32 results on '"SY"'
Search Results
2. Quantify soil erosion and sediment export in response to land use/cover change in the Suha watershed, northwestern highlands of Ethiopia: implications for watershed management
- Author
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Nigussie Yeneneh, Eyasu Elias, and Gudina Legese Feyisa
- Subjects
LULC change ,GIS ,RUSLE ,Soil erosion ,SY ,Suha watershed ,Environmental technology. Sanitary engineering ,TD1-1066 ,Environmental sciences ,GE1-350 - Abstract
Abstract Soil erosion accelerated by human activities is a critical challenge affecting soil health, agricultural productivity, food security and environmental sustainability in the highlands of Ethiopia. The aim of this study was to examine the dynamics of soil loss and sediment yield potential, and identify soil erosion hotspots using RUSLE with GIS in the Suha watershed, north western highlands of Ethiopia. Digital Elevation Model, LU/LC, rainfall, soil, and conservation practice were used as input data for RUSLE model. The estimated total annual soil loss for the entire watershed increased from 1.22 million tons in 1985 to 2.43 million tons in 2019, with average annual soil loss rates of 15.2 t ha−1 yr−1 and 31.4 t ha−1 yr−1 respectively. Total sediment yield also increased from 317.52 to 630.85 thousand tons over the past 35 years. In addition, the area of soil erosion hotspots changed from 15.2% (12,708 ha) to 32% (25,660 ha) during the same periods. Sub watershed 1, 2, 15, 17, 18, and 23 are severely degraded parts of the watershed. Expansion of agriculture and bare land as the expenses of other land use types over the past 35 years could be the major causes of extensive soil erosion risk in the watershed. Besides its temporal variability, soil loss and sediment export also showed variation between land use/cover classes. The estimated results of soil loss and sediment yield as well as soil erosion hotspots revealed that the soil erosion risk is progressively increasing during the study periods. Unless action is taken and the current condition is reversed, it will critically threat the livelihoods of the community in the watershed. Generally, the results underscore urgent demand for integrated and effective watershed management strategies.
- Published
- 2022
- Full Text
- View/download PDF
3. Quantify soil erosion and sediment export in response to land use/cover change in the Suha watershed, northwestern highlands of Ethiopia: implications for watershed management.
- Author
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Yeneneh, Nigussie, Elias, Eyasu, and Feyisa, Gudina Legese
- Subjects
SOIL erosion ,WATERSHED management ,LAND use ,SEDIMENTS ,UPLANDS ,SOIL dynamics ,GEOLOGIC hot spots ,WATERSHEDS - Abstract
Soil erosion accelerated by human activities is a critical challenge affecting soil health, agricultural productivity, food security and environmental sustainability in the highlands of Ethiopia. The aim of this study was to examine the dynamics of soil loss and sediment yield potential, and identify soil erosion hotspots using RUSLE with GIS in the Suha watershed, north western highlands of Ethiopia. Digital Elevation Model, LU/LC, rainfall, soil, and conservation practice were used as input data for RUSLE model. The estimated total annual soil loss for the entire watershed increased from 1.22 million tons in 1985 to 2.43 million tons in 2019, with average annual soil loss rates of 15.2 t ha
−1 yr−1 and 31.4 t ha−1 yr−1 respectively. Total sediment yield also increased from 317.52 to 630.85 thousand tons over the past 35 years. In addition, the area of soil erosion hotspots changed from 15.2% (12,708 ha) to 32% (25,660 ha) during the same periods. Sub watershed 1, 2, 15, 17, 18, and 23 are severely degraded parts of the watershed. Expansion of agriculture and bare land as the expenses of other land use types over the past 35 years could be the major causes of extensive soil erosion risk in the watershed. Besides its temporal variability, soil loss and sediment export also showed variation between land use/cover classes. The estimated results of soil loss and sediment yield as well as soil erosion hotspots revealed that the soil erosion risk is progressively increasing during the study periods. Unless action is taken and the current condition is reversed, it will critically threat the livelihoods of the community in the watershed. Generally, the results underscore urgent demand for integrated and effective watershed management strategies. [ABSTRACT FROM AUTHOR]- Published
- 2022
- Full Text
- View/download PDF
4. The antidepressant‐like effects of Shen Yuan: Dependence on hippocampal BDNF–TrkB signaling activation in chronic social defeat depression‐like mice.
