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Objective To compare the efficacy and safety of programmed cell death protein 1 (PD-1) inhibitor + albumin paclitaxel and platinum + PD-1 inhibitor + albumin-paclitaxel in the treatment of advanced metastasis or recurrent cervical cancer. Methods The clinical data of patients who had advanced metastatic or recurrent cervical cancer were treated with PD-1 inhibitor + albumin paclitaxel + platinum (group A) or anti-PD-1 + albumin-bound paclitaxel (group B) in more than second-line therapy in the Affiliated Cancer Hospital of Nanjing Medical University from September 2018 to December 2022 were retrospectively analyzed. The objective response rate (ORR), progression-free survival (PFS) and the incidence of adverse reactions between the two groups were compared. Results A total of 54 patients were collected, 37 in group A and 17 in group B. The median age was 53 years old, and the average follow-up time was 10 months. Among the patients, 45 cases were squamous cell carcinoma, 6 cases were adenocarcinoma, 1 case was adenosquamous carcinoma, and 2 cases were neuroendocrine small cell carcinoma. There was no statistically significant difference in the ORR between group A and group B (35.30% vs 35.14%, P>0.05). There was no statistical significant difference in PFS between group A and group B (11.7 month vs 7.3 month, P>0.05). The differences in the incidence of adverse reactions, the incidence of adverse reactions with grade 3 and above, and the incidence of immune-related adverse reactions between the two groups were not statistically significant (P>0.05). Conclusion The PD-1 inhibitor + albumin paclitaxel + platinum regimen does not increase the efficacy compared with the PD-1 inhibitor + albumin paclitaxel regimen in more than second-line therapy of advanced metastatic and recurrent cervical cancer.

【Objective】With the development of domestic optical network construction, the management of fiber optic cable routing resources increasingly attract the attention of operators, especially the problem of low efficiency in fiber optic cable survey. There is an urgent need for a feasible fiber optic cable survey method and plan to solve the current problems. The effectiveness and practicality of fiber optic cable routing survey methods are also important indicators that determine the improvement of network construction and maintenance indicators in the region.【Methods】The article investigates and analyzes the existing survey methods and laws of a large number of complex environmental optical cable routes. It also compares and analyzes the detection principles, application scenarios, and existing problems from multiple dimensions. The article focuses on evaluating efficiency improvement, operability, and cost. Combining with actual case situations, it analyzes the actual survey effects of different schemes in a targeted manner.【Results】The article innovatively proposes the research concept of a new fiber optic cable survey method and its application in multiple types of scenarios. The focus is on the practical application of cable identification instruments and cable knocking survey instruments that can be used for full process identification. They have advantages in efficiency and cost, and can solve the pain points of pipeline resource management for operators, providing ideas for the informational development and innovation of pipeline resources for domestic operators.【Conclusion】The method of fiber optic cable routing survey are important breakthroughs in effectively solving practical problems such as cable laying, cable inspection, and cable repair, which are important links in the construction of high-quality optical networks.

Runoff simulation has always been a research hotspot in hydrological science, which has important guiding significance for water resources research. Based on the extreme gradient boosting (XGBoost) algorithm and soil and water assessment tool (SWAT) model, a runoff simulation model was constructed by using the observed hydrological data of Waizhou hydrological station in Ganjiang River Basin, and the simulation effects of the two models were compared. Meanwhile, based on the XGBoost model, the residual correction method was used to correct the runoff simulation results of the SWAT model. The results show that: ① The simulation effect of the XGBoost model is good, and the Nash-Sutcliffe efficiency (NSE) of daily runoff simulation of the XGBoost model is 15.66% higher than that of the SWAT model. ② The SWAT model is underestimated at high flow rates, while the XGBoost model results in basically consistent simulation values and observed values, and the simulated hydrograph has a high degree of fitting, showing a good correlation. ③ After XGBoost correction, the simulation accuracy of the SWAT model is obviously improved, which can effectively improve the runoff simulation effect. When the residual error is corrected, the NSE value of runoff simulation can reach 0.96, an increase of 15.66%.

Surface guided radiation therapy (SGRT) is a non-radiation, non-invasive technology that provides continuous postural monitoring of patients during radiotherapy. Using advanced 3D optical surface localization and tracking technology, SGRT quickly captures the surface contour information of patients through optical means to generate high-precision 3D surface contours, enabling real-time monitoring of patients during radiotherapy to ensure its accuracy. This image-guided technology has been widely applied in radiotherapy for tumors in different parts of the body, such as breast, intracranial, head and neck, and limbs. SGRT can reduce initial setup errors and provide real-time monitoring during treatment, or be combined with respiratory gating and deep inspiration breath-hold techniques. SGRT can also reduce radiation dose by reducing the use of CBCT, improve patient comfort with the use of immobilization devices, and enhance clinical speed, efficiency, and safety. This review aims to provide an overview of the commonly used technology and clinical applications of SGRT, and discuss its current limitations and future prospects.

