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The French "OMIN registry" was established in 2015 to collect nationwide standardised data concerning biological, clinical, environmental and social characteristics of sudden unexpected death in infancy (SUDI) and unexpected death in children aged 1–2 years. A biobank has existed since July 2020 to store biological samples for each case. This article aimed to detail (1) a brief history and the objectives of the registry; (2) a description of the methodology used; (3) the first results of the registry, i.e. the main characteristics of the cases included so far; (4) the process for accessing the data for research projects; and (5) issues regarding weakness and improvement and perspectives offered by the registry. On 31 May 2024, 1975 cases were included in the OMIN registry; on 31 December 2022, 4606 biological samples from 176 cases were collected. For each deceased child, different types of data are registered on an electronic case report form: socio-demographic data, personal and familial medical background, environment and feeding data, clinical data, and biological and imaging results. A strict and continuous quality control process is used to ensure the reliability of the data, in parallel with specific actions to improve the exhaustiveness of the registry. The OMIN registry database is one of the largest and the most complete databases on SUDI, especially in Europe, and the first in the world to associate a standardised biological sample collection with it. Perspectives of research provided by our registry are numerous and could be supported by national and international scientific collaborations. Conclusion: This article details the objectives and methods of the French registry of SUDI. It provides initial results relating to the population included in the register and the procedure for accessing the data. What is Known: • In Western Europe, France is one of the countries with the highest SUDI rate, making it the first cause of death of infants between 28 and 364 days. • The development of epidemiological tools on a national and international scale is essential to advance research into the determinants and risk factors of unexpected death in children under 2 years of age. What is New: • The OMIN registry was created in France in 2015 to collect nationwide standardised social, environmental, clinical, and paraclinical data for cases of unexpected death in children aged 0 to 2 years. • To date, the OMIN registry has included 680 data from almost 2000 children unexpectedly deceased, completed by a biocollection since 2020. • Data from the OMIN registry, unique in its field, are freely available for scientific research teams, after acceptation by the scientific committee of the registry. [ABSTRACT FROM AUTHOR]

The purpose of this study is to gain insights into potential genetic factors contributing to the infant's vulnerability to Sudden Unexpected Infant Death (SUID). Whole Genome Sequencing (WGS) was performed on 144 infants that succumbed to SUID, and 573 healthy adults. Variants were filtered by gnomAD allele frequencies and predictions of functional consequences. Variants of interest were identified in 88 genes, in 64.6% of our cohort. Seventy‐three of these have been previously associated with SIDS/SUID/SUDP. Forty‐three can be characterized as cardiac genes and are related to cardiomyopathies, arrhythmias, and other conditions. Variants in 22 genes were associated with neurologic functions. Variants were also found in 13 genes reported to be pathogenic for various systemic disorders and in two genes associated with immunological function. Variants in eight genes are implicated in the response to hypoxia and the regulation of reactive oxygen species (ROS) and have not been previously described in SIDS/SUID/SUDP. Seventy‐two infants met the triple risk hypothesis criteria. Our study confirms and further expands the list of genetic variants associated with SUID. The abundance of genes associated with heart disease and the discovery of variants associated with the redox metabolism have important mechanistic implications for the pathophysiology of SUID. [ABSTRACT FROM AUTHOR]

The diaphragm is the primary muscle of respiration. Here, we disclose a fascinating patient's perspective that led, by clinical reasoning alone, to a novel mechanism of spontaneous respiratory arrests termed diaphragm cramp-contracture (DCC). Although the 7-year-old boy survived its paroxysmal nocturnal "bearhug pain apnea" episodes, essentially by breathing out to breathe in, DCC could cause sudden unexpected deaths in children, especially infants. Diaphragm fatigue is central to the DCC hypothesis in SIDS. Most, if not all, SIDS risk factors contribute to it, such as male sex, young infancy, rebreathing, nicotine, overheating and viral infections. A workload surge by a roll to prone position or REM-sleep inactivation of airway dilator or respiratory accessory muscles can trigger pathological diaphragm excitation (e.g., spasms, flutter, cramp). Electromyography studies in preterm infants already show that diaphragm fatigue and sudden temporary failure by transient spasms induce apneas, hypopneas and forced expirations, all leading to hypoxemic episodes. By extension, prolonged spasm as a diaphragm cramp would induce sustained apnea with severe hypoxemia and cardiac arrest if not quickly aborted. This would cause a sudden, rapid, silent death consistent with SIDS. Moreover, a unique airway obstruction could develop where the hypercontracted diaphragm resists terminal inspiratory efforts by the accessory muscles. It would disappear postmortem. SIDS autopsy evidence consistent with DCC includes disrupted myofibers and contraction band necrosis as well as signs of agonal breathing from obstruction. Screening for diaphragm injury from hypoxemia, hyperthermia, viral myositis and excitation include serum CK-MM and skeletal troponin-I. Active excitation could be visualized on ultrasound or fluoroscopy and monitored by respiratory inductive plethysmography or electromyography. [ABSTRACT FROM AUTHOR]

