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2. Does stress response axis activation differ between patients with autoimmune disease and healthy people?

Author

Universidad de Alicante. Departamento de Psicología de la Salud, Montero-López, Eva, Peralta-Ramírez, María Isabel, Ortego-Centeno, Norberto, Sabio, José Mario, Callejas-Rubio, José Luis, Navarrete-Navarrete, Nuria, García-Ríos, M. Carmen, Santos-Ruiz, Ana, Universidad de Alicante. Departamento de Psicología de la Salud, Montero-López, Eva, Peralta-Ramírez, María Isabel, Ortego-Centeno, Norberto, Sabio, José Mario, Callejas-Rubio, José Luis, Navarrete-Navarrete, Nuria, García-Ríos, M. Carmen, and Santos-Ruiz, Ana

Abstract

Many studies have shown that patients with autoimmune disease present a hypoactive hypothalamic-pituitary-adrenal (HPA) axis, but the results are controversial. Our objective was to study differences in stress response axis activity between patients with autoimmune disease and healthy people. The study sample consisted of 97 women divided into four groups: 37 healthy women (HW), 21 with systemic lupus erythematosus (SLE), 21 with Sjögren's syndrome (SS), and 18 with systemic sclerosis (SSc). After being exposed to a stress task, participants' skin conductance and salivary cortisol levels were measured in order to assess their response to psychological stress. Diurnal cortisol concentrations were assessed by measuring salivary cortisol in samples collected five times over one day. In addition, self-administered questionnaires were used to assess psychological variables. A time × group interaction effect was found (p = 0.003) in salivary cortisol secretion in response to stressful challenge. The healthy group presented normal activation, the SS and SLE groups showed no activation, and the SSc group presented a similar activation pattern to the HW group, except at the time of recovery. Total cortisol production (AUCg) was higher in the SSc group than in the HW group (p = 0.001). Differences were also observed in the cortisol AUCg collected over one day between healthy women and patients with SLE (p = 0.004) as well as with SSc (p = 0.001): women with SLE and SSc presented higher total hormone production than healthy women. Patients with autoimmune disease present a different HPA axis response, which may contribute to the harmful effects of stress in these diseases.

Published
2024

3. Does stress response axis activation differ between patients with autoimmune disease and healthy people?

Author

Montero‐López, Eva, Peralta‐Ramírez, María Isabel, Ortego‐Centeno, Norberto, Sabio, José Mario, Callejas‐Rubio, José Luis, Navarrete‐Navarrete, Nuria, García‐Ríos, M. Carmen, and Santos‐Ruiz, Ana

Subjects
RESEARCH funding, QUESTIONNAIRES, PSYCHOLOGY of women, SYSTEMIC lupus erythematosus, HYDROCORTISONE, SELF medication, PSYCHOLOGICAL stress, AUTOIMMUNE diseases, SYSTEMIC scleroderma, CONVALESCENCE, SJOGREN'S syndrome, COMPARATIVE studies, SALIVA
Abstract

Many studies have shown that patients with autoimmune disease present a hypoactive hypothalamic‐pituitary‐adrenal (HPA) axis, but the results are controversial. Our objective was to study differences in stress response axis activity between patients with autoimmune disease and healthy people. The study sample consisted of 97 women divided into four groups: 37 healthy women (HW), 21 with systemic lupus erythematosus (SLE), 21 with Sjögren's syndrome (SS), and 18 with systemic sclerosis (SSc). After being exposed to a stress task, participants' skin conductance and salivary cortisol levels were measured in order to assess their response to psychological stress. Diurnal cortisol concentrations were assessed by measuring salivary cortisol in samples collected five times over one day. In addition, self‐administered questionnaires were used to assess psychological variables. A time × group interaction effect was found (p = 0.003) in salivary cortisol secretion in response to stressful challenge. The healthy group presented normal activation, the SS and SLE groups showed no activation, and the SSc group presented a similar activation pattern to the HW group, except at the time of recovery. Total cortisol production (AUCg) was higher in the SSc group than in the HW group (p = 0.001). Differences were also observed in the cortisol AUCg collected over one day between healthy women and patients with SLE (p = 0.004) as well as with SSc (p = 0.001): women with SLE and SSc presented higher total hormone production than healthy women. Patients with autoimmune disease present a different HPA axis response, which may contribute to the harmful effects of stress in these diseases. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Association of a rare variant of the TNFSF13B gene with susceptibility to Rheumatoid Arthritis and Systemic Lupus Erythematosus

Author

González-Serna, David, Ortiz-Fernández, Lourdes, Vargas, Sofía, García, Antonio, Raya, Enrique, Fernández-Gutierrez, Benjamín, López-Longo, Francisco Javier, Balsa, Alejandro, González-Álvaro, Isidoro, Narvaez, Javier, Gómez-Vaquero, Carmen, Sabio, José Mario, García-Portales, Rosa, González-Escribano, María Francisca, Tolosa, Carles, Carreira, Patricia, Kiemeney, Lambertus, Coenen, Marieke J. H., Witte, Torsten, Schneider, Matthias, González-Gay, Miguel Ángel, and Martín, Javier

Published
2018
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10. A combined large-scale meta-analysis identifies COG6 as a novel shared risk locus for rheumatoid arthritis and systemic lupus erythematosus

