96 results on '"SGANZERLA, ERIK PIETRO"'
Search Results
2. Intraoperative Echo in TBI
- Author
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Giussani, Carlo, primary, Sganzerla, Erik Pietro, additional, Prada, Francesco, additional, and Di Cristofori, Andrea, additional
- Published
- 2020
- Full Text
- View/download PDF
3. Does emergent implantation of a vagal nerve stimulator stop refractory status epilepticus in children?
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Grioni, Daniele, Landi, Andrea, Fiori, Leonardo, and Sganzerla, Erik Pietro
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- 2018
- Full Text
- View/download PDF
4. Effectiveness of Intraventricular Endoscopic Lamina Terminalis Fenestration in Comparison with Standard ETV: Systematic Review of Literature
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Giussani, Carlo, Guida, Lelio, Trezza, Andrea, and Sganzerla, Erik Pietro
- Published
- 2017
- Full Text
- View/download PDF
5. Craniovertebral Junction Pathological Features and Their Management in the Mucopolysaccharidoses
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Sganzerla, Erik Pietro, Giussani, Carlo, Grimaldi, Marco, Parini, Rossella, Ingelmo, Pablo, Trezza, Andrea, Visocchi, Massimiliano, Schramm, Johannes, Editor-in-Chief, Di Rocco, Concezio, Series Editor, and Akalan, Nejat, Series Editor
- Published
- 2014
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6. The Disease of the Italian Poet Giacomo Leopardi (1798–1837): A Case of Juvenile Ankylosing Spondylitis in the 19th Century?
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Sganzerla, Erik Pietro and Riva, Michele Augusto
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- 2017
- Full Text
- View/download PDF
7. Deep brain stimulation for the treatment of cerebellar tremor: 9 June – 061.
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Trezza, Andrea, Pirillo, David, Antonini, Angelo, Sganzerla, Erik Pietro, and Landi, Andrea
- Published
- 2015
8. Vagal nerve stimulation for the treatment of severe epilepsy in children: 08 June – 056.
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Landi, Andrea, Grioni, Daniele, Trezza, Andrea, Pirillo, David, Fiori, Leonardo, Giussani, Carlo, and Sganzerla, Erik Pietro
- Published
- 2015
9. Craniovertebral Junction Pathological Features and Their Management in the Mucopolysaccharidoses
- Author
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Sganzerla, Erik Pietro, primary, Giussani, Carlo, additional, Grimaldi, Marco, additional, Parini, Rossella, additional, Ingelmo, Pablo, additional, Trezza, Andrea, additional, and Visocchi, Massimiliano, additional
- Published
- 2013
- Full Text
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10. Spinal Cord Stimulation for the Treatment of Sensory Symptoms in Advanced Parkinsonʼs Disease
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Landi, Andrea, Trezza, Andrea, Pirillo, David, Vimercati, Alberto, Antonini, Angelo, and Sganzerla, Erik Pietro
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- 2013
- Full Text
- View/download PDF
11. Adverse effects and surgical complications in pediatric patients undergoing vagal nerve stimulation for drug-resistant epilepsy
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Visocchi, M, Mehdorn, HM, Katayama, Y, von Wild, KRH, Trezza, A, Landi, A, Grioni, D, Pirillo, D, Fiori, L, Giussani, C, Sganzerla, E, GIUSSANI, CARLO GIORGIO, SGANZERLA, ERIK PIETRO, Visocchi, M, Mehdorn, HM, Katayama, Y, von Wild, KRH, Trezza, A, Landi, A, Grioni, D, Pirillo, D, Fiori, L, Giussani, C, Sganzerla, E, GIUSSANI, CARLO GIORGIO, and SGANZERLA, ERIK PIETRO
- Abstract
Vagal nerve stimulation (VNS) is an effective treatment for drug-resistant epilepsy that is not suitable for resective surgery, both in adults and in children. Few reports describe the adverse effects and complications of VNS. The aim of our study was to present a series of 33 pediatric patients who underwent VNS for drug-resistant epilepsy and to discuss the adverse effects and complications through a review of the literature. The adverse effects of VNS are usually transient and are dependent on stimulation of the vagus and its efferent fibers; surgical complications of the procedure may be challenging and patients sometimes require further surgery; generally these complications affect VNS efficacy; in addition, hardware complications also have to be taken into account. In our experience and according to the literature, adverse effects and surgical and hardware complications are uncommon and can usually be managed definitely. Careful selection of patients, particularly from a respiratory and cardiac point of view, has to be done before surgery to limit the incidence of some adverse effects.
- Published
- 2017
12. The disease of the Italian poet giacomo leopardi (1798-1837): A case of juvenile ankylosing spondylitis in the 19th century?
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Sganzerla, E, Riva, M, SGANZERLA, ERIK PIETRO, RIVA, MICHELE AUGUSTO, Sganzerla, E, Riva, M, SGANZERLA, ERIK PIETRO, and RIVA, MICHELE AUGUSTO
- Abstract
Some authors sustained that the pessimistic thought of the Italian writer and philosopher Giacomo Leopardi (1798-1837) may be attributed to his unhappy life, characterized by several health problems. His philosophical theories appear as the result of depressive and melancholic state, related to his precarious health conditions, so limiting their intrinsic values. Several authors formulated various hypotheses on the diseases that Leopardi suffered from and postulated different theories on the cause of his early death. This article assumed that Leopardi may have been affected by juvenile ankylosing spondylitis, conditioning spinal deformities, relapsing-remitting uveitis, urinary tract and bowel tract problems, and acute arthritis. Chest deformity, as a complication of juvenile ankylosing spondylitis,may have caused progressive cardiorespiratory failure, worsened by recurrent bronchial and pulmonary complications, until his death caused by acute right ventricular heart failure. The acknowledgment of a physical cause of Leopardi's disease contributes to reevaluate his "cosmic pessimism" as an original expression of his thought, so leading a general revaluation of the figure of one of the most important European thinkers of the 19th century
- Published
- 2017
13. Effectiveness of Intraventricular Endoscopic Lamina Terminalis Fenestration in Comparison with Standard ETV: Systematic Review of Literature
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Giussani, C, Guida, L, Trezza, A, Sganzerla, E, GIUSSANI, CARLO GIORGIO, SGANZERLA, ERIK PIETRO, Giussani, C, Guida, L, Trezza, A, Sganzerla, E, GIUSSANI, CARLO GIORGIO, and SGANZERLA, ERIK PIETRO
- Abstract
Background Endoscopic third ventriculostomy is a consolidated technique for the treatment of hydrocephalus. Despite its effectiveness and feasibility, several technical limitations about its use in certain situations have been described. Lamina terminalis–endoscopic third ventriculostomy (LT-ETV) has been proposed as an alternative technique. Authors systematically reviewed the literature in order to define the effectiveness and limits in comparison with standard ETV. Methods This systematic review followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. It has also been registered with the PROSPERO International Prospective Register of Systematic Reviews (CRD42016041596). MEDLINE, Web of Knowledge, and EMBASE were independently searched. Results Seven studies were found to be eligible. A case of ours was added to the series, totaling 41 patients (mean patient age ± SD was 21.6 ± 20.7 years). Endoscopic findings leading surgeons to perform LT-ETV were abnormal ventricular anatomy (24, 57%), inadequate/insufficient interpeduncular subarachnoid space (11, 26%), a combination of both (5, 12%), and intraoperatory, unsatisfactory third ventricle floor fenestration (2, 5%). Most common pathologies were neurocysticercosis (12, 28.57%), aqueductal stenosis (8, 19%), tuberculous meningitis (4, 9.52%), and medulloblastoma (3, 7.14%). A flexible endoscope was the most used device (36 procedures, 86%), while not determining a statistical relevant diminution of complications in comparison with a rigid endoscope (P = 1.0). An overall success rate of 69% was registered, increasing to 89% if just the first year of follow-up was considered. Conclusions LT-ETV can be considered a successful technical option when standard ETV cannot be performed, although more complex cerebrovascular anatomy is involved. Therefore we suggest that lateral terminalis fenestration is a valid technical option in experienced hands.
