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No study has assessed supramaximal (over 100% 1RM) back squat variations as a potentiating stimulus in collegiate throwers. The purpose of this study was to test the hypothesis that a supramaximal Anderson (bottom-up) quarter squat potentiating stimulus would improve discus throw performance in Division I throwers compared to a dynamic warm-up alone. Nine NCAA division I thrower athletes (age: 20.1±1.4 years; 1RM back squat/body weight: 2.5±0.4 kg) randomly completed two sessions separated by at least 72 hours. One session involved a standardized dynamic warm-up alone (DyWU) followed by three trials of maximal discus throwing. The other session involved a dynamic warm-up with a supramaximal (105% 1RM) Anderson (bottom-up) quarter-squat set of 5 repetitions post activation performance enhancement stimulus (DyWU+PAPE) followed by three trials of maximal discus throwing. A two-way (warm-up strategy x time) ANOVA with repeated measures for each time point was used, with significance set at p< 0.05. There were no significant (p> 0.05) differences between DyWU alone versus DyWU+PAPE stimulus for discus throw distances at either 8 min. (31.7±5.6 vs 30.6±6.5 meters, respectively; d = -0.18), 11 min. (33.4±3.6 vs 31.3±4.7 meters, respectively; d = -0.52), or 14 min. post warm-up (34.1±3.9 vs 32.3±5.3 meters, respectively; d = -0.40). Compared to a dynamic warm-up alone, supramaximal Anderson quarter-squats following a dynamic warm-up had trivial/small to moderate detrimental effects on discus throw performance between 8-14 minutes post stimuli in Division I trained throwers, likely due to excess fatigue/PAPE inhibition. [ABSTRACT FROM AUTHOR]

This study examined the influence of stimulus properties on sound externalization when listening with hearing aids. Normally hearing listeners were presented with broadband "tokens" (environmental sounds and speech) from loudspeakers, and rated externalization using a continuous scale. In separate blocks, they listened unaided or while wearing behind-the-ear hearing aids with closed domes and low gain (linear or compressive). There was a significant influence of token on ratings, even for unaided listening, and the effect of hearing aids depended on token. An acoustic analysis indicated that hearing aids were more likely to disrupt externalization for peakier sounds with a low-frequency emphasis. [ABSTRACT FROM AUTHOR]

Music is an important signal class for hearing aids, and musical genre is often used as a descriptor for stimulus selection. However, little research has systematically investigated the acoustical properties of musical genres with respect to hearing aid amplification. Here, extracts from a combination of two comprehensive music databases were acoustically analyzed. Considerable overlap in acoustic descriptor space between genres emerged. By simulating hearing aid processing, it was shown that effects of amplification regarding dynamic range compression and spectral weighting differed across musical genres, underlining the critical role of systematic stimulus selection for research on music and hearing aids. [ABSTRACT FROM AUTHOR]

A novel motion stimulus is perceived to last longer than the subsequent motion stimulus moving in the opposite direction. A previous study suggested that the discrepancy in the processing latency for different onset types, as measured by reaction time, may play a role in this duration expansion. The present study examined whether the speed of motion stimuli influences this duration expansion. Experiment 1 demonstrated that the duration expansion ceased to occur when the stimulus speed increased. Experiment 2 showed that the increase in the speed reduced the reaction time for various onset types. However, the size of the changes in the reaction time did not match the reduction in the magnitude of the duration expansion observed in Experiment 1. These results suggest that the increase in speed eliminates the duration expansion of the novel motion stimulus, but the difference in the processing latency alone may not be the sole mechanism. [ABSTRACT FROM AUTHOR]

Background: Abnormal neuronal synchrony is associated with several neurological disorders, including Parkinson's disease (PD), essential tremor, dystonia, and epilepsy. Coordinated reset (CR) stimulation was developed computationally to counteract abnormal neuronal synchrony. During CR stimulation, phase-shifted stimuli are delivered to multiple stimulation sites. Computational studies in plastic neural networks reported that CR stimulation drove the networks into an attractor of a stable desynchronized state by downregulating synaptic connections, which led to long-lasting desynchronization effects that outlasted stimulation. Later, corresponding long-lasting desynchronization and therapeutic effects were found in animal models of PD and PD patients. To date, it is unclear how spatially dependent synaptic connections, as typically observed in the brain, shape CR-induced synaptic downregulation and long-lasting effects. Methods: We performed numerical simulations of networks of leaky integrate-and-fire neurons with spike-timing-dependent plasticity and spatially dependent synaptic connections to study and further improve acute and long-term responses to CR stimulation. Results: The characteristic length scale of synaptic connections relative to the distance between stimulation sites plays a key role in CR parameter adjustment. In networks with short synaptic length scales, a substantial synaptic downregulation can be achieved by selecting appropriate stimulus-related parameters, such as the stimulus amplitude and shape, regardless of the employed spatiotemporal pattern of stimulus deliveries. Complex stimulus shapes can induce local connectivity patterns in the vicinity of the stimulation sites. In contrast, in networks with longer synaptic length scales, the spatiotemporal sequence of stimulus deliveries is of major importance for synaptic downregulation. In particular, rapid shuffling of the stimulus sequence is advantageous for synaptic downregulation. Conclusion: Our results suggest that CR stimulation parameters can be adjusted to synaptic connectivity to further improve the long-lasting effects. Furthermore, shuffling of CR sequences is advantageous for long-lasting desynchronization effects. Our work provides important hypotheses on CR parameter selection for future preclinical and clinical studies. [ABSTRACT FROM AUTHOR]

