Author: "SOLANS, R." - Searchworks@Jio Institute Digital Library Search Results

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1. Vasculitis de mediano vaso. Vasculitis necrotizantes: panarteritis nodosa y vasculitis ANCA asociadas. Enfermedad de Kawasaki

Author: Mestre, J., Martínez Valle, F., and Solans, R.
Published: 2017
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2. How are we treating our systemic patients with primary Sjögren syndrome? Analysis of 1120 patients

Author: Gheitasi, H., Kostov, B., Solans, R., Fraile, G., Suárez-Cuervo, C., Casanovas, A., Rascón, F.J., Qanneta, R., Pérez-Alvarez, R., Ripoll, M., Akasbi, M., Pinilla, B., Bosch, J.A., Nava-Mateos, J., Díaz-López, B., Morera-Morales, M.L., Retamozo, S., Ramos-Casals, M., and Brito-Zerón, P.
Published: 2015
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3. SARS-CoV-2 infection in patients with primary Sjögren syndrome: Characterization and outcomes of 51 patients

Author: Medicina i Cirurgia, Universitat Rovira i Virgili, Brito-Zerón P; Brito-Zerón P; Melchor S; Seror R; Seror R; Priori R; Priori R; Solans R; Solans R; Kostov B; Kostov B; Baldini C; Carubbi F; Carubbi F; Callejas JL; Guisado-Vasco P; Hernández-Molina G; Hernández-Molina G; Pasoto SG; Pasoto SG; Valim V; Valim V; Sisó-Almirall A; Sisó-Almirall A; Mariette X; Carreira P; Ramos-Casals M; Brito-Zerón P; Morcillo C; Flores-Chávez A; Acar-Denizli N; Horvath IF; Szanto A; Tarr T; Mandl T; Olsson P; Li X; Xu B; Baldini C; Bombardieri S; Gottenberg JE; Gandolfo S; De Vita S; Giardina F; Sánchez-Guerrero J; Kruize AA; Hinrichs A; Isenberg D; Rischmueller M; Downie-Doyle S; Kwok SK; Park SH; Nordmark G; Suzuki Y; Kawano M; Giacomelli R; Devauchelle-Pensec V; Saraux A; Hofauer B; Knopf A; Bootsma H; Vissink A; Morel J; Vollenveider C; Atzeni F; Retamozo S; Moça Trevisano V; Armagan B; Kilic L; Kalyoncu U; Consani-Fernández S; Callejas JL; López-Dupla M; Pérez-Alvarez R; Akasbi M; Sánchez I, Medicina i Cirurgia, Universitat Rovira i Virgili, and Brito-Zerón P; Brito-Zerón P; Melchor S; Seror R; Seror R; Priori R; Priori R; Solans R; Solans R; Kostov B; Kostov B; Baldini C; Carubbi F; Carubbi F; Callejas JL; Guisado-Vasco P; Hernández-Molina G; Hernández-Molina G; Pasoto SG; Pasoto SG; Valim V; Valim V; Sisó-Almirall A; Sisó-Almirall A; Mariette X; Carreira P; Ramos-Casals M; Brito-Zerón P; Morcillo C; Flores-Chávez A; Acar-Denizli N; Horvath IF; Szanto A; Tarr T; Mandl T; Olsson P; Li X; Xu B; Baldini C; Bombardieri S; Gottenberg JE; Gandolfo S; De Vita S; Giardina F; Sánchez-Guerrero J; Kruize AA; Hinrichs A; Isenberg D; Rischmueller M; Downie-Doyle S; Kwok SK; Park SH; Nordmark G; Suzuki Y; Kawano M; Giacomelli R; Devauchelle-Pensec V; Saraux A; Hofauer B; Knopf A; Bootsma H; Vissink A; Morel J; Vollenveider C; Atzeni F; Retamozo S; Moça Trevisano V; Armagan B; Kilic L; Kalyoncu U; Consani-Fernández S; Callejas JL; López-Dupla M; Pérez-Alvarez R; Akasbi M; Sánchez I
Abstract: Objective: To analyse the prognosis and outcomes of SARS-CoV-2 infection in patients with primary SS. Methods: We searched for patients with primary SS presenting with SARS-CoV-2 infection (defined following and according to the European Centre for Disease Prevention and Control guidelines) among those included in the Big Data Sjögren Registry, an international, multicentre registry of patients diagnosed according to the 2002/2016 classification criteria. Results: A total of 51 patients were included in the study (46 women, mean age at diagnosis of infection of 60 years). According to the number of patients with primary SS evaluated in the Registry (n = 8211), the estimated frequency of SARS-CoV-2 infection was 0.62% (95% CI 0.44, 0.80). All but two presented with symptoms suggestive of COVID-19, including fever (82%), cough (57%), dyspnoea (39%), fatigue/myalgias (27%) and diarrhoea (24%), and the most frequent abnormalities included raised lactate dehydrogenase (LDH) (88%), CRP (81%) and D-dimer (82%) values, and lymphopenia (70%). Infection was managed at home in 26 (51%) cases and 25 (49%) required hospitalization (five required admission to ICU, four died). Compared with patients managed at home, those requiring hospitalization had higher odds of having lymphopenia as laboratory abnormality (adjusted OR 21.22, 95% CI 2.39, 524.09). Patients with comorbidities had an older age (adjusted OR 1.05, 95% CI 1.00, 1.11) and showed a risk for hospital admission six times higher than those without (adjusted OR 6.01, 95% CI 1.72, 23.51) in the multivariate analysis. Conclusion: Baseline comorbidities were a key risk factor for a more complicated COVID-19 in patients with primary SS, with higher rates of hospitalization and poor outcomes in comparison with patients without co
Published: 2021

4. Childhood-onset of primary Sjögren’s syndrome: phenotypic characterization at diagnosis of 158 children

Author: Ramos-Casals, M., Acar-Denizli, N., Vissink, A., Brito-Zeron, P., Li, X., Carubbi, F., Priori, R., Toplak, N., Baldini, C., Faugier-Fuentes, E., Kruize, A. A., Mandl, T., Tomiita, M., Gandolfo, S., Hashimoto, K., Hernandez-Molina, G., Hofauer, B., Mendieta-Zeron, S., Rasmussen, A., Sandhya, P., Sene, D., Trevisani, V. F. M., Isenberg, D., Sundberg, E., Pasoto, S. G., Sebastian, A., Suzuki, Y., Retamozo, S., Xu, B., Giacomelli, R., Gattamelata, A., Bizjak, M., Bombardieri, S., Loor-Chavez, R. -E., Hinrichs, A., Olsson, P., Bootsma, H., Lieberman, S. M., Kostov, B., Horvath, I. -F., Szanto, A., Seror, R., Mariette, X., Kvarnstrom, M., Wahren-Herlenius, M., Praprotnik, S., Solans, R., Nordmark, G., Hammenfors, D., Brun, J. G., Gheita, T. A., Atzeni, F., Armagan, B., Kilic, L., Kalyoncu, U., Nakamura, T., Takagi, Y., Consani, S., Solorzano, F. O., Translational Immunology Groningen (TRIGR), Personalized Healthcare Technology (PHT), Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, and Universitat Politècnica de Catalunya. ADBD - Anàlisi de Dades Complexes per a les Decisions Empresarials
Subjects: Male, Systemic disease, Anti-nuclear antibody, Epidemiology, Autoimmune diseases, Matemàtiques i estadística::Matemàtica aplicada a les ciències [Àrees temàtiques de la UPC], Disease, Severity of Illness Index, Parotid Gland, Medicine, CLASSIFICATION CRITERIA, Pharmacology (medical), Registries, Age of Onset, biology, 92 Biology and other natural sciences::92B Mathematical biology in general [Classificació AMS], Dry eyes, Phenotype, Sjogren's syndrome, Female, epidemiology, Antibody, medicine.symptom, PAROTITIS, medicine.medical_specialty, Biomatemàtica, Adolescent, 62 Statistics::62D05 Sampling theory, sample surveys [Classificació AMS], Childhood, Paediatrics, Humans, Sjogren's Syndrome, paediatrics, AGE, Rheumatology, Peripheral nerve, Rheumatoid factor, autoimmune diseases, Sampling (Statistics), Primary Sjögren Syndrome, childhood, Biomathematics, Matemàtiques i estadística::Estadística aplicada::Estadística biosanitària [Àrees temàtiques de la UPC], business.industry, CLINICAL-FEATURES, medicine.disease, Dry mouth, Dermatology, stomatognathic diseases, biology.protein, Sjogren’s syndrome, CONSENSUS, business, Mostreig (Estadística), Parotitis
Abstract: Objectives To characterize the phenotypic presentation at diagnosis of childhood-onset primary SS. Methods The Big Data Sjögren Project Consortium is an international, multicentre registry using worldwide data-sharing cooperative merging of pre-existing clinical SS databases from the five continents. For this study, we selected those patients in whom the disease was diagnosed below the age of 19 years according to the fulfilment of the 2002/2016 classification criteria. Results Among the 12 083 patients included in the Sjögren Big Data Registry, 158 (1.3%) patients had a childhood-onset diagnosis (136 girls, mean age of 14.2 years): 126 (80%) reported dry mouth, 111 (70%) dry eyes, 52 (33%) parotid enlargement, 118/122 (97%) positive minor salivary gland biopsy and 60/64 (94%) abnormal salivary US study, 140/155 (90%) positive ANA, 138/156 (89%) anti-Ro/La antibodies and 86/142 (68%) positive RF. The systemic EULAR Sjögren’s syndrome disease activity index (ESSDAI) domains containing the highest frequencies of active patients included the glandular (47%), articular (26%) and lymphadenopathy (25%) domains. Patients with childhood-onset primary SS showed the highest mean ESSDAI score and the highest frequencies of systemic disease in 5 (constitutional, lymphadenopathy, glandular, cutaneous and haematological) of the 12 ESSDAI domains, and the lowest frequencies in 4 (articular, pulmonary, peripheral nerve and CNS) in comparison with patients with adult-onset disease. Conclusions Childhood-onset primary SS involves around 1% of patients with primary SS, with a clinical phenotype dominated by sicca features, parotid enlargement and systemic disease. Age at diagnosis plays a key role in modulating the phenotypic expression of the disease.
Published: 2021
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5. IDENTIFICACIÓN DE NUEVAS REGIONES GENÉTICAS ASOCIADAS A LA ARTERITIS DE CÉLULAS GIGANTES MEDIANTE GWAS.

Author: Borrego Yaniz, Gonzalo, Ortiz-Fernández, Lourdes, Kerick, Martin, Solans, R, Cid, María C., Hernández-Rodríguez, José, Castañeda, S., Ortego-Centeno, Norberto, Salvarani, Carlo, González-Gay, M. A., Morgan, Ann W., Martín, Javier, Márquez, Ana, Borrego Yaniz, Gonzalo, Ortiz-Fernández, Lourdes, Kerick, Martin, Solans, R, Cid, María C., Hernández-Rodríguez, José, Castañeda, S., Ortego-Centeno, Norberto, Salvarani, Carlo, González-Gay, M. A., Morgan, Ann W., Martín, Javier, and Márquez, Ana
Published: 2022

6. Systemic activity and mortality in primary Sjögren syndrome: predicting survival using the EULAR-SS Disease Activity Index (ESSDAI) in 1045 patients

Author: Brito-Zerón, P, Kostov, B, Solans, R, Fraile, G, Suárez-Cuervo, C, Casanovas, A, Rascón, F J, Qanneta, R, Pérez-Alvarez, R, Ripoll, M, Akasbi, M, Pinilla, B, Bosch, J A, Nava-Mateos, J, Díaz-López, B, Morera-Morales, M L, Gheitasi, H, Retamozo, S, and Ramos-Casals, M
Published: 2016
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7. Influence of the IL17A locus in giant cell arteritis susceptibility

Author: Márquez, A, Hernández-Rodríguez, J, Cid, M C, Solans, R, Castañeda, S, Fernández-Contreras, M E, Ramentol, M, Morado, I C, Narváez, J, Gómez-Vaquero, C, Martínez-Taboada, V M, Ortego-Centeno, N, Sopeña, B, Monfort, J, García-Villanueva, M J, Caminal-Montero, L, de Miguel, E, Blanco, R, Palm, O, Molberg, O, Latus, J, Braun, N, Moosig, F, Witte, T, Beretta, L, Santaniello, A, Pazzola, G, Boiardi, L, Salvarani, C, González-Gay, M A, and Martín, J
Published: 2014
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8. SARS-CoV-2 infection in patients with primary Sjögren syndrome: characterization and outcomes of 51 patients