ObjectiveTo explore the correlation between skeletal muscle mass and metabolic syndrome （MS） disease risk among middle-aged and elderly community residents in Urumqi， and to provide a theoretical basis for understanding the relationship between skeletal muscle mass and MS among middle-aged and elderly community residents in China.MethodsA total of 1 438 community residents ≥ 50 years old were selected as the research subjects from July 2018 to January 2019 in Urumqi. They were selected from a multi-ethnic natural population cohort in Xinjiang. Data were collected through questionnaires， physical examination， bioelectrical impedance analysis （BIA）， laboratory tests， etc. Skeletal muscle mass was evaluated using the limb skeletal muscle mass index （SMI） corrected for body weight； MS was defined as it at least includes three of the following： abdominal obesity， hypertension， hyperglycemia， high triglycerides and low high-density lipoprotein cholesterol. SMI was divided into four quantile arrays of Q1‒Q4. Trend χ2 test was applied to explore whether there was a correlation between SMI changes and MS. A multivariate logistic regression model was used to analyze whether there is a difference in the risk of MS between the higher SMI group （Q2， Q3， Q4） and the reference group Q1.ResultA total of 560 MS patients were detected in this study， with a prevalence rate of 38.94%. Among them， the prevalence rate of MS was 39.16% in males and 38.80% in females. The increase in male SMI grading level is not correlated with the prevalence of MS （trend P>0.05）； After adjusting for confounding factors （model 4）， the increase in SMI was still not related to the prevalence of MS （Ptrend=0.995）. There was no statistical difference in the risk of MS between the lowest quartile group Q1 and the highest quartile group Q4 （OR=1.01， 95%CI： 0.69‒1.78）. The prevalence of MS in women gradually decreased with the increase of SMI grading level （Ptrend

This paper reports the first case of myelodysplastic syndromes combined with myeloid sarcoma for which the department of radiotherapy used total marrow and lymphoid irradiation (TMLI) to assist in myeloablating. Radiotherapy localization and target area delineation were carried out before treatment and the entire process of TMLI treatment was designed using the TOMO therapy. Radiotherapy was performed successfully for targeted irradiation of the total bone marrow and lymph nodes. The patient felt comfortable during the treatment process and good pretreatment effects were achieved. The treatment time (45 min-1 h per session) was significantly shorter than that during total body irradiation (TBI)(3-4 h per session), the irradiation dose rate (800 cGy/min) was significantly increased compared to TBI (5-30 cGy/min), and oral mucosal inflammation and gastrointestinal reactions were mild after treatment. This article discusses the treatment process of this case and TMLI technology, to provide reference for the whole process design and important parameters for further treatment of more patients.

Various exquisite graphic designs that can be seen everywhere beautify people’s vision and influence people’s visual aesthetics subtly. This paper starts with the visual aesthetic elements of graphic design and discusses the construction of visual aesthetic element systems in graphic design by analyzing the composition elements and aesthetic characteristics. Secondly, it proposes to use the biological visual perceptual machine model to process information through two visual pathways in a hierarchical manner. The features of graphic design images are expressed, stored, and extracted using the visual information model. Finally, the effectiveness of the bio-visual perceptual model applied to the construction of visual aesthetic elements of graphic design is verified by the Caltech5 database, Caltech256 database, and Scene15 database. The results show that the classification accuracy of the bio-visual perceptron model is 94.28%, 91.36%, and 99.75% in Caltech5, Caltech256, and Scene15 databases, respectively, which is 23.12% higher than the accuracy of other neural network models on average. The bio-visual perceptron model proposed in this paper can accurately detect the elemental features in complex graphic design, which provides a new idea and method for rapid detection and recognition for graphic design workers.

EMIF is an external storage interface on a DSP (digital signal processor) device, and this paper proposes a bridge chip design method based on the EMIF interface of the TMS320VC5510 circuit. The bridge chip contains low-speed peripherals I2C, UART and SDIO interface, while integrating IDO, ADC analog IP. This design has been fully EDA simulation and FPGA verification, and tapeout for silicon verification. The implementation test results show that the EMIF interface can communicate with the bridge chip without error, and realize the peripheral expansion function of the TMS320VC5510 circuit. The design method of this bridge chip greatly increases the flexibility of SoC design on the market, effectively reduces the design cycle, and saves design costs.

