Search

Your search keyword '"Sabino, Ester C."' showing total 796 results
Start Over Author "Sabino, Ester C."
796 results on '"Sabino, Ester C."'

1. Molecular Epidemiology of Mayaro Virus among Febrile Patients, Roraima State, Brazil, 2018-2021

Author

Forato, Julia, Meira, Cassio A., Claro, Ingra M., Amorim, Mariene R., de Souza, Gabriela F., Muraro, Stefanie P., Toledo- Teixeira, Daniel A., Dias, Miguel F., Meneses, Catia A.R., Angerami, Rodrigo N., Lalwani, Pritesh, Weaver, Scott C., Sabino, Ester C., Faria, Nuno R., de Souza, William M., Granja, Fabiana, and Proenca-Modena, Jose Luiz

Subjects
Roraima, Brazil -- Health aspects, Fever -- Statistics -- Causes of, RNA virus infections -- Statistics -- Causes of -- Complications and side effects, Hyperthermia -- Statistics -- Causes of, Health
Abstract

Mayaro virus (MAYV) is an endemic and neglected mosquitoborne alphavirus that causes acute and chronic debilitating arthritogenic disease in Latin America and the Caribbean (1). MAYV infection can cause fever, [...]

Published
2024
Full Text
View/download PDF

2. Human movement and environmental barriers shape the emergence of dengue

Author

Harish, Vinyas, Colón-González, Felipe J., Moreira, Filipe R. R., Gibb, Rory, Kraemer, Moritz U. G., Davis, Megan, Reiner, Jr., Robert C., Pigott, David M., Perkins, T. Alex, Weiss, Daniel J., Bogoch, Isaac I., Vazquez-Prokopec, Gonzalo, Saide, Pablo Manrique, Barbosa, Gerson L., Sabino, Ester C., Khan, Kamran, Faria, Nuno R., Hay, Simon I., Correa-Morales, Fabián, Chiaravalloti-Neto, Francisco, and Brady, Oliver J.

Published
2024
Full Text
View/download PDF

4. Multiplex qPCR Discriminates Variants of Concern to Enhance Global Surveillance of SARS-CoV-2

Author

Vogels, Chantal B. F., primary, Breban, Mallery I., additional, Ott, Isabel M., additional, Alpert, Tara, additional, Petrone, Mary E., additional, Watkins, Anne E., additional, Kalinich, Chaney C., additional, Earnest, Rebecca, additional, Rothman, Jessica E., additional, de Jesus, Jaqueline Goes, additional, Claro, Ingra Morales, additional, Ferreira, Giulia Magalhães, additional, Crispim, Myuki A. E., additional, Singh, Lavanya, additional, Tegally, Houriiyah, additional, Anyaneji, Ugochukwu J., additional, Hodcroft, Emma B., additional, Mason, Christopher E., additional, Khullar, Gaurav, additional, Metti, Jessica, additional, Dudley, Joel T., additional, MacKay, Matthew J., additional, Nash, Megan, additional, Wang, Jianhui, additional, Liu, Chen, additional, Hui, Pei, additional, Murphy, Steven, additional, Neal, Caleb, additional, Laszlo, Eva, additional, Landry, Marie L., additional, Muyombwe, Anthony, additional, Downing, Randy, additional, Razeq, Jafar, additional, de Oliveira, Tulio, additional, Faria, Nuno R., additional, Sabino, Ester C., additional, Neher, Richard A., additional, Fauver, Joseph R., additional, and Grubaugh, Nathan D., additional

Published
2023
Full Text
View/download PDF

5. Pathophysiology of chikungunya virus infection associated with fatal outcomes

Author

de Souza, William M., Fumagalli, Marcilio J., de Lima, Shirlene T.S., Parise, Pierina L., Carvalho, Deyse C.M., Hernandez, Cristian, de Jesus, Ronaldo, Delafiori, Jeany, Candido, Darlan S., Carregari, Victor C., Muraro, Stefanie P., Souza, Gabriela F., Simões Mello, Leda M., Claro, Ingra M., Díaz, Yamilka, Kato, Rodrigo B., Trentin, Lucas N., Costa, Clauber H.S., Maximo, Ana Carolina B.M., Cavalcante, Karene F., Fiuza, Tayna S., Viana, Vânia A.F., Melo, Maria Elisabeth L., Ferraz, Clarissa P.M., Silva, Débora B., Duarte, Larissa M.F., Barbosa, Priscilla P., Amorim, Mariene R., Judice, Carla C., Toledo-Teixeira, Daniel A., Ramundo, Mariana S., Aguilar, Patricia V., Araújo, Emerson L.L., Costa, Fabio T.M., Cerqueira-Silva, Thiago, Khouri, Ricardo, Boaventura, Viviane S., Figueiredo, Luiz Tadeu M., Fang, Rong, Moreno, Brechla, López-Vergès, Sandra, Mello, Liana Perdigão, Skaf, Munir S., Catharino, Rodrigo R., Granja, Fabiana, Martins-de-Souza, Daniel, Plante, Jessica A., Plante, Kenneth S., Sabino, Ester C., Diamond, Michael S., Eugenin, Eliseo, Proença-Módena, José Luiz, Faria, Nuno R., and Weaver, Scott C.

Published
2024
Full Text
View/download PDF

6. Chikungunya: a decade of burden in the Americas

Author

de Souza, William M., Ribeiro, Guilherme S., de Lima, Shirlene T.S., de Jesus, Ronaldo, Moreira, Filipe R.R., Whittaker, Charles, Sallum, Maria Anice M., Carrington, Christine V.F., Sabino, Ester C., Kitron, Uriel, Faria, Nuno R., and Weaver, Scott C.

Published
2024
Full Text
View/download PDF

7. Global disparities in SARS-CoV-2 genomic surveillance

Author

Brito, Anderson F, Semenova, Elizaveta, Dudas, Gytis, Hassler, Gabriel W, Kalinich, Chaney C, Kraemer, Moritz UG, Ho, Joses, Tegally, Houriiyah, Githinji, George, Agoti, Charles N, Matkin, Lucy E, Whittaker, Charles, Howden, Benjamin P, Sintchenko, Vitali, Zuckerman, Neta S, Mor, Orna, Blankenship, Heather M, de Oliveira, Tulio, Lin, Raymond TP, Siqueira, Marilda Mendonça, Resende, Paola Cristina, Vasconcelos, Ana Tereza R, Spilki, Fernando R, Aguiar, Renato Santana, Alexiev, Ivailo, Ivanov, Ivan N, Philipova, Ivva, Carrington, Christine VF, Sahadeo, Nikita SD, Branda, Ben, Gurry, Céline, Maurer-Stroh, Sebastian, Naidoo, Dhamari, von Eije, Karin J, Perkins, Mark D, van Kerkhove, Maria, Hill, Sarah C, Sabino, Ester C, Pybus, Oliver G, Dye, Christopher, Bhatt, Samir, Flaxman, Seth, Suchard, Marc A, Grubaugh, Nathan D, Baele, Guy, and Faria, Nuno R

