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Additive manufacturing (AM) technology offers a streamlined approach to producing intricate components, reducing both time and costs. Lattice structures play a crucial role in optimising design space by proposing lattices that evaluate a broad spectrum of effective thermal and mechanical properties for building applications. This study aims to assess the impact of lattice topology and variations in the number of unit cells on the K-value, U-value, and compression strength of additively manufactured (AM) polymer lattices. The polymer lattice patterns were created using commercially available 3D printers and PLA polymer filaments. Thermal properties were characterised using a commercial heat flow meter (HFM), and hot-box calorimetry was employed to determine the K-value and U-value, respectively. Additionally, a universal material testing machine was used to investigate the compression strength of all specimens. Based on experimental findings, a scaling law was employed to correlate the effective thermal conductivities of various polymer lattice topologies, estimating the U-value of each one. Furthermore, the study examined how AM process parameters influenced the U-value of polymer lattices. The results indicated that lattice topology and relative density (ρ‾) significantly affected the U-value. The study also demonstrated that polymer lattice structures can be designed to select the optimal lattice configuration. Varying lattice topology had a notable impact on compression strength. It can be concluded that triangular and diamond lattice specimens with ρ‾=40% outperformed other lattice topologies due to their superior mechanical properties, the flexibility of additive manufacturing, and faster manufacturing time. The design of diverse lattice topologies holds promise for incorporating porosity into rigid materials, achieving high thermal and mechanical performance for energy-saving applications.

In recent years, the use of three-dimensional printing to create construction components has advanced quickly; it is possible now to simplify construction, increase speed, and lower cost while using natural resources responsibly. It also allows us to use recycled material to produce building envelopes while increasing design flexibility. However, the thermal performance of building materials must be characterized to achieve the necessary energy efficiency of the building envelopes. This study aims to develop, produce, and calibrate a hot box calorimeter at a reasonable price for thermal testing components building envelope. The heat loss through these components using a hot box can be measured in a lab to get an idea of the thermal performance of the building envelopes. In order to evaluate and analyze the thermal performance of various 3D-printed building brick samples made in the labs, this study explains the design and creation of an inexpensive hot box. The hot box can conduct a conventional thermal experiment, which involves monitoring heat flux, surface temperatures, and air temperatures. The testing process, instrumentation, test conditions, and validation of the new metering box are all covered in the article. The U-value of the brand-new lattice-based 3D printed building blocks was afterward determined using the validated new hot box. It was observed that the U-values values of 1.04 W/m2.K and 0.99 W/m2.K, respectively, for small components utilizing developed hot box and larger lattice panels using commercial equipment, with a maximum variance of 5%. It highlights the dependability of the hot box apparatus, which is also made affordable to operate by using less material for specimen preparation and less energy to maintain the temperature in the hot and cold chambers. Its small size also makes setup and thermal testing of construction materials simple.

Abstract Background To develop evidence-based clinical practice guidelines on venous thromboembolism (VTE) prevention in adults with trauma in inpatient settings. Methods The Saudi Critical Care Society (SCCS) sponsored guidelines development and included 22 multidisciplinary panel members who completed conflict-of-interest forms. The panel developed and answered structured guidelines questions. For each question, the literature was searched for relevant studies. To summarize treatment effects, meta-analyses were conducted or updated. Quality of evidence was assessed using the Grading Recommendations, Assessment, Development, and Evaluation (GRADE) approach, then the evidence-to-decision (EtD) framework was used to generate recommendations. Recommendations covered the following prioritized domains: timing of pharmacologic VTE prophylaxis initiation in non-operative blunt solid organ injuries; isolated blunt traumatic brain injury (TBI); isolated blunt spine trauma or fracture and/or spinal cord injury (SCI); type and dose of pharmacologic VTE prophylaxis; mechanical VTE prophylaxis; routine duplex ultrasonography (US) surveillance; and inferior vena cava filters (IVCFs). Results The panel issued 12 clinical practice recommendations—one, a strong recommendation, 10 weak, and one with no recommendation due to insufficient evidence. The panel suggests starting early pharmacologic VTE prophylaxis for non-operative blunt solid organ injuries, isolated blunt TBIs, and SCIs. The panel suggests using low molecular weight heparin (LMWH) over unfractionated heparin (UFH) and suggests either intermediate–high dose LMWH or conventional dosing LMWH. For adults with trauma who are not pharmacologic candidates, the panel strongly recommends using mechanical VTE prophylaxis with intermittent pneumatic compression (IPC). The panel suggests using either combined VTE prophylaxis with mechanical and pharmacologic methods or pharmacologic VTE prophylaxis alone. Additionally, the panel suggests routine bilateral lower extremity US in adults with trauma with elevated risk of VTE who are ineligible for pharmacologic VTE prophylaxis and suggests against the routine placement of prophylactic IVCFs. Because of insufficient evidence, the panel did not issue any recommendation on the use of early pharmacologic VTE prophylaxis in adults with isolated blunt TBI requiring neurosurgical intervention. Conclusion The SCCS guidelines for VTE prevention in adults with trauma were based on the best available evidence and identified areas for further research. The framework may facilitate adaptation of recommendations by national/international guideline policymakers.