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- 2017
14. Experimental in-vivo model of intravascular shunting for neurosurgical bypass
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Riva, M, Beretta, S, Carone, D, Pappada', G, Bruneau, M, Giussani, C, Paterno', G, Versace, A, Ferrarese, C, Sganzerla, E, RIVA, MARTA, CARONE, DAVIDE, GIUSSANI, CARLO GIORGIO, FERRARESE, CARLO, SGANZERLA, ERIK PIETRO, Riva, M, Beretta, S, Carone, D, Pappada', G, Bruneau, M, Giussani, C, Paterno', G, Versace, A, Ferrarese, C, Sganzerla, E, RIVA, MARTA, CARONE, DAVIDE, GIUSSANI, CARLO GIORGIO, FERRARESE, CARLO, and SGANZERLA, ERIK PIETRO
- Abstract
BACKGROUND: Excessively long clamping time and suboptimal position of stitches can influence the anastomosis patency and the clinical outcome in cerebral bypass surgery. Coronary intravascular micro-shunts could represent an innovative solution for neurosurgical bypass, but the hemodynamic properties of these devices should be extensively studied before their translational application. We created an experimental in-vivo model and we analyzed the blood flow and pressure modification induced by the micro-shunt. METHODS: After laparotomy, an intravascular micro-shunt was placed into the aorta of 8 adult rats, simulating a neurosurgical setting in which the shunt is temporary placed inside the receiving cerebral vessel. A fiber-optic pressure sensor was placed in the femoral artery and the blood pressure continuously recorded during the procedure. Using an ultrasound vascular probe, blood flow velocity in aorta was measured at baseline and both proximally and distally to the shunt. RESULTS: After shunt positioning, no significant decrease in blood pressure was observed (mean value 68.57 versus 80.00 mmHg; P=0.48). Distal aortic blood flow, expressed as peak systolic velocity, showed a significant decrease after shunt positioning (mean value 51.88 versus 86.88 cm/sec; P=0.04), with a mean residual blood flow of 63%. Blood flow values recorded immediately upstream to the shunt did not differ from baseline. CONCLUSIONS: This is the first in-vivo experimental study concerning the hemodynamic properties of an intravascular micro-shunt. Our results demonstrate that this device provides a considerable blood out-flow without significant changes in blood pressure, suggesting that specific neurosurgical micro-shunts might be developed.
- Published
- 2017
15. Intracerebral Hemorrhage In Icu: Better Than Expected!
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MARZORATI, CHIARA, SPINA, STEFANO, SCARAVILLI, VITTORIO, RIVA, MATTEO, GIUSSANI, CARLO GIORGIO, SGANZERLA, ERIK PIETRO, CITERIO, GIUSEPPE, Vargiolu, A, Marzorati, C, Spina, S, Scaravilli, V, Vargiolu, A, Riva, M, Giussani, C, Sganzerla, E, and Citerio, G