Subjects
Biological Sciences, Bioinformatics and Computational Biology, Health Sciences, Prevention, Human Genome, Biodefense, Vaccine Related, Immunization, Emerging Infectious Diseases, Genetics, Infection, Good Health and Well Being, Humans, SARS-CoV-2, Genome, Viral, COVID-19, Pandemics, Genomics, Bulgarian SARS-CoV-2 sequencing group, Communicable Diseases Genomics Network, COVID-19 Impact Project, Danish Covid-19 Genome Consortium, Fiocruz COVID-19 Genomic Surveillance Network, GISAID core curation team, Network for Genomic Surveillance in South Africa, Swiss SARS-CoV-2 Sequencing Consortium
Abstract

Genomic sequencing is essential to track the evolution and spread of SARS-CoV-2, optimize molecular tests, treatments, vaccines, and guide public health responses. To investigate the global SARS-CoV-2 genomic surveillance, we used sequences shared via GISAID to estimate the impact of sequencing intensity and turnaround times on variant detection in 189 countries. In the first two years of the pandemic, 78% of high-income countries sequenced >0.5% of their COVID-19 cases, while 42% of low- and middle-income countries reached that mark. Around 25% of the genomes from high income countries were submitted within 21 days, a pattern observed in 5% of the genomes from low- and middle-income countries. We found that sequencing around 0.5% of the cases, with a turnaround time

Published
2022

8. Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed

Author

Taub, Margaret A, Conomos, Matthew P, Keener, Rebecca, Iyer, Kruthika R, Weinstock, Joshua S, Yanek, Lisa R, Lane, John, Miller-Fleming, Tyne W, Brody, Jennifer A, Raffield, Laura M, McHugh, Caitlin P, Jain, Deepti, Gogarten, Stephanie M, Laurie, Cecelia A, Keramati, Ali, Arvanitis, Marios, Smith, Albert V, Heavner, Benjamin, Barwick, Lucas, Becker, Lewis C, Bis, Joshua C, Blangero, John, Bleecker, Eugene R, Burchard, Esteban G, Celedón, Juan C, Chang, Yen Pei C, Custer, Brian, Darbar, Dawood, de las Fuentes, Lisa, DeMeo, Dawn L, Freedman, Barry I, Garrett, Melanie E, Gladwin, Mark T, Heckbert, Susan R, Hidalgo, Bertha A, Irvin, Marguerite R, Islam, Talat, Johnson, W Craig, Kaab, Stefan, Launer, Lenore, Lee, Jiwon, Liu, Simin, Moscati, Arden, North, Kari E, Peyser, Patricia A, Rafaels, Nicholas, Seidman, Christine, Weeks, Daniel E, Wen, Fayun, Wheeler, Marsha M, Williams, L Keoki, Yang, Ivana V, Zhao, Wei, Aslibekyan, Stella, Auer, Paul L, Bowden, Donald W, Cade, Brian E, Chen, Zhanghua, Cho, Michael H, Cupples, L Adrienne, Curran, Joanne E, Daya, Michelle, Deka, Ranjan, Eng, Celeste, Fingerlin, Tasha E, Guo, Xiuqing, Hou, Lifang, Hwang, Shih-Jen, Johnsen, Jill M, Kenny, Eimear E, Levin, Albert M, Liu, Chunyu, Minster, Ryan L, Naseri, Take, Nouraie, Mehdi, Reupena, Muagututi A Sefuiva, Sabino, Ester C, Smith, Jennifer A, Smith, Nicholas L, Lasky-Su, Jessica, Taylor, James G, Telen, Marilyn J, Tiwari, Hemant K, Tracy, Russell P, White, Marquitta J, Zhang, Yingze, Wiggins, Kerri L, Weiss, Scott T, Vasan, Ramachandran S, Taylor, Kent D, Sinner, Moritz F, Silverman, Edwin K, Shoemaker, M Benjamin, Sheu, Wayne H-H, Sciurba, Frank, Schwartz, David A, Rotter, Jerome I, Roden, Daniel, Redline, Susan, and Raby, Benjamin A

Subjects
Epidemiology, Biological Sciences, Health Sciences, Genetics, Human Genome, Biotechnology, Aetiology, 2.1 Biological and endogenous factors, Generic health relevance, Good Health and Well Being, NHLBI CARE Network, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Hematology and Hemostasis Working Group, TOPMed Structural Variation Working Group
Abstract

Genetic studies on telomere length are important for understanding age-related diseases. Prior GWAS for leukocyte TL have been limited to European and Asian populations. Here, we report the first sequencing-based association study for TL across ancestrally-diverse individuals (European, African, Asian and Hispanic/Latino) from the NHLBI Trans-Omics for Precision Medicine (TOPMed) program. We used whole genome sequencing (WGS) of whole blood for variant genotype calling and the bioinformatic estimation of telomere length in n=109,122 individuals. We identified 59 sentinel variants (p-value

Published
2022

9. Prevalence and Risk Factors for Human T-Cell Lymphotropic Virus (HTLV) in Blood Donors in Brazil—A 10-Year Study (2007–2016)

Author

Miranda, Carolina, Utsch-Gonçalves, Denise, Piassi, Fabiana Chagas Camargos, Loureiro, Paula, Gomes, Isabel, Ribeiro, Maísa Aparecida, de Almeida-Neto, César, Blatyta, Paula, Amorim, Luiz, Mateos, Sheila Oliveira Garcia, Murphy, Edward L, Custer, Brian, Carneiro-Proietti, Anna Barbara F, and Sabino, Ester C

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Infectious Diseases, Infection, Good Health and Well Being, HTLV-1, 2, blood donors, prevalence, risk factor, sexually transmitted infections, HTLV-1/2, Biomedical and clinical sciences, Health sciences
Abstract

It is unknown whether HTLV-1/2 prevalence has been stable or changing with time in Brazil. We present a 10-year (2007-2016) analysis of HTLV-1/2 infection in first-time blood donors from four blood banks in Brazil. The Brazilian blood centers participating in this multicenter Recipient Epidemiology and Donor Evaluation Study (REDS) are located in Recife in the Northeast and in São Paulo, Rio de Janeiro and Belo Horizonte located in the Southeast of the country. A previous REDS study using the same database from 2007 to 2009 showed that the prevalence per 100,000 donors was 222 in Recife, 83 in Belo Horizonte and 101 in São Paulo. From 2007 to 2016, HTLV-1/2 prevalence was calculated by year, blood center and birth cohort. Covariates included age, gender, schooling, self-reported skin color and type of donation. From 1,092,174 first-blood donations, in the general analysis, HTLV-1/2 infection predominated in females, donors over 50 years of age, black skin color and less educated. The average prevalence was 228 per 100,000 donors in Recife, 222 in Rio de Janeiro, 104 in Belo Horizonte and 103 in São Paulo. In the 10-year analysis, HTLV-1/2 prevalence was stable, but a trend was observed toward an increase in HTLV-1/2 infection among younger people (p < 0.001), males (p = 0.049), those with white skin color (p < 0.001), and higher education (p = 0.014). Therefore, this 10-year surveillance of the infection showed stable HTLV-1/2 prevalence overall but a trend toward increased prevalence among the younger and more educated donors despite Brazilian policies to control sexually transmitted infections being in place for more than 10 years.

