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16 results on '"Saad Albichr, Imane"'

5. Cellular response to COVID-19 vaccines in hematologic malignancies patients: a new hope for non-responders?

Author

UCL - SSS/DDUV - Institut de Duve, UCL - SSS/DDUV/BCHM - Biochimie-Recherche métabolique, UCL - SSS/DDUV/SIGN - Cell signalling, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de médecine interne générale, UCL - (SLuc) Service de biochimie médicale, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Service d'hématologie, Saad Albichr, Imane, De Greef, Julien, Van Den Neste, Eric, Poire, Xavier, Havelange, Violaine, Vekemans, Marie-Christiane, Bailly, Sarah, Yombi, Jean Cyr, Mzougui, Samy, Scohy, Anaïs, Kabamba-Mukadi, Benoît, UCL - SSS/DDUV - Institut de Duve, UCL - SSS/DDUV/BCHM - Biochimie-Recherche métabolique, UCL - SSS/DDUV/SIGN - Cell signalling, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de médecine interne générale, UCL - (SLuc) Service de biochimie médicale, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Service d'hématologie, Saad Albichr, Imane, De Greef, Julien, Van Den Neste, Eric, Poire, Xavier, Havelange, Violaine, Vekemans, Marie-Christiane, Bailly, Sarah, Yombi, Jean Cyr, Mzougui, Samy, Scohy, Anaïs, and Kabamba-Mukadi, Benoît

Abstract

SARS-CoV-2 vaccines offered great hope in controlling the worldwide COVID-19 pandemic. At present, SARS-CoV-2 vaccines have shown excellent efficacy to prevent COVID-19 but immunocompromised patients were left-off most vaccine clinical trials albeit their extreme vulnerability. Indeed, immunosuppression is associated with a higher risk of developing severe COVID-19 with mortality rates over 30% reported in patients with hematologic malignancies (HM). [...]

Published
2022

6. Delayed Humoral Response After 2 Doses of the BNT162b2 Vaccine in a Belgian Kidney Transplant Cohort.

Author

UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (MGD) Service de néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - (SLuc) Service de microbiologie, UCL - SSS/DDUV - Institut de Duve, UCL - (SLuc) Département de médecine interne et services associés, Georgery, Hélène, Devresse, Arnaud, Saad Albichr, Imane, Lucas, Sophie, Yombi, Jean Cyr, Belkhir, Leïla, De Greef, Julien, Scohy, Anaïs, Kabamba Mukadi, Benoît, Goffin, Eric, Kanaan, Nada, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (MGD) Service de néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - (SLuc) Service de microbiologie, UCL - SSS/DDUV - Institut de Duve, UCL - (SLuc) Département de médecine interne et services associés, Georgery, Hélène, Devresse, Arnaud, Saad Albichr, Imane, Lucas, Sophie, Yombi, Jean Cyr, Belkhir, Leïla, De Greef, Julien, Scohy, Anaïs, Kabamba Mukadi, Benoît, Goffin, Eric, and Kanaan, Nada

Published
2022

7. Cellular response to COVID-19 vaccines in hematologic malignancies patients: a new hope for non-responders?

Author

Saad Albichr, Imane, primary, De Greef, Julien, additional, Van Den Neste, Eric, additional, Poiré, Xavier, additional, Havelange, Violaine, additional, Vekemans, Marie-Christiane, additional, Bailly, Sarah, additional, Yombi, Jean-Cyr, additional, Mzougui, Samy, additional, Scohy, Anaïs, additional, and Kabamba-Mukadi, Benoît, additional

Published
2021
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9. T cell and Antibody Response after two Doses of the BNT162b2 Vaccine in a Belgian Cohort of Kidney Transplant Recipients

Author

Devresse, Arnaud, Saad Albichr, Imane, Georgery, Hélène, Yombi, Jean Cyr, De Greef, Julien, Belkhir, Leïla, Mzougui, Samy, Scohy, Anaïs, Darius, Tom, Buemi, Antoine, Goffin, Eric, Kabamba-Mukadi, Benoît, Kanaan, Nada, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, and UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology

Subjects
Transplantation
Published
2021

10. Better late than never: eventual seroconversion against SARS-CoV-2 in a kidney transplant recipient after repeated immune challenge and monoclonal antibody therapy.

Author

UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, De Greef, Julien, Devresse, Arnaud, Saad Albichr, Imane, Scohy, Anais, Kanaan, Nada, Georgery, Hélène, Belkhir, Leila, Kabamba, Benoit, Yombi, Jean Cyr, Goffin, Eric, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, De Greef, Julien, Devresse, Arnaud, Saad Albichr, Imane, Scohy, Anais, Kanaan, Nada, Georgery, Hélène, Belkhir, Leila, Kabamba, Benoit, Yombi, Jean Cyr, and Goffin, Eric

Published
2021

11. T cell and Antibody Response after two Doses of the BNT162b2 Vaccine in a Belgian Cohort of Kidney Transplant Recipients

Author

UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, Devresse, Arnaud, Saad Albichr, Imane, Georgery, Hélène, Yombi, Jean Cyr, De Greef, Julien, Belkhir, Leïla, Mzougui, Samy, Scohy, Anaïs, Darius, Tom, Buemi, Antoine, Goffin, Eric, Kabamba-Mukadi, Benoît, Kanaan, Nada, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, Devresse, Arnaud, Saad Albichr, Imane, Georgery, Hélène, Yombi, Jean Cyr, De Greef, Julien, Belkhir, Leïla, Mzougui, Samy, Scohy, Anaïs, Darius, Tom, Buemi, Antoine, Goffin, Eric, Kabamba-Mukadi, Benoît, and Kanaan, Nada

Published
2021

12. Better Late than Never: Eventual Seroconversion against SARS-CoV-2 in a Kidney Transplant Recipient after Repeated Immune Challenge and Monoclonal Antibody Therapy.