Owing to its versatile roles in almost all aspects of plants, FERONIA (FER), a receptor-like kinase of the Catharanthus roseus receptor-like kinase 1-like (CrRLK1L) subfamily, has received extensive research interests during the past decades. Accumulating evidence has been emerged that FER homologs in horticultural crops also play crucial roles in reproductive biology and responses to environmental stimuli (abiotic and biotic stress factors). Here, we provide a review for the latest advances in the studies on FER homologs in modulating stress responses in horticultural crops, and further analyze the underlying mechanisms maintained by FER. Moreover, we also envisage the missing links in current work and provide a perspective for future studies on this star protein. [ABSTRACT FROM AUTHOR]

Recent advances in the field of human cognition development have led to increased interest in the study of cross-modal correspondence. In the case of the correspondence between sound and shape, the correspondence between simple sound (e.g., pitch, timbre) and shape angularity of has been studied while there has been little research on the other features. Previous studies have shown that the emotion mediates cross-modal correspondences. Therefore, this study focuses on the complexity of tone sequences and shapes, which is said to have more influence on emotion than simple sound or shape angularity, and aims to examine the correspondences mediated by their complexity. First, indices for shape complexity (curvature entropy) and tone sequence complexity (information entropy) are selected. Then, an experiment was conducted to investigate the correspondence between shapes and tone sequences. As a result, the correspondence between the complexity of shapes and tone sequences was found. [ABSTRACT FROM AUTHOR]

Mechanical vibratory stimuli applied to the thoracoabdominal region enhance emotional experiences while watching movies. We hypothesized that these vibrations to the thoracoabdominal region stimulate the vagus nerves, which are distributed in the upper body organs, causing interoceptive sensations that influence emotions. To investigate this hypothesis, we compared the effects of vibratory stimuli on fear between the thoracoabdominal region and fingers, which have the highest tactile sensitivity in the body, while watching horror movies. The results showed that vibratory stimuli to the thoracoabdominal evoked greater subjective evaluations than those to the fingers and conditions without vibratory stimuli. Further, greater skin conductance responses were caused by the stimulation to the thoracoabdominal region than the no vibratory condition. These findings suggest that mechanical vibratory stimuli to the vagus nerve play a crucial role in shaping emotional experiences. [ABSTRACT FROM AUTHOR]

Hydrogels are hydrophilic, three-dimensional, cross-linked polymers that absorb significant amounts of biological fluids or water. Hydrogels possess several favorable properties, including flexibility, stimulus-responsiveness, versatility, and structural composition. They can be categorized according to their sources, synthesis route, response to stimulus, and application. Controlling the cross-link density matrix and the hydrogels' attraction to water while they're swelling makes it easy to change their porous structure, which makes them ideal for drug delivery. Hydrogel in drug delivery can be achieved by various routes involving injectable, oral, buccal, vaginal, ocular, and transdermal administration routes. The hydrogel market is expected to grow from its 2019 valuation of USD 22.1 billion to USD 31.4 billion by 2027. Commercial hydrogels are helpful for various drug delivery applications, such as transdermal patches with controlled release characteristics, stimuli-responsive hydrogels for oral administration, and localized delivery via parenteral means. Here, we are mainly focused on the commercial hydrogel products used for drug delivery based on the described route of administration. [ABSTRACT FROM AUTHOR]

Multipole expansions have been used extensively in the Magnetoencephalography (MEG) literature for mitigating environmental interference and modelling brain signal. However, their application to Optically Pumped Magnetometer (OPM) data is challenging due to the wide variety of existing OPM sensor and array designs. We therefore explore how such multipole models can be adapted to provide stable models of brain signal and interference across OPM systems. Firstly, we demonstrate how prolate spheroidal (rather than spherical) harmonics can provide a compact representation of brain signal when sampling on the scalp surface with as few as 100 channels. We then introduce a type of orthogonal projection incorporating this basis set. The Adaptive Multipole Models (AMM), which provides robust interference rejection across systems, even in the presence of spatially structured nonlinearity errors (shielding factor is the reciprocal of the maximum fractional nonlinearity error). Furthermore, this projection is always stable, as it is an orthogonal projection, and will only ever decrease the white noise in the data. However, for array designs that are suboptimal for spatially separating brain signal and interference, this method can remove brain signal components. We contrast these properties with the more typically used multipole expansion, Signal Space Separation (SSS), which never reduces brain signal amplitude but is less robust to the effect of sensor nonlinearity errors on interference rejection and can increase noise in the data if the system is sub‐optimally designed (as it is an oblique projection). We conclude with an empirical example utilizing AMM to maximize signal to noise ratio (SNR) for the stimulus locked neuronal response to a flickering visual checkerboard in a 128‐channel OPM system and demonstrate up to 40 dB software shielding in real data. [ABSTRACT FROM AUTHOR]

Background: The specific goal was to determine the level and differences in the performance of reactive agility (RA) depending on the type of visual stimulus and to identify the role of selected psychological patterns in the decision-making process. Method: 13 female basketball players (17.12 ± 1.09 years; mean BW 58.17 kg ± 7.68 kg; mean BH 1.73 ± 0.11, BMI 19.53 ± 3.86) playing top Slovak junior league. The diagnosis of specific game reactions was carried out using a Y-shaped reaction agility test. The stimulus for the action effect was a light direction indicator and a video sequence. Decision-making style was assessed using the Melbourne Decision Making Questionnaire (MDMQ). Results: The significance of the differences between offensive actions according to the type of stimulus was revealed by statistically significant differences between offensive reaction agility to a light stimulus and a stimulus with a contextual stimulus, and also in the case of defensive actions. Correlation analysis revealed significant correlations between offensive and defensive skills in the light stimulus, between the performance in offensive skills in the light stimulus, between the two types of defensive agility (light and video) and in the context stimulus, and a correlation between vigilance and both offensive activities was also found. Conclusion: The player's sensorimotor mechanisms are different depending on the type of stimulus, not on the type of actions, which leads to the conclusion that specific contextual information can lead to faster and more accurate decisions during the game 1:1 and improve the timing of action effects. [ABSTRACT FROM AUTHOR]