Accurate modeling of nonbonded interactions between protein kinases and their small molecule inhibitors is essential for structure-based drug design. Quantum chemical methods such as density functional theory (DFT) hold significant promise for quantifying the strengths of these key protein–ligand interactions. However, the accuracy of DFT methods can vary substantially depending on the choice of exchange–correlation functionals and associated basis sets. In this study, a comprehensive benchmarking of nine widely used DFT methods was carried out to identify an optimal approach for quantitative modeling of nonbonded interactions, balancing both accuracy and computational efficiency. From a database of 2139 kinase-inhibitor crystal structures, a diverse library of 49 nonbonded interaction motifs was extracted, encompassing CH–π, π–π stacking, cation–π, hydrogen bonding, and salt bridge interactions. The strengths of nonbonded interaction energies for all 49 motifs were calculated at the advanced CCSD(T)/CBS level of theory, which serve as references for a systematic benchmarking of BLYP, TPSS, B97, ωB97X, B3LYP, M062X, PW6B95, B2PLYP, and PWPB95 functionals with D3BJ dispersion correction alongside def2-SVP, def2-TZVP, and def2-QZVP basis sets. The RI, RIJK, and RIJCOSX approximations were used for selected functionals. It was found that the B3LYP/def2-TZVP and RIJK RI-B2PLYP/def2-QZVP methods delivered the best combination of accuracy and computational efficiency, making them well-suited for efficient modeling of nonbonded interactions responsible for molecular recognition of protein kinase inhibitors in their targets.

This paper explores the potential of rooftop solar PV to meet the electricity demand in the urban areas of Abha city, Saudi Arabia (KSA), minimising imports from the grid. A localised energy system for Abha is proposed that considers two types of loads: (i) residential loads with a monthly aggregated energy consumption of 172,440 MWh and an electric demand of 239.5 MW, and (ii) commercial loads with a monthly aggregated energy consumption of 179,280 MWh and an electric demand of 249 MW. The grid currently supplies this load. This paper proposes a PV development planning tool for residential and commercial areas to calculate the total PV production for each type of load to achieve a balanced energy area, considering (i) the number of buildings, (ii) the type of load, (iii) the peak load, and (iv) the total PV array area in m2 per building. The results of the modelling study using real data demonstrate that the anticipated total PV production in residential and commercial areas is sufficient to meet local peak demand, and there is an excess of power that can either be stored locally or exported to the grid.

