1. Trailblazing in adjuvant research: succinate's uncharted territory with neutrophils.
- Author
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Wang, Yangyang, Xiu, Zhiming, Qu, Kuo, Wang, Liying, Wang, Huiyan, and Yu, Yongli
- Subjects
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B cells , *INTERFERON receptors , *NEUTROPHILS , *ANTIBODY formation , *IMMUNE response , *SUCCINATES , *IMMUNOREGULATION , *CELLULAR signal transduction - Abstract
The purpose of this study is to investigate the previously unknown connection that succinate has with neutrophils in the setting of adjuvant-mediated immunological enhancement. It has been discovered that succinates stimulate the recruitment of neutrophils in immunization sites, which in turn induces the expression of what is known as neutrophil-derived B cell-activating factor (BAFF). Further amplification of vaccine-induced antibody responses is provided via the succinate receptor 1-interferon regulatory factor 5 (SUCNR1-IRF5)-BAFF signaling pathway, which provides insights into a unique mechanism for immunological enhancement. NEW & NOTEWORTHY: This study explores the role of succinate as a vaccine adjuvant, revealing its capacity to enhance neutrophil recruitment at immunization sites, which boosts B cell activation through the succinate receptor 1-interferon regulatory factor 5-B cell-activating factor (SUCNR1-IRF5-BAFF) signaling pathway. Results demonstrate succinate's potential to amplify vaccine-induced antibody responses, highlighting its significance in immunological enhancement and offering new insights into the adjuvant mechanisms of action, particularly in neutrophil-mediated immune responses. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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