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10. Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life

Author

Cangiano, Biagio, Giusti, Emanuele, Premoli, Caterina, Soranna, Davide, Vitale, Giovanni, Grottoli, Silvia, Cambria, Valeria, Mantovani, Giovanna, Mungari, Roberta, Maffei, Pietro, Dassie, Francesca, Giampietro, Antonella, Chiloiro, Sabrina, Tanda, Maria Laura, Ippolito, Silvia, Cannavò, Salvatore, Ragonese, Marta, Zambon, Antonella, Persani, Luca, Fatti, Letizia Maria, and Scacchi, Massimo

Published
2022
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13. Progression of joint and psychological complications in acromegaly and their association with treatments and disease control

Author

Cangiano, Biagio, primary, Premoli, Caterina, additional, Soranna, Davide, additional, Vitale, Giovanni, additional, Grottoli, Silvia, additional, Cambria, Valeria, additional, Maffei, Pietro, additional, Dassie, Francesca, additional, Cannavo, Salvatore, additional, Ragonese, Marta, additional, Zambon, Antonella, additional, Persani, Luca, additional, Fatti, Letizia, additional, and Scacchi, Massimo, additional

Published
2024
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14. RESIDENCE AT HIGH ALTITUDE IS ASSOCIATED WITH LOWER CONVENTIONAL AND AMBULATORY BLOOD PRESSURE THAN LIVING AT SEA LEVEL IN THE GENERAL POPULATION OF PERU. HIGHCARE-LAPS STUDY

Author

Bilo, Grzegorz, primary, Villafuerte, Francisco C., additional, Zanotti, Lucia, additional, Soranna, Davide, additional, Nava, Sara, additional, Rusconi, Valentina, additional, Pengo, Martino F., additional, Croce, Alessandro, additional, Lombardi, Carolina, additional, Macarlupu, Jose Luis, additional, Bermudez, Daniela, additional, Sosa, Jose’ Manuel, additional, Carcamo, Cesar P., additional, Zambon, Antonella, additional, and Parati, Gianfranco, additional

Published
2024
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15. SEX RELATED DIFFERENCES IN BLOOD PRESSURE VARIABILITY IN HYPERTENSIVE PATIENTS: CV-PREVITAL STUDY

Author

Croce, Alessandro, primary, Bilo, Grzegorz, additional, Pengo, Martino, additional, Soranna, Davide, additional, Sucapuca, Richard, additional, Amato, Franca, additional, Favè, Marta, additional, Marino, Antonietta, additional, Pellegrinelli, Veronica, additional, Molteni, Serena, additional, Nardin, Elisa, additional, Parisi, Marco, additional, Romeo, Claudia, additional, Losa, Lorenzo, additional, Saccà, Angelo Maria, additional, De Virgiliis, Giorgia, additional, Colella, Chiara, additional, Zambon, Antonella, additional, Ferrara, Pietro, additional, and Parati, Gianfranco, additional

Published
2024
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19. Muscle Strength and Phase Angle Are Potential Markers for the Efficacy of Multidisciplinary Weight-Loss Program in Patients with Sarcopenic Obesity.

Author

Brunani, Amelia, Brenna, Ettore, Zambon, Antonella, Soranna, Davide, Donini, Lorenzo Maria, Busetto, Luca, Bertoli, Simona, Capodaglio, Paolo, and Cancello, Raffaella

Subjects
MUSCLE strength, MUSCLE mass, RESISTANCE training, WEIGHT loss, BIOELECTRIC impedance
Abstract

Background/Objectives: Traditional weight-loss methods often result in the loss of both fat and muscle mass. For individuals with sarcopenic obesity (SO), additional muscle loss can exacerbate sarcopenia, leading to further declines in muscle strength and function, ultimately worsening quality of life. To mitigate this risk, weight-loss strategies should emphasize the preservation and building of muscle mass through adequate protein intake and tailored resistance training. This study aimed to evaluate changes in SO status following a 4-week multidisciplinary weight-loss intervention program in hospitalized patients with obesity. Methods: This study included adult patients with obesity (BMI > 30 kg/m2, aged 18–90 years). The SO diagnosis was performed using the handgrip strength (HGS) test and skeletal muscle mass (SMM) by bioelectrical impedance analysis (BIA) according to ESPEN/EASO-2022 guidelines. Results: A total of 2004 patients were enrolled, 64.8% female, with a mean age of 56 (±14) years and a BMI of 40.7 (±6.48) kg/m2. SO was present in 9.38% (188 patients) at baseline. At discharge, 80 patients (42.55%) were no longer classified as sarcopenic and showed significant improvements in HGS. The likelihood of resolving SO was not modified in patients with only phase angle (PhA) improvement (p-value = 0.141). Patients with HGS increment had a 65% probability to be No-SO at discharge and this probability, with the concomitant PhA increment, rose to 93% (p-value < 0.0001), indicating that functional changes and good nutrition status are crucial in improvement of SO. Muscle mass (MM) and SMMI remained unchanged in the studied cohort. Conclusions: Improvements in HGS and the PhA are potential markers for the efficacy of weight-loss programs tailored to patients with SO. These findings suggest that specific interventions focusing on these markers could be beneficial in managing SO patients. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Cerebrospinal fluid and blood neurofilament light chain levels in amyotrophic lateral sclerosis and frontotemporal degeneration: A meta‐analysis.

