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2. Vepafestinib is a pharmacologically advanced RET-selective inhibitor with high CNS penetration and inhibitory activity against RET solvent front mutations

Author

Miyazaki, Isao, Odintsov, Igor, Ishida, Keiji, Lui, Allan J. W., Kato, Masanori, Suzuki, Tatsuya, Zhang, Tom, Wakayama, Kentaro, Kurth, Renate I., Cheng, Ryan, Fujita, Hidenori, Delasos, Lukas, Vojnic, Morana, Khodos, Inna, Yamada, Yukari, Ishizawa, Kota, Mattar, Marissa S., Funabashi, Kaoru, Chang, Qing, Ohkubo, Shuichi, Yano, Wakako, Terada, Ryuichiro, Giuliano, Claudio, Lu, Yue Christine, Bonifacio, Annalisa, Kunte, Siddharth, Davare, Monika A., Cheng, Emily H., de Stanchina, Elisa, Lovati, Emanuela, Iwasawa, Yoshikazu, Ladanyi, Marc, and Somwar, Romel

Published
2023
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5. Combination Therapy With MDM2 and MEK Inhibitors Is Effective in Patient-Derived Models of Lung Adenocarcinoma With Concurrent Oncogenic Drivers and MDM2 Amplification

Author

Elkrief, Arielle, Odintsov, Igor, Markov, Vladimir, Caeser, Rebecca, Sobczuk, Pawel, Tischfield, Sam E., Bhanot, Umesh, Vanderbilt, Chad M., Cheng, Emily H., Drilon, Alexander, Riely, Gregory J., Lockwood, William W., de Stanchina, Elisa, Tirunagaru, Vijaya G., Doebele, Robert C., Quintanal-Villalonga, Álvaro, Rudin, Charles M., Somwar, Romel, and Ladanyi, Marc

Published
2023
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6. Author Correction: Vepafestinib is a pharmacologically advanced RET-selective inhibitor with high CNS penetration and inhibitory activity against RET solvent front mutations

Author

Miyazaki, Isao, Odintsov, Igor, Ishida, Keiji, Lui, Allan J. W., Kato, Masanori, Suzuki, Tatsuya, Zhang, Tom, Wakayama, Kentaro, Kurth, Renate I., Cheng, Ryan, Fujita, Hidenori, Delasos, Lukas, Vojnic, Morana, Khodos, Inna, Yamada, Yukari, Ishizawa, Kota, Mattar, Marissa S., Funabashi, Kaoru, Chang, Qing, Ohkubo, Shuichi, Yano, Wakako, Terada, Ryuichiro, Giuliano, Claudio, Lu, Yue Christine, Bonifacio, Annalisa, Kunte, Siddharth, Davare, Monika A., Cheng, Emily H., de Stanchina, Elisa, Lovati, Emanuela, Iwasawa, Yoshikazu, Ladanyi, Marc, and Somwar, Romel

Published
2023
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8. Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells

Author

Johnson, Fraser D., Ferrarone, John, Liu, Alvin, Brandstädter, Christina, Munuganti, Ravi, Farnsworth, Dylan A., Lu, Daniel, Luu, Jennifer, Sihota, Tianna, Jansen, Sophie, Nagelberg, Amy, Shi, Rocky, Forcina, Giovanni C., Zhang, Xu, Cheng, Grace S.W., Spencer Miko, Sandra E., de Rappard-Yuswack, Georgia, Sorensen, Poul H., Dixon, Scott J., Guha, Udayan, Becker, Katja, Djaballah, Hakim, Somwar, Romel, Varmus, Harold, Morin, Gregg B., and Lockwood, William W.