- Author
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Jiang, Ning, Huang, Hong, Wang, Haixia, Lv, Jingwei, Zeng, Guirong, Wang, Qiong, Bao, Yu, Chen, Ying, and Liu, Xin‐Min
- Abstract
The Shen Yuan prescription (SY) comprises Panax ginseng (GT) and Polygala tenuifolia (YT), elicited superior antidepressant activity compared with that of GT or YT alone. The aim of this paper is to elucidate the effects of SY treatment on chronic social defeat stress (CSDS)‐induced depression‐like symptoms and the related mechanism. Our results indicated that SY treatment reverses the depressive‐like behaviors induced by CSDS as measured by the social interaction test, sucrose preference test, forced swim test, and tail suspension test. SY decreased the serum levels of CORT and increased hippocampal neurotransmitters (5‐HT, DA, and NE) in CSDS mice. Meanwhile, SY upregulated the brain‐derived neurotrophic factor (BDNF) signaling pathway and reversed the decreased hippocampal neurogenesis caused by CSDS. In addition, we found that the TrkB antagonist K252a fully blocked the SY effects on behavioral improvement and eliminated the promoting effects of SY on hippocampal neurogenesis and BDNF–TrkB signaling (including the downstream ERK and Akt pathways) activation, thus further demonstrating that BDNF–TrkB signaling was necessary for the SY effects. In conclusion, our study showed that SY acted as an antidepressant in mice exhibiting CSDS‐induced depression‐like symptoms, and its effect was facilitated by promoting hippocampal neurogenesis and BDNF signaling pathway activation. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
5. The Antidepressant-Like Effects of Shen Yuan in a Chronic Unpredictable Mild Stress Rat Model
- Author
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Ning Jiang, Haixia Wang, Hong Huang, Jingwei Lv, Guirong Zeng, Qiong Wang, Yu Bao, Ying Chen, and Xinmin Liu
- Subjects
SY ,depression ,CUMS ,neurotransmitters ,oxidative stress ,Psychiatry ,RC435-571 - Abstract
Depression is a common yet severe neuropsychiatric condition that causes imposes considerable personal, economic, and social burdens worldwide. Medicinal plant species (e.g., Panax ginseng and Polygala tenuifolia) demonstrate potent antidepressant-like effects with less toxicity and other side effects. Shen yuan prescription (SY), composed of Panax ginseng (GT) and Polygala tenuifolia (YT). The present study aimed to elucidate the effects of SY treatment on chronic unpredictable mild stress (CUMS) rats and study the underlying mechanism. Our results indicated that SY (67.5, 135, or 270 mg/kg) significantly reverses the depressive-like behaviors in rats with a 5-week CUMS exposure, as demonstrated by increased sucrose consumption in the sucrose preference test, and decreased immobility time in the tail suspension and forced swim test. Moreover, SY altered serum corticosterone levels, pro-inflammatory cytokines (IL-6, IL-1β, and TNF-α), and oxidative markers (SOD, CAT, and MDA), and increased the levels of hippocampal neurotransmitters (5-HT, DA, and NE) in rats exposed to CUMS. Furthermore, rats treated with SY showed a reduction in the protein expression of BDNF, p-TrkB, p-Akt, and p-mTOR proteins induced by CUMS exposure in the hippocampus. In conclusion, SY prevented depressive-like behaviors in CUMS-exposed rats by preventing hypothalamus-pituitary-adrenal axis dysfunction, decreasing the levels of the neurotransmitters, minimizing oxidative stress, suppressing neuroinflammation, and activating the PI3K/Akt/mTOR-mediated BDNF/TrkB pathway, all of which are the key players in the pathological basis of depression.
- Published
- 2021
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- View/download PDF
6. The Antidepressant-Like Effects of Shen Yuan in a Chronic Unpredictable Mild Stress Rat Model.
- Author
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Jiang, Ning, Wang, Haixia, Huang, Hong, Lv, Jingwei, Zeng, Guirong, Wang, Qiong, Bao, Yu, Chen, Ying, and Liu, Xinmin
- Subjects
GINSENG ,HYPOTHALAMIC-pituitary-adrenal axis ,IMMOBILIZATION stress ,OXIDATIVE stress ,PROTEIN expression ,PLANT species - Abstract
Depression is a common yet severe neuropsychiatric condition that causes imposes considerable personal, economic, and social burdens worldwide. Medicinal plant species (e.g., Panax ginseng and Polygala tenuifolia) demonstrate potent antidepressant-like effects with less toxicity and other side effects. Shen yuan prescription (SY), composed of Panax ginseng (GT) and Polygala tenuifolia (YT). The present study aimed to elucidate the effects of SY treatment on chronic unpredictable mild stress (CUMS) rats and study the underlying mechanism. Our results indicated that SY (67.5, 135, or 270 mg/kg) significantly reverses the depressive-like behaviors in rats with a 5-week CUMS exposure, as demonstrated by increased sucrose consumption in the sucrose preference test, and decreased immobility time in the tail suspension and forced swim test. Moreover, SY altered serum corticosterone levels, pro-inflammatory cytokines (IL-6, IL-1β, and TNF-α), and oxidative markers (SOD, CAT, and MDA), and increased the levels of hippocampal neurotransmitters (5-HT, DA, and NE) in rats exposed to CUMS. Furthermore, rats treated with SY showed a reduction in the protein expression of BDNF, p-TrkB, p-Akt, and p-mTOR proteins induced by CUMS exposure in the hippocampus. In conclusion, SY prevented depressive-like behaviors in CUMS-exposed rats by preventing hypothalamus-pituitary-adrenal axis dysfunction, decreasing the levels of the neurotransmitters, minimizing oxidative stress, suppressing neuroinflammation, and activating the PI3K/Akt/mTOR-mediated BDNF/TrkB pathway, all of which are the key players in the pathological basis of depression. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
7. En Universal Utstyrsel som Medborgarlön : Hur statliga kläder kan hjälpa till att lösa hållbarhetsproblemen i modeindustrin
- Author
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Fast, Amélie and Fast, Amélie
- Abstract
The purpose of this project is to identify issues plaguing the fashion markets poor record of sustainability andprovide a solution. This is done by identifying the issues, why they happen, how they can be solved and what the solution should look like. Thus, the project asks itself: “How would a modern revision of the concept of government clothing look like and affect us today?”. Aiding in this mission are our historic examples, sustainable development and circular economy. Historically there have been several attempts with varying success, some like the failed Utility Clothing project or the successful Kånken. Products deriving from these concepts become sustainable and healthy for the economy, the people, and the environment. To facilitate this development this study uses interviews and a self-built toolkit based on the “Dream device” where users can test, build, and mixtogether their dream garment. To create the products, sketching methods and test garments are sewn to project the design requirements into reality. This all results in four pieces of one outfit and support material that fulfills the sustainability requirements., Målet med detta projekt är att identifiera problemen med hållbarhet inom klädesindustrin och erbjuda en lösning. Detta sker genom att identifiera problemen, varför de sker, hur de kan lösas och hur lösningen bör se ut. Därförställs frågan "Hur hade en modern tappning av konceptet av statliga kläder sett ut och påverkat oss idag?".Projektet hjälps av att använda koncepten kring historiska exempel, hållbar design och cirkulär ekonomi. Historiskt sett har det funnits upprepade försök som har lyckats olika väl, till exempel det misslyckade Utility Clothing ellerden mer lyckade Kånken. Med hjälp av dessa system och exempel ska det skapas produkter som är socialt, ekonomiskt och ekologiskt hållbara. För att uppnå produktutvecklingen med dessa mål används intervjuer samt ensjälvbyggt interaktiv metod som baserar sig på ”Dream device” där deltagare kan testa, bygga och mixa sitt drömplagg. Därefter används skissmetoder utvecklade för mode för att skapa slutprodukterna. Detta resulterar ien full utstyrsel i fyra delar samt stödmaterial som inte bara hjälper deltagaren utan även lättar på bördan påekonomin och naturen.
