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To address the severe uplink (UL) overlapping transmission problem caused by multi-timing advance (multi-TA) in multiple transmission reception point (multi-TRP) scenario with non-ideal feedback, where existing protocols were difficult to handle effectively, a novel UL overlapping transmission handling mechanism was proposed by jointly improving physical layer multiplexing technology and medium access control (MAC) layer token bucket technology. The novel mechanism enhanced the identification process of overlapping channels at the physical layer, revised the multiplexing requirements and rules, and fed the multiplexing and overlapping information from the physical layer back to the MAC layer. Simultaneously, it optimized the token bucket technique in the MAC layer. Comparative simulations between the proposed mechanism and the processing mechanisms in existing protocols show that, in non-overlapping and overlapping logical slot scenarios, the actual number of the reused physical uplink control channel (PUCCH) performance has improved by an average of 57.58% and 49.40%, the actual available resource quantity performance of the physical uplink shared channel (PUSCH) has improved by an average of 12.09% and 26.03%, the actual occupied resource quantity of the highest priority logical channel has improved by an average of 33.33% and 45.48%.

ObjectiveTo analyze the main causes and sources of contamination， the continuous monitoring of Burkholderia gladioli contamination in the whole process of fresh wet rice noodles production and sales was monitored.MethodsThree rice noodle production enterprises were selected and all raw materials， semi-finished products， finished products and environmental samples were collected according to the process. Strain identification and cluster analysis were performed according to GB 4789.29—2020 combined with VITEK 2 COMPACT biochemical detection， PCR， and MALDI-TOF MS techniques. The bongkrekic acid in food samples， environmental samples， the enrichment fluid and venom were detected by LC-MS/MS.ResultsBurkholderia gladioli was separated and identified in 22 food samples with a detection rate of 31.9% （22/69）. After toxigenic culture， 10 strains produced bongkrekic acid. Among 67 environmental samples， only one Burkholderia gladioli toxic strain was isolated from the inner surface sample of the rice slurry pipeline. The samples with the top three detection rate were 71.4% （10/14） of rice， 66.7% （2/3） of soaked rice and 50% （6/12） of selling products. According to the regional distribution of positive samples， the raw material storage area accounted for 43.5% （10/23）， sales place for 26.1% （6/23），raw material processing area for 21.7% （5/23）， finished product packing area for 8.7% （2/23）， and no positive samples were detected in hot-cure molding area. The cluster analysis showed that positive strain from the rice slurry pipeline were highly homologous to the strains from the same batch of rice slurry.ConclusionRice may be the source of contamination in fresh wet rice noodles products enterprises. Open packaging and room temperature storage and transportation of products may be important reasons for cross-contamination， reproduction and toxicogenesis of Burkholderia gladioli. The raw materials should be separated from other production workshops to prevent the secondary pollution of the finished products. The cleaning and disinfection of the production and sales sites should be strengthened to effectively prevent and control the risk of Burkholderia gladioli contamination.

To address problems including underestimation of heavy precipitation, rapid decay of synoptic systems and low computational efficiency in operational forecast of CMA-GFS V3.3, some key technologies related to physics and dynamics of the model are developed and applied.A suite of graupel-related microphysical processes is adopted in the cloud microphysics scheme to improve the forecast performance of heavy precipitation. These processes include graupel colliding with cloud water, ice crystals and snow, automatic conversions of ice crystals to graupel and snow to graupel, melting process of graupel to raindrop and sublimation process of graupel. In addition, the evaporation rate of cloud and rainwater is restricted, which can increase the liquid water content in warm areas and improve precipitation efficiency.In the convection parameterization scheme, the role of the sub-cloud environmental relative humidity to convection triggers is considered, and the unreasonable occurrence of convections in dry environment is suppressed. Also, the sensitivity of the entrainment rate of the convective updraft to the relative humidity outside the cloud is enhanced to weaken the convections in dry environment. At the same time, the quasi-equilibrium closure scheme is optimized to improve the accuracy in calculating cloud-base mass flux which is related to the convection intensity.To solve the problem of the mass loss in long time integration, a mass conservation correction method is introduced to the model dynamic framework. The method is developed to ensure the mass conservation by adjusting mass in each grid box according to different weight coefficients which are determined by the change of total atmospheric mass of the current time step relative to the previous step.In terms of computational efficiency, the two-dimensional reference profile algorithm is developed. Without losing calculation accuracy, the model integration time step is extended from 240 s to 300 s using the new profile instead of the original three-dimensional reference profile. Meanwhile, the PCSI method is adopted instead of the GCR method, which reduces the time consuming of solving Helmholtz equation. In addition, the radiation scheme and predictor-corrector algorithms are also optimized to improve the computational efficiency.Through the application of the above key technologies, the forecasting skills for weather pattern and precipitation of CMA-GFS are significantly improved. And its computational efficiency is increased by about 1/3, which meets operational time requirement for the model with 0.125° horizontal resolution. Based on the improved model and the research achievements in other aspects of the forecast system, CMA-GFS is upgraded to V4.0 with a significantly improved comprehensive performance.