Published
2022
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15. Overcoming clinical resistance to EZH2 inhibition using rational epigenetic combination therapy

Author

Kazansky, Yaniv, primary, Cameron, Daniel, additional, Mueller, Helen S., additional, Demarest, Phillip, additional, Zaffaroni, Nadia, additional, Arrighetti, Noemi, additional, Zuco, Valentina, additional, Kuwahara, Yasumichi, additional, Somwar, Romel, additional, Ladanyi, Marc, additional, Qu, Rui, additional, de Stanchina, Elisa, additional, Dela Cruz, Filemon S., additional, Kung, Andrew L., additional, Gounder, Mrinal M., additional, and Kentsis, Alex, additional

Published
2024
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16. Prevalence and Therapeutic Targeting of High Level ERBB2 Amplification in Non-Small Cell Lung Cancer

Author

Odintsov, Igor, primary, Makarem, Maisam, additional, Nishino, Mizuki, additional, Bachert, Sara Emily, additional, Zhang, Tom, additional, LoPiccolo, Jaclyn, additional, Paweletz, Cloud P., additional, Gokhale, Prafulla C., additional, Ivanova, Elena, additional, Saldanha, Aisha, additional, Rudin, Charles M., additional, Lockwood, William W., additional, Ladanyi, Marc, additional, Somwar, Romel, additional, Jänne, Pasi A., additional, and Sholl, Lynette M., additional

Published
2023
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17. Resistance to TRK inhibition mediated by convergent MAPK pathway activation

Author

Cocco, Emiliano, Schram, Alison M., Kulick, Amanda, Misale, Sandra, Won, Helen H., Yaeger, Rona, Razavi, Pedram, Ptashkin, Ryan, Hechtman, Jaclyn F., Toska, Eneda, Cownie, James, Somwar, Romel, Shifman, Sophie, Mattar, Marissa, Selçuklu, S. Duygu, Samoila, Aliaksandra, Guzman, Sean, Tuch, Brian B., Ebata, Kevin, de Stanchina, Elisa, Nagy, Rebecca J., Lanman, Richard B., Houck-Loomis, Brian, Patel, Juber A., Berger, Michael F., Ladanyi, Marc, Hyman, David M., Drilon, Alexander, and Scaltriti, Maurizio

Published
2019
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19. HER4 and EGFR activate cell signaling in NRG1 fusion-driven cancers: implications for HER2/HER3-specific vs. pan-HER targeting strategies

Author

Udagawa, Hibiki, primary, Nilsson, Monique B., additional, Robichaux, Jacqulyne P., additional, He, Junqin, additional, Poteete, Alissa, additional, Jiang, Hong, additional, Heeke, Simon, additional, Elamin, Yasir Y., additional, Shibata, Yuji, additional, Matsumoto, Shingo, additional, Yoh, Kiyotaka, additional, Okazaki, Shogo, additional, Masuko, Takashi, additional, Odintsov, Ignor, additional, Somwar, Romel, additional, Ladanyi, Marc, additional, Goto, Koichi, additional, and Heymach, John V., additional

Published
2023
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23. Abstract 6127: MDM2 inhibition in combination with MEK inhibition in pre-clinical models of lung adenocarcinomas with MDM2 amplification

Author

Elkrief, Arielle, primary, Markov, Vladimir, additional, Quintanal-Villalonga, Álvaro, additional, Caeser, Rebecca, additional, Sobczuk, Pawel, additional, Cheng, Emily, additional, Drilon, Alexander, additional, Riely, Gregory J., additional, Lockwood, William W., additional, de Stanchina, Elisa, additional, Rudin, Charles M., additional, Odintsov, Igor, additional, and Somwar, Romel, additional

Published
2023
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24. Supplementary Table from Zenocutuzumab, a HER2xHER3 Bispecific Antibody, Is Effective Therapy for Tumors Driven by NRG1 Gene Rearrangements

Author

Schram, Alison M., primary, Odintsov, Igor, primary, Espinosa-Cotton, Madelyn, primary, Khodos, Inna, primary, Sisso, Whitney J., primary, Mattar, Marissa S., primary, Lui, Allan J.W., primary, Vojnic, Morana, primary, Shameem, Sara H., primary, Chauhan, Thrusha, primary, Torrisi, Jean, primary, Ford, Jim, primary, O'Connor, Marie N., primary, Geuijen, Cecile A.W., primary, Schackmann, Ron C.J., primary, Lammerts van Bueren, Jeroen J., primary, Wasserman, Ernesto, primary, de Stanchina, Elisa, primary, O'Reilly, Eileen M., primary, Ladanyi, Marc, primary, Drilon, Alexander, primary, and Somwar, Romel, primary

