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3,069 results on '"SRIVASTAVA, ALOK"'

10. International recommendations for screening and preventative practices for long-term survivors of transplantation and cellular therapy: a 2023 update

Author

Rotz, Seth J., Bhatt, Neel S., Hamilton, Betty K., Duncan, Christine, Aljurf, Mahmoud, Atsuta, Yoshiko, Beebe, Kristen, Buchbinder, David, Burkhard, Peggy, Carpenter, Paul A., Chaudhri, Naeem, Elemary, Mohamed, Elsawy, Mahmoud, Guilcher, Gregory M. T., Hamad, Nada, Karduss, Amado, Peric, Zinaida, Purtill, Duncan, Rizzo, Douglas, Rodrigues, Morgani, Ostriz, Maria Belén Rosales, Salooja, Nina, Schoemans, Helene, Seber, Adriana, Sharma, Akshay, Srivastava, Alok, Stewart, Susan K., Baker, K. Scott, Majhail, Navneet S., and Phelan, Rachel

Published
2024
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11. A review on polylactic acid-based blends/composites and the role of compatibilizers in biomedical engineering applications

Author

Srivastava, Alok, Bhati, Pooja, Singh, Shweta, Agrawal, Mohit, Kumari, Nisha, Vashisth, Priya, Chauhan, Pankaj, and Bhatnagar, Naresh

Subjects
Drugs -- Vehicles, Tissue engineering -- Technology application, Inflammation -- Technology application, Lactic acid -- Technology application, Drug delivery systems -- Technology application, Biopolymers -- Technology application, Technology application, Engineering and manufacturing industries, Science and technology
Abstract

Poly(lactic acid) (PLA) is one of the most promising biopolymers extensively used in food, packaging, medical and pharmaceutical industries. It is due to favorable physicochemical properties, in-situ hydrolytic degradation and well-established processing parameters. However, in medical engineering applications, PLA shows some drawbacks like low cell adhesion, biological inertness, slow degradation rate and high acid inflammation. These shortcomings of pure PLA could be addressed by blending it with other bioresorbable materials and compatibilizers. This review provides comprehensive information on different PLA composites in the field of tissue engineering, implants, injury management and drug delivery systems. The PLA-based composites are divided into four parts: PLA/polymer, PLA/metal, PLA/ceramic, and PLA/nanoparticles. It also investigates various synthesis process, role of different compatibilizers, in vitro studies and their in vivo applications. Highlights * Review the trends of bioresorbable PLA blends/composites. * Extensively focused on PLA blend with polymer, metal, ceramic, and nanoparticles. * Role of reinforcement and compatibilizer to overcome shortcomings of PLA implant. * Highlights advantages, limitations, and properties of different types of PLA implants. * Discuss various clinical applications and future of PLA blends/composite scaffolds. KEYWORDS biomaterial, compatibilizer, PLA composite, PLA implants, PLA nanoparticles, 1 | INTRODUCTION A wide range of bioresorbable polymeric materials (BPM) has been investigated for biomedical engineering applications. The major advantage of BPM is to eliminate the need for a [...]

Published
2024
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14. Biomarkers of coagulation, endothelial, platelet function, and fibrinolysis in patients with COVID-19: a prospective study

Author

S.B., Manoj Job, Chacko, Binila, Selvarajan, Sushil, Peter, John Victor, Geevar, Tulasi, Dave, Rutvi Gautam, Georgy, Josh Thomas, Zachariah, Anand, George, Tina, Sathyendra, Sowmya, Hansdak, Samuel George, Krishnaswami, Rajiv Karthik, Thangakunam, Balamugesh, Gupta, Richa, Karuppusami, Reka, Nair, Sukesh Chandran, and Srivastava, Alok

Published
2024
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16. Relapse and transformation to myelodysplastic syndrome and acute myeloid leukemia following immunosuppressive therapy for aplastic anemia is more common as compared to allogeneic stem cell transplantation with a negative impact on survival

Author

Chattopadhyay, Sohini, Lionel, Sharon, Selvarajan, Sushil, Devasia, Anup J., Korula, Anu, Kulkarni, Uday, Aboobacker, Fouzia N., Lakshmi, Kavitha M., Srivastava, Alok, Mathews, Vikram, Abraham, Aby, and George, Biju

Published
2024
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19. Review of Adequacy of Safeguards and Mitigation of Hazards Through Hazard and Operability (HAZOP) Study

Author

Singh, Garima, Padmavathi, G. L. N., Nagaraju, G., Srivastava, Alok, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Haddar, Mohamed, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Kwon, Young W., Editorial Board Member, Tolio, Tullio A. M., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Schmitt, Robert, Editorial Board Member, Xu, Jinyang, Editorial Board Member, Varde, Prabhakar V., editor, Vinod, Gopika, editor, and Joshi, N. S., editor

Published
2024
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20. Applications of Root Cause Analysis Method in the Domain of Industrial Safety