- Subjects
Intracerebral Hemorrhage - Published
- 2016
16. Intracerebral hemorrhage in ICU: is it worth treating?
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Sivakumar, S, Taccone, F, Desai, K, Lazaridis, C, Skarzynski, M, Sekhon, M, Henderson, W, Griesdale, D, Chapple, L, Deane, A, Williams, L, Strickland, R, Lange, K, Heyland, D, Chapman, M, Rowland, M, Garry, P, Westbrook, J, Corkill, R, Antoniades, C, Pattinson, K, Fatania, G, Strong, A, Myers, R, Jermaine, C, Robertson, C, Rusin, C, Hofmeijer, J, Sondag, L, Tjepkema Cloostermans, M, Beishuizen, A, Bosch, F, van Putten, M, Carteron, L, Patet, C, Solari, D, Oddo, M, Ali, M, Dias, C, Almeida, R, Vaz Ferreira, A, Silva, J, Monteiro, E, Cerejo, A, Rocha, A, Elsayed, A, Abougabal, A, Beshey, B, Alzahaby, K, Pozzebon, S, Ortiz, A, Cristallini, S, Lheureux, O, Brasseur, A, Vincent, J, Creteur, J, Hravnak, M, Yousef, K, Chang, Y, Crago, E, Friedlander, R, Abdelmonem, S, Tahon, S, Helmy, T, Meligy, H, Puig, F, Dunn Siegrist, I, Pugin, J, Gupta, S, Govil, D, Srinivasan, S, Patel, S, N, J, Gupta, A, Tomar, D, Shafi, M, Harne, R, Arora, D, Talwar, N, Mazumdar, S, Papakrivou, E, Makris, D, Manoulakas, E, Tsolaki, B, Karadodas, B, Zakynthinos, E, Garcia, I, Martin, A, Encinares, V, Ibañez, M, Montero, J, Labrador, G, Cangueiro, T, Poulose, V, Koh, J, Kam, J, Yeter, H, Kara, A, Aktepe, O, Topeli, A, Tsolakoglou, I, Intas, G, Stergiannis, P, Kolaros, A, Chalari, E, Athanasiadou, E, Martika, A, Fildisis, G, Faivre, V, Mengelle, C, Favier, B, Payen, D, Poppe, A, Winkler, M, Mudersbach, E, Schreiber, J, Wruck, M, Schwedhelm, E, Kluge, S, Zöllner, C, Tavladaki, T, Spanaki, A, Dimitriou, H, Kondili, E, Choulaki, C, Meleti, E, Kafetzopoulos, D, Georgopoulos, D, Briassoulis, G, la Torre, A, de la Torre Prados, M, Tsvetanova Spasova, T, Nuevo Ortega, P, Rueda Molina, C, Fernández Porcel, A, Camara Sola, E, Salido Díaz, L, García Alcántara, A, Meleti, D, Suberviola, B, Riera, J, Rellan, L, Sanchez, M, Robles, J, Lopez, E, Vicente, R, Miñambres, E, Santibañez, M, Le Guen, M, Moore, J, Mason, N, Windpassinger, M, Plattner, O, Mascha, E, Sessler, D, Research, O, Melia, U, Fontanet, J, van den Berg, J, Struys, M, Vereecke, H, Jensen, E, Rood, P, van de Schoor, F, van Tertholen, K, Pickkers, P, van den Boogaard, M, Beardow, Z, Redhead, H, Paramasivam, K, Numan, T, Kamper, A, Peelen, L, Zeman, P, Slooter, A, van Ewijk, C, Jacobs, G, Girbes, A, Myatra, S, Harish, M, Prabu, N, Siddiqui, S, Kulkarni, A, Divatia, J, Murbach, L, Leite, M, Osaku, E, Costa, C, Pelenz, M, Neitzke, N, Moraes, M, Jaskowiak, J, Silva, M, Zaponi, R, Abentroth, L, Ogasawara, S, Jorge, A, Duarte, P, Hernández Sánchez, N, Sánchez Hurtado, L, García Guillen, F, Ñamendys Silva, S, Maghsoudi, B, Emami, M, Khosravi, M, Zand, F, Tabatabaie, H, Masjedi, M, Sabetiyan, G, Mokri, A, Troubleyn, J, Diltoer, M, Jacobs, R, Nguyen, D, De Waele, E, De Regt, J, Honoré, P, Van Gorp, V, Spapen, H, Contreras, R, Toapanta, N, Moreno, G, Sabater, J, Torrado, H, Gonzalez, M, Marin, M, Farigola, E, Gonzalez, A, Fernandez, J, Vera, A, Gisbert, X, Juliá, C, Uya, J, Corral, L, Elias Jones, I, Gemmell, L, Mackay, A, Randall, D, Adwaney, A, Blunden, M, Prowle, J, Kirwan, C, Thomas, N, Owen, H, Darwin, L, Conway, D, Atkinson, D, Sharman, M, Barbanti, C, Amour, J, Gaudard, P, Rozec, B, Mauriat, P, M'Rini, M, Leger, P, Cambonie, G, Liet, J, Girard, C, Laroche, S, Damas, P, Assaf, Z, Loron, G, Lecourt, L, Pouard, P, Kim, S, Na, S, Kim, J, Oh, S, Jung, C, Yoo, S, Min, S, Chung, E, Lee, H, Lee, N, Lee, K, Suh, K, Ryu, H, Marshall, D, Goodson, R, Salciccioli, J, Shalhoub, J, Potter, E, Kirk Bayley, J, Karanjia, N, Forni, L, Creagh Brown, B, Bossy, M, Nyman, M, Tailor, A, D'Antini, D, Spadaro, S, Valentino, F, Sollitto, F, Cinnella, G, Mirabella, L, Calvo, F, Bejarano, N, Padilla, D, Baladron, V, Villajero, P, Villazala, R, Redondo, J, Yuste, A, Liu, J, Shen, F, Teboul, J, Anguel, N, Beurton, A, Bezaz, N, Richard, C, Monnet, X, Fossali, T, Colombo, R, Ottolina, D, Rossetti, M, Mazzucco, C, Marchi, A, Porta, A, Catena, E, Tollisen, K, Andersen, G, Heyerdahl, F, Jacobsen, D, de Waard, M, van IJzendoorn, M, Buter, H, Kingma, W, Navis, G, Boerma, E, Rulisek, J, Balik, M, Zacharov, S, Kim, H, Jeon, S, Namgung, H, Lee, E, Cho, Y, Lee, Y, Huang, A, Cioccari, L, Luethi, N, Mårtensson, J, Bellomo, R, Forsberg, M, Edman, G, Höjer, J, Forsberg, S, Freile, M, Hidalgo, F, Molina, J, Lecumberri, R, Rosselló, A, Travieso, P, Leon, G, Sanchez, J, Frias, L, Rosello, D, Verdejo, J, Serrano, J, Winterwerp, D, van