Published
2022

10. Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil

Author

Faria, Nuno R, Mellan, Thomas A, Whittaker, Charles, Claro, Ingra M, Candido, Darlan da S, Mishra, Swapnil, Crispim, Myuki AE, Sales, Flavia CS, Hawryluk, Iwona, McCrone, John T, Hulswit, Ruben JG, Franco, Lucas AM, Ramundo, Mariana S, de Jesus, Jaqueline G, Andrade, Pamela S, Coletti, Thais M, Ferreira, Giulia M, Silva, Camila AM, Manuli, Erika R, Pereira, Rafael HM, Peixoto, Pedro S, Kraemer, Moritz UG, Gaburo, Nelson, Camilo, Cecilia da C, Hoeltgebaum, Henrique, Souza, William M, Rocha, Esmenia C, de Souza, Leandro M, de Pinho, Mariana C, Araujo, Leonardo JT, Malta, Frederico SV, de Lima, Aline B, Silva, Joice do P, Zauli, Danielle AG, Ferreira, Alessandro C de S, Schnekenberg, Ricardo P, Laydon, Daniel J, Walker, Patrick GT, Schlüter, Hannah M, Dos Santos, Ana LP, Vidal, Maria S, Del Caro, Valentina S, Filho, Rosinaldo MF, Dos Santos, Helem M, Aguiar, Renato S, Proença-Modena, José L, Nelson, Bruce, Hay, James A, Monod, Mélodie, Miscouridou, Xenia, Coupland, Helen, Sonabend, Raphael, Vollmer, Michaela, Gandy, Axel, Prete, Carlos A, Nascimento, Vitor H, Suchard, Marc A, Bowden, Thomas A, Pond, Sergei LK, Wu, Chieh-Hsi, Ratmann, Oliver, Ferguson, Neil M, Dye, Christopher, Loman, Nick J, Lemey, Philippe, Rambaut, Andrew, Fraiji, Nelson A, Carvalho, Maria do PSS, Pybus, Oliver G, Flaxman, Seth, Bhatt, Samir, and Sabino, Ester C

Subjects
Human Genome, Immunization, Pneumonia & Influenza, Lung, Prevention, Genetics, Vaccine Related, Biotechnology, Pneumonia, Emerging Infectious Diseases, Biodefense, Infectious Diseases, Infection, Good Health and Well Being, Angiotensin-Converting Enzyme 2, Brazil, COVID-19, Communicable Diseases, Emerging, Epidemiological Monitoring, Genome, Viral, Genomics, Humans, Models, Theoretical, Molecular Epidemiology, Mutation, Protein Binding, SARS-CoV-2, Spike Glycoprotein, Coronavirus, Viral Load, General Science & Technology
Abstract

Cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Manaus, Brazil, resurged in late 2020 despite previously high levels of infection. Genome sequencing of viruses sampled in Manaus between November 2020 and January 2021 revealed the emergence and circulation of a novel SARS-CoV-2 variant of concern. Lineage P.1 acquired 17 mutations, including a trio in the spike protein (K417T, E484K, and N501Y) associated with increased binding to the human ACE2 (angiotensin-converting enzyme 2) receptor. Molecular clock analysis shows that P.1 emergence occurred around mid-November 2020 and was preceded by a period of faster molecular evolution. Using a two-category dynamical model that integrates genomic and mortality data, we estimate that P.1 may be 1.7- to 2.4-fold more transmissible and that previous (non-P.1) infection provides 54 to 79% of the protection against infection with P.1 that it provides against non-P.1 lineages. Enhanced global genomic surveillance of variants of concern, which may exhibit increased transmissibility and/or immune evasion, is critical to accelerate pandemic responsiveness.

Published
2021

11. Spatial and temporal fluctuations in COVID-19 fatality rates in Brazilian hospitals

Author

Brizzi, Andrea, Whittaker, Charles, Servo, Luciana M. S., Hawryluk, Iwona, Prete, Jr, Carlos A., de Souza, William M., Aguiar, Renato S., Araujo, Leonardo J. T., Bastos, Leonardo S., Blenkinsop, Alexandra, Buss, Lewis F., Candido, Darlan, Castro, Marcia C., Costa, Silvia F., Croda, Julio, de Souza Santos, Andreza Aruska, Dye, Christopher, Flaxman, Seth, Fonseca, Paula L. C., Geddes, Victor E. V., Gutierrez, Bernardo, Lemey, Philippe, Levin, Anna S., Mellan, Thomas, Bonfim, Diego M., Miscouridou, Xenia, Mishra, Swapnil, Monod, Mélodie, Moreira, Filipe R. R., Nelson, Bruce, Pereira, Rafael H. M., Ranzani, Otavio, Schnekenberg, Ricardo P., Semenova, Elizaveta, Sonabend, Raphael, Souza, Renan P., Xi, Xiaoyue, Sabino, Ester C., Faria, Nuno R., Bhatt, Samir, and Ratmann, Oliver

Published
2022
Full Text
View/download PDF

12. Test seeking: are healthcare professionals referring people to blood centers for infections marker testing?

Author

Moreno, Elizabeth C, Bruhn, Roberta, Sabino, Ester C, Bolina-Santos, Eduarda, Miranda, Carolina, Carneiro-Proietti, Anna Barbara, Lopes, Maria Esther, de Almeida-Neto, Cesar, Loureiro, Paula, Capuani, Ligia, Takecian, Pedro L, Custer, Brian, and Gonçalez, Thelma T

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, HIV/AIDS, Health Services, Behavioral and Social Science, Clinical Research, Infectious Diseases, 8.1 Organisation and delivery of services, Health and social care services research, Infection, Good Health and Well Being, Blood donation, Healthcare professionals, Test-seeking, Cardiovascular medicine and haematology
Abstract

BackgroundTest-seeking is associated with HIV in Brazilian blood donors. This study sought to investigate the frequency with which three different donor groups: deferred donors, accepted donors who tested HIV positive [HIV (+)], and accepted donors who tested infectious disease markers negative [IDM (-)], came to the blood bank at the suggestion of a health care professional.Study design and methodsDonors deferred for reporting high-risk behaviors and participants in an HIV risk factor case-control study completed a confidential audio computer-assisted self-interview (ACASI) that included two questions related to health care professionals and test-seeking.ResultsOf 4013 enrolled deferred donors, 468 (11.8%) reported a health care professional suggested donation as a way to be tested for infection. Of 341 HIV (+) and 791 IDM (-) participants, 43 (12.6%) and 11 (1.4%), respectively, reported a health care professional suggested donation as a way to be tested for infection. Physicians were the most frequently reported source of referral: [(61.5% of deferred, 69.1% of HIV (+), and 9.1% of IDM (-) donors)].ConclusionHIV (+) donors and deferred donors were 10 times more likely to report test-seeking behavior by suggestion of health care professional than IDM (-) donors. If true, efforts should be made to educate health care professionals and blood donors on how to safeguard the blood supply, emphasizing that HIV testing should be done at volunteer testing centers rather than at the blood centers.