Author

Padmavathi, G. L. N., Singh, Garima, Nagaraju, G., Srivastava, Alok, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Haddar, Mohamed, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Kwon, Young W., Editorial Board Member, Tolio, Tullio A. M., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Schmitt, Robert, Editorial Board Member, Xu, Jinyang, Editorial Board Member, Varde, Prabhakar V., editor, Vinod, Gopika, editor, and Joshi, N. S., editor

Published
2024
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22. 0D, 1D, 2D & 3D Nano Materials: Synthesis and Applications

Author

Roy, Debmalya, Srivastava, Alok Kr., Mukhopadhyay, Kingsuk, Namburi, Eswara Prasad, Mudali, U. Kamachi, Series Editor, Basu, Bikramjit, Editorial Board Member, Mishra, Suman K., Editorial Board Member, Prasad, N. Eswara, Editorial Board Member, Narayana Murty, S.V.S., Editorial Board Member, Singh, R.N., Editorial Board Member, Balamuralikrishnan, R., Editorial Board Member, Namburi, Eswara Prasad, editor, Wanhill, R. J. H., editor, and Setua, Dipak Kumar, editor

Published
2024
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24. Fabrication and characterization of PLLA/PCL/Mg-Zn-Y alloy composite stent

Author

Srivastava, Alok, Singh, Shweta, Agrawal, Mohit, Bhati, Pooja, Kumari, Nisha, Pandya, Madhur, Vashisth, Priya, Chauhan, Pankaj, and Bhatnagar, Naresh

Subjects
Stent (Surgery) -- Design and construction -- Materials, Alloys -- Usage -- Chemical properties, Polymers -- Usage -- Chemical properties, Engineering and manufacturing industries, Science and technology
Abstract

Bioresorbable polymeric stents (BPS) can become a promising alternative over permanent stents, as it reduce in-stent thrombosis, endothelial dysfunction, and thrombogenicity. Although, a few limitations like uncontrolled degradation, inadequate strength, and lack of radiopacity restrict its application. Thus, a novel bioresorbable radiopaque Mg-Zn-Y Alloy (BRM) of high effective atomic number ([Z.sub.eff]) was developed to reinforce and attenuate X-rays in the polymers. After that, the optimized BRM microparticles were blended with radiolucent poly (L-lactide)/poly ([epsilon]-caprolactone) (PLLA/PCL) polymer and extruded into biaxially expanded (BAE) tubes. Further, in this work, BAE tubes of PLLA/PCL/ BRM and PLLA/PCL were cut using the optimized Femtosecond laser machine (FSLM) parameters for fabricating cardiovascular stents. These stent materials were assessed to sustain the angioplasty procedure, such as radial strength, crimping, recoil, expansion process, and performance under cycling loading. Highlights * A novel biodegradable radiopaque Mg-Zn-Y alloy was developed. * Adding Mg alloy (5% wt.) in PLLA/PCL imparts X-ray visibility. * Composite stents show better compressive radial strength and flexibility. * It also reveals low crimping recoil, expansion recoil, and foreshortening. * Composite stents can withstand arterial vasomotion better than PLLA/PCL. KEYWORDS Biopolymer, Bioresorbable polymer, Composite stents, Crimping, Radiopacity, Recoil, 1 | INTRODUCTION Today, metallic stents are preferred due to their high impact strength, wear resistance, ductility, and toughness. (1) It demonstrates a high success rate in Percutaneous Coronary Intervention [...]

Published
2024
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29. Precise correction of a spectrum of β-thalassemia mutations in coding and non-coding regions by base editors

Author

Prasad, Kirti, Devaraju, Nivedhitha, George, Anila, Ravi, Nithin Sam, Paul, Joshua, Mahalingam, Gokulnath, Rajendiran, Vignesh, Panigrahi, Lokesh, Venkatesan, Vigneshwaran, Lakhotiya, Kartik, Periyasami, Yogapriya, Pai, Aswin Anand, Nakamura, Yukio, Kurita, Ryo, Balasubramanian, Poonkuzhali, Thangavel, Saravanabhavan, Velayudhan, Shaji R., Newby, Gregory A., Marepally, Srujan, Srivastava, Alok, and Mohankumar, Kumarasamypet M.

Published
2024
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30. The role of registries in hematological disorders

Author

Baldomero, Helen, Neumann, Daniel, Hamad, Nada, Atsuta, Yoshiko, Sureda, Anna, Iida, Minako, Karduss, Amado, Elhaddad, Alaa M., Bazuaye, Nosa G., Bonfim, Carmem, Camara, Rafael de la, Chaudhri, Naeem A., Ciceri, Fabio, Correa, Cinthya, Frutos, Cristobal, Galeano, Sebastian, Garderet, Laurent, Greco, Raffaella, Jaimovich, Gregorio, Kodera, Yoshihisa, Koh, Mickey BC., Liu, Kaiyan, Ljungman, Per, McLornan, Donal P., Nair, Gayathri, Okamoto, Shinichiro, Pasquini, Marcelo C., Passweg, Jacob, Paulson, Kristjan, Ruggeri, Annalisa, Seber, Adriana, Snowden, John A., Srivastava, Alok, Worel, Nina, Saber, Wael, Rondelli, Damiano, Aljurf, Mahmoud, and Niederwieser, Dietger

