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2. Beyin Manyetik Rezonans Görüntüsünde Anatomik Atlas Oluşturma Yöntemi ve Anatomi Eğitimine Katkısı.

Author

Soysal, Handan, Acer, Niyazi, and Örs, Orhan Polat

Abstract

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Published
2024
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4. Anatomical characterization of ADHD using an atlas-based analysis: A diffusion tensor imaging study

Author

Acer Niyazi, Dolu Nazan, Zararsiz Gokmen, Dogan Mehmet Sait, Gumus Kazim, Ozmen Sevgi, Kara Ali Yucel, Soysal Handan, Per Huseyin, and Bilgen Mehmet

Subjects
Biotechnology, TP248.13-248.65
Abstract

Purpose: To examine brain diffusion characteristics in pediatric patients with attention deficit hyperactivity disorder (ADHD) using diffusion tensor imaging (DTI) and an atlas-based anatomical analysis of the whole brain and to investigate whether these images have unique characteristics that can support functional diagnoses. Materials and Methods: Seventeen children with ADHD and ten control subjects (all age-matched) underwent MRI scans. The Institutional Ethics Board approved this study. Morphometric analysis was performed using MriStudio software. The diffusion images were normalized using a linear transformation, followed by large deformation diffeomorphic metric mapping (LDDMM). For 189 parcellated brain regions, the volume, fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were measured. Results: Children with ADHD were found to have increase in the body of lateral ventricle volumes compared to the control. Increased MD was found in the deep gray matter, amygdala, thalamus, substantia nigra, and also the cerebellum left and right side. Increased RD was found in the deep gray matter, caudate, thalamus, substantia nigra and hippocampus left and right side compared to the control. Significant elevated FA was found in the bilateral splenium of the corpus callosum in ADHD patients. Conclusion: Children with ADHD display abnormal diffusion characteristics and anatomical features compared to healthy controls. DTI can provide sensitive information on integrity of white matter (WM) and intra-WM structures in ADHD.

Published
2017
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8. Poster presentations