- Published
- 2023
8. Corrigenda: A new species of Pristimantis from eastern Brazilian Amazonia (Anura, Craugastoridae). ZooKeys 687: 101–129 (2017). https://doi.org/10.3897/zookeys.687.13221
- Author
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Elciomar Araújo De Oliveira, Luís Reginaldo Ribeiro Rodrigues, Igor Luis Kaefer, Karll Cavalcante Pinto, and Emil José Hernández-Ruz
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mitochondrial DNA ,Pristimantis latro sp. nov. ,sy ,Zoology ,QL1-991 - Abstract
In this study we describe a new species of Pristimantis (Anura: Craugastoridae) of the P. conspicillatus species group. Pristimantis latro sp. nov. is known only from the municipalities of Altamira, Anapu, Brasil Novo, Medicilândia, Uruará and Aveiro (Flona Tapajós, right bank of Tapajós river), in Pará state, Brazil. Morphologically, the new species distinguishes from known congeners in the group mainly by the presence of dorsal tubercles and absence of discoidal folds, smooth belly skin, as well as the presence of supernumerary tubercles on hands. The call of the new species consists of seven ascending notes, the first of which has a dominant frequency of 2635 Hz and the last 3272 Hz. Molecular analysis of the 16S mtDNA indicates a genetic distance of 8% to P. chiastonotus, its closet relative, and between 9% and 11% to populations of P. fenestratus.
- Published
- 2017
- Full Text
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9. Mosaic surface storages of a small boreal catchment.
- Author
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Carrer, Gwenael E., Rousseau, Alain N., St ‐ Hilaire, André, and Jutras, Sylvain
- Subjects
WATERSHEDS ,PEATLANDS ,LAND cover ,WATER storage ,HYDROGEOLOGICAL modeling - Abstract
Recent studies have suggested that the hydrologic connectivity of northern headwater catchments is likely controlled by antecedent moisture conditions and land cover patterns. A water storage model ( EWS), based on water levels ( WLs), specific yield ( Sy) and surface elevation ( SE) changes, was compared with a basic water budget of a small, boreal, patterned fen (13 ha) during the ice-free period. Results showed that the EWS model reproduced well storage variations derived from the water budget. These results suggest that storage variations can be properly represented by the fluctuations of WLs when we consider the heterogeneous soil properties. However, storage deviations occurred at the daily scale and could be explained by a lack of information on water retention in unsaturated layers, canopy interceptions and preferential flows. Despite the significant impact of SE changes on the different peatland cover storage budgets (strings and lawns), using Sy mean values had a low impact on storage estimations. This can be explained by the large proportion of pools and high WLs throughout the fen. At the fen scale, high storage in the pools seemed to reduce the Sy difference between strings and lawns. The results of this study provide new insights about the complex hydrological behaviour of northern catchments and allow for conceiving new hydrological modelling perspectives. Copyright © 2014 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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10. GIS-based sediment transport in Asian monsoon region.
- Author
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Kang, S.
- Subjects
SEDIMENT transport ,MONSOONS ,GEOGRAPHIC information systems ,UNIVERSAL soil loss equation ,SOIL erosion ,MATHEMATICAL models - Abstract
Steep slope, heavy rainfall and forested cover have unique soil erosion and sediment transport in South Korea. Sediment transport pattern in the monsoon region (from June to September) is complex and sediment transport modeling in these areas is often difficult as sediment load in the river varies largely from year to year. This paper describes a GIS-based soil erosion model and then developed a sediment transport model to estimate sediment yield (SY) at different basin scales. The model for estimating suspended sediment is based on Revised Universal Soil Loss Equation and suspended delivery ratio (SDR) models. For applying SDR model, basin-specific parameter was validated on the basis of field data, which ranged from 0.6 to 1.2 based on observed SY. In the study region, the high flow rates lasted for 4 months (from July to September) and over 90 % of total SY discharged during that time. At that time, it was found that annual bed loads in this area are 56-84 % of total sediment loads. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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11. Geographic information system-coupling sediment delivery distributed modeling based on observed data.