Reproduction in mammals includes two general categories of behaviors: mating and parenting. Historically and cross-culturally, men invest more than women in mating; women invest more than men in parenting. Sex differences in attention and attitude toward mating and parenting stimuli have rarely been assessed together despite theoretical interest. To evaluate these differences simultaneously in a naturalistic setting, 582 study participants (459 women, 123 men) were presented with sexual and infant images, online in the privacy of their home, at three time periods spanning several weeks for a more reliable result. Attention was measured by covertly recording viewing time of images using Qualtrics software, and attitude was measured via self-report after each viewing session. Men reported a more positive attitude than women toward the sexual images; women reported a more positive attitude than men toward the infant images. Women viewed the infant images marginally longer than did men, and the infant-to-sexual viewing ratio was larger for women. The sexual-to-infant viewing ratio was larger for men than for women. Unexpectedly, both genders viewed the sexual images longer than the infant images, with no significant gender difference in the sexual image viewing time. The results suggest that women and men may give equal attention to visual sexual stimuli despite self-reported sex differences in interest. The possibly underestimated valence of visual sexual stimuli for women is discussed. [ABSTRACT FROM AUTHOR]

Binocular rivalry is an example of bistable visual perception extensively examined in neuroimaging. Magnetoencephalography can track brain responses to phasic visual stimulations of predetermined frequency and phase to advance our understanding of perceptual dominance and suppression in binocular rivalry. We used left and right eye stimuli that flickered at two tagging frequencies to track their respective oscillatory cortical evoked responses. We computed time‐resolved measures of coherence to track brain responses phase locked with stimulus frequencies and with respect to the participants' indications of alternations of visual rivalry they experienced. We compared the brain maps obtained to those from a non‐rivalrous control replay condition that used physically changing stimuli to mimic rivalry. We found stronger coherence within a posterior cortical network of visual areas during rivalry dominance compared with rivalry suppression and replay control. This network extended beyond the primary visual cortex to several retinotopic visual areas. Moreover, network coherence with dominant percepts in primary visual cortex peaked at least 50 ms prior to the suppressed percept nadir, consistent with the escape theory of alternations. Individual alternation rates were correlated with the rate of change in dominant evoked peaks, but not for the slope of response to suppressed percepts. Effective connectivity measures revealed that dominant (respectively, suppressed) percepts were expressed in dorsal (respectively ventral) streams. We thus demonstrate that binocular rivalry dominance and suppression engage distinct mechanisms and brain networks. These findings advance neural models of rivalry and may relate to more general aspects of selection and suppression in natural vision. [ABSTRACT FROM AUTHOR]

Vibratory stimuli to viewers’ upper bodies enhance emotional experiences during audio-visual content. Studies have investigated the effects of stimulation conditions, such as vibration waveform and spatiotemporal patterns. We investigated how the timing of vibratory stimuli affect viewers’ skin conductance responses and subjective reports of audio-visual experiences. Vibratory stimuli were administered to the viewers’ torso at various timings around a monster’s sudden appearance in horror videos, and jump performances in figure skating videos. For horror videos, vibratory stimuli elicited fear. The fear of horror videos was maximized when the vibratory stimuli started simultaneously with the monster’s first appearance. For the jump performance scenes in figure skating videos, although the most exciting timing varied by participant, the vibration should be intensified as performers launch off the ice. These findings will help develop entertaining audio-visual content. [ABSTRACT FROM AUTHOR]

This study aimed to compare the acute physiological responses from hypoxic exposure during intervals between efforts performed in high intensity. Nine healthy men voluntarily participated in this randomized, single-blind design study. Participants completed two training sessions with ten 1-minute efforts in normoxia [oxygen inspired fraction (FiO 2) = 20.9%] at 120% of the peak speed achieved in a graduated exercise test, followed by 2-minute passive recovery with or without hypoxia (FiO 2 = 13.6%). During the sessions, the physiological responses (heart rate (HR), peripheral oxygen saturation (SpO 2), blood lactate), the internal and external exercise loads, the hypoxia dose, and the arterial partial oxygen pressure (PaO 2) were measured. The recorded data were analyzed using a Bayesian statistical approach. There was no difference between normoxia and hypoxia for blood lactate, internal and external loads. SpO 2 and PaO 2 in hypoxia were lower than in normoxia, while HR and dose of hypoxia were higher in hypoxia than in normoxia. These results demonstrate that exposure to hypoxia in the intervals between efforts can be an additional stimulus to training without impairing the external load and the quality of the training sessions. [ABSTRACT FROM AUTHOR]

The regulation of the circadian cycle, an essential process for the functioning of living organisms, including humans, is highly dependent on exposure to external light, directly influencing the sleep cycle. However, increasing exposure to artificial light from digital devices such as televisions, cell phones and computers, especially during nighttime hours, has raised concerns about its impact on the circadian cycle. This prolonged exposure alters external stimuli and, in turn, affects the production of internal chemical messengers, which can lead to metabolic, hormonal, immunological, mental and physical disorders in individuals. These findings underscore the importance of understanding the negative effects of blue light and developing strategies to counteract its impacts on human health and well-being. [ABSTRACT FROM AUTHOR]

Stimuli that evoke emotions are salient, draw attentional resources, and facilitate situationally appropriate behavior in complex or conflicting environments. However, negative and positive emotions may motivate different response strategies. For example, a threatening stimulus might evoke avoidant behavior, whereas a positive stimulus may prompt approaching behavior. Therefore, emotional stimuli might either elicit differential behavioral responses when a conflict arises or simply mark salience. The present study used functional magnetic resonance imaging to investigate valence-specific emotion effects on attentional control in conflict processing by employing an adapted flanker task with neutral, negative, and positive stimuli. Slower responses were observed for incongruent than congruent trials. Neural activity in the dorsal anterior cingulate cortex was associated with conflict processing regardless of emotional stimulus quality. These findings confirm that both negative and positive emotional stimuli mark salience in both low (congruent) and high (incongruent) conflict scenarios. Regardless of the conflict level, emotional stimuli deployed greater attentional resources in goal directed behavior. [ABSTRACT FROM AUTHOR]

