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675 results on '"SHIBUYA N"'

9. Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology

Author

Ide, M, Ohnishi, T, Toyoshima, M, Balan, S, Maekawa, M, Shimamoto-Mitsuyama, C, Iwayama, Y, Ohba, H, Watanabe, A, Ishii, T, Shibuya, N, Kimura, Y, Hisano, Y, Murata, Y, Hara, T, Morikawa, M, Hashimoto, K, Nozaki, Y, Toyota, T, Wada, Y, Tanaka, Y, Kato, T, Nishi, A, Fujisawa, S, Okano, H, Itokawa, M, Hirokawa, N, Kunii, Y, Kakita, A, Yabe, H, Iwamoto, K, Meno, K, Katagiri, T, Dean, B, Uchida, K, Kimura, H, Yoshikawa, T, Ide, M, Ohnishi, T, Toyoshima, M, Balan, S, Maekawa, M, Shimamoto-Mitsuyama, C, Iwayama, Y, Ohba, H, Watanabe, A, Ishii, T, Shibuya, N, Kimura, Y, Hisano, Y, Murata, Y, Hara, T, Morikawa, M, Hashimoto, K, Nozaki, Y, Toyota, T, Wada, Y, Tanaka, Y, Kato, T, Nishi, A, Fujisawa, S, Okano, H, Itokawa, M, Hirokawa, N, Kunii, Y, Kakita, A, Yabe, H, Iwamoto, K, Meno, K, Katagiri, T, Dean, B, Uchida, K, Kimura, H, and Yoshikawa, T

Abstract

Mice with the C3H background show greater behavioral propensity for schizophrenia, including lower prepulse inhibition (PPI), than C57BL/6 (B6) mice. To characterize as-yet-unknown pathophysiologies of schizophrenia, we undertook proteomics analysis of the brain in these strains, and detected elevated levels of Mpst, a hydrogen sulfide (H2 S)/polysulfide-producing enzyme, and greater sulfide deposition in C3H than B6 mice. Mpst-deficient mice exhibited improved PPI with reduced storage sulfide levels, while Mpst-transgenic (Tg) mice showed deteriorated PPI, suggesting that "sulfide stress" may be linked to PPI impairment. Analysis of human samples demonstrated that the H2 S/polysulfides production system is upregulated in schizophrenia. Mechanistically, the Mpst-Tg brain revealed dampened energy metabolism, while maternal immune activation model mice showed upregulation of genes for H2 S/polysulfides production along with typical antioxidative genes, partly via epigenetic modifications. These results suggest that inflammatory/oxidative insults in early brain development result in upregulated H2 S/polysulfides production as an antioxidative response, which in turn cause deficits in bioenergetic processes. Collectively, this study presents a novel aspect of the neurodevelopmental theory for schizophrenia, unraveling a role of excess H2 S/polysulfides production.

Published
2019

10. P081 Effect of bile acid on lymphocyte migration in the small intestine

Author

Shibuya, N, primary, Higashiyama, M, additional, Nishii, S, additional, Mizoguchi, A, additional, Inaba, K, additional, Sugihara, N, additional, Hanawa, Y, additional, Wada, A, additional, Horiuchi, K, additional, Furuhashi, H, additional, Kurihara, C, additional, Hozumi, H, additional, Okada, Y, additional, Watanabe, C, additional, Komoto, S, additional, Tomita, K, additional, Nagao, S, additional, Saruta, M, additional, and Hokari, R, additional

Published
2019
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15. A Wireless Gait Analysis Sensor for Real-Time Robust Fall Detection Using an Artificial Neural Network

Author

Lie, Donald, Nukala, B. T., Shibuya, N., Rodriguez, A. I., Tsay, J., Nguyen, T. Q., Zupancic, S., and Lie, D. Y. C.

Abstract

This paper describes our custom-designed wireless gait analysis sensor (WGAS) system developed and tested for real-time fall detection. The WGAS is capable of differentiating falls vs. Activities of Daily Living (ADL) and the Dynamic Gait Index (DGI) performed by young volunteers using a Back Propagation Artificial Neural Network (BP ANN) algorithm. The WGAS, which includes a tri-axial accelerometer, 2 gyroscopes, and a MSP430 microcontroller is worn by the subjects at either T4 (at back) or the belt-clip positions (in front of the waist) for the various falls, ADL, and Dynamic Gait Index (DGI) tests. The raw data is wirelessly transmitted from the WGAS to a nearby PC for real-time fall classification, where six features were extracted for the BP ANN. Overall fall classification accuracies of 97.0% and 97.4% have been achieved for the data taken at the T4 and at the belt position, respectively. The preliminary data demonstrates an overall sensitivity of 97.0% and overall specificity of 97.2% for this WGAS fall detection system, showing good promise as a real-time low-cost and effective fall detection device for wireless acute care and wireless assisted living.

Published
2014

42. Elderberry Bark Lectins Evolved to Recognize Neu5Ac 2,6Gal/GalNAc Sequence from a Gal/GalNAc Binding Lectin Through the Substitution of Amino-Acid Residues Critical for the Binding to Sialic Acid

Author

Kaku, H., primary, Kaneko, H., additional, Minamihara, N., additional, Iwata, K., additional, Jordan, E. T., additional, Rojo, M. A., additional, Minami-Ishii, N., additional, Minami, E., additional, Hisajima, S., additional, and Shibuya, N., additional

Published
2007
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