Author

Márquez, Ana, Vidal-Bralo, Laura, Rodríguez-Rodríguez, Luis, González-Gay, Miguel A, Balsa, Alejandro, González-Álvaro, Isidoro, Carreira, Patricia, Ortego-Centeno, Norberto, Ayala-Gutiérrez, María M, García-Hernández, Francisco José, González-Escribano, M Francisca, Sabio, José Mario, Tolosa, Carles, Suárez, Ana, González, Antonio, Padyukov, Leonid, Worthington, Jane, Vyse, Timothy, Alarcón-Riquelme, Marta E, and Martín, Javier

Published
2017
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15. Relative Handgrip Strength as Marker of Cardiometabolic Risk in Women with Systemic Lupus Erythematosus

Author

Sola-Rodríguez, Sergio, primary, Vargas-Hitos, José Antonio, additional, Gavilán-Carrera, Blanca, additional, Rosales-Castillo, Antonio, additional, Sabio, José Mario, additional, Hernández-Martínez, Alba, additional, Martínez-Rosales, Elena, additional, Ortego-Centeno, Norberto, additional, and Soriano-Maldonado, Alberto, additional

Published
2021
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16. Heart Rate Variability in Women with Systemic Lupus Erythematosus: Association with Health-Related Parameters and Effects of Aerobic Exercise

Author

Martínez-Rosales, Elena, primary, Sola-Rodríguez, Sergio, additional, Vargas-Hitos, José Antonio, additional, Gavilán-Carrera, Blanca, additional, Rosales-Castillo, Antonio, additional, Hernández-Martínez, Alba, additional, Artero, Enrique G., additional, Sabio, José Mario, additional, and Soriano-Maldonado, Alberto, additional

Published
2020
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20. Effects of 12-week aerobic exercise on patient-reported outcomes in women with systemic lupus erythematosus.

Author

Gavilán-Carrera, Blanca, Vargas-Hitos, José Antonio, Morillas-de-Laguno, Pablo, Rosales-Castillo, Antonio, Sola-Rodríguez, Sergio, Callejas-Rubio, José Luis, Sabio, José Mario, and Soriano-Maldonado, Alberto

Subjects
AEROBIC capacity, AEROBIC exercises, TIME, CARDIOPULMONARY fitness, HEALTH outcome assessment, MENTAL health, MENTAL depression, SYSTEMIC lupus erythematosus, FATIGUE (Physiology), PSYCHOLOGICAL stress
Abstract

To evaluate the effects of aerobic exercise on patient-reported outcomes (PROs) in women with systemic lupus erythematosus (SLE), and whether changes in cardiorespiratory fitness (CRF) mediate the changes in PROs. A total of 58 women with SLE were assigned to either an exercise group (EG; n = 26) or a control group (CG; n = 32) in this non-randomized clinical trial. The EG comprised 12 weeks of aerobic exercise (2 sessions/week) between 40%-75% of the individual's heart rate reserve. At baseline, and at week 12, CRF (Bruce test) and PROs were assessed including psychological stress (Perceived Stress Scale), sleep quality (Pittsburg Sleep Quality Index), fatigue (Multidimensional Fatigue Inventory), depressive symptoms (Beck Depression Inventory), and quality of life (36-item Short-Form Health Survey). In comparison to the CG, the EG showed a significant reduction in general fatigue (mean difference (MD) −2.86 units; 95%CI −5.70 to −0.01; p = 0.049), physical fatigue (MD −4.33 units; 95%CI −7.02 to −1.65; p = 0.002) and a non-significant reduction of reduced motivation (MD − 1.29 units; 95%CI −2.60 to 0.03; p = 0.055). There were no significant between-group differences in the changes in psychological stress, sleep quality, depressive symptoms, quality of life, or other fatigue dimensions (all p > 0.05). Changes in CRF mediated the effects of the exercise intervention on general fatigue by 53.8%. The results suggest that 12 weeks of progressive aerobic exercise might improve relevant dimensions of fatigue in women with SLE, despite the absence of effects on other PROs. Improvements in CRF seem to mediate the effect of exercise on general fatigue. Aerobic exercise could be safely introduced in rehabilitation programs for inactive patients with SLE with mild disease activity. Including physical activity recommendations as part of rehabilitation could improve relevant aspects of fatigue in women with SLE. When rehabilitation aims at reducing fatigue, cardiorespiratory fitness improvements derived from physical activity might enhance benefits. [ABSTRACT FROM AUTHOR]

Published
2022
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23. Association of physical fitness components and health-related quality of life in women with systemic lupus erythematosus with mild disease activity

Author

Gavilán Carrera, Blanca, García da Silva, Jaqueline, Vargas-Hitos, José Antonio, Sabio, José Mario, Morillas de Laguno, Pablo, Ríos Fernández, Raquel, and Soriano‑Maldonado, Alberto

Subjects
skin and connective tissue diseases
Abstract

To study the association of different components of physical fitness [flexibility, muscle strength and cardiorespiratory fitness (CRF)] and a clustered fitness score with healthrelated quality of life (HRQoL) in women with systemic lupus erythematosus (SLE) and to analyze whether participants with high fitness level have better HRQoL. This cross-sectional study included 70 women with SLE (aged 42.5; SD 13.9 years). The back-scratch test assessed flexibility, the 30-sec chair stand and handgrip strength tests assessed muscle strength, and the 6-min walk test (n = 49) assessed CRF. HRQoL was assessed through the 36-item Short-Form Health Survey (SF-36). Our study suggests that muscle strength and CRF are positively associated with HRQoL, while flexibility showed contradictory results. These findings highlight the importance of maintaining adequate fitness levels in women with SLE., This work was supported by the Consejería de Salud, Junta de Andalucía (grant number: PI-0525-2016) and the Ilustre Colegio Oficial de Médicos de Granada (Premios de Investigación 2017). BG-C was supported by the Spanish Ministry of Education (FPU15/00002).