Published
2019

13. Epidemiology of COVID-19 after Emergence of SARS-CoV-2 Gamma Variant, Brazilian Amazon, 2020-2021

Author

Nicolete, Vanessa C., Rodrigues, Priscila T., Fernandes, Anderson R.J., Corder, Rodrigo M., Tonini, Juliana, Buss, Lewis F., Sales, Flavia C., Faria, Nuno R., Sabino, Ester C., Castro, Marcia C., and Ferreira, Marcelo U.

Subjects
Amazonas, Brazil -- Health aspects, Company distribution practices, Health
Abstract

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Gamma (P.1) variant emerged in November 2020 and drove the second wave of coronavirus disease (COVID-19) in Brazil. Emergence of this [...]

Published
2022
Full Text
View/download PDF

15. Correlating drug prescriptions with prognosis in severe COVID-19: first step towards resource management

Author

Levin, Anna S., Freire, Maristela P., Oliveira, Maura Salaroli de, Nastri, Ana Catharina S., Harima, Leila S., Perdigão-Neto, Lauro Vieira, Magri, Marcello M., Fialkovitz, Gabriel, Figueiredo, Pedro H. M. F., Siciliano, Rinaldo Focaccia, Sabino, Ester C., Carlotti, Danilo P. N., Rodrigues, Davi Silva, Nunes, Fátima L. S., and Ferreira, João Eduardo

Published
2022
Full Text
View/download PDF

18. Immunogenicity and safety of two doses of the CoronaVac SARS-CoV-2 vaccine in SARS-CoV-2 seropositive and seronegative patients with autoimmune rheumatic diseases in Brazil: a subgroup analysis of a phase 4 prospective study

Author

Aikawa, Nadia E, Kupa, Leonard V K, Pasoto, Sandra G, Medeiros-Ribeiro, Ana C, Yuki, Emily F N, Saad, Carla G S, Pedrosa, Tatiana, Fuller, Ricardo, Shinjo, Samuel K, Sampaio-Barros, Percival D, Andrade, Danieli C O, Pereira, Rosa M R, Seguro, Luciana P C, Valim, Juliana M L, Waridel, Filipe, Sartori, Ana Marli C, Duarte, Alberto J S, Antonangelo, Leila, Sabino, Ester C, Menezes, Paulo Rossi, Kallas, Esper G, Silva, Clovis A, and Bonfa, Eloisa

Published
2022
Full Text
View/download PDF

20. Phylogenetics, Epidemiology and Temporal Patterns of Dengue Virus in Araraquara, São Paulo State

Author

de Souza, Caio Santos, primary, Caleiro, Giovana Santos, additional, Claro, Ingra Morales, additional, de Jesus, Jaqueline Goes, additional, Coletti, Thaís Moura, additional, da Silva, Camila Alves Maia, additional, Costa, Ângela Aparecida, additional, Inenami, Marta, additional, Ribeiro, Andreia C., additional, Felix, Alvina Clara, additional, de Paula, Anderson Vicente, additional, Figueiredo, Walter M., additional, de Albuquerque Luna, Expedito José, additional, Sabino, Ester C., additional, and Romano, Camila M., additional

Published
2024
Full Text
View/download PDF

22. Neutralisation of SARS-CoV-2 lineage P.1 by antibodies elicited through natural SARS-CoV-2 infection or vaccination with an inactivated SARS-CoV-2 vaccine: an immunological study

Author

Souza, William M, Amorim, Mariene R, Sesti-Costa, Renata, Coimbra, Lais D, Brunetti, Natalia S, Toledo-Teixeira, Daniel A, de Souza, Gabriela F, Muraro, Stefanie P, Parise, Pierina L, Barbosa, Priscilla P, Bispo-dos-Santos, Karina, Mofatto, Luciana S, Simeoni, Camila L, Claro, Ingra M, Duarte, Adriana S S, Coletti, Thais M, Zangirolami, Audrey B, Costa-Lima, Carolina, Gomes, Arilson B S P, Buscaratti, Lucas I, Sales, Flavia C, Costa, Vitor A, Franco, Lucas A M, Candido, Darlan S, Pybus, Oliver G, de Jesus, Jaqueline G, Silva, Camila A M, Ramundo, Mariana S, Ferreira, Giulia M, Pinho, Mariana C, Souza, Leandro M, Rocha, Esmenia C, Andrade, Pamela S, Crispim, Myuki A E, Maktura, Grazielle C, Manuli, Erika R, Santos, Magnun N N, Camilo, Cecilia C, Angerami, Rodrigo N, Moretti, Maria L, Spilki, Fernando R, Arns, Clarice W, Addas-Carvalho, Marcelo, Benites, Bruno D, Vinolo, Marco A R, Mori, Marcelo A S, Gaburo, Nelson, Dye, Christopher, Marques-Souza, Henrique, Marques, Rafael E, Farias, Alessandro S, Diamond, Michael S, Faria, Nuno R, Sabino, Ester C, Granja, Fabiana, and Proença-Módena, Jose Luiz

Published
2021
Full Text
View/download PDF

23. Immunogenicity and safety of the CoronaVac inactivated vaccine in patients with autoimmune rheumatic diseases: a phase 4 trial

Author

Medeiros-Ribeiro, Ana C., Aikawa, Nadia E., Saad, Carla G. S., Yuki, Emily F. N., Pedrosa, Tatiana, Fusco, Solange R. G., Rojo, Priscila T., Pereira, Rosa M. R., Shinjo, Samuel K., Andrade, Danieli C. O., Sampaio-Barros, Percival D., Ribeiro, Carolina T., Deveza, Giordano B. H., Martins, Victor A. O., Silva, Clovis A., Lopes, Marta H., Duarte, Alberto J. S., Antonangelo, Leila, Sabino, Ester C., Kallas, Esper G., Pasoto, Sandra G., and Bonfa, Eloisa