Galen, T, Vazin, A, Karimzade, I, Zand, A, Ozen, E, Ekemen, S, Akcan, A, Sen, E, Yelken, B, Kureshi, N, Fenerty, L, Thibault Halman, G, Erdogan, M, Walling, S, Green, R, Clarke, D, Briassoulis, P, Kalimeris, K, Ntzouvani, A, Nomikos, T, Papaparaskeva, K, Politi, E, Kostopanagiotou, G, Crewdson, K, Rehn, M, Weaver, A, Brohi, K, Lockey, D, Wright, S, Thomas, K, Baker, C, Mansfield, L, Stafford, V, Wade, C, Watson, G, Bryant, A, Chadwick, T, Shen, J, Wilkinson, J, Furneval, J, Henderson, A, Hugill, K, Howard, P, Roy, A, Bonner, S, Baudouin, S, Ramírez, C, Escalada, S, Viera, M, Santana, M, Balcázar, L, Monroy, N, Campelo, F, Vázquez, C, Santana, P, Santana, S, Quintard, H, Bouzat, P, Wollersheim, T, Malleike, J, Haas, K, Carbon, N, Schneider, J, Birchmeier, C, Fielitz, J, Spuler, S, Weber Carstens, S, Enseñat, L, Pérez Madrigal, A, Saludes, P, Proença, L, Gruartmoner, G, Espinal, C, Mesquida, J, Huber, W, Eckmann, M, Elkmann, F, Gruber, A, Lahmer, T, Mayr, U, Herner, A, Schellnegger, R, Schmid, R, Ayoub, W, Samy, W, Esmat, A, Battah, A, Mukhtar, S, Mongkolpun, W, Cortés, D, Cordeiro, C, Funcke, S, Groesdonk, H, Saugel, B, Wagenpfeil, G, Wagenpfeil, S, Reuter, D, Fernandez, M, Fernandez, R, Magret, M, González Castro, A, Bouza, M, García, C, Balerdi, B, Mas, A, Arauzo, V, Añón, J, Ruiz, F, Ferreres, J, Tomás, R, Alabert, M, Tizón, A, Altaba, S, Llamas, N, Goligher, E, Fan, E, Herridge, M, Vorona, S, Sklar, M, Dres, M, Rittayamai, N, Lanys, A, Urrea, C, Tomlinson, G, Reid, W, Rubenfeld, G, Kavanagh, B, Brochard, L, Ferguson, N, Neto, A, de Abreu, M, Pelosi, P, Schultz, M, Guérin, C, Papazian, L, Reignier, J, Ayzac, L, Loundou, A, Forel, J, Rolland Debord, C, Bureau, C, Poitou, T, Clavel, M, Perbet, S, Terzi, N, Kouatchet, A, Similowski, T, Demoule, A, Hunfeld, N, Trogrlic, Z, Ladage, S, Osse, R, Koch, B, Rietdijk, W, Devlin, J, van der Jagt, M, Picetti, E, Ceccarelli, P, Mensi, F, Malchiodi, L, Risolo, S, Rossi, I, Antonini, M, Servadei, F, Caspani, M, Roquilly, A, Lasocki, S, Seguin, P, Geeraerts, T, Perrigault, P, Dahyot Fizelier, C, Paugam Burtz, C, Cook, F, Cinotti, R, Dit Latte, D, Mahe, P, Fortuit, C, Feuillet, F, Asehnoune, K, Marzorati, C, Spina, S, Scaravilli, V, Vargiolu, A, Riva, M, Barbadillo, S, de Molina, F, Álvarez Lerma, F, Rodríguez, A, Zakharkina, T, Martin Loeches, I, Matamoros, S, Povoa, P, Torres, A, Kastelijn, J, Hofstra, J, de Jong, M, Sterk, P, Artigas, A, Bos, L, Moreau, A, Salluh, J, Rodriguez, A, Nseir, S, de Jong, E, van Oers, J, Nijsten, M, de Lange, D, Bonvicini, D, Labate, D, Benacchio, L, Olivieri, A, Pizzirani, E, Lopez Delgado, J, Gonzalez Romero, M, Fuentes Mila, V, Berbel Franco, D, Romera Peregrina, I, Martinez Pascual, A, Perez Sanchez, J, Abellan Lencina, R, Ávila Espinoza, R, Moreno Gonzalez, G, Sbraga, F, Griffiths, S, Grocott, M, Doyle, J, Wilkerson, P, Soon, Y, Huddart, S, Dickinson, M, Riga, A, Zuleika, A, Miyamoto, K, Kawazoe, Y, Morimoto, T, Yamamoto, T, Fuke, A, Hashimoto, A, Koami, H, Beppu, S, Katayama, Y, Ito, M, Ohta, Y, Yamamura, H, Rygård, S, Holst, L, Wetterslev, J, Johansson, P, Perner, A, Soliman, I, van Dijk, D, van Delden, J, Cremer, O, Mcwilliams, D, Snelson, C, Neves, A, Loudet, C, Busico, M, Vazquez, D, Villalba, D, Veronesi, M, Lischinsky, A, López, F, Mori, L, Plotnikow, G, Díaz, A, Giannasi, S, Hernandez, R, Krzisnik, L, Cecotti, C, Viola, L, Lopez, R, Sottile, J, Benavent, G, Estenssoro, E, Chen, C, Lai, C, Cheng, K, Chou, W, Chan, K, Roeker, L, Horkan, C, Gibbons, F, Christopher, K, Weijs, P, Mogensen, K, Rawn, J, Robinson, M, Tang, Z, Qiu, C, Ouyang, B, Cai, C, Guan, X, Regueira, T, Cea, L, Carlos, S, Elisa, B, Puebla, C, Vargas, A, Poulsen, M, Thomsen, L, Kjærgaard, S, Rees, S, Karbing, D, Frank, S, Müller, M, Skrypnikov, V, Pickerodt, P, Falk, R, Mahlau, A, Lee, A, Inglis, R, Morgan, R, Barker, G, Kamata, K, Abe, T, Saitoh, D, Tokuda, Y, Butler, M, Hwa, H, Gil, L, Vaquero, R, Rodriguez Ruiz, E, Lago, A, Allut, J, Gestal, A, Thomas Rüddel, D, Schwarzkopf, D, Fleischmann, C, Reinhart, K, Suwanpasu, S, Sattayasomboon, Y, Filho, N, Oliveira, J, Ballalai, C, De Lucia, C, Araponga, G, Veiga, L, Silva, C, Garrido, M, Ramos, B, Ricaldi, E, Gomes, S, Wright, C, Docking, R, Doherty, P, Black, E, Stenhouse, P, Plummer, M, Finnis, M, Phillips, L, Kar, P, Bihari, S, Biradar, V, Moodie, S, Horowitz, M, Shaw, J, Yatabe, T, Inoue, S, Sakaguchi, M, Egi, M, Abdelhamid, Y, Hokka, M, Mizobuchi, S, Giersch, E, Summers, M, Hatzinikolas, S, Heller, S, Jones, K, Schweizer, R, Jacquet