Author: Brito-Zerón, Pilar, Melchor, Sheila, Seror, Raphaèle, Priori, Roberta, Solans, Roser, Kostov, Belchin, Baldini, Chiara, Carubbi, Francesco, Callejas, Jose Luis, Guisado-Vasco, Pablo, Hernández-Molina, Gabriela, Pasoto, Sandra G, Valim, Valeria, Sisó-Almirall, Antoni, Mariette, Xavier, Carreira, Patricia, Ramos-Casals, Manuel, Brito-Zerón, P, Morcillo, C, Flores-Chávez, A, Ramos-Casals, M, Acar-Denizli, N, Horvath, I F, Szanto, A, Tarr, T, Seror, R, Mariette, X, Mandl, T, Olsson, P, Li, X, Xu, B, Baldini, C, Bombardieri, S, Gottenberg, J E, Gandolfo, S, De Vita, S, Priori, R, Giardina, F, Hernandez-Molina, G, Sánchez-Guerrero, J, Kruize, A A, Hinrichs, A, Valim, V, Isenberg, D, Solans, R, Rischmueller, M, Downie-Doyle, S, Kwok, S-K, Park, S-H, Nordmark, G, Suzuki, Y, Kawano, M, Giacomelli, R, Devauchelle-Pensec, V, Saraux, A, Hofauer, B, Knopf, A, Bootsma, H, Vissink, A, Morel, J, Vollenveider, C, Atzeni, F, Retamozo, S, Moça Trevisano, V, Armagan, B, Kilic, L, Kalyoncu, U, Pasoto, S G, Kostov, B, Sisó-Almirall, A, Consani-Fernández, S, Carubbi, F, Callejas, J L, López-Dupla, M, Pérez-Alvarez, R, Akasbi, M, Guisado-Vasco, P, Sánchez, I, Hospital Universitario 12 de Octubre [Madrid], EULAR standing committee of People with Arthritis/Rheumatism in Europe (PARE), H. CIMA-Sanitas, Barcelona, CELLEX-IDIBAPS Department of Autoimmune Diseases, Barcelona, Instituto Mexicano del Seguro Social [Mexico City, Mexico] (IMSS), Universidad de Colima [Mexico], Hospital Clinic [Barcelona, Spain], İstanbul Üniversitesi, İstanbul, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary, MTA-Debreceni Egyetem, Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes (IMVA-HB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Center for Immunology of Viral Infections and Autoimmune Diseases, Le Kremlin Bicêtre, Skåne University Hospital [Malmö, Suède], Stockholm University, Wuhan University [China], Pisa University Hospital, Nuclear Medicine Unit, Humanitas Gavazzeni, Bergamo, Italy, University Hospitals, Strasbourg, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán - National Institute of Medical Science and Nutrition Salvador Zubiran [Mexico], Federal University of Espírito Santo, University Hospital Vall d’Hebròn [Barcelona, Spain], Lymphocytes B, Autoimmunité et Immunothérapies (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-LabEX IGO Immunothérapie Grand Ouest, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Génétique Moléculaire de Montpellier (IGMM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut d'Investigaciones Biomèdiques August Pi i Sunye (IDIBAPS), Università degli studi di Palermo - University of Palermo, Hospitales Universitarios de Granada/Universidad de Granada, Hospital Universitario Quironsalud, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Rheumatology Unit, Department of Internal Medicine, University of Palermo, Palermo, Italy, and Michel, Geneviève
Subjects: Male, medicine.medical_specialty, Multivariate analysis, [SDV.IMM] Life Sciences [q-bio]/Immunology, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Comorbidity, Laboratory abnormality, comorbidities, outcomes, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Risk Factors, Internal medicine, medicine, Humans, In patient, Pharmacology (medical), 030212 general & internal medicine, Registries, Risk factor, Primary Sjögren Syndrome, AcademicSubjects/MED00360, ComputingMilieux_MISCELLANEOUS, 030203 arthritis & rheumatology, business.industry, SARS-CoV-2, COVID-19, Primary SS, SARS-Cov-2, Middle Aged, medicine.disease, 3. Good health, Hospitalization, Sjogren's Syndrome, [SDV.IMM]Life Sciences [q-bio]/Immunology, Original Article, Female, business
Abstract: Objective To analyse the prognosis and outcomes of SARS-CoV-2 infection in patients with primary SS. Methods We searched for patients with primary SS presenting with SARS-CoV-2 infection (defined following and according to the European Centre for Disease Prevention and Control guidelines) among those included in the Big Data Sjögren Registry, an international, multicentre registry of patients diagnosed according to the 2002/2016 classification criteria. Results A total of 51 patients were included in the study (46 women, mean age at diagnosis of infection of 60 years). According to the number of patients with primary SS evaluated in the Registry (n = 8211), the estimated frequency of SARS-CoV-2 infection was 0.62% (95% CI 0.44, 0.80). All but two presented with symptoms suggestive of COVID-19, including fever (82%), cough (57%), dyspnoea (39%), fatigue/myalgias (27%) and diarrhoea (24%), and the most frequent abnormalities included raised lactate dehydrogenase (LDH) (88%), CRP (81%) and D-dimer (82%) values, and lymphopenia (70%). Infection was managed at home in 26 (51%) cases and 25 (49%) required hospitalization (five required admission to ICU, four died). Compared with patients managed at home, those requiring hospitalization had higher odds of having lymphopenia as laboratory abnormality (adjusted OR 21.22, 95% CI 2.39, 524.09). Patients with comorbidities had an older age (adjusted OR 1.05, 95% CI 1.00, 1.11) and showed a risk for hospital admission six times higher than those without (adjusted OR 6.01, 95% CI 1.72, 23.51) in the multivariate analysis. Conclusion Baseline comorbidities were a key risk factor for a more complicated COVID-19 in patients with primary SS, with higher rates of hospitalization and poor outcomes in comparison with patients without comorbidities.
Published: 2020
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9. Identification of the PTPN22 functional variant R620W as susceptibility genetic factor for giant cell arteritis

Author: Serrano, A, Márquez, A, Mackie, S L, Carmona, F D, Solans, R, Miranda-Filloy, J A, Hernández-Rodríguez, J, Cid, M C, Castañeda, S, Morado, IC, Narváez, J, Blanco, R, Sopeña, B, García-Villanueva, M J, Monfort, J, Ortego-Centeno, N, Unzurrunzaga, A, Marí-Alfonso, B, Sánchez-Martín, J, de Miguel, E, Magro, C, Raya, E, Braun, N, Latus, J, Molberg, O, Lie, B A, Moosig, F, Witte, T, Morgan, A W, González-Gay, M A, and Martín, J
Published: 2013
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10. Relapse rate and renal prognosis in ANCA-associated vasculitis according to long-term ANCA patterns

Author: Oristrell, J, primary, Loureiro-Amigo, J, additional, Solans, R, additional, Valenzuela, M P, additional, Monsálvez, V, additional, Segarra, A, additional, Amengual, M J, additional, Marín, A, additional, Feijoo, C, additional, and Tolosa, C, additional
Published: 2020
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11. SAT0274 DESCRIPTIVE ANALYSIS OF FLARES DURING THE LONG-TERM FOLLOW-UP OF PATIENTS WITH BEHÇET’S DISEASE INCLUDED IN REGEB COHORT

Author: Rodríguez Carballeira, M., primary, Solans, R., additional, Ríos Fernández, R., additional, Escalante, B., additional, Maure, B., additional, Fernández, A., additional, Hurtado, R., additional, Boldova, R., additional, and Espinosa, G., additional
Published: 2020
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12. Systemic phenotype related to primary Sjögren's syndrome in 279 patients carrying isolated anti-La/SSB antibodies

Author: Acar-Denizli, N., Horvath, I. -F, Mandl, T., Priori, R., Vissink, A., Hernandez-Molina, G., Armagan, B., Praprotnik, S., Sebastian, A., Bartoloni, E., Rischmueller, M., Pasoto, S. G., Nordmark, Gunnel, Nakamura, H., Fernandes Moca Trevisani, V., Retamozo, S., Carsons, S. E., Maure-Noia, B., Sanchez-Berna, I., Lopez-Dupla, M., Fonseca-Aizpuru, E., Melchor Diaz, S., Vazquez, M., Diaz Cuiza, P. E., de Miguel Campo, B., Ng, W. -F, Rasmussen, A., Dong, X., Li, X., Baldini, C., Seror, R., Gottenberg, J. -E, Kruize, A. A., Sandhya, P., Gandolfo, S., Kwok, S. -K, Kvarnstrom, M., Solans, R., Sene, D., Suzuki, Y., Isenberg, D. A., Valim, V., Hofauer, B., Giacomelli, R., Devauchelle-Pensec, V., Atzeni, F., Gheita, T. A., Morel, J., Izzo, R., Kalyoncu, U., Szanto, A., Olsson, P., Bootsma, H., Ramos-Casals, M., Kostov, B., Brito-Zeron, P., Acar-Denizli, N., Horvath, I. -F, Mandl, T., Priori, R., Vissink, A., Hernandez-Molina, G., Armagan, B., Praprotnik, S., Sebastian, A., Bartoloni, E., Rischmueller, M., Pasoto, S. G., Nordmark, Gunnel, Nakamura, H., Fernandes Moca Trevisani, V., Retamozo, S., Carsons, S. E., Maure-Noia, B., Sanchez-Berna, I., Lopez-Dupla, M., Fonseca-Aizpuru, E., Melchor Diaz, S., Vazquez, M., Diaz Cuiza, P. E., de Miguel Campo, B., Ng, W. -F, Rasmussen, A., Dong, X., Li, X., Baldini, C., Seror, R., Gottenberg, J. -E, Kruize, A. A., Sandhya, P., Gandolfo, S., Kwok, S. -K, Kvarnstrom, M., Solans, R., Sene, D., Suzuki, Y., Isenberg, D. A., Valim, V., Hofauer, B., Giacomelli, R., Devauchelle-Pensec, V., Atzeni, F., Gheita, T. A., Morel, J., Izzo, R., Kalyoncu, U., Szanto, A., Olsson, P., Bootsma, H., Ramos-Casals, M., Kostov, B., and Brito-Zeron, P.
Abstract: Objective: To evaluate the systemic phenotype associated with the presence of isolated anti-La/SSB antibodies in a large international registry of patients with primary Sjogren's syndrome (pSS) fulfilling the 2002 classification criteria. Methods: The Big Data Sjogren Project Consortium is an international, multicentre registry created in 2014. Baseline clinical information from leading centres on clinical research in SS of the 5 continents was collected. Combination patterns of anti-Ro/SSA-La/SSB antibodies at the time of diagnosis defined the following four immunological phenotypes: double positive (combined Ro/SSA and La/SSB,) isolated anti-Ro/SSA, isolated anti-La/SSB, and immunonegative. Results: The cohort included 12,084 patients (11,293 females, mean 52.4 years) with recorded ESSDAI scores available. Among them, 279 (2.3%) had isolated anti-La/SSB antibodies. The mean total ESSDAI score at diagnosis of patients with pSS carrying isolated anti-La/SSB was 6.0, and 80.4% of patients had systemic activity (global ESSDAI score >= 1) at diagnosis. The domains with the highest frequency of active patients were the biological (42.8%), glandular (36.8%) and articular (31.2%) domains. Patients with isolated anti-La/ SSB showed a higher frequency of active patients in all ESSDAI domains but two (articular and peripheral nerve) in comparison with immune-negative patients, and even a higher absolute frequency in six clinical ESSDAI domains in comparison with patients with isolated anti-Ro/SSA. In addition, patients with isolated anti-La/SSB showed a higher frequency of active patients in two ESSDAI domains (pulmonary and glandular) with respect to the most active immunological subset (double-positive antibodies). Meanwhile, systemic activity detected in patients with isolated anti-La/SSB was overwhelmingly low. Even in ESSDAI domains where patients with isolated anti-La/SSB had the highest frequencies of systemic activity (lymphadenopathy and muscular), the percentage
Published: 2020

13. Antimitochondrial antibodies in patients with chronic hepatitis C virus infection: description of 18 cases and review of the literature

Author: Ramos-Casals, M., Pares, A., Jara, L.-J., Solans, R., Viñas, O., Vázquez, P., Sánchez-Tapias, J.-M., Rodés, J., and Font, J.
Published: 2005

14. Mortality and prognostic factors in Spanish patients with systemic sclerosis

Author: Simeón, C. P., Armadans, L., Fonollosa, V., Solans, R., Selva, A., Villar, M., Lima, J., Vaqué, J., and Vilardell, M.
Published: 2003

15. Churg–Strauss syndrome: outcome and long-term follow-up of 32 patients. Comment on the article by Solans et al.

Author: Solans, R., Bosch, J. A., Pérez-Bocanegra, C., Selva, A., Huguet, P., Alijotas, J., Orriols, R., Armadans, L., and Vilardell, M.
Published: 2002

16. Montelukast and Churg-Strauss syndrome

Author: Solans, R, Bosch, J A, Selva, A, Orriols, R, and Vilardell, M
Published: 2002

17. Churg–Strauss syndrome: outcome and long-term follow-up of 32 patients

Author: Solans, R., Bosch, J. A., Pérez-Bocanegra, C., Selva, A., Huguet, P., Alijotas, J., Orriols, R., Armadans, L., and Vilardell, M.
Published: 2001

18. How immunological profle drives clinical phenotype of primary Sjögren’s syndrome at diagnosis: analysis of 10,500 patients (Sjögren Big Data Project)