Glial fibrillary acidic protein (GFAP) immunohistochemistry was investigated in the developing human brain using two measures; the number of GFAP‐positive cells (density, GFAP+/mm2), and a reactivity score (R‐score), which we recently introduced to indicate astrogliosis, with scores ≥120 indicative of pathological processes. The primary aim was to report on GFAP expression and cell soma size in 26 microscopically defined regions of the amygdala, basal ganglia, cerebellum, hippocampus and medulla, and to determine whether they are affected by postconceptional age (PCA) from 40 to 83 weeks. The secondary aim was to determine if GFAP expression differs according to the classification of sudden infant death syndrome (SIDS) as opposed to infant deaths of known causes, or for the presence of major SIDS risk factors of male sex, cigarette smoke exposure, upper respiratory tract infection (URTI), bed‐sharing and prone sleeping. The cerebellar molecular layer was void of GFAP+ cells, while the internal granular layer (IGL) had the highest density, with >60% of infants having an R‐Score >120. GFAP expression decreased with increasing PCA in the entorhinal and temporal cortex, subiculum and regions of the cerebellum and medulla. GFAP cell soma size corresponded with astrogliosis score and no effect of PCA was evident. Various region‐dependent GFAP expressional differences were seen according to SIDS classification and the risk factors studied. The findings indicate that the density of GFAP decreases in specific regions of the brain within the first year of postnatal development, and that reactive astrocytes are common, particularly within the early postnatal months. [ABSTRACT FROM AUTHOR]

Sudden infant death syndrome (SIDS) is the most common cause of death for infants between 1 month and 1 year of age in the United States. The objective was to examine recent trends in SIDS in the United States, over time and by sex and race. A population-based cross-sectional study was conducted on 80 710 348 live births using data from the Center for Disease Control and Prevention's (CDC) "Birth Data" and "Mortality Multiple Cause" files from 2000 to 2019. Logistic regression examined the effects of sex and race on the risk of SIDS and examined temporal changes in risk across sex and race over the study period. Incidence of SIDS decreased from 6.3 to 3.4/10 000 births from 2000 to 2019, with an overall incidence of 4.9/10 000 births (95% confidence interval [CI] = 4.4-5.3). Male infants were at the greatest risk of SIDS as were black and American Indian infants. Although SIDS incidence decreased by sex and race over time, the decline was smaller among Hispanic and American Indian infants. [ABSTRACT FROM AUTHOR]

A key to achieving the 17 Sustainable Development Goals is the sustainable provisioning of clean water and sanitation services. The sustainable management of water resources strengthens resilience, protects livelihoods, fosters economic growth, and contributes to poverty reduction. This paper reviews the challenges faced by Caribbean Small Island Developing States (SIDS) with a focus on water resource management. While the Caribbean region is seemingly blessed with water resources, with more than 90% of Caribbean residents having access to improved water, it faces challenges due to inefficient management and diverse geographical realities, creating spatial disparities. Furthermore, economic and physical scarcity coexist with some islands lacking proper infrastructure and others nearing the exhaustion of natural freshwater reserves. Climate change intensifies these issues through variable precipitation patterns and extreme weather events. Additionally, the region's dependence on tourism and susceptibility to environmental pressures necessitates a focus on targets related to SDGs 1 and 8. To address increasing water stress within the region, it is becoming increasingly urgent to identify root causes and develop targeted solutions that consider socioeconomic and environmental factors. The promotion of Integrated Water Resource Management is a key strategy for encouraging increased investment in climate-resilient infrastructure and fostering sustainable financing practices. Article Highlights: Caribbean islands face water scarcity due to climate change, population growth, and outdated infrastructure. Effective water management strategies are crucial for ensuring access to clean water and supporting local economies. Collaborative efforts and investments in resilient infrastructure can enhance water security across the region. [ABSTRACT FROM AUTHOR]

Background: Sudden unexpected infant death (SUID) continues to be a leading cause of death in infants in the United States (US), with significant disparities by race and socio-economic status. Infant safe sleep behaviors are associated with decreasing SUID risk, but challenges remain for families to practice these routinely. The objective of this program was to implement and evaluate a novel approach for an infant safe sleep pilot program built upon partnerships between hospitals and community-based organizations (CBOs) serving pregnant and parenting families in at-risk communities. Methods: Community Partnership Approaches to Safe Sleep (CPASS) was a prospectively implemented infant safe sleep program. CPASS included children's hospitals partnered with CBOs across five US cities: Portland, OR, Little Rock AR, Chicago, IL, Birmingham, AL, and Rochester, NY. The program consisted of (1) monthly learning community calls; (2) distribution of Safe Sleep Survival Kits; and (3) surveys of sites and families regarding program outcomes. Survey measures included (1) site participation in CPASS activities; (2) recipients' use of Safe Sleep Kits; and (3) recipients' safe sleep knowledge and behaviors. Results: CPASS learning community activities were consistently attended by at least two representatives (1 hospital-based, 1 CBO-based) from each site. Across the five sites, 1002 safe kits were distributed over 9 months, the majority (> 85%) to families with infants ≤ 1 month old. Among participating families, 45% reported no safe sleep location before receipt of the kit. Family adherence to nighttime safe sleep recommendations included: (1) no bedsharing (M 6.0, SD 1.8, range 0–7); (2) sleep on back (M 6.3, SD 1.7, range 0–7); and (3) sleep in a crib with no blankets/toys (M 6.0, SD 2.0, range 0–7). Site interviews described how participation in CPASS influenced safe sleep conversations and incorporated local data into counseling. Hospital-CBO relationships were strengthened with program participation. Conclusions: The CPASS pilot program provides a new, innovative model built on hospital-community partnerships for infant safe sleep promotion in SUID-impacted communities. CPASS reached families before their infant's peak age risk for SUID and empowered families with knowledge and resources to practice infant safe sleep. Important lessons learned included improved ways to center and communicate with families. [ABSTRACT FROM AUTHOR]