For a steel factory production of 55SiCr spring steel，the reduction of area of the oil quenched and tempered treatment wire rod after processing is less than 40%， which affects the subsequent spring coiling process and the service life of the spring. The casting billet and wire rod were evaluated by methods of low-magnification pickling test， tensile test， oil quenched and tempered treatment， drill cuttings test， etc， it was found that the center segregation of the casting billet was the main cause of poor drawing performance. Through the optimization test study of continuous casting process， the results showed that high superheat had a significant effect on the segregation of billet and the drawing performance of wire rod.When the superheat was 35 ℃ compared with 18 ℃， the reduction of area and elongation increased by 2% and 0. 8% respectively. The electromagnetic stirring current of the mold was increased from 150 A to 320 A， and the center equiaxed grain rate was increased from 8%-8. 5% to 10. 5%， but the average center carbon segregation index also increased. When using the same mould electromagnetic stirring technology， reducing the electromagnetic stirring intensity at the solidified end was beneficial to improve the center segregation. When the average center carbon segregation index of the slab decreased from 1. 10 to 1. 02， the reduction of area of the oil quenched and tempered treatment wire rod increased from 39% to 47%.

By using a column elution method, potassium copper ferrocyanide(Cu-PBA) was in situ loaded on silicon bead(SiO2) column packing, thereby yielding a SiO2/Cu-PBA fixed bed column. The characterizations of SiO2/Cu-PBA by SEM-EDS, FTIR, XRD and N2 adsorption-desorption isotherm techniques confirms the successful loading of Cu-PBA on SiO2. In batch experiments, it is found that the maximum adsorption capacity of SiO2/Cu-PBA for Cs+ is around 4.0 mg/g, and it needs 30 min to reach equilibrium adsorption. Then, the adsorpion behavior of Cs+ by the SiO2/Cu-PBA fixed bed was systematically studied, including the impacts of various operating parameters such as bed depth, bed diameter, flow rate, and influent Cs+ concentration. In the optimized fixed bed system, the adsorption behaviors of Cs+ and coexisting metal ions(K+, Na+, Ca2+, and Mg2+) by SiO2/Cu-PBA and cation-exchanged resin were compared in both simulated groundwater and seawater. The efficient and highly selective removal of Cs+ by SiO2/Cu-PBA is addressed as well as the inefficiency of cation-exchanged resin in simulated seawater. Therefore, the SiO2/Cu-PBA composite will have great application prospects in the continuous removal of Cs+ from various Cs+-contaminated environmental water media.

The study of style identification in 3D animation not only enhances the artistry of animation scenes but also has a profound significance on the development of 3D animation works. In this paper, we first sorted out the art style expressions of 3D animation and explored the innovation path of 3D animation art style and related influencing factors. Based on the generative adversarial network in AIGC technology, the discriminator and generator are trained. The 3D animation style intelligent recognition and classification model is established by combining the GAN network and SoftMax classifier, and the loss function of the model is optimized. Using crawler technology to obtain 3D animation-related images and crop them to 128*128 size for dataset construction, 3D animation style recognition and classification experiments were designed to verify the application effectiveness of the 3D-GAN model. It is found that the 3D-GAN model reaches the peak of IS index 9.222 after 60*103 iterations, which is 12.85% higher than the ALGAN model. The average classification accuracy of the 3D-GAN model is 91.42%, which is 6.01 percentage points higher than that of the sub-optimal CycleGAN model. Conducting intelligent recognition and classification of 3D animation styles based on AIGC technology can provide a new direction for innovating 3D animation styles and optimizing scene design.

In the current digital era, intelligent wearable devices have become an indispensable part of people's lives and work. Through their unique design and equipped hardware and software technologies, they enable users to quickly and efficiently acquire and process personal data, thus achieving better life and work efficiency. In these devices, wireless sensing technology plays a very important role. By combining wireless networks, sensing technology, and human-computer interaction, these devices provide rich functionality and a convenient user experience. However, the current wearable intelligent devices are lacking in specific applications, and there is a risk of data privacy leakage. Through control variable method, comparative method and experimental method, the experimental part conducted research and exploration on counting accuracy, distribution range and accuracy of heart rate measurement under different exercise states, data transmission speed under different wireless connection methods, and performance testing of wearable intelligent devices (high-temperature environment performance; low-temperature environment performance; waterproof level indicators; battery life). After testing, the overall step accuracy of the product designed in this article was above 96.5 %, and the overall measurement accuracy of heart rate under various exercise states was above 92 %. The data transmission speed is fast and stable, and the other evaluations are relatively excellent. Wearable intelligent devices based on wireless networks have broad application prospects in improving quality of life, health management, and intelligent services. With the advancement of technology and the continuous changes in user needs, wearable devices can continue to develop and bring more convenience and intelligent experiences to people's daily lives.

In this article, we study the sharp profiles of positive solutions to the diffusive logistic equation. By employing parameters and analyzing the corresponding perturbation equations, we find the effects of boundary and spatial heterogeneity on the positive solutions. The main results exhibit the sharp effects between boundary conditions and linear/nonlinear spatial heterogeneities on positive solutions.

Defects such as pores, slag inclusions, and cracks account for a high proportion of the girth weld defects of wind power towers, which seriously affect the safe operation of wind power towers. Therefore, the strength analysis of the girth welds of wind power towers with typical defects has important engineering application value. Taking a 2 MW wind power tower as the research object, we used regular hollow spheres, semi-cylinders and hollow rectangles to characterize the defects. With the failure criterion based on yield strength, the strength analysis of girth weld defects with different types, sizes and locations under three ultimate load cases was carried out. The research shows that for a single spherical pore defect, with the increase of the pore radius from 2 mm to 8 mm, the maximum equivalent stress of the girth weld of the tower increases, and the closer the pore is to the inner and outer surfaces of the wind turbine tower, the greater the maximum equivalent stress is for crack defects , the maximum equivalent stress increases with the increase of the crack defect length, but when the defect length is greater than 25 mm, the maximum equivalent stress tends to decrease. Under the Fxy, max condition, the yield strength is exceeded, which affects the safety of the wind power tower. This research will provide a theoretical reference for the safety determination of actual wind power towers with welding defects.