Author

Verde, Federico, Licaj, Sara, Soranna, Davide, Ticozzi, Nicola, Silani, Vincenzo, and Zambon, Antonella

Abstract

Background and purpose: Neurofilament light chain (NFL) has been shown to be increased in amyotrophic lateral sclerosis (ALS) and, to a lesser extent, in frontotemporal dementia (FTD). A meta‐analysis of NFL in ALS and FTD was performed. Methods: Available studies comparing cerebrospinal fluid and blood NFL levels in ALS versus neurologically healthy controls (NHCs), other neurological diseases (ONDs) and ALS mimics, as well as in FTD and related entities (behavioural variant of FTD and frontotemporal lobar degeneration syndromes) versus NHCs, ONDs and other dementias were evaluated. Results: In ALS, both cerebrospinal fluid and blood levels of NFL were higher compared to other categories. In FTD, behavioural variant of FTD and frontotemporal lobar degeneration syndromes, NFL levels were consistently higher compared to NHCs; however, several comparisons with ONDs and other dementias did not demonstrate significant differences. Discussion: Amyotrophic lateral sclerosis is characterized by higher NFL levels compared to most other conditions. In contrast, NFL is not as good at discriminating FTD from other dementias. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Interventions aimed to increase average 24-h systolic blood pressure reduce blood pressure drops in patients with reflex syncope and orthostatic intolerance

Author

Groppelli, Antonella, primary, Rivasi, Giulia, additional, Fedorowski, Artur, additional, de Lange, Frederik J, additional, Russo, Vincenzo, additional, Maggi, Roberto, additional, Capacci, Marco, additional, Nawaz, Sara, additional, Comune, Angelo, additional, Bianchi, Lorenzo, additional, Zambon, Antonella, additional, Soranna, Davide, additional, Ungar, Andrea, additional, Parati, Gianfranco, additional, and Brignole, Michele, additional

Published
2024
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25. Vitamin D and COVID-19 severity and related mortality: a prospective study in Italy

Author

Campi, Irene, Gennari, Luigi, Merlotti, Daniela, Mingiano, Christian, Frosali, Alessandro, Giovanelli, Luca, Torlasco, Camilla, Pengo, Martino F., Heilbron, Francesca, Soranna, Davide, Zambon, Antonella, Di Stefano, Marta, Aresta, Carmen, Bonomi, Marco, Cangiano, Biagio, Favero, Vittoria, Fatti, Letizia, Perego, Giovanni Battista, Chiodini, Iacopo, Parati, Gianfranco, and Persani, Luca

Published
2021
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28. Development of a questionnaire on nutritional knowledge for the obese hospitalized patient: the NUTRIKOB questionnaire

Author

Mambrini, Sara Paola, primary, Soranna, Davide, additional, Averna, Eva, additional, Di Guglielmo, Giulia, additional, Lucchetti, Elisa, additional, Tinozzi, Tiziana, additional, Vinci, Calogero, additional, Barbieri, Valerio, additional, Zambon, Antonella, additional, Bertoli, Simona, additional, and Scacchi, Massimo, additional

Published
2023
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30. Towards an individualized management of pubertal induction in girls with hypogonadism: insight into the best replacement outcomes from a large multicentre registry

Author

Rodari, Giulia, primary, Federici, Silvia, additional, Todisco, Tommaso, additional, Ubertini, Graziamaria, additional, Cattoni, Alessandro, additional, Pagano, Marta, additional, Giacchetti, Federico, additional, Profka, Eriselda, additional, Citterio, Valeria, additional, Messetti, Dario, additional, Collini, Valentina, additional, Soranna, Davide, additional, Carbone, Erika, additional, Arosio, Maura, additional, Mantovani, Giovanna, additional, Persani, Luca, additional, Cappa, Marco, additional, Bonomi, Marco, additional, and Giavoli, Claudia, additional