Tourism resembles an indispensable source for financing national development and securing local livelihoods in Small Island Developing States (SIDS) with their sun-sea-sand tourism. Related carbon dioxide (CO2) emissions counteract sectoral development as climate impacts have begun to severely reduce the attractiveness of destinations. This is valid especially for disaster-prone SIDS where slow and rapid onsetting phenomena and severe, frequent weather events are already experienced, increasingly putting tourist assets, infrastructure, local livelihoods and unique biodiversity under pressure. Against this background, this review synthesizes the recent climate change and tourism literature relating to main SIDS regions, highlighting what is at risk. The authors provide latest evidence of the role tourism plays for these islands and elaborate the peculiar climate risks, impacts and consequences for tourism development. The current state of adaptation is explored and research priorities in SIDS regions are highlighted. Whereas SIDS show high mitigation ambition, the significance of CO2 emissions along the value chain and especially related to the transport to SIDS destinations remains a problem that developed nations must address in their national emission reduction plans. Further research at the interface of climate change and tourism is needed, contributing to the decarbonisation of tourism and successful adaptation in SIDS. [ABSTRACT FROM AUTHOR]

Abstract A key to achieving the 17 Sustainable Development Goals is the sustainable provisioning of clean water and sanitation services. The sustainable management of water resources strengthens resilience, protects livelihoods, fosters economic growth, and contributes to poverty reduction. This paper reviews the challenges faced by Caribbean Small Island Developing States (SIDS) with a focus on water resource management. While the Caribbean region is seemingly blessed with water resources, with more than 90% of Caribbean residents having access to improved water, it faces challenges due to inefficient management and diverse geographical realities, creating spatial disparities. Furthermore, economic and physical scarcity coexist with some islands lacking proper infrastructure and others nearing the exhaustion of natural freshwater reserves. Climate change intensifies these issues through variable precipitation patterns and extreme weather events. Additionally, the region’s dependence on tourism and susceptibility to environmental pressures necessitates a focus on targets related to SDGs 1 and 8. To address increasing water stress within the region, it is becoming increasingly urgent to identify root causes and develop targeted solutions that consider socioeconomic and environmental factors. The promotion of Integrated Water Resource Management is a key strategy for encouraging increased investment in climate-resilient infrastructure and fostering sustainable financing practices.

Abstract Background Sudden unexpected infant death (SUID) continues to be a leading cause of death in infants in the United States (US), with significant disparities by race and socio-economic status. Infant safe sleep behaviors are associated with decreasing SUID risk, but challenges remain for families to practice these routinely. The objective of this program was to implement and evaluate a novel approach for an infant safe sleep pilot program built upon partnerships between hospitals and community-based organizations (CBOs) serving pregnant and parenting families in at-risk communities. Methods Community Partnership Approaches to Safe Sleep (CPASS) was a prospectively implemented infant safe sleep program. CPASS included children’s hospitals partnered with CBOs across five US cities: Portland, OR, Little Rock AR, Chicago, IL, Birmingham, AL, and Rochester, NY. The program consisted of (1) monthly learning community calls; (2) distribution of Safe Sleep Survival Kits; and (3) surveys of sites and families regarding program outcomes. Survey measures included (1) site participation in CPASS activities; (2) recipients’ use of Safe Sleep Kits; and (3) recipients’ safe sleep knowledge and behaviors. Results CPASS learning community activities were consistently attended by at least two representatives (1 hospital-based, 1 CBO-based) from each site. Across the five sites, 1002 safe kits were distributed over 9 months, the majority (> 85%) to families with infants ≤ 1 month old. Among participating families, 45% reported no safe sleep location before receipt of the kit. Family adherence to nighttime safe sleep recommendations included: (1) no bedsharing (M 6.0, SD 1.8, range 0–7); (2) sleep on back (M 6.3, SD 1.7, range 0–7); and (3) sleep in a crib with no blankets/toys (M 6.0, SD 2.0, range 0–7). Site interviews described how participation in CPASS influenced safe sleep conversations and incorporated local data into counseling. Hospital-CBO relationships were strengthened with program participation. Conclusions The CPASS pilot program provides a new, innovative model built on hospital-community partnerships for infant safe sleep promotion in SUID-impacted communities. CPASS reached families before their infant’s peak age risk for SUID and empowered families with knowledge and resources to practice infant safe sleep. Important lessons learned included improved ways to center and communicate with families.

This study examines the relationship between Zanzibar’s debt service and economic growth (GDP per capita) from 1987 to 2022. Employing a Vector Error Correction Mechanism (VECM) with time series data, we analyze the long-run impact of debt service on growth. While our results show a positive correlation, it’s not statistically significant. This suggests that effective debt management, fostering investor confidence and stability, can potentially stimulate growth. The study emphasizes the importance of balanced debt strategies and informed policymaking for Zanzibar’s sustainable development. It highlights the complexities of debt-growth dynamics, underlining the need for fiscal discipline and prudent debt management for long-term prosperity. This research offers valuable insights for policymakers navigating debt and economic policy in island economies.