Objectives: There is local and regional deficiency in the data examining the contribution of resistant pathogens to device-associated healthcare-associated infections (DA-HAIs). The objective was to examine such data in a multi-hospital system in Saudi Arabia in comparison with the US National Health Surveillance Network (NHSN). Methods: Surveillance of DA-HAIs was prospectively conducted between 2008 and 2016 in four hospitals of Ministry of National Guard Health Affairs. Consecutive NHSN reports were used for comparisons. Definitions and methodology of DA-HAIs and bacterial resistance were based on NHSN. Results: A total 1260 pathogens causing 1141 DA-HAI events were included. Gram negative pathogens (GNPs) were responsible for 62.5% of DA-HAIs, with a significantly higher Klebsiella, Pseudomonas, Acinetobacter, and Enterobacter than NHSN hospitals. Approximately 28.3% of GNPs and 23.5% of gram positive pathogens (GPPs) had some type of resistance. Nearly 34.3% of Klebsiella were resistant to third/fourth generation cephalosporins, 4.8% of Enterobacteriaceae were carbapenem-resistant (CRE), 24.4% of Staphylococcus aureus were methicillin-resistant (MRSA), and 21.9% of Enterococci were vancomycin-resistant (VRE). Multidrug resistance (MDR) was 65.0% in Acinetobacter, 26.4% in Escherichia coli, 23.0% in Klebsiella, and 14.9% in Pseudomonas. Resistant GNPs including cephalosporin-resistant Klebsiella, MDR Klebsiella, and MDR Escherichia coli were significantly more frequent while resistant GPPs including MRSA and VRE were significantly less frequent than NHSN hospitals. Conclusion: The current findings showed heavier and more resistant contribution of GNPs to DA-HAIs in Saudi hospitals compared with American hospitals. The higher resistance rates in Klebsiella and Escherichia coli are alarming and call for effective antimicrobial stewardship programs.

Abstract Background Studying temporal changes in resistant pathogens causing healthcare-associated infections (HAIs) is crucial in improving local antimicrobial and infection control practices. The objective was to describe ten-year trends of resistance in pathogens causing HAIs in a tertiary care setting in Saudi Arabia and to compare such trends with those of US National Health Surveillance Network (NHSN). Methods Pooled analysis of surveillance data that were prospectively collected between 2007 and 2016 in four hospitals of Ministry of National Guard Health Affairs. Definitions and methodology of HAIs and antimicrobial resistance were based on NHSN. Consecutive NHSN reports were used for comparisons. Results A total 1544 pathogens causing 1531 HAI events were included. Gram negative pathogens (GNP) were responsible for 63% of HAIs, with a significant increasing trend in Klebsiella spp. and a decreasing trend in Acinetobacter. Methicillin-resistant Staphylococcus aureus (27.0%) was consistently less frequent than NHSN. Vancomycin-resistant Enterococci (VRE, 20.3%) were more than doubled during the study, closing the gap with NHSN. Carbapenem resistance was highest with Acinetobacter (68.3%) and Pseudomonas (36.8%). Increasing trends of carbapenem resistance were highest in Pseudomonas and Enterobacteriaceae, closing initial gaps with NHSN. With the exception of Klebsiella and Enterobacter, multidrug-resistant (MDR) GNPs were generally decreasing, mainly due to the decreasing resistance towards cephalosporins, fluoroquinolones, and aminoglycosides. Conclusion The findings showed increasing trends of carbapenem resistance and VRE, which may reflect heavy use of carbapenems and vancomycin. These findings may highlight the need for effective antimicrobial stewardship programs, including monitoring and feedback on antimicrobial use and resistance.

Dosage adjustment of meropenem is usually recommended in hemodialysis (HD) patients and about 30% of meropenem is cleared during regular HD sessions. However, most of the published trials excluded patients on regular HD. Little is known about the accurate dosage of meropenem needed to avoid central nervous system toxicity. Herein, we report a 65-year-old Saudi female, a known case of end-stage renal disease on regular HD, who was admitted because of pyelonephritis and started on meropenem in the recommended dose according to cultures and sensitivity. She developed tonic-clonic convulsions after the 7th dose. Seizures were completely aborted after discontinuation of the offending drug. The recommended dosage of 500 mg daily in HD patients may still be too high particularly in Asian patients owing to their relatively small body mass index.

BACKGROUND: Deep venous thrombosis causes morbidity and mortality for hospitalized patients. There are several risk factors for developing deep venous thrombosis including trauma, immobilization, and surgery. Complications of deep venous thrombosis result from the delay in diagnosis and treatment, so prophylaxis is the perfect option to avoid these serious complications, especially for those at risk. AIM: The aim of this is to investigate the impact of DVT protocol on thromboprophylaxis in minimizing the disease burden of under-recognized and preventable pathology. MATERIALS AND METHODS: This is a retrospective descriptive study which used DVT protocol through the Knowledge Translation Committee (KTC). RESULTS: Suboptimal prophylaxis decreased from 47% in 2011 to 6% in 2017, whereas appropriate prophylaxis increased among patients from 45% in 2011 to 89% in 2017. CONCLUSION: There was an increase in offering DVT prophylaxis for hospitalized medical patients as a result of the implementation of DVT protocol through KTC.