Humans can produce "express" (~100 ms) arm muscle responses that are inflexibly locked in time and space to visual target presentations, consistent with subcortical visuomotor transformations via the tecto-reticulo-spinal pathway. These express visuomotor responses are sensitive to explicit cue-driven expectations, but it is unclear at what stage of sensory-to-motor transformation such modulation occurs. Here, we recorded electromyographic activity from shoulder muscles as participants reached toward one of four virtual targets whose physical location was partially predictable from a symbolic cue. In an experiment in which targets could be veridically reached, express responses were inclusive of the biomechanical requirements for reaching the cued locations and not systematically modulated by cue validity. In a second experiment, movements were restricted to the horizontal plane so that the participants could perform only rightward or leftward reaches, irrespective of target position on the vertical axis. Express muscle responses were almost identical for targets that were validly cued in the horizontal direction, regardless of cue validity in the vertical dimension. Together, these findings suggest that the cue-induced enhancements of express responses are dominated by effects at the level of motor plans and not solely via facilitation of early visuospatial target processing. Notably, direct corticotectal and corticoreticular projections exist that are well-placed to modulate prestimulus motor preparation state in subcortical circuits. Our results could reflect a neural mechanism by which contextually relevant motor responses to compatible visual inputs are rapidly released via subcortical circuits that are sufficiently along the sensory-to-motor continuum. [ABSTRACT FROM AUTHOR]

Research findings on which brain areas demonstrate fMRI adaptation to the form, orientation, and size of visual stimuli has been mixed. Studies demonstrate effects in various subdivisions of the lateral occipital complex (LOC), including retinotopically tuned areas LO-1 and LO-2, and dorsal stream areas in the intraparietal sulcus (IPS). Therefore, we aimed to examine fMRI adaptation in four subdivisions of the LOC (LO-proper, posterior fusiform sulcus, LO-1, and LO-2) and three discrete regions in the IPS (caudal IPS, IPS-proper, and anterior IPS) to clarify the role that these structures play in form, orientation, and size processing. Participants performed three tasks which involved judging whether two serially presented novel objects shared the same form, orientation, or size. On each version of the task, one feature varied from trial-to-trial (e.g., form) while the other two features (e.g., orientation and size) were held constant. In this way, we were able to examine the unique fMRI signal changes in response to changes in form, orientation, and size in isolation. Form adaptation - a decrease in fMRI signal following repeated presentation of the same stimulus - was present in LO-proper and pFS, highlighting the role of LOC in form processing. Size repetition enhancement - an increase in fMRI signal following repeated presentations of the same stimulus - was observed in pFs. We propose that the latter result demonstrates the effects that top-down factors can have on visual areas, specifically when there is stimulus uncertainty. There was no evidence of orientation processing in any of the regions examined. Neither form adaptation nor size repetition enhancement was present in the three IPS regions-of-interest. Last, retinotopically defined LO1 and LO2 could not be reliably identified in participants and therefore we were unable to examine adaptation in these areas as we originally intended to do. [ABSTRACT FROM AUTHOR]

Adapting to novelty is essential for an organism's survival in an uncertain world. Neuroimaging evidence consistently links the anterior prefrontal, specifically the frontopolar cortex (FPC; BA10), to exploratory reweighting of attentional weights thereby underscoring the role of the FPC in responding to environmental changes that are often complex and may occur very rapidly. Here we report new evidence showing that the FPC serves a role in attentional reallocation even in the absence of conscious awareness. Both mass-univariate and multivariate pattern analyses of fMRI data revealed that the right FPC and other attention-related areas not only are sensitive to unaware changes in the relevant stimulus dimension, but also that unconsciously processed information of the novel stimulus was globally represented across these regions. Our results indicate that unconsciously processed information can reach a global level of representation outside the occipitotemporal cortex, and that the FPC is crucial for the reweighting of selection biases in the absence of visual awareness. [ABSTRACT FROM AUTHOR]

Language production involves a complex set of computations, from conceptualization to articulation, which are thought to engage cascading neural events in the language network. However, recent neuromagnetic evidence suggests simultaneous meaning-to-speech mapping in picture naming tasks, as indexed by early parallel activation of frontotemporal regions to lexical semantic, phonological, and articulatory information. Here we investigate the time course of word production, asking to what extent such "earliness" is a distinctive property of the associated spatiotemporal dynamics. Using MEG, we recorded the neural signals of 34 human subjects (26 males) overtly naming 134 images from four semantic object categories (animals, foods, tools, clothes). Within each category, we covaried word length, as quantified by the number of syllables contained in a word, and phonological neighborhood density to target lexical and post-lexical phonological/phonetic processes. Multivariate pattern analyses searchlights in sensor space distinguished the stimulus-locked spatiotemporal responses to object categories early on, from 150 to 250 ms after picture onset, whereas word length was decoded in left frontotemporal sensors at 250-350 ms, followed by the latency of phonological neighborhood density (350-450 ms). Our results suggest a progression of neural activity from posterior to anterior language regions for the semantic and phonological/phonetic computations preparing overt speech, thus supporting serial cascading models of word production. [ABSTRACT FROM AUTHOR]