The seascapes of Small Island Developing States are at risk from anthropogenic pollution. To implement effective seascape management, there is a need to better understand the threats to the seascape, subsequent impacts and associated stakeholder perceptions. This study used a systematic literature review, online survey and follow-up interviews to identify the main threats and impacts to the seascape and analyze associated perceptions of stakeholders, using Mauritius as a case study. The key threats were found to be oil spills, anthropogenic marine debris, coastal development, tourism, poor environmental management, and inadequate enforcement of legislation. Associated perception data showed a high awareness of increasing pollution, some awareness of the impacts and a general consensus that the seascape is poorly managed. Stricter law enforcement and increased education were suggested by stakeholders to improve seascape management. It is hoped this data will inform future studies and subsequently improve the effectiveness of seascape management. [ABSTRACT FROM AUTHOR]

Introduction: The Eastern Caribbean island of Dominica has experienced diverse negative effects from the North Atlantic hurricane season, including deadly storms like Hurricane Maria in 2017. Vulnerability is increased by geographic location, small island developing state (SIDS) status, and ecosystem characteristics. A variety of negative health effects including stress and anxiety are caused by powerful storms. The perspectives of middle-aged (the "sandwich generation") survivors in this post-storm milieu are understudied. Methods: This phenomenological qualitative study describes the perceptions of middle-aged (35-55 years) Dominicans, purposively recruited with gatekeeper assistance from communities stratified according to four natural hazard vulnerability categories designated by the Climate Resilience Execution Agency for Dominica (CREAD), regarding their lived experiences in the context of severe storms. Data was collected between June and August 2022, using primarily Zoom-based semi-structured, individual interviews (12 of 13), guided by the principles of saturation and maximum variation. Verbatim interview transcripts were thematically analyzed with constant comparison using an ATLAS.ti-supported hybrid deductive-inductive coding frame. Reflexivity and contact summary sheets were used to minimize bias. Results: Ten women and three men from diverse CREAD vulnerability and sociodemographic backgrounds were recruited. Data condensation yielded three organizing themes: (i) "The diverse health effects of severe storms", (ii) "Response to and recovery from severe storms", and (iii) "Preparedness and precaution for severe storms". These themes encapsulated the health impacts of severe storms on Dominicans and elucidated the role of facilitating and barricading resilience factors. Discussion: Severe storms produced direct and indirect mental, social, and physical health impacts on middle-aged Dominicans, including anxiety and burnout. Participants used faith-based, tangible community-based support, and emotional mechanisms to cope with and demonstrate resilience. Better risk communication and early warning systems would improve population readiness. Persistent dispirited attitudes toward storm preparedness among some participants suggest the need for targeted methods to enhance community involvement in disaster planning, including traditional approaches like "coup-de-main" (self-help). [ABSTRACT FROM AUTHOR]

Without the availability of a vaccine (at the time of writing) to control the spread of the COVID-19 virus, countries must rely largely on lockdown measures to limit population movement and community spread. The case of COVID-19 in small island territories is particularly important given their vulnerabilities to external shocks, limited capacity to prepare for and respond to a health crisis, and a population susceptible to non-communicable diseases. This article utilise novel crowdsourced cell phone data gathered by Facebook Data for Good and difference-in-differences estimation as well as event studies to examine the effectiveness of shelter-in-place orders (SIPOs) on population movement patterns across Trinidad and Tobago. We find that most SIPOs result in reductions in population movement patterns across the country, the most effective being the closure of all public places and non-essential businesses. Also, the relaxation of these measures does not readily result in increasing population movement patterns, indicating relative embeddedness in population movement. Our results further suggest that voluntary compliance, adaptive behaviour among citizens, government transparency and public information can also be important motivations for reduced population movement during the pandemic. [ABSTRACT FROM AUTHOR]

A less than one-month-old infant with symptoms of rhinitis died unexpectedly in his sleep. He was not born prematurely and had no known underlying disease. Cerebrospinal fluid, nasopharyngeal and lung samples, and rectal swab were found to be positive for subgroup A rhinovirus, while the blood was negative. This case highlights the important finding that the rhinovirus, a common pathogen associated with upper respiratory tract infections, can sometimes, as the only pathogen, lead to complications such as a cerebrospinal infection and be involved in the sudden infant death syndrome (SIDS). Vigilance is necessary in case of viral infections in the infant's environment, and measures of hygiene and protection must be encouraged in order to reduce the risk of the SIDS. [ABSTRACT FROM AUTHOR]

Ethical consumerism is one of this century's retail success stories and has continued to grow despite the global pandemic and economic contraction. Consumers worldwide are increasingly putting their money where their values are in purchases of food and drink, clothing, housing, and financial and other services. Understanding these consumers is key to competing successfully in markets for ethically sourced products and presents opportunities for reducing poverty in developing countries where food and agricultural production is the dominant economic activity, such as small island developing states (SIDS) in the Pacific. While ethical consumerism is an expanding research field, findings rarely are analysed in detail for market development. Rarer still is segmentation in terms of product attributes aimed explicitly at poverty reduction in slow-growth, emerging economies like those of the Pacific. Here we report a latent class cluster analysis of survey responses by ethically conscious Australian consumers (n = 637) associated with Oxfam, the development charity. Four distinct consumer segments were identified with implications for Pacific producers. Product origin and 'the story behind the product' were particularly important to these consumers. The findings provide practical insights to agricultural stakeholders in the Pacific and those similarly situated around the globe that are in need of new economic opportunities. [ABSTRACT FROM AUTHOR]

This is a Letter to the Editor in response to Kariks J. Diaphragmatic muscle fibre necrosis in SIDS. Forensic Sci Int. 1989 Dec;43(3):281–91. doi: 10.1016/0379-0738(89)90156-4. PMID: 2613142.