Published
2019

24. Association between perceived level of stress, clinical characteristics and psychopathological symptoms in women with systemic lupus erythematosus

Author

Peralta-Ramírez, María Isabel, Pérez-Mármol, José Manuel, Castañeda-Cabestany, Margarita, Santos-Ruiz, Ana, Montero-López, Eva, Callejas-Rubio, José Luis, Navarrete-Navarrete, Nuria, Fernández-Sánchez, José Carlos, Jiménez-Alonso, Juan Francisco, Ortego-Centeno, Norberto, Sabio, José Mario, García-Morales, Marta, Universidad de Alicante. Departamento de Psicología de la Salud, Calidad de Vida, Bienestar Psicológico y Salud, and Psicología Aplicada a la Salud y Comportamiento Humano (PSYBHE)

Subjects
Systemic lupus erythematosus, Psychological stress, Risk factors, Psychopathology, immune system diseases, Psicología Básica
Abstract

Objective: To evaluate psychopathological status and stress level from a sample with SLE; compare mental functioning and stress levels between women with SLE and healthy women; determine whether disease duration, disease activity, cumulative organ damage and stress have an influence on psychopathological symptoms in SLE patients; and evaluate whether perception of stress is related to SLE severity. Methods: We conducted a cross-sectional study of 425 participants; 202 women with SLE, with an average age (SD) of 36.61 (10.15), and 223 healthy women, with age-matched controls. The assessment included the clinical characteristics (disease duration, SLE activity, cumulative organ damage, pharmacotherapy), the Symptom Checklist-90-Revised (SCL-90-R) and the Perceived Stress Scale. Descriptive, comparative, univariate and multivariate analysis were performed. Results: SLE patients showed psychopathological alterations in the somatisation, obsessive-compulsive and positive discomfort subscales of SCL-90-R. Women with SLE reported significantly higher scores on the psychopathological dimensions and perceived stress compared to healthy women, except for paranoid ideation. Disease duration, SLE activity, cumulative organ damage, and perceived stress were shown to be significant predictors of psychopathological manifestations, explaining a range, between 20 and 43%, of variance across SCL-90-R dimensions. Moreover, perceived stress was related to SLE activity, after controlling for psychopathological dimensions. Conclusion: The psychopathological manifestations in SLE appeared to be influenced by perceived stress, disease duration, disease activity and cumulative organ damage. In turn, perceived stress was associated with disease severity. This knowledge may contribute to a more comprehensive perspective of these manifestations in the SLE population in the clinical setting. This research was developed in the framework of the I+D Project “SEJ2007-61857” and the I+D Project ‘‘PSI2010- 15780’’, funded by the Spanish Ministry of Education and Science. In addition, this study was supported by the Andalusian Health Service (grant no. PI-0059/2007).

Published
2018

28. Colaboradores

Author

Manteca, Laura Abad, Meriel, Cristina Abraira, García, José M. Aguado, Díaz, Juan F. Alcalá, Fernández, Marta Aller, Castillo, Carlos Armiñanzas, Almajano, Francisco Arnaiz de las Revillas, Santa, Jaime Atance García de la, Aguinaga, Elena Aurrecoechea, Calzada, Carmela Baamonde, Conde, Cristina Baldeón, Toledo, María J. Benítez, Blanco, José A. Berciano, Alonso, Ricardo Blanco, Mediavilla, Francisco J. Burón, Olea, Rita Cabezas, Manuel, Elpidio Calvo, Caz, Marina Cobreros del, Pozo, Juan Crespo del, Facorro, Benedicto Crespo, Medina, Francisca Cuadrado, Alvarado, Manuel Delgado, Lista, Francisco J. Delgado, Curbelo, Luis Escobar, Álvarez, Concepción Fariñas, Álvarez, M. Carmen Fariñas, Giménez, Rafael A. Fernández de la Puebla, Fresnedo, Gema Fernández, Sampedro, Marta Fernández, Jiménez, Francisco J. Fuentes, Agromayor, Elena Gallardo, Hoyos, Marta García, Ibarbia, Carmen García, Klepzig, José Luis García, Rubio, Samuel García, Unzueta, Mayte García, Ezquerra, Pablo Garmilla, Delgado, Francisco Gómez, Garduño, Ángela Gómez, Macías, Jesús González, Mandly, Andrés González, Quintanilla, Vicente González, Rozas, Marta González, Sánchez, Francisco J. González, Vílchez, Francisco J. González, Hernández, José L. Hernández, Botella, Alba Ibáñez, Bermúdez, Rosario Iguarán, Ceberio, Jon Infante, Águila, Fernando Jaén, Gámiz, Laura Jáimez, Alonso, Juan F. Jiménez, López, M.ª Ángeles Jiménez, López, Yésica Jiménez, Álvaro, Rosa Landeras, Campo, Davinia Larrosa, Miranda, José López, Manzano-Gamero, M. Victoria, Lucas, Enrique Marco de, Sabio, José Mario, Hernández, Ángel L. Martín de Francisco, Escudero, Juan C. Martín, Antón, Silvia Martínez, Taboada, Víctor M. Martínez, Son, Jacqueline Mayoral van, Simón, David Morchón, Navarrete-Navarrete, Nuria, Calvo, Sara Neila, Martínez, José M. Olmos, Flores, Fernando Ortiz, Pardo-Cabello, Alfredo J., Blanco, José A. Parra, Gómez, Julio Pascual, González-Tablas, Teresa Pedraz, Castrillón, José L. Pérez, Martínez, Pablo Pérez, León, María Piedra, Alonso, Mónica Pineda, Esteban, José M. Polo, Ruiz, Nuria Puente, Sánchez, Ángela M. Puente, Carbajo, César Ramón, Moral, José A. Riancho, Zarrabeitia, Javier Riancho, Zarrabeitia, Leyre Riancho, Rodríguez, Eloy M. Rodríguez, Monroy, Irene Sangil, Gómez, Montserrat Santos, Zarrabeitia, Ana Santurtún, Zarrabeitia, Maite Santurtún, Silva, José T., Estívalez, Catalina Suso, Trippe, Jörn, Lamadrid, María C. Valero Díaz de, Prada, José A. Vázquez de, Vargas-Hitos, José A., Jacinto, Pedro Vázquez, Tejedor, Gemma Vega, and Cimiano, María T. Zarrabeitia