Author

Aksu, Funda, Topacoglu, Hakan, Arman, Candan, Atac, Aytul, Tetik, Suleyman, Hasanovic, Aida, Kulenovic, Amela, Mornjakovic, Zakira, Pikula, Branko, Sarac-Hadzihalilovic, Aida, Voljevica, Alma, Bamac, Belgin, Colak, Tuncay, Alemdar, Murat, Dundar, Gulmine, Selekler, Macit, Dincer, Ozgur, Colak, Enis, Ozbek, Aydin, Kilic, Cenk, Kamburoglu, Kivanc, Ozen, Tuncer, Kavak, Vatan, Kirici, Yalcin, Oztas, Emin, Soysal, Handan Altinkaya, Unur, Erdogan, Ekinci, Nihat, Karaca, Omur, Malakhova, Olga, Kocaoglu, Murat, Toker, Serdar, Taser, Figen, Kilincoglu, Volkan, Yurtgun, Mustafa Fahri, Dalcik, Cannur, Zeybek, Ali, Baroncini, Marc, Peltier, Johann, Jissendi, Patrice, Pruvo, Jean-Pierre, Francke, Jean-Paul, Prevot, Vincent, Kosif, Rengin, Arifoglu, Yasin, Diramali, Murat, Sarsilmaz, Mustafa, Kose, Evren, Ogeturk, Murat, Akpinar, Burhan, Kus, Ilter, Meydan, Sedat, Kara, Alev, Kurtoglu, Zeliha, Tekdemir, Ibrahim, Elhan, Alaittin, Bas, Orhan, Odaci, Ersan, Mollaoglu, Hakan, Ucok, Kagan, Kaplan, Suleyman, Senoglu, Mehmet, Nacitarhan, Vedat, Kurutas, Ergul Belge, Senoglu, Nimet, Altun, Idris, Atli, Yalcin, Ozbag, Davut, Karakas, Sacide, Bilgin, M. Dincer, Tellioglu, Ayfer Metin, Ozlem, Sercin, Akcanal, Betul, Yildiz, Yuksel, Gunes, Hakki, Kose, Hayrullah, Uzum, Ibrahim, Gundogmus, Umit Naci, Caglayan, Cigdem, Pavlova, Velichka, Dimitrova, Mashenka, Georgieva, Lilia, Nikolova, Elena, Uzmansel, Deniz, Ozturk, Nail Can, Saylam, Canan Yurttas, Ozgiray, Erkin, Orhan, Mustafa, Cagli, Sedat, Zileli, Mehmet, Ozkan, Derya, Akkaya, Taylan, Comert, Ayhan, Balikci, Nilgun, Ozdemir, Esra, Gumus, Haluk, Ergul, Zafer, Kaya, Oskay, Altun, Serdar, Unlu, R. Erkin, Orbay, Hakan, Kim, Deog-Im, Han, Seung-Ho, Kim, Yi-Suk, Kim, Ho-Jeong, Lee, Kyu-Seok, Elcioglu, Omur, Ozden, Hilmi, Guven, Gul, Imre, Nurcan, Yalcin, Bulent, Ozan, Hasan, Akyer, Pinar, Guvencer, Mustafa, Karatosun, Vasfi, Sagoo, Mandeep Gill, Aland, Rachel Claire, Ustuner, Derya, Ustuner, M. Cengiz, Ai, Jafar, Ghazi, Seyed Reza, Mansouri, Seyed Hadi, Tuncer, Mehmet Cudi, Aluclu, Mehmet Ufuk, Karabulut, Ozlen, Hatipoglu, Eyup Savas, Nazaroglu, Hasan, Icke, Cigdem, Akbay, Emrah, Gunay, Turkan, Icke, Suleyman, Yildiz, Selda, Yazar, Fatih, Barlas, Barcin Orhan, Zahoi, Delia Elena, Kavakli, Ahmet, Tas, Ufuk, Dabak, Durrin Ozlem, Sapmaz, Hilal Irmak, Kocabiyik, Necdet, Ozer, Cenk Murat, Ozcan, Ayhan, Elevli, Levent, Desdicioglu, Kadir, Alanbay, Ibrahim, Govsa, Figen, Saylam, Canan Y., Akdogan, Ilgaz, Kiroglu, Yilmaz, Onur, Sule, Evcil, Emine Hilal, Cankara, Neslihan, Malas, Mehmet Ali, Kalcioglu, M. Tayyar, Duman, Serdar, Ulcay, Tufan, Uzun, Ahmet, Karabulut, Zulfu, Barut, Cagatay, Sevinc, Ozdemir, Yurdakan, Gamze, Kacar, Dundar, Erdogan, Ali Riza, Kurt, Hulyam, Demir, Bunyamin, Saltan, Mustafa, Burukoglu, Dilek, Ustuner, Mehmet Cengiz, Degirmenci, Irfan, Erdogan, Aliriza, Damar, Ozlem, Is, Merih, Bayramoglu, Gokhan, Kabay, Sahin, Uysal, Onur, Senturk, Hakan, Bayramoglu, Aysegul, Ozbayar, Cansu, Kutlu, Ali, Canbek, Mediha, Cevli, Salih Cenap, Hancerlioglu, Oguz, Koplay, Mustafa, Aksakalli, Elif, Dikici, Fatih, Kale, Aysin, Gayretli, Ozcan, Gurses, Ilke Ali, Ozdemir, Senem Turan, Ercan, Ilker, Baskan, Emel Bulbul, Yilmaz, Mediha, Ozkaya, Guven, Saricaoglu, Hayriye, Erturk, Mete, Kayalioglu, Gulgun, Uzel, Mehmet, Kahraman, Guler, Tanyeli, Ercan, Soyluoglu, Ali Ihsan, Tacar, Orhan, Demirant, Ayda, Bilgin, Murat, Karadede, Aziz, Aktas, Ayfer, Evcil, E. Hilal, Koyuncu, Esra, Sulak, Osman, Albay, Soner, Ozguner, Gulnur, Ozbek, Ahmet, Ozbek, Elvan, Ozturk, A. Hakan, Demirci, Tuba, Ciftcioglu, Engin, Demir, Mehmet Tevfik, Kopuz, Cem, Eroglu, Esra, Gedikli, Semin, Ozyurek, Hamit, Nural, Mehmet Selim, Incesu, Lutfi, Ogur, Gonul, Kara, Engin, Celebi, Baris, Yildiz, Altan, Altunkaynak, B. Zuhal, Kuvat, Samet Vasfi, Tagil, Suleyman Murat, Ertekin, Cumhur, Uysal, Hilmi, Bademkiran, Fikret, Albayrak, Nural, Esmer, Ali Firat, Coskun, Nigar Keles, Sindel, Muzaffer, Kizilay, Ferah, Yalin, Sevket, Karapinar, Nevin, Tokdemir, Mehmet, Karakurt, Lokman, Tumkaya, Levent, Korkmaz, Adnan, Ayas, Bulent, Ciftci, Nusret, Terzi, Yuksel, Baran, Ozlem, Nergiz, Yusuf, Akkus, Murat, Aluclu, Ufuk, Topal, Askin