Published
2023
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31. The Impact of Covid-19 Lockdown on Pubertal Onset in A Second Level Center

Author

Goggi, Giovanni, primary, Moro, Mirella, additional, Chila, Alessandro, additional, Fatti, Letizia, additional, Cangiano, Biagio, additional, Federici, SIlvia, additional, Galazzi, Elena, additional, Carbone, Erika, additional, Soranna, Davide, additional, Vezzoli, Valeria, additional, Persani, Luca, additional, and Bonomi, Marco, additional

Published
2023
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33. Long-term effects of GH therapy in adult patients with Prader- Willi syndrome: a longitudinal study

Author

Grugni Graziano, Sartorio Alessandro, Soranna Davide, Zambon Antonella, Grugni Lucia, Zampino Giuseppe, and Crinò Antonio

Subjects
Prader-Willi syndrome, adults, GH deficiency, GH therapy, obesity
Abstract

Introduction: Prader-Willi syndrome (PWS) is a complex disorder resulting from the failure of expression of paternal alleles in the PWS region of chromosome 15. The PWS phenotype resembles that observed in the classic non-PWS GH deficiency (GHD), including short stature, excessive fat mass, and reduced muscle mass. To date, a small number of studies on the long-term effects of GH treatment are available in adult subjects with PWS. Methods: In this longitudinal study, 12 obese subjects with PWS (GHD/non-GHD 6/6) were treated for a median of 17 years, with a median GH dose of 0.35 mg/ day. The median age was 27.1 years. Anthropometric, body composition, hormonal, biochemical, and blood pressure variables were analyzed in all subjects. Results: Waist circumference was significantly lower at the end of the treatment period (p-value=0.0449), while body mass index (BMI) did not differ significantly. Compared to the baseline, a highly significant reduction of Fat Mass % (FM%) was observed (p-value=0.0005). IGF-I SDS values significantly increased during GH therapy (p-value=0.0005). A slight impairment of glucose homeostasis was observed after GH therapy, with an increase in the median fasting glucose levels, while insulin, HOMA-IR, and HbA1c values remained unchanged. Considering GH secretory status, both subjects with and without GHD showed a significant increase in IGF-I SDS and a reduction of FM% after GH therapy (pvalue= 0.0313 for all). Discussion: Our results indicate that long-term GH treatment has beneficial effects on body composition and body fat distribution in adults with PWS associated with obesity. However, the increase in glucose values during GH therapy should be considered, and continuous surveillance of glucose metabolism is mandatory during long-term GH therapy, especially in subjects with obesity.

Published
2023
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34. Nocturnal hypoxemia, blood pressure, vascular status and chronic mountain sickness in the highest city in the world

Author

Perger, Elisa, Baillieul, Sébastien, Esteve, François, Pichon, Aurélien, Bilo, Gzregorz, Soranna, Davide, Doutreleau, Stéphane, Savina, Yann, Ulliel-Roche, Mathilde, Brugniaux, Julien V., Stauffer, Emeric, Oberholzer, Laura, Howe, Connor, Hannco, Ivan, Lombardi, Carolina, Tamisier, Renaud, Pepin, Jean-Louis, Verges, Samuel, Parati, Gianfranco, Perger, E, Baillieul, S, Esteve, F, Pichon, A, Bilo, G, Soranna, D, Doutreleau, S, Savina, Y, Ulliel-Roche, M, Brugniaux, J, Stauffer, E, Oberholzer, L, Howe, C, Hannco, I, Lombardi, C, Tamisier, R, Pepin, J, Verges, S, and Parati, G

Subjects
Male, Blood Pressure, General Medicine, Altitude Sickness, Pulse Wave Analysis, Carotid Intima-Media Thickness, sleep disordered breathing, Cross-Sectional Studies, Sleep Apnea Syndromes, Chronic Disease, Hypertension, Quality of Life, Humans, blood pressure variability, chronic mountain sickne, Hypoxia, sleep apnoea, high-altitude
Abstract