Author: Brito Zerón, Pilar, Acar Denizli, Nihan, Ng, Wan Fai, Zeher, Margit, Rasmussen, Astrid, Mandl, Thomas, Seror, Raphaele, Xiaolin, Li, Baldini, Chiara, Gottenberg, Jaques, Danda, Debashish, Quartuccio, Luca, Priori, Roberta, Hernandez Molina, Gabriela, Armagan, Berkan, Kruize, Aike, Kwok, Seung Ki, Kvarnström, Marika, Praprotnik, Sonja, Sene, Damien, Bartoloni, Elena, Solans, R., Rischmueller, M., Suzuki, Y., Isenberg, D. A., Valim, V., Wiland, P., Nordmark, G., Fraile, G., and Retamozo, Maria Soledad
Subjects: Salivary gland biopsy, purl.org/becyt/ford/3.2 [https], Cryoglobulinaemia, Primary Sjögren’s syndrome, Hypocomplementaemia, purl.org/becyt/ford/3 [https], Ro/La autoantibodies
Abstract: To evaluate the influence of the main immunological markers on the disease phenotype at diagnosis in a large international cohort of patients with primary Sjögren´s syndrome (SjS).METHODS:The Big Data Sjögren Project Consortium is an international, multicentre registry created in 2014. As a first step, baseline clinical information from leading centres on clinical research in SjS of the 5 continents was collected. The centres shared a harmonised data architecture and conducted cooperative online efforts in order to refine collected data under the coordination of a big data statistical team. Inclusion criteria were the fulfillment of the 2002 classification criteria. Immunological tests were carried out using standard commercial assays.RESULTS:By January 2018, the participant centres had included 10,500 valid patients from 22 countries. The cohort included 9,806 (93%) women and 694 (7%) men, with a mean age at diagnosis of primary SjS of 53 years, mainly White (78%) and included from European countries (71%). The frequency of positive immunological markers at diagnosis was 79.3% for ANA, 73.2% for anti-Ro, 48.6% for RF, 45.1% for anti- La, 13.4% for low C3 levels, 14.5% for low C4 levels and 7.3% for cryoglobulins. Positive autoantibodies (ANA, Ro, La) correlated with a positive result in salivary gland biopsy, while hypocomplementaemia and especially cryoglo-bulinaemia correlated with systemic activity (mean ESSDAI score of 17.7 for cryoglobulins, 11.3 for low C3 and 9.2 for low C4, in comparison with 3.8 for negative markers). The immunological markers with a great number of statistically-significant associations (p
Published: 2018

19. Influence of epidemiology and ethnicity on systemic expression of primary Sjögren syndrome in 9974 patients

Author: Retamozo, Soledad, Acar-Denizli, Nihan, Fai Ng, W, Zeher, M, Rasmussen, A, Seror, Raphaèle, Li, X, Baldini, C, Gottenberg, Jacques-Eric, Danda, D, Quartuccio, Luca, Priori, R, Hernandez-Molina, G, Armagan, B, Kruize, Aike A, Kwok, S-K, Wahren-Herlenius, Marie, Praprotnik, Sonja, Sene, Damien, Bartoloni, Elena, Solans, R., Rischmueller, Maureen, Mandl, T, Suzuki, Y, Isenberg, David, Valim, V, Wiland, Piotr, Nordmark, Gunnel, Fraile, G, Bootsma, Hendrika, Nakamura, T, Giacomelli, R., Devauchelle-Pensec, Valérie, Hofauer, Benedikt, Bombardieri, Michele, Fernandes Moça Trevisani, Virginia, Hammenfors, D, S.G., Pasoto, Gheita, Tamer A, Atzeni, Fabiola, Morel, Jacques, Vollenveider, Cristina, Brito-Zerón, Pilar, Ramos-Casals, Manel, Rheumatology Unit, Cordoba (Institute University of Biomedical Sciences University of Cordoba (IUCBC), Hospital Clinic (IDIBAPS), INICSA, UNC, CONICED, Cordoba, Mimar Sinan Üniversitesi, Newcastle University [Newcastle], University of Debrecen [Hungary], Oklahoma Medical Research Foundation, Oklahoma Medical Research Foundation (OMRF), Université Paris Sud (Paris 11), Anhui Provincial Hosp, University of Pisa - Università di Pisa, Les Hôpitaux Universitaires de Strasbourg (HUS), Christian Medical College & Hospital, Rheumatology Clinic, Udine (DSMB), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], INCMNSS, Mexico, Hacettepe University = Hacettepe Üniversitesi, University Medical Center [Utrecht], Catholic University of Korea, Unit of Experimental Rheumatology, Stockhom (Department of Medicine), Department of Rheumatology, University Medical Centre, Service de médecine interne [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Università degli Studi di Perugia (UNIPG), Vall d'Hebron University Hospital [Barcelona], The University of Western Australia (UWA), Lund University, Malmö University Hospital, Kanazawa Medical University, Centre for Rheumatology - London, Federal University of Espírito Santo, Wroclaw Medical University, Uppsala Universitet [Uppsala], Hospital Universitario Ramón y Cajal [Madrid], Universidad de Alcalá - University of Alcalá (UAH), Department of Rheumatology and Clinical Immunology Groningen (Dep Rheum - GRONINGEN), University Medical Center Groningen [Groningen] (UMCG), Nagasaki University, University of L'Aquila [Italy] (UNIVAQ), CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Hals-Nasen-Ohrenklinik und Poliklinik, Munchen, Queen Mary University London, Université Fédérale de São Paulo (Unifesp), Haukeland University Hospital, University of Bergen (UiB), Hospital das Clinicas, University of Sao Paulo School of Medicine, Cairo University - Faculty of Medicine, Messina and Milan Univ, Milan, Service de Rhumatologie [CHU de Montpellier], CHU Montpellier, German Hosp, Buenos Aires, H. CIMA-Sanitas, Barcelona, and Michel, Geneviève
Subjects: [SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2018

20. Sjögren big data project, the first example of data sharing in autoimmune diseases: analysis of 10475 worldwide patients

Author: Retamozo, Soledad, Acar-Denizli, Nihan, Fai Ng, W, Zeher, M, Rasmussen, A, Mandl, T, Seror, Raphaèle, Li, X, Baldini, C, Gottenberg, Jacques-Eric, Danda, D, Quartuccio, Luca, A, Minniti, Hernandez-Molina, Gabriela, Kalyoncu, Umut, Kruize, Aike A, Kwok, S-K, Wahren-Herlenius, Marie, Praprotnik, Sonja, Sene, Damien, Bartolini, E, Solans, R., Rischmueller, Maureen, Suzuki, Y, Isenberg, David, Valim, V, Wiland, Piotr, Nordmark, Gunnel, Fraile, G, Bootsma, Hendrika, Nakamura, T, Giacomelli, R., Devauchelle-Pensec, Valérie, Hofauer, Benedikt, Bombardieri, Michèle, Fernandes Moça Trevisani, Virginia, Hammenfors, D, S.G., Pasoto, Gheita, Tamer A, Atzeni, Fabiola, Morel, Jacques, Vollenveider, Cristina, Brito-Zerón, Pilar, Ramos-Casals, Manuel, Hospital Clinic (IDIBAPS), Rheumatology Unit, Cordoba (Institute University of Biomedical Sciences University of Cordoba (IUCBC), INICSA, UNC, CONICED, Cordoba, Mimar Sinan Üniversitesi, Newcastle University [Newcastle], University of Debrecen [Hungary], Oklahoma Medical Research Foundation, Oklahoma Medical Research Foundation (OMRF), Lund University, Malmö University Hospital, Université Paris Sud (Paris 11), Anhui Provincial Hosp, University of Pisa - Università di Pisa, Les Hôptaux universitaires de Strasbourg (HUS), CHU Strasbourg, Christian Medical College & Hospital, Rheumatology Clinic, Udine (DSMB), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán - National Institute of Medical Science and Nutrition Salvador Zubiran [Mexico], Hacettepe University = Hacettepe Üniversitesi, University Medical Center [Utrecht], Catholic University of Korea, Unit of Experimental Rheumatology, Stockhom (Department of Medicine), Department of Rheumatology, University Medical Centre, Service de médecine interne [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université dePerugia, Vall d'Hebron University Hospital [Barcelona], The University of Western Australia (UWA), Kanazawa University (KU), Centre for Rheumatology - London, Federal University of Espírito Santo, Wroclaw Medical University, Department of Medical Sciences, Hospital Universitario Ramón y Cajal [Madrid], Universidad de Alcalá - University of Alcalá (UAH), Department of Rheumatology and Clinical Immunology Groningen (Dep Rheum - GRONINGEN), University Medical Center Groningen [Groningen] (UMCG), Nagasaki University, University of L'Aquila [Italy] (UNIVAQ), CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Hals-Nasen-Ohrenklinik und Poliklinik, Munchen, The William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London (QMUL), Université Fédérale de São Paulo (Unifesp), Haukeland University Hospital, University of Bergen (UiB), Hospital das Clinicas, University of Sao Paulo School of Medicine, Cairo University - Faculty of Medicine, Messina and Milan Univ, Milan, Service de Rhumatologie [CHU de Montpellier], CHU Montpellier, German Hosp, Buenos Aires, H. CIMA-Sanitas, Barcelona, CELLEX-IDIBAPS Department of Autoimmune Diseases, Barcelona, and Michel, Geneviève
Subjects: [SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2018

21. A north-south worldwide gradient in systemic activity of primary Sjögren syndrome: increased severe disease in patients from southern countries

Author: Retamozo, Soledad, Acar-Denizli, Nihan, Fai Ng, W, Zeher, M, Rasmussen, A, Seror, Raphaele, LI, Xiaogai, Baldini, C, Gottenberg, Jacques-Eric, Danda, D, Quartuccio, Luca, Priori, Roberta, Hernandez-Molina, G, Armagan, B, Kruize, Aike A, Kwok, S-K, Wahren-Herlenius, Marie, Praprotnik, Sonja, Sene, D, Bartoloni, Elena, Solans, R., Rischmueller, Maureen, Mandl, T, Suzuki, Y, Isenberg, David A, Valim, V, Wiland, Piotr, Nordmark, Gunnel, Fraile, G, Bootsma, Hendrika, Nakamura, T, Giacomelli, R., Devauchelle-Pensec, Valérie, Hofauer, Benedikt, Bombardieri, Michele, Trevisani, Virginia Fernandes Moça, Hammenfors, D, S.G., Pasoto, Gheita, Tamer A, Atzeni, Fabiola, Morel, J, Vollenveider, Cristina, Ramos-Casals, Manel, Rheumatology Unit, Cordoba (Institute University of Biomedical Sciences University of Cordoba (IUCBC), Hospital Clinic (IDIBAPS), INICSA, UNC, CONICED, Cordoba, Mimar Sinan Üniversitesi, Newcastle University [Newcastle], University of Debrecen [Hungary], Oklahoma Medical Research Foundation, Oklahoma Medical Research Foundation (OMRF), Center for Immunology of Viral Infections and Autoimmune Diseases, Le Kremlin Bicêtre, Anhui Provincial Hosp, University of Pisa - Università di Pisa, Immuno-Rhumatologie Moléculaire, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Christian Medical College & Hospital, Rheumatology Clinic, Udine (DSMB), UO Complessa Reumatologia, Rome, INCMNSS, Mexico, Hacettepe University = Hacettepe Üniversitesi, University Medical Center [Utrecht], Catholic University of Korea, Unit of Experimental Rheumatology, Stockhom (Department of Medicine), Department of Rheumatology, University Medical Centre, Université Paris Diderot - Paris 7 (UPD7), Università degli Studi di Perugia (UNIPG), Vall d'Hebron University Hospital [Barcelona], The University of Western Australia (UWA), Lund University, Malmö University Hospital, Kanazawa Medical University, Centre for Rheumatology - London, Federal University of Espírito Santo, Wroclaw Medical University, Uppsala Universitet [Uppsala], Hospital Universitario Ramón y Cajal [Madrid], Universidad de Alcalá - University of Alcalá (UAH), University of Groningen [Groningen], Nagasaki University, University of L'Aquila [Italy] (UNIVAQ), CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Hals-Nasen-Ohrenklinik und Poliklinik, Munchen, Queen Mary University London, Federal University of Sao Paulo (Unifesp), Haukeland University Hospital, University of Bergen (UIB), Hospital das Clinicas, University of Sao Paulo School of Medicine, Cairo University - Faculty of Medicine, Messina and Milan Univ, Milan, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), German Hosp, Buenos Aires, Laboratory of Autoimmune Diseases Josep Font Barcelona, CELLEX-IDIBAPS Department of Autoimmune Diseases, Barcelona, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Strasbourg (UNISTRA), University of Bergen (UiB), and Michel, Geneviève
Subjects: [SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2018

22. Systemic manifestations of primary Sjogren's syndrome out of the ESSDAI classification : prevalence and clinical relevance in a large international, multi-ethnic cohort of patients