Background: Mitochondria have an essential role in regulating metabolism and integrate environmental and physiological signals to affect processes such as cellular bioenergetics and response to stress. In the metabolically active skeletal muscle, mitochondrial biogenesis is one important component contributing to a broad set of mitochondrial adaptations occurring in response to signals, which converge on the biogenesis transcriptional regulator peroxisome proliferator-activated receptor coactivator 1-alpha (PGC-1α), and is central to the beneficial effects of exercise in skeletal muscle. We investigated the role of long non-coding RNA (lncRNA) taurine-upregulated gene 1 (TUG1), which interacts with PGC-1α in regulating transcriptional responses to exercise in skeletal muscle. Results: In human skeletal muscle, TUG1 gene expression was upregulated post-exercise and was also positively correlated with the increase in PGC-1α gene expression (PPARGC1A). Tug1 knockdown (KD) in differentiating mouse myotubes led to decreased Ppargc1a gene expression, impaired mitochondrial respiration and morphology, and enhanced myosin heavy chain slow isoform protein expression. In response to a Ca2+-mediated stimulus, Tug1 KD prevented an increase in Ppargc1a expression. RNA sequencing revealed that Tug1 KD impacted mitochondrial Ca2+ transport genes and several downstream PGC-1α targets. Finally, Tug1 KD modulated the expression of ~300 genes that were upregulated in response to an in vitro model of exercise in myotubes, including genes involved in regulating myogenesis. Conclusions: We found that TUG1 is upregulated in human skeletal muscle after a single session of exercise, and mechanistically, Tug1 regulates transcriptional networks associated with mitochondrial calcium handling, muscle differentiation and myogenesis. These data demonstrate that lncRNA Tug1 exerts regulation over fundamental aspects of skeletal muscle biology and response to exercise stimuli. [ABSTRACT FROM AUTHOR]

H-reflex depression (diminution of amplitude after a conditioning stimulus) is mediated presynaptically and therefore can help distinguish central versus peripheral mechanisms of fatigue. We examined the effects of a dynamic exercise protocol on H-reflex depression using two conditioning methods: homonymous conditioning (paired-pulse tibial nerve stimulation); and heteronymous conditioning (common peroneal nerve stimulation). Ten subjects performed dynamic contractions of the soleus muscle through 30° ankle range of motion. The concentric phase required a target force of 10% of maximum voluntary isometric contraction (MVIC) and the eccentric phase force target was 80% MVIC. Fatigue persisted for >20 min after cessation of the exercise. Compared with prefatigue values, the dynamic fatigue protocol did not increase presynaptic inhibition after either homonymous or heteronymous conditioning. Peak to peak amplitude of unconditioned H-reflexes was likewise unchanged despite a long term depression of muscle force (long duration fatigue). These results suggest that persistent fatigue after dynamic exercise is attributed to muscle changes and not altered spinal mechanisms. [ABSTRACT FROM AUTHOR]

Motor function and weight status are components of physical fitness that have been implicated in childhood motor and cognitive development. The lateralized readiness potential (LRP), an index of motor planning and action, can provide context surrounding relationships between fitness and brain activity underlying cognitive and motor functions. This study evaluated the relationship between the LRP and motor skills, as well as associations between weight status and neural and behavioral motor functions. Children aged 7–13 (n = 35) participated in a cross-sectional study, using the Movement Assessment Battery for Children 2nd edition (MABC-2) to assess balance, manual dexterity, and aiming/catching. The stimulus- (LRP-S) and response-locked (LRP-R) LRPs were elicited from a modified flanker task. Stepwise regressions tested the association between LRPs and MABC-2 components. Linear regressions were conducted to examine BMI and %Fat in relation to LRPs and MABC-2 components. Analyses revealed that LRP-S mean amplitude difference (β = 0.401, P = 0.042) and reaction time interference scores (β = 0.545, P = 0.004) were positively associated with balance, after adjusting for covariates. The LRP-S and interference scores did not predict other MABC-2 outcomes and LRP-R did not predict any MABC-2 components. Further, %Fat (β = −0.439, P = 0.044), not BMI (β = −0.364, P = 0.082), only predicted balance. We found that changes in the LRP-S amplitude were positively associated with balance, and %Fat was negatively related to balance. This evidence is that fitness components such as weight status and coordination are related to neural markers of motor function which may be useful in intervention designs aimed to improve brain function via improvements in physical fitness and health behaviors. • Event related potentials have been associated with physical fitness in children. • The lateralized readiness potential (LRP) has not been linked to coordination. • The LRP was positively related to balance and no other coordination skills. • Only balance and no other skill was related to body fat not body mass index. [ABSTRACT FROM AUTHOR]

Maintaining focus of attention over prolonged periods can be challenging, especially when the target stimulus is absent from the temporal sequence. Prior research has shown that a temporal attentional cue filling in the temporal blank can improve sustained attention: in a sustained visual attention task requiring synchronizing finger tapping with a temporally regular sequence composed of brief flash disks interleaved with blank periods, task performance was improved when a continuous fixation point that served as a temporal attentional cue was presented superimposed on the disk stimulus. To test the hypothesis that binding the temporal attentional cue with the target temporal sequence by spatial overlapping is crucial for enhancing sustained attention, the present study conducted a series of three experiments that deconstructed the bound connection between the cue and the sequence stimulus. In Experiment 1, the cue was placed above or below a flash disk. In Experiment 2, the cue was between two vertically arranged flash disks. In Experiment 3, the cue was in a flash ring. No significant effect of sustained attention improvement was found in any of the three experiments. Experiment 4 further replicated these null results and the previously observed effect of sustained attention improvement when the temporal cue was superimposed on the sequence stimulus. Our finding demonstrates that binding by spatial overlapping during the temporal blank when the sequence stimulus is absent is critical for enhancing sustained attention, which should be beneficial for improving performance across a broader range of tasks that require prolonged maintenance of attention. [ABSTRACT FROM AUTHOR]

