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CHOLELITHIASIS, A WIDESPREAD GLOBAL CONCERN, OFTEN NECESSITATES SURGERY. SYMPTOMS VARY, AND GALLSTONES MAY NOT SOLELY TRIGGER SYMPTOMS, REQUIRING PRECISE DIAGNOSIS TO PREVENT UNNECESSARY CHOLECYSTECTOMIES. EMPLOYING UPPER GI ENDOSCOPY ASSISTS IN ACCURATE DIAGNOSIS, AVERTING SYMPTOM MISINTERPRETATION. THIS STUDY DELVES INTO THE CORRELATION BETWEEN CHOLELITHIASIS, GERD, AND THEIR SYMPTOMS, ADVOCATING PREOPERATIVE UPPER GI ENDOSCOPY TO DETECT ASSOCIATED UPPER GI DISORDERS AND MINIMIZE UNNECESSARY SURGERIES. THE AIM IS TO PROBE THE RELATIONSHIP BETWEEN GERD AND CHOLELITHIASIS. OBJECTIVES INCLUDE EVALUATING GERD SYMPTOMS USING THE "GERDQ" SCORE, SCRUTINIZING UPPER GI ENDOSCOPY FINDINGS, AND CORRELATING GERDQ SCORES WITH ENDOSCOPY RESULTS IN 120 PATIENTS FROM GMC, GGH ANANTAPURAMU. INCLUSION CRITERIA ENCOMPASS PATIENTS AGED 18 OR OLDER WITH CONFIRMED GALLBLADDER STONES VIA ABDOMINAL ULTRASOUND, CONSENTING TO PARTICIPATE IN THE STUDY. EXCLUSIONS COMPRISE COMPLEX GALLSTONE CONDITIONS. STATISTICAL ANALYSIS PERFORMED USING SPSS 16.0 SOFTWARE. AMONG 120 PATIENTS WITH DYSPEPTIC SYMPTOMS AND CONFIRMED CHOLELITHIASIS, THOSE AGED 30-60 YEARS (65.8%) WERE PREDOMINANT, WITH FEMALES CONSTITUTING 64.2%. NAUSEA, REGURGITATION, HEARTBURN, AND ABDOMINAL PAIN WERE PREVALENT SYMPTOMS, WITH GASTRITIS/GASTRIC ULCERS (45.8%) AS THE MOST FREQUENT ENDOSCOPIC FINDINGS. THE GERDQ SCORE EFFICIENTLY SCREENS PATIENTS AND HAS POSITIVE CORRELATION WITH GERD. TYPICAL ENDOSCOPIC FINDINGS INCLUDE GASTRITIS/GASTRIC ULCERS, HIATUS HERNIA, ESOPHAGITIS, AND DUODENITIS. INITIAL MEDICAL MANAGEMENT IS ADVISED FOR PATIENTS WITH DYSPEPSIA, GALLSTONES, HIGH GERDQ SCORES, AND SIGNIFICANT ENDOSCOPIC FINDINGS. ROUTINE PREOPERATIVE UPPER GI ENDOSCOPY IS RECOMMENDED FOR ALL DYSPEPTIC PATIENTS WITH GALLSTONE DISEASE TO AVOID UNNECESSARY CHOLECYSTECTOMY. [ABSTRACT FROM AUTHOR]