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Vaccination is an effective, simple, safeway of providing protection against harmful diseases, before contact with public. Vaccination develops immunity to particular infections and makes our immune system stronger to produce antibodies. Most of the vaccines are administered by parenteral route, but few are given by mouth or sprayed into the nose.We should believe fair and equitable access to safe and effective vaccines is only weapon to end the pandemic, so WHO is hugely working with an effort to encourage the partners to develop and manufacture safe and effective vaccines, a challenging game tool, but in the future we must continue wearing masks, sanitizing our hands, with good ventilation indoors, physical distancing and avoid crowding. Being vaccinated does not mean that we can throw caution to the wind and put ourselves and others at risk, particularly because research is still ongoing on how much vaccines gives protection against disease, infection and transmission.Vaccines may not guarantee protection from infection, they are still doing an amazing job of substantially reducing hospitalization and death related to Covid 19.

Background: Diuretics increase urine flow and sodium excretion are used to maintain the volume and composition of body fluids in a variety of clinical situations Objectives: To evaluate the diuretic activity of alcoholic (AERMI) extract of roots of Mangifera indica in albino rats. Methods: 5 groups of Albino rats were used to evaluate the diuretic activity by using metabolic cages. The group I serves as normal control received vehicle, the group II received Furosemide (10 mg/Kg, p.o) ; other groups III, IV, V were treated with low, medium, and high doses of AERMI and immediately after extract treatment all the rats were hydrated with saline (15 ml/kg) and placed in metabolic cages. Total volume of urine collected was measured at the end of 5 h. Concentration of Sodium, Potassium, Chloride in the urine were estimated. Results: Compared to control group the AERMI at different dose levels (100,200 and 400 mg/kg) has significantly increased the urine volume and also enhanced the elimination of Sodium, Potassium and Chloride. Conclusion: Single dose of AERMI as 100, 200 and 400 mg/Kg and Frusemide have increased the urine output along with an increase in concentration of Sodium, Potassium, and Chloride.

Background: Adverse drug reactions (ADR) are a major cause of morbidity and mortality around the world. This issue can be addressed with a good pharmacovigilance (PV) programme. One of the barriers to good PV is underreporting of ADR. To accomplish this, health practitioners must have sufficient ADR knowledge, attitude, and practise (KAP). Objective: To assess KAP about PV among post graduate (PG) students. Methods: A self-administered questionnaire with 22 items addressing knowledge, attitude, and practise about PV was delivered to PG students in MIMS College's clinical departments. Direct supervision was provided during the completion of the surveys. The results of the completed questionnaires were evaluated using a Microsoft Excel spreadsheet. Results: Evaluation showed an average of 52.3% correct and 47.7% incorrect knowledge about ADR`s and PV.50% students are not sure regarding occurrence of ADR.90% students are not been trained upon reporting of ADR`s. Our research discovered that while PG students had a more positive attitude regarding PV, they have insufficient knowledge and awareness about the subject. We also discovered that the students lacked practise. Conclusions: PV knowledge and awareness among PG students can be imparted by regular educational intervention, resulting in better practise among PG students.

Background: Adverse drug reactions (ADR) are global problem causing morbidity and mortality. Good pharmacovigilance (PV) programme can address this problem. Under reporting of ADR is one of the obstacles for good PV. In order to achieve this, health professionals need to have enough Knowledge, attitude and practice (KAP) of ADR`s. The present study was conducted to assess KAP about PV among post graduate (PG) students.Methods: A self administered questionnaire validated by Lynn M consisting of 22 questions covering knowledge, attitude & practice about PV was distributed among PG students of clinical departments of MIMS College. Answering of the questionnaires was supervised directly. Filled questionnaires were analyzed by using Microsoft Excel spread sheet.Results: Evaluation showed an average of 52.3% correct and 47.7% incorrect knowledge about ADR`s and PV.50% students are not sure regarding occurrence of ADR.90% students are not been trained upon reporting of ADR`s. Our study found out that PG students have better attitude towards PV, but have improper knowledge & less awareness about PV. We also found lack of practice among the students.Conclusions: Imparting knowledge and awareness of PV among the PG students by means of continuous educational intervention can create better practice among PG students.