Chronic mountain sickness (CMS) is a condition characterized by excessive erythrocytosis in response to chronic hypobaric hypoxia. CMS frequently triggers cardiorespiratory diseases such as pulmonary hypertension and right or left heart failure. Ambient hypoxia might be further amplified night-time by intermittent hypoxia related to sleep-disordered breathing (SDB) so that sleep disturbance may be an important feature of CMS. Our aim was to characterize in a cross-sectional study nocturnal hypoxaemia, SDB, blood pressure (BP), arterial stiffness and carotid intima-media thickness (CIMT) in highlanders living at extreme altitude. Men aged 18 to 55 years were prospectively recruited. Home sleep apnoea test, questionnaires (short-form health survey; Montreal cognitive assessment; Pittsburgh Sleep Questionnaire Index and the Insomnia severity index), 24-h ambulatory BP monitoring, CIMT and arterial stiffness were evaluated in 3 groups: i) Andean lowlanders (sea-level); ii) highlanders living at 3,800 m and iii) highlanders living at 5,100 m. Analyses were conducted in sub-groups according to 1) CMS severity 2) healthy subjects living at the three different altitude. Ninety-two males were evaluated at their living altitudes. Among the 54 highlanders living at 5,100 m, subjects with CMS showed lower mean nocturnal oxygen saturation (SpO2), SpO2 nadir, lower pulse wave velocity and higher nocturnal BP variability than those with no-CMS. Lower nocturnal SpO2 nadir was associated with higher CMS severity (ß= −0.14, p=.009). Among the 55 healthy subjects, healthy highlanders at 5,100 m were characterized by lower scores on quality of life and sleep quality scales and lower mean SpO2 compared to lowlanders. Lower nocturnal SpO2 and higher nocturnal BP variability are associated with CMS severity in individuals living permanently at high altitude. The role of lower SpO2 and higher nocturnal BP variability in the cardiovascular progression of CMS and in the overall prognosis of the disease need to be evaluated in further studies.

Published
2022

35. Impact of severe secondary tricuspid regurgitation on rest and exercise hemodynamics of patients with heart failure and a preserved left ventricular ejection fraction

Author

Baratto, Claudia, primary, Caravita, Sergio, additional, Corbetta, Giorgia, additional, Soranna, Davide, additional, Zambon, Antonella, additional, Dewachter, Céline, additional, Gavazzoni, Mara, additional, Heilbron, Francesca, additional, Tomaselli, Michele, additional, Radu, Noela, additional, Perelli, Francesco Paolo, additional, Perego, Giovanni Battista, additional, Vachiéry, Jean-Luc, additional, Parati, Gianfranco, additional, Badano, Luigi P., additional, and Muraru, Denisa, additional

Published
2023
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36. Corrigendum to “Syncope in hypertrophic cardiomyopathy (part I): An updated systematic review and meta-analysis” [International Journal of Cardiology Volume 357, 15 June 2022, Pages 88–94].

Author

Mascia, Giuseppe, primary, Crotti, Lia, additional, Groppelli, Antonella, additional, Canepa, Marco, additional, Merlo, Andrea Carlo, additional, Benenati, Stefano, additional, Di Donna, Paolo, additional, Bona, Roberta Della, additional, Soranna, Davide, additional, Zambon, Antonella, additional, Porto, Italo, additional, Olivotto, Iacopo, additional, Parati, Gianfranco, additional, Brignole, Michele, additional, and Cecchi, Franco, additional

Published
2023
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37. Impact of severe secondary tricuspid regurgitation on rest and exercise hemodynamics of patients with heart failure and a preserved left ventricular ejection fraction

Author

Baratto, Claudia, Caravita, Sergio, Corbetta, Giorgia, Soranna, Davide, Zambon, Antonella, Dewachter, Céline, Gavazzoni, Mara, Heilbronn, François, Tomaselli, Michele, Radu, Noela, Perelli, Francesco Paolo, Battista Perego, Giovanni, Vachiery, Jean-Luc, Parati, Gianfranco, Badano, Luigi, Muraru, Denisa, Baratto, Claudia, Caravita, Sergio, Corbetta, Giorgia, Soranna, Davide, Zambon, Antonella, Dewachter, Céline, Gavazzoni, Mara, Heilbronn, François, Tomaselli, Michele, Radu, Noela, Perelli, Francesco Paolo, Battista Perego, Giovanni, Vachiery, Jean-Luc, Parati, Gianfranco, Badano, Luigi, and Muraru, Denisa