Published
2024
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32. SMART-lipid nanoparticles enabled mRNA vaccine elicits cross-reactive humoral responses against the omicron sub-variants

Author

Mahalingam, Gokulnath, Rachamalla, Hari Krishnareddy, Arjunan, Porkizhi, Karuppusamy, Karthik V., Periyasami, Yogapriya, Mohan, Aruna, Subramaniyam, Kanimozhi, M, Salma, Rajendran, Vigneshwar, Moorthy, Mahesh, Varghese, George M., Mohankumar, Kumarasamypet M., Thangavel, Saravanabhavan, Srivastava, Alok, and Marepally, Srujan

Published
2024
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41. Base editing of key residues in the BCL11A-XL-specific zinc finger domains derepresses fetal globin expression

Author

Rajendiran, Vignesh, Devaraju, Nivedhitha, Haddad, Mahdi, Ravi, Nithin Sam, Panigrahi, Lokesh, Paul, Joshua, Gopalakrishnan, Chandrasekar, Wyman, Stacia, Ariudainambi, Keerthiga, Mahalingam, Gokulnath, Periyasami, Yogapriya, Prasad, Kirti, George, Anila, Sukumaran, Dhiyaneshwaran, Gopinathan, Sandhiya, Pai, Aswin Anand, Nakamura, Yukio, Balasubramanian, Poonkuzhali, Ramalingam, Rajasekaran, Thangavel, Saravanabhavan, Velayudhan, Shaji R., Corn, Jacob E., Mackay, Joel P., Marepally, Srujan, Srivastava, Alok, Crossley, Merlin, and Mohankumar, Kumarasamypet M.

Published
2024
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42. Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin

Author

Ravi, Nithin Sam, Wienert, Beeke, Wyman, Stacia K, Bell, Henry William, George, Anila, Mahalingam, Gokulnath, Vu, Jonathan T, Prasad, Kirti, Bandlamudi, Bhanu Prasad, Devaraju, Nivedhitha, Rajendiran, Vignesh, Syedbasha, Nazar, Pai, Aswin Anand, Nakamura, Yukio, Kurita, Ryo, Narayanasamy, Muthuraman, Balasubramanian, Poonkuzhali, Thangavel, Saravanabhavan, Marepally, Srujan, Velayudhan, Shaji R, Srivastava, Alok, DeWitt, Mark A, Crossley, Merlin, Corn, Jacob E, and Mohankumar, Kumarasamypet M

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Hematology, Rare Diseases, Sickle Cell Disease, Stem Cell Research, Stem Cell Research - Nonembryonic - Human, Genetics, Aetiology, 2.1 Biological and endogenous factors, Adenine, Anemia, Sickle Cell, CRISPR-Cas Systems, Cell Line, Clustered Regularly Interspaced Short Palindromic Repeats, Cytosine, Fetal Hemoglobin, Gene Editing, Hematopoietic Stem Cells, Humans, Point Mutation, Promoter Regions, Genetic, beta-Globins, beta-Thalassemia, gamma-Globins, base editing, globin regulation, HPFH mutations, beta-hemoglobinopathies, fetal hemoglobin, CRISPR, Cas9, Base editing, Beta hemoglobinopathies, Fetal hemoglobin, Globin regulation, HBGpromoter, Sickle cell disease, Beta-thalassemia, Large deletions, CD34+HSPCs, CRISPR/Cas9, beta hemoglobinopathies, beta-thalassemia, cd34+ hspcs, chromosomes, crispr/cas9, gene expression, genetics, genomics, hbgpromoter, hpfh mutations, large deletions, sickle cell disease, Biochemistry and Cell Biology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Naturally occurring point mutations in the HBG promoter switch hemoglobin synthesis from defective adult beta-globin to fetal gamma-globin in sickle cell patients with hereditary persistence of fetal hemoglobin (HPFH) and ameliorate the clinical severity. Inspired by this natural phenomenon, we tiled the highly homologous HBG proximal promoters using adenine and cytosine base editors that avoid the generation of large deletions and identified novel regulatory regions including a cluster at the -123 region. Base editing at -123 and -124 bp of HBG promoter induced fetal hemoglobin (HbF) to a higher level than disruption of well-known BCL11A binding site in erythroblasts derived from human CD34+ hematopoietic stem and progenitor cells (HSPC). We further demonstrated in vitro that the introduction of -123T > C and -124T > C HPFH-like mutations drives gamma-globin expression by creating a de novo binding site for KLF1. Overall, our findings shed light on so far unknown regulatory elements within the HBG promoter and identified additional targets for therapeutic upregulation of fetal hemoglobin.

Published
2022

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