Search

Your search keyword '"Saara M Valkama"' showing total 5 results
Start Over Author "Saara M Valkama"
5 results on '"Saara M Valkama"'

1. Maternal vitamin D status, gestational diabetes and infant birth size

Author

Helena H. Hauta-alus, Heli T. Viljakainen, Elisa M. Holmlund-Suila, Maria Enlund-Cerullo, Jenni Rosendahl, Saara M. Valkama, Otto M. Helve, Timo K. Hytinantti, Outi M. Mäkitie, and Sture Andersson

Subjects
Maternal vitamin D status, Newborn vitamin D status, 25-hydroxy vitamin D concentration, Gestational diabetes mellitus, Birth size, Birth weight, Gynecology and obstetrics, RG1-991
Abstract

Abstract Background Maternal vitamin D status has been associated with both gestational diabetes mellitus (GDM) and fetal growth restriction, however, the evidence is inconsistent. In Finland, maternal vitamin D status has improved considerably due to national health policies. Our objective was to compare maternal 25-hydroxy vitamin D concentrations [25(OH)D] between mothers with and without GDM, and to investigate if an association existed between maternal vitamin D concentration and infant birth size. Methods This cross-sectional study included 723 mother-child pairs. Mothers were of Caucasian origin, and infants were born at term with normal birth weight. GDM diagnosis and birth size were obtained from medical records. Maternal 25(OH)D was determined on average at 11 weeks of gestation in pregnancy and in umbilical cord blood (UCB) at birth. Results GDM was observed in 81 of the 723 women (11%). Of the study population, 97% were vitamin D sufficient [25(OH)D ≥ 50 nmol/L]. There was no difference in pregnancy 25(OH)D concentration between GDM and non-GDM mothers (82 vs 82 nmol/L, P = 0.99). Regression analysis confirmed no association between oral glucose tolerance test results and maternal 25(OH)D (P > 0.53). Regarding the birth size, mothers with optimal pregnancy 25(OH)D (≥ 80 nmol/L) had heavier newborns than those with suboptimal pregnancy 25(OH)D (P = 0.010). However, mothers with optimal UCB 25(OH)D had newborns with smaller head circumference than those with suboptimal 25(OH)D (P = 0.003), which was further confirmed as a linear association (P = 0.024). Conclusions Maternal vitamin D concentration was similar in mothers with and without GDM in a mostly vitamin D sufficient population. Associations between maternal vitamin D status and birth size were inconsistent. A sufficient maternal vitamin D status, specified as 25(OH)D above 50 nmol/L, may be a threshold above which the physiological requirements of pregnancy are achieved. Trial registration The project protocol is registered in ClinicalTrials.gov in November 8, 2012 ( NCT01723852 ).

Published
2017
Full Text
View/download PDF

2. Collagen X Biomarker (CXM), Linear Growth, and Bone Development in a Vitamin D Intervention Study in Infants

Author

Helena H Hauta‐alus, Elisa M Holmlund‐Suila, Saara M Valkama, Maria Enlund‐Cerullo, Jenni Rosendahl, Ryan F Coghlan, Sture Andersson, Outi Mäkitie, CAMM - Research Program for Clinical and Molecular Metabolism, HUS Children and Adolescents, Research Programs Unit, Children's Hospital, University of Helsinki, Clinicum, HUSLAB, and Lastentautien yksikkö

Subjects
Bone Development, PROTEINS, Endocrinology, Diabetes and Metabolism, LINEAR GROWTH, Infant, CHILDREN, VELOCITY, EARLY CHILDHOOD, VITAMIN D, HORMONE, Bone Density, Child, Preschool, 3121 General medicine, internal medicine and other clinical medicine, Humans, Orthopedics and Sports Medicine, Collagen, COLLAGEN X BIOMARKER, Child, BONE, Biomarkers, Cholecalciferol
Abstract

Publisher Copyright: © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR). Collagen X biomarker (CXM) is suggested to be a biomarker of linear growth velocity. However, early childhood data are limited. This study examines the relationship of CXM to the linear growth rate and bone development, including the possible modifying effects of vitamin D supplementation. We analyzed a cohort of 276 term-born children participating in the Vitamin D Intervention in Infants (VIDI) study. Infants received 10 μg/d (group-10) or 30 μg/d (group-30) vitamin D3 supplementation for the first 2 years of life. CXM and length were measured at 12 and 24 months of age. Tibial bone mineral content (BMC), volumetric bone mineral density (vBMD), cross-sectional area (CSA), polar moment of inertia (PMI), and periosteal circumference (PsC) were measured using peripheral quantitative computed tomography (pQCT) at 12 and 24 months. We calculated linear growth as length velocity (cm/year) and the growth rate in length (SD unit). The mean (SD) CXM values were 40.2 (17.4) ng/mL at 12 months and 38.1 (12.0) ng/mL at 24 months of age (p = 0.12). CXM associated with linear growth during the 2-year follow-up (p = 0.041) but not with bone (p = 0.53). Infants in group-30 in the highest tertile of CXM exhibited an accelerated mean growth rate in length compared with the intermediate tertile (mean difference [95% CI] −0.50 [−0.98, −0.01] SD unit, p = 0.044) but not in the group-10 (p = 0.062) at 12 months. Linear association of CXM and growth rate until 12 months was weak, but at 24 months CXM associated with both length velocity (B for 1 increment of √CXM [95% CI] 0.32 [0.12, 0.52] cm/yr, p = 0.002) and growth rate in length (0.20 [0.08, 0.32] SD unit, p = 0.002). To conclude, CXM may not reliably reflect linear growth from birth to 12 months of age, but its correlation with growth velocity improves during the second year of life.

