1. Mendelian resistance to human norovirus infections
- Author
-
Lennart Svensson, Jacques Le Pendu, Elin Kindberg, and Nathalie Ruvoën-Clouet
- Subjects
viruses ,Le, Lewis antigen ,medicine.disease_cause ,RT-PCR, reverse transcriptase polymerase chain reaction ,RHDV, Rabbit Hemorrhagic Disease Virus ,Secretor ,fluids and secretions ,Immunology and Allergy ,Caliciviridae Infections ,Infectivity ,NTPase, nucleoside triphosphate ,Glc, glucose ,GG, genogroup ,Gastroenteritis ,HIV, human immunodeficiency virus ,Capsid ,CCR5, chemokine receptor 5 ,SMV, Snow Mountain virus ,symbols ,Histo-blood group antigen ,VLP, virus-like particles ,FUT2, α1,2fucosyltransferase ,Fuc, fucose ,FUT2 ,Immunology ,IgG, immunoglobulin G ,Biology ,Article ,Virus ,Microbiology ,symbols.namesake ,ORF, open reading frame ,Antigen ,Immunity ,medicine ,Animals ,Humans ,Genetic Predisposition to Disease ,HBGA, histo-blood group antigen ,Gene ,Norovirus ,Pol, polymerase ,Virology ,VP, virus protein ,Gal, galactose ,Pro, proteinase ,NV, Norwalk virus ,RNA, ribonucleic acid ,Mendelian inheritance ,NAc, N-acetyl - Abstract
Noroviruses have emerged as a major cause of acute gastroenteritis in humans of all ages. Despite high infectivity of the virus and lack of long-term immunity, volunteer and authentic studies has suggested the existence of inherited protective factors. Recent studies have shown that histo-blood group antigens (HBGAs) and in particular secretor status controlled by the α1,2fucosyltransferase FUT2 gene determine susceptibility to norovirus infections, with nonsecretors (FUT2-/-), representing 20% of Europeans, being highly resistant to symptomatic infections with major strains of norovirus. Moreover, the capsid protein from distinct strains shows different HBGA specificities, suggesting a host-pathogen co-evolution driven by carbohydrate-protein interactions. © 2006.
- Published
- 2006
- Full Text
- View/download PDF