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19 results on '"Sabakhtarashvili MA"'

1. Somatotropin secretion in hyperprolactinemia

Author

Sabakhtarashvili Ma, Gorgoshidze Bv, Kurashvili Rb, Dundua Mg, and É. G. Veinberg

Subjects
Adenoma, Adult, Blood Glucose, medicine.medical_specialty, Somatotropic cell, Adolescent, Glucose challenge, Lactation Disorders, Biology, Basal (phylogenetics), Pituitary adenoma, Pregnancy, Internal medicine, medicine, Humans, In patient, Pituitary Neoplasms, Circadian rhythm, Pituitary microadenoma, Somatotropin secretion, General Neuroscience, Galactorrhea, medicine.disease, Circadian Rhythm, Prolactin, Endocrinology, Growth Hormone, Female
Abstract

1. HPL patients characteristically show depressed basal levels of STH. 2. Patients with HPL and radiologically confirmed pituitary adenoma show an altered response of the somatotropic structures to glucose challenge and marked circadian variations in the STH circadian pattern. 3. In patients without a radiological sign of pituitary adenoma STH levels are depressed but the circadian rhythm resembles the normal pattern; the STH fails to show a response to a glucose load and in GTT the STH concentration plot is flattened. 4. The severity of somatotropic functional alteration in HPL is not as important as the nature of the pathologic substrate which underlies the disease. 5. Studies on the circadian STH pattern and its fluctuations in GTT may provide objective criteria in the diagnosis of pituitary microadenoma.

Published
1983

2. [Cortisol secretion in patients with hyperprolactinemia syndrome].

Author

Veinberg EG, Kurashvili RB, Sabakhtarashvili MA, Gorgoshidze BV, and Dundua MG

Subjects
Adenoma physiopathology, Adolescent, Adult, Circadian Rhythm, Female, Humans, Pituitary Neoplasms physiopathology, Hydrocortisone metabolism, Prolactin blood
Published
1984

4. [Diagnostic value of roentgenography in the hyperprolactinemic syndrome].

Author

Veĭnberg EG, Vepkhvadze RIa, Kapanadze BB, Sabakhtarashvili MA, and Gorgoshidze BV

Subjects
Adenoma diagnostic imaging, Adolescent, Adult, Female, Fibrocystic Breast Disease diagnostic imaging, Humans, Radiography, Syndrome, Pituitary Neoplasms diagnostic imaging, Prolactin metabolism
Published
1984

5. [hyperprolactinemia syndrome].

Author

Sabakhtarashvili MA and Gorgoshidze BV

Subjects
Adenoma etiology, Adenoma metabolism, Adult, Amenorrhea diagnosis, Amenorrhea physiopathology, Circadian Rhythm, Estrogens physiology, Female, Follicle Stimulating Hormone physiology, Galactorrhea diagnosis, Galactorrhea physiopathology, Humans, Hypothalamo-Hypophyseal System metabolism, Infant, Newborn, Infertility, Female diagnosis, Infertility, Female physiopathology, Luteinizing Hormone physiology, Male, Pituitary Neoplasms diagnosis, Pituitary Neoplasms etiology, Pituitary Neoplasms metabolism, Pregnancy, Prolactin metabolism, Prolactin Release-Inhibiting Factors physiology, Syndrome, Thyrotropin-Releasing Hormone physiology, Prolactin blood
Published
1982

7. [Characteristics of growth hormone secretion in the hyperprolactinemia syndrome].

Author

Gorgoshidze BV, Sabakhtarashvili MA, Veĭnberg EG, Kurashvili RB, and Dundua MG

Subjects
Adenoma diagnosis, Adenoma physiopathology, Adolescent, Adult, Circadian Rhythm, Female, Humans, Pituitary Gland, Anterior physiopathology, Pituitary Neoplasms diagnosis, Pituitary Neoplasms physiopathology, Syndrome, Growth Hormone metabolism, Prolactin blood
Abstract

A low basal level of growth hormone (GH) was determined by radioimmunoassay in studying GH basal content, the circadian rhythm and the response to glucose load in patients with hyperprolactinemia. In subjects with hypophyseal adenoma, an anomalous GH response to glucose load and the disturbance of its circadian rhythm are seen. In patients not suffering from hypophyseal adenoma, the circadian curve of GH content is similar to the normal one on a lower level. A pronounced GH response to glucose load is absent in these patients.

Published
1983

8. [Carbohydrate metabolism in patients with hyperprolactinemia syndrome].