Published
2023
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25. Abstract 4007: Efficacy of vepafestinib in preclinical models of RET fusion-driven sarcoma models

Author

Odintsov, Igor, primary, Cheng, Ryan C., additional, Lui, Allan J., additional, Zhang, Tom, additional, Lu, Yue C., additional, Kurth, Renate I., additional, Vojnic, Morana, additional, Khodos, Inna, additional, Chang, Qing, additional, Chen, Kevin, additional, Giuliano, Claudio, additional, Bonifacio, Annalisa, additional, Miyazaki, Isao, additional, Stanchina, Elisa de, additional, Lovati, Emanuela, additional, Ladanyi, Marc, additional, and Somwar, Romel, additional

Published
2023
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26. Supplementary Figure from Zenocutuzumab, a HER2xHER3 Bispecific Antibody, Is Effective Therapy for Tumors Driven by NRG1 Gene Rearrangements

Author

Schram, Alison M., primary, Odintsov, Igor, primary, Espinosa-Cotton, Madelyn, primary, Khodos, Inna, primary, Sisso, Whitney J., primary, Mattar, Marissa S., primary, Lui, Allan J.W., primary, Vojnic, Morana, primary, Shameem, Sara H., primary, Chauhan, Thrusha, primary, Torrisi, Jean, primary, Ford, Jim, primary, O'Connor, Marie N., primary, Geuijen, Cecile A.W., primary, Schackmann, Ron C.J., primary, Lammerts van Bueren, Jeroen J., primary, Wasserman, Ernesto, primary, de Stanchina, Elisa, primary, O'Reilly, Eileen M., primary, Ladanyi, Marc, primary, Drilon, Alexander, primary, and Somwar, Romel, primary

Published
2023
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27. Data from Zenocutuzumab, a HER2xHER3 Bispecific Antibody, Is Effective Therapy for Tumors Driven by NRG1 Gene Rearrangements

Author

Schram, Alison M., primary, Odintsov, Igor, primary, Espinosa-Cotton, Madelyn, primary, Khodos, Inna, primary, Sisso, Whitney J., primary, Mattar, Marissa S., primary, Lui, Allan J.W., primary, Vojnic, Morana, primary, Shameem, Sara H., primary, Chauhan, Thrusha, primary, Torrisi, Jean, primary, Ford, Jim, primary, O'Connor, Marie N., primary, Geuijen, Cecile A.W., primary, Schackmann, Ron C.J., primary, Lammerts van Bueren, Jeroen J., primary, Wasserman, Ernesto, primary, de Stanchina, Elisa, primary, O'Reilly, Eileen M., primary, Ladanyi, Marc, primary, Drilon, Alexander, primary, and Somwar, Romel, primary

Published
2023
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33. Data from Response to ERBB3-Directed Targeted Therapy in NRG1-Rearranged Cancers

Author

Drilon, Alexander, primary, Somwar, Romel, primary, Mangatt, Biju P., primary, Edgren, Henrik, primary, Desmeules, Patrice, primary, Ruusulehto, Anja, primary, Smith, Roger S., primary, Delasos, Lukas, primary, Vojnic, Morana, primary, Plodkowski, Andrew J., primary, Sabari, Joshua, primary, Ng, Kenneth, primary, Montecalvo, Joseph, primary, Chang, Jason, primary, Tai, Huichun, primary, Lockwood, William W., primary, Martinez, Victor, primary, Riely, Gregory J., primary, Rudin, Charles M., primary, Kris, Mark G., primary, Arcila, Maria E., primary, Matheny, Christopher, primary, Benayed, Ryma, primary, Rekhtman, Natasha, primary, Ladanyi, Marc, primary, and Ganji, Gopinath, primary

Published
2023
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34. Supplementary Figures from Response to ERBB3-Directed Targeted Therapy in NRG1-Rearranged Cancers