Abstract Objective This study aimed to evaluate the condylar positional changes following mandibular reconstruction with preservation of the condylar head using Cone-Beam Computed Tomography (CBCT). Also, to assess joint space changes and the overall volumetric space compared to the preoperative status. Methodology This prospective study included 30 patients (60 joints) subjected to unilateral mandibular resection and reconstruction with preservation of the condylar head. The Helkimo index and preoperative (T1), two weeks postoperative (T2), and follow-up CBCTs (T3) after at least six months were gathered and processed to evaluate the condylar position and TMJ joint space using Anatomage Invivo 6. A student’s t-test and repeated-measures ANOVA statistics were used. A P value of less than 0.05 was considered statistically significant. Results Thirty patients (14 males, 16 females) with a mean age of 40.01 ± 12.7 years (a range of 18.1–62.9 years) were included. On the tumor side, there were significant variances in the vertical and mediolateral condylar positions between the three-time points (T1, T2, T3). Immediately after the operation, the condyles were significantly displaced in a downward direction at T2, which became larger after the last follow-up period (T3) (p = 0.007). The condylar positions at the anteroposterior direction were relatively stable without significant differences between the three times points (p = 0.915). On the non-tumor side, the condylar positions were relatively stable in the mediolateral and anteroposterior positions. In the tumor side, all of the TMJ spaces were significantly increased in size following the mandibular reconstructions (T2 and T3). However, on the non-tumor side, the anterior, posterior, and medial joint spaces were significantly changed postoperatively. Conclusion After mandibular reconstruction with condylar preservation, the condylar position and volumetric measurement immediately changed noticeably and continued to be a permanent change over time compared to relatively stable condyles on the non-tumor side. According to Helkimo index, patients become adapted to the postoperative changes without significant differences between the two sides.

【Objective】 The internet of things (IoT) has been increasingly used to improve agricultural management over the past decades, and the purpose of this paper is to analyze its development and shift in application based on recent publications. 【Method】 We used topics and keywords to search relevant publications in CNKI and Web of Science (WOS) databases. Endnote X9 and VOSviewer were used to sort out publication data, the number of annual publications, affiliated institutions and research hotspots, from which we analyzed its development and shift. 【Result】 Application of IoT in irrigation has developed rapidly. Since 2011, CNKI and WOS have both seen a rapid growth in publications in this area. We found 300 papers in CNKI in 2020, and 280 papers in WOS in 2021. In terms of contributors, Hebei Agricultural University and Beijing Agricultural Intelligent Equipment Technology Research Center topped the list in China, while in terms of journals, Water-saving Irrigation and Agricultural Mechanization Research published the most in China. Before 2010, research in IOT in China focused on irrigation automation and since 2011 this has shifted to intelligent irrigation, integration of water and fertilizer, intelligent agricultural machinery, intelligent irrigation, and water saving. Internationally, Florida State University System and the University of Florida led other institutions, and Agricultural Water Management and Sensors are the journals that published more in this field. India, China, and America lead other countries in contributing papers, publishing 292, 220 and 184 respectively. Before 2010, the focus of IOT was agricultural production, water management and water resources regulation, and since 2011, this has shifted to agricultural production and its environmental footprints, regulation of water resources, application of irrigation technology, and intelligent irrigation. 【Conclusion】 The application of IOT technology in irrigation has shifted from automation intelligence. The future research will be to optimize software and hardware of intelligent irrigation systems, reduce costs of irrigation equipment, big data analysis and security, establish intelligent irrigation standard and training, set up efficient wireless transmission networks, and implement intelligent irrigation and fertilization.

The ventilation of fully mechanized roadway in coal mine is easy to cause the rapid diffusion of dust, which makes it more difficult to control dust pollution. In order to improve the working environment of fully mechanized coal mining face, the progress of wet dust control technology such as spray and wet dust collector in fully mechanized coal mining face treatment is summarized, and the development direction of research on dust control technology of fully mechanized coal mining face is expounded. The results show that the current spray dust suppression mainly studies the influence of different working parameters and external media on the atomization characteristics and dust suppression efficiency under the condition of no air flow disturbance; wet dust collector mainly studies the influence of power device and dust removal structure on the performance of air absorption, dust collection and dehydration. In the future, it is necessary to strengthen the test and research on the actual impact zone range of nozzles under the influence of air flow return in the fully mechanized roadway, and research and develop the nozzle that is less affected by return air wind resistant nozzles and effectively cover dust sources, develop airborne all-in-one wet dust collectors without nozzles and filters, complete frequency conversion control and linkage operation of wet dust collectors and roadheader, and realize intelligent integrated operation of spray wet dust collectors in fully mechanized mining faces.