Ender, Yuksel, Dilek, Acar, Halil Ibrahim, Kendir, Simel, Hekimoglu, Emre, Basman, Deniz, Duman, Sunay, Ozener, Baris, Pelin, Can, Zagyapan, Ragiba, Kurkcuoglu, Ayla, Koc, Mustafa, Erdinc, Meral, Erdinc, Levent, Kelle, Ilker, Sancakdar, Enver, Cetin, Nil, Tunik, Selcuk, Yildirim, Ayse, Kaplanoglu, Iskender, Ayaz, Ercan, Ilhan, Necip, Okumus, Mehmet, Yuksel, Kasim Zafer, Ciralik, Harun, Yilmaz, Zeki, Gumusalan, Yakup, Gamsizkan, Mehmet, Kazkayasi, Mustafa, Dogan, Nadire Unver, Uysal, Ismihan Ilknur, Karalezli, Aylin, Fazliogullari, Zeliha, Buyukmumcu, Mustafa, Bozkurt, Mehmet Cem, Cicekcibasi, Aynur Emine, Demiryurek, Deniz, Ozsoy, M. Hakan, Bayramoglu, Alp, Tuccar, Eray, Baran, Ozlem Pamukcu, Soker, Sevda, Bahceci, Selen, Nasir, Yasemin, Yilmaz, Mehmet Tugrul, Cicekcibasi, Emine Aynur, Ulusoy, Mahinur, Gunaslan, Pervin, Bilge, Nuray, Akkaya, Muzaffer, Genc, Abdurrahman, Akcer, Sezer, Gonul, Yucel, Cosar, Emine, Koken, Gulengul, Ari, Ilknur, Bakirci, Sinan, Kafa, Ilker Mustafa, Uysal, Murat, Karabulut, Ahmet Kagan, Keles, Bahar, Emlik, Dilek, Uyar, Yavuz, Ozturk, Kayhan, Yilmaz, Neslihan Altuntas, Salbacak, Ahmet, Kacira, Burkay Kutluhan, Arazi, Mehmet, Demirci, Serafettin, Kiresi, Demet, Gumus, Serter, Seker, Muzaffer, Uyar, Mehmet, Astaneh, Mohammad Ebrahim, Khorshid, Alireza, Uygur, Ramazan, Songur, Ahmet, Sonmez, Osman Fikret, Dogan, Kamil Hakan, Kolcu, Giray, Iliescu, Madalina, Bordei, Petru, Iliescu, Dan, Ciobotaru, Camelia, Lucescu, Viorel, Covaleov, Anatoli, Ionescu, Constantin, Guirao, Miguel, Páramo, E., Mutuberria, R., Sánchez-Montesinos, I., Roda, O., Girón, F., Lopez-Soler, Miguel, Roda, Olga, Campos-López, Raúl, Guirao-Piñeiro, Miguel, Pascual-Morenilla, Maria Teresa, Sanchez-Montesinos, Indalecio, Pascual, Maria Teresa, Garzon, I., Serrato, D., Nieto-Aguilar, R., Sanchez-Montesinos, I., Sanchez-Quevedo, M., Ozdemir, M. Bulent, Ozean, R. Hakan, Bagdatli, Dilek, Adiguzel, Esat, Dogan, Zumrut, Aycan, Ozlem, Vardi, Nigar, Erkal, Haldun Sukru, Ozturk, Hakan, Mocanu, S., Stefanescu, C., Ionescu, A., Talpes, Raluca, Sapte, Elena, Dina, Constantin, Surdu, Loredana, Bulbuc, Ionut, Medina, M. T., Medina, J., López-Soler, M., Martin-Oviedo, Carlos, Lowy-Benoliel, Alejandro, Maranillo, Eva, Martinez-Guirado, Tomas, Sañudo, Jose, Scola, Bartolome, Vazquez, Teresa, Arráez-Aybar, L. A., Conejo-Menor, J. L., Gonzáles-Gómez, C. C., Torres-García, A. J., Nasu, Hisayo, Chiba, Shoji, Gutierrez-Semillera, M., Paksoy, Yahya, Kalaycioglu, Ahmet, Yildirim, Mehmet, Ozyasar, Ali, Ozdogmus, Omer, Cakmak, Yusuf Ozgur, Verimli, Ural, Cavdar, Safiye, Yildizhan, Begum, Aktan Ikiz, Z. Asli, Ucerler, Hulya, Ozgur, Zuhal, Yilmaz, Seher, Demirtas, Abdullah, Mavili, Ertugrul, Hacialiogullari, Mehtap, Susar, Hatice, Arslan, Seda, Aycan, Kenan, Ozkaya, Vecihi, Pilmane, Mara, Boka, Sarmite, Ortug, Gursel, Ramirez, Carlos, Pascual-Font, Aran, Valderrama-Canales, Francisco, Kucukalic, Abdulah, Kapur, Eldan, Talovic, Elvira, Baca, Vaclav, Grill, Robert, Horak, Zdenek, Kachlik, David, Dzupa, Valer, Konarik, Marek, Knize, Jakub, Veleminsky, Petr, Smrzova, Tereza, Otcenasek, Michal, Chmelova, Jana, Kheck, Michal, Kheck, Sr., Michal, Cupka, Tomas, Hnatek, Lukas, van der Meijs, Floris, Cech, Pavel, Musil, Vladimir, Ozkan, H. Mustafa, Muratli, S. Kivanc, Tayefi, Hamid, Ergur, Ipek, Kiray, Amac, Toktas, Muhsin, Alkoc, Ozan, Acar, Tolgahan, Uzun, Ibrahim, Ozen, Oguz Asian, Aycicek, Abdullah, Alkoc, Ozan Alper, Unlu, Mehmet, Corumlu, Ufuk, Ikiz, Ihsaniye Coskun, Oygucu, I. Hakan, Sendemir, Erdogan, Kaner, Tuncay, Caglar, Veli, Eser, Olcay, Demir, Mehmet T., Iyigun, Omer, Pirzirenli, Gokhan, Kaya, Ahmet Hilmi, Aydin, Mennan Ece, Celik, Fahrettin, True, Hakan, Ozkaya, Sevket, Ergur, Bekir Ugur, Zeybek, Gulsah, Bacakoglu, Kadir, Tadjalli, Mina, Poostpasand, Aghdas, Mansouiri, Seid Hadi, Allahvaisi, Ozra, Soleimanirad, Jafar, Nikkhoo, Bahram, Nagato, Yasukazu, Haruki, Yasuo, Yazawa, Komazo, Okazaki, Tutomu, Haida, Munetaka, Imai, Yutaka, Peirouvi, Thmineh, Mahzad-Sadaghiani, Mehrzad, Noroozinia, Farahnaz, Siamak, Salami, Farjah, Gholamhosseine, Mola, Sima, Biegaj, Ewa, Skadorwa, Tymon, Pawlewicz, Konrad, Kapolka, Robert, Chachulska, Agata, Zabicka, Joanna, Krasowska, Aleksandra, Prusik, Alicja, Jaczewski, Grzegorz, Kolesnik, Adam, Taghavi, M. Mohsen, Alavi, S. Hasan, Moallem, S. Adel, Safikhani, Zahed, Panahi, Marzieh, Dabiri, Shahriar, Shekaari, Majid