ObjectiveTo obtain the prevalence of sarcopenia in middle-aged and elderly people in Urumqi based on the 2020 updated based on the 2020 updated Consensus Report 2019 of Asian Working Group for Sarcopenia （AWGS2019）， and to further explore the association between sarcopenia and metabolic syndrome （MS）.MethodsA total of 1 438 middle-aged and elderly people （aged≥50 years） in Urumqi from July 2018 to January 2019 were selected as the research subjects. Data were collected by questionnaire survey， physical examination and laboratory test. Skeletal muscle mass，grip strength and 4 m walking speed were used to represent muscle mass， muscle strength and body function， respectively. Bioelectrical impedance analysis （BIA） was used to measure human body components. Based on the diagnostic criteria of sarcopenia recommended by AWGS2019， the prevalence of sarcopenia in people over 50 years old was obtained. Multivariate logistic regression model was used to explore the correlation between sarcopenia and MS in middle-aged and elderly people of different genders.ResultsThere were 194 patients with sarcopenia， with a prevalence of 13.49%. The prevalence was 15.56% in males and 12.12% in females. There was no significant difference in the prevalence of MS between male sarcopenia group （40.45%） and non-sarcopenia group （38.92%）， while the prevalence of MS in female sarcopenia group （39.04%） was higher than that in non-sarcopenia group （27.56%）. Multivariate logistic regression analysis showed that sarcopenia was a related factor of MS. Compared with non-sarcopenia， the risk of MS in male sarcopenia group was higher （OR=2.11，95%CI： 1.15‒3.88 ）.ConclusionSarcopenia increases the risk of MS in middle-aged and elderly people， with a greater risk in men. Fully understanding of sarcopenia is helpful to early identify high-risk groups of MS and prevent the occurrence of MS.

Objective To summarize the clinical experience of intensity-modulated radiotherapy(IMRT) for patients with giant pituitary adenoma, and to provide evidence for clinical treatment. Methods The data of patients with giant pituitary adenoma who received 6MV-X IMRT with linear accelerator (prescription dose of 56-60 Gy/28-30 fractions, 5 fractions per week) in the Department of Radiation Oncology of Peking Union Medical College Hospital from October 2012 to October 2018 were reviewed. Treatment outcomes were evaluated by the control rate of tumor growth, remission rate of endocrine hormone, and radiation-related complications. Results A total of 15 patients were included in this study. There were 8 males and 7 females with a median age of 32 years. The control rate of tumor growth was 93.3% (partial response in 11 cases, stable in 3 cases, and development of pituitary carcinoma in 1 case). Among the 7 patients with functional giant pituitary adenoma, 1 patient achieved complete remission of the level of endocrine hormone and 2 patients achieved partial remission. Four patients treated with radiotherapy plus temozolomide achieved partial remission (median remission time was 5 months), and the remission rate and remission time were better than those who did not receive temozolomide. During the follow-up period after radiotherapy, 4 patients were found having newly pituitary dysfunction. There were no new or aggravating visional impairment and visual field defects. Conclusion Intensity-modulated radiotherapy is an effective treatment for giant pituitary adenoma, which can reduce the tumor faster combined with temozolomide.

Abstract Background Neuroblastoma is a common extracranial malignant tumor in children. Its main treatment modality is a combination of chemotherapy, radiotherapy, and surgery. Given the advances in chemotherapy regimens and the widespread use of bone marrow transplantation over the decades, there has been improvement in treatment efficacy, which has led to prolonged patient survival. Accordingly, long-term complications have become a growing concern among physicians and patients. This study aimed to analyze the survival rate of patients with neuroblastoma and the risk factors for developing second malignant neoplasms (SMNs). Methods The SEER 18 Regs (1973–2015) and SEER 9 Regs (1973–2015) data of the surveillance, epidemiology, and end results (SEER) database of the US National Cancer Institute were adopted for survival and SMN analysis. Results The 5-, 10-, and 20-year overall survival rates of patients with neuroblastoma were 67%, 65%, and 62%, respectively. Among 38 patients with neuroblastoma who presented with SMNs, those with abdomen as the primary site accounted for the majority (63.2%), followed by those with thorax (26.3%) and other sites (10.5%). SMNs occurred more commonly in non-specific neuroblastoma (incidence: 0.87%) than ganglioneuroblastoma (incidence: 0.3%). Compared with the general population, the risk of SMN is significantly higher (SIR = 4.36). The risk of developing SMNs was significantly higher in the digestive system (SIR = 7.29), bones and joints (SIR = 12.91), urinary system (SIR = 23.48), brain and other nervous systems (SIR = 5.70), and endocrine system (SIR = 5.84). Multivariate analysis revealed that the year of diagnosis (OR = 2.138, 95% CI = 1.634–2.797, p