In the fixed prosthesis process dental prosthesis treatment, the dentist needs to conceive the morphology of the tooth preparation and make numerous micro-adjustments by manual operation. This study aims to establish a digital design system for accurate designing of veneer preparation and study the trajectory planning of the robot-assisted preparation. According to the standard operation requirements, the projection line segmentation method based on point drawing is proposed for interactive selection to ensure the margin smoothness of the preparation area. The preparation depth is parameterized, and the foldback point correction method based on secondary segmentation is used for repairing the offset preparation area to ensure surface smoothness. The fenestration preparation model was obtained in the digital interactive design software. The model is divided into two feature areas which are interpolated by the B-spline curve and NURBS surface, respectively. The isoparametric curve method is used to plan the preparation trajectory. The experimental and theoretical values of the target feature points from the X, Y and Z coordinate directions were also calculated and analyzed. The experiment is carried out by the physical prototype of the tooth preparation robot. The maximum error of the feature points on the preparation are 0.180 mm, 0.104 mm and 0.142 mm in X, Y and Z directions, respectively. The confidence interval of the system error is stable within 0.30 mm. The error of the feature points verifies the feasibility of the digital interactive design system and the correctness of the trajectory planning of tooth veneer preparation. The system could have the potential to assist dentists in the precise design of the veneer preparation, improve the processing efficiency and ensure the effect of tooth veneer prosthesis.

Objective: This study aimed to investigate the pollution of heavy metals in Astragalus membranaceus in the main producing areas of Gansu, and to evaluate the potential health risks of edible Astragalus membranaceus. Methods: The contents of five heavy metal elements Pb, Cd, As, Hg and Cu in Astragalus membranaceus were determined by inductively coupled plasma mass spectrometer （ICP-MS） by random sampling method, and the data were analyzed. Estimated Daily Intake （EDI）, Target Hazard Factor （THQ） and Lifetime Carcinogenicity Risk （LCR） were used for health risk assessment. Results: The average contents of Pb, Cd, As, Hg, and Cu elements in 58 batches of Astragalus membranaceus samples were 0.148, 0.024, 0.139, 0.011 and 4.569 mg/kg, respectively. According to the limited standards stipulated in the 2020 edition of the Chinese Pharmacopoeia, although the detection rate of individual elements was high, but none of them exceeds the standard. The health risk assessment model showed that EDICu＞Pb＞Hg＞Cd, and all less than 1, LCR was also less than 1×10-6. Indicated that the overall level of Astragalus membranaceus samples in this study was safe. Conclusion: The content of five heavy metals in Astragalus membranaceus produced in Gansu will not cause potential risks to the health of adults and children, and there is no potential carcinogenic risk.

CO2 mineralized all-solid waste alkali-activated cementitious materials can not only realize the storage of CO2 mineralized, but also shorten the curing cycle of alkali-activated cementitious materials and improve their compressive strength. It is a promising way of CO2 capture and utilization. The effects of the ratio of alkali-activated cementitious materials, mineralized curing pressure and mineralized curing time on the carbon fixation rate and compressive strength of CO2 mineralized cementitious materials were studied. The results show that the calcium carbide slag as alkali activator is more suitable for mineralization curing, and the sample with the highest Ca/Si ratio has the best carbon fixation ability under the same curing condition. Increasing the curing pressure and curing time of CO2 can improve the properties of the samples. Physical and chemical characterization test results show that, the microstructure of the mineralized samples is more compact than that of the natural curing samples, and the calcite-type calcium carbonate produced in the curing process is helpful to increase the compressive strength of the material. The research results provide basic data and reference for the development of CO2 mineralization curing technology of all-solid waste alkali-activated cementitious materials.

ObjectiveAn analytical method was developed for the qualitative screening of 52 illegally adulterated weight-losing compounds in foods by ultra high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry.MethodsThe samples were extracted by methanol. Waters CORTECS T3 column （100 mm×2.1 mm， 2.7 μm） was used with acetonitrile -0.1% formic acid aqueous solution as mobile phases by gradient elution. The compounds were detected by electrospray ionization mass spectrometry and Q-TOF-MS detector in positive and negative ion mode. A standard spectrum library was established by reference standards， and the qualitative analysis was finished by the comparison of the retention time， parent ion and fragment ion accurate molecular mass of each compound in the sample and the library.ResultsThe method was specific without interference of blank matrix， and repeatable in sextuplicate. The detection limits of 52 compounds in 5 matrix were 1‒100 mg‧kg-1. The method was successfully applied to the analysis of actual samples，and 16 compounds were checked out in 246 samples.ConclusionThe method is accurate， specific and sensitive， which can be used to combat the illegal adulteration behavior effectively.

Objective To explore expression changes of high affinity IgG receptor Fc-gamma Ⅰ type(FcγRⅠ) in brain cortex of patients with Alzheimer's disease(AD). Methods Normal human brain tissue samples and brain tissue samples with neuropathological diagnosis of AD, wild type mice and APP/PS1 mice were used. Immunofluorescence and Western blot were used to define cellular localization and expression of FcγRⅠ in cerebral cortex. Results FcγRⅠ was generally expressed in neurons of human and mouse cerebral cortex. Compared with normal human brain, FcγRⅠ expression in AD human brain cortex decreased significantly(P＜0.05). Compared with wild type mouse brain, FcγRⅠ expression in cerebral cortex of AD mouse models also decreased significantly(P＜0.05). Conclusions The expression of IgG high affinity receptor FcγRⅠ in AD human brain and cerebral cortex of AD mouse models decreases significantly that suggestes that FcγRⅠ is potentially correlated with AD neuropathological pathogenesis.