- Author
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Lee, S. E. and Kang, S. H.
- Subjects
- *
GEOGRAPHIC information systems , *SOIL erosion , *SEDIMENT control , *MONSOON Experiment , *REVISED Universal Soil Loss Equation (RUSLE) - Abstract
Spatially distributed sediment delivery (SEDD) models are of great interest in estimating the expected effect of changes on soil erosion and sediment yield. However, they can only be applied if the model can be calibrated using observed data. This paper presents a geographic information system (GIS)-based method to calculate the sediment discharge from basins to coastal areas. For this, an SEDD model, with a sediment rating curve method based on observed data, is proposed and validated. The model proposed here has been developed using the combined application of the revised universal soil loss equation (RUSLE) and a spatially distributed sediment delivery ratio, within Model Builder of ArcGIS's software. The model focuses on spatial variability and is useful for estimating the spatial patterns of soil loss and sediment discharge. The model consists of two modules, a soil erosion prediction component and a sediment delivery model. The integrated approach allows for relatively practical and cost-effective estimation of spatially distributed soil erosion and sediment delivery, for gauged or ungauged basins. This paper provides the first attempt at estimating sediment delivery ratio based on observed data in the monsoon region of Korea. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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12. EARTHQUAKE DEATHS SURPASSES 28K IN TURKEY & SYRIA.
- Author
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MOORE, MARCUS
- Abstract
MARCUS MOORE (ABC NEWS) (Off-camera) George, good morning. For, for days, we have watched the urgent effort to find people trapped in the rubble here in Turkey, and it's unimaginable to think that the death toll could climb even higher as crews continue to search for survivors amidst the rubble here in the region. And now teams from California and Virginia are on the ground aiding in what has been a massive rescue operation. [ABSTRACT FROM PUBLISHER]
- Published
- 2023
13. The Application of Rhetorical Theory in Managerial: Research A Literature Review.
- Author
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Hartelius, E. Johanna and Browning, Larry D.
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MANAGEMENT science ,RHETORIC education ,HERMENEUTICS ,ORGANIZATIONAL behavior ,ORGANIZATIONAL research ,STRATEGIC planning ,COMMUNICATION in management ,INDUSTRIAL management ,EXECUTIVE ability (Management) - Abstract
Recent management research imports rhetorical scholarship into the study of organizations. Although this cross-disciplinarity is heuristically promising, it presents significant challenges. This article interrogates management's use of rhetoric, contrasting it with communication studies. Five themes from management research identify how rhetoric is used as an organizational hermeneutic: The article demonstrates that management research conceptualizes rhetoric as a theory and as an action; as the substance that maintains and/or challenges organizational order; as being constitutive of individual and organizational identity; as a managerial strategy for persuading followers; and as a framework for narrative and rational organizational discourses. The authors argue that organizational researchers who study rhetoric characterize persuasive strategies as managers' most important actions. [ABSTRACT FROM AUTHOR]
- Published
- 2008
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14. VAGAL NERVE STIMULATION: CLINICAL AND ELECTROPHYSIOLOGICAL EFFECTS ON VOCAL FOLD FUNCTION.
- Author
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Shaffer, Monica J, Szabo, Charles A, Jackson, Carlayne E, and Simpson, C. Blake
- Subjects
- *
VOCAL cords , *ELECTROPHYSIOLOGY , *NEURAL stimulation , *NEURODEGENERATION , *GLOTTIS , *LARYNX - Abstract
More than 16.000 vagal nerve stimulators (VNSs) have been implanted for refractory epileptic seizures. The most commonly reported side effect is hoarseness. This study examines the effects of VNS placement on vocal fold function. level patients who had undergone VNS placement at our institution were recruited. Subjective evaluation by a panel of speed and language athologists of both connected speech and videolaryngoscopy recordings were used both at rest and during VNS activation. Additional ubjective evaluation included use of the Voice Handicap Index for the study group. These results were compared to data from age- and sexmatched controls. Objective data included maximum phonation time iti the study and control groups, as well as laryngeal electromyography perft>mied on the VNS-implanted patients only. Motor unit potential morphology and recruitment, as well as spontaneous activity, were analyzed bilaterally for the cricothyroid and thyroarytenoid muscles. Significant differences were ound between the study and control groups subjectively for vocal quality and videolaryngoscopy parameters. Vocal fold tension, supragtoltic muscular hyperfunction. and reduced vocal fold mobility were the most common findings during VNS activation. Two of 10 patients had inmiohile left vocal folds in the absence of active stiniulatit>n. The maximum phonation time was generally reduced in the subject group, bul this reductitin did not reach statistical significance. Finally, 6 of 10 patients had abnormal electromy graphic results, including large-amplilude poiyphasic motor unit potentials and decreased recruitment. We conclude that implantation of a VNS can affect local fold function. The effects are magnified during periods of active stimulation. There is the potential for nerve degeneration after prolonged repetitive stimulation, and there may be a trend toward greater vocal fold dysfunction with higher stimulation parameters. [ABSTRACT FROM AUTHOR]
- Published
- 2005
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15. Anti-frosting and anti-dew device for spectroscopic measurements
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Simon Clevers, Gérard Coquerel, Sciences et Méthodes Séparatives (SMS), Université de Rouen Normandie (UNIROUEN), and Normandie Université (NU)-Normandie Université (NU)
- Subjects
PL ,RO ,PH ,VN ,PG ,TN ,TM ,PT ,RU ,Astrophysics::Cosmology and Extragalactic Astrophysics ,TZ ,RW ,TT ,RS ,UA ,SA ,(25) Filing Language: English TR ,[CHIM.ANAL]Chemical Sciences/Analytical chemistry ,[CHIM.CRIS]Chemical Sciences/Cristallography ,Astrophysics::Solar and Stellar Astrophysics ,SG ,for every ,QA ,SC ,Astrophysics::Galaxy Astrophysics ,SE ,UG ,SD ,[PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics] ,OM ,US ,SK ,SM ,ZW (26) Publication Language: English (84) Designated States (unless otherwise indicated ,SL ,SV ,SY ,[CHIM.MATE]Chemical Sciences/Material chemistry ,UZ ,ST ,[CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry ,VC ,ZA ,TH ,ZM ,TJ ,[PHYS.PHYS.PHYS-CHEM-PH]Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph] ,PE ,PA - Abstract
The present invention relates to a device for spectroscopic measurements, in particular X-ray diffraction (XRD), temperature-resolved second harmonic generation (TR-SHG) or infrared (IR) measurements, which prevents the formation of condensation (dew) or ice (frost) when carrying out spectroscopic measurements in sub-ambient temperature conditions and to a method of spectroscopic measurements with said device.