Abstract

Background Both secondary tricuspid regurgitation (STR) and heart failure with preserved ejection fraction (HFpEF) are relevant public health problems in the elderly population, presenting with potential overlaps and sharing similar risk factors. However, the impact of severe STR on hemodynamics and cardiorespiratory adaptation to exercise in HFpEF remains to be clarified. Aim To explore the impact of STR on exercise hemodynamics and cardiorespiratory adaptation in HFpEF. Methods We analyzed invasive hemodynamics and gas-exchange data obtained at rest and during exercise from HFpEF patients with severe STR (HFpEF-STR), compared with 1:1 age-, sex-, and body mass index (BMI)- matched HFpEF patients with mild or no STR (HFpEF-controls). Results Twelve HFpEF with atrial-STR (mean age 72 years, 92% females, BMI 28 Kg/m 2 ) and 12 HFpEF-controls patients were analyzed. HFpEF-STR had higher ( p < 0.01) right atrial pressure than HFpEF-controls both at rest (10 ± 1 vs. 5 ± 1 mmHg) and during exercise (23 ± 2 vs. 14 ± 2 mmHg). Despite higher pulmonary artery wedge pressure (PAWP) at rest in HFpEF-STR than in HFpEF-controls (17 ± 2 vs. 11 ± 2, p = 0.04), PAWP at peak exercise was no more different (28 ± 2 vs. 29 ± 2). Left ventricular transmural pressure and cardiac output (CO) increased less in HFpEF-STR than in HFpEF-controls (interaction p -value < 0.05). This latter was due to lower stroke volume (SV) values both at rest (48 ± 9 vs. 77 ± 9 mL, p < 0.05) and at peak exercise (54 ± 10 vs. 93 ± 10 mL, p < 0.05). Despite these differences, the two groups of patients laid on the same oxygen consumption isophlets because of the increased peripheral oxygen extraction in HFpEF-STR ( p < 0.01). We found an inverse relationship between pulmonary vascular resistance and SV, both at rest and at peak exercise ( R 2 = 0.12 and 0.19, respectively). Conclusions Severe STR complicating HFpEF impairs SV and CO reserve, leading to pulmonary vascular de-recruitment and relati, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2023

41. PS-P07-3: EFFICACY AND SAFETY OF NIFEDIPINE GASTROINTESTINAL THERAPEUTIC SYSTEM VERSUS RAMIPRIL IN CHINESE AND EUROPEAN PATIENTS WITH HYPERTENSION

Author

Zhang, Wei, primary, Liu, Changyuan, additional, Grzegorz, Bilo, additional, Soranna, Davide, additional, Zamabon, Antonella, additional, Kyriakoulis, Konstantinos, additional, Kollias, Anastasios, additional, Ceravolo, Isabella, additional, Cassago, Silvia, additional, Pengo, Martino, additional, Stergiou, George, additional, Parati, Gianfranco, additional, and Wang, Jiguang, additional

Published
2023
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42. PS-C12-8: BLOOD PRESSURE VARIABILITY IN PREVIOUSLY UNTREATED HYPERTENSIVE PATIENTS RANDOMIZED TO NIFEDIPINE GITS OR RAMIPRIL. REVERENT STUDY

Author

Bilo, Grzegorz, primary, Kyriakoulis, Konstantinos, additional, Liu, Chang Yuan, additional, Soranna, Davide, additional, Ceravolo, Isabella, additional, Cassago, Silvia, additional, Zhang, Wei, additional, Kollias, Anastasios, additional, Pengo, Martino F, additional, Zambon, Antonella, additional, Wang, Jiguang, additional, Stergiou, George S, additional, and Parati, Gianfranco, additional

Published
2023
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49. Feasibility of Blood Pressure Measurement With a Wearable (Watch‐Type) Monitor During Impending Syncopal Episodes

Author

Groppelli, Antonella, primary, Rafanelli, Martina, additional, Testa, Giuseppe Dario, additional, Agusto, Samuele, additional, Rivasi, Giulia, additional, Ungar, Andrea, additional, Carbone, Erika, additional, Soranna, Davide, additional, Zambon, Antonella, additional, Brignole, Michele, additional, and Parati, Gianfranco, additional

Published
2022
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50. Association between hypotension during 24 h ambulatory blood pressure monitoring and reflex syncope: the SynABPM 1 study

Author

Rivasi, Giulia, primary, Groppelli, Antonella, additional, Brignole, Michele, additional, Soranna, Davide, additional, Zambon, Antonella, additional, Bilo, Grzegorz, additional, Pengo, Martino, additional, Sharad, Bashaaer, additional, Hamrefors, Viktor, additional, Rafanelli, Martina, additional, Testa, Giuseppe Dario, additional, Rice, Ciara, additional, Kenny, Rose Anne, additional, Sutton, Richard, additional, Ungar, Andrea, additional, Fedorowski, Artur, additional, and Parati, Gianfranco, additional

Published
2022
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