Author: Retamozo, S., Acar-Denizli, N., Rasmussen, A., Horvath, I. F., Baldini, C., Priori, R., Sandhya, P., Hernandez-Molina, G., Armagan, B., Praprotnik, S., Kvarnstrom, M., Gerli, R., Sebastian, A., Solans, R., Rischmueller, M., Pasoto, S. G., Valim, V., Nordmark, Gunnel, Kruize, A. A., Nakamura, H., Hofauer, B., Giacomelli, R., Fernandes Moca Trevisani, V., Devauchelle-Pensec, V., Atzeni, F., Gheita, T. A., Consani-Fernandez, S., Szanto, A., Sivils, K., Gattamelata, A., Danda, D., Kilic, L., Bartoloni, E., Bombardieri, S., Sanchez-Guerrero, J., Wahren-Herlenius, M., Mariette, X., Ramos-Casals, M., Brito-Zeron, P., Retamozo, S., Acar-Denizli, N., Rasmussen, A., Horvath, I. F., Baldini, C., Priori, R., Sandhya, P., Hernandez-Molina, G., Armagan, B., Praprotnik, S., Kvarnstrom, M., Gerli, R., Sebastian, A., Solans, R., Rischmueller, M., Pasoto, S. G., Valim, V., Nordmark, Gunnel, Kruize, A. A., Nakamura, H., Hofauer, B., Giacomelli, R., Fernandes Moca Trevisani, V., Devauchelle-Pensec, V., Atzeni, F., Gheita, T. A., Consani-Fernandez, S., Szanto, A., Sivils, K., Gattamelata, A., Danda, D., Kilic, L., Bartoloni, E., Bombardieri, S., Sanchez-Guerrero, J., Wahren-Herlenius, M., Mariette, X., Ramos-Casals, M., and Brito-Zeron, P.
Abstract: Objectives: To analyse the frequency and characterise the systemic presentation of primary Sjogren's syndrome (SS) out of the ESSDAI classification in a large international, multi-ethnic cohort of patients. Methods: The Big Data Sjogren Project Consortium is an international, multicentre registry based on world-wide data-sharing and cooperative merging of pre-existing clinical SS databases from leading centres in clinical research in SS from the five continents. A list of 26 organ-by-organ systemic features not currently included in the ESSDAI classification was defined according to previous studies; these features were retrospectively recorded. Results: Information about non-ESSDAI features was available in 6331 patients [5,917 female, mean age at diagnosis 52 years, mainly White (86.3%)]. A total of 1641 (26%) patients had at least one of the ESSDAI systemic features. Cardiovascular manifestations were the most frequent organ-specific group of non-ESSDAI features reported in our patients (17% of the total cohort), with Raynaud's phenomenon being reported in 15%. Patients with systemic disease due to non-ESSDAI features had a lower frequency of dry mouth (90.7% vs. 94.1%, p<0.001) and positive minor salivary gland biopsy (86.7% vs. 89%, p=0.033), a higher frequency of anti-Ro/SSA (74.7% vs. 68.7%, p<0.001), anti-La/SSB antibodies (44.5% vs. 40.4%, p=0.004), ANA (82.7% vs. 79.5%, p=0.006), low C3 levels (17.4% vs. 9.7%, p<0.001), low C4 levels (14.4% vs. 9.6%, p<0.001), and positive serum cryoglobulins (8.6% vs. 5.5%, p=0.001). Systemic activity measured by the ESSDAI, clinESSDAI and DAS was higher in patients with systemic disease out of the ESSDAI in comparison with those without these features (p<0.001 for all comparisons). Conclusions: More than a quarter of patients with primary SS may have systemic manifestations not currently included in the ESSDAI classification, with a wide variety of cardiovascular, digestive, pulmonary, neurological, ocular
Published: 2019

23. Recomendaciones para la detección, diagnóstico y seguimiento de los pacientes con enfermedad por hígado graso no alcohólico en atención primaria y hospitalaria

Author: Caballeria, L., Augustin, S., Broquetas, T., Morillas Cunill, Rosa Ma., Vergara, M., Virolés, S., Hernández, M.R., Serra, I., Goday Arnó, Albert., Vila, L., Siso-Almirall, A., Solans, R., Fernández Real, Jose Manuel, Carrión, José A, Graupera, Isabel, Ginès, Pere., Caballeria, L., Augustin, S., Broquetas, T., Morillas Cunill, Rosa Ma., Vergara, M., Virolés, S., Hernández, M.R., Serra, I., Goday Arnó, Albert., Vila, L., Siso-Almirall, A., Solans, R., Fernández Real, Jose Manuel, Carrión, José A, Graupera, Isabel, and Ginès, Pere.
Abstract: La enfermedad por hígado graso no alcohólico (EHGNA) es una de las enfermedades hepáticas crónicas más frecuentes, con una prevalencia del 20-30% en la población general y del 60-80% en poblaciones de riesgo. En un porcentaje no despreciable de pacientes la EHGNA progresa desde la esteatosis hacia a diferentes estadios de fibrosis y cirrosis. Por su alta prevalencia, la EHGNA se ha convertido en un problema de salud relevante que requiere de acciones específicas para su detección, diagnóstico, seguimiento y tratamiento. Además, dado que la EHGNA presenta un riesgo aumentado de morbimortalidad cardiovascular requiere un enfoque multidisciplinar para su tratamiento y seguimiento. Los pacientes en estadios iniciales de la enfermedad, sin fibrosis, pueden ser evaluados y recibir tratamiento en el ámbito de Atención Primaria, mientras que aquellos con enfermedad hepática avanzada se benefician de un seguimiento especializado en el ámbito hospitalario para prevenir y tratar las complicaciones hepáticas. El presente documento de consenso, elaborado por las Sociedades Catalanas de Digestología, Atención Primaria, Endocrinología, Diabetes y Medicina Interna nace de la necesidad de disenar ˜ estrategias que guíen los flujos de los pacientes entre el ámbito de Atención Primaria y Hospitalaria para poder ofrecer a los pacientes con EHGNA la mejor atención según el estadio de su enfermedad. En el documento de consenso se describen los métodos diagnósticos no invasivos más utilizados para el diagnóstico de los pacientes y se han disenado ˜ dos algoritmos para el tratamiento de los pacientes tanto en ámbito de atención primaria como de atención hospitalaria.
Published: 2019

24. Association of Functional Polymorphisms of KIR3DL1/DS1 With Behçet's Disease.

Author: Instituto de Salud Carlos III, European Commission, Junta de Andalucía, Castaño-Núñez, Á, Montes-Cano, Marco-Antonio, García-Lozano, José Raúl, Ortego-Centeno, N., García-Hernández, Francisco José, Espinosa, Gerard, Graña-Gil, Genaro, Sánchez-Bursón, J, Julià, María Rosa, Solans, R, Blanco, Ricardo, Barnosi-Marín, AC, Gómez de la Torre, Ricardo, Fanlo, P., Rodríguez-Carballeira, M., Rodríguez-Rodríguez, L., Camps, Teresa, Castañeda, Santos, Alegre-Sancho, Juan-José, Martín, J., González-Escribano, María Francisca, Instituto de Salud Carlos III, European Commission, Junta de Andalucía, Castaño-Núñez, Á, Montes-Cano, Marco-Antonio, García-Lozano, José Raúl, Ortego-Centeno, N., García-Hernández, Francisco José, Espinosa, Gerard, Graña-Gil, Genaro, Sánchez-Bursón, J, Julià, María Rosa, Solans, R, Blanco, Ricardo, Barnosi-Marín, AC, Gómez de la Torre, Ricardo, Fanlo, P., Rodríguez-Carballeira, M., Rodríguez-Rodríguez, L., Camps, Teresa, Castañeda, Santos, Alegre-Sancho, Juan-José, Martín, J., and González-Escribano, María Francisca
Abstract: Behçet's disease (BD) is an immune-mediated vasculitis related to imbalances between the innate and adaptive immune response. Infectious agents or environmental factors may trigger the disease in genetically predisposed individuals. HLA-B51 is the genetic factor stronger associated with the disease, although the bases of this association remain elusive. NK cells have also been implicated in the etiopathogenesis of BD. A family of NK receptors, Killer-cell Immunoglobulin-like Receptor (KIR), with a very complex organization, is very important in the education and control of the NK cells by the union to their ligands, most of them, HLA class I molecules. This study aimed to investigate the contribution of certain KIR functional polymorphisms to the susceptibility to BD. A total of 466 BD patients and 444 healthy individuals were genotyped in HLA class I (A, B, and C). The set of KIR genes and the functional variants of KIR3DL1/DS1 and KIR2DS4 were also determined. Frequency of KIR3DL1*004 was lower in patients than in controls (0.15 vs. 0.20, P = 0.005, Pc = 0.015; OR = 0.70; 95% CI 0.54–0.90) in both B51 positive and negative individuals. KIR3DL1*004, which encodes a misfolded protein, is included in a common telomeric haplotype with only one functional KIR gene, KIR3DL2. Both, KIR3DL1 and KIR3DL2 sense pathogen-associated molecular patterns but they have different capacities to eliminate them. The education of the NK cells depending on the HLA, the balance of KIR3DL1/KIR3DL2 licensed NK cells and the different capacities of these receptors to eliminate pathogens could be involved in the etiopathogenesis of BD.
Published: 2019

25. Pericardial tamponade preceding cutaneous involvement in systemic sclerosis

Author: Perez-Bocanegra, C., Fonolosa, V., Simeon, C. P., Candell, J., Solans, R., Gomez, A., and Vilardell, M.
Published: 1995

26. Venous thrombosis and relapses in patients with Behcet's disease. Descriptive analysis from Spanish network of Behcet's disease (REGEB cohort)

Author: Rodriguez-Carballeira, M, Solans, R, Larranaga, JR, Garcia-Hernandez, FJ, Rios-Fernandez, R, Nieto, J, Solanich, X, Martinez-Valle, F, Fonseca, E, Munoz, FJ, Fraile, G, de Escalante, B, Boldova, R, Hurtado, R, Espinosa, G, Callejas, JL, Hernandez, FG, Garrido, SL, Vidaller, A, de la Torre, RG, Herranz, MT, Todoli, J, Munoz-Rodriguez, F, Fanlo, P, Garcia-Sanchez, I, Trapiella, L, de Miguel, B, Domingo, S, Vilaplana, R, and Cusacovich, I
Subjects: relapse, immunosuppression, thrombotic recurrence, Behcet's disease, anticoagulation, thrombosis
Abstract: Objective. To describe the characteristics of patients with Behfet's disease (BD) who presented with venous thrombosis. In addition, we identified the factors associated with this venous involvement and those related with recurrent venous thrombosis. Methods. Up to January 2015, 544 BD patients from 20 Spanish hospitals had been included in the REGEB (REGistro de la Enfermedad de Behqet as Spanish nomenclature). We selected those patients who presented venous thrombosis. Descriptive analysis was performed and factors related with venous thrombosis were identified. Results. Overall, 99 (18.2%) BD patients had vascular thrombosis, 91 (16.7%) of them (16.7%) involving venous vessels and 18 (19.7%) suffered from venous thrombotic relapse. Lower limbs were the most common location of deep venous thrombosis present in up to 60% of patients. In 12 (13.2%) patients, venous thrombosis affected two vascular territories simultaneously and in 6 (6.6%) the venous and arterial involvement coincided in time. Overall, at the diagnosis of venous thrombosis, 97.6% of patients presented concomitantly other clinical symptoms attributable to BD. In logistic regression multivariate analysis factors associated to venous thrombosis were male sex (Odds ratio [OR] 4.3, 95% confidence interval [CI] 2.5-7.7), erythema nodosum (OR 2.4, 95% CI 1.4-4.1), fever (OR 2.0, 95% CI 1.1-3.8), and central nervous system (CNS) involvement (OR 2.5, 95% CI 1.3-4.8). Considering relapses, CNS involvement was an independent risk factor according logistic regression. However, Cox multivariate analysis did not confirm this finding. Conclusion. We identified factors related with venous involvement in patients included in the REGEB cohort.
Published: 2018

27. How the different systemic organ involvements are overlapped in patients with primary Sjogren syndrome: analysis using a mathematical model

Author: Retamozo, (Retamozo, S, Soledad)(, 1, 2 3 ), Kostov, (Kostov, B, 4 ), Belchin), Zeher, (Zeher, M, 5 ), Margit), Sivils, (Sivils, K, 6 ), Kathy), Mandl, (Mandl, T, 7 ), Thomas), Seror, (Seror, R, Raphaele)(, 8, Li, 9, (Li, Xm, Xiaomei)( 10, ), Baldini, (Baldini, C, Chiara)( 11, ), Mariette, (Mariette, X, Xavier)(, 8, Gottenberg, 9, (Gottenberg, Je, Jacques-Eric)( 12, ), Danda, (Danda, D, Debashish)( 13, ), Priori, (Priori, R, Roberta)( 14, ), Quartuccio, (Quartuccio, L, Luca)( 15, ), Hernandez-Molina, (Hernandez-Molina, G, Gabriela)( 16, ), Armagan, (Armagan, B, Berkan)( 17, ), Kruize, (Kruize, Aa, ( 18 ), Aike A., Kwok, (Kwok, Sk, Seung-Ki)( 19, ), Wahren-Herlenius, (Wahren-Herlenius, M, Marie)(, 20, 21, ), Praprotnik, (Praprotnik, S, Sonja)( 22, ), Sene, (Sene, D, Damien)( 23, ), Bartoloni, (Bartoloni, E, Elena)( 24, ), Rischmueller, (Rischmueller, M, Maureen)( 25, ), Solans, (Solans, R, Roser)( 26, ), Suzuki, (Suzuki, Y, Yasunori)( 27, ), Isenberg, (Isenberg, D, David)( 28, ), Valim, (Valim, V, Valeria)( 29, ), Wiland, (Wiland, P, Piotr)( 30, ), Nordmark, (Nordmark, G, Gunnel)( 31, ), Fraile, (Fraile, G, Guadalupe)( 32, ), Bootsma, (Bootsma, H, Hendrika)( 33, ), Nakamura, (Nakamura, T, Takashi)( 34, ), Giacomelli, Roberto, (Giacomelli, R, Roberto)( 35, ), Devauchelle-Pensec, (Devauchelle-Pensec, V, Valerie)( 36, ), Hofauer, (Hofauer, B, Benedikt)( 37, ), Bombardieri, (Bombardieri, M, Michele)( 38, ), Trevisani, VFM (Moca Trevisani, Virginia Fernandes)( 39, ), Hammenfors, (Hammenfors, D, Daniel)(, 40, 41, ), Pasoto, (Pasoto, Sg, ( 42 ), Sandra G., Carsons, (Carsons, Se, ( 43 ), Steven E., Gheite, (Gheite, Ta, ( 44 ), Tamer A., Atzeni, (Atzeni, F, Fabiola)( 45, ), Morel, (Morel, J, Jacques)(, 46, 47, ), Vollenveider, (Vollenveider, C, Cristina)( 48, ), Brito-Zeron, (Brito-Zeron, P, Pilar)(, 1, 49, ), Ramos-Casals, (Ramos-Casals, M, and Manuel)
Published: 2018