Asadi, Latorre, Rafael, Soria, Federico, Lopez-Albors, Octavio, Sarria, Ricardo, Ayala, Inacio, Serrano, Inma, Perez-Cuadrado, Enrique, Musienko, Vladimir, Tkachenko, Dmitry, Colakoglu, Neriman, Kus, Murat Abdulgani, Jalali, Mahdi, Nikravesh, Mohammad Reza, Moeen, Abbas Ali, Karimfar, Mohammad Hassan, Rafighdoost, Houshang, Mohammadi, Shabnam, Korneeva, Marina, Rafighdoust, Houshang, Lovasova, Kvetuse, Bolekova, Adriana, Kluchova, Darina, Sulla, Igor, Kapitonova, Marina Yurievna, Syed Ahmad Fuad, Syed Baharom, Jayakaran, Flossie, Shams, Ali Reza, Aghaee, Fereshteh, Baqer, Zohreh, Faroki, Mohamad, Das, Srijit, Kassim, Normadiah, Latiff, Azian, Suhaimi, Frihah, Ghafar, Norzana, Hlaing, Khin Pa Pa, Maatoq, Israa, Othman, Faizah, Kiray, Muge, Bagriyanik, Husnu Alper, Pekcetin, Cetin, Ozogul, Candan, Fidan, Mustafa, Suhaimi, Farihah, Sun, Fei, Sanchez-Margallo, Francisco, Gil, Francisco, Crisostomo, Verónica, Uson, Jesus, Ramirez, Gegorio, Turamanlar, Ozan, Kirpiko, Oguz, Haktanir, Alpay, Climent, Salvador, Losilla, Sergio, Climent, Maria, Sarikcioglu, Levent, Senol, Yesim, Yildirim, Fatos B., Utuk, Arzu, Kunicki, Jacek, Pasbakhsh, Parichehr, Omidi, Negar, Omidi, Hamed, Nazhvani, Fatemeh Dehghani, Ghalebi, Seyed Razi, Javan, Nima, Mohagery, Akrami, Bideskan, Ali Reza Ebrahimzadeh, Taheri, Mohammad Mehdi Hassanzadeh, Fazel, Ali Reza, Tiengo, Cesare, Macchi, Veronica, Stecco, Carla, Porzionato, Andrea, Mazzoleni, Franco, De Caro, Raffaele, Clemente, Alberto, Morra, Aldo, Greco, Pietro, Pavan, Piero, Natali, Arturo, Demir, Mehmet, Dokur, Mehmet, Acer, Niyazi, Mavi, Ayfer, Matveeva, Niki, Lazarova, Dobrila, Korneti, Kostandina, Jovevska, Svetlana, Jurkovik, Dragica, Papazova, Meri, Havasi, Masoumeh, Alboghobeish, Naeim, Savari, Ahmad, Salamat, Negin, Sharifi, Mozafar, Kwak, Hyun-Ho, Hu, Kyung-Seok, Kim, Gyoo-Cheon, Park, Bong-Soo, Kim, Hee-Jin, Sinav, Ahmet, Gulati, Adarsh K., Gulati, Nidhi K., Alshammary, Hussien, Nazhvani, Seifollah Dehghani, Vafafar, Amir, Esmaeilpour, Tahereh, Bahmanpour, Soghra, Elyasi, Leila, Monabbati, Ahmad, Ghanadi, M., Paryani, Mohammad Reza, Gilanpour, Hassan, Amirsam, Banino, Omaña, Rodrigo Elizondo, López, Santos Guzmán, De la Garza Castro, Oscar, Vega, Edgar Urrutia, Lopez, Santos Guzman, Talebpour, Freshteh, Golmohammadi, Rahim, Dashti, Golamreza, Atlasi, Mohammad Ali, Mehdizadeh, Mehdi, Bahadori, Mohammad Hadi, Joghataei, Mohammad Taghi, Hatami, Leili, Boroujeni, Mandana Beigi, Estakhr, Jasem, Esfandiary, Ebrahim, Marzban, Mohsen, Bakhtiary, Mehrdad, Modiry, Navid, Jafarpur, Mokhtar, Mofidpur, Hassan, Alavi, S. Hassan, Mahmoudian, Alareza, Taghavi, Mohmmad Mohsen, Jafarpour, Mokhtar, Mahmoudian, Ali Reza, Sanjarmousavi, Nasrin, Doassans, Ines, Sorrenti, Natalia, Decuadro, German, Saibene, Andres, Poumayrac, Marie, Laza, Sebastian, Almiron, Carina, Vergara, Maria Elena, Soria, Victor, Lasa, Sebastian, Perez, Adolfo, Castro, Gabriela, Maria, Ana Santa, Soleimani, Mansoureh, Katebi, Majid, Bakhshayesh, Masoomeh, Oner, Mithat, Halici, Mehmet, Yikilmaz, Ali, Guney, Ahmet, Turk, Yildirim, Edizer, Mete, Beden, Umit, Icten, Nihal, Afshar, Mohammad, Hasanzadeh Taheri, Mohammad Mehdi, Moalem, Adel, Golalipour, Mohammad Jafar, Tamizi, Azadeh, Ahi, Mohammad, Mohammadpour, Shahram, Maiery, Ardeshir, Acikel, Cengiz, Ulkur, Ersin, Karagoz, Huseyin, Celikoz, Bahattin, Bedi, Kuldip, Ginus, Partadiredja, Golalipoor, Mohammad Jafar, Mohammadi, Mohammad Reza, Jhand, Poya, Mansourian, Azad Reza, Hosseinpoor, Kanizreza, Keshtkar, Abbas Ali, Alsaffar, Raith, Balajadeh, Babak Kabiri, Ghafari, Soraya, Azarhosh, Ramin, Fazeli, Seyyed Amirhossein, Jahanshahi, Mehrdad, Gharravi, Annen Mohammad, Alicioglu, Banu, Karakas, Hakki