Summary: Tick-borne flaviviruses (TBFVs) can cause life-threatening encephalitis and hemorrhagic fever. To identify virus-host interactions that may be exploited as therapeutic targets, we analyzed the TBFV polyprotein in silico for antiviral protein-binding motifs. We obtained two putative tumor necrosis factor receptor-associated factor 6 (TRAF6)-binding motifs (TBMs) within the protease domain of the viral nonstructural 3 (NS3) protein. Here, we show that TBFV NS3 interacted with TRAF6 during infection and that TRAF6 supports TBFV replication. The proviral role of TRAF6 was not seen with mosquito-borne flaviviruses, consistent with the lack of conserved TBMs. Mutation of the second TBM within NS3 disrupted TRAF6 binding, coincident with reduced abundance of mature, autocatalytically derived form of the NS3 protease and significant virus attenuation in vitro. Our studies reveal insights into how flaviviruses exploit innate immunity for the purpose of viral replication and identify a potential target for therapeutic design. : Molecular Interaction; Microbiology; Viral Microbiology Subject Areas: Molecular Interaction, Microbiology, Viral Microbiology

Objectives: Implant therapy has gained wide popularity in the recent years. A complete information on implant therapy should be provided to patient by the dentist. The aim of present study is to evaluate the knowledge, attitude, source of information and acceptance of dental implants among the general population in the Southern region of Saudi Arabia.Methods: A total of 712 patients were randomly selected from the OPD of dental hospitals across the southern region of Saudi Arabia. The designed questionnaire comprised of 15 open-ended questions. Only Saudi national population was selected for the survey. The questionnaire was divided into demographic data, knowledge, attitude and participant’s acceptance towards implant therapy. The collected data were statistically analyzed using the Statistical Package for Social Sciences.Results: Out of 712 participants, 675 complete the survey. 59.1% were male and 41.9% were females with an average age of 39.6 years old. All variables except for age showed statistically significant difference in the knowledge about implant among the study groups (p

BACKGROUND: Many studies have shown that open and laparoscopicsurgery for resection of colonic cancers produce similar short- and long-term results, but no data have been reported from Saudi Arabia. OBJECTIVE: Compare 3-year disease-free and overall survival after laparoscopic versus open curative resection for potentially curable colon cancer. DESIGN: Multicenter retrospective cohort study. SETTING: Tertiary academic hospital. PATIENTS AND METHODS: We analyzed data of patients who underwent curative resection for potentially curable colon cancer using the laparoscopic or open approach at three tertiary care centers during the period 2000-2015. MAIN OUTCOME MEASURES: Overall and disease-free 3-year survival were the primary endpoints. Secondary endpoints included conversion rate, duration of surgery, length of hospital stay, rate of wound infection, resumption of bowel function, number of lymph nodes retrieved, adequacy of resection and rate of recurrence. Risk factors for recurrence, including complete mesocolic excision, were assessed. SAMPLE SIZE: 721. RESULTS: Patient and tumor characteristics were similar in the two groups except for ASA class (P

Objective: To assess the preparedness for handling injuries by female primary school teachers based on their knowledge, attitude, practice and their willingness to learn first aid. Methods: A cross-sectional questionnaire on first aid was provided to female primary school teachers, and the knowledge, attitude, practice and their willingness to learn first aid were investigated. Data were analyzed using SPSS version 23. Quantitative data were analyzed by one-way ANOVA, categorical variables were analyzed by the Chi-square test. The level of significance was set at P