Author

UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Service de médecine interne générale, UCL - (SLuc) Service d'hématologie, UCL - (SLuc) Service de néphrologie, De Greef, Julien, Devresse, Arnaud, Saad Albichr, Imane, Scohy, Anaïs, Kanaan, Nada, Georgery, Hélène, Belkhir, Leïla, Kabamba-Mukadi, Benoît, Yombi, Jean Cyr, Goffin, Eric, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Service de médecine interne générale, UCL - (SLuc) Service d'hématologie, UCL - (SLuc) Service de néphrologie, De Greef, Julien, Devresse, Arnaud, Saad Albichr, Imane, Scohy, Anaïs, Kanaan, Nada, Georgery, Hélène, Belkhir, Leïla, Kabamba-Mukadi, Benoît, Yombi, Jean Cyr, and Goffin, Eric

Abstract

To the editor: Kidney transplant recipients are disproportionately affected by coronavirus disease 2019 (COVID-19). In addition to limited therapeutic options, concerns have arisen regarding poor vaccine efficacy in this population.[...]

Published
2021

13. Evaluation of the automated BD Phoenix CPO Detect test for detection and classification of carbapenemases in Gram negatives.

Author

UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, UCL - SSS/LDRI - Louvain Drug Research Institute, Saad Albichr, Imane, Anantharajah, Ahalieyah, Dodémont, Magali, Hallin, Marie, Verroken, Alexia, Rodriguez-Villalobos, Hector, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, UCL - SSS/LDRI - Louvain Drug Research Institute, Saad Albichr, Imane, Anantharajah, Ahalieyah, Dodémont, Magali, Hallin, Marie, Verroken, Alexia, and Rodriguez-Villalobos, Hector

Abstract

We evaluated the performance of the automated BD Phoenix CPO Detect test (BD-CPO test) for detection and Ambler classification of carbapenemases in Enterobacteriaceae, P.aeruginosa and A.baumannii complex. A collection of 287 Gram-negative clinical isolates, with a reduced susceptibility to at least one carbapenem including 184 carbapenemase-producing organisms (CPO) and 103 non-CPO, was tested. The BD-CPO test showed an overall sensitivity of 89.7% and specificity of 83.5% for carbapenemase detection. 1/7 of class A, 82.9% of class B, and 89.8% of class D carbapenemases were correctly classified. Poor detection sensitivity of 68.9% and specificity of 62.1% in P.aeruginosa was observed. However, combination with ceftazidime/avibactam susceptibility, provided by this panel, increased the performances for P.aeruginosa. The integration of an automated carbapenemase detection and classification in routine susceptibility panels would save time and help for therapeutic management. Further developments are needed to improve the accuracy of the BD-CPO test.

Published
2020

14. Cellular response to COVID-19 vaccines in hematologic malignancies patients: a new hope for non-responders?

Author

Saad Albichr, Imane, De Greef, Julien, Van Den Neste, Eric, Poiré, Xavier, Havelange, Violaine, Vekemans, Marie-Christiane, Bailly, Sarah, Yombi, Jean-Cyr, Mzougui, Samy, Scohy, Anaïs, and Kabamba-Mukadi, Benoît

Subjects
*HUMORAL immunity, *SEROCONVERSION, *COVID-19 vaccines, *HEMATOLOGIC malignancies, *VACCINE effectiveness, *CORONAVIRUS diseases
Abstract

At present, SARS-CoV-2 vaccines have shown excellent efficacy to prevent COVID-19 but immunocompromised patients were left-off most vaccine clinical trials albeit their extreme vulnerability [[1]]. Several studies showed that patients with HM, particularly lymphoid malignancies, had a lower antibody response to COVID-19 vaccines than general population and might be left unprotected from SARS-CoV-2 infection [[3], [5]]. Keywords: COVID-19; SARS-CoV-2; vaccine; cellular immunity; hematologic malignancies EN COVID-19 SARS-CoV-2 vaccine cellular immunity hematologic malignancies 743 746 4 03/07/22 20220301 NES 220301 SARS-CoV-2 vaccines offered great hope in controlling the worldwide COVID-19 pandemic. At initiation of vaccination against COVID-19, 10 patients were receiving ibrutinib, 5 patients were receiving anti-CD20 treatments (4 rituximab and 1 obinutuzumab), including 3 patients receiving a combination of ibrutinib and rituximab. [Extracted from the article]

Published
2022
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