Muammer, Harma, Ahmet, Yang, Hun-Mu, Won, Sung-Yoon, Lee, Jae-Gi, Lee, Ju-Young, Lee, Jeong-Yong, Kim, Yoo-Ri, Song, Wu-Chul, Koh, Ki-Seok, Hwang, Eu-Na, Choi, Hyun-Gon, Kim, Soon-Heum, Kim, Soo-Young, Hur, Mi-Sun, Ulucam, Enis, Celbis, Osman, Kim, Da-Hye, Hong, Hee-Suk, Kim, Hyun-Joo, Choi, Jong-Hoon, Park, Jong-Tae, Kim, Hyeon-Cheol, Abbasi, Hamed, Hosseinipanah, Seyed Mohammad, Hosseini, Mohammad, Amani, A., Ashrafi, H. R., Sadeghimehr, Mohsen, Kim, Hyun-Ju, Sheverdin, Vadim, Amani, Zahra, Ashrafi, Alireza, Ashrafi, Ali Reza, Javad, Hami, Kachap, Mokhtar Jafarpoor, Laza, Sebastián, Poumayrac, Marie Catherine, Doassans, Inés, Vergara, María Elena, Almirón, Carina, Soria, Víctor, Rivara, Alvaro, Sirilo, Angela, Freire, Diego, Cirillo, Angela, Veragara, Maria Elena, Krmek, Vlado, Krmek, Nikola, Jo-Osvatic, Ana, Nikolic, Vasilije, Radic, Radivoje, Tubbs, R. Shane, Loukas, Marios, Fogg, Quentin, Ashwood, Neil, Cilingiroglu, Serpil, Ozbakir, Cemal, Mazoochi, Tahereh, Sabanciogullari, Vedat, Gumus, Cesur, Erdil, F. Hayat, Cimen, Mehmet, Moodi, Hesam, Ghiasi, Fateme, Akbari, Asghar, Hami, Javad, Khazei, Majid, Haghparast, Elham, Mitsakis, Ioannis, Anastasiou, Aikaterini, Mitsakis, Menelaos, Sianou, Kyriaki, Hainoglou, Roxani, Francisco, Margarida, Mitsaki, Charikleia, Konstantinidi, Maria, Prapa, Stamatia, Leksan, Igor, Mrcela, Tomislav, Selthofer, Robert, Kermanian, Fatemeh, Mahmoudian, Alireza, Ahmadpoor, Mahmood Erfanian, Dalili, Naser, Elian, Amir Hossein, Moaiery, Ardesheer, Jamalpour, Zahra, Nourani, Mohammad Reza, Asgari, Alireza, Hassanzadeh Taheri, Mohammad Mehdi, Ebrahimzadeh, Alireza, Eftekharvaghefi, Seyed Hasan, Mohammadi, Abbas, Sheibani, Vahid, Nematollahi-Mahani, Seyed Noureddin, Latifpour, Mastafa, Deilami, Masood, Soroure-Azimzadeh, Behzad, Nabipour, Fatemeh, Najafipour, Hamid, Nakhaee, Nouzar, Yaghoobi, Mohammad, Eftekharvaghefi, Rana, Salehinejad, Parvin, Azizi, Hasan, Riasi, Hamid Reza, Nobakht, Maliheh, Asalgoo, Sara, Rahbar, Roshanak, Najafzadeh, Norooz, Moosavizadeh, Kazem, Ezzatabadypour, Massood, Majidi, Masoud, Malekpor-Afshar, Reza, Karimzade, Fariba, Hoseini, Mahmood, Bayat, Mohamad, Gorgi, Ali, Nezhadi, Akram, Bakhtiari, Mehrdad, Jazi, Homa Rasooli, Jafaryan, Maryam, Haghir, Hosein, Hosseini, Mahmood, Rahimi, Sadegh, Rassouli, Fatemeh Behnam, Gorji, Ali, Habibi, Aliasghar, Pouya, Fatemeh, Dabiri, Shahryar, Mousavi, A., Rajabalian, Saeed, Abolidokht, A., Khanlarkhani, Neda, Naderian, Homayoun, Berjis, Nezamedin, Namavar, Mohamad Reza, Talaei, Tahereh, Mazaheri, Zohreh, Monabati, Ahmad, Kosar, Mehmet Ilkay, Karacan, Kezban, Chegini, Hamidreza, Nikzad, Hossein, Ayhan, Egemen, Ustundag, Sinan, Akkin, Salih Murat, Ogut, Tahir, Rayegan, Parviz, Meibodi, Mohamad Ali Emami, Ghaem, Reza Montazer, Zargarpoor, Rosa, Eftekhar Vaghefi, Seyd Hasan, Moshkdanian, Ghazale, Poya, Fateme, Kohestani, Hamid, Abarghoeai, Roozbeh Rayegan, Abarghoeai, Parviz Rayegan, Eftekhar Vaghefi, Seyed Hasan, Mahmodi, Abolghasem Amir, Poraboli, Ali, Kohestani, Hamid Reza, Vaghefi, Raena Eftekhar, Eftekhar Vaghefy, Seyed Hasan, Vaghefy, Raena Eftekhar, Abarghoeai, Parviz Raygan, Saba, Mohamad, Gharravi, Anneh Mohammad, Javadnia, Fatemeh, Zhaleh, Mohsen, Nezhad, Dariush Bijan, Gholami, Mohammad Reza, Piagkou, Maria, Aikaterini, Vassiliki Kouki, Piagkos, Giannoulis, Douvetzemis, Stergios, Skandalakis, Panagiotis, Anagnostopoulou, Sophia, Papadopoulos, Nikolaos, Celik, H. Hamdi, Tatar, Ilkan, Tatar, Emel Cadalli, Mocan, Burce Ozgen, Sargon, Mustafa F., Denk, C. Cem, Rasoolijazi, Homa, Joghataie, Mohammad Taghi, Roghani, Mehrdad, Akkin, Salin Murat, Dinc, Gulten, Kurklu, Mustafa, Ozboluk, Sener, Komurcu, Mahmut, Koebke, Jürgen, Balioglu, Mehmet Bulent, Kaygusuz, Mehmet Akif, Bozkus, Ferdi Sefa, Korkmaz, Ozgur, Bayram, Sule Biyik, Can, Mehmet Ali, Nasiri, Ebrahim, Jafar-Kazemi, Koroush, Hosseini, Melina, Maghoul, Shahin, Soleimani, Mansooreh, Amini, Abdollah, Hassanzade, Mohamad Mahdi, Davari, Mohammad Hossein, Van Hoof, Tom, Gomes, Germano T., Audenaert, Emmanuel, Verstraete, Koenraad, Kerckaert, Ingrid, D’Herde, Katharina, Benninger, Brion, Hedley, Gil, Filipoiu, Florin Mihail, Tarta, Eugen, Enyedi, Mihali, Pantu, Cosmin, Stanciulescu, Razvan, Skobowiat, Cezary, Calka, Jaroslaw, Majewski, Mariusz, Rezaian, Maryam, Yaghoobfar, Akbar, Hamedi, Somayeh, and Shomali, T.