28. How immunological profile drives clinical phenotype of primary Sjögren's syndrome at diagnosis: analysis of 10,500 patients (Sjögren Big Data Project)

Author: Brito-Zerón, P., Acar-Denizli, N., Ng, Wf, Zeher, M., Rasmussen, A., Mandl, T., Seror, R., Li, X., Baldini, C., Gottenberg, Je, Danda, D., Quartuccio, L., Priori, R., Hernandez-Molina, G., Armagan, B., Kruize, Aa, Kwok, Sk, Marika Kvarnström, Praprotnik, S., Sène, D., Bartoloni, E., Solans, R., Rischmueller, M., Suzuki, Y., Isenberg, Da, Valim, V., Wiland, P., Nordmark, G., Fraile, G., Bootsma, H., Nakamura, T., Giacomelli, R., Devauchelle-Pensec, V., Knopf, A., Bombardieri, M., Trevisani, Vf, Hammenfors, D., Pasoto, Sg, Retamozo, S., Gheita, Ta, Atzeni, F., Morel, J., Vollenveider, C., Horvath, If, Sivils, Kl, Olsson, P., Vita, S., Sánchez-Guerrero, J., Kilic, L., Wahren-Herlenius, M., Mariette, X., Ramos-Casals, M., Sjögren Big Data Consortium, Hôpital Bicêtre, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Service de rhumatologie [Strasbourg], CHU Strasbourg-Hôpital de Hautepierre [Strasbourg], Hôpital Lariboisière, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Département de Rhumatologie[Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Hôpital Bicêtre-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11), Herrada, Anthony, and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Adult, Male, [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Complement C4, Complement C3, Middle Aged, Aged, Antibodies, Antinuclear, Autoantibodies, Biomarkers, Cryoglobulins, Female, Humans, Phenotype, Prognosis, Registries, Rheumatoid Factor, Sjogren's Syndrome, Antibodies, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Antinuclear
Abstract: International audience; OBJECTIVES:To evaluate the influence of the main immunological markers on the disease phenotype at diagnosis in a large international cohort of patients with primary Sjögren's syndrome (SjS).METHODS:The Big Data Sjögren Project Consortium is an international, multicentre registry created in 2014. As a first step, baseline clinical information from leading centres on clinical research in SjS of the 5 continents was collected. The centres shared a harmonised data architecture and conducted cooperative online efforts in order to refine collected data under the coordination of a big data statistical team. Inclusion criteria were the fulfillment of the 2002 classification criteria. Immunological tests were carried out using standard commercial assays.RESULTS:By January 2018, the participant centres had included 10,500 valid patients from 22 countries. The cohort included 9,806 (93%) women and 694 (7%) men, with a mean age at diagnosis of primary SjS of 53 years, mainly White (78%) and included from European countries (71%). The frequency of positive immunological markers at diagnosis was 79.3% for ANA, 73.2% for anti-Ro, 48.6% for RF, 45.1% for anti- La, 13.4% for low C3 levels, 14.5% for low C4 levels and 7.3% for cryoglobulins. Positive autoantibodies (ANA, Ro, La) correlated with a positive result in salivary gland biopsy, while hypocomplementaemia and especially cryoglo-bulinaemia correlated with systemic activity (mean ESSDAI score of 17.7 for cryoglobulins, 11.3 for low C3 and 9.2 for low C4, in comparison with 3.8 for negative markers). The immunological markers with a great number of statistically-significant associations (p
Published: 2018

29. Systemic Sjogren presenting without sicca syndrome: characterization of 240 patients according to the new 2017 ACR/EULAR Classification Criteria

Author: Retamozo, (Retamozo, S, Soledad)(, 1, 2 3 ), Acar-Denizli, (Acar-Denizli, N, 4 ), Nihan), Zeher, (Zeher, M, 5 ), Margit), Sivils, (Sivils, K, 6 ), Kathy), Mandl, (Mandl, T, 7 ), Thomas), Seror, (Seror, R, Raphaele)(, 8, Li, 9, (Li, Xm, Xiaomei)( 10, ), Baldini, (Baldini, C, Chiara)( 11, ), Mariette, (Mariette, X, Xavier)(, 8, Gottenberg, 9, (Gottenberg, Je, Jacques-Eric)( 12, ), Danda, (Danda, D, Debashish)( 13, ), Priori, (Priori, R, Roberta)( 14, ), Quartuccio, (Quartuccio, L, Luca)( 15, ), Hernandez-Molina, (Hernandez-Molina, G, Gabriela)( 16, ), Armagan, (Armagan, B, Berkan)( 17, ), Kruize, (Kruize, Aa, ( 18 ), Aike A., Kwok, (Kwok, Sk, Seung-Ki)( 19, ), Wahren-Herlenius, (Wahren-Herlenius, M, Marie)(, 20, 21, ), Praprotnik, (Praprotnik, S, Sonja)( 22, ), Sene, (Sene, D, Damien)( 23, ), Bartoloni, (Bartoloni, E, Elena)( 24, ), Rischmueller, (Rischmueller, M, Maureen)( 25, ), Solans, (Solans, R, Roser)( 26, ), Suzuki, (Suzuki, Y, Yasunori)( 27, ), Isenberg, (Isenberg, D, David)( 28, ), Valim, (Valim, V, Valeria)( 29, ), Wiland, (Wiland, P, Piotr)( 30, ), Nordmark, (Nordmark, G, Gunnel)( 31, ), Fraile, (Fraile, G, Guadalupe)( 32, ), Bootsma, (Bootsma, H, Hendrika)( 33, ), Nakamura, (Nakamura, T, Takashi)( 34, ), Giacomelli, Roberto, (Giacomelli, R, Roberto)( 35, ), Devauchelle-Pensec, (Devauchelle-Pensec, V, Valerie)( 36, ), Hofauer, (Hofauer, B, Benedikt)( 37, ), Bombardieri, (Bombardieri, M, Michele)( 38, ), Trevisani, VFM (Moca Trevisani, Virginia Fernandes)( 39, ), Hammenfors, (Hammenfors, D, Daniel)(, 40, 41, ), Pasoto, (Pasoto, Sg, ( 42 ), Sandra G., Carsons, (Carsons, Se, ( 43 ), Steven E., Gheita, (Gheita, Ta, ( 44 ), Tamer A., Atzeni, (Atzeni, F, Fabiola)( 45, ), Morel, (Morel, J, Jacques)(, 46, 47, ), Vollenveider, (Vollenveider, C, Cristina)( 48, ), Brito-Zeron, (Brito-Zeron, P, Pilar)(, 1, 49, ), Ramos-Casals, (Ramos-Casals, M, and Manuel)
Published: 2018

30. How ethnicity modifies systemic activity of primary Sjogren syndrome: analysis of baseline ESSDAI scores in a multi-ethnic international cohort

Author: Retamozo, (Retamozo, S, Soledad)(, 1, 2 3 ), Kostov, (Kostov, B, 4 ), Belchin), Zeher, (Zeher, M, 5 ), Margit), Sivils, (Sivils, K, 6 ), Kathy), Mandl, (Mandl, T, 7 ), Thomas), Seror, (Seror, R, Raphaele)(, 8, Li, 9, (Li, X, Xiaomei)( 10, ), Baldini, (Baldini, C, Chiara)( 11, ), Mariette, (Mariette, X, Xavier)(, 8, Gottenberg, 9, (Gottenberg, Je, Jacques-Eric)( 12, ), Danda, (Danda, D, Debashish)( 13, ), Priori, (Priori, R, Roberta)( 14, ), Quartuccio, (Quartuccio, L, Luca)( 15, ), Hernandez-Molina, (Hernandez-Molina, G, Gabriela)( 16, ), Armagan, (Armagan, B, Berkan)( 17, ), Kruize, (Kruize, Aa, ( 18 ), Aike A., Kwok, (Kwok, Sk, Seung-Ki)( 19, ), Wahren-Herlenius, (Wahren-Herlenius, M, Marie)(, 20, 21, ), Praprotnik, (Praprotnik, S, Sonja)( 22, ), Sene, (Sene, D, Damien)( 23, ), Bartoloni, (Bartoloni, E, Elena)( 24, ), Rischmueller, (Rischmueller, M, Maureen)( 25, ), Solans, (Solans, R, Roser)( 26, ), Suzuki, (Suzuki, Y, Yasunori)( 27, ), Isenberg, (Isenberg, D, David)( 28, ), Valim, (Valim, V, Valeria)( 29, ), Wiland, (Wiland, P, Piotr)( 30, ), Nordmark, (Nordmark, G, Gunnel)( 31, ), Fraile, (Fraile, G, Guadalupe)( 32, ), Bootsma, (Bootsma, H, Hendrika)( 33, ), Nakamura, (Nakamura, T, Takashi)( 34, ), Giacomelli, Roberto, (Giacomelli, R, Roberto)( 35, ), Devauchelle-Pensec, (Devauchelle-Pensec, V, Valerie)( 36, ), Hofauer, (Hofauer, B, Benedikt)( 37, ), Bombardieri, (Bombardieri, M, Michele)( 38, ), Trevisani, VFM (Moca Trevisani, Virginia Fernandes)( 39, ), Hammenfors, (Hammenfors, D, Daniel)(, 40, 41, ), Pasoto, (Pasoto, Sg, ( 42 ), Sandra G., Carsons, (Carsons, Se, ( 43 ), Steven E., Gheita, (Gheita, Ta, ( 44 ), Tamer A., Atzeni, (Atzeni, F, Fabiola)( 45, ), Morel, (Morel, J, Jacques)(, 46, 47, ), Vollenveider, (Vollenveider, C, Cristina)( 48, ), Brito-Zeron, (Brito-Zeron, P, Pilar)(, 1, 49, ), Ramos-Casals, (Ramos-Casals, M, and Manuel)
Published: 2018

31. Clinical and immunological disease patterns of primary Sjogren syndrome driven by gender and age at diagnosis

Author: Retamozo, (Retamozo, S, Soledad)(, 1, 2 3 ), Kostov, (Kostov, B, 4 ), Belchin), Zeher, (Zeher, M, 5 ), Margit), Sivils, (Sivils, K, 6 ), Kathy), Mandl, (Mandl, T, 7 ), Thomas), Seror, (Seror, R, Raphaele)(, 8, Li, 9, (Li, Xm, Xiaomei)( 10, ), Baldini, (Baldini, C, Chiara)( 11, ), Mariette, (Mariette, X, Xavier)(, 8, Gottenberg, 9, (Gottenberg, Je, Jacques-Eric)( 12, ), Danda, (Danda, D, Debashish)( 13, ), Priori, (Priori, R, Roberta)( 14, ), Quartuccio, (Quartuccio, L, Luca)( 15, ), Hernandez-Molina, (Hernandez-Molina, G, Gabriela)( 16, ), Armagan, (Armagan, B, Berkan)( 17, ), Kruize, (Kruize, Aa, ( 18 ), Aike A., Kwok, (Kwok, Sk, Seung-Ki)( 19, ), Wahren-Herlenius, (Wahren-Herlenius, M, Marie)(, 20, 21, ), Praprotnik, (Praprotnik, S, Sonja)( 22, ), Sene, (Sene, D, Damien)( 23, ), Bartoloni, (Bartoloni, E, Elena)( 24, ), Rischmueller, (Rischmueller, M, Maureen)( 25, ), Solans, (Solans, R, Roser)( 26, ), Suzuki, (Suzuki, Y, Yasunori)( 27, ), Isenberg, (Isenberg, D, David)( 28, ), Valim, (Valim, V, Valeria)( 29, ), Wiland, (Wiland, P, Piotr)( 30, ), Nordmark, (Nordmark, G, Gunnel)( 31, ), Fraile, (Fraile, G, Guadalupe)( 32, ), Bootsma, (Bootsma, H, Hendrika)( 33, ), Nakamura, (Nakamura, T, Takashi)( 34, ), Giacomelli, Roberto, (Giacomelli, R, Roberto)( 35, ), Devauchelle-Pensec, (Devauchelle-Pensec, V, Valerie)( 36, ), Hofauer, (Hofauer, B, Benedikt)( 37, ), Bombardieri, (Bombardieri, M, Michele)( 38, ), Trevisani, VFM (Moca Trevisani, Virginia Fernandes)( 39, ), Hammenfors, (Hammenfors, D, Daniel)(, 40, 41, ), Pasoto, (Pasoto, Sg, ( 42 ), Sandra G., Carsons, (Carsons, Se, ( 43 ), Steven E., Gheita, (Gheita, Ta, ( 44 ), Tamer A., Atzeni, (Atzeni, F, Fabiola)( 45, ), Morel, (Morel, J, Jacques)(, 46, 47, ), Vollenveider, (Vollenveider, C, Cristina)( 48, ), Brito-Zeron, (Brito-Zeron, P, Pilar)(, 1, 49, ), Ramos-Casals, (Ramos-Casals, M, and Manuel)
Published: 2018