Published
2021
Full Text
View/download PDF

24. Respiratory Viral Shedding in Healthcare Workers Reinfected with SARS-CoV-2, Brazil, 2020

Author

Amorim, Mariene R., Souza, William M., Barros, Antonio C.G., Jr., Toledo-Teixeira, Daniel A., Bispo-dos-Santos, Karina, Simeoni, Camila L., Parise, Pierina L., Vieira, Aline, Forato, Julia, Claro, Ingra M., Mofatto, Luciana S., Barbosa, Priscila P., Brunetti, Natalia S., Franca, Emerson S.S., Pedroso, Gisele A., Carvalho, Barbara F.N., Zaccariotto, Tania R., Krywacz, Kamila C.S., Vieira, Andre S., Mori, Marcelo A., Farias, Alessandro S., Pavan, Maria H.P., Bachur, Luis Felipe, Cardoso, Luis G.O., Spilki, Fernando R., Sabino, Ester C., Faria, Nuno R., Santos, Magnun N.N., Angerami, Rodrigo, Leme, Patricia A.F., Schreiber, Angelica, Moretti, Maria L., Granja, Fabiana, and Proenca-Modena, Jose Luiz

Subjects
Diseases -- Relapse, Respiratory tract infections -- Diagnosis -- Development and progression, Medical personnel -- Case studies -- Health aspects, Health
Abstract

Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in Wuhan, China, in late 2019. As of April 8, 2021, COVID-19 has affected >132 [...]

Published
2021
Full Text
View/download PDF

26. Tracking arboviruses, their transmission vectors and potential hosts by nanopore sequencing of mosquitoes

Author

Mirza, Jeremy D., primary, de Oliveira Guimarães, Lilian, additional, Wilkinson, Sam, additional, Rocha, Esmenia C., additional, Bertanhe, Mayara, additional, Helfstein, Vanessa Christe, additional, de-Deus, Juliana Telles, additional, Claro, Ingra M., additional, Cumley, Nicola, additional, Quick, Joshua, additional, Faria, Nuno R., additional, Sabino, Ester C., additional, Kirchgatter, Karin, additional, and Loman, Nicholas J., additional

Published
2024
Full Text
View/download PDF

28. Parasite DNA and Markers of Decreased Immune Activation Associate Prospectively with Cardiac Functional Decline over 10 Years among Trypanosoma cruzi Seropositive Individuals in Brazil

Author

Sunderraj, Ashwin, primary, Cunha, Luisa Marin, additional, Avila, Matheus, additional, Alexandria, Shaina, additional, Ferreira, Ariela Mota, additional, de Oliveira-da Silva, Léa Campos, additional, Ribeiro, Antonio L. P., additional, Nunes, Maria do Carmo Pereira, additional, Sabino, Ester C., additional, Landay, Alan, additional, Kalil, Jorge, additional, Chevillard, Christophe, additional, Cunha-Neto, Edecio, additional, and Feinstein, Matthew J., additional

Published
2023
Full Text
View/download PDF

29. Real-time RT-PCR for Venezuelan equine encephalitis complex, Madariaga, and Eastern equine encephalitis viruses: application in human and mosquito public health surveillance in Panama

Author

Carrera, Jean-Paul, primary, Araúz, Dimelza, additional, Rojas, Alejandra, additional, Cardozo, Fátima, additional, Stittleburg, Victoria, additional, Morales Claro, Ingra, additional, Galue, Josefrancisco, additional, Lezcano-Coba, Carlos, additional, Romero Rebello Moreira, Filipe, additional, -Rivera, Luis Felipe, additional, Chen-Germán, Maria, additional, Moreno, Brechla, additional, Capitan-Barrios, Zeuz, additional, López-Vergès, Sandra, additional, Pascale, Juan Miguel, additional, Sabino, Ester C., additional, Valderrama, Anayansi, additional, Hanley, Kathryn A., additional, Donnelly, Christl A., additional, Vasilakis, Nikos, additional, Faria, Nuno R., additional, and Waggoner, Jesse J., additional

Published
2023
Full Text
View/download PDF

30. Title Impact of Exogenous Lactobacillus plantarum on the Gut Microbiome of Hematopoietic Stem Cell Transplantation Patients Colonized by Multi-Drug Resistant Bacteria

Author

Moraes, Bruna D.G.C., primary, Martins, Roberta CR, additional, Fonseca, Joyce Vanessa da Silva, additional, Franco, Lucas AM, additional, Pereira, Gaspar CO, additional, Bartelli, Thaisi F, additional, Cortes, Marina F, additional, Santos, Carolina F, additional, Musqueira, Priscila T, additional, Otuyama, Leonardo J, additional, Pylro, Victor S., additional, Mariano, Livia, additional, Rocha, Vanderson, additional, Witkin, Steven S, additional, Sabino, Ester C, additional, Guimaraes, Thais, additional, and Costa, Silvia F, additional

Published
2023
Full Text
View/download PDF

33. Epidemiological and clinical characteristics of the COVID-19 epidemic in Brazil

Author

de Souza, William Marciel, Buss, Lewis Fletcher, Candido, Darlan da Silva, Carrera, Jean-Paul, Li, Sabrina, Zarebski, Alexander E., Pereira, Rafael Henrique Moraes, Prete, Jr, Carlos A., de Souza-Santos, Andreza Aruska, Parag, Kris V., Belotti, Maria Carolina T. D., Vincenti-Gonzalez, Maria F., Messina, Janey, da Silva Sales, Flavia Cristina, Andrade, Pamela dos Santos, Nascimento, Vítor Heloiz, Ghilardi, Fabio, Abade, Leandro, Gutierrez, Bernardo, Kraemer, Moritz U. G., Braga, Carlos K. V., Aguiar, Renato Santana, Alexander, Neal, Mayaud, Philippe, Brady, Oliver J., Marcilio, Izabel, Gouveia, Nelson, Li, Guangdi, Tami, Adriana, de Oliveira, Silvano Barbosa, Porto, Victor Bertollo Gomes, Ganem, Fabiana, de Almeida, Walquiria Aparecida Ferreira, Fantinato, Francieli Fontana Sutile Tardetti, Macário, Eduardo Marques, de Oliveira, Wanderson Kleber, Nogueira, Mauricio L., Pybus, Oliver G., Wu, Chieh-Hsi, Croda, Julio, Sabino, Ester C., and Faria, Nuno Rodrigues

Published
2020
Full Text
View/download PDF

35. Emergence of the Asian lineage of Zika virus in Angola: an outbreak investigation

Author

Hill, Sarah C, Vasconcelos, Jocelyne, Neto, Zoraima, Jandondo, Domingos, Zé-Zé, Líbia, Aguiar, Renato Santana, Xavier, Joilson, Thézé, Julien, Mirandela, Marinela, Micolo Cândido, Ana Luísa, Vaz, Filipa, Sebastião, Cruz dos Santos, Wu, Chieh-Hsi, Kraemer, Moritz U G, Melo, Adriana, Schamber-Reis, Bruno L F, de Azevedo, Girlene S, Tanuri, Amilcar, Higa, Luiza M, Clemente, Carina, da Silva, Sara Pereira, da Silva Candido, Darlan, Claro, Ingra M, Quibuco, Domingos, Domingos, Cristóvão, Pocongo, Bárbara, Watts, Alexander G, Khan, Kamran, Alcantara, Luiz Carlos Junior, Sabino, Ester C, Lackritz, Eve, Pybus, Oliver G, Alves, Maria-João, Afonso, Joana, and Faria, Nuno R