Background. Basic life support (BLS) is a level of medical care that is used for individuals with life-threatening illnesses or injuries until they can be given full medical care at a hospital. It can be provided by trained medical personnel, including emergency medical technicians and paramedics, and by qualified bystanders. Vital areas of adult BLS include immediate identification of sudden cardiac arrest and activation of the emergency response system, early performance of high-quality cardiopulmonary resuscitation (CPR), and rapid defibrillation, when appropriate. Aim. To assess the awareness of secondary school students regarding BLS in Abha City, Saudi Arabia. Methodology. A descriptive cross-sectional survey was conducted targeting all accessible secondary school students in Abha City during the academic years 2018-2019. After explaining the objectives and importance of the research topic, all students in the three grades were invited to complete the study questionnaire. The questionnaire was developed by the researchers after reviewing the literature for related topics and consulting an expert for any additions or modifications. Results. The study included 761 students with ages ranging from 15 to 20 years and a mean age of 17 ± 1 years old. Male students accounted for 53.6% of the participants, and 96.7% of the participants were Saudi. Exactly 31% of the students had had a BLS training course, among which 79.2% had had training that lasted for only one day. Regarding awareness, 65% of the students had heard about BLS, and 44% knew about CPR. Exactly 52% of the students indicated that they should call the ER if there was a case with fainting. A total of 45.3% of the students reported that airway checking was the first step in CPR, and 16.7% reported that the chest compression to oral breathing ratio should be 30 to 2. Conclusions and Recommendations. In conclusion, the study revealed that poor awareness regarding BLS was present among the students. The researchers concluded that less than one-third of the students had BLS training. BLS should be taught, theoretically and practically (with simulations), to middle and high school students as BLS involves relatively simple concepts and methods.

Bacterial infection and its resistance is a major health issue that affects millions of people throughout the world. There is always a need to search forth new and safest drug from natural resources to fight these challenges. Sesame seed essential oil is a rich source of protein with high medicinal value since the ancient time peoples are using for several remedies in Saudi Arabia.Therefore, the current study is aimed to discover the potential activity of the locally available sesame oil for antibacterial action based on ethnobotanical knowledge and traditional utilization as a therapeutic agent to treat several kinds of health problem in Saudi culture. Gas chromatography / mass spectrometry (GC/MS) analysis of sesame essential oil extracted from locally available sesame seeds represented 39 different chemical compounds. Sesamin and sesamol were the principal components alongwith fatty acids and triglycerides. Results indicated that the locally available sesame oil was found rich in sesamin contents (24.45%). The spectrum of antibacterial effect of sesame seed essential oil was exhibited significantly against Escherichia coli followed by Staphylococcus aureus, Streptococcus pyogenes, Klebsiella pneumoniae and Pseudomonas aeruginosa respectively. The results indicate that sesame oil was found most effective against three bacteria i.e. E. coli, S. aureus and S. pyogenes.

BackgroundWestern dietary habits, coupled with a sedentary lifestyle, are potential contributors to the prevalence and rapid increase in the incidence of obesity in Saudi Arabia. This study aimed to investigate the association between students' weight status and their eating behaviors and practices. Another aim was to assess students' awareness of the health risks associated with obesity.MethodsA cross-sectional survey was conducted among a sample of 416 (53% male and 47% female) undergraduate students, aged 18-26 years old, between January 6 and April 6, 2019, from colleges of Health Sciences at Jazan University in the Kingdom of Saudi Arabia (K.S.A). Students completed a self-administered questionnaire and recorded their measured anthropometric parameters.ResultsThe prevalence of overweight (20.4%) and obesity (14.9%) were relatively high among the participants. There were statistically significant associations between Body Mass Index (BMI) and the different settings of food consumption (i.e., dining on a table (or) in the Islamic way: squatting on the ground) (pConclusionThe prevalence of obesity and overweight were reasonably high in our study sample and were affected by several factors related to students' eating behaviors and practices. This warrants the need for rigorous and frequent health education interventions on healthy eating behaviors, dietary practices, with an emphasis on the importance of adopting an active, healthy lifestyle.