- Published
- 2019
16. The antidepressant-like effects of the water extract of Panax ginseng and Polygala tenuifolia are mediated via the BDNF-TrkB signaling pathway and neurogenesis in the hippocampus.
- Author
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Jiang, Ning, Wang, Haixia, Li, Chenchen, Zeng, Guirong, Lv, Jingwei, Wang, Qiong, Chen, Yin, and Liu, Xinmin
- Subjects
- *
ANIMAL experimentation , *ANTIDEPRESSANTS , *CELL differentiation , *CELLULAR signal transduction , *MENTAL depression , *FLUOXETINE , *GINSENG , *HIPPOCAMPUS (Brain) , *MEDICINAL plants , *CHINESE medicine , *PROTEIN-tyrosine kinases , *RATS , *PSYCHOLOGICAL stress , *PLANT extracts , *BRAIN-derived neurotrophic factor , *CHEMICAL inhibitors - Abstract
The water extract of Panax ginseng (GT) and Polygala tenuifolia (YT), the main constituents of the commonly used kai-xin-san formula of traditional Chinese medicine, represents SY. It possesses strong neuroprotective effects. Using behavioural tests, we have previously established that the SY formulation exerts superior antidepressant activity than that of GT or YT. To elucidate the impact of SY treatment on chronic unpredictable mild stress (CUMS)-induced depressive-like behaviours and the prospective mechanism related to hippocampal neurogenesis and the BDNF signaling pathway. We exposed Sprague-Dawley rats (male; 180–200 g) to CUMS for 35 days. The rats in the experimental treatment groups were daily treated with either fluoxetine (10 mg kg−1d−1) or SY (67.5, 135, or 270 mg kg−1d−1) orally until the behavioural tests (tail suspension test [TST], novelty-suppressed feeding test [NSFT], sucrose preference test [SPT], and forced swim test [FST]) were completed. We assessed the modifications in the hippocampal neurogenesis and the BDNF signaling pathway post-treatment with CUMS and SY. Additionally, K252a, a tyrosine protein kinase inhibitor, was utilized to evaluate the antidepressant mechanisms of SY. s: The results of SPT, NSFT, FST, and TST in CUMS-exposed rats confirmed the antidepressant actions of SY. Additionally, SY treatment induced the BDNF signaling pathway and reversed the hippocampal neurogenesis caused by CUMS. Moreover, we found that the TrkB antagonist K252a blocked SY effects on behavioural improvement, inhibited the incremental effects of SY on hippocampal neurogenesis, and eliminated the impact of SY on BDNF-TrkB signaling activation. Thus, the impact of SY treatment on BDNF signaling molecules (pAkt, pERK1/2, and pCREB) were significantly inhibited by K252a. This study showed that SY acted as an antidepressant in rats exhibiting CUMS-induced depressive-like behaviours, and was facilitated by promoting hippocampal neurogenesis and the BDNF signaling pathway activation. Thus, SY could act as a potential novel supplement or adjuvant to prevent or treat clinical depressive disorders. Image 1 [ABSTRACT FROM AUTHOR]
- Published
- 2021
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17. SYCO.
- Subjects
GENERAL Motors trucks ,PICKUP trucks - Abstract
The article evaluates the 1991 Scylone pickup truck from General Motors (GMC).