32. A TNFSF13B Functional Variant Is Not Involved in Systemic Sclerosis and Giant Cell Arteritis Susceptibility

Author: Gonzalez-Serna, D, Carmona, EG, Ortego-Centeno, N, Simeon, CP, Solans, R, Hernandez-Rodriguez, J, Tolosa, C, Castaneda, S, Narvaez, J, Martinez-Valle, F, European GCA Consortium, European Scleroderma Group, Witte, T, Neumann, T, Holle, J, Beretta, L, Boiardi, L, Emmi, G, Cimmino, MA, Vaglio, A, Herrick, AL, Denton, CP, Salvarani, C, Cid, MC, Morgan, AW, Fonseca, C, Gonzalez-Gay, MA, Martin, J, Marquez, A, Márquez, Ana [0000-0001-9913-7688], Martín, Javier [0000-0002-2202-0622], Ortego-Centeno, N. [0000-0003-2325-0937], Universidad de Cantabria, Universitat de Barcelona, Márquez, Ana, Martín, Javier, and Ortego-Centeno, N.
Subjects: Male, 0301 basic medicine, Genetics and Molecular Biology (all), B Cells, Genotyping Techniques, Lydia Becker Institute, Physiology, Cooperative research, Biopsy, Autoimmunity, Biochemistry, Temporal Arteritis, Cohort Studies, White Blood Cells, Mathematical and Statistical Techniques, 0302 clinical medicine, INDEL Mutation, immune system diseases, Animal Cells, Biochemistry, Genetics and Molecular Biology (all), Agricultural and Biological Sciences (all), Immune Physiology, B-Cell Activating Factor, Medicine and Health Sciences, Gene Regulatory Networks, Molecular genetics, skin and connective tissue diseases, Aged, 80 and over, Innate Immune System, Multidisciplinary, Statistics, Middle Aged, Metaanalysis, TNFSF13B, Systemic Sclerosis, Giant Cell Arteritis, Europe, Thematic network, Physical Sciences, Cytokines, Medicine, Female, Christian ministry, Cellular Types, Research Article, Adult, Immune Cells, Science, Cèl·lules B, Giant Cell Arteritis, Immunology, Library science, Research and Analysis Methods, Genetic Predisposition, Polymorphism, Single Nucleotide, Genètica molecular, Autoimmune Diseases, 03 medical and health sciences, Political science, ResearchInstitutes_Networks_Beacons/lydia_becker_institute_of_immunology_and_inflammation, Genetics, medicine, Humans, Genetic Predisposition to Disease, Statistical Methods, Antibody-Producing Cells, Aged, 030203 arthritis & rheumatology, B cells, Scleroderma, Systemic, Blood Cells, Biology and Life Sciences, Human Genetics, Cell Biology, Molecular Development, medicine.disease, Giant cell arteritis, 030104 developmental biology, Case-Control Studies, Immune System, Genetics of Disease, Clinical Immunology, Clinical Medicine, Mathematics, Developmental Biology
Abstract: BACKGROUND: The TNFSF13B (TNF superfamily member 13b) gene encodes BAFF, a cytokine with a crucial role in the differentiation and activation of B cells. An insertion-deletion variant (GCTGT→A) of this gene, leading to increased levels of BAFF, has been recently implicated in the genetic predisposition to several autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis. Based on the elevated levels of this cytokine found in patients with giant cell arteritis (GCA) and systemic sclerosis (SSc), we aimed to assess whether this functional variant also represents a novel genetic risk factor for these two disorders. METHODS: A total of 1,728 biopsy-proven GCA patients from 4 European cohorts, 4,584 SSc patients from 3 European cohorts and 5,160 ethnically-matched healthy controls were included in the study. The single nucleotide polymorphism (SNP) rs374039502, which colocalizes with the genetic variant previously implicated in autoimmunity, was genotyped using a custom TaqMan assay. First, association analysis was conducted in each independent cohort using χ2 test in Plink (v1.9). Subsequently, different case/control sets were meta-analyzed by the inverse variance method. RESULTS: No statistically significant differences were found when allele distributions were compared between cases and controls for any of the analyzed cohorts. Similarly, combined analysis of the different sets evidenced a lack of association of the rs374039502 variant with GCA (P = 0.421; OR (95% CI) = 0.92 (0.75-1.13)) and SSc (P = 0.500; OR (95% CI) = 1.05 (0.91-1.22)). The stratified analysis considering the main clinical subphenotypes of these diseases yielded similar negative results. CONCLUSION: Our data suggest that the TNFSF13B functional variant does not contribute to the genetic network underlying GCA and SSc., Funding: This work was supported by the following grants: P12-BIO-1395 from Consejería de Innovación, Ciencia y Tecnología, Junta de Andalucía (Spain) (JM), and the Cooperative Research Thematic Network (RETICS) programme (RD16/0012/0013) (RIER) (JM), from Instituto de Salud Carlos III (ISCIII, Spanish Ministry of Economy, Industry and Competitiveness). AM is recipient of a Miguel Servet fellowship (CP17/00008) from ISCIII (Spanish Ministry of Economy, Industry and Competitiveness) (AM).
Published: 2018
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33. Relapse rate and renal prognosis in ANCA‐associated vasculitis according to long‐term ANCA patterns.

Author: Oristrell, J., Loureiro‐Amigo, J., Solans, R., Valenzuela, M. P., Monsálvez, V., Segarra, A., Amengual, M. J., Marín, A., Feijoo, C., and Tolosa, C.
Subjects: CHURG-Strauss syndrome, VASCULITIS, DISEASE relapse, PROGNOSIS, KIDNEY physiology
Abstract: Summary: Long‐term observation of patients with ANCA‐associated vasculitis (AAV) allows the identification of different longitudinal patterns of ANCA levels during follow‐up. This study aimed to characterize these patterns and to determine their prognostic significance. All ANCA determinations performed in two university hospitals during a 2‐year period were retrospectively reviewed. Patients were included in the analysis if they had high titers of anti‐myeloperoxidase (anti‐MPO) or anti‐proteinase 3 (anti‐PR3) antibodies at least once, ≥ 5 serial ANCA determinations and AAV diagnosed by biopsy or American College of Rheumatology (ACR) classification criteria. Patients' time–course ANCA patterns were classified as monophasic, remitting, recurrent or persistent. Associations between ANCA patterns and prognostic variables (relapse rate and renal outcome) were analysed by univariate and multivariate statistics. A total of 99 patients [55 with microscopic polyangiitis (MPA), 36 with granulomatosis with polyangiitis (GPA) and eight with eosinophilic granulomatosis with polyangiitis (EGPA)] were included. Median follow‐up was 9 years. Among patients diagnosed with MPA or GPA, recurrent or persistent ANCA patterns were associated with a higher risk of clinical relapse [hazard ratio (HR) = 3·7, 95% confidence interval (CI) = 1·5–9·1 and HR = 2·9, 95% CI = 1·1–8·0, respectively], independently of clinical diagnosis or ANCA specificity. In patients with anti‐MPO antibodies, the recurrent ANCA pattern was associated with worsening renal function [odds ratio (OR) = 5·7, 95% CI = 1·2–26·0]. Recurrent or persistent ANCA patterns are associated with a higher risk of clinical relapse. A recurrent ANCA pattern was associated with worsening renal function in anti‐MPO‐associated vasculitis. [ABSTRACT FROM AUTHOR]
Published: 2021
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34. SAT0457 SjÖgren big data project, the first example of data sharing in autoimmune diseases: analysis of 10475 worldwide patients

Author: Retamozo, S., primary, Acar-Denizli, N., additional, Fai Ng, W., additional, Zeher, M., additional, Rasmussen, A., additional, Mandl, T., additional, Seror, R., additional, Li, X., additional, Baldini, C., additional, Gottenberg, J.-E., additional, Danda, D., additional, Quartuccio, L., additional, Minniti, A., additional, Hernandez-Molina, G., additional, Kalyoncu, U., additional, Kruize, A.A., additional, Kwok, S.-K., additional, Wahren-Herlenius, M., additional, Praprotnik, S., additional, Sene, D., additional, Bartoloni, E., additional, Solans, R., additional, Rischmueller, M., additional, Suzuki, Y., additional, Isenberg, D., additional, Valim, V., additional, Wiland, P., additional, Nordmark, G., additional, Fraile, G., additional, Bootsma, H., additional, Nakamura, T., additional, Giacomelli, R., additional, Devauchelle-Pensec, V., additional, Hofauer, B., additional, Bombardieri, M., additional, Fernandes Moça Trevisani, V., additional, Hammenfors, D., additional, Pasoto, S.G., additional, Gheita, T.A., additional, Atzeni, F., additional, Morel, J., additional, Vollenveider, C., additional, Brito-Zerón, P., additional, and Ramos-Casals, M., additional
Published: 2018
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35. A North-South Worldwide Gradient in Systemic Activity of Primary Sjögren Syndrome : Increased Severe Disease in Patients from Southern Countries

Author: Retamozo, S., Acar-Denizli, N., Ng, W. Fai, Zeher, M., Rasmussen, A., Seror, R., Li, X., Baldini, C., Gottenberg, J. -E, Danda, D., Quartuccio, L., Priori, R., Hernandez-Molina, G., Armagan, B., Kruize, A. A., Kwok, S. -K, Wahren-Herlenius, M., Praprotnik, S., Sene, D., Bartoloni, E., Solans, R., Rischmueller, M., Mandi, T., Suzuki, Y., Isenberg, D., Valim, V., Wiland, P., Nordmark, Gunnel, Fraile, G., Bootsma, H., Nakamura, T., Giacomelli, R., Devauchelle-Pensec, V., Hofauer, B., Bombardieri, M., Fernandes Moca Trevisani, V., Hammenfors, D., Pasoto, S. G., Gheita, T. A., Atzeni, F., Morel, J., Vollenveider, C., Brito-Zeron, P., Ramos-Casals, M., Retamozo, S., Acar-Denizli, N., Ng, W. Fai, Zeher, M., Rasmussen, A., Seror, R., Li, X., Baldini, C., Gottenberg, J. -E, Danda, D., Quartuccio, L., Priori, R., Hernandez-Molina, G., Armagan, B., Kruize, A. A., Kwok, S. -K, Wahren-Herlenius, M., Praprotnik, S., Sene, D., Bartoloni, E., Solans, R., Rischmueller, M., Mandi, T., Suzuki, Y., Isenberg, D., Valim, V., Wiland, P., Nordmark, Gunnel, Fraile, G., Bootsma, H., Nakamura, T., Giacomelli, R., Devauchelle-Pensec, V., Hofauer, B., Bombardieri, M., Fernandes Moca Trevisani, V., Hammenfors, D., Pasoto, S. G., Gheita, T. A., Atzeni, F., Morel, J., Vollenveider, C., Brito-Zeron, P., and Ramos-Casals, M.
Published: 2018
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36. Influence of epidemiology and ethnicity on systemic expression of primary Sjögren syndrome in 9974 patients

Author: Retamozo, S., Acar-Denizli, N., Ng, W. Fai, Zeher, M., Rasmussen, A., Seror, R., Li, X., Baldini, C., Gottenberg, J. -E, Danda, D., Quartuccio, L., Priori, R., Hernandez-Molina, G., Armagan, B., Kruize, A. A., Kwok, S. -K, Wahren-Herlenius, M., Praprotnik, S., Sene, D., Bartoloni, E., Solans, R., Rischmueller, M., Mandl, T., Suzuki, Y., Isenberg, D., Valim, V., Wiland, P., Nordmark, Gunnel, Fraile, G., Bootsma, H., Nakamura, T., Giacomelli, R., Devauchelle-Pensee, V., Hofauer, B., Bombardieri, M., Fernandes Moca Trevisani, V., Hammenfors, D., Pasoto, S. G., Gheita, T. A., Atzeni, F., Morel, J., Vollenveider, C., Brito-Zeron, P., Ramos-Casals, M., Retamozo, S., Acar-Denizli, N., Ng, W. Fai, Zeher, M., Rasmussen, A., Seror, R., Li, X., Baldini, C., Gottenberg, J. -E, Danda, D., Quartuccio, L., Priori, R., Hernandez-Molina, G., Armagan, B., Kruize, A. A., Kwok, S. -K, Wahren-Herlenius, M., Praprotnik, S., Sene, D., Bartoloni, E., Solans, R., Rischmueller, M., Mandl, T., Suzuki, Y., Isenberg, D., Valim, V., Wiland, P., Nordmark, Gunnel, Fraile, G., Bootsma, H., Nakamura, T., Giacomelli, R., Devauchelle-Pensee, V., Hofauer, B., Bombardieri, M., Fernandes Moca Trevisani, V., Hammenfors, D., Pasoto, S. G., Gheita, T. A., Atzeni, F., Morel, J., Vollenveider, C., Brito-Zeron, P., and Ramos-Casals, M.
Published: 2018
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37. A Genome-wide Association Study Identifies Risk Alleles in Plasminogen and P4HA2 Associated with Giant Cell Arteritis