Lagreze, M, Portran, P, Junot, S, Allaouchiche, B, Fellahi, J, Guerci, P, Ergin, B, Kapucu, A, Ince, C, Crisman, M, Shinotsuka, C, Fagnoul, D, Orbegozo, D, Preiser, J, Thooft, A, Brimioulle, S, Iwasaka, H, Tahara, S, Nagamine, M, Ichigatani, A, Cabrera, A, Zepeda, E, Granillo, J, Sánchez, J, Montoya, A, Montenegro, A, Blanco, G, Robles, C, Drolz, A, Horvatits, T, Roedl, K, Rutter, K, Funk, G, Schneeweiss, B, Fuhrmann, V, Sabetian, G, Pooresmaeel, F, Ghaffaripour, S, Farbod, A, Tabei, H, Taheri, L, Anandanadesan, R, Metaxa, V, Teixeira, C, Pereira, S, Hernández Marrero, P, Carvalho, A, Beckmann, M, Hartog, C, Raadts, A, Robertsen, A, Førde, R, Skaga, N, Helseth, E, Honeybul, S, Ho, K, Lopez, P, Ortega, P, Sola, E, Spasova, T, Kopecky, O, Rusinova, K, Waldauf, P, Cepeplikova, Z, Domínguez, J, Almudevar, P, Carmona, S, Muñoz, J, Castañeda, D, Abellán, A, Villamizar, P, Ramos, J, Pérez, L, Lucendo, A, Ejarque, M, Estella, A, Camps, V, Martín, M, Masnou, N, Barbosa, S, Varela, A, Palma, I, Cristina, L, Nunes, E, Pereira, I, Campello, G, Granja, C, Pande, R, Pandey, M, Varghese, S, Chanu, M, Van Dam, M, Ter Braak, E, Gracia, M, Viciana, R, Recuerda, M, Fontaiña, L, Tharmalingam, B, Kovari, F, Rose, L, Mcginlay, M, Amin, R, Burns, K, Connolly, B, Hart, N, Jouvet, P, Katz, S, Leasa, D, Mawdsley, C, Mcauley, D, Blackwood, B, Denham, S, Worrall, R, Arshad, M, Isherwood, P, Khadjibaev, A, Sabirov, D, Rosstalnaya, A, Parpibaev, F, Sharipova, V, Guzman, C, Cha, Y, Lee, S, Tyagi, N, Rajput, R, Taneja, S, Singh, V, Sharma, S, Mittal, S, Rao, B, Ayachi, J, Fraj, N, Romdhani, S, Khedher, A, Meddeb, K, Sma, N, Azouzi, A, Bouneb, R, Chouchene, I, El Ghardallou, M, Boussarsar, M, Jennings, R, Walter, E, Ribeiro, J, Moniz, I, Marçal, R, Santos, A, Candeias, C, E. 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Nirmalan, M, Crippa, I, Cavicchi, F, Chaari, A, Hakim, K, Hassanein, H, Etman, M, El Bahr, M, Bousselmi, K, Khalil, E, Kauts, V, Casey, W, Imahase, H, Sakamoto, Y, Yamada, K, Miike, T, Nagashima, F, Iwamura, T, Boscolo, A, Lucchetta, V, Piasentini, E, Bertini, D, Manesso, L, Spiezia, L, Simioni, P, Ori, C, Souza, R, Martins, A, Liberatore, A, Kang, Y, Nakamae, M, Koh, I, Hanslin, K, Wilske, F, Skorup, P, Sjölin, J, Lipcsey, M, Long, W, Zhen, C, Vakalos, A, Avramidis, V, Wu, S, Shyu, L, Li, C, Yu, C, Chen, H, Wang, C, Lin, K, Aray, Z, Gómez, C, Tejero, A, Monge, D, Losada, V, Tarancón, C, Cortés, S, Gutiérrez, A, Álvarez, T, Rouze, A, Jaffal, K, Six, S, Stolz, K, Cattoen, V, Arnal, J, Saoli, M, Novotni, D, Garnero, A, Becher, T, Buchholz, V, Schädler, D, Frerichs, I, Weiler, N, Eronia, N, Mauri, T, Gatti, S, Maffezzini, E, Bronco, A, Alban, L, Sasso, T, Marenghi, C, Grasselli, G, Pesenti, A, Bellani, G, Al Fares, A, Del Sorbo, L, Anwar, S, Facchin, F, Azad, S, Zamel, R, Cypel, M, Keshavjee, S, Durlinger, E, Spoelstra de Man, A, de Grooth, H, Straaten, H, Alfaro, M, Parrilla, F, Meli, A, Pellegrini, M, Rodriguez, N, Goyeneche, J, Morán, I, Aguirre, H, Mancebo, J, Heines, S, Strauch, U, Bergmans, D, Blankman, P, Shono, A, Hasan, D, Gommers, D, Chung, W, Jung, Y, Park, J, Sheen, S, Park, K, Worral, R, Larraza, S, Dey, N, Brohus, J, Winding, R, Volta, C, Ampatzidou, F, Vlachou, A, Kehagioglou, G, Karaiskos, T, Madesis, A, Mauromanolis, C, Michail, N, Drossos, G, Saraj, N, Rijkenberg, S, Feijen, H, Endeman, H, Donnelly, A, Morgan, E, Garrard, H, Buckley, H, Russell, L, Haase, N, Goh, C, Mouyis, K, Woodward, C, Halliday, J, Encina, G, Ros, J, Lagunes, L, Tabernero, J, Rello, J, Morente Constantin, E, Rivera Ginés, B, Colmenero Ruiz, M, Sanz, J, Simon, I, Valbuena, B, Pais, M, Ramalingam, S, Díaz, C, Fox, L, Santafe, M, Barba, P, García, M, Leal, S, Veganzones, J, Martínez, N, Moors, I, Mokart, D, Pène, F, Lambert, J, Mayaux, J, Vincent, F, Nyunga, M, Bruneel, F, Laisne, L, Rabbat, A, Lebert, C, Perez, P, Chaize, M, Renault, A, Meert, A, Hamidfar, R, Jourdain, M, Darmon, M, Schlemmer, B, Chevret, S, Lemiale, V, Azoulay, E, Benoit, D, Martins Branco, D, Sousa, M, Marum, S, Bouw, M, Galstyan, G, Makarova, P, Parovichnikova, E, Kuzmina, L, Troitskaya, V, Drize, N, Gemdzhian, E, Savchenko, V, Chao, H, Kılıc, E, Demiriz, B, Uygur, M, Sürücü, M, Cınar, K, Yıldırım, A, Kiss, K, Köves, B, Csernus, V, Molnár, Z, Ntantana, A, Matamis, D, Savvidou, S, Giannakou, M, Gouva, M, Nakos, G, Koulouras, V, Gaffney, S, Judge, C, Drew, T, Misran, H, Munshi, R, Mcgovern, L, Coyle, M, Dunne, L, Deasy, E, Lavin, P, Fahy, A, Darcy, D, Donnelly, M, Ismail, N, Hall, T, Wykes, K, Jack, J, Ngu, W, Morgan, P, Ruiz Ramos, J, Ramirez, P, Gordon, M, Villarreal, E, Frasquet, J, Poveda Andrés, J, Castellanos, A, Ijssennagger, C, Ten Hoorn, S, van Wijk, A, van den Broek, J, Tuinman, P, Elmenshawy, A, Hammond, B, Gibbon, G, Belcham, T, Burton, K, Taniguchi, L, Ramos, F, Momma, A, Martins