Protein kinases are key enzymes in many signal transduction pathways, and play a crucial role in cellular proliferation, differentiation, and various cell regulatory processes. However, aberrant function of kinases has been associated with cancers and many other diseases. Consequently, competitive inhibition of the ATP binding site of protein kinases has emerged as an effective means of curing these diseases. Over the past three decades, thousands of protein kinase inhibitors (PKIs) with varying molecular frames have been developed. Large-scale data mining of the Protein Data Bank resulted in a database of 2139 non-redundant high-resolution X-ray crystal structures of PKIs bound to protein kinases. This provided us with a unique opportunity to study molecular determinants for the molecular recognition of PKIs. A chemoinformatic analysis of 2139 PKIs resulted in findings that PKIs are “flat” molecules with high aromatic ring counts and low fractions of sp3 carbon. All but one PKI possessed one or more aromatic rings. More importantly, it was found that the average weighted hydrogen bond count is inversely proportional to the number of aromatic rings. Based on this linear relationship, we put forward the exchange rule of hydrogen bonding interactions and non-bonded π-interactions. Specifically, a loss of binding affinity caused by a decrease in hydrogen bonding interactions is compensated by a gain in binding affinity acquired by an increase in aromatic ring-originated non-bonded interactions (i.e., π–π stacking interactions, CH–π interactions, cation–π interactions, etc.), and vice versa. The very existence of this inverse relationship strongly suggests that both hydrogen bonding and aromatic ring-originated non-bonded interactions are responsible for the molecular recognition of PKIs. As an illustration, two representative PKI–kinase complexes were employed to examine the relative importance of different modes of non-bonded interactions for the molecular recognition of PKIs. For this purpose, two FDA-approved PKI drugs, ibrutinib and lenvatinib, were chosen. The binding pockets of both PKIs were thoroughly examined to identify all non-bonded intermolecular interactions. Subsequently, the strengths of interaction energies between ibrutinib and its interacting residues in tyrosine kinase BTK were quantified by means of the double hybrid DFT method B2PLYP. The resulting energetics for the binding of ibrutinib in tyrosine kinase BTK showed that CH–π interactions and π–π stacking interactions between aromatic rings of the drug and hydrophobic residues in its binding pocket dominate the binding interactions. Thus, this work establishes that, in addition to hydrogen bonding, aromatic rings function as important molecular determinants for the molecular recognition of PKIs. In conclusion, our findings support the following pharmacophore model for ATP-competitive kinase inhibitors: a small molecule features a scaffold of one or more aromatic rings which is linked with one or more hydrophilic functional groups. The former has the structural role of acting as a scaffold and the functional role of participating in aromatic ring-originated non-bonded interactions with multiple hydrophobic regions in the ATP binding pocket of kinases. The latter ensure water solubility and form hydrogen bonds with the hinge region and other hydrophilic residues of the ATP binding pocket.

Poly(ethylene-co-vinylalcohol) (E-VOH) and carbon nanotube-filled poly (vinyl alcohol-co-ethylene) (E-VOH/CNT) were used as membranes to separate benzene/cyclohexane mixtures by pervaporation technique. To reach this goal, E-VOH and E-VOH/CNT membranes were prepared by solvent casting method and characterized by differential scanning calorimetry (DSC), thermogravimetry analysis (TGA), X-ray diffraction (XRD), and scanning electron microscopy (SEM). The swelling tests were used to study the mass transfer of the benzene/cyclohexane mixture and their pure components. The separation by pervaporation process was carried out at 25 °C in which the effect of CNTs incorporated into E-VOH matrix and the initial concentration of benzene in the feed on the permeate flux, j, and separation factor, β, performance was investigated. The results obtained were very promising, in which the integration of CNTs through E-VOH chains increased the absorption area and raised the flux to 740 g/m2∙h. The separation factor increased to 9.03 and the pervaporation separation reached an index of 5942.2 g/m2∙h for the azeotropic mixture during 3 h of the separation process. In contrast, for the unfilled E-VOH membrane, it was found that these parameters were a rise of 280 g∙m−2∙h−1, separation factor of 12.90 and pervaporation separation index of 3332.0 g/m2∙h, under the same conditions. Likewise, the calculation of the performance of the E-VOH/CNT membrane with regard to that of the unfilled membrane indicated 2.64 for the total flux and 0.70 for the separation factor. It was also revealed that the best compromise of the filled membrane in terms of total cumulative flux and separation factor is obtained for the feed containing the azeotropic mixture.