Published
2022
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31. Transancestral mapping and genetic load in systemic lupus erythematosus

Author

Langefeld, C. D., Ainsworth, H. C., Kelly, J. A., Comeau, M. E., Marion, M. C., Howard, T. D., Ramos, P. S., Croker, J. A., Morris, D. L., Sandling, J. K., Almlöf, J. C., Pons-Estel, Bernardo A., Pope, Janet, Raj, Prithvi, Ramsey-Goldman, Rosalind, Reveille, John D., Russell, Laurie P., Sabio, José Mario, Aguilar-Salinas, Carlos A., Scherbarth, Hugo R., Scorza, Raffaella, Seldin, Michael F., Sjowall, Christopher, Svenungsson, Elisabet, Thompson, Susan D., Toloza, Sergio M. A., Truedsson, Lennart, Tusie-Luna, Teresa, Vasconcelos, C., Vilá, Luis M., Wallace, Daniel J., Weisman, Michael H., Wither, Joan E., Bhangale, Tushar, Oksenberg, Jorge R., Rioux, John D., Gregersen, Peter K., Syvanen, Ann-Christine, Ronnblom, Lars, Criswell, Lindsey A., Jacob, Chaim O., Sivils, Kathy L., Tsao, Betty P., Schanberg, Laura E., Behrens, Timothy W., Silverman, Earl D., Alarcón-Riquelme, M. E., Kimberly, Robert P., Harley, John B., Wakeland, Edward K., Graham, Robert R., Gaffney, P. M., Vyse, Timothy J., Acevedo-Vásquez, E. M., Alarcón, G. S., Babini, A. M., Baca, V., Bengtsson, A. A., Berbotto, G. A., Bij, l. M., Brown, E. E., Brunner, H.I., Cardiel, Mario H., Catoggio, Luis, Cervera, Ricard, Cucho-Venegas, Jorge M., Dahlqvist, Solbritt Rantapaa, D'Alfonso, Sandra, Da Silva, Berta Martins, de la Rua Figueroa, Inigo, Doria, Andrea, Edberg, Jeffrey C., Endreffy, Emoke, Esquivel-Valerio, Jorge A., Fortin, Paul R., Freedman, Barry I., Frostegård, Johan, García, Mercedes A., García de la Torre, Ignacio, Gilkeson, G. S., Gladman, Dafna D., Gunnarsson, Iva, Guthridge, Joel M., Huggins, Jennifer L., James, Judith A., Kallenberg, Cees G. M., Kamen, D. L., Karp, David R., Kaufman, Kenneth M, Kottyan, Leah C., Kovacs, Laszlo, Laustrup, Helle, Lauwerys, Bernard R., Li, Quan-Zhen, Maradiaga-Cecena, Marco A., Martín, J., McCune, Joseph M., McWilliams, David R, Merrill, Joan T, Miranda, Pedro, Moctezuma, Jose F., Nath, Swapan K., Niewold, Timothy B., Orozco, Lorena, Ortego-Centeno, N., Petri, Michelle, Pineau, Christian A., National Institute for Health Research (UK), Arthritis Research UK, Alliance for Lupus Research, Junta de Andalucía, National Institute of Arthritis and Musculoskeletal and Skin Diseases (US), National Institutes of Health (US), RILITE Foundation, and Genentech Foundation