The placebo effect of caffeine has been poorly investigated in endurance exercise. Therefore, the aim of this study was to analyze the placebo effect of caffeine on 4 km running performance in amateur runners. Twenty-two healthy and recreational male runners (25.5 ± 8.4 yrs; 75.0 ± 7.1 kg; 173.7 ± 6.3 cm) underwent a deceptive experimental design consisting of three different sessions: a) control (CON) in which participants did not ingest any substance; b) placebo (PLA) in which participants ingested a capsule filled with maltodextrin but they were informed that they would receive caffeine; c) caffeine (CAF) in which participants were informed that they would receive caffeine and actually received caffeine. After 60 min for substances absorption, participants performed a 4-km test and they completed the distance as fast as possible. The time employed to cover the distance was lower in PLA (17.4 ± 1.5 min) and CAF (17.4 ± 1.4 min) than CON sessions (18.6 ± 2.8 min; P<0.05). There were no differences in the 4-km times between PLA and CAF (P>0.05) and no differences were reported between treatments for RPE (P>0.05). In conclusion, there was a placebo effect of caffeine on a 4-km maximal running trial which entailed that believing to have ingested caffeine improved performance to a similar extent than actually receiving caffeine. Therefore, the expectancy induced by caffeine may be one of the mechanisms behinds the ergogenic effect of this stimulant on endurance exercise. [ABSTRACT FROM AUTHOR]

This study was conducted of traffic noise which affected on urban traffic noise of selected roadside school as acoustic comfort for selected locations (near school buildings) of Burdwan town and the ambient noise was recorded during four different time periods (early morning, late morning, afternoon and evening). Geographical Information System (GIS) based Inverse distance weighting (IDW) interpolating technique was used to identify the vulnerability of noise pollution in mixed areas of schools. The different acoustic descriptor such as Leq, L90, L50, LIO, noise climate (NC), traffic noise index (TNI) and noise pollution level (NPL) were evaluated, while a community study was also simultaneously conducted. The results revealed that the average Leq, L90, L50, LIO varied from 76.5 dB (A) to 78.6 dB (A), 58.2 dB (A) to 60 dB (A), 65.6 (A) to 67.3 dB (A) and 86.6 (A) to 94.5 dB (A), respectively. It was observed that the noise climate reached its peak in the afternoon (35.7 ± dB (A)) and was the lowest in the evening (27.8 ± dB (A)). The health data indicated that about 71% and 8% of the inhabitants near the schools were suffering from irritation and sleeping problems respectively. The similar correlation study revealed that Leq (r = 0.484, p < 0.679), L90 (r = 0.871, p < 0.327), and L50 (r = 0.507, p < 0.662) were strongly correlated with sleep disturbance. It may therefore be safely concluded that school children in the subject schools being exposed to the same levels of hazard as the residents in the immediate vicinity were probably suffering from similar problems. [ABSTRACT FROM AUTHOR]

In the present study, we assessed functional response curves of two generalist coccinellid beetles (Coleoptera: Coccinellidae), specifically Menochilus sexmaculatus and Propylea dissecta, using fluctuating densities of aphid prey as a stimulus. In what may be the first such study, we investigated how the prey density experienced during the early larval development of these two predatory beetle species shaped the functional response curves of the late instar–larval and adult stages. The predators were switched from their rearing prey-density environments of scarce, optimal, or abundant prey to five testing density environments of extremely scarce, scarce, suboptimal, optimal, or abundant prey. The individuals of M. sexmaculatus that were reared on either scarce- and optimal- or abundant-prey densities exhibited type II functional response curves as both larvae and adults. However, individuals of P. dissecta that were reared on scarce- and abundant-prey densities displayed modified type II functional response curves as larvae and type II functional response curves as adults. In contrast, individuals of P. dissecta reared on the optimal-prey density displayed type II functional response curves as larvae and modified type II functional response curves as adults. The fourth-instar larvae and adult females of M. sexmaculatus and P. dissecta also exhibited highest prey consumption (T/Th) and shortest prey-handling time (Th) on the scarce-prey rearing density. Thus, under fluctuating-prey conditions, M. sexmaculatus is a better biological control agent of aphids than P. dissecta is. [ABSTRACT FROM AUTHOR]

Polarity-dependent orientation illusions are manifested in figures in which the impression of target orientation does not depend only on geometrical relations between the elements of the figure, but also on the relations between their luminances, that is, on luminance polarities. The best-known phenomenon belonging to this class of effects is the Münsterberg/Café Wall illusion. In this paper a considerable number of examples of this type of illusions are presented, many of which are novel variants. A two-level convolutional model of such illusions is introduced, in which the first level corresponds to the stimulus input and the second level contains units fashioned after simple cells in V1, whose spatial patterns of activity represent the model's reaction to the stimulus. The main finding of numerous simulations of the model is that the figures inducing illusory impressions of tilt share a common spatial pattern of neural activation, labeled 'oblique clusters', which is absent in related non-illusory figures. Furthermore, a similar pattern is also present in simulations of figures which induce veridical impressions of tilt. The simulations suggest that the neural basis of perception of a specific degree of tilt may not be the activity of neurons tuned narrowly to that particular degree of tilt, but rather the presence of certain signature spatial patterns of activity of populations of neurons. [ABSTRACT FROM AUTHOR]

