg/kg dry matter (DM) to be determined from small (1-2 g DM) samples. This analytical method has been applied to the phthalate transfer study for agricultural recycling of sludges, where phthalate bioavailability has been studied in aquiculture using two types of experiments. Tomatoes have been grown in containers where the trace organics have been directly introduced as pure substances, and in a second experiment under the same growth conditions, sewage sludge has replaced the pure substances. Transfer of these trace organics has been followed into the various parts of the tomato plant and in general only the DEHP is worthy of note although its percentage transfer remains very low even in an experiment designed to maximize this.
- Published
- 2005
- Full Text
- View/download PDF
44. Synthesis and antibronchospastic activity of 8-alkoxy- and 8-(alkylamino)imidazo[1,2-a]pyrazines.
- Author
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Bonnet PA, Michel A, Laurent F, Sablayrolles C, Rechencq E, Mani JC, Boucard M, and Chapat JP
- Subjects
- Animals, Bronchodilator Agents pharmacology, Imidazoles pharmacology, In Vitro Techniques, Male, Mice, Motor Activity drug effects, Phosphodiesterase Inhibitors pharmacology, Pyrazines pharmacology, Structure-Activity Relationship, Theophylline pharmacology, Bronchodilator Agents chemical synthesis, Imidazoles chemical synthesis, Pyrazines chemical synthesis
- Abstract
Theophylline still occupies a dominant place in asthma therapy. Unfortunately its adverse central nervous system (CNS) stimulant effects can dramatically limit its use, and adjustments in the dosage are often needed. We have synthesized a new series of imidazo[1,2-alpha]pyrazine derivatives which are much more potent bronchodilators than theophylline in vivo and do not exhibit the CNS stimulatory profile. In vitro studies on isolated rat uterus and guinea pig trachea confirm the high potentialities of these derivatives. 6-Bromo-8-(methylamino)imidazo[1,2-alpha]-pyrazine-3-carbonitrile (23) is identified as the most potent compound of the series. As in the case of theophylline, phosphodiesterase inhibition appears unlikely to be the unique mechanism of action of this series of heterocycles.
- Published
- 1992
- Full Text
- View/download PDF
45. Theophylline-like properties of xanthine analogs.
- Author
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Levallois C, Bonnafous JC, Francoise MA, Sablayrolles C, Chapat JP, and Mani JC
- Subjects
- 3',5'-Cyclic-AMP Phosphodiesterases antagonists & inhibitors, Adenosine analogs & derivatives, Adenosine pharmacology, Adenosine-5'-(N-ethylcarboxamide), Adenylyl Cyclases metabolism, Adult, Animals, Female, Humans, In Vitro Techniques, Male, Mice, Pyrazines pharmacology, Receptors, Cell Surface drug effects, Receptors, Purinergic, Thymidine metabolism, Theophylline pharmacology, Xanthines pharmacology
- Abstract
Theophylline and other methylxanthines display a large number of biological effects, some of which are clinically important. The effects of these compounds are commonly ascribed to an inhibition of cyclic AMP breakdown. However, it becomes actually evident that another mechanism, namely adenosine receptor antagonism, could be responsible for certain methylxanthine effects. It could be of interest to find new compounds displaying only one of these mechanisms, either phosphodiesterase inhibition or adenosine receptor antagonism. We have studied several synthetic imidazol[1,2a]pyrazines, some of which display theophylline-like pharmacological properties at lower doses than theophylline. We showed that some of these compounds inhibited mitogen-induced [3H]-thymidine uptake by human lymphocytes, which is consistent with increases in cyclic AMP levels: the most efficient compounds were those which were better phosphodiesterase inhibitors than theophylline and poorer adenosine receptor antagonists.
- Published
- 1984
- Full Text
- View/download PDF
46. Synthesis of imidazo[1,2-a]pyrazine derivatives with uterine-relaxing, antibronchospastic, and cardiac-stimulating properties.
- Author
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Sablayrolles C, Cros GH, Milhavet JC, Rechenq E, Chapat JP, Boucard M, Serrano JJ, and McNeill JH
- Subjects
- Animals, Atrial Function, Chemical Phenomena, Chemistry, Cyclic AMP metabolism, Dose-Response Relationship, Drug, Drug Interactions, Female, Guinea Pigs, Heart Rate drug effects, Imidazoles chemical synthesis, Isoproterenol pharmacology, Male, Myocardial Contraction drug effects, Propranolol pharmacology, Rats, Stimulation, Chemical, Structure-Activity Relationship, Bronchial Spasm drug therapy, Heart drug effects, Imidazoles pharmacology, Pyrazines pharmacology, Uterine Contraction drug effects
- Abstract
A series of imidazo[1,2-alpha]pyrazine derivatives was synthesized by condensation of alpha-halogenocarbonyl compounds and aminopyrazines. Various compounds resulted from competitive reactions or reagent isomerization and demonstrated in vitro uterine-relaxing and in vivo antibronchospastic activities. On isolated atria, 5-bromoimidazo-[1,2-alpha]pyrazine showed positive chronotropic and inotropic properties; the latter was associated with an increase in the cyclic AMP tissue concentration. Potentiation of the isoproterenol positive inotropic effect of 5-bromoimidazo[1,2-alpha]pyrazine and the lack of blockade of the 5-bromoimidazo[1,2-alpha]pyrazine positive inotropic effect by propranolol suggested phosphodiesterase-inhibiting properties.
- Published
- 1984
- Full Text
- View/download PDF
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