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Due to the side effects of chemical drugs, recent studies have targeted new therapeutic approach using natural bioactive molecules. The purpose of the current study was to explore, for the first time, the cardiopreventive capacity of Eucalyptus torquata seeds extract (ETS) against myocardial infarction induced by Isoproterenol (ISO) in rats. The phytochemical profile was also targeted. The LC-MS/MS analysis revealed the presence of 53 metabolites belonging to hydroxybenzoic acids, lignans, flavonoids, phloroglucinols, oxocins, organic acids, fatty acids, amino acids, and sugars. The in vivofindings showed that ETS supplementation for 28 days significantly attenuated the cardiotoxicity in adult rats by ameliorating the electrocardiographic pattern (ECG), and reducing the activity of LDH, AST, CK-MB, and troponin-T content compared to the infracted group. Furthermore, ETS reduced the cardiac oxidative stress generated by ISO injection via inhibiting lipid peroxidation and ameliorating the activities of enzymatic antioxidants (SOD, and CAT). Additionally, ETS supplementation attenuated the DNA fragmentation and improved the ultrastructural changes in cardiac tissue. The amelioration of the lipid level (TG, TC, LDL-C, and HDL-C), highlighted the antihyperlipidemic action of ETS. The positive effect of the studied extract against ISO-induced cardiac damage could be related to the bioactive compounds, known as effective antioxidant molecules. The current study provides a preliminary pharmacological support for a potential medicinal application of ETS against cardiovascular pathology.