Subjects
skin and connective tissue diseases
Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (similar to 50% of these regions have multiple independent associations); these include 24 novel SLE regions (P < 5 x 10(-8)), refined association signals in established regions, extended associations to additional ancestries, and a disentangled complex HLA multigenic effect. The risk allele count (genetic load) exhibits an accelerating pattern of SLE risk, leading us to posit a cumulative hit hypothesis for autoimmune disease. Comparing results across the three ancestries identifies both ancestry-dependent and ancestry-independent contributions to SLE risk. Our results are consistent with the unique and complex histories of the populations sampled, and collectively help clarify the genetic architecture and ethnic disparities in SLE., We gratefully acknowledge the Alliance for Lupus Research for funding and support. The research was supported in part by awards from the Arthritis Research UK Special Strategic Award (ref. 19289) and from George Koukis (T.J.V.). In addition, the research was funded/supported by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London (T.J.V.). The work would not be possible without funding from the NIH grants AR049084 (RPK, EEB); the International Consortium on the Genetics of Systemic Lupus Erythematosus (SLEGEN) AI083194 (J.B.H.); CA141700, AR058621 Proyecto de Excelencia, Consejeria de Andalucia (M.E.A.R.); AR043814 and AR-065626 (B.P.T.); AR060366, MD007909, AI107176 (S.K.N.); AR-057172 (C.O.J.); RC2 AR058959, U19 A1082714, R01 AR063124, P30 GM110766, R01 AR056360 (P.M.G.); P60 AR053308 (L.A.C.), MUSC part is from UL1RR029882 (G.S.G., D.L.K.) and 5P60AR062755 (G.S.G., D.L.K., P.R.R.). Oklahoma Samples U19AI082714, U01AI101934, P30GM103510, U54GM104938 and P30AR053483 (J.A.J., J.M.G.); Northwestern P60 AR066464 and 1U54TR001018 (R.R.G.); This study was supported by the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health (NIH) under Award Numbers K01 AR067280 and P60 AR062755 (PSR); N01AR22265 (funded collection of APPLE samples) (LES) and the APPLE Investigators; R01AR43727, NIH AR 043727 and 069572 (M.P.); NIAMS/NIH P50-AR055503 (D.R.K.). We would like to also thank the RILITE foundation for financial support (C.D.L.). Additional funding for Immunochip genotyping was provided by Genentech.

Published
2017

33. Sleep quality and clinical and psychological manifestations in women with mild systemic lupus erythematosus activity compared to women with fibromyalgia: A preliminary study.

Author

Cervilla, Oscar, Miró, Elena, Martínez, María Pilar, Sánchez, Ana Isabel, Sabio, José Mario, and Prados, Germán

Subjects
SLEEP, FIBROMYALGIA, SYSTEMIC lupus erythematosus, ACTIGRAPHY, FATIGUE (Physiology), MENTAL depression, ANXIETY
Abstract

Objectives: This study analyzed sleep quality in fibromyalgia (FM) and systemic lupus erythematosus (SLE) and explored its relationship with other clinical and psychological manifestations.Methods: Twenty women with FM, 19 women with SLE and 22 healthy women participated in the study. Subjective sleep quality, fatigue, pain, depression and anxiety were evaluated with self-reports, and objective sleep measures were obtained with actigraphy. Comparisons were analyzed with Chi-square, Kruskal-Wallis's H and Mann-Whitney's U tests. Relationships between measurements were analyzed with Spearman's correlation coefficients.Results: Subjective sleep quality was altered in the FM and SLE groups compared to the control group (15.53 ± 3.27, 8.47 ± 3.20, 4.91 ± 2.79, p < .05, respectively). FM and SLE patients reported higher levels of pain (22.65 ± 9.87, 10.21 ± 9.93, 2.30 ± 3.096, p < .05), fatigue (4.67 ± 0.37, 3.59 ± 3.04, 2.33 ± 0.59, p < .05) and depressive symptoms (9.90 ± 3.78, 4.53 ± 3.04, 4.17 ± 3.95, p < .05) than controls, respectively. Worse subjective quality of sleep was associated with higher pain intensity and more depressive symptoms in FM and SLE. Actigraphy measures showed that FM patients spent more time in bed than subjects in the remaining groups.Conclusion: Sleep deterioration is related to more pain and depressive symptoms in FM and SLE. Addressing sleep disturbances may improve not only sleep quality but also depressive symptoms and pain. [ABSTRACT FROM AUTHOR]

Published
2020
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39. Association between perceived level of stress, clinical characteristics and psychopathological symptoms in women with systemic lupus erythematosus

Author

Universidad de Alicante. Departamento de Psicología de la Salud, Peralta-Ramírez, María Isabel, Pérez-Mármol, José Manuel, Castañeda-Cabestany, Margarita, Santos-Ruiz, Ana, Montero-López, Eva, Callejas-Rubio, José Luis, Navarrete-Navarrete, Nuria, Fernández-Sánchez, José Carlos, Jiménez-Alonso, Juan Francisco, Ortego-Centeno, Norberto, Sabio, José Mario, García-Morales, Marta, Universidad de Alicante. Departamento de Psicología de la Salud, Peralta-Ramírez, María Isabel, Pérez-Mármol, José Manuel, Castañeda-Cabestany, Margarita, Santos-Ruiz, Ana, Montero-López, Eva, Callejas-Rubio, José Luis, Navarrete-Navarrete, Nuria, Fernández-Sánchez, José Carlos, Jiménez-Alonso, Juan Francisco, Ortego-Centeno, Norberto, Sabio, José Mario, and García-Morales, Marta