Background. Mucocele of the appendix is a rare condition, the pathological classification and management strategy of which have not been standardized yet. Aim. To report on our management of appendiceal mucocele, highlighting the pitfalls and possible means for avoiding them. Materials and Methods. Our registries were reviewed to retrieve cases of appendiceal mucocele, encountered in the period from July 2008 to May 2013. Results. We had 9 cases, three males and sex females, with a median age of 62 years. Abdominal ultrasound (US) and computerized axial tomography scan (CT) suspected the diagnosis in only one case each. Open appendectomy was done in two cases of mucinous cystadenoma with no further surgery performed, despite the positive margin in one. Laparoscopic appendectomy was done in three cases: mucinous cystadenoma in one case which needed no further surgery, mucinous cystadenocarcinoma with pseudomyxoma peritonei in another, and low grade mucinous tumour in a third case, and all needed subsequent right hemicolectomy. Exploratory laparotomy was done in three cases: of these, synchronous right hemicolectomy was done in one case of mucinous cystadenoma/?mucinous tumour of uncertain malignant potential; in the other two cases, appendectomy only was done for mucinous hyperplasia with carcinoid tumour of the appendix in one case and mucinous cystadenoma/?mucinous tumour of uncertain malignant potential in another. The 9th case was discovered upon laparoscopy for cholecystectomy; when pseudomyxoma peritonei arising from an appendiceal mucocele was found, laparoscopic appendectomy with peritoneal biopsy was then performed instead. Histopathologic diagnostic uncertainty was present in two cases of mucinous cystadenoma where mucinous tumour of uncertain malignant potential was an alternative possibility. Perioperative colonoscopy was performed in only one case and our follow-up programme was defective, with the longest period being 180 days. Conclusion. Mucocele of the appendix should be considered in the differential diagnosis of cystic lesions in the right lower abdomen. Owing to its rarity, it continues to intrigue the surgeon as well as the radiologist and pathologist alike. For mucinous cystadenocarcinoma, right hemicolectomy is usually needed, whereas for hyperplasia and cystadenoma, appendectomy usually suffices if the resection margins are free. For mucinous tumours of uncertain malignant potential and low grade mucinous tumours as well as pseudomyxoma peritonei, the decision is not as simple. As for laparoscopic surgery, no solid proof exists with or against its safety. Although not yet standardized, perioperative colonoscopy and regular follow-up to detect early recurrences should probably be part of the management plan.

Study Design: Cross sectional Background: Computer vision syndrome (CVS) is defined as a collection of vision-related symptoms and musculoskeletal symptoms that happen due to continuous and improper use of electronic devices, such as computers, tablets, and smart phones. It causes eye problems and muscular complaints, which may lead to a decreased efficiency and quality of life. The aim of this study is to estimates the prevalence, knowledge, and associated factors of CVS among electronic device users in the Asser region, Kingdom of Saudi Arabia. Methods: A Descriptive cross-sectional study was conducted to All Saudi and non-Saudi population of Aseer region except People who can’t read or understand Arabic. The sample size required for this study is calculated as 700 participants for 95% confidence level and a margin of error of 5%. The participants received electronic self-administered questionnaire distributed via social media platforms during 2022. The tool covers the following three parts: bio demographic data, knowledge and associated factors related questions and prevalence of the CVS symptoms. Informed consent will be obtained from all participants. Furthermore, the questionnaire is anonymous. Results: A total of 700 participants who met the inclusion criteria completed the study questionnaire. The age of the responders varied from less than 20 years to older than 60 years. A total of 367 (53.71%) responses were females. Eye problems after the use of electronic devices were experienced by 393 (56.14%) of the responders. Neck and shoulder pain being the most common symptom (79.95%), followed by blurred vision (71.07%), burning eye sensation (61.68%) and headache (60.41%). The more spent time with less taking breaks on electronic devices increasing the incidence of CVS symptoms. Back bent position was correlate with CVS symptoms . Conclusion: Computer vision syndrome (CVS) is very common among the study participants, with neck and shoulder pain being the most common symptoms. This study has shown that the development of CVS is associated significantly with the longer duration of electronic devices use(more than 5 hours daily), no taking breaks while using electronic devices, short distance (less than 40cm)from the electronic devices and sitting with back bent. We found in our study that the computer vision syndrome (CVS) is a growing public health problem, resulting in variety of complaints and symptoms. Thus, preventive measures and community education about the burden of such lifestyle, and the proper handling of devices must be addressed. [ABSTRACT FROM AUTHOR]