Published
2009
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10. A Volumetric Study of the Corpus Callosum in the Turkish Population.

Author

Soysal, Handan, Acer, Niyazi, Özdemir, Meltem, and Eraslan, Önder

Subjects
*CORPUS callosum, *TURKS, *MAGNETIC resonance imaging, *AGE groups, *NEURAL development, *MAGNETIC resonance
Abstract

Objective  The aim of this study is to measure the average corpus callosum (CC) volume of healthy Turkish humans and to analyze the effects of gender and age on volumes, including the genu, truncus, and splenium parts of the CC. Patients and Methods  Magnetic resonance imaging brain scans were obtained from 301 healthy male and female subjects, aged 11 to 84 years. The median age was 42 years (min–max: 11–82) in females and 49 years (min–max: 12–84) in males. Corpus callosum and its parts were calculated by using MRICloud. CC volumes of each subject were compared with those of the age and gender groups. Results  All volumes of the CC were significantly higher in males than females. All left volumes except BCC were significantly higher than the right volumes in both males and females. The oldest two age groups (50–69 and 70–84 years) were found to have higher bilateral CC volumes, and bilateral BCC volumes were also higher than in the other two age groups (11–29 and 30–49 years). Conclusion  The results suggest that compared with females/males, females have a faster decline in the volume of all volumes of the CC. We think that quantitative structural magnetic resonance data of the brain is vital in understanding human brain function and development. [ABSTRACT FROM AUTHOR]

Published
2022
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14. Sıçan fetuslarında fenitoin, folik asit ve vitamin E'nin kemik gelişimi üzerine etkileri

Author

Soysal, Handan, Soysal, Handan, and Anatomi Ana Bilim Dalı

Subjects
Fetus, Folic acid, Bone and bones, Phenytoin, Vitamin E, Anatomi, Anatomy, Rats
Abstract

Bu çalışmada, Fenitoin'in (PHT) sıçan embriyonal gelişim sürecinde oluşturduğu iskelet sistemi malformasyonlarını önlemede Folik asit (FA) ile Vitamin E (Vit E)'nin koruyucu rolünün belirlenmesi hedeflenmiştir.Bu amaçla 25 adet erişkin dişi Wistar-albino türü sıçan kullanıldı. 3 dişi ve 1 erkek sıçan aynı kafese konuldu. Gebe olan sıçanlar tespit edildi. Sıçanlar birinci grup kontrol, ikinci grup PHT, üçüncü grup PHT+FA ve dördüncü grup PHT+Vit E olarak dört gruba ayrıldı. Gebe sıçanlara gebeliklerinin 8., 9. ve 10. günlerinde kontrol grubuna 0.3 ml serum fizyolojik (intraperitoenal), ikinci gruba 25 mg/kg dozunda fenitoin (intraperitoneal) verildi. Üçüncü gruptaki dişi sıçanların içme suyuna gebeliğin ilk gününden itibaren her gün 400 µg/kg folik asit katıldı. Ayrıca bu gruptaki gebe sıçanlara gebeliğin 8., 9., ve 10. günlerinde, 25 mg/kg dozunda fenitoin (intraperitoenal) enjekte edildi. Dördüncü gruptaki gebe sıçanlara gebeliğin 8., 9., ve 10. günlerinde 25 mg/kg dozunda fenitoin (intraperitoenal) verildi. Ayrıca bu gruptaki gebe sıçanlara PHT enjeksiyonundan 1 saat önce Vitamin E (?-Tocopherol) zeytinyağında çözeltilerek 250 mg/kg dozunda gastrik intübasyonla verildi. Tüm gruplarda gebeliklerinin 20. gününde sezeryanla fetuslar alındı. Elde edilen fetusların boyları ve ağırlıkları tespit edildi. İskelet sistemi gelişimi ikili iskelet boyama yöntemi ile incelendi.PHT uygulamasından sonra fetusların kafatası kemiklerinde belirgin bir kemikleşme geriliği, son iki kaburgada şekil bozuklukları (dalgalanma) ve özellikle son altı kaburgadan sonraki interkostal aralıklarda geniş açılanmalar, ön ayak kemik ve kıkırdak gelişiminde gerilikler izlenmiştir. Gebelik sırasında PHT+FA ve PHT+Vit E verilen gruptaki iskelet sistemi ve özellikle de kosta anomalileri PHT grubuyla kıyaslandığında nispeten azalma olduğu görüldü.Ağırlık yönünden gruplar arasında bir fark olduğu tespit edildi (P

Published
2010

16. Lamotrigin kullanan epileptik ratların yeni doğan yavrularının karaciğerlerinde oksidatif hasarın incelenmesi

Author

KAMIŞLI, Özden, SOYSAL, Handan, DOĞAN, Zümrüt, EKİNCİ, Nihat, and TÜRKÖZ, Yusuf

Subjects
Lamotrijin,epilepsi,gebelik,karaciğer,oksidatif stres, Health Care Sciences and Services, Lamotrigine,epilepsy,pregnancy,liver,oxidative stress, Sağlık Bilimleri ve Hizmetleri
Abstract

