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1. Prolonged or recurrent acute seizures after pediatric arterial ischemic stroke are associated with increasing epilepsy risk.

Author

Fox, Christine K, Mackay, Mark T, Dowling, Michael M, Pergami, Paola, Titomanlio, Luigi, Deveber, Gabrielle, and SIPS Investigators

Subjects
SIPS Investigators, Humans, Brain Ischemia, Epilepsy, Recurrence, Risk Factors, Follow-Up Studies, Age Factors, Online Systems, Adolescent, Child, Child, Preschool, Infant, Infant, Newborn, Female, Male, Stroke, Neurodegenerative, Clinical Research, Brain Disorders, Pediatric, Neurosciences, 7.3 Management and decision making, Pediatrics, Medical and Health Sciences
Abstract

AimTo determine epilepsy risk factors after pediatric stroke.MethodA cohort of children with arterial ischemic stroke (birth-18y) was enrolled at 21 centers and followed for 1 year. Acute seizures (≤7d after stroke) and active epilepsy (at least one unprovoked remote seizure plus maintenance anticonvulsant at 1y) were identified. Predictors were determined using logistic regression.ResultsAmong 114 patients (28 neonates and 86 children) enrolled, 26 neonates (93%) and 32 children (37%) had an acute seizure. Acute seizures lasted longer than 5 minutes in 23 patients (40%) and were frequently recurrent: 33 (57%) had 2 to 10 seizures and 11 (19%) had more than 10. Among 109 patients with 1-year follow-up, 11 (10%) had active epilepsy. For each year younger, active epilepsy was 20% more likely (odds ratio [OR] 0.8, 95% confidence interval [CI] 0.6-0.99, p=0.041). Prolonged or recurrent acute seizures also increased epilepsy risk. Each additional 10 minutes of the longest acute seizure increased epilepsy risk fivefold (OR 4.7, 95% CI 1.7-13). Patients with more than 10 acute seizures had a 30-fold increased epilepsy risk (OR 30, 95% CI 2.9-305).InterpretationPediatric stroke survivors, especially younger children, have a high risk of epilepsy 1 year after stroke. Prolonged or recurrent acute seizures increase epilepsy risk in a dose-dependent manner.

Published
2017

2. Seizures and Outcome One Year After Neonatal and Childhood Cerebral Sinovenous Thrombosis

Author

Mineyko, Aleksandra, Kirton, Adam, Billinghurst, Lori, Tatishvili, Nana Nino, Wintermark, Max, deVeber, Gabrielle, Fox, Christine, and SIPS Investigators

Subjects
Male, Adolescent, Outcome Assessment, SIPS Investigators, Outcomes, Neurodegenerative, Sinus Thrombosis, Paediatrics and Reproductive Medicine, Seizures, Clinical Research, Humans, 2.1 Biological and endogenous factors, Aetiology, Child, Preschool, Ischemic Stroke, Pediatric, Epilepsy, Neurology & Neurosurgery, Pediatric stroke, Neurosciences, Infant, Hematology, Perinatal Period - Conditions Originating in Perinatal Period, Newborn, Intracranial, Brain Disorders, Health Care, Stroke, Neurological, Cerebral sinovenous thrombosis, Anticonvulsants, Female, Follow-Up Studies
Abstract

BackgroundPediatric cerebral sinovenous thrombosis is a treatable cause of brain injury, acute symptomatic seizures, and remote epilepsy. Our objective was to prospectively study epilepsy and outcomes in neonates and children one year after cerebral sinovenous thrombosis diagnosis.MethodsPatients with cerebral sinovenous thrombosis were enrolled prospectively from 21 international sites through the Seizures in Pediatric Stroke Study. Clinical data, including acute symptomatic seizures and cerebral sinovenous thrombosis risk factors, were collected at diagnosis. A neuroradiologist who was unaware of the diagnosis reviewed acute imaging. At one year, outcomes including seizure recurrence, epilepsy diagnosis, antiepileptic drug use, and modified Engel score were collected. Outcomes were assessed using the modified Rankin score and the King's Outcome Scale for Childhood Head Injury.ResultsTwenty-four participants with cerebral sinovenous thrombosis were enrolled (67% male, 21% neonates). Headache was the most common presenting symptom in non-neonates (47%, nine of 19). Nine (37.5%) presented with acute symptomatic seizures. Six (25%; 95% confidence interval,10% to 47%) developed epilepsy by one-year follow-up. No clinical predictors associated with epilepsy were identified. King's Outcome Scale for Childhood Head Injury and modified Rankin scores at one year were favorable in 71%. Half of the patients who developed epilepsy (three of six) did not have infarcts, hemorrhage, or seizures identified during the acute hospitalization.ConclusionOur study provides a prospective estimate that epilepsy occurs in approximately one-quarter of patients by one year after diagnosis of cerebral sinovenous thrombosis. Later epilepsy can develop in the absence of acute seizures or parenchymal injury associated with the acute presentation.

Published
2020

4. Prolonged or recurrent acute seizures after pediatric arterial ischemic stroke are associated with increasing epilepsy risk.

Author

Fox, CK, Mackay, MT, Dowling, MM, Pergami, P, Titomanlio, L, Deveber, G, SIPS Investigators, Fox, CK, Mackay, MT, Dowling, MM, Pergami, P, Titomanlio, L, Deveber, G, and SIPS Investigators

Abstract

AIM: To determine epilepsy risk factors after pediatric stroke. METHOD: A cohort of children with arterial ischemic stroke (birth-18y) was enrolled at 21 centers and followed for 1 year. Acute seizures (≤7d after stroke) and active epilepsy (at least one unprovoked remote seizure plus maintenance anticonvulsant at 1y) were identified. Predictors were determined using logistic regression. RESULTS: Among 114 patients (28 neonates and 86 children) enrolled, 26 neonates (93%) and 32 children (37%) had an acute seizure. Acute seizures lasted longer than 5 minutes in 23 patients (40%) and were frequently recurrent: 33 (57%) had 2 to 10 seizures and 11 (19%) had more than 10. Among 109 patients with 1-year follow-up, 11 (10%) had active epilepsy. For each year younger, active epilepsy was 20% more likely (odds ratio [OR] 0.8, 95% confidence interval [CI] 0.6-0.99, p=0.041). Prolonged or recurrent acute seizures also increased epilepsy risk. Each additional 10 minutes of the longest acute seizure increased epilepsy risk fivefold (OR 4.7, 95% CI 1.7-13). Patients with more than 10 acute seizures had a 30-fold increased epilepsy risk (OR 30, 95% CI 2.9-305). INTERPRETATION: Pediatric stroke survivors, especially younger children, have a high risk of epilepsy 1 year after stroke. Prolonged or recurrent acute seizures increase epilepsy risk in a dose-dependent manner.

Published
2017

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