Search

Your search keyword '"SHIMIZU, YOSHIO"' showing total 635 results
Start Over Author "SHIMIZU, YOSHIO"
635 results on '"SHIMIZU, YOSHIO"'

3. IgA Nephropathy: Beyond the Half-Century.

Author

Shimizu, Yoshio, Tomino, Yasuhiko, and Suzuki, Yusuke

Subjects
IGA glomerulonephritis, RENIN-angiotensin system, IMMUNE complexes, PLASMA cells, DRUG target
Abstract

In 1968, Jean Berger first introduced the medical world to IgA nephropathy (IgAN). Fifty-five years later, its pathogenesis is still unclear, but treatments such as renin–angiotensin–aldosterone system inhibitors (RAAS-Is), tonsillectomies, and glucocorticoids are currently used worldwide. There have been great strides in the past 20 years since the discoveries of the specific dysregulation of mucosal immunity, galactose-deficient IgA1 (Gd-IgA1), and Gd-IgA1 immune complexes in patients with IgAN. According to these findings, a multi-hit hypothesis was developed, and this multi-hit hypothesis has provided several putative therapeutic targets. A number of novel agents, including molecularly targeted drugs for targets such as APRIL, plasma cells, complement systems, and endothelin, are undergoing clinical trials. Some candidate drugs have been found to be effective, with minimal side effects. Over half a century after the discovery of IgAN, these therapies will soon be available for clinical use. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

14. The Influence of an Unexpected Switch of Hemodialysis Facilities on the Quality of Life (QOL) in Hemodialysis Patients

Author

Shimizu,Yoshio, Wakabayashi,Keiichi, Nakata,Junichiro, Io,Hiroaki, Hamada,Chieko, Tomino,Yasuhiko, Suzuki,Yusuke, Shimizu,Yoshio, Wakabayashi,Keiichi, Nakata,Junichiro, Io,Hiroaki, Hamada,Chieko, Tomino,Yasuhiko, and Suzuki,Yusuke

Abstract

Yoshio Shimizu,1,2 Keiichi Wakabayashi,1 Junichiro Nakata,3 Hiroaki Io,4 Chieko Hamada,5 Yasuhiko Tomino,6 Yusuke Suzuki3 1Department of Nephrology, Juntendo University Shizuoka Hospital, Izunokuni-shi, 410-2211, Japan; 2Shizuoka Medical Research Center for Disaster, Izunokuni-shi, 410-2211, Japan; 3Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Tokyo, 113-8421, Japan; 4Division of Nephrology, Juntendo University Nerima Hospital, Tokyo, 117-8521, Japan; 5Juntendo University Faculty of Health Sciences and Nursing, Mishima-shi, 411-8787, Japan; 6Asian Pacific Renal Research Promotion Office, Medical Corporation SHOWAKI, Tokyo, 160-0023, JapanCorrespondence: Yoshio Shimizu, Division of Nephrology, Department of Internal Medicine, Juntendo University Shizuoka Hospital, 1129 Nagaoka, Izunokuni-shi, Shizuoka, 410-2211, Japan, Tel +81-55-948-3111, Fax +81-55-946-0858, Email yosimizu@juntendo.ac.jpBackground: We experienced a sudden breakdown of hemodialysis system during a clinical study of dermal itch and serum BNP concentrations.Patients and Methods: Forty-eight hemodialysis patients were enrolled in the itch-related study. It was intended to improve itch by lowering BNP with supportive communication between the patients and the dialysis staff. We planned to collect data, including visual analogue scale (VAS), dermatology life quality index (DLQI), blood samples and QOL score (KDQOL-SF), four times over a four week interval. The first data was obtained just prior to switching facilities due to a breakdown. The patients underwent hemodialysis in other facilities for two weeks and underwent determination of their clinical data, including QOL scores, three times.Results: While mean blood pressure showed no significant differences, serum albumin, iron and phosphate levels were worsened significantly between pre- and post-relocation. Serum BNP and DLQI showed no significant changes. VAS was significantly worsened. The mean va

Published
2022

15. Post-Operative Kidney Function Using Deep Hypothermic Circulatory Arrest (DHCA) in Aortic Arch Operation

Author

Higo,Masahide, Shimizu,Yoshio, Wakabayashi,Keiichi, Nakano,Takehiko, Tomino,Yasuhiko, Suzuki,Yusuke, Higo,Masahide, Shimizu,Yoshio, Wakabayashi,Keiichi, Nakano,Takehiko, Tomino,Yasuhiko, and Suzuki,Yusuke

Abstract

Masahide Higo,1 Yoshio Shimizu,2,3 Keiichi Wakabayashi,2 Takehiko Nakano,1 Yasuhiko Tomino,4 Yusuke Suzuki5 1Department of Clinical Engineering, Juntendo University Shizuoka Hospital, Izunokuni, Shizuoka, Japan; 2Division of Nephrology, Department of Internal Medicine, Juntendo University Shizuoka Hospital, Izunokuni, Shizuoka, Japan; 3Shizuoka Medical Research Center for Disaster, Juntendo University, Izunokuni, Shizuoka, Japan; 4Asian Pacific Renal Research Promotion Office, Medical Corporation SHOWAKAI, Shinjuku-ku, Tokyo, Japan; 5Department of Nephrology, Juntendo University Faculty of Medicine, Tokyo, JapanCorrespondence: Yoshio Shimizu, Division of Nephrology, Department of Internal Medicine, Juntendo University Shizuoka Hospital, 1129 Nagaoka, Izunokuni-shi, Shizuoka, 410-2211, Japan, Tel +81-55-948-3111, Fax +81-55-946-0858, Email yosimizu@juntendo.ac.jpBackground: Although deep hypothermic circulatory arrest (DHCA) is a useful option to protect the central nervous system during aortic arch operations, the influence of simultaneous renal ischemia remains controversial.Patients and Methods: This is a retrospective observational study. Sixty-three patients who underwent thoracic aortic surgery with DHCA and 24 patients who underwent cardiac surgery without DHCA were included in this study. The mean age, preoperative serum creatinine (Cr) level, preoperative estimated glomerular filtration rate (eGFR), peak serum Cr level up to 48 hrs post-operative, elevation rate of Cr compared to the preoperative serum Cr, urine volume rate up to 48 hrs post-operative and AKI staging using the KDIGO criteria were estimated for each patient. Clinical parameters for 3 months after the operation and the 3-month post-operative mortality rate were assessed. Mean values indicating kidney function or distribution of the AKI stages were compared between patients with and without DHCA. Patients with DHCA were further divided according to the duration of ischemia to compare the values

Published
2022

35. Oxidative stress and Liver X Receptor agonist induce hepatocellular carcinoma in Non‐alcoholic steatohepatitis model

Author

Shimizu, Yoshio, primary, Tamura, Takafumi, additional, Kemmochi, Akira, additional, Owada, Yohei, additional, Ozawa, Yusuke, additional, Hisakura, Katsuji, additional, Matsuzaka, Takashi, additional, Shimano, Hitoshi, additional, Nakano, Noriyuki, additional, Sakashita, Shingo, additional, Oda, Tatsuya, additional, and Ohkohchi, Nobuhiro, additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results