IntroductionThe Eastern Caribbean island of Dominica has experienced diverse negative effects from the North Atlantic hurricane season, including deadly storms like Hurricane Maria in 2017. Vulnerability is increased by geographic location, small island developing state (SIDS) status, and ecosystem characteristics. A variety of negative health effects including stress and anxiety are caused by powerful storms. The perspectives of middle-aged (the “sandwich generation”) survivors in this post-storm milieu are understudied.MethodsThis phenomenological qualitative study describes the perceptions of middle-aged (35–55 years) Dominicans, purposively recruited with gatekeeper assistance from communities stratified according to four natural hazard vulnerability categories designated by the Climate Resilience Execution Agency for Dominica (CREAD), regarding their lived experiences in the context of severe storms. Data was collected between June and August 2022, using primarily Zoom-based semi-structured, individual interviews (12 of 13), guided by the principles of saturation and maximum variation. Verbatim interview transcripts were thematically analyzed with constant comparison using an ATLAS.ti-supported hybrid deductive-inductive coding frame. Reflexivity and contact summary sheets were used to minimize bias.ResultsTen women and three men from diverse CREAD vulnerability and sociodemographic backgrounds were recruited. Data condensation yielded three organizing themes: (i) “The diverse health effects of severe storms”, (ii) “Response to and recovery from severe storms”, and (iii) “Preparedness and precaution for severe storms”. These themes encapsulated the health impacts of severe storms on Dominicans and elucidated the role of facilitating and barricading resilience factors.DiscussionSevere storms produced direct and indirect mental, social, and physical health impacts on middle-aged Dominicans, including anxiety and burnout. Participants used faith-based, tangible community-based support, and emotional mechanisms to cope with and demonstrate resilience. Better risk communication and early warning systems would improve population readiness. Persistent dispirited attitudes toward storm preparedness among some participants suggest the need for targeted methods to enhance community involvement in disaster planning, including traditional approaches like “coup-de-main” (self-help).

This article examines the historical practice of overlaying, which is the accidental suffocation of infants while sharing a bed with adults. The study focuses on archival records from Tasmania in the 19th century and finds that 128 deaths were attributed to overlaying during this time period. The deaths showed a seasonal pattern, with more occurring in winter. The article highlights the need to consider different populations and risk factors when studying infant deaths. [Extracted from the article]

The management of fish aggregating devices (FAD) creates heated debates in tuna fishery management organizations striving to reduce the number of deployed floating objects. Through several econometric models and a machine learning approach, we evaluate the consequences of three management scenarios on the catch and profit of the French purse‐seine fleet operating in the Indian Ocean: (1) a half reduction in the number of authorized buoys per vessel, (2) a 72‐day closure of FAD fishing with and (3) without re‐allocation of effort on free schools. The results show a significant decrease of fleet profits by 7%, 10% and 18% respectively. We hypothesize an "economic trap" of FAD fishing caused by the far greater efficiency of this harvesting technique for larger vessels searching for economies of scale, and by the overfished status and catch limitation of yellowfin (Thunnus albacares) and bigeye (Thunnus obesus) tunas in the Indian Ocean. The results are compared with other studies looking at the impact of FAD management measures in other oceans. [ABSTRACT FROM AUTHOR]

Ciguatera, a global issue, lacks adequate capacity for ciguatoxin analysis in most affected countries. The Caribbean region, known for its endemic ciguatera and being home to a majority of the global small island developing states, particularly needs established methods for ciguatoxin detection in seafood and the environment. The radioligand receptor binding assay (r-RBA) is among the in vitro bioassays currently used for ciguatoxin analysis; however, similarly to the other chemical-based or bioassays that have been developed, it faces challenges due to limited standards and interlaboratory comparisons. This work presents a single laboratory validation of an r-RBA developed in a Cuban laboratory while characterizing the performance of the liquid scintillation counter instrument as a key external parameter. The results obtained show the assay is precise, accurate and robust, confirming its potential as a routine screening method for the detection and quantification of ciguatoxins. The new method will aid in identifying high-risk ciguatoxic fish in Cuba and the Caribbean region, supporting monitoring and scientific management of ciguatera and the development of early warning systems to enhance food safety and food security, and promote fair trade fisheries. [ABSTRACT FROM AUTHOR]

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Copyright of Die Pathologie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The extensive and rapid development of the human brain during the first years of life complicates the postmortem diagnosis of brain edema in infancy. The aim of this study was to describe brain water content, the brain weight/body weight ratio, and the brain weight/head circumference ratio throughout the first years of life. Furthermore, we examined the relationship between these parameters and rs2075575 in the AQP4 gene. Our hypothesis was that dysregulated water homeostasis might be a risk factor for sudden infant death syndrome (SIDS), which may be reflected by increased water content in the brain. The study included 90 subjects with sudden unexpected death < 4 years of age: 22 cases of sudden infant death syndrome, 11 cases of sudden unexplained death in childhood, 47 cases of death due to disease, and 10 cases of accident/violent death. Brain water content, brain weight/body weight ratio, and brain weight/head circumference ratio were investigated according to corrected age, diagnosis group, attempt to resuscitate, and presence of brain edema. We found that brain water content and brain weight/body weight ratio were significantly reduced with increasing age, while brain weight/head circumference were increased. Brain weight/head circumference was correlated with brain water content. Cases with brain edema had a significantly higher brain weight/head circumference than the non-edematous cases. No differences were found between the diagnosis groups for any of the investigated parameters. In summary, the findings contribute to the current body of knowledge regarding brain growth during the first months of life. [ABSTRACT FROM AUTHOR]