Author

Sabakhtarashvili MA, Gorgoshidze BV, Veĭnberg EG, Kurashvili RB, and Dundua MG

Subjects
Adolescent, Adult, Circadian Rhythm, Female, Glucose Tolerance Test, Humans, Pregnancy, Syndrome, Blood Glucose metabolism, Galactorrhea blood, Insulin blood, Lactation Disorders blood, Prolactin metabolism
Published
1983

9. [Serotonin, histamine and catecholamine levels in patients with the hyperprolactinemia syndrome].

Author

Veĭnberg EG, Vetrogon FG, Sabakhtarashvili MA, and Marganiia IKh

Subjects
Adenoma blood, Adenoma metabolism, Adolescent, Adult, Chronic Disease, Female, Galactorrhea blood, Humans, Menstruation Disturbances blood, Pituitary Neoplasms blood, Pituitary Neoplasms metabolism, Prolactin metabolism, Catecholamines blood, Histamine blood, Hyperprolactinemia blood, Serotonin blood
Abstract

A total of 76 patients aged 18-39 with hyperprolactinemia were studied for the blood levels of serotonin and histamine and for the urinary ones of epinephrine, norepinephrine, dopa and dopamine. Blood levels of serotonin and histamine were recorded increased whereas the urinary levels of catecholamines were decreased. No correlation was shown between the intensity in the production of lactogenic hormone and those abnormalities found in the levels of the above mentioned amino groups. The shifts observed were supposed to reflect those general tendencies which took place in the central regulatory mechanisms of the gonadal system in patients with excessive production of lactogenic hormone.

Published
1986

10. [Hypothalamic syndrome of puberty (a review of the literature)].

Author

Sabakhtarashvili MA

Subjects
17-Hydroxycorticosteroids blood, Adolescent, Brain Diseases physiopathology, Estrogens metabolism, Female, Glucocorticoids physiology, Growth Hormone metabolism, Humans, Hypertension etiology, Hypertension physiopathology, Islets of Langerhans physiopathology, Luteinizing Hormone metabolism, Male, Obesity physiopathology, Sex Characteristics, Syndrome, Thyroid Gland physiopathology, Brain Diseases etiology, Hypothalamus physiopathology, Obesity etiology, Puberty
Published
1978

14. Somatotropin secretion in hyperprolactinemia.

Author

Gorgoshidze BV, Sabakhtarashvili MA, Veinberg EG, Kurashvili RB, and Dundua MG

Subjects
Adolescent, Adult, Blood Glucose metabolism, Circadian Rhythm, Female, Humans, Pregnancy, Adenoma blood, Galactorrhea blood, Growth Hormone blood, Lactation Disorders blood, Pituitary Neoplasms blood, Prolactin blood
Published
1983
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17. [Clinical manifestations of primary hypeprolactinemia in women].

Author

Veĭnberg EG, Markarova OS, Sabakhtarashvili MA, and Gorgoshidze BV

Subjects
Adenoma complications, Adolescent, Adult, Circadian Rhythm, Female, Humans, Pituitary Neoplasms complications, Pregnancy, Galactorrhea etiology, Lactation Disorders etiology, Menstruation Disturbances etiology, Prolactin metabolism
Published
1982

19. [Clinical course and the effectiveness of conservative treatment of prolactin-secreting pituitary adenoma].

Author

Sabakhtarashvili MA, Veĭnberg EG, Kurashvili RB, and Kanchaveli ZSh

Subjects
Adenoma blood, Adenoma surgery, Adolescent, Adult, Bromocriptine therapeutic use, Female, Humans, Hyperprolactinemia therapy, Hypophysectomy, Pituitary Neoplasms blood, Pituitary Neoplasms surgery, Prolactin antagonists & inhibitors, Prolactin blood, Adenoma metabolism, Hyperprolactinemia etiology, Pituitary Neoplasms metabolism, Prolactin metabolism
Abstract

Forty-eight women with prolactin-secreting adenomas of the hypophysis and 22 patients with suspected microadenomas, aged 16 to 38, were examined. The highest blood prolactin levels and the most manifest symptoms were revealed in the patients with x-ray evidence of hypophyseal macroadenoma. Prolactin levels were lower, though still elevated, in the cases with small adenomas. In the cases with high prolactin levels but without x-ray signs of hypophyseal adenoma the clinical symptoms were less manifest. LH concentrations were significantly reduced in all the patients. Seven patients in whom parlodel therapy was ineffective were operated on. In the rest parlodel therapy, carried out for 1-2 years, was conducive to stabilization of the tumor process, despite a recurrence of hyperprolactinemia.

Published
1989

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