Abstract

Objective: To evaluate psychopathological status and stress level from a sample with SLE; compare mental functioning and stress levels between women with SLE and healthy women; determine whether disease duration, disease activity, cumulative organ damage and stress have an influence on psychopathological symptoms in SLE patients; and evaluate whether perception of stress is related to SLE severity. Methods: We conducted a cross-sectional study of 425 participants; 202 women with SLE, with an average age (SD) of 36.61 (10.15), and 223 healthy women, with age-matched controls. The assessment included the clinical characteristics (disease duration, SLE activity, cumulative organ damage, pharmacotherapy), the Symptom Checklist-90-Revised (SCL-90-R) and the Perceived Stress Scale. Descriptive, comparative, univariate and multivariate analysis were performed. Results: SLE patients showed psychopathological alterations in the somatisation, obsessive-compulsive and positive discomfort subscales of SCL-90-R. Women with SLE reported significantly higher scores on the psychopathological dimensions and perceived stress compared to healthy women, except for paranoid ideation. Disease duration, SLE activity, cumulative organ damage, and perceived stress were shown to be significant predictors of psychopathological manifestations, explaining a range, between 20 and 43%, of variance across SCL-90-R dimensions. Moreover, perceived stress was related to SLE activity, after controlling for psychopathological dimensions. Conclusion: The psychopathological manifestations in SLE appeared to be influenced by perceived stress, disease duration, disease activity and cumulative organ damage. In turn, perceived stress was associated with disease severity. This knowledge may contribute to a more comprehensive perspective of these manifestations in the SLE population in the clinical setting.

Published
2018

40. Association of a rare variant of the TNFSF13B gene with susceptibility to Rheumatoid Arthritis and Systemic Lupus Erythematosus

Author

Junta de Andalucía, Redes Temáticas de Investigación Cooperativa en Salud (España), Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), Carreira, Patricia E. [0000-0001-8279-3806], González-Serna, David, Ortiz-Fernández, Lourdes, Vargas, Sofía, García, Antonio, Raya, Enrique, Fernández-Gutiérrez, Benjamín, López-Longo, Francisco Javier, Balsa, Alejandro, González-Álvaro, Isidoro, Narváez, Javier, Gómez-Vaquero, C., Sabio, José Mario, García-Portales, Rosa, González-Escribano, María Francisca, Tolosa-Vilella, Carles, Carreira, Patricia E., Kiemeney, Lambertus A., Coenen, Marieke J. H., Witte, Torsten, Schneider, Matthias, González-Gay, M. A., Martín, Javier, Junta de Andalucía, Redes Temáticas de Investigación Cooperativa en Salud (España), Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), Carreira, Patricia E. [0000-0001-8279-3806], González-Serna, David, Ortiz-Fernández, Lourdes, Vargas, Sofía, García, Antonio, Raya, Enrique, Fernández-Gutiérrez, Benjamín, López-Longo, Francisco Javier, Balsa, Alejandro, González-Álvaro, Isidoro, Narváez, Javier, Gómez-Vaquero, C., Sabio, José Mario, García-Portales, Rosa, González-Escribano, María Francisca, Tolosa-Vilella, Carles, Carreira, Patricia E., Kiemeney, Lambertus A., Coenen, Marieke J. H., Witte, Torsten, Schneider, Matthias, González-Gay, M. A., and Martín, Javier

Abstract

A rare variant (BAFF-var) of the tumor necrosis factor superfamily 13b (TNFSF13B) gene has been recently associated with multiple sclerosis (MS) and systemic lupus erythematosus (SLE). The aim of this study was to investigate the association between TNFSF13B BAFF-var and susceptibility to rheumatoid arthritis (RA) and replicate that association in SLE. 6,218 RA patients, 2,575 SLE patients and 4,403 healthy controls from three different countries were included in the study. TNFSF13B BAFF-var was genotyped using TaqMan allelic discrimination assay. PLINK software was used for statistical analyses. TNFSF13B BAFF-var was significantly associated with RA (p = 0.015, OR = 1.21, 95% CI = 1.03–1.41) in the Spanish cohort. A trend of association was observed in the Dutch (p = 0.115) and German (p = 0.228) RA cohorts. A meta-analysis of the three RA cohorts included in this study revealed a statistically significant association (p = 0.002, OR = 1.24, 95% CI = 1.10–1.38). In addition, TNFSF13B BAFF-var was significantly associated with SLE in the Spanish (p = 0.001, OR = 1.41, 95% CI = 1.14–1.74) and the German cohorts (p = 0.030, OR = 1.86, 95% CI = 1.05–3.28), with a statistically significant p-value obtained in the meta-analysis (p = 0.0002, OR = 1.46, 95% CI = 1.09–2.32). The results obtained confirm the known association of TNFSF13B BAFF-var with SLE and, for the first time, demonstrate that this variant contributes to susceptibility to RA.