The electrical power and land transportation systems of the Dominican Republic are facing significant challenges due to growing demand in both sectors. These two systems are responsible for around 62% of greenhouse gas (GHG) emissions. With the deployment of electric mobility, the power and transport sectors can synergise and contribute significantly to long-term sustainable planning. This article analyses the impact of the penetration of electric mobility programmed by the Dominican Republic's National Institute of Transit and Land Transport (INTRANT), the country's goal of reducing GHG emissions by 27% by 2030 and the decarbonisation process. Using the open-source modelling system OSeMOSYS, four scenarios are built to explore strategies that contribute to sustainable development in the long term. Meeting climate change commitments necessitates that all coal-fired plants in the country will be closed or transformed by 2040. Despite the positive role of electric mobility in reducing GHG, decarbonising the electricity sector while facing the energy crisis requires investments totalling around 16 billion USD. Failing to make these investments will incur expenses of approximately 6 billion USD on the user's side in the period from 2024 to 2030 to cover energy needs; this figure represents more than 270% of the amount that should be invested in the electrical power system to supply these users' needs.

Aim:The bed-sharing option has been reported to positively encourage breastfeeding frequency in the literature. However, an association between sudden infant death syndrome (SIDS) and infant bed-sharing has also been identified. The present study aimed to determine the effects of mother-infant bed-sharing and room-sharing on breastfeeding and sleep patterns and whether there is any increased risk of SIDS.Materials and Methods:We conducted a cross-sectional study among 507 mother-infant dyads between August, 2017 and August, 2018. Bed-sharing was defined as sharing a bed or mattress; room-sharing was defined as sharing the same room for any part of the night. The validated Sleep Questionnaire form was used to assess infant sleep characteristics. Potential predictors of bed-sharing were evaluated via logistic regression models (age, education, etc.).Results:In the study period, 507 mother-infant dyads were included. The rate of room-sharing was 78.1%, and the rate of bed-sharing was 12.4%. Additionally, the rate of sleeping in a different room was 9.5%. All infants aged 1-5 months who shared a bed with their mother were breastfed, while 94% of those who did not share a bed were breastfed. For 6-12-month-old babies, the breastfeeding frequency was 86% for those who shared a bed, whereas 77% of those who did not share a bed were breastfed. However, the bed-sharing modality was not statistically shown to increase the frequency of breastfeeding [odds ratio (95% confidence interval); 0.362 (0.130-1.01)] (p=0.052).Conclusion:Sharing a bed remains popular for infants’ sleep arrangements. In our study, the majority of infants slept in separate cribs. This study revealed that mother-infant bed sharing increased breastfeeding frequency. Moreover, mother-infant bed sharing delayed the age at which babies with sleep disorders stopped breastfeeding.

This study aimed to investigate, for the first time, the potential role of the gigantocellular nucleus, a component of the reticular formation, in the pathogenetic mechanism of Sudden Infant Death Syndrome (SIDS), an event frequently ascribed to failure to arouse from sleep. This research was motivated by previous experimental studies demonstrating the gigantocellular nucleus involvement in regulating the sleep–wake cycle. We analyzed the brains of 48 infants who died suddenly within the first 7 months of life, including 28 SIDS cases and 20 controls. All brains underwent a thorough histological and immunohistochemical examination, focusing specifically on the gigantocellular nucleus. This examination aimed to characterize its developmental cytoarchitecture and tyrosine hydroxylase expression, with particular attention to potential associations with SIDS risk factors. In 68% of SIDS cases, but never in controls, we observed hypoplasia of the pontine portion of the gigantocellular nucleus. Alterations in the catecholaminergic system were present in 61% of SIDS cases but only in 10% of controls. A strong correlation was observed between these findings and maternal smoking in SIDS cases when compared with controls. In conclusion we believe that this study sheds new light on the pathogenetic processes underlying SIDS, particularly in cases associated with maternal smoking during pregnancy.

The authors describe a case of fetal isolated right atrial enlargement or IDRA (idiopathic dilatations of the right atrium) evident in third trimester, complicated by arrhythmia in the female infant during the 1° month of life with ECG diagnosis of Wolf-Parkinson-White syndrome (WPW). The eldest sister died at 6 years because of an arrhythmia with the same diagnosis of WPW. The review of the literature on IDRA frequently shows a familial genetic aggregation. The pathogenetic mechanism underlying the dilation of the right atrium could consist of a myopathy or electrical conduction disorder. The exclusive involvement of the right atrium may be due to the increased pressure in the fetal right atrium. On the basis of our case and after review of the literature, we must be careful in defining as physiological the enlargement of the right fetal atrium in the third trimester of pregnancy. The ultrasound sign of IDRA may be a fetal prodrome of SIDS (sudden infant death syndrome). [ABSTRACT FROM AUTHOR]