Filho, A, Bartocci, J, Lopes, M, Sad, M, Rodrigues, C, Pires, E, Barreto, J, Duarte, S, Taba, S, Miglioranza, D, Gund, D, Lordani, C, Capuzzo, M, Corte, F, Terranova, S, Scaramuzzo, G, Fogagnolo, A, Bertacchini, S, Bellonzi, A, Ragazzi, R, Cruz, C, Nunes, A, Pereira, F, Aragão, I, Cardoso, A, Santos, C, Malheiro, M, Castro, H, Cardoso, T, Paratz, J, Kenardy, J, Comans, T, Coyer, F, Thomas, P, Boots, R, Pereira, N, Vilas Boas, A, Gomes, E, Torres, J, Carvalho, D, Molinos, E, Vales, C, Araújo, R, Karnatovskaia, L, Philbrick, K, Ognjen, G, Clark, M, Montero, R, Varas, J, Sánchez Elvira, L, Delgado, C, Díaz, P, Ruiz, B, Guerrero, A, Galache, J, Jiménez, R, Rebollo, S, Alejandro, O, Fernández, A, Moreno, S, Herrera, L, Ojados, A, Galindo, M, Murcia, J, Contreras, M, Sánchez Argente, S, Bonilla, Y, Rodríguez, M, Allegue, J, Cakin, Ö, Parlak, H, Kirca, H, Mutlu, F, Aydınlı, B, Cengiz, M, Ramazanoglu, A, Jung, E, Domenech, J, Montalvo, A, Chornet, T, Martinez, P, Ribas, M, Costa, R, Ortega, A, Forbes, C, Prescott, H, Lal, A, Khan, F, Dela Pena, E, Dizon, J, Wong, C, Garach, M, Romero, O, Puerta, R, Diaz, F, Bailon, A, Pinel, A, Maldonado, L, Kalaiselvan, M, Kumar, R, Renuka, M, De Rosa, S, Ferrari, F, Checcacci, S, Rigobello, A, Joannidis, M, Politi, F, Pellizzari, A, Bonato, R, Fernandez Carmona, A, Macias Guarasa, I, Gutierrez Rodriguez, R, Martinez Lopez, P, Diaz Castellanos, M, Arias Diaz, M, Aguilar Alonso, E, Nikandish, R, Artemenko, V, Budnyuk, A, Bassi, G, Senussi, T, Idone, F, Xiol, E, Travierso, C, Chiurazzi, C, Motos, A, Amaro, R, Hua, Y, Fernández Barat, L, Ranzani, O, Bobi, Q, Rigol, M, Youn, A, Hwang, J, Ossorio, M, Figueira, H, Oliveira, R, Mota, A, Kamp, O, Cruciger, O, Aach, M, Kaczmarek, C, Waydhas, C, Schildhauer, T, Hamsen, U, Camprubí Rimblas, M, Chimenti, L, Guillamat Prats, R, Lebouvier, T, Bringué, J, Tijero, J, Gómez, M, Blanch, L, Tagliabue, G, Ji, M, Jagers, J, Easton, P, Hong, J, Shin, M, Park, M, Pomprapa, A, Hofferberth, M, Russ, M, Braun, W, Walter, M, Francis, R, Lachmann, B, Leonhardt, S, Landaverde López, A, Canedo Castillo, N, Esquivel Chávez, A, Arvizu Tachiquín, P, Baltazar Torres, J, Cardoso, V, Krystopchuk, A, Castro, S, Melão, L, Firmino, S, Marreiros, A, Almaziad, S, Kubbara, A, Barnett, W, Nakity, R, Alamoudi, W, Altook, R, Tarazi, T, Fida, M, Safi, F, Assaly, R, Santini, A, Milesi, M, Maraffi, T, Pugni, P, Cavenago, M, Gattinoni, L, Protti, A, Perchiazzi, G, Borges, J, Bayat, S, Porra, L, Broche, L, Hedenstierna, G, Larsson, A, Roneus, A, Segelsjö, M, Vestito, M, Gremo, E, Nyberg, A, Castegren, M, Pikwer, A, Yoshida, T, Engelberts, D, Otulakowski, G, Katira, B, Post, M, Amato, M, Koch, N, Hoellthaler, J, Mair, S, Phillip, V, Beitz, A, Baladrón, V, Villarejo, P, Steenstra, R, Banierink, H, Hof, J, Hoekstra, M, Sterz, F, Horvatits, K, Herkner, H, Kott, M, Zitta, K, Brandt, B, Schildhauer, C, Elke, G, Hummitzsch, L, Albrecht, M, González, L, Alonso, D, Sánchez, R, Lucas, J, Ferlitsch, A, Fauler, G, Trauner, M, Pischke, S, Fischer, L, Thaiss, F, Koch, M, Bangert, K, Lohse, A, Nashan, B, Sterneck, M, Faenza, S, Siniscalchi, A, Pierucci, E, Mancini, E, Ricci, D, Gemelli, C, Cuoghi, A, Magnani, S, Atti, M, Sotos, F, Cánovas, J, López, A, Burruezo, A, Torres, D, Herrera Gutierrez, M, Barrueco Francioni, J, Arias Verdú, D, Lozano Saez, R, Quesada Garcia, G, Seller Pérez, G, Figueiredo, A, Anzola, Y, Pereira, R, Bento, L, Lai, M, Deiana, M, Seller Perez, G, Vardas, K, Ilia, S, Sertedaki, A, Charmadari, E, Stratakis, C, Briassouli, E, Goukos, D, Psarra, K, Botoula, E, Tsagarakis, S, Mageira, E, Routsi, C, Nanas, S, Campello, E, Radu, C, Su, H, Lam, Y, Willis, K, Pullar, V, Hubner, R, Tsang, J, de Guadiana Romualdo, L, Rebollo Acebes, S, Esteban Torrella, P, Jiménez Sánchez, R, Jiménez Santos, E, Ortín Freire, A, Hernando Holgado, A, Albaladejo Otón, M, Coelho, L, Rabello, L, Póvoa, P, Varis, E, Poukkanen, M, Jacob, S, Takala, J, Wilkman, E, Lundberg, O, Bergenzaun, L, Rydén, J, Rosenqvist, M, Melander, O, Chew, M, Kishihara, Y, Yasuda, H, Jimenez, R, Torrella, P, Fernandez, A, Sanchez, S, Ortin, A, Prats, R, Aguilera, E, Marti, D, Fernandez, L, Ferrer, M, Lanziotti, V, Pulcheri, L, Ribeiro, M, Barbosa, A, E. Silva, J, Soares, M, Marqués, M, Moreno, A, Pizarraya, A, Smani, Y, Connell, M, Zhang, L, Parker, R, Banerjee, I, Clermont, G, Norberg, E, Oras, J, Cuisinier, A, Maufrais, C, Payen, J, Nottin, S, Walther, G, Arib, S, Bilotta, F, Badenes, R, Rubulotta, F, Mirek, S, Monfort, B, Stazi, E, Roig, A, Magnoni, S, Marando, M, Pifferi, S, Conte, V, Ortolano, F, Carbonara, M, Bertani, G, Scola, E, Cadioli, M, Triulzi, F, Colombo, A, Stocchetti, N, Rotzel, H, Lázaro, A, Prada, D, Guimillo, M, Piqueras, C, Guia, J, Simon, M, Arizmendi, A, Carratalá, A, El