Published
2018

41. A combined large-scale meta-analysis identifies COG6 as a novel shared risk locus for rheumatoid arthritis and systemic lupus erythematosus

Author

Márquez, Ana, Vidal-Bralo, Laura, Rodríguez-Rodríguez, Luis, González-Gay, Miguel, Balsa, Alejandro, González-Álvaro, Isidoro, Carreira, Patricia, Ortego-Centeno, Norberto, Ayala-Gutiérrez, María, García-Hernández, Francisco José, González-Escribano, M Francisca, Sabio, José Mario, Tolosa, Carles, Suárez, Ana, González, Antonio, Padyukov, Leonid, Worthington, Jane, Vyse, Timothy, Alarcón-Riquelme, Marta, Martin, Javier, Pers, J.O., Rheumatology Service, Hospital Clínico San Carlos, University Hospital La Paz, Madrid, University of Queensland [Brisbane], Karolinska Institutet [Stockholm], Faculty of Medicine, Section of Rheumatology, Imperial College London, Centre for Genomics and Oncological Reearch (GENYO), Instituto de Parasitología y Biomedicina López-Neyra (IPBLN-CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), CIC Brest, Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital de la Cavale Blanche, and Calvez, Ghislaine

Subjects
[SDV] Life Sciences [q-bio], [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience

Published
2016

46. Scalp necrosis

Author

Rosales-Castillo, Antonio, primary, García-Sánchez, Antonio, additional, and Sabio, José Mario, additional

Published
2017
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48. Transancestral mapping and genetic load in systemic lupus erythematosus

Author

National Institute for Health Research (UK), Arthritis Research UK, Alliance for Lupus Research, Junta de Andalucía, National Institute of Arthritis and Musculoskeletal and Skin Diseases (US), National Institutes of Health (US), RILITE Foundation, Genentech Foundation, Langefeld, C. D., Ainsworth, H. C., Kelly, J. A., Comeau, M. E., Marion, M. C., Howard, T. D., Ramos, P. S., Croker, J. A., Morris, D. L., Sandling, J. K., Almlöf, J. C., Pons-Estel, Bernardo A., Pope, Janet, Raj, Prithvi, Ramsey-Goldman, Rosalind, Reveille, John D., Russell, Laurie P., Sabio, José Mario, Aguilar-Salinas, Carlos A., Scherbarth, Hugo R., Scorza, Raffaella, Seldin, Michael F., Sjowall, Christopher, Svenungsson, Elisabet, Thompson, Susan D., Toloza, Sergio M. A., Truedsson, Lennart, Tusie-Luna, Teresa, Vasconcelos, C., Vilá, Luis M., Wallace, Daniel J., Weisman, Michael H., Wither, Joan E., Bhangale, Tushar, Oksenberg, Jorge R., Rioux, John D., Gregersen, Peter K., Syvanen, Ann-Christine, Ronnblom, Lars, Criswell, Lindsey A., Jacob, Chaim O., Sivils, Kathy L., Tsao, Betty P., Schanberg, Laura E., Behrens, Timothy W., Silverman, Earl D., Alarcón-Riquelme, M. E., Kimberly, Robert P., Harley, John B., Wakeland, Edward K., Graham, Robert R., Gaffney, P. M., Vyse, Timothy J., Acevedo-Vásquez, E. M., Alarcón, G. S., Babini, A. M., Baca, V., Bengtsson, A. A., Berbotto, G. A., Bij, l. M., Brown, E. E., Brunner, H.I., Cardiel, Mario H., Catoggio, Luis, Cervera, Ricard, Cucho-Venegas, Jorge M., Dahlqvist, Solbritt Rantapaa, D'Alfonso, Sandra, Da Silva, Berta Martins, de la Rua Figueroa, Inigo, Doria, Andrea, Edberg, Jeffrey C., Endreffy, Emoke, Esquivel-Valerio, Jorge A., Fortin, Paul R., Freedman, Barry I., Frostegård, Johan, García, Mercedes A., García de la Torre, Ignacio, Gilkeson, G. S., Gladman, Dafna D., Gunnarsson, Iva, Guthridge, Joel M., Huggins, Jennifer L., James, Judith A., Kallenberg, Cees G. M., Kamen, D. L., Karp, David R., Kaufman, Kenneth M, Kottyan, Leah C., Kovacs, Laszlo, Laustrup, Helle, Lauwerys, Bernard R., Li, Quan-Zhen, Maradiaga-Cecena, Marco A., Martín, J., McCune, Joseph M., McWilliams, David R, Merrill, Joan T, Miranda, Pedro, Moctezuma, Jose F., Nath, Swapan K., Niewold, Timothy B., Orozco, Lorena, Ortego-Centeno, N., Petri, Michelle, Pineau, Christian A., National Institute for Health Research (UK), Arthritis Research UK, Alliance for Lupus Research, Junta de Andalucía, National Institute of Arthritis and Musculoskeletal and Skin Diseases (US), National Institutes of Health (US), RILITE Foundation, Genentech Foundation, Langefeld, C. D., Ainsworth, H. C., Kelly, J. A., Comeau, M. E., Marion, M. C., Howard, T. D., Ramos, P. S., Croker, J. A., Morris, D. L., Sandling, J. K., Almlöf, J. C., Pons-Estel, Bernardo A., Pope, Janet, Raj, Prithvi, Ramsey-Goldman, Rosalind, Reveille, John D., Russell, Laurie P., Sabio, José Mario, Aguilar-Salinas, Carlos A., Scherbarth, Hugo R., Scorza, Raffaella, Seldin, Michael F., Sjowall, Christopher, Svenungsson, Elisabet, Thompson, Susan D., Toloza, Sergio M. A., Truedsson, Lennart, Tusie-Luna, Teresa, Vasconcelos, C., Vilá, Luis M., Wallace, Daniel J., Weisman, Michael H., Wither, Joan E., Bhangale, Tushar, Oksenberg, Jorge R., Rioux, John D., Gregersen, Peter K., Syvanen, Ann-Christine, Ronnblom, Lars, Criswell, Lindsey A., Jacob, Chaim O., Sivils, Kathy L., Tsao, Betty P., Schanberg, Laura E., Behrens, Timothy W., Silverman, Earl D., Alarcón-Riquelme, M. E., Kimberly, Robert P., Harley, John B., Wakeland, Edward K., Graham, Robert R., Gaffney, P. M., Vyse, Timothy J., Acevedo-Vásquez, E. M., Alarcón, G. S., Babini, A. M., Baca, V., Bengtsson, A. A., Berbotto, G. A., Bij, l. M., Brown, E. E., Brunner, H.I., Cardiel, Mario H., Catoggio, Luis, Cervera, Ricard, Cucho-Venegas, Jorge M., Dahlqvist, Solbritt Rantapaa, D'Alfonso, Sandra, Da Silva, Berta Martins, de la Rua Figueroa, Inigo, Doria, Andrea, Edberg, Jeffrey C., Endreffy, Emoke, Esquivel-Valerio, Jorge A., Fortin, Paul R., Freedman, Barry I., Frostegård, Johan, García, Mercedes A., García de la Torre, Ignacio, Gilkeson, G. S., Gladman, Dafna D., Gunnarsson, Iva, Guthridge, Joel M., Huggins, Jennifer L., James, Judith A., Kallenberg, Cees G. M., Kamen, D. L., Karp, David R., Kaufman, Kenneth M, Kottyan, Leah C., Kovacs, Laszlo, Laustrup, Helle, Lauwerys, Bernard R., Li, Quan-Zhen, Maradiaga-Cecena, Marco A., Martín, J., McCune, Joseph M., McWilliams, David R, Merrill, Joan T, Miranda, Pedro, Moctezuma, Jose F., Nath, Swapan K., Niewold, Timothy B., Orozco, Lorena, Ortego-Centeno, N., Petri, Michelle, and Pineau, Christian A.