The present study was performed to evaluate the effects of lamotrigine, which is a widely used antiepileptic drug for epilepsy treatment, on oxidative stress parameters in the liver of neonates. Ten adult Wistar-albino rats and twenty newborn of these rats were used in this study. Adult rats weighing 170–250 g were divided into five groups: the pregnant control group, experimental epilepsy group, lamotigine group, lamotrigine + experimental epilepsy group and lamotrigine + epilepsy + folic acid group. An experimental penicillin acute epilepsy model was created in pregnant rats on day 13 of pregnancy. The lamotrigine group was administered lamotrigine at 25 mg/day by intraperitoneal injection starting from the first day of pregnancy. The lamotrigine + folic acid group was administered 400 microgram/kg folic acid and 25 mg/day lamotrigine by intraperitoneal injection. We then waited for the rats to give birth. Immediately after birth, the glutathione, malondialdehyde, glutathione peroxidase and superoxide dismutase levels in the newborn rat liver were measured by spectrophotometry. The lamotrigine and lamotrigine + epilepsy groups showed significantly elevated liver malondialdehide levels, while glutathione peroxidase enzyme activation was significantly decreased compared to the control group. In the group administered folic acid together with lamotrigine, the liver tissue sample for malondialdehide levels showed a significant decrease, while glutathion and glutathion peroxidase levels increased. This study on pregnant rats demonstrated that lamotrigine use can lead to hepatic oxidative damage in newborn rats, and this oxidative tissue damage was prevented by folic acid use., Bu çalışmada amacımız epilepsi tedavisinde sıkça kullanılan antiepileptik ilaçlardan lamotirijinin yalnız veya folik asit ile birlikte gebelikte kullanımının yeni doğan yavruların karaciğerlerinde oksidatif stres parametreleri üzerine etkilerini araştırmaktır. Çalışmamız 170-250 gr ağırlığında 10 adet erişkin dişi Wistaralbino türü rat ve bunlardan doğan 20 yavru rat ile yapıldı. Ratlar; Gebe ratlar kontrol grubu, deneysel epilepsi grubu, lamotrijin grubu, lamotrijin+deneysel epilepsi grubu ve lamotrijin epilepsi+folik asit olarak beş gruba ayrıldı. Gebeliğin 13. Gününde gebe ratlara deneysel penisilin akut epilepsi modeli oluşturuldu. Lamotrijin grubuna gebeliğin ilk gününden itibaren her gün intraperitoneal enjeksiyon ile 25mg/gün dozunda lamotrijin verildi. Lamotrijin+folik asit grubuna her gün intraperitoneal enjeksiyon ile 25mg/gün dozunda lamotrijin ve 400µg/kg folik asit verildi. Daha sonra gebe ratların doğum yapmaları beklendi. Doğumdan hemen sonra yeni doğan ratların karaciğerlerinde glutatyon, malondialdehit, glutatyon peroksidaz ve superoksid dismutaz seviyeleri spektrofotometrik olarak ölçüldü. Lamotrijin ve lamotrijin+epilepsi gruplarına ait biyokimyasal değerler incelendiğinde, karaciğer malondialdehit anlamlı bir şekilde yükseldiği, glutatyon peroksidaz enzim aktivasyonlarının kontrol grubuna göre istatistiksel olarak anlamlı azalmış olduğu görüldü. Folik asit ile birlikte lamotrijin verilen grupta, karaciğer doku örneklerine ait malondialdehit düzeylerinin anlamlı azaldığı, glutatyon ve glutatyon peroksidaz düzeyinin arttığı tespit edildi. Gebe ratlar üzerinde gerçekleştirmiş olduğumuz bu çalışmada, lamotrijin kullanımının yeni doğan yavruların karaciğerlerinde erken dönemde bir oksidatif hasar meydana getirebileceği ancak meydana gelen oksidatif doku hasarının folik asit kullanıldığında engellendiği biyokimyasal olarak ortaya kondu

Published
2013

20. Prevalence of Chiari type I malformation on cervical magnetic resonance imaging: a retrospective study.

Author

Öktem, Hale, Dilli, Alper, Kürkçüoğlu, Ayla, Soysal, Handan, Yazıcı, Canan, and Pelin, Can

Subjects
ARNOLD-Chiari deformity, CERVIX uteri, MAGNETIC resonance imaging, SYRINGOMYELIA, HERNIA
Abstract

Objectives: Chiari malformation is characterized by caudal herniation of cerebellar tonsils from foramen magnum into the cervical canal on radiological images. Type I Chiari malformation is the herniation of cerebellar tonsils more than 3 mm which does not cause any symptoms until adulthood. In this study, we aimed to investigate the prevalence of Chiari type I malformation. Methods: In this retrospective study, cervical magnetic resonance images taken between 2013 and 2015 were retrospectively analyzed. The patients were 18-70 year old males and females. Type I Chiari malformation was defined as an inferior displacement of the cerebellar tonsils more than 3 mm below the opisthion-basion line. The patients with intracranial lesions, hydrocephalus or previous craniotomy were excluded from the study. Results: The prevalence of Chiari type I malformation was found as 4% when both genders were taken into consideration. The prevalence was 3.3% in females and 0.7% in males. Chiari type I malformation was associated with syringomyelia in 0.5% of females and 0.2% of males. In the present study, concomitant syringomyelia was observed in 0.7% of the patients. On the other hand, incidence of Chiari type I malformation was found relatively higher in the patients with scoliosis (15.4%). The ratio of this co-occurrence was higher in females (11.4%) when compared to the males (4%). Conclusion: In the present study, the prevalence of Chiari type I malformation was investigated in a large population, consisting of 2480 individuals, and its association with syringomyelia and scoliosis. [ABSTRACT FROM AUTHOR]

Published
2016
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22. THE EFFECTS OF DRIED APRICOT SUPPLEMENTATION ON DAILY FOOD INTAKE IN RATS.