Published
2022

4. Food and Nutrient Intake and Nutrient Sources in 1-Year-Old Infants in Finland: A Cross-Sectional Analysis

Author

Helena H. Hauta-alus, Liisa Korkalo, Elisa M. Holmlund-Suila, Jenni Rosendahl, Saara M. Valkama, Maria Enlund-Cerullo, Otto M. Helve, Timo K. Hytinantti, Outi M. Mäkitie, Sture Andersson, and Heli T. Viljakainen

Subjects
infant nutrition, breastfeeding, food consumption, nutrient intake, Nutrition. Foods and food supply, TX341-641
Abstract

The infant diet has short- and long-term health consequences. Updated data regarding the dietary intake of Finnish infants are lacking. The objectives of this study were to describe infant food and nutrient intake and to identify food sources of the nutrients. Altogether, 739 healthy infants were studied. Dietary intake and breastfeeding frequency were assessed with a three-day food record at 1 year of age. Dietary intake was calculated separately for non-breastfed and breastfed infants. One-third (36%) of the infants were partially breastfed and 95% consumed mass-produced baby foods. The infants’ diet consisted mainly of infant formula, dairy milk, porridges, fruit and berry foods, and meat dishes. The mean vegetable, fruit and berry consumption was 199 g/day. Most nutrient intakes were adequate except for fat, linoleic acid, vitamin D and iron from food. Mean sucrose intake, as a percentage of total energy intake (E%), was 5–6 E%. High protein intake (>20 E%) was observed in 19% of non-breastfed infants. Overall, the infants’ diet was favorable since vegetable and fruit consumption was reasonably high and nutrient intake was mostly adequate. However, the fat intake was lower, and protein intake higher than recommended. Increasing the consumption of vegetable oils and reducing the intake of red meat and dairy milk may further improve the diet of 1-year-olds.

Published
2017
Full Text
View/download PDF

5. Iron status in early childhood is modified by diet, sex and growth: Secondary analysis of a randomized controlled vitamin D trial

Author

Elisa M. Holmlund-Suila, Helena H. Hauta-alus, Maria Enlund-Cerullo, Jenni Rosendahl, Saara M. Valkama, Sture Andersson, Outi Mäkitie, Clinicum, HUS Children and Adolescents, Children's Hospital, CAMM - Research Program for Clinical and Molecular Metabolism, HUSLAB, Faculty of Medicine, Lastentautien yksikkö, and Medicum

Subjects
Male, YOUNG-CHILDREN, Toddler, EUROPE, INFANTS, Nutritional Status, DIAGNOSIS, Critical Care and Intensive Care Medicine, Diet Surveys, SERUM, Sex Factors, INFLAMMATION, Risk Factors, Prevalence, Humans, Vitamin D, Finland, Ferritin, Nutrition and Dietetics, Anemia, Iron-Deficiency, Iron deficiency, Infant, Anemia, Diet, DEFICIENCY, Child, Preschool, Ferritins, Female, 3143 Nutrition
Abstract

During early childhood the risk of iron deficiency (ID) is high. Serum ferritin serves as a marker of iron status. We explored prevalence of ID and iron deficiency anemia (IDA), and identified determinants of iron status in infants and toddlers.We performed a secondary analysis of the Vitamin D intervention in infants (VIDI) study in Finnish healthy term infants. According to study protocol, at 12- and 24-months of age iron status, growth and dietary intakes were evaluated. ID was defined as serum ferritin10 μg/L and IDA as serum ferritin10 μg/L and Hb112 g/L. For the present study, altogether 766 children provided data (N = 498 infants at 12 months, N = 508 toddlers at 24 months).ID prevalence increased from 14% in infants to 20% in toddlers. IDA prevalence was 3% at both time points. In infants, ID and IDA were more common in boys than in girls (19% vs. 9%, p = 0.001 and 5% vs. 1%, p = 0.039) but no sex-difference in toddlers was observed. Of infants, 30% had daily iron intake below average requirement of 5 mg/day. Higher daily iron intake per body weight (mg/kg) independently associated with higher infant serum ferritin (B (95% CI) 0.30 (0.04, 0.56), p = 0.026). Correlation between iron intake and ferritin was stronger in infants with ID than in infants without ID. Breastfeeding was more common (63% vs. 35%, p 0.001) among ID infants than in infants without ID. In toddlers, frequent consumption of milk products independently associated with lower ferritin (B (95% CI) -0.03 (-0.05, -0.01), p = 0.001). Consumption of meat and fish associated with better iron status. Serum ferritin at both time points associated with duration of gestation and growth. The association of growth and ferritin was age-dependent in boys, while in girls, faster growth associated consistently with lower ferritin.In Northern European healthy infants and toddlers ID is common. The intake of iron remains below recommendations and food consumption and iron intake associate with iron status. Further studies are warranted to assess significance of ID on child development and clinical health outcomes. The project protocol is registered at ClinicalTrials.gov: NCT01723852.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results