- Published
- 2013
18. Pictorial Paideia: Children in the Synagogue
- Author
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Sivan, Hagith, Evans Grubbs, Judith, book editor, and Parkin, Tim, book editor
- Published
- 2013
- Full Text
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19. Leaving Basie
- Author
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Terry, Gwen, editor
- Published
- 2011
- Full Text
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20. Rubber composition comprising hybrid particles
- Author
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Lucie Malosse, Julien Berriot, Damien Thomasson, Tatiana Bladé, Muriel Lansalot, Etienne Duguet, Serge Ravaine, Elodie Bourgeat-Lami, Catalyse, Polymérisation, Procédés et Matériaux (CP2M), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École supérieure de Chimie Physique Electronique de Lyon (CPE)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Bourgeat-Lami, Elodie
- Subjects
[CHIM.POLY] Chemical Sciences/Polymers ,TR ,CH-1763 Granges-Paccot (CH). TN ,VN ,Louis Braille 10 ,TM ,TZ ,TT ,UA ,SG ,SE ,UG ,SD ,US ,SK ,SM ,SL ,SV ,SY ,UZ ,Route SC ,ST ,[CHIM.POLY]Chemical Sciences/Polymers ,VC ,CHERCHE ET TECHNIQUE S.A. [CH/CH] ,ZA ,TH ,ZM ,TJ - Abstract
The invention concerns a rubber composition comprising at least a diene elastomer, a reinforcing filler and a cross-linking system characterised in that the reinforcing filler comprises hybrid particles, each particle comprising at least an organic portion and an inorganic portion: - the organic portion consisting of a polymer comprising recurring units derived from a vinyl compound, - the inorganic portion consisting of silica, - the two portions being bonded by a coupling agent likely to form the bond between the surface of the silica and said polymer, - the average size of each of the portions being between 5nm and 1 μm.
- Published
- 2013
21. As Long as You're Up Get Me a Grant.
- Subjects
CLOTHING & dress ,TAILORS - Published
- 1963
22. Default Cascades: When Does Risk Diversification Increase Stability?
- Author
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Mauro Gallegati, Bruce C. Greenwald, Stefano Battiston, Domenico Delli Gatti, and Joseph E. Stiglitz
- Subjects
050208 finance ,Financial economics ,Economics ,Financial risk ,05 social sciences ,Diversification (finance) ,Sy ,Monetary economics ,Individual risk ,Settore SECS-P/01 - ECONOMIA POLITICA ,0502 economics and business ,Financial crisis ,Systemic risk ,Default ,Always true ,050207 economics ,General Economics, Econometrics and Finance ,Default cascades ,Finance ,Credit risk - Abstract
We explore the dynamics of default cascades in a network of credit interlink-ages in which each agent is at the same time a borrower and a lender. When some counterparties of an agent default, the loss she experiences amounts to her total exposure to those counterparties. A possible conjecture in this context is that individual risk diversification across more numerous counterparties should make also systemic defaults less likely. We show that this view is not always true. In particular, the diversification of credit risk across many borrowers has ambiguous effects on systemic risk in the presence of mechanisms of loss amplifications such as in the presence of potential runs among the short-term lenders of the agents in the network.
- Published
- 2012
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23. ENU Mutagenesis Reveals a Novel Phenotype of Reduced Limb Strength in Mice Lacking Fibrillin 2
- Author
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Annabelle R. Charbit, Graham N. Askew, Sara Wells, Natalie C. Holt, Michael Cheeseman, Paul Denny, Monica Neilan, Elizabeth M. C. Fisher, Gaynor Miller, Zuzanne Lalanne, Ruth Chia, Nabeia Gheryani, Valter Tucci, and T. Neil Dear
- Subjects
Male ,Fibrillin-2 ,Fibrillin-1 ,DNA Mutational Analysis ,EXTRACELLULAR MICROFIBRILS ,MOUSE ,Mice ,0302 clinical medicine ,Congenital contractural arachnodactyly ,Genetics and Genomics/Genetics of Disease ,Genetics and Genomics/Medical Genetics ,Mice, Knockout ,Genetics ,Mice, Inbred BALB C ,Mice, Inbred C3H ,0303 health sciences ,Muscle Weakness ,Multidisciplinary ,Genetics and Genomics/Functional Genomics ,Microfilament Proteins ,SY ,MARFAN-SYNDROME ,Muscle atrophy ,Hindlimb ,Phenotype ,medicine.anatomical_structure ,Medicine ,Female ,medicine.symptom ,Fibrillin ,Research Article ,Muscle contraction ,medicine.medical_specialty ,Genotype ,Science ,Nonsense mutation ,Mutagenesis (molecular biology technique) ,Biology ,Fibrillins ,SCREENS ,03 medical and health sciences ,Internal medicine ,medicine ,Animals ,Humans ,FBN2 ,Muscle, Skeletal ,SKELETAL-MUSCLES ,Alleles ,030304 developmental biology ,Base Sequence ,MUTATIONS ,Skeletal muscle ,Muscle weakness ,DRIVEN ,medicine.disease ,GENE ,Mice, Inbred C57BL ,Endocrinology ,Genetics and Genomics/Disease Models ,Mutagenesis ,Ethylnitrosourea ,Mutation ,Syndactyly ,030217 neurology & neurosurgery - Abstract
Background\ud \ud Fibrillins 1 (FBN1) and 2 (FBN2) are components of microfibrils, microfilaments that are present in many connective tissues, either alone or in association with elastin. Marfan's syndrome and congenital contractural arachnodactyly (CCA) result from dominant mutations in the genes FBN1 and FBN2 respectively. Patients with both conditions often present with specific muscle atrophy or weakness, yet this has not been reported in the mouse models. In the case of Fbn1, this is due to perinatal lethality of the homozygous null mice making measurements of strength difficult. In the case of Fbn2, four different mutant alleles have been described in the mouse and in all cases syndactyly was reported as the defining phenotypic feature of homozygotes.\ud \ud Methodology/Principal Findings\ud \ud As part of a large-scale N-ethyl-N-nitrosourea (ENU) mutagenesis screen, we identified a mouse mutant, Mariusz, which exhibited muscle weakness along with hindlimb syndactyly. We identified an amber nonsense mutation in Fbn2 in this mouse mutant. Examination of a previously characterised Fbn2-null mutant, Fbn2fp, identified a similar muscle weakness phenotype. The two Fbn2 mutant alleles complement each other confirming that the weakness is the result of a lack of Fbn2 activity. Skeletal muscle from mutants proved to be abnormal with higher than average numbers of fibres with centrally placed nuclei, an indicator that there are some regenerating muscle fibres. Physiological tests indicated that the mutant muscle produces significantly less maximal force, possibly as a result of the muscles being relatively smaller in Mariusz mice.\ud \ud Conclusions\ud \ud These findings indicate that Fbn2 is involved in integrity of structures required for strength in limb movement. As human patients with mutations in the fibrillin genes FBN1 and FBN2 often present with muscle weakness and atrophy as a symptom, Fbn2-null mice will be a useful model for examining this aspect of the disease process further.