The "blue economy" idea promotes the responsible and sustainable use of coastal and marine resources. The need to balance the exploitation and economic use of these resources has moved to the top of the research agenda and management priorities for small island developing states (SIDS). SIDS face unique challenges due to their geographic, economic, and environmental characteristics. While the specific challenges can vary based on the individual SIDS, some common future challenges include (i) climate change and sea-level rise resulting from the increased frequency and intensity of storms and coastal erosion; (ii) natural disasters such as hurricanes, cyclones, tsunamis, and earthquakes, resulting in extensive damage, disruption of essential services, and lead to loss of lives and livelihoods; (iii) lack of sustainable development and economic diversification leading to reliance on few key sectors, such as tourism and agriculture, which are vulnerable to market fluctuations; (iv) energy security and renewable energy transition; as there is dependency on imported fossil fuels for their energy needs, price fluctuations and supply disruptions occurs; (v) biodiversity conservation and marine resource management; they host unique ecosystems and rich biodiversity, including coral reefs, mangroves, and marine species; and (vi) access to finance and technology; there are direct opportunities, for accessing funds to support technology development under sustainable finance projects. This themed article set attracted 14 submissions, 7 of which were accepted for publication. The topics covered fisheries, climate change effects, marine litter, and development of new technologies and finance mechanisms to support the SIDS. Overall, these contributions have emphasized the remarkable role that SIDS play in the protection and management of coastal and marine ecosystems, but also highlighted several needs and key priorities. [ABSTRACT FROM AUTHOR]

Aim: The bed-sharing option has been reported to positively encourage breastfeeding frequency in the literature. However, an association between sudden infant death syndrome (SIDS) and infant bed-sharing has also been identified. The present study aimed to determine the effects of mother-infant bed-sharing and room-sharing on breastfeeding and sleep patterns and whether there is any increased risk of SIDS. Materials and Methods: We conducted a cross-sectional study among 507 mother-infant dyads between August, 2017 and August, 2018. Bedsharing was defined as sharing a bed or mattress; room-sharing was defined as sharing the same room for any part of the night. The validated Sleep Questionnaire form was used to assess infant sleep characteristics. Potential predictors of bed-sharing were evaluated via logistic regression models (age, education, etc.). Results: In the study period, 507 mother-infant dyads were included. The rate of room-sharing was 78.1%, and the rate of bed-sharing was 12.4%. Additionally, the rate of sleeping in a different room was 9.5%. All infants aged 1-5 months who shared a bed with their mother were breastfed, while 94% of those who did not share a bed were breastfed. For 6-12-month-old babies, the breastfeeding frequency was 86% for those who shared a bed, whereas 77% of those who did not share a bed were breastfed. However, the bed-sharing modality was not statistically shown to increase the frequency of breastfeeding [odds ratio (95% confidence interval); 0.362 (0.130-1.01)] (p=0.052). Conclusion: Sharing a bed remains popular for infants' sleep arrangements. In our study, the majority of infants slept in separate cribs. This study revealed that mother-infant bed sharing increased breastfeeding frequency. Moreover, mother-infant bed sharing delayed the age at which babies with sleep disorders stopped breastfeeding. [ABSTRACT FROM AUTHOR]

Objective Investigate whether safe infant sleep prioritization by states through the Title V Maternal and Child Block Grant in 2010 differentially impacted maternal report of supine sleep positioning (SSP) for Non-Hispanic White (NHW) and Non-Hispanic Black (NHB) U.S.-born infants. Study Design We analyzed retrospective cross-sectional data from the Pregnancy Risk Assessment Monitoring System (PRAMS) from 2005 to 2015 from 4 states: WV and OK (Intervention) and AR and UT (Control). PRAMS is a population-based surveillance system of maternal perinatal experiences which is linked to infant birth certificates. Piece-wise survey linear regression models were used to estimate the difference in the change in slopes of SSP percents in the pre- (2005–2009) and post- (2011–2015) periods, controlling for maternal and infant characteristics. Models were also stratified by race/ethnicity. Results From 2005 to 2015, for NHW infants, SSP improved from 61.5% and 70.2% to 82.8% and 82.3% for intervention and control states, respectively. For NHB infants, SSP improved from 30.6% and 26.5% to 64.5% and 53.1% for intervention and control states, respectively. After adjustment for maternal characteristics, there was no difference in the rate of SSP change from the pre- to post- intervention periods for either NHW or NHB infants in intervention or control groups. Conclusion Compared with control states that did not prioritize safe infant sleep in their 2010 Title V Block Grant needs assessment, intervention states experienced no difference in SSP improvement rates for NHW and NHB infants. While SSP increased for all infants during the study period, there was no causal relationship between states' prioritization of safe infant sleep and SSP improvement. More targeted approaches may be needed to reduce the racial/ethnic disparity in SSP and reduce the risk for sleep-associated infant death. Key Points Supine sleep positioning improved for Black and White infants in the U.S. State prioritization of safe infant sleep did not directly impact SSP for NHB or NHW infants. More targeted approaches may be needed to reduce racial/ethnic disparities in safe sleep practices [ABSTRACT FROM AUTHOR]