Objective: To analyze the results of irregular antibody detection in early and late pregnancy and to study its clinical significance and safety strategy. Methods: A total of 14 770 pregnant women visited Shanghai First Maternity and Infant Hospital from July 2018 to September 2019 were enrolled and detected for irregular antibodies in the first trimester (≤16 weeks) and late pregnancy (≥32 weeks). In pregnant women with positive irregular antibody, umbilical cord blood or venous blood of newborn infant were collected for the testing of hemolytic disease of fetus and newborn HDFN. Results: Of the 14 770 case of pregnant women, 63 cases had irregular antibodies detected in the early pregnancy, with a positive rate of 0.43%, while 97 cases had irregular antibodies detected in late pregnancy, with a positive rate of 0.66%( χ2=7.264, P< 0.05). The number of cases with irregular antibody detected increased by 34cases in late pregnancy, accounting for 35.05% of the total positive irregular antibody cases. Majority of irregular antibody detected were anti-M antibodies, accounting for 33.33% and 34.02% in early and late pregnancy, respectively. Anti-E antibodies accounted for 12.69% and 16.49%, respectively, while proportion of anti-D antibodies were 7.94% and 8.25%, respectively. The distribution of antibody types between early and late pregnancy was similar( χ2=2.269, P>0.05). Of the 63 cases with irregular antibodies detected in early pregnancy, the titration of antibody increased by 2 gradients in 11 cases at late pregnancy, and 7 of them reached ≥ 64. The 34 cases with irregular antibody newly detected in late pregnancy generally had lower titration of antibodies, with only 1 case with titration≥64. Amongthe fetus delivered by 97 pregnant women with irregular antibodies, 12 were confirmed having non-ABO-HDFN; 8 were delivered by pregnant women with irregular antibody detected at early pregnancy, and 6 of the 8 were of the RH system (anti-D5, anti-Ec1), with more severe symptoms requiring blood transfusion or exchange transfusion. The 4 fetuses with non-ABO-HDFN delivered by women with irregular antibody newly detected at late pregnancy had mild symptoms. Conclusions: The detection rate of irregular antibody in late stage of pregnancy in Shanghai is obviously higher than that in early stage of pregnancy. Higher titer of antibody in early stage of pregnancy may result in serious HDFN. Retesting of irregular antibody in late pregnancy has some significance for ensu-ring the safety of mother and child.

Objective To identify the candidates targeting capsid formation of HBV by screening a FDA approved drug library. Methods SRluc-HBc6 cells, which indicates the formation of HBc dimers by the split luciferase complementation (SLC), were used as the 1st round screening model. Compounds identified by the 1st round screening were tested for their ability to inhibit the formation of capsid by using particle gel assay. Southern blotting was employed to detect the anti-HBV activity of these compounds on the replication of HBV DNA. Results According to the Rluc activities of SRluc-HBc6 cells, 5 candidates were screened out of 1 434 drugs in the first round screening. They are chlorambucil, cladribine, methylene blue, sorafenib, and regorafenib. Further tests showed that chlorambucil inhibited the replication of HBV DNA in HepAD38 cells by reducing the formation of HBV core dimers and capsids. Conclusion Chlorambucil inhibit HBV DNA replication in vitro by reducing HBV core dimers and the formation of capsid.

In view of the accident of main transformer being broken due to tower at incoming lines of Tunlan substation caused by lightning strike, the problems of lightning protection measures of the incoming lines were analyzed and researched. The research results show that the lightning protection of the incoming lines has problems such as excessive grounding resistance of the tower, too high lines insulation level, and mismatching between action value of arrester and lines insulation level. In view of the existing problems and hidden dangers, the following modification measures were proposed: optimize impulse grounding of the tower at incoming lines by using dendritic radioactive grounding body; use adjustable overvoltage protection gap to match lines arresters on the terminal tower, so as to form refined comprehensive protection of the incoming lines; install gap-free zinc oxide arrester on the terminal tower at incoming lines. The ATP-EMTP simulation results show that the combined effects of the three modification measures can effectively reduce amplitude and steepness of lightning intruding wave and ensure safe operation of the mine power grid.

Superplastic tensile behavior and deformation mechanism of TC18 titanium alloy were investigated by high temperature tensile test at 720-950℃ with initial strain rates of 6.7×10-5s-1-3.3×10-1s-1.The results show that under the optimal superplastic deformation condition (890℃ and 3.3×10-4s-1),the maximum elongation is 470%, the peak stress is 17.93MPa and with uniform grain size.Below the phase transus Tβ,the elongation firstly increases and then decreases.A maximum elongation of 373% is obtained at 830℃ and with initial strain rate of 3.3×10-4s-1 and the peak stress is 31.45MPa.The superplastic deformation mechanism of the TC18 titanium alloy in two-phase region is mainly grain rotation and boundary sliding,and the deformation coordination mechanism is dislocation slipping and climbing; the superplastic deformation mechanism in single phase region is intragranular dislocation motion and the deformation coordination mechanism is dynamic recovery and dynamic recrystallization.