Published
2019
Full Text
View/download PDF

36. Predictors of mortality in patients with yellow fever: an observational cohort study

Author

Kallas, Esper G, D'Elia Zanella, Luiz Gonzaga F A B, Moreira, Carlos Henrique V, Buccheri, Renata, Diniz, Gabriela B F, Castiñeiras, Anna Carla P, Costa, Priscilla R, Dias, Juliana Z C, Marmorato, Mariana P, Song, Alice T W, Maestri, Alvino, Borges, Igor C, Joelsons, Daniel, Cerqueira, Natalia B, Santiago e Souza, Nathália C, Morales Claro, Ingra, Sabino, Ester C, Levi, José Eduardo, Avelino-Silva, Vivian I, and Ho, Yeh-Li

Published
2019
Full Text
View/download PDF

37. Author Correction: Spatial and temporal fluctuations in COVID-19 fatality rates in Brazilian hospitals

Author

Brizzi, Andrea, Whittaker, Charles, Servo, Luciana M. S., Hawryluk, Iwona, Prete, Jr, Carlos A., de Souza, William M., Aguiar, Renato S., Araujo, Leonardo J. T., Bastos, Leonardo S., Blenkinsop, Alexandra, Buss, Lewis F., Candido, Darlan, Castro, Marcia C., Costa, Silvia F., Croda, Julio, de Souza Santos, Andreza Aruska, Dye, Christopher, Flaxman, Seth, Fonseca, Paula L. C., Geddes, Victor E. V., Gutierrez, Bernardo, Lemey, Philippe, Levin, Anna S., Mellan, Thomas, Bonfim, Diego M., Miscouridou, Xenia, Mishra, Swapnil, Monod, Mélodie, Moreira, Filipe R. R., Nelson, Bruce, Pereira, Rafael H. M., Ranzani, Otavio, Schnekenberg, Ricardo P., Semenova, Elizaveta, Sonabend, Raphael, Souza, Renan P., Xi, Xiaoyue, Sabino, Ester C., Faria, Nuno R., Bhatt, Samir, and Ratmann, Oliver

Published
2022
Full Text
View/download PDF

38. Oral lesion and microbiome diversity in COVID-19 hospitalized patients.

Author

Costa, Silvia, primary, Fonseca, Joyce Vanessa Da Silva, additional, Scaccia, Nazareno, additional, Jales, Sumatra Melo Da Costa Pereira, additional, Torres, Pablo Andres Munoz, additional, Franco, Lucas Augusto Moyses, additional, Migliorati, Cesar Augusto, additional, Stewart, Bernal, additional, Lunis, Alessandra, additional, Zerbinati, Rodrigo Melim, additional, Pilleggii, Roberta, additional, Braz-Silva, Paulo Henrique, additional, and Sabino, Ester C., additional

Published
2023
Full Text
View/download PDF

39. Detailed characterization of Redondovirus in saliva of SARS-CoV-2-infected individuals in Sao Paulo, Brazil

Author

Charlys da Costa, Antonio, primary, Mendes-Correa, Maria C., additional, Tozetto-Mendoza, Tania Regina, additional, Villas-Boas, Lucy S., additional, de Paula, Anderson Vicente, additional, Paiao, Heuder Gustavo Oliveira, additional, Leal, Fabio E., additional, Ferreira, Noely E., additional, Honorato, Layla, additional, Leal, Elcio, additional, Grandi, Giuliano, additional, dos Santos Morais, Vanessa, additional, Manuli, Erika R., additional, Sabino, Ester C., additional, and Witkin, Steven S., additional

Published
2023
Full Text
View/download PDF

41. Clonal hematopoiesis in sickle cell disease

Author

Liggett, L. Alexander, Cato, Liam D., Weinstock, Joshua S., Zhang, Yingze, Nouraie, S. Mehdi, Gladwin, Mark T., Garrett, Melanie E., Ashley-Koch, Allison, Telen, Marilyn J., Custer, Brian, Kelly, Shannon, Dinardo, Carla L., Sabino, Ester C., Loureiro, Paula, Carneiro-Proietti, Anna B., Maximo, Claudia, Reiner, Alexander P., Abecasis, Gongalo R., Williams, David A., Natarajan, Pradeep, Bick, Alexander G., and Sankaran, Vijay G.

Subjects
Gene mutations -- Research, Sickle cell anemia -- Genetic aspects -- Development and progression, Hematopoiesis -- Research, Leukemia -- Risk factors -- Genetic aspects, Health care industry
Abstract

BACKGROUND. Curative gene therapies for sickle cell disease (SCD) are currently undergoing clinical evaluation. The occurrence of myeloid malignancies in these trials has prompted safety concerns. Individuals with SCD are predisposed to myeloid malignancies, but the underlying causes remain undefined. Clonal hematopoiesis (CH) is a premalignant condition that also confers significant predisposition to myeloid cancers. While it has been speculated that CH may play a role in SCD-associated cancer predisposition, limited data addressing this issue have been reported. METHODS. Here, we leveraged 74,190 whole-genome sequences to robustly study CH in SCD. Somatic mutation calling methods were used to assess CH in all samples and comparisons between individuals with and without SCD were performed. RESULTS. While we had sufficient power to detect a greater than 2-fold increased rate of CH, we found no detectable variation in rate or clone properties between individuals affected by SCD and controls. The rate of CH in individuals with SCD was unaltered by hydroxyurea use. CONCLUSIONS. We did not observe an increased risk for acquiring detectable CH in SCD, at least as measured by whole-genome sequencing. These results should help guide ongoing efforts and further studies that seek to better define the risk factors underlying myeloid malignancy predisposition in SCD and help ensure that curative therapies can be more safely applied. FUNDING. New York Stem Cell Foundation and the NIH., Introduction In addition to the reduced life expectancy from disease complications (1), individuals with sickle cell disease (SCD) are estimated to have an approximately 3- to 10-fold increased lifetime risk [...]