ObjectiveTo investigate a black fungus poisoning incident in Shenzhen and identify the specie of pathogen. Meanwhile， the toxogenic strains， the distribution and metabolism of bongkrekic acid （BA） in vivo were also studied to provide references for treatments of similar incidents.MethodsIsolation and identification of pathogenic bacteria were carried out according to GB/T 4789.29-2003. MALDI-TOF MS was also used. UPLC-QTRAP-MS/MS was used for determination of BA in Black Fungus， blood， liver， urine， bacterial suspension and other samples.ResultsDifferent concentrations of BA were found in soaked Black Fungus， blood and urine samples. BA was also found in necrotic liver acquired from liver transplant 5 days after BA intake. Continuous surveillance showed that certain concentration of BA still exist in patient’s blood and urine even 9 days after BA intake. Burkholderia gladioli were isolated from both dried and soaked Black Fungus， and both two strains produced abundant BA after bacilli-culture.ConclusionBurkholderia gladioli in the Black Fungus produced large amount of BA during the soaking process. Then BA was ingested by the patient and widely distribute in vivo. Consequently， the patient died of multiple organ failure.

Objective To analysis of risk factors for stress ulcers after the surgery of acute cerebral hemorrhage, and use these factors to construct a Nomogram model. Methods In this study, 300 patients with acute cerebral hemorrhage treated in The First Affiliated Hospital of University of Science and Technology of China between January 2015 and November 2020 were recruited and divided into stress ulcers group (53 patients) and non⁃ulcers group (247 patients) according to whether the postoperative period was complicated by stress ulcers. Univariate and multivariate stepwise Logistic regression were used to assess the risk factors for stress ulcers after the surgery of acute cerebral hemorrhage and the Nomogram model was established. The receiver operating characteristic (ROC) curve and calibration curve of the model were plotted, and Hosmer⁃Lemeshow goodness of fit test was performed. Results Logistic regression showed that age increased (OR=1.043, 95%CI: 1.059-1.086; P=0.042), Glasgow Coma Scale (GCS) score≤8 (OR=2.809, 95%CI: 1.018-7.740; P=0.044), the cerebral hemorrhage volume≥30 ml (OR=3.830, 95%CI: 1.342-10.933; P=0.012), neutrophil to lymphocyte ratio (NLR) increased (OR=1.090, 95%CI:1.032-1.151; P=0.002), the increase of postoperative systolic blood pressure (OR=1.031, 95%CI: 1.008-1.055; P=0.008) and postoperative intracranial infection (OR=2.809, 95%CI: 1.006-7.847; P=0.049) were the risk factors for stress ulcers after the surgery of acute cerebral hemorrhage. The Nomogram model was established based on the 6 risk factors, and the area under curve (AUC) of ROC was 0.881 (95%CI: 0.821-0.942, P=0.001); the best cut⁃off value for predicting the risk of acute postoperative cerebral hemorrhage complicated by stress ulcers was 137. The calibration curves showed good agreement between the predicted and actual probabilities, and the Hosmer⁃Lemeshow goodness of fit test showed there was no statistical difference (χ2=7.891, P=0.445), indicating that the Nomogram model has good discrimination, calibration and stability. Conclusions Over⁃age, GCS score≤8, cerebral hemorrhage volume≥30 ml, NLR increase, postoperative systolic blood pressure increase and intracranial infection were the risk factors for stress ulcers after the surgery of acute cerebral hemorrhage. In conclusion, this Nomogram model is able to individually, visually and briefly predict the risk of postoperative complications of stress ulcers in patients after the surgery of acute cerebral hemorrhage.

In order to analyze the flow characteristics of the internal flow field in the working chamber of the oil-free double-warp scroll compressor, a three-dimensional unsteady numerical simulation of the internal flow field in the working chamber of the compressor is conducted based on the computational fluid dynamics (CFD) method. In order to verify the deviation between the numerical simulation and the actual working process, a test platform for scroll compressors using air as the working medium is built, and the actual output performance parameters of the oil-free double-warp scroll compressor are obtained. The results show that the mass exchange between adjacent working chambers has a greater impact on the working chamber and the distribution of temperature and velocity along the tooth height direction, but has a little impact on pressure. The inlet and outlet mass flow and velocity rate change periodically, and as the compressor speed increases, the theoretical volume flow increases.

ObjectiveTo determine the management of family planning technology services in Changning District of Shanghai over the past decade， and to explore the key populations and service patterns along with changing family planning policy， so as to provide evidence for further family planning services and management.MethodsBased on the routine statistics， family planning surgery， management of key populations， management of surgery quality， and contraceptive counseling from 2011 through 2020 in Changning District were retrospectively reviewed.ResultsThe number of family planning surgery， induced abortion， midtrimester induced abortion， live births， and birth to induced abortion ratio has decreased. Majority of those who received induced abortion were non-local married women， whereas those under 19 years were principally non-local unmarried ones. In total， contraceptive counseling decreased among newly married couples and in the community. Postpartum contraceptive counseling guidance remained at a low level. Furthermore， the number of IUD placements and subcutaneous implants has reduced， suggesting the acceptance of highly effective methods of contraception needs to be improved. The percentage of immediate IUD placement following induced abortion gradually increased. In addition， the percentage of high-risk family planning surgery showed a decreasing trend， however， serious surgical complications remained.ConclusionWith the “universal two-child” policy， the number of family planning surgery， especially induced abortions， has decreased significantly. It warrants a demand-driven family planning services， including strengthening the multiple health education and promoting to having a second child for key populations. Moreover， we should optimize the service process， strengthen the professional training for relevant clinicians and staff， and improve the quality of services for ensuring the mother and child health.