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (similar to 50% of these regions have multiple independent associations); these include 24 novel SLE regions (P < 5 x 10(-8)), refined association signals in established regions, extended associations to additional ancestries, and a disentangled complex HLA multigenic effect. The risk allele count (genetic load) exhibits an accelerating pattern of SLE risk, leading us to posit a cumulative hit hypothesis for autoimmune disease. Comparing results across the three ancestries identifies both ancestry-dependent and ancestry-independent contributions to SLE risk. Our results are consistent with the unique and complex histories of the populations sampled, and collectively help clarify the genetic architecture and ethnic disparities in SLE.

Published
2017

49. Relationship between QT Interval Length and Arterial Stiffness in Systemic Lupus Erythematosus (SLE): A Cross-Sectional Case-Control Study

Author

Rivera-López, Ricardo, primary, Jiménez-Jáimez, Juan, additional, Sabio, José Mario, additional, Zamora-Pasadas, Mónica, additional, Vargas-Hitos, José Antonio, additional, Martínez-Bordonado, Josefina, additional, Navarrete-Navarrete, Nuria, additional, Fernández, Ricardo Rivera, additional, Sanchez-Cantalejo, E., additional, and Jiménez-Alonso, Juan, additional

Published
2016
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50. Association of Resting Heart Rate With Arterial Stiffness and Low-Grade Inflammation in Women With Systemic Lupus Erythematosus.

Author

Vargas-Hitos, José Antonio, Soriano-Maldonado, Alberto, Martinez-Bordonado, Josefa, Snchez-Berná, Isabel, Fernéndez-Bergés, Daniel, and Sabio, José Mario

Subjects
ARRHYTHMIA, SYSTEMIC lupus erythematosus treatment, BRADYCARDIA, BIOMARKERS, BLOOD sedimentation, BLOOD pressure, C-reactive protein, CARDIOVASCULAR diseases risk factors, CONFIDENCE intervals, FIBRINOGEN, HEART beat, HOMEOSTASIS, INFLAMMATION, INSULIN, RELAXATION for health, SMOKING, CROSS-sectional method, DISEASE risk factors
Abstract

Resting heart rate (RHR) is associated with arterial stiffness, inflammation, and cardiovascular (CV) and all-cause mortality in the general population and in patients at high CV risk. We assessed the association of RHR with arterial stiffness and low-grade inflammation (LGI) in a cross-sectional study that included 101 women with systemic lupus erythematosus (SLE) without a history of CV disease or arrhythmia or who were under treatment that may cause bradycardia. Pulse wave velocity (PWV; a measure of arterial stiffness), RHR, and markers of LGI (ie, C-reactive protein, fibrinogen, erythrocyte sedimentation rate, insulin, and homeostatic model assessment index) were measured. The patients with the highest RHR (quartile 4; mean RHR = 87.2 bpm) had a PWV 0.61 m/s (95% confidence interval [CI]: 0.08-1.14; P =.024) greater than patients with the lowest RHR (quartile 1; RHR = 63.0 bpm), independent of age, systolic blood pressure, disease activity, smoking, and being physically inactive. Similarly, patients with the highest RHR (quartile 4) showed a significantly less favorable clustered LGI index than patients in quartile 1 (b = .58; 95% CI: 0.212-0.948; P = .002). Higher RHR is associated with greater arterial stiffness and LGI in women with SLE. Further research to determine the prognostic value of RHR in this population is warranted. [ABSTRACT FROM AUTHOR]

Published
2018
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