Published
2022
Full Text
View/download PDF

43. Response to Letters Regarding Article, “Ten-Year Incidence of Chagas Cardiomyopathy Among Asymptomatic, Trypanosoma cruzi–Seropositive Former Blood Donors”

Author

Sabino, Ester C, Ribeiro, Antonio L, Salemi, Vera MC, Ianni, Barbara M, Nastari, Luciano, Fernandes, Fabio, Di Lorenzo Oliveira, Claudia, Antunes, Andre P, Menezes, Marcia M, Patavino, Giuseppina M, Capuani, Ligia, de Almeida-Neto, Cesar, Sachdev, Vandana, Carrick, Danielle M, Wright, David, Kavounis, Katherine, Gonzalez, Thelma T, Custer, Brian, Busch, Michael P, Murphy, Edward L, and Carneiro-Proietti, Anna-Barbara

Subjects
Good Health and Well Being, Asymptomatic Diseases, Blood Donors, Chagas Cardiomyopathy, Humans, Male, Trypanosoma cruzi, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Public Health and Health Services, Cardiovascular System & Hematology
Published
2013

44. Ten-Year Incidence of Chagas Cardiomyopathy Among Asymptomatic Trypanosoma cruzi–Seropositive Former Blood Donors

Author

Sabino, Ester C, Ribeiro, Antonio L, Salemi, Vera MC, Di Lorenzo Oliveira, Claudia, Antunes, Andre P, Menezes, Marcia M, Ianni, Barbara M, Nastari, Luciano, Fernandes, Fabio, Patavino, Giuseppina M, Sachdev, Vandana, Capuani, Ligia, de Almeida-Neto, Cesar, Carrick, Danielle M, Wright, David, Kavounis, Katherine, Goncalez, Thelma T, Carneiro-Proietti, Anna Barbara, Custer, Brian, Busch, Michael P, and Murphy, Edward L

Subjects
Cardiovascular, Clinical Research, Rare Diseases, Vector-Borne Diseases, Infectious Diseases, Heart Disease, Good Health and Well Being, Adult, Asymptomatic Diseases, Blood Donors, Brazil, Chagas Cardiomyopathy, Cohort Studies, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Retrospective Studies, Time Factors, Trypanosoma cruzi, Young Adult, blood donors, Chagas cardiomyopathy, Chagas disease, incidence, National Heart, Lung, and Blood Institute Retrovirus Epidemiology Donor Study-II (REDS-II), International Component, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Public Health and Health Services, Cardiovascular System & Hematology
Abstract

BackgroundVery few studies have measured disease penetrance and prognostic factors of Chagas cardiomyopathy among asymptomatic Trypanosoma cruzi-infected persons.Methods and resultsWe performed a retrospective cohort study among initially healthy blood donors with an index T cruzi-seropositive donation and age-, sex-, and period-matched seronegatives in 1996 to 2002 in the Brazilian cities of São Paulo and Montes Claros. In 2008 to 2010, all subjects underwent medical history, physical examination, ECGs, and echocardiograms. ECG and echocardiogram results were classified by blinded core laboratories, and records with abnormal results were reviewed by a blinded panel of 3 cardiologists who adjudicated the outcome of Chagas cardiomyopathy. Associations with Chagas cardiomyopathy were tested with multivariate logistic regression. Mean follow-up time between index donation and outcome assessment was 10.5 years for the seropositives and 11.1 years for the seronegatives. Among 499 T cruzi seropositives, 120 (24%) had definite Chagas cardiomyopathy, and among 488 T cruzi seronegatives, 24 (5%) had cardiomyopathy, for an incidence difference of 1.85 per 100 person-years attributable to T cruzi infection. Of the 120 seropositives classified as having Chagas cardiomyopathy, only 31 (26%) presented with ejection fraction

Published
2013

45. Electrocardiographic Abnormalities in Trypanosoma cruzi Seropositive and Seronegative Former Blood Donors

Author

Ribeiro, Antonio L, Sabino, Ester C, Marcolino, Milena S, Salemi, Vera MC, Ianni, Barbara M, Fernandes, Fábio, Nastari, Luciano, Antunes, André, Menezes, Márcia, Oliveira, Cláudia Di Lorenzo, Sachdev, Vandana, Carrick, Danielle M, Busch, Michael P, and Murphy, Eduard L

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Heart Disease, Cardiovascular, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Good Health and Well Being, Adult, Antibodies, Protozoan, Blood Donors, Brazil, Chagas Cardiomyopathy, Electrocardiography, Female, Heart, Humans, Male, Middle Aged, Retrospective Studies, Trypanosoma cruzi, NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II), International Component, Biological Sciences, Medical and Health Sciences, Tropical Medicine, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundBlood donor screening leads to large numbers of new diagnoses of Trypanosoma cruzi infection, with most donors in the asymptomatic chronic indeterminate form. Information on electrocardiogram (ECG) findings in infected blood donors is lacking and may help in counseling and recognizing those with more severe disease.ObjectivesTo assess the frequency of ECG abnormalities in T.cruzi seropositive relative to seronegative blood donors, and to recognize ECG abnormalities associated with left ventricular dysfunction.MethodsThe study retrospectively enrolled 499 seropositive blood donors in São Paulo and Montes Claros, Brazil, and 483 seronegative control donors matched by site, gender, age, and year of blood donation. All subjects underwent a health clinical evaluation, ECG, and echocardiogram (Echo). ECG and Echo were reviewed blindly by centralized reading centers. Left ventricular (LV) dysfunction was defined as LV ejection fraction (EF)

Published
2013

46. Human T-Lymphotropic Virus Type 1 and Type 2 Seroprevalence, Incidence, and Residual Transfusion Risk Among Blood Donors in Brazil During 2007–2009

Author

Carneiro-Proietti, Anna Bárbara F, Sabino, Ester C, Leão, Silvana, Salles, Nanci A, Loureiro, Paula, Sarr, Moussa, Wright, David, Busch, Michael, Proietti, Fernando A, and Edward L. Murphy, for the NHLBI Retrovirus Epidemiology Donor Study-II

Subjects
Rare Diseases, Aetiology, 2.2 Factors relating to the physical environment, Infection, Adolescent, Adult, Blood Donors, Brazil, Donor Selection, Female, HTLV-I Antibodies, HTLV-I Infections, HTLV-II Antibodies, HTLV-II Infections, Humans, Immunoenzyme Techniques, Incidence, Male, Mass Screening, Middle Aged, Prevalence, Risk Factors, Sentinel Surveillance, Transfusion Reaction, Young Adult, NHLBI Retrovirus Epidemiology Donor Study-II (Reds-II), International Component, Clinical Sciences, Virology
Abstract

Human T-lymphotropic virus type 1/2 (HTLV-1/2) infection is endemic in Brazil but representative donor prevalence and incidence data are lacking. All blood donations (2007-2009) from three blood centers in Brazil were studied. Samples reactive on one HTLV screening test (EIA) were retested with a different EIA; dual EIA reactivity correlated strongly with a confirmatory Western blot. Prevalence, incidence, and residual transfusion risk were calculated. Among 281,760 first-time donors, 363 were positive for HTLV on both EIAs (135 per 10(5), 95% CI 122-150). Prevalence differed considerably by region, from 83 to 222 per 10(5). Overall incidence rate was 3.6/10(5) person-years and residual transfusion risk was 5.0/10(6) per blood unit transfused. The logistic regression model showed significant associations with: age [adjusted odds ratio (aOR)=5.23 for age 50+ vs.