In order to obtain the equivalent elastic parameters of its macro-scale structure, the tensile properties of 2D 1×1 braided composite cell model was simulated, and the stress distribution law and load displacement relationship of the structure were obtained. Based on elastic theory, the equivalent elastic modulus of unit cell model was used to characterize the elastic properties of 2D braided composites. The effects of different braiding angles on the equivalent elastic modulus of braided composites were further analyzed. The results show that the stress of the fiber bundle and the matrix in the unit cell model decreases with the increase of the braiding angle; and as the main carrier, the stress of the fiber bundle is much higher than that of the matrix; and the equivalent elastic parameters in the braiding direction decrease with the increase of braiding angle.

Blood–brain barrier participates in the pathological process of ischemic stroke. MicroRNA-29c-5p was highly expressed in clinical samples from patients with ischemic stroke. In this study, oxygen-glucose deprivation (OGD) treatment of astrocytes enhanced the permeability of brain microvascular endothelial cells (BMECs), and the miR-29c-5p expression was elevated in clinical samples from patients with ischemic stroke. For the function of miR-29c-5p in ischemic stroke, the miR-29c-5p knockdown decreased the permeability and the tight junction protein (TJP) destruction of BMECs and ameliorated the inflammation induced by OGD-treated astrocytes. Mechanistically, miR-29c-5p interacted with lipoprotein receptor-related protein 6 (LRP6) and negatively regulated the LRP6 expression in astrocytes. Moreover, the rescue assays indicated that the interference with miR-29c-5p ameliorated the TJP destruction of BMECs and inflammation caused by OGD-treated astrocytes by increasing the LRP6 expression. Together, miR-29c-5p knockdown decreased the high permeability and the TJP destruction of BMECs and ameliorated the inflammation induced by OGD-treated astrocytes by elevating LRP6 expression.

Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis characterized by the infiltration of bone and multiple organs by foamy lipid-laden histiocytes. ECD is easy to be misdiagnosed due to its complicated clinical manifestations. We report a patient who visited the hospital due to hypothalamic dysfunction, with central nervous system, pancreas, and lower limb bones involvements. Together with the evidence of clinical manifestations, imaging and pathology, this patient was diagnosed with ECD. After treatment with interferon-α, both the clinical symptoms and imaging manifestations of this patient were significantly improved.

Arthrospira platensis has attracted wide attention as a cyanobacteria with high nutritional value. In this research, the response surface method was used to study the effects of light cycle, light intensity and red-blue LED conditions on the growth and organic matter accumulation in spiral shaped strain A. platensis OUC623 and linear shaped strain A. platensis OUC793. The light conditions suitable for A. platensis OUC623 were as follows: growth (light time 12.01 h, light intensity 35.64 μmol/m2s, LED red: blue = 6.38:1); chlorophyll a (light time 12.75 h, light intensity 31.06 μmol/m2s, red: blue = 6.25:1); carotenoid (light time 13.12 h, light intensity 32.25 μmol/m2s, red: blue = 5.79:1); polysaccharide (light time 16.00 h, light intensity 31.32 μmol/m2s, blue: red = 6.24:1); protein (light time 12.18 h, light intensity 6.12 μmol/m2s, blue: red = 7.95:1); phycocyanin (light time12.00 h, light intensity 5.00 μmol/m2s, blue: red = 8.00:1). The light conditions suitable for A. platensis OUC793 were as follows: growth (light time 13.52 h, light intensity 40.22 μmol/m2s, red: blue = 5.98:1); chlorophyll a (light time 14.22 h, light intensity 44.96 μmol/m2s, red: blue = 5.94:1); carotenoid (light time 14.13 h, light intensity 44.50 μmol/m2s, red: blue = 6.02:1); polysaccharide (light time 16.00 h, light intensity 31.85 μmol/m2s, blue: red = 6.08:1); protein (light time12.00 h, light intensity 5.00 μmol/m2s, blue: red = 8.00:1); phycocyanin (light time12.01 h, light intensity 5.01 μmol/m2s, blue: red = 8.00:1). Under the theoretical optimal light conditions, compared with white LED, the growth rate, chlorophyll a, carotenoid, phycocyanin, protein and polysaccharide contents in strain 623 increased by 91.67%, 114.70%, 85.05%, 563.54%, 386.14%, 201.18%, and in strain 793 increased by 75.00%, 150.94%, 113.43%, 427.09%, 1284.71%, 312.38%, respectively. The two strains showed different advantages. Growth rate, chlorophyll a, polysaccharide, protein and phycocyanin content of strain 623 were higher than those of strain 793, while carotenoid was higher in strain 793. After optimization, both strains could reach a good growth state, and the growth rate and organic matter content were close. And then a 20 L photobioreactor was used to expand the culture of the two strains, validating the theoretical optimal light conditions of response surface method. This study laid the foundation for the establishment of optical conditions for organic matter accumulation in two different strains of A. platensis, which provided more options for meeting the industrialization needs of A. platensis.

This paper analyzes the behavior of the positive solution θε{\theta_{\varepsilon}} of the perturbed problem

Over the past 30 years, super rice played an important role in boosting rice yield. The phenotype of erect panicle (EP) architecture controlled by dense and erect panicle 1 (dep1) is the typical characteristic of super rice, and the phenotype has been used in rice breeding for nearly a century. In this review, the molecular genetic basis of EP phenotype, and mechanism of how dep1 affects rice carbon, nitrogen metabolism and grain quality (grain shape and taste quality) were discussed. In addition, we discussed the possible improvement strategies of rice yield and quality. This review provides a quick overview of the whole process for rice quality formation, as well as suggestions and ideas for future research on rice quality improvement.

