On a daily basis in inclusive secondary classrooms, teachers struggle to address the academic and social needs of autistic adolescents. Many general education teachers feel unprepared to work directly with students with autism, and the problem is even more complicated in high-poverty, high minority communities which may have greater numbers of students demonstrating characteristics of such disorders but no formal diagnosis or have a delayed diagnosis (Chaidez, Hansen, & Herz-Picciotto, 2012). For instance, one important research study emphasized this very point by surmising that although autistic spectrum disorders (ASD) are identified across all racial, ethnic and socioeconomic groups, diagnosing children with autism is a complicated process and further exacerbated for culturally and linguistically diverse children especially in high poverty regions (Mandell, Wiggins, Carpenter, Daniels, DiGuiseppi, Durkin, Giarelli, Morrier, Nicholas, Pinto-Martin, Shattuck, Thomas, Yeargin-Allsopp, & Kirby, 2009). In these communities, it is important that general education classroom teachers be able to recognize indicators of ASD, especially of high-functioning autistic children and utilize effective classroom-level strategies and interventions if they are to serve all students. These strategies and interventions, grounded in research, reflect sound principles of good teaching in general, and will benefit not only students with ASD but all learners in inclusive classrooms. This article resulted from the collaboration between an occupational therapist and teacher educator working with children and pre-service teachers in a predominately Hispanic community. By highlighting the therapeutic practice of working with autistic children in this region, along with best-practice recommendations from teacher education literature, this article provides a description of three practical research-based teaching lessons and a series of functional behavior assessment model interventions to target the sensory issues that may underlie challenging classroom behaviors of autistic children for the general education teacher. [ABSTRACT FROM AUTHOR]