Author

YILMAZ, İsmet, DOğAN, Zümrüt, and SOYSAL, Handan

Subjects
APRICOT, DIETARY supplements, FOOD consumption, SOLAR food drying, BODY weight, LABORATORY rats
Abstract

Copyright of Turkish Journal of Pharmaceutical Sciences is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2013

23. Effect of endostatin on 1,2-dimethylhydrazine-induced colon tumor in mice.

Author

Karaca, Omur, Ertekin, Tolga, Canoz, Ozlem, Ulger, Harun, Soysal, Handan, and Kus, Ilter

Subjects
COLON cancer treatment, METHYL hydrazine, DRUG synergism, NEOVASCULARIZATION, PEPTIDES, DRUG administration, HISTOPATHOLOGY, LABORATORY mice
Abstract

Endostatin, one of the most potent negative regulators of angiogenesis, is naturally occurring as an inhibitor of angiogenesis capable of inhibiting tumor growth and their metastases. We aimed to investigate the in vivo activities of low dose of recombinant human endostatin on 1,2-dimethylhydrazine (DMH)-induced mice colon cancer. Thirty male Balb-c mice were injected with DMH (20 mg/kg/week) subcutaneously once a week for 12 weeks to induce colon cancer. Twelve weeks after the last DMH injection, 7 µg rh-endostatin was injected every day for 6 weeks. The animals were killed after 30 weeks for histopathological examination. The weight of the animals, tumor inhibition rates, death rates and the distribution of the lesions in colon were evaluated after the mice were killed. The mean colonic lesions incidence in single tumor bearing mice was 11 ± 4.0 in those treated with DMH and 8.1 ± 3.7 in those treated with endostatin. When we look at the distribution of lesions in the colon, they occurred in the distal colon. At the end of our study, we noticed that the number of lesions decreased by 25% in the group of endostatin, considering the number of the lesions in the group of DMH. But there was no statistical difference between the mice treated with endostatin and those treated with DMH. It will be very significant to identify endostatin therapeutic effects as long as proper dose of endostatin is administrated at the proper time, duration and proper tumor model. [ABSTRACT FROM PUBLISHER]

Published
2012
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24. Talus ile calcaneus arasındaki eklem yüzlerinin incelenmesi

Author

Altinkaya, Handan, Soysal, Handan, and Anatomi Ana Bilim Dalı

Subjects
Morphology, Morfoloji
Abstract

ÖZET Talus ile calcaneus arasındaki eklem yüzlerinin incelenmesi Bu çalışmada, talus ile calcaneus arasında oluşan ekleme katılan eklem yüzlerinde görülen farklılıklar incelenmiştir. Bu amaçla, 134 adet (61 talus ve 73 calcaneus) kuru kemik ve 54 adet (27 talus ve 27 calcaneus) taze (kadavradan elde edilen) kemik üzerinde çalışılmıştır. İncelenen kemikler üzerinde eklem yüzlerinin sayısı ve şekli dikkate alınarak sınıflandırma yapıldı. Kuru kemiklerde, talus ve calcaneus'a ait eklem yüzleri ayrı ayrı değerlendirilip sınıflandırılırken, cinsiyeti belirli taze kemiklere ait eklem yüzlerinin sınıflandırılmas ın da ise aynı ayağa ait talus ve calcaneus çifti birlikte değerlendirilmiştir. Bulgular kuru kemik ve taze kemikler olarak iki grup halinde sunuldu. Kuru kemiklere ait sınıflandırmada 61 adet talus'a ait eklem yüzleri 5 ana tip altında toplanmıştır. Bu 5 tipten, tip I: 25, tip II: 22, tip III: 6, tip IV: 4 ve tip V: 2 talus'tan oluşurken, 73 adet calcaneus'a ait eklem yüzleri ise 4 ana tip altında toplanmış olup, tip I; 46, tip II; 26 ve tip III; 1. calcaneus'tan oluşmaktaydı. Taze kemiklere ait sınıflandırmada, 3 ana tip mevcuttu. Değerlendirmede aynı ayağa ait talus ve calcaneus çifti birlikte kullanılmıştır. Buna göre Tip I: 17 çift (12 erkek ve 5 kadın), Tip II: 6 çift (2 erkek ve 4 kadın), Tip III: 4 çift (1 erkek ve 3 kadın) kemikte görüldü. Elde edilen sonuçlar literatür bilgileri ışığında tartışıldı. Anahtar kelimeler: human, talus, calcaneus, facies articularis. SUMMARY The examination of joint facets between tali and calcanei In this study, the joint facets which forms the articulation between talus and calcaneus has been examined. For this purpose, 134 (61 tali, 73 calcanei) dry and 54 (27 tali and 27 calcanei) fresh bones (from cadavers) have been studied. The classification performed according to the joint facets and formations of this articulation. While the joint facets of talus and calcaneus have been evaluated one by one in dry bones, the classification of talus and calcaneus pairs from fresh cadavers have been evaluated together. Findings of dry and fresh bones were presented in two groups. In the classification of dry bones, the joint facets of 6 1 talus have been grouped in 5 main types. Type I has 25, type II has 22, type III has 6, type IV has 4 and type V has 2 bones. In the classification of joint facets of 73 calcanei have been grouped in 4 main types. In these 4 types; 46 of type I, 26 of type II and 1 of type III have been observed. In the classification of fresh bones, 3 main types have been observed. Talus and calcaneus pairs of the same foot has been evaluated. According to this, 17 pairs (12 males and 5 females) of type I, 6 pairs (2 male and 4 female) of type II and 4 pairs ( 1 male and 3 female) of type III were observed. Key words: human, talus, calcaneus, joint facets. 61

Published
2002

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