Author: Carmona, DF, Vaglio, A, Mackie, SL, Hernández-Rodríguez, J, Monach, PA, Castaneda, S, Solans, R, Morado, IC, Narvaez, J, Ramentol-Sintas, M, Pease, CT, Dasgupta, B, Watts, R, Khalidi, N, Langford, CA, Ytterberg, S, Boiardi, L, Beretta, L, Govoni, M, Emmi, G, Bonatti, F, Cimmino, MA, Witte, T, Neumann, T, Holle, A, Schonau, V, Sailler, L, Papo, T, Haroche, J, Mahr, A, Mouthon, L, Molberg, O, Diamantopoulos, AP, Voskuyl, A, Brouwer, E, Daikeler, T, Berger, CT, Molloy, ES, O'Neill, L, Blockmans, D, Lie, BA, Mclaren, P, Vyse, TJ, Wijmenga, C, Allanore, Y, Koeleman, BPC, Spanish CGA Group, UKGCA Consortium, Vasculitis Clinical Research Consortium, Barrett, JH, Cid, MC, Salvarini, C, Merkel, PA, Morgan, AW, Gonzalez-Gay, MA, and Martin, J
Subjects: Genetics, Journal Article, Genetics(clinical)
Abstract: Giant cell arteritis (GCA) is the most common form of vasculitis in individuals older than 50 years in Western countries. To shed light onto the genetic background influencing susceptibility for GCA, we performed a genome-wide association screening in a well-powered study cohort. After imputation, 1,844,133 genetic variants were analyzed in 2,134 case subjects and 9,125 unaffected individuals from ten independent populations of European ancestry. Our data confirmed HLA class II as the strongest associated region (independent signals: rs9268905, p = 1.94 × 10−54, per-allele OR = 1.79; and rs9275592, p = 1.14 × 10−40, OR = 2.08). Additionally, PLG and P4HA2 were identified as GCA risk genes at the genome-wide level of significance (rs4252134, p = 1.23 × 10−10, OR = 1.28; and rs128738, p = 4.60 × 10−9, OR = 1.32, respectively). Interestingly, we observed that the association peaks overlapped with different regulatory elements related to cell types and tissues involved in the pathophysiology of GCA. PLG and P4HA2 are involved in vascular remodelling and angiogenesis, suggesting a high relevance of these processes for the pathogenic mechanisms underlying this type of vasculitis.
Published: 2017

38. Baseline ESSDAI/DAS scores in 8061 patients with primary sjÖgren syndrome: characterization of systemic disease

Author: Brito-Zerόn, P, Acar-Denizli, N, Zeher, M, Rasmussen, A, Li, X, Baldini, C, Gottenberg, J-E, Danda, D, Quartuccio, L, Hernandez-Molina, G, Kruize, Aa, Park, S-H, Kvarnström, M, Praprotnik, S, Sene, D, Alunno, A, Solans, R, Mandl, T, Suzuki, Y, Rischmueller, M, Nordmark, G, Fraile, G, Wiland, P, Bootsma, H, Nakamura, T, Valim, V, Giacomelli, R, Seror, R, Devauchelle-Pensec, V, Hofauer, B, Bombardieri, M, Trevisani, V, Hammenfors, D, Minniti, A, Pasoto, Sg, Morel, J, Retamozo, S, Gheita, Ta, Atzeni, F, Vollenveider, C, Mariette, X, and Ramos-Casals, M
Published: 2017

39. THU0320 Different patterns of vascular involvement in PET/CT according to cranial symptoms in biopsy proven giant cell arteritis, a preliminary study

Author: Torres, J Mestre, primary, Navales, I, additional, Martínez, F, additional, Loureiro, J, additional, Bujan, S, additional, Pérez, C, additional, Simό, M, additional, and Solans, R, additional
Published: 2017
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40. A Large-Scale Genetic Analysis Reveals a Strong Contribution of the HLA Class II Region to Giant Cell Arteritis Susceptibility

Author: David Carmona, F, Mackie, SL, Martin, J-E, Taylor, JC, Vaglio, A, Eyre, S, Bossini-Castillo, L, Castaneda, S, Cid, MC, Hernandez-Rodriguez, J, Prieto-Gonzalez, S, Solans, R, Ramentol-Sintas, M, Francisca Gonzalez-Escribano, M, Ortiz-Fernandez, L, Morado, IC, Narvaez, J, Miranda-Filloy, JA, Beretta, L, Lunardi, C, Cimmino, MA, Gianfreda, D, Santilli, D, Ramirez, GA, Soriano, A, Muratore, F, Pazzola, G, Addimanda, O, Wijmenga, C, Witte, T, Schirmer, JH, Moosig, F, Schoenau, V, Franke, A, Palm, O, Molberg, O, Diamantopoulos, AP, Carette, S, Cuthbertson, D, Forbess, LJ, Hoffman, GS, Khalidi, NA, Koening, CL, Langford, CA, McAlear, CA, Moreland, L, Monach, PA, Pagnoux, C, Seo, P, Spiera, R, Sreih, AG, Warrington, KJ, Ytterberg, SR, Gregersen, PK, Pease, CT, Gough, A, Green, M, Hordon, L, Jarrett, S, Watts, R, Levy, S, Patel, Y, Kamath, S, Dasgupta, B, Worthington, J, Koeleman, BPC, de Bakker, PIW, Barrett, JH, Salvarani, C, Merkel, PA, Gonzalez-Gay, MA, Morgan, AW, Martin, J, Carmona, F. David, Mackie, Sarah L., Martín, Jose-Ezequiel, Taylor, John C., Vaglio, Augusto, Eyre, Stephen, Bossini-Castillo, Lara, Castañeda, Santo, Cid, Maria C., Hernández-Rodríguez, José, Prieto-González, Sergio, Solans, Roser, Ramentol-Sintas, Marc, González-Escribano, M. Francisca, Ortiz-Fernández, Lourde, Morado, Inmaculada C., Narváez, Javier, Miranda-Filloy, José A., Beretta, Lorenzo, Lunardi, Claudio, Cimmino, Marco A., Gianfreda, Davide, Santilli, Daniele, Ramirez, Giuseppe A., Soriano, Alessandra, Muratore, Francesco, Pazzola, Giulia, Addimanda, Olga, Wijmenga, Cisca, Witte, Torsten, Schirmer, Jan H., Moosig, Frank, Schönau, Verena, Franke, Andre, Palm, Oyvind, Molberg, Oyvind, Diamantopoulos, Andreas P., Carette, Simon, Cuthbertson, David, Forbess, Lindsy J., Hoffman, Gary S., Khalidi, Nader A., Koening, Curry L., Langford, Carol A., Mcalear, Carol A., Moreland, Larry, Monach, Paul A., Pagnoux, Christian, Seo, Philip, Spiera, Robert, Sreih, Antoine G., Warrington, Kenneth J., Ytterberg, Steven R., Gregersen, Peter K., Pease, Colin T., Gough, Andrew, Green, Michael, Hordon, Lesley, Jarrett, Stephen, Watts, Richard, Levy, Sarah, Patel, Yusuf, Kamath, Sanjeet, Dasgupta, Bhaskar, Worthington, Jane, Koeleman, Bobby P.C., De Bakker, Paul I.W., Barrett, Jennifer H., Salvarani, Carlo, Merkel, Peter A., González-Gay, Miguel A., Morgan, Ann W., and Martín, Javier
Subjects: Multifactorial Inheritance, Genotype, European Continental Ancestry Group, Genes, MHC Class II, Giant Cell Arteritis, Genetic Association Studie, Article, White People, MHC Class II, Cohort Studies, Genetic, Genes, Genetic Association Studies, Humans, Multivariate Analysis, Odds Ratio, Genetics, Genetics(clinical), Cohort Studie, Multivariate Analysi, Giant Cell Arteriti, Genetics (clinical), Human
Abstract: We conducted a large-scale genetic analysis on giant cell arteritis (GCA), a polygenic immune-mediated vasculitis. A case-control cohort, comprising 1,651 case subjects with GCA and 15,306 unrelated control subjects from six different countries of European ancestry, was genotyped by the Immunochip array. We also imputed HLA data with a previously validated imputation method to perform a more comprehensive analysis of this genomic region. The strongest association signals were observed in the HLA region, with rs477515 representing the highest peak (p = 4.05 × 10(-40), OR = 1.73). A multivariate model including class II amino acids of HLA-DRβ1 and HLA-DQα1 and one class I amino acid of HLA-B explained most of the HLA association with GCA, consistent with previously reported associations of classical HLA alleles like HLA-DRB1(∗)04. An omnibus test on polymorphic amino acid positions highlighted DRβ1 13 (p = 4.08 × 10(-43)) and HLA-DQα1 47 (p = 4.02 × 10(-46)), 56, and 76 (both p = 1.84 × 10(-45)) as relevant positions for disease susceptibility. Outside the HLA region, the most significant loci included PTPN22 (rs2476601, p = 1.73 × 10(-6), OR = 1.38), LRRC32 (rs10160518, p = 4.39 × 10(-6), OR = 1.20), and REL (rs115674477, p = 1.10 × 10(-5), OR = 1.63). Our study provides evidence of a strong contribution of HLA class I and II molecules to susceptibility to GCA. In the non-HLA region, we confirmed a key role for the functional PTPN22 rs2476601 variant and proposed other putative risk loci for GCA involved in Th1, Th17, and Treg cell function.
Published: 2015

41. Analysis Of 9302 Patients From The Big Data International Primary Sjogren Syndrome Cohort : Clinical Presentation At Diagnosis Of European Vs Non-European Patients

Author: Brito-Zeron, P., Acar-Denizli, N., Zeher, M., Rasmussen, A., Seror, R., Mandl, T., Li, X., Baldini, C., Gottenberg, J. -E, Danda, D., Priori, R., Quartuccio, L., Hernandez-Molina, G., Kruize, A., Park, S. -H, Kvarnstrom, M., Praprotnik, S., Sene, D., Bartoloni, E., Solans, R., Suzuki, Y., Isenberg, D., Rischmueller, M., Nordmark, Gunnel, Fraile, G., Sebastian, A., Vissink, A., Nakamura, T., Valim, V., Giacomelli, R., Devauchelle-Pensec, V., Hofauer, B., Bombardieri, M., Trevisani, V., Hammenfors, D., Carsons, S. E., Pasoto, S. G., Morel, J., Retamozo, S., Gheita, T. A., Atzeni, F., Vollenveider, C., Mariette, X., Ramos-Casals, M., Brito-Zeron, P., Acar-Denizli, N., Zeher, M., Rasmussen, A., Seror, R., Mandl, T., Li, X., Baldini, C., Gottenberg, J. -E, Danda, D., Priori, R., Quartuccio, L., Hernandez-Molina, G., Kruize, A., Park, S. -H, Kvarnstrom, M., Praprotnik, S., Sene, D., Bartoloni, E., Solans, R., Suzuki, Y., Isenberg, D., Rischmueller, M., Nordmark, Gunnel, Fraile, G., Sebastian, A., Vissink, A., Nakamura, T., Valim, V., Giacomelli, R., Devauchelle-Pensec, V., Hofauer, B., Bombardieri, M., Trevisani, V., Hammenfors, D., Carsons, S. E., Pasoto, S. G., Morel, J., Retamozo, S., Gheita, T. A., Atzeni, F., Vollenveider, C., Mariette, X., and Ramos-Casals, M.
Published: 2017
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42. Baseline Essdai/ Das Scores In 8061 Patients With Primary Sjögren Syndrome : Characterization Of Systemic Disease

Author: Brito-Zeron, P., Acar-Denizli, N., Zeher, M., Rasmussen, A., Li, X., Baldini, C., Gottenberg, J-E, Danda, D., Quartuccio, L., Hernandez-Molina, G., Kruize, A. A., Park, S-H, Kvarnstrom, M., Praprotnik, S., Sene, D., Alunno, A., Solans, R., Mandl, T., Suzuki, Y., Rischmueller, M., Nordmark, Gunnel, Fraile, G., Wiland, P., Bootsma, H., Nakamura, T., Valim, V., Giacomelli, R., Seror, R., Devauchelle-Pensec, V., Hofauer, B., Bombardieri, M., Trevisani, V., Hammenfors, D., Minniti, A., Pasoto, S. G., Morel, J., Retamozo, S., Gheita, T. A., Atzeni, F., Vollenveider, C., Mariette, X., Ramos-Casals, M., Brito-Zeron, P., Acar-Denizli, N., Zeher, M., Rasmussen, A., Li, X., Baldini, C., Gottenberg, J-E, Danda, D., Quartuccio, L., Hernandez-Molina, G., Kruize, A. A., Park, S-H, Kvarnstrom, M., Praprotnik, S., Sene, D., Alunno, A., Solans, R., Mandl, T., Suzuki, Y., Rischmueller, M., Nordmark, Gunnel, Fraile, G., Wiland, P., Bootsma, H., Nakamura, T., Valim, V., Giacomelli, R., Seror, R., Devauchelle-Pensec, V., Hofauer, B., Bombardieri, M., Trevisani, V., Hammenfors, D., Minniti, A., Pasoto, S. G., Morel, J., Retamozo, S., Gheita, T. A., Atzeni, F., Vollenveider, C., Mariette, X., and Ramos-Casals, M.
Published: 2017
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43. Predicting Survival In 6240 Patients With Primary Sjögren' Syndrome (Big Data Sjögren Project)