Author

Drilon, Alexander, primary, Somwar, Romel, primary, Mangatt, Biju P., primary, Edgren, Henrik, primary, Desmeules, Patrice, primary, Ruusulehto, Anja, primary, Smith, Roger S., primary, Delasos, Lukas, primary, Vojnic, Morana, primary, Plodkowski, Andrew J., primary, Sabari, Joshua, primary, Ng, Kenneth, primary, Montecalvo, Joseph, primary, Chang, Jason, primary, Tai, Huichun, primary, Lockwood, William W., primary, Martinez, Victor, primary, Riely, Gregory J., primary, Rudin, Charles M., primary, Kris, Mark G., primary, Arcila, Maria E., primary, Matheny, Christopher, primary, Benayed, Ryma, primary, Rekhtman, Natasha, primary, Ladanyi, Marc, primary, and Ganji, Gopinath, primary

Published
2023
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35. Supplementary Table from Response to ERBB3-Directed Targeted Therapy in NRG1-Rearranged Cancers

Author

Drilon, Alexander, primary, Somwar, Romel, primary, Mangatt, Biju P., primary, Edgren, Henrik, primary, Desmeules, Patrice, primary, Ruusulehto, Anja, primary, Smith, Roger S., primary, Delasos, Lukas, primary, Vojnic, Morana, primary, Plodkowski, Andrew J., primary, Sabari, Joshua, primary, Ng, Kenneth, primary, Montecalvo, Joseph, primary, Chang, Jason, primary, Tai, Huichun, primary, Lockwood, William W., primary, Martinez, Victor, primary, Riely, Gregory J., primary, Rudin, Charles M., primary, Kris, Mark G., primary, Arcila, Maria E., primary, Matheny, Christopher, primary, Benayed, Ryma, primary, Rekhtman, Natasha, primary, Ladanyi, Marc, primary, and Ganji, Gopinath, primary

Published
2023
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36. Supplementary Methods from Response to ERBB3-Directed Targeted Therapy in NRG1-Rearranged Cancers

Author

Drilon, Alexander, primary, Somwar, Romel, primary, Mangatt, Biju P., primary, Edgren, Henrik, primary, Desmeules, Patrice, primary, Ruusulehto, Anja, primary, Smith, Roger S., primary, Delasos, Lukas, primary, Vojnic, Morana, primary, Plodkowski, Andrew J., primary, Sabari, Joshua, primary, Ng, Kenneth, primary, Montecalvo, Joseph, primary, Chang, Jason, primary, Tai, Huichun, primary, Lockwood, William W., primary, Martinez, Victor, primary, Riely, Gregory J., primary, Rudin, Charles M., primary, Kris, Mark G., primary, Arcila, Maria E., primary, Matheny, Christopher, primary, Benayed, Ryma, primary, Rekhtman, Natasha, primary, Ladanyi, Marc, primary, and Ganji, Gopinath, primary

Published
2023
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48. Figure S1 from Therapeutic Potential of NTRK3 Inhibition in Desmoplastic Small Round Cell Tumor

Author

Ogura, Koichi, primary, Somwar, Romel, primary, Hmeljak, Julija, primary, Magnan, Heather, primary, Benayed, Ryma, primary, Momeni Boroujeni, Amir, primary, Bowman, Anita S., primary, Mattar, Marissa S., primary, Khodos, Inna, primary, de Stanchina, Elisa, primary, Jungbluth, Achim, primary, Asher, Marina, primary, Odintsov, Igor, primary, Hartono, Alifiani B., primary, LaQuaglia, Michael P., primary, Slotkin, Emily, primary, Pratilas, Christine A., primary, Lee, Sean Bong, primary, Spraggon, Lee, primary, and Ladanyi, Marc, primary

Published
2023
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50. Supplementary Figure S3 from The Anti-HER3 mAb Seribantumab Effectively Inhibits Growth of Patient-Derived and Isogenic Cell Line and Xenograft Models with Oncogenic NRG1 Fusions

Author

Odintsov, Igor, primary, Lui, Allan J.W., primary, Sisso, Whitney J., primary, Gladstone, Eric, primary, Liu, Zebing, primary, Delasos, Lukas, primary, Kurth, Renate I., primary, Sisso, Exequiel M., primary, Vojnic, Morana, primary, Khodos, Inna, primary, Mattar, Marissa S., primary, de Stanchina, Elisa, primary, Leland, Shawn M., primary, Ladanyi, Marc, primary, and Somwar, Romel, primary

Published
2023
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