1. Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus.
- Author
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Smetanina, Olga F., Yurchenko, Anton N., Girich (Ivanets), Elena V., Trinh, Phan Thi Hoai, Antonov, Alexander S., Dyshlovoy, Sergey A., von Amsberg, Gunhild, Kim, Natalya Y., Chingizova, Ekaterina A., Pislyagin, Evgeny A., Menchinskaya, Ekaterina S., Yurchenko, Ekaterina A., Van, Tran Thi Thanh, Afiyatullov, Shamil S., and Sakai, Ryuichi
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MARINE fungi , *ASPERGILLUS , *PARKINSON'S disease - Abstract
Seven known echinulin-related indolediketopiperazine alkaloids (1–7) were isolated from the Vietnamese sediment-derived fungus Aspergillus niveoglaucus. Using chiral HPLC, the enantiomers of cryptoechinuline B (1) were isolated as individual compounds for the first time. (+)-Cryptoechinuline B (1a) exhibited neuroprotective activity in 6-OHDA-, paraquat-, and rotenone-induced in vitro models of Parkinson's disease. (−)-Cryptoechinuline B (1b) and neoechinulin C (5) protected the neuronal cells against paraquat-induced damage in a Parkinson's disease model. Neoechinulin B (4) exhibited cytoprotective activity in a rotenone-induced model, and neoechinulin (7) showed activity in the 6-OHDA-induced model. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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