Objective To investigate the staining and tracing effect of mitoxantrone hydrochloride injection for tracing lymph nodes in radical thyroidectomy, and its safety and tolerability. Methods In this study, a single-centered, open-labeled, blank control trial was designed. According to the principle of dose escalation, the human tolerance test and kinetic test were performed in dose groups one by one. Patients scheduled for radical thyroidectomy in Peking Union Medical College Hospital from December 2016 to March 2017 were prospectively enrolled as subjects. The subjects were divided into the blank control group and the test groups. The blank control group routinely underwent surgery without tracer injection; the test groups were injected with 0.2 mL, 0.4 mL, 0.6 mL, 0.8 mL, or 1.2 mL of mitoxantrone hydrochloride for tracing in the thyroid gland after exposing the surgical field, and an escalation test was performed in the five dose groups from low to high. The primary efficacy measures were lymph node tracing rate and lymph node staining rate; the secondary efficacy measures were staining-degree scores of lymph nodes and the success rate of tracing persistence. Changes in signs of subjects were recorded for safety assessment. Venous blood was collected from the subjects before administration and at 10 min, 20 min, 30 min, 60 min, 90 min and 120 min after administration to calculate the kinetic parameters. Results A total of 27 subjects were included, including 3 subjects in the blank control group, and 3, 3, 6, 6 and 6 subjects in the 0.2 mL, 0.4 mL, 0.6 mL, 0.8 mL and 1.2 mL dose group, respectively. When the test proceeded to the third dose group (0.6 mL), the injection site of the subjects was saturated with the injection dose, and the test was terminated. Therefore, a total of 15 subjects completed the test. No lymph node was stained in blank control group.The lymph nodes of 12 subjects showed blue staining, and the parathyroid glands were not stained and negatively visualized. There was significant difference in the staining-degree scores of lymph nodes before and after administration in the 0.2 mL, 0.4 mL and 0.6 mL dose groups (P < 0.05). The average staining rates of lymph nodes were 90.47%, 91.67% and 91.36%, respectively. And the average tracing rates of lymph nodes were 79.17%, 100% and 98.67%, respectively. In the test groups, the duration of lymph node dissection was 5-20 min; no stained lymph nodes faded, and the success rate of tracing was 100%. In the safety evaluation, no serious adverse events occurred in the blank control group and test groups, and the cause of adverse events was certainly not related to this tracer. Kinetic tests showed that the tracer was rapidly absorbed after glandular injection; the blood concentration peaked at 10 min after injection (the maximum plasma concentration was 13.1 μg/L) and it was rapidly eliminated. Conclusions The use of 0.2-0.6 mL mitoxantrone hydrochloride injection in radical thyroidectomy can play a better role in tracing lymph nodes, with high safety and good tolerance.

Objective: This study aimed to solve the problems of time consuming and high cost in the natural aging process. Methods: Black rice wine was treated with different microwave power, time and temperature. The contents of main phenols, organic acids, and esters in black rice wine treated by microwave technology were analyzed. Results: Microwave treatment could increase the contents of total esters, protocatechuic acid, gallic acid, syringic acid, acetic acid, ethyl valerate and ethyl acetate, reduce the contents of total phenols, total acids, caffeic acid, citric acid, tartaric acid, lactic acid and ethyl lactate, and have little effect on the contents of oxalic acid and malic acid. Conclusion: Three kinds of black rice wine with similar substance change trend to the natural aging can be produced in a short time, by using microwave treatment at 100 W, 40 ℃, for 3 min or 6 min.

Direct-seeding of rice has become popular in recent years due to its low cost and convenience, however, hypoxic condition limits seedling establishment. In this study, weedy rice WR04-6 with high germination ability under anaerobic conditions was used as a gene donor, and we successfully improved the seedling establishment rate of rice cultivar Qishanzhan (QSZ) based on selection of a new rice line R42 from the recombinant inbred line population. R42 inherited high anaerobic germination (AG) ability, and was used for isobaric tags for relative and absolute quantitation (iTRAQ)-based comparative proteomic studies with QSZ to further explore the molecular mechanism of AG. A total of 719 differentially abundant proteins (DAPs) were shared by R42 and QSZ responded to AG, and thus defined as common response DAPs. A total of 300 DAPs that responded to AG were only identified from R42, which were defined as tolerance-specific DAPs. The common response and tolerance-specific DAPs had similar biochemical reaction processes and metabolic pathways in response to anoxic stress, however, they involved different proteins. The tolerance-specific DAPs were involved in amino acid metabolism, starch and sucrose metabolism, tricarboxylic acid cycle pathway, ethylene synthesis pathway, cell wall-associated proteins and activity of active oxygen scavenging enzyme. The in silico protein-protein interactions for the top 60 DAPs indicated that tolerance-specific DAPs had relatively independent protein interaction networks in response to an anoxic environment compared with common response DAPs. The results of physiological indicators showed that α-amylase and superoxide dismutase activities of R42 were significantly increased under anoxic conditions compared with aerobic conditions. Multiple lines of evidence from western blot, physiological analysis and quantitative real-time PCR jointly supported the reliability of proteomics data. In summary, our findings deepened the understanding of the molecular mechanism for the rice response to AG.