- Published
- 2010
- Full Text
- View/download PDF
24. Default Cascades: When Does Risk Diversification Increase Stability?
- Author
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Battiston, S., Delli Gatti, Domenico, Gallegati, M., Greenwald, B., Stiglitz, J., Delli Gatti, Domenico (ORCID:0000-0001-8819-090X), Battiston, S., Delli Gatti, Domenico, Gallegati, M., Greenwald, B., Stiglitz, J., and Delli Gatti, Domenico (ORCID:0000-0001-8819-090X)
- Abstract
In this paper we study the conditions upon which a default cascade (i.e. an avalanche of bankruptcies) can occur.
- Published
- 2012
25. Breeding Fidelity and Landscape Effects on Distribution of Mallards and Duck Broods in the Nebraska Sandhills
- Author
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Cunningham, Zachary J
- Subjects
- Mallard, Nebraska, Sandhills, Age, Ratios, Female, Male, Ducks, Waterfowl, SY, Breeding, Fidelity, Landscape, Broods, Natural Resources and Conservation
- Abstract
I investigated aspects of mallard (Anas platyrhnchos) breeding ecology in the Nebraska Sandhills during 2007-2008. Previous work in this region suggests that nest success is low for a large area of intact grassland such as the Sandhills. My goal was to conduct a local-scale examination of age distribution and return rates of mallards, and a large-scale examination of brood distribution in the Sandhills region as a whole. This information will help explain factors contributing to the low nest success previously observed, determine relationships between landscape composition and spatial distribution of waterfowl in the Sandhills, and predict productivity and abundance of ducks in the Sandhills from a spatial model. I used decoy traps to capture mallard ducks prior to nesting to ascertain age ratios and return rates for captured birds. I captured and banded 820 unique ducks representing 6 species during 2005-2008. Age distribution (SY:ASY) of mallards in 2007 was 0.9:1 for males and 6:1 for females and 0.8:1 for males and 2.3:1 for females in 2008. Mallard recapture rate was 7.4% and recovery rate was 30%. Mallard survival was 79.5% with a fidelity rate of 61.8%. I conducted road-count brood surveys consisting of three survey routes extending across the Sandhills. These presence/absence surveys were used to document the abundance and distribution of duck broods in the Nebraska Sandhills. Nine different duck species broods were observed on the survey routes in 2008. The 4 most common duck species broods observed on the survey routes were the mallard, blue-winged teal, gadwall (A. strepera), and redhead (Aytha americana). Results from the brood survey allowed me to produce a thunderstorm map predicting the probability of brood occurrence across the Sandhills. Analysis of the thunderstorm map suggests that waterfowl productivity is at its highest in the eastern Sandhills. This map will be one tool to help managers identify high priority wetland habitat that can be protected through various habitat conservation strategies by private or governmental agencies. Adviser: Larkin A. Powell
- Published
- 2011
26. Ny Tany Sy Ny Fanjakana. The land and the *state: Archaeological landscape survey in the Andrantsay region of Madagascar.
- Author
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Crossland, Zoe
- Subjects
- Andrantsay Region, Archaeological Landscape Survey, Fanjakana, Land, Madagascar, Ny, State, Sy, Tany
- Abstract
Archaeological landscape survey was carried out in the Andrantsay region of the central highlands of Madagascar. The object of the research was to place the development of the Merina state or fanjakana within a regional context. In so doing the dissertation focuses on the changing relationships between the early state center in Imerina, and its later periphery in Andrantsay, both before and after the transformations known as 'state formation' An agency based landscape approach is used to study the particular history of the Andrantsay region in order to relate it to broader regional changes throughout the central highlands from the 12th to 19th centuries AD. This approach focuses on the landscapes of Andrantsay as the outcome and medium of social practice, as changes in the landscape were created through and constrained by peoples' practices in the area. These changes are placed within the context of Merina conquest in order to understand the particular strategies used by the Merina to take over the Andrantsay region. The different choices made by local inhabitants as a response to Merina takeover, are also considered, together with the effect this had on the region.