Important development partners encouraged and supported the development of Caribbean islands' recent action plans and targets on climate change and health. These developments are part of larger global trends around mainstreaming climate change adaptation into national health policy. Including community voices is crucial, yet the responsiveness of regional and national processes around climate change adaptation and health governance to local community concerns is poorly understood. This case study in rural Trinidad and Tobago sought to contribute to better understanding community led action on health and climate change adaptation by investigating community groups' perceptions of the challenges faced and addressed by their community. The study contributes to climate change adaptation and health debates in three main ways. First, it develops a conceptual framework around agency in the context of health and climate change adaptation in community groups and local spaces. Second, it fills a gap in the literature by registering the voices and perspectives of coastal community groups regarding their development priorities in the context of climate change adaptation and health. Third, using the lens of agency, it highlights the disconnect between local voices and the urgency around the mainstreaming of climate change adaptation and health into regional and national climate change adaptation policies. This study contributes to wider debates around the power of external agents to shape local discourses and policy. The results contrast dominant global narratives underlying recent regional and national policies and suggest that this area is still one where there may be a disconnect between local development priorities and international policy. • Rural community groups have unique insights on climate and health. • Rural community groups should have more agency in climate and health policy. • There is a disconnect between local community priorities and regional and national climate-health goals. • Rural community groups felt alienated from climate-health governance processes. • Rural community action requires external support for sustainable development. [ABSTRACT FROM AUTHOR]

Abstract Background There is very little information on the beliefs and perceptions of mothers about SIDS and its related risk factors in Africa. To better understand parental decisions about infant sleep practices and other risk factors for SIDS, we conducted focus group discussions (FGDs) with mothers of infants in Lusaka, Zambia. Methods FGDs involved 35 purposively sampled mothers aged 18–49 years. FGDs were conducted using a semi-structured interview guide in the local language, Nyanja. These were translated, transcribed verbatim into English, and then coded and analyzed using thematic analysis in NVivo 12. Results Six FGDs were conducted with 35 mothers in April-May 2021 across two study sites. FGD Participants were generally aware of sudden unexplained infant deaths, with several describing stories of apparent SIDS in the community. The side sleeping position was preferred and perceived to be safer for the infant with most believing the supine position posed an aspiration or choking risk to the infant. Bedsharing was also preferred and perceived to be convenient for breastfeeding and monitoring of the infant. Experienced family members such as grandmothers and mothers-in-law, and health care workers were frequently cited as sources of information on infant sleep position. A heightened awareness of the infant’s sleeping environment was suggested as a mechanism to prevent SIDS and smothering. Conclusions Decisions about bedsharing and infant sleep position were guided by maternal beliefs and perceptions about what is convenient for breastfeeding and safer for the infant. These concerns are vital to designing tailored interventions to address sleep-related sudden infant losses in Zambia. Public health campaigns with tailored messages that address these concerns are likely to be effective at ensuring optimal uptake of safe sleep recommendations.

To achieve coral reef resilience under Agenda 2030, island governments need to institutionalise a competent blue workforce to expand their reef resilience initiatives across economic organisations and industries. The ability of island governments to shape new policies for sustainable island development relying on natural capital, such as coral reefs, has been hampered by structural and institutional deficiencies on both sides of the science-policy interface (SPI) at the UN. Using a qualitative research design, this article explores the science-policy interface (SPI) policy paper, Rebuilding Coral Reefs: A Decadal Grand Challenge and the role of this SPI in guiding UN coral reef financing for island states. This article uses the dive industry to investigate the needs of policymakers in island states via a conceptual framework for policy analysis. This article highlights the gaps of the SPI from the perspective of the global south and is beneficial for the islands selected under the Global Coral Reef Investment Plan. The article highlights the results of the SPI to island decision makers, which indicate that, without a policy framework that includes space for industrial policy within UN SPI, island governments will continue to fall into financial traps that constrain their efforts in operationalising their blue workforce. The study concludes that interlinked SDGs, such as SDG 9 and SDG 8, which focus on linking industrial innovation and infrastructure with decent work, as well as SDG 16 and 14.7, provide SIDS institutions with integrated policy approaches capable of bridging the divides between the scientific community, the diving industry, and island governments and that this needs to be further explored at all levels.

In an increasingly uncertain world, water is constant and central to most things: the economy, energy, transport, agriculture, health, leisure, wellbeing, social and cultural life. The 7th Water Efficiency (WATEF) Conference 2022 was, for the first time, held outside Europe in the Caribbean, at the Faculty of Engineering, The University of the West Indies, Saint Augustine Campus, Trinidad and Tobago on 14th-16th December, 2022. Many challenges reflect the changing climate, increasingly unpredictable weather, and the efforts towards sustainable development necessary for social equity and economic growth. Proactive partnerships and collaborations across civil society is necessary to succeed in this effort. A conference on water efficiency and resilience is justified in the face of these challenges and during an energy, cost-of-living, food, and other crises. The WATEF-2022 Conference’s theme was “Water Resources Resilience for Small Island Developing States (SIDS)”. Trinidad and Tobago has a relatively high reliable water infrastructure (including desalination plants) for its population but in recent times water resources have been impacted by unforeseen climate change events. This twin-island republic was best suited for this conference, geographically and technically. Parallel with invited keynotes and feature speeches, technical presentations and panel discussions were made addressing various topics and areas associated with the conference’s theme. This paper contains a total of 28 abstracts excerpted from the Conference proceedings that address towards collaborative solutions to the water and resilience challenges faced globally and experienced more intensely by SIDS. [ABSTRACT FROM AUTHOR]