Author: Brito-Zeron, P., Acar-Denizli, N., Zeher, M., Rasmussen, A., Li, X., Baldini, C., Gottenberg, J-E, Danda, D., Quartuccio, L., Hernandez-Molina, G., Kruize, A. A., Park, S-H, Kvarnstrom, M., Praprotnik, S., Sene, D., Bartoloni, E., Solans, R., Mandl, T., Suzuki, Y., Rischmueller, M., Nordmark, Gunnel, Fraile, G., Sebastian, A., Bootsma, H., Nakamura, T., Valim, V., Giacomelli, R., Seror, R., Devauchelle-Pensec, V., Hofauer, B., Bombaidieri, M., Trevisani, V., Hammenfors, D., Priori, R., Pasoto, S. G., Morel, J., Retamozo, S., Gheita, T. A., Atzeni, F., Vollenveider, C., Mariette, X., Ramos-Casals, M., Brito-Zeron, P., Acar-Denizli, N., Zeher, M., Rasmussen, A., Li, X., Baldini, C., Gottenberg, J-E, Danda, D., Quartuccio, L., Hernandez-Molina, G., Kruize, A. A., Park, S-H, Kvarnstrom, M., Praprotnik, S., Sene, D., Bartoloni, E., Solans, R., Mandl, T., Suzuki, Y., Rischmueller, M., Nordmark, Gunnel, Fraile, G., Sebastian, A., Bootsma, H., Nakamura, T., Valim, V., Giacomelli, R., Seror, R., Devauchelle-Pensec, V., Hofauer, B., Bombaidieri, M., Trevisani, V., Hammenfors, D., Priori, R., Pasoto, S. G., Morel, J., Retamozo, S., Gheita, T. A., Atzeni, F., Vollenveider, C., Mariette, X., and Ramos-Casals, M.
Published: 2017
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44. Ethnic Differences Strongly Influence The Phenotypic Expression of Primary Sjögren : Study of 7887 Patients from 20 Countries on 5 Continents (EULAR-SS Task Force Big Data Sjögren Project)

Author: Brito-Zeron, P., Acar-Denizli, N., Zeher, M., Rasmussen, A., Seror, R., Mandl, T., Li, X., Baldini, C., Gottenberg, J. -E, Danda, D., Quartuccio, L., Priori, R., Hernandez-Molina, G., Kruize, A., Valim, V., Kvarnstrom, M., Sene, D., Gerli, R., Praprotnik, S., Isenberg, D., Solans, R., Rischmueller, M., Park, S. -H, Nordmark, Gunnel, Suzuki, Y., Giacomelli, R., Saraux, A., Bombardieri, M., Hofauer, B., Bootsma, H., Hammenfors, D., Fraile, G., Carsons, S., Gheita, T., Morel, J., Vollenveider, C., Atzeni, F., Retamozo, S., Horvath, I. -F, Sivils, K., Theander, E., Sandhya, P., De Vita, S., Sanchez-Guerrero, J., van der Heijden, E., Moca-Trevisano, V., Wahren-Herlenius, M., Mariette, X., Ramos-Casals, M., Brito-Zeron, P., Acar-Denizli, N., Zeher, M., Rasmussen, A., Seror, R., Mandl, T., Li, X., Baldini, C., Gottenberg, J. -E, Danda, D., Quartuccio, L., Priori, R., Hernandez-Molina, G., Kruize, A., Valim, V., Kvarnstrom, M., Sene, D., Gerli, R., Praprotnik, S., Isenberg, D., Solans, R., Rischmueller, M., Park, S. -H, Nordmark, Gunnel, Suzuki, Y., Giacomelli, R., Saraux, A., Bombardieri, M., Hofauer, B., Bootsma, H., Hammenfors, D., Fraile, G., Carsons, S., Gheita, T., Morel, J., Vollenveider, C., Atzeni, F., Retamozo, S., Horvath, I. -F, Sivils, K., Theander, E., Sandhya, P., De Vita, S., Sanchez-Guerrero, J., van der Heijden, E., Moca-Trevisano, V., Wahren-Herlenius, M., Mariette, X., and Ramos-Casals, M.
Published: 2016
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45. Worldwide Heterogeneous Diagnostic Approach To Primary Sjögren Syndrome in 8315 Patients (EULAR-SS Task Force Big Data Sjögren Project)

Author: Brito-Zeron, P., Acar-Denizli, N., Zeher, M., Rasmussen, A., Seror, R., Mandl, T., Li, X., Baldini, C., Gottenberg, J. -E, Danda, D., Quartuccio, L., Priori, R., Hernandez-Molina, G., Kruize, A., Valim, V., Kvarnstrom, M., Sene, D., Bartoloni, E., Praprotnik, S., Isenberg, D., Solans, R., Rischmueller, M., Kwok, S. -K, Nordmark, Gunnel, Suzuki, Y., Giacomelli, R., Devauchelle-Pensec, V., Bombardieri, M., Hofauer, B., Bootsma, H., Hammenfors, D., Fraile, G., Carsons, S., Gheita, T., Morel, J., Vollenveider, C., Atzeni, F., Retamozo, S., Horvath, I. -F, Sivils, K., Theander, E., Sandhya, P., De Vita, S., Sanchez-Guerrero, J., van der Heijden, E., Moca-Trevisano, V., Wahren-Herlenius, M., Mariette, X., Ramos-Casals, M., Brito-Zeron, P., Acar-Denizli, N., Zeher, M., Rasmussen, A., Seror, R., Mandl, T., Li, X., Baldini, C., Gottenberg, J. -E, Danda, D., Quartuccio, L., Priori, R., Hernandez-Molina, G., Kruize, A., Valim, V., Kvarnstrom, M., Sene, D., Bartoloni, E., Praprotnik, S., Isenberg, D., Solans, R., Rischmueller, M., Kwok, S. -K, Nordmark, Gunnel, Suzuki, Y., Giacomelli, R., Devauchelle-Pensec, V., Bombardieri, M., Hofauer, B., Bootsma, H., Hammenfors, D., Fraile, G., Carsons, S., Gheita, T., Morel, J., Vollenveider, C., Atzeni, F., Retamozo, S., Horvath, I. -F, Sivils, K., Theander, E., Sandhya, P., De Vita, S., Sanchez-Guerrero, J., van der Heijden, E., Moca-Trevisano, V., Wahren-Herlenius, M., Mariette, X., and Ramos-Casals, M.
Published: 2016
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46. SAT0287 Ethnic Differences Strongly Influence The Phenotypic Expression of Primary Sjögren: Study of 7887 Patients from 20 Countries on 5 Continents (EULAR-SS Task Force Big Data Sjögren Project)

Author: Brito-Zerόn, P., primary, Acar-Denizli, N., additional, Zeher, M., additional, Rasmussen, A., additional, Seror, R., additional, Mandl, T., additional, Li, X., additional, Baldini, C., additional, Gottenberg, J.-E., additional, Danda, D., additional, Quartuccio, L., additional, Priori, R., additional, Hernández-Molina, G., additional, Kruize, A., additional, Valim, V., additional, Kvarnstrom, M., additional, Sene, D., additional, Gerli, R., additional, Praprotnik, S., additional, Isenberg, D., additional, Solans, R., additional, Rischmueller, M., additional, Park, S.-H., additional, Nordmark, G., additional, Suzuki, Y., additional, Giacomelli, R., additional, Saraux, A., additional, Bombardieri, M., additional, Hofauer, B., additional, Bootsma, H., additional, Hammenfors, D., additional, Fraile, G., additional, Carsons, S., additional, Gheita, T., additional, Morel, J., additional, Vollenveider, C., additional, Atzeni, F., additional, Retamozo, S., additional, Horvath, I.-F., additional, Sivils, K., additional, Theander, E., additional, Sandhya, P., additional, De Vita, S., additional, Sanchez-Guerrero, J., additional, van der Heijden, E., additional, Moça-Trevisano, V., additional, Wahren-Herlenius, M., additional, Mariette, X., additional, and Ramos-Casals, M., additional
Published: 2016
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47. Identification of the PTPN22 functional variant R620W as susceptibility genetic factor for giant cell arteritis

Author: Serrano, A., Marquez, A., Mackie, S.L., Carmona, F.D., Solans, R., Miranda-Filloy, J.A., Hernandez-Rodriguez, J., Cid, M.C., Castaneda, S., Morado, I.C., Narvaez, J., Blanco, R., Sopena, B., Garcia-Villanueva, M.J., Monfort, J., Ortego-Centeno, N., Unzurrunzaga, A., Mari-Alfonso, B., Sanchez-Martin, J., Miguel, E. de, Magro, C., Raya, E., Braun, N., Latus, J., Molberg, O., Lie, B.A., Moosig, F., Witte, T., Morgan, A.W., Gonzalez-Gay, M.A., Martin, J., UK GCA Consortium, and Spanish GCA Consortium
Subjects: Gene Polymorphism, Polymyalgia Rheumatica, Giant Cell Arteritis
Published: 2013

48. Analysis of two autoimmunity genes, IRAK1 and MECP2, in giant cell arteritis

Author: Marquez, A., Solans, R., Hernandez-Rodriguez, J., Cid, M. C., Castaneda, S., Ramentol, M., Morado, I. C., Rodriguez-Rodriguez, L., Narvaez, J., Gomez-Vaquero, C., Miranda-Filloy, J. A., Martinez-Taboada, V. M., Rios, R., Sopena, B., Monfort, J., Garcia-Villanueva, M. J., Martinez-Zapico, A., Mari-Alfonso, B., Sanchez-Martin, J., Unzurrunzaga, A., Raya, E., Miguel, E., Hidalgo-Conde, A., Blanco, R., Gonzalez-Gay, M. A., Martin, J., and Spanish, G. C. A. Consortium
Subjects: Methyl-CpG-Binding Protein 2, Biopsy, Giant Cell Arteritis, Autoimmunity, Arteries, Polymorphism, Single Nucleotide, White People, Interleukin-1 Receptor-Associated Kinases, Gene Frequency, Spain, Humans, Female, Genetic Predisposition to Disease, Aged
Abstract: The Xq28 region, containing IRAK and MECP2, represent a common susceptibility locus for a high number of autoimmune diseases. Our aim in the present study was to evaluate the influence of the IRAK1 and MECP2 autoimmunity-associated genetic variants in the giant cell arteritis (GCA) susceptibility and its clinical subphenotypes.We analysed a total of 627 female biopsy-proven GCA patients and 1,520 female healthy controls of Spanish Caucasian origin. Two polymorphisms, rs1059702 and rs17345, located at IRAK1 and MECP2, respectively, were genotyped using TaqMan® allelic discrimination assays.No association with any of the analysed polymorphisms was evident when genotype and allele frequencies were compared between GCA patients and controls (rs1059702: allelic p-value=0.699, OR=0.96, CI 95% 0.80-1.17; rs17435: allelic p-value=0.994, OR=1.00, CI 95% 0.84-1.19). Likewise, the subphenotype analysis yield similar negative results.We have assessed for the first time the possible role of IRAK1 and MECP2 autoimmune disease-associated polymorphisms in GCA. Our data suggest that IRAK1 rs1059702 and MECP2 rs17435 genetic variants do not play a significant role in GCA susceptibility or severity.
Published: 2013

49. The Functional PTPN22 Variant R620W Is Strongly Associated With Giant Cell Artetitis Predisposition

Author: Carmona, F.D., Mackie, S.L., Serrano, A., Marquez, A., Solans, R., Miranda-Filloy, J.A., Hernandez-Rodriguez, J., Cid, M.C., Castaneda, S., Morado, I.C., Narvaez, J., Blanco, R., Sopena, B., Garcia-Villanueva, M.J., Monfort, J., Ortego-Centeno, N., Unzurrunzaga, A., Mari-Alfonso, B., Sanchez-Martin, J., Miguel, E. de, Magro, C., Raya, E., Braun, N., Latus, J., Molberg, O., Lie, B.A., Moosig, F., Witte, T., Morgan, A.W., Gonzalez-Gay, M.A., and Martin, J.
Published: 2013

50. OP0089 Big Data Sjögren Project (Eular-SS Task Force International Network): Characterization at Diagnosis of 5027 Patients with Primary Sjögren Syndrome

Author: Brito Zeron, P., primary, Kostov, B.A., additional, Zeher, M., additional, Theander, E., additional, Gottenberg, J.-E., additional, Baldini, C., additional, Quartuccio, L., additional, Priori, R., additional, Kvarnstrom, M., additional, Kruize, A., additional, Hernández Molina, G., additional, Praprotnik, S., additional, Isenberg, D., additional, Bartoloni, E., additional, Rasmussen, A., additional, Solans, R., additional, Valim, V., additional, Giacomelli, R., additional, Carsons, S., additional, Hammenfors, D., additional, Vollenweider, C., additional, Atzeni, F., additional, Mandl, T., additional, De Vita, S., additional, Wahren-Herlenius, M., additional, Sanchez-Guerrero, J., additional, Gerli, R., additional, Sivils, K., additional, Mowa, S., additional, Brun, J.G., additional, Mariette, X., additional, and Ramos-Casals, M., additional
Published: 2015
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