Complex regional pain syndrome (CRPS) is still poorly understood. It is a pain disorder in which pain is disproportionate to the initial stimulus. There is no specific therapy for CRPS, but it can be managed by a combination of treatments. We report a 13-year-old girl with CRPS of the upper limb treated with somatic and abdominal acupuncture. She described a severe, pulsating pain in the left wrist and hand, with hypersensitivity, allodynia, a marked reduction in strength, and swelling and sweating at the level of the fingers. Pain began three months previously, after a trauma to the left wrist. The diagnostic tests performed were negative. At the first visit we recommended oral tramadol. During the first two sessions we used somatic acupuncture. At the third session, the girl reported suffering intolerable pain in the affected limb during the previous sessions, so we decided to use abdominal acupuncture. After 8 sessions of abdominal acupuncture the pain completely disappeared. Acupuncture could be a potential alternative when conservative therapy with physical and medical treatment fails, but more often parents and adolescents prefer this therapy since other comorbidities are often present in pediatric populations and abdominal acupuncture could be a valuable alternative aid. [ABSTRACT FROM AUTHOR]

Stereotyped vocal behavior exhibited by a seven-year-old child diagnosed with autism spectrum disorder and maintained by automatic reinforcement was placed under stimulus control through discrimination training. The training consisted of matching a green card (SD) with free access to vocal stereotypy and a red card (SD-absent) with interruption of stereotypy and vocal redirection. At the same time, appropriate behaviors were reinforced. After discrimination training, the child rarely engaged in vocal stereotypy in the red card condition and, to a greater extent, in the green card condition, demonstrating the ability to discriminate between the two different situations. After the training, the intervention began. Once they reached the latency criterion in the red stimulus condition, the child could have free access to vocal stereotypy (green card condition). The latency criterion for engaging in stereotypy was gradually increased during the red card condition and progressively decreased during the green card condition. The intervention follows a changing criterion design. This study indicates that stimulus discrimination training is a useful intervention to reduce vocal stereotypy in an autistic child. [ABSTRACT FROM AUTHOR]

Noise and high light illumination in the neonatal intensive care unit (NICU) are recognized as stressors that could alter the well-being and development of vulnerable preterm infants. This prospective observational study evaluated the pain behaviours of very preterm infants (VPIs) to sound peaks (SPs) and light levels variations (LLVs) in the NICU. We measured spontaneously occurring SPs and LLVs in the incubators of 26 VPIs over 10 h. Their behavioural responses were analysed through video recordings using the “Douleur Aigue du Nouveau-né” (DAN) scale. We compared the maximum DAN scores before and after environmental stimuli and the percentage of VPIs with a score ≥ 3 according to the type of stimuli. A total of 591 SPs and 278 LLVs were analysed. SPs of 5 to 15 dBA and LLVs significantly increased the maximum DAN scores compared to baseline. The occurrence of DAN scores ≥ 3 increased with both stressors, with a total of 16% of SPs and 8% of LLVs leading to quantifiable pain behaviour. Altogether, this study shows that VPIs are sensitive to SPs and LLVs, with a slighter higher sensitivity to SPs. The mechanisms leading to pain behaviours induced by noise and light changes should be evaluated further in the context of VPIs brain development. Our results provide further arguments to optimize the NICU sensory environment of neonatal units and to adapt it to the expectations and sensory abilities of VPIs. [ABSTRACT FROM AUTHOR]

Human cerebral cortex can produce visuomotor responses that are modulated by contextual and task-specific constraints. However, the distributed cortical network for visuomotor transformations limits the minimal response time of that pathway. Notably, humans can generate express visuomotor responses in arm muscles that are inflexibly tuned to the target location and occur 80–120 ms from stimulus presentation [stimulus-locked responses (SLRs)]. This suggests a subcortical pathway for visuomotor transformations that might involve the superior colliculus and its downstream reticulo-spinal projections. Here we investigated whether cognitive expectations can modulate the SLR. In one experiment, we recorded surface electromyogram (EMG) from shoulder muscles as participants reached toward a visual target whose location was unpredictable in control conditions and partially predictable in cue conditions by interpreting a symbolic cue (75% validity). Valid symbolic cues led to earlier and larger SLRs than control conditions; invalid symbolic cues produced later and smaller SLRs than control conditions. This is consistent with a cortical top-down modulation of the putative subcortical SLR network. In a second experiment, we presented high-contrast targets in isolation (control) or ~24 ms after low-contrast stimuli, which could appear at the same (valid cue) or opposite (invalid cue) location as the target and with equal probability (50% cue validity). We observed earlier SLRs than control with the valid low-contrast cues, whereas the invalid cues led to the opposite results. These findings may reflect bottom-up attentional mechanisms, potentially evolving subcortically via the superior colliculus. Overall, our results support both top-down and bottom-up modulations of the putative subcortical SLR network in humans. [ABSTRACT FROM AUTHOR]

Smeets et al. (2016) suggested that motor adjustments may be quick because they don't require stimulus detection. We agree that these rapid adjustments probably reflect rapid perceptual processing rather than rapid motor execution, but we question whether the absence of detection is the best way to explain the effect. We suggest that it is unclear what mechanisms would be involved in detection and why detection would be required in some of the cases discussed by Smeets et al. Instead, we suggest that ultra-fast motor adjustments require very little competition among possible stimuli or responses. We suggest that escaping competition rather than avoiding detection may be the cause of the very short reaction times that Smeets et al. identified. [ABSTRACT FROM AUTHOR]

We can adjust an ongoing movement to a change in the target's position with a latency of about 100 ms, about half of the time that is needed to start a new movement in response to the same change in target position (reaction time). In this opinion paper, we discuss factors that could explain the difference in latency between initiating and adjusting a movement in response to target displacements. We consider the latency to be the sum of the durations of various stages in information processing. Many of these stages are identical for adjusting and initiating a movement; however, for movement initiation, it is essential to detect that something has changed to respond, whereas adjustments to movements can be based on updated position information without detecting that the position has changed. This explanation for the shorter latency for movement adjustments also explains why we can respond to changes that we do not detect. [ABSTRACT FROM AUTHOR]