Maraghi, S, Yehia, A, Bakry, M, Shoman, A, Backes, F, Bianchin, M, Vieira, S, de Souza, A, Backes, A, Klein, C, Arunkumar, A, Lozano, A, Gallaher, C, Cattlin, S, Gordon, S, Picard, J, Fontana, V, Bond, O, Nobile, L, Mrozek, S, Delamarre, L, Capilla, F, Al Saati, T, Fourcade, O, Dominguez Berrot, A, Gonzalez Vaquero, M, Vallejo Pascual, M, Gupta, D, Ivory, B, Chopra, M, Mccarthy, J, Felderhof, C, Macneil, C, Maggiorini, M, Duska, F, Fumis, R, Junior, J, Amarante, G, Skorko, A, Sanders, S, Aron, J, Kroll, R, Redfearn, C, Krishnan, P, Khalil, J, Kongpolprom, N, Gulia, V, Lourenço, E, Duro, C, Baptista, G, Alves, A, Arminda, B, Rodrigues, M, Hayward, J, Baldwin, F, Gray, R, Katinakis, P, Stijf, M, Ten Kleij, M, Jansen Frederiks, M, Broek, R, de Bruijne, M, Spronk, P, Sinha, K, Luney, M, Palmer, K, Keating, L, Abu Habsa, M, Bahl, R, Baskaralingam, N, Ahmad, A, Kanapeckaite, L, Bhatti, P, Glace, S, Jeyabraba, S, Lewis, H, Kostopoulos, A, Raja, M, West, A, Ely, A, Turkoglu, L, Zolfaghari, P, Baptista, J, Marques, M, Martins, P, Pimentel, J, Su, Y, Villacres, S, Stone, M, Parsikia, A, Medar, S, O'Dea, K, Porter, J, Tirlapur, N, Jonathan, J, Singh, S, Takata, M, Mcwhirter, E, Lyon, R, Hariz, M, Azmi, E, Alkhan, J, Movsisyan, V, Petrikov, S, Marutyan, Z, Aliev, I, Evdokimov, A, Antonucci, E, Merz, T, Hartmann, C, Calzia, E, Radermacher, P, Nußbaum, B, Huber Lang, M, Gröger, M, Svoren Jabalera, E, Davenport, E, Humburg, P, Knight, J, Hinds, C, Jun, I, Kim, W, Besch, G, Perrotti, A, Puyraveau, M, Baltres, M, Samain, E, Chocron, S, Pili Floury, S, Plata Menchaca, E, Sabater Riera, J, Estruch, M, Boza, E, Toscana Fernández, J, Bruguera Pellicer, E, Ordoñez Llanos, J, Pérez Fernández, X, Cavaleiro, P, Tralhão, A, Arrigo, M, Lopes, J, Lebrun, M, Cholley, B, Perezvela, J, Marinmateos, H, Rivera, J, Llorente, M, De Marcos, B, Fernandez, F, Laborda, C, Zamora, D, Delgado, J, Imperiali, C, Dastis, M, Górka, J, Górka, K, Iwaniec, T, Frołow, M, Polok, K, Fronczek, J, Kózka, M, Musiał, J, Szczeklik, W, Sileli, M, Moursia, C, Maleoglou, H, Leleki, K, Uz, Z, Ince, Y, Papatella, R, Bulent, E, De Mol, B, Vicka, V, Gineityte, D, Ringaitiene, D, Norkiene, I, Sipylaite, J, Möller, C, Thomas Rueddel, D, Vlasakov, V, Rochwerg, B, Theurer, P, Al Sibai, J, Camblor, P, Fernandez, P, Gala, J, Guisasola, J, Tamura, T, Miyajima, I, Yamashita, K, Yokoyama, M, Dalampini, E, Nastou, M, Baddour, A, Ignatiadis, A, Asteri, T, Hathorn, K, Purtle, S, Viana, M, Tonietto, T, Gross, L, Costa, V, Tavares, A, Lisboa, B, Moraes, R, Viana, L, Azevedo, M, Ceniccola, G, Pequeno, R, Holanda, T, Mendonça, V, Araújo, W, Carvalho, L, Segaran, E, Vickers, L, Brinchmann, K, Wignall, I, De Brito Ashurst, I, Del Olmo, R, Vaquerizo, C, Carreño, R, Gálvez, V, Kaminsky, G, Nieto, B, Fuentes, M, De la Torre, M, Torres, E, Alonso, A, Velayos, C, Saldaña, T, Escribá, A, Grip, J, Kölegård, R, Sundblad, P, Rooyackers, O, Naser, B, Jaziri, F, Jazia, A, Barghouth, M, Hentati, O, Skouri, W, El Euch, M, Mahfoudhi, M, Turki, S, Abdelghni, K, Abdallah, B, Maha, B, Lorente, M, Włudarczyk, A, Hałek, A, Bargouth, M, Bennasr, M, Abdelghani, K, Abdallah, T, Geenen, I, Parienti, J, Shum, H, King, H, Yan, W, Londoño, J, Cardenas, C, Pedrosa, M, Gubianas, C, Bertolin, C, Batllori, N, Sirvent, J, Mukhopadhyay, A, Chan, H, Kowitlawakul, Y, Remani, D, Leong, C, Henry, C, Puthucheary, Z, Mendsaikhan, N, Begzjav, T, Lundeg, G, Dünser, M, Welsh, S, Guerra, E, Zerpa, M, Zechner, F, Berdaguer, F, Risso Vazquez, A, Masevicius, F, Greaney, D, Magee, A, Fitzpatrick, G, Lugo Cob, R, Tejeda Huezo, B, Cano Oviedo, A, Aydogan, M, Togal, T, Taha, A, Chai, H, Kam, C, Razali, S, Sivasamy, V, Kuan, L, Morales, M, Pires, T, and Azevedo, L
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intracerebral haemorrhage in intensive care - Published
- 2016
17. Vagal Nerve Stimulation in the Treatment of Drug-Resistant Epileptic Encephalopathies in Inborn Errors of Metabolism
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Grioni, Daniele, Landi, Andrea, Gasperini, Serena, Trezza, Andrea, Fiori, Leonardo, Rigoldi, Miriam, Parini, Rossella, and Sganzerla, Erik Pietro
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drug-resistant epilepsy ,inborn errors of metabolism ,Article ,vagal nerve stimulation - Abstract