Published
2012

47. Vasovagal reactions in whole blood donors at three REDS‐II blood centers in Brazil

Author

Gonçalez, Thelma T, Sabino, Ester C, Schlumpf, Karen S, Wright, David J, Leao, Silvana, Sampaio, Divaldo, Takecian, Pedro L, Proitetti, Anna B, Murphy, Edward, Busch, Michael, Custer, Brian, and Study‐II, International Component for the NHLBI Retrovirus Epidemiology Donor

Subjects
Patient Safety, Adolescent, Adult, Aged, Blood Donors, Brazil, Cross-Sectional Studies, Female, Humans, Logistic Models, Male, Middle Aged, Syncope, Vasovagal, NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II), International Component, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Immunology, Cardiovascular System & Hematology
Abstract

BackgroundIn Brazil little is known about adverse reactions during donation and the donor characteristics that may be associated with such events. Donors are offered snacks and fluids before donating and are required to consume a light meal after donation. For these reasons the frequency of reactions may be different than those observed in other countries.Study design and methodsA cross-sectional study was conducted of eligible whole blood donors at three large blood centers located in Brazil between July 2007 and December 2009. Vasovagal reactions (VVRs) along with donor demographic and biometric data were collected. Reactions were defined as any presyncopal or syncopal event during the donation process. Multivariable logistic regression was performed to identify predictors of VVRs.ResultsOf 724,861 donor presentations, 16,129 (2.2%) VVRs were recorded. Rates varied substantially between the three centers: 53, 290, and 381 per 10,000 donations in Recife, São Paulo, and Belo Horizonte, respectively. Although the reaction rates varied, the donor characteristics associated with VVRs were similar (younger age [18-29 years], replacement donors, first-time donors, low estimated blood volume [EBV]). In multivariable analysis controlling for differences between the donor populations in each city younger age, first-time donor status, and lower EBV were the factors most associated with reactions.ConclusionFactors associated with VVRs in other locations are also evident in Brazil. The difference in VVR rates between the three centers might be due to different procedures for identifying and reporting the reactions. Potential interventions to reduce the risk of reactions in Brazil should be considered.

Published
2012

49. The impact of simple donor education on donor behavioral deferral and infectious disease rates in São Paulo, Brazil

Author

Gonçalez, Thelma T, Sabino, Ester C, Salles, Nanci Alves, De Almeida‐Neto, Cesar, Mendrone‐Jr, Alfredo, Dorlhiac‐Laccer, Pedro E, Liu, Jing, Murphy, Edward L, and Schreiber, George B

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, HIV/AIDS, Infectious Diseases, Clinical Research, Good Health and Well Being, Adult, Aged, Blood Banks, Blood Donors, Brazil, Communicable Diseases, Confidentiality, Disease Transmission, Infectious, Educational Status, Female, HIV Infections, Health Knowledge, Attitudes, Practice, Humans, Male, Middle Aged, Pamphlets, Risk Assessment, Risk Management, Transfusion Reaction, Urban Population, REDS-II International Brazil Study, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Immunology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundStudies have shown that human immunodeficiency virus (HIV) residual risk is higher in Brazilian than in US and European blood donors, probably due to failure to defer at-risk individuals in Brazil. This study assessed the impact of an educational brochure in enhancing blood donors' knowledge about screening test window phase and reducing at-risk individuals from donating.Study design and methodsThis trial compared an educational intervention with a blood center's usual practice. The brochure was distributed in alternating months to all donors. After donating, sampled participants completed two questions about their HIV window period knowledge. The impact on HIV risk deferral, leaving without donation, confidential unit exclusion (CUE) use, and test positivity was also analyzed.ResultsFrom August to November 2007 we evaluated 33,940 donations in the main collection center of Fundação Pró-Sangue/Hemocentro de São Paulo in São Paulo, Brazil. A significant (p < 0.001) pamphlet effect was found on correct responses to both questions assessing HIV window phase knowledge (68.1% vs. 52.9%) and transfusion risk (91.1% vs. 87.2%). After adjusting for sex and age, the pamphlet effect was strongest for people with more than 8 years of education. There was no significant pamphlet effect on HIV risk deferral rate, leaving without donation, use of CUE, or infectious disease rates.ConclusionWhile the educational pamphlet increased window period knowledge, contrary to expectations this information alone was not enough to make donors self-defer or acknowledge their behavioral risk.

Published
2010

50. Demographic profile of blood donors at three major Brazilian blood centers: results from the International REDS‐II study, 2007 to 2008

Author

Carneiro‐Proietti, Anna Bárbara, Sabino, Ester C, Sampaio, Divaldo, Proietti, Fernando A, Gonçalez, Thelma T, Oliveira, Cláudia DL, Ferreira, João E, Liu, Jing, Custer, Brian, Schreiber, George B, Murphy, Edward L, and Busch, Michael P

Subjects
Age Distribution, Age Factors, Aged, 80 and over, Blood Donors, Blood Transfusion, Blood-Borne Pathogens, Brazil, Demography, Female, Health Policy, Humans, Male, Public Health, Sex Characteristics, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Immunology, Cardiovascular System & Hematology
Abstract

BackgroundThe profile of blood donors changed dramatically in Brazil over the past 20 years, from remunerated to nonremunerated and then from replacement to community donors. Donor demographic data from three major blood centers establish current donation profiles in Brazil, serving as baseline for future analyses and tracking longitudinal changes in donor characteristics.Study design and methodsData were extracted from the blood center, compiled in a data warehouse, and analyzed. Population data were obtained from the Brazilian census.ResultsDuring 2007 to 2008, there were 615,379 blood donations from 410,423 donors. A total of 426,142 (69.2%) were from repeat (Rpt) donors and 189,237 (30.8%) were from first-time (FT) donors. Twenty percent of FT donors returned to donate in the period. FT donors were more likely to be younger, and Rpt donors were more likely to be community donors. All were predominantly male. Replacement donors still represent 50% of FT and 30% of Rpt donors. The mean percentage of the potentially general population who were donors was approximately 1.2% for the three centers (0.7, 1.5, and 3.1%). Adjusting for the catchment's area, the first two were 2.1 and 1.6%.ConclusionsDonors in the three Brazilian centers tended to be younger with a higher proportion of males than in the general population. Donation rates were lower than desirable. There were substantial differences in sex, age, and community/replacement status by center. Studies on the safety, donation frequencies, and motivations of donors are in progress to orient efforts to enhance the availability of blood.

Published
2010

Catalog

Books, media, physical & digital resources
See catalog results