Multiple unmanned system cooperation is an important component of China’s new-generation artificial intelligence (AI) planning and it is a transformative technology for future national defense construction and social development of China. Although significant achievements have been made regarding the technological research and system integration of multiple unmanned system cooperation, research on AI security is still in its infancy. Promoting multiple unmanned system cooperation enables AI application and risk control. In this article, we propose a four-in-one strategy to promote the collaborative and secure development of multiple unmanned systems, investigate potential challenges and countermeasures for multiple unmanned system cooperation at the endogenous and derivative security levels, and propose several suggestions regarding the security of intelligent unmanned systems. Specifically, a national unmanned system verification platform should be established to promote the construction of talent teams; services need to be upgraded for the unmanned system industry to develop a new-generation AI security ecology; and the advantages of multiple unmanned system cooperation should be maximized to improve people’s livelihood.

Polycrystalline Ni-Mn-Ga-Fe fibers were prepared by melt-extraction technique. The internal stress and defects introduced by rapid solidification were modified by step-wise chemical ordering annealing. The microstructure and phase microstructure of fibers were characterized using Field Emission Scanning Electron Microscope (FESEM) and Transmission Electron Microscopy (TEM) and XRD diffraction technique. The phase transition behavior and two-way shape memory effect (TWSME) were tested using Dynamic Mechanical Analyzer (DMA). The results show that after heat treatment, the chemical ordering degree is increased, and the martensite twin boundaries are straight. Complete recoverable strains of parent and martensite phases during thermal cycles are achieved. During the two-way shape memory cycles, two characteristics of thermoelastic martensite transition are displayed in heat-treated fibers: reversibility and thermal hysteresis. In the thermal cycle test, the total strain reaches 1.32% when the fiber is loaded to 198 MPa. The thermomechanical tensile measurement shows that the phase transition temperature follows the Clausius-Clapeyron equation. Compared with other alloys such as Ti-Ni and Cu-Al-Ni, Fe-doped fiber exhibits a smaller strain-stress dependence, which is beneficial to the constant strain output.

Na+ ⁃ K+ ⁃ 2Cl- cotransporter 1 (NKCC1) which plays an important role in the dynamic balance of Cl- ions, is one of the cation⁃chloride cotransporter. It is a membrane protein that transferred the mediates Na+ , K+ and Cl- . The expression quantity or activity of NKCC1 changes with the changes in physiological and pathological conditions, thereby regulating the intracellular concentration of Cl- and the excitability of neurons. This article reviews the NKCC1's expression and regulation mode of activity as well as the effects of NKCC1 in the pathogenesis of various neurological diseases and the effects in the treatment, aiming at providing theoretical clues for the relevant future studies. doi：10.3969/j.issn.1672⁃6731.2021.03.016

Numerical weather prediction technology plays an increasingly important role in improving accuracy and service level of modern weather forecast. With the development of observation system and higher resolution and complexity of the numerical weather prediction model, the products of numerical weather forecast have been greatly improved in quantity and quality, and can offer rich information at high spatial-temporal frequency. However, such a large amount of prediction data are not fully explored. Artificial intelligence has achieved great success in many fields, such as pattern recognition and natural language processing, which provides an opportunity for further improving numerical weather prediction. It's also employed in initialization, numerical model and production of weather forecast service, involving observation system, data assimilation, model integration, ensemble forecast and high-performance computing methods. Both the accuracy of forecast results and computational efficiency have been improved by using error correction, parameter estimation, local surrogate model and so on. In addition, some end-to-end neural network models also show the potential of pure data-driven weather forecast. These models use spatial-temporal observation data as input and directly output the prediction results in terms of deterministic results or probabilities. Some of them perform well in short-term severe convective weather, precipitation, and long-term climate forecast. Existing works employ various artificial intelligence technology methods, mainly including large-scale calculation of neural network, feature analysis, interpretability, and customized loss function. However, there are still some challenges, the potential of artificial intelligence needs to be further explored. Some issues should be carefully considered, including weak interpretability, uncertainty analysis and the coupling with conventional numerical models, and how to use physical knowledge to guide the design of artificial intelligence model is also worth addressing. To deal with these challenges, some promising suggestions are proposed. Bayesian network and causal network will help to establish more comprehensive and profound feature engineering. Using Bayesian inference to generate distribution characteristics of current meteorological states may be an alternative to efficient and effective uncertainty quantification. The development of some standard workflow and framework will contribute to the coupling of conventional numerical model and artificial intelligence module. Successful artificial intelligence applications in weather forecast require deep cooperation between meteorological experts and computer experts who focus on artificial intelligence and high-performance computing.

Piezoelectric energy harvesting devices (PEHDs) for road installation are being researched as potentially low-emission electrical generators, but their life cycle greenhouse gas (GHG) emissions must be assessed to guide their design and implementation toward minimizing their carbon footprint. Parametric life cycle assessments (LCAs) of a PEHD, its generator, and the piezoelectric material were performed using data from a pilot-scale PEHD installation. The GHG emissions of the lead zirconate titanate (PZT) piezoelectric stack were determined to be lower than previously reported in the literature at 10.81-15.90 kg CO2eq/kg piezoelectric. The GHG emissions of electricity generated by a PEHD range from 48.65-588.63 g CO2eq/kWh, spanning from similar to renewables to slightly higher than electricity from natural gas. Sensitivity analysis indicated that spatial parameters and the device lifetime had the largest influence on the LCA results. PEHDs installed on roads show potential to be low-GHG emission energy systems.