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Objectives: Stroke is an important etiological factor in seizures and epilepsies of advanced age. In this study, it was planned to determine the location of lesions and EEG findings in 106 patients with post-stroke seizures, who were followed in the Neurology Department of Uludağ University, Faculty of Medicine, retrospectively. Methods: Archive files of 4221 patients diagnosed with epilepsy admitted to the Neurology Department of Uludağ University, Faculty of Medicine were screened, and one hundred and six patients, with stroke as the etiology of epilepsy, were included into the study. Information on the demographical features of patients and past histories, stroke type, age at stroke, etiology of stroke, and stroke localization according to neuro-imaging, seizure on set date after stroke, seizure type, and anti-epileptic treatment were all recorded. Neuro-imaging findings were identified according to the arteries involved such as ACA (anterior cerebral artery), MCA (middle cerebral artery), PCA (posterior cerebral artery) and others. Moreover, EEG findings were classified as normal, slow wave activity and epileptiform activity. Data was compared statistically. Results: Sixty-three of 106 patients were male (59%) and 43 were female (41%). Fifty-eight patients (54.7%) had early-onset seizures (first 15 days after stroke), whereas 48 patients (45.3%) had late-onset seizures. Arterial stroke regions were categorized as MCA for 52 patients (49.1 %), PCA for 28 patients (26.4%), ACA for 14 patients (13.2%) and others for 12 patients (11.3%). EEG findings were recorded as normal for 13 patients (12.3%). EEG features were corresponding to location of lesions on neuro-imaging in 54 patients (51%), not corresponding in 39 patients (36.7%). Concordance of EEG findings was especially significant in strokes of the MCA region (p<0.05). Conclusion: EEG findings after infarctions were usually recorded as slow wave activity corresponding to the location of the lesion, and sometimes epileptiform activities can accompany. In cases with stroke, EEG has a limited place; however, if evaluated with clinical findings and neuro-imaging data, EEG is important as a supporting diagnostic test. [ABSTRACT FROM AUTHOR]

Objective: This study aimed to conduct a unified analysis comparing the clinical characteristics, disease progression, and treatment responses of pediatric-onset multiple sclerosis (POMS), adult-onset multiple sclerosis (AOMS), and late-onset multiple sclerosis (LOMS) patients., Methods: Utilizing a retrospective cohort design, we analyzed the records of 269 patients from MS clinics and categorized them into the POMS (<18 years), AOMS (≥18 and <50 years), and LOMS (≥50 years) groups based on age at diagnosis. Data collection focused on demographics, clinical manifestations, disability scores, MRI findings, and treatment outcomes., Results: Our findings indicate that while there was a consistent female majority across all groups, distinct smoking habits and differences in disease onset and progression were observed. Disease onset showed substantial differences, with 38.5 % of LOMS patients having a progressive onset. Disability scores increased from the POMS to the LOMS, with a baseline mean EDSS score of 1.81, and the LOMS group had the highest current EDSS score of 3.33. The ARR was greater in the LOMS group. Brainstem and spinal cord lesions were more common in patients with POMS and LOMS, but the difference was not statistically significant. Among those tested, 89.6 % showed OCB positivity. There was a notable shift toward second-line therapies, especially among LOMS patients, with 49.1 % achieving disease control with their initial DMT. Disease control was achieved by 59.7 % of the POMS patients, 47 % of the AOMS patients, and 38.5 % of the LOMS patients. Progression independent of relapse activity (PIRA) was observed in 19.7 % of patients, with higher second-line treatment requirements and higher EDSS scores in the PIRA group., Conclusion: Significant differences in clinical profiles and treatment responses among POMS, AOMS, and LOMS patients underscore the necessity for age-specific management strategies for MS, emphasizing the unique challenges faced by LOMS patients., Competing Interests: Declaration of competing interest The authors have no relevant financial or non-financial interests to disclose., (Copyright © 2024 Elsevier B.V. All rights reserved.)