When stimulus inputs from different senses are integrated to form a coherent percept, inputs from a more precise sense are typically more dominant than those from a less precise sense. Furthermore, we hypothesized that some basic stimulus features, such as orientation, can be supramodal-represented at a conceptual level that is independent of the original modality precision. This hypothesis was tested with perceptual learning experiments. Specifically, participants practiced coarser tactile orientation discrimination, which initially had little impact on finer visual orientation discrimination (tactile vs. visual orientation thresholds = 3:1). However, if participants also practiced a functionally orthogonal visual contrast discrimination task in a double training design, their visual orientation performance was improved at both tactile-trained and untrained orientations, as much as through direct visual orientation training. The complete tactile-to-visual learning transfer is consistent with a conceptual supramodal representation of orientation unconstrained by original modality precision, likely through certain forms of input standardization. Moreover, this conceptual supramodal representation, when improved through perceptual learning in one sense, can in turn facilitate orientation discrimination in an untrained sense. [ABSTRACT FROM AUTHOR]

The ability to distinguish self-generated stimuli from those caused by external sources is critical for all behaving organisms. Although many studies point to a sensory attenuation of self-generated stimuli, recent evidence suggests that motor actions can result in either attenuated or enhanced perceptual processing depending on the environmental context (i.e., stimulus intensity). The present study employed 2-AFC sound detection and loudness discrimination tasks to test whether sound source (self- or externally-generated) and stimulus intensity (supra- or near-threshold) interactively modulate detection ability and loudness perception. Self-generation did not affect detection and discrimination sensitivity (i.e., detection thresholds and Just Noticeable Difference, respectively). However, in the discrimination task, we observed a significant interaction between self-generation and intensity on perceptual bias (i.e. Point of Subjective Equality). Supra-threshold self-generated sounds were perceived softer than externally-generated ones, while at near-threshold intensities self-generated sounds were perceived louder than externally-generated ones. Our findings provide empirical support to recent theories on how predictions and signal intensity modulate perceptual processing, pointing to interactive effects of intensity and self-generation that seem to be driven by a biased estimate of perceived loudness, rather by changes in detection and discrimination sensitivity. [ABSTRACT FROM AUTHOR]

How information in the nervous system is encoded by patterns of action potentials (i.e. spikes) remains an open question. Multi-neuron patterns of single spikes are a prime candidate for spike time encoding but their temporal variability requires further characterisation. Here we show how known sources of spike count variability affect stimulus-evoked spike time patterns between neurons separated over multiple layers and columns of adult rat somatosensory cortex in vivo. On subsets of trials (clusters) and after controlling for stimulus-response adaptation, spike time differences between pairs of neurons are "time-warped" (compressed/stretched) by trial-to-trial changes in shared excitability, explaining why fixed spike time patterns and noise correlations are seldom reported. We show that predicted cortical state is correlated between groups of 4 neurons, introducing the possibility of spike time pattern modulation by population-wide trial-to-trial changes in excitability (i.e. cortical state). Under the assumption of state-dependent coding, we propose an improved potential encoding capacity. [ABSTRACT FROM AUTHOR]

Previous research work suggests that predictable target motion such as sinusoidal movement can be anticipated by the visual system, thereby improving the accommodative response. The validity of predictable motion for studying human dynamic accommodation is sometimes put into question. The aim of this work was to assess the effect of anticipation along with learning (and motivation, etc.) and fatigue (and boredom, loss of attention, etc.) on dynamic accommodation experiments from a practical perspective. Specifically, changes in amplitude and temporal phase lag were estimated within and between trials as 9 adult observers were instructed to focus on a stimulus that oscillated sinusoidally towards and away from the eye at specific temporal frequencies. On average, amplitude decreased whereas phase increased within trials. No evidence of anticipation or learning was observed either within or between trials. Fatigue consistently dominated anticipation and learning within the course of each trial. Even if the eye is equipped by a prediction operator as it is often assumed, fatigue confounds the results from dynamic accommodation experiments more than anticipation or learning. [ABSTRACT FROM AUTHOR]

Emotional reactions to movies are typically similar between people. However, depressive symptoms decrease synchrony in brain responses. Less is known about the effect of depressive symptoms on intersubject synchrony in conscious stimulus-related processing. In this study, we presented amusing, sad and fearful movie clips to dysphoric individuals (those with elevated depressive symptoms) and control participants to dynamically rate the clips' valences (positive vs. negative). We analysed both the valence ratings' mean values and intersubject correlation (ISC). We used electrodermal activity (EDA) to complement the measurement in a separate session. There were no group differences in either the EDA or mean valence rating values for each movie type. As expected, the valence ratings' ISC was lower in the dysphoric than the control group, specifically for the sad movie clips. In addition, there was a negative relationship between the valence ratings' ISC and depressive symptoms for sad movie clips in the full sample. The results are discussed in the context of the negative attentional bias in depression. The findings extend previous brain activity results of ISC by showing that depressive symptoms also increase variance in conscious ratings of valence of stimuli in a mood-congruent manner. [ABSTRACT FROM AUTHOR]

Studies on low-level visual information underlying pain categorization have led to inconsistent findings. Some show an advantage for low spatial frequency information (SFs) and others a preponderance of mid SFs. This study aims to clarify this gap in knowledge since these results have different theoretical and practical implications, such as how far away an observer can be in order to categorize pain. This study addresses this question by using two complementary methods: a data-driven method without a priori expectations about the most useful SFs for pain recognition and a more ecological method that simulates the distance of stimuli presentation. We reveal a broad range of important SFs for pain recognition starting from low to relatively high SFs and showed that performance is optimal in a short to medium distance (1.2–4.8 m) but declines significantly when mid SFs are no longer available. This study reconciles previous results that show an advantage of LSFs over HSFs when using arbitrary cutoffs, but above all reveal the prominent role of mid-SFs for pain recognition across two complementary experimental tasks. [ABSTRACT FROM AUTHOR]