- Published
- 2001
27. Lifespan extension by cranberry supplementation partially requires SOD2 and is life stage independent.
- Author
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Sun Y, Yolitz J, Alberico T, Sun X, and Zou S
- Subjects
- Aging physiology, Animals, Drosophila physiology, Gene Knockdown Techniques, Insulin physiology, Longevity physiology, MAP Kinase Signaling System physiology, Oxidative Stress drug effects, Plant Extracts pharmacology, Signal Transduction drug effects, Superoxide Dismutase genetics, Survival Analysis, Dietary Supplements, Longevity drug effects, Phytotherapy methods, Superoxide Dismutase physiology, Vaccinium macrocarpon
- Abstract
Many nutraceuticals and pharmaceuticals have been shown to promote healthspan and lifespan. However, the mechanisms underlying the beneficial effects of prolongevity interventions and the time points at which interventions should be implemented to achieve beneficial effects are not well characterized. We have previously shown that a cranberry-containing nutraceutical can promote lifespan in worms and flies and delay age-related functional decline of pancreatic cells in rats. Here we investigated the mechanism underlying lifespan extension induced by cranberry and the effects of short-term or life stage-specific interventions with cranberry on lifespan in Drosophila. We found that lifespan extension induced by cranberry was associated with reduced phosphorylation of ERK, a component of oxidative stress response MAPK signaling, and slightly increased phosphorylation of AKT, a component of insulin-like signaling. Lifespan extension was also associated with a reduced level of 4-hydroxynonenal protein adducts, a biomarker of lipid oxidation. Moreover, lifespan extension induced by cranberry was partially suppressed by knockdown of SOD2, a major mitochondrial superoxide scavenger. Furthermore, cranberry supplementation was administered in three life stages of adult flies, health span (3-30 days), transition span (31-60 days) and senescence span (61 days to the end when all flies died). Cranberry supplementation during any of these life stages extended the remaining lifespan relative to the non-supplemented and life stage-matched controls. These findings suggest that cranberry supplementation is sufficient to promote longevity when implemented during any life stage, likely through reducing oxidative damage., (Published by Elsevier Inc.)
- Published
- 2014
- Full Text
- View/download PDF
28. A survey of Web-based community information systems.
- Author
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Davis, Christopher Michael
- Subjects
- Community Information Systems, Survey, Sy, Web-based, World Wide Web
- Abstract
Community information systems provide a computer-based mechanism for a community to disseminate information and facilitate communication. The development of the Internet and World Wide Web has enabled the deployment of community information systems utilizing these technologies. This project surveyed those efforts with two goals. The first goal was to compare the demographics of cities, whether a city had a web site, and the relative quality of a city's web site. The second goal was to identify high quality, model sites that could be used as templates for other communities to build their own web-based community information system. To accomplish these goals, 539 cities from across the U.S. were identified. Of these, the 309 with official city web sites were surveyed using a 28-question instrument that measured the content and design of the site. The resulting analysis shows that while some demographic variables do have a significant correlation with the existence and quality of a web site, none of these variables function as a very strong predictor. This finding substantiates the need for the development of a model for web-based community information systems that can be easily adopted and utilized by communities to support the development of more effective sites.
- Published
- 1999
29. Static and dynamic behavior of serpentine belt drive systems: Theory and experiment.
- Author
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Beikmann, Randall S.
- Subjects
- Behavior, Belt Drive, Dynamic, Experiment, Serpentine, Static, Sy, Systems, Theory
- Abstract
Serpentine belt drive systems utilizing a spring-loaded tensioner provide an efficient, low-cost way to power engine accessories, but are subject to adverse dynamic response. Two main responses that may impair performance are transverse and rotational vibration. In transverse vibration, a belt span vibrates transversely to its axis. In rotational vibration, the driven accessories oscillate about their spin axes, the belt spans acting as axial springs. A theoretical model is derived which includes linear and nonlinear dynamic coupling between these two types of vibration. Belt axial speed effects are included, resulting in a gyroscopic system with continuous (belt spans) and discrete (pulleys and tensioner arm) components. The model is specialized to provide equations governing (1) nonlinear equilibrium, (2) linear vibration, and (3) nonlinear vibration. The equilibrium problem is solved, using an exact numerical solution and a closed-form approximate solution. The approximate solution produces a key parameter, $\eta,$ which measures the ability of the system to maintain system tension. The linear free vibration problem for the mixed continuous and discrete system is solved in closed-form. The eigensolutions governing free linear response are then utilized as a basis for obtaining finite degree-of-freedom approximations to the nonlinear response problem. Specifically, a three-mode expansion simulates nonlinear response with excitation and damping. The equations for the modal coordinates are integrated numerically. Experimental results are obtained, validating predictions of (1) static (equilibrium), (2) linear, and (3) nonlinear response. Analytical predictions are in very good quantitative agreement with experimental results for the equilibrium and linear free vibration problems. The nonlinear vibration problems leads to good qualitative agreement between analysis and experiment. Results show that tractive span tensions generally drop with increasing belt speed. Linear dynamic coupling between rotational and transverse motions generally produces modeshapes that are neither exclusively rotational or transverse, but include a combination of the two motions. Torque pulses input to the pulleys are shown to be capable of parametrically exciting transverse belt vibration, especially under conditions of internal resonance. As a result, knowledge of both rotational and transverse mode frequencies is critical in avoiding transverse parametric resonance.
- Published
- 1992
30. Straw men and old saws -- An evidence-based response to Sy and Tinker's critique
- Author
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Tyson, Thomas N., Oldroyd, David, Tyson, Thomas N., and Oldroyd, David
31. Straw men and old saws -- An evidence-based response to Sy and Tinker's critique
- Author
-
Tyson, Thomas N., Oldroyd, David, Tyson, Thomas N., and Oldroyd, David
32. Straw men and old saws -- An evidence-based response to Sy and Tinker's critique
- Author
-
Tyson, Thomas N., Oldroyd, David, Tyson, Thomas N., and Oldroyd, David
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