Patients affected by inborn errors of metabolism can develop catastrophic epilepsies ineligible for resective surgery. Few reports concerning vagal nerve stimulation in patients with epileptic encephalopathy in the context of metabolic diseases have been published in the literature. Drug-resistant epilepsies in metabolic disease could be a specific target for vagal nerve stimulation, although the efficacy of this technique in these patients still needs to be proved. The authors report our experience in treating refractory epilepsy with vagal nerve stimulation in 2 patients affected by inborn errors of metabolism. The first patient is a 23-year-old patient affected by glutaric aciduria type II, the other one is a 16-month-old child with nonketotic hyperglycinemia. Vagal nerve stimulation reduced seizures up to 50% in the first case and up to 90% in the second one.
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- 2015
18. Intracerebral Hemorrhage In Icu: Better Than Expected!
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Marzorati, C, Spina, S, Scaravilli, V, Vargiolu, A, Riva, M, Giussani, C, Sganzerla, E, Citerio, G, MARZORATI, CHIARA, SPINA, STEFANO, SCARAVILLI, VITTORIO, RIVA, MATTEO, GIUSSANI, CARLO GIORGIO, SGANZERLA, ERIK PIETRO, CITERIO, GIUSEPPE, Marzorati, C, Spina, S, Scaravilli, V, Vargiolu, A, Riva, M, Giussani, C, Sganzerla, E, Citerio, G, MARZORATI, CHIARA, SPINA, STEFANO, SCARAVILLI, VITTORIO, RIVA, MATTEO, GIUSSANI, CARLO GIORGIO, SGANZERLA, ERIK PIETRO, and CITERIO, GIUSEPPE
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- 2016
19. Malattie del Sistema Nervoso
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FERRARESE, CARLO, APPOLLONIO, ILDEBRANDO, CAVALETTI, GUIDO ANGELO, SGANZERLA, ERIK PIETRO, Cortelli, P, Federico, A, Mancardi, GL, Marciani, MG, Meola, G, Nichelli, P, Toscano, A., Ferrarese, C, Appollonio, I, Cavaletti, G, Mancardi, G, Marciani, M, Sganzerla, E, Toscano, A, FERRARESE, CARLO, APPOLLONIO, ILDEBRANDO, CAVALETTI, GUIDO ANGELO, SGANZERLA, ERIK PIETRO, Cortelli, P, Federico, A, Mancardi, GL, Marciani, MG, Meola, G, Nichelli, P, Toscano, A., Ferrarese, C, Appollonio, I, Cavaletti, G, Mancardi, G, Marciani, M, Sganzerla, E, and Toscano, A
- Abstract
La nuova edizione di Core Curriculum Malattie del sistema nervoso nasce sia dall'esigenza di tenere aggiornata una disciplina dinamica, che negli ultimi anni è andata incontro a una profonda evoluzione, legata ai progressi delle neuroscienze di base, delle metodiche di imaging e all'utilizzo di nuovi farmaci e di nuove procedure interventistiche e sia dall'apprezzamento che docenti e studenti hanno avuto per la prima edizione del testo. I capitoli sono stati revisionati alla luce delle recenti acquisizioni mediche: sono state descritte le nuove potenzialità diagnostiche della TAC perfusionale, della RMN, riportate le nuove classificazioni delle cefalee, delle sindromi epilettiche e della sclerosi multipla, con ampia descrizione dei farmaci disponibili, è stato dedicato un capitolo alle urgenze neurologiche e altro ancora, resta confermato il taglio pratico e didattico dell'opera che ben orienta gli studenti di Medicina e Chirurgia nello studio di questa materia.
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- 2016
20. Therapeutic modulation of intracranial collateral flow improves outcome in experimental ischemic stroke
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CARONE, DAVIDE, BERETTA, SIMONE, CUCCIONE, ELISA, RIVA, MATTEO, PADOVANO, GIADA, PRESOTTO, LUCA, GIUSSANI, CARLO GIORGIO, SGANZERLA, ERIK PIETRO, FERRARESE, CARLO, Versace, A, Dell'Era, V, Cai, R, Paternò, G, Pappadà, GB, Carone, D, Beretta, S, Cuccione, E, Versace, A, Riva, M, Padovano, G, Dell'Era, V, Cai, R, Presotto, L, Paternò, G, Pappadà, G, Giussani, C, Sganzerla, E, and Ferrarese, C
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Preclinical stroke model, Focal cerebral ischemia, Intracranial collateral circulation, Collateral therapeutics - Abstract
Objective: intracranial collateral circulation performance is emerging as a strong outcome determinant in both human and experimental ischemic stroke. The aim of this study was to investigate and compare the effects of two putative strategies, which might actively modulate intracranial collateral flow in the setting of acute cerebral ischemia: intravascular volume load using polygeline and cerebro-selective vasodilatation using acetazolamide. Materials and methods: MCA was transiently occluded (90 min) by intraluminal filament in adult male Wistar rats. 10 rats were left untreated; 30 rats were treated after 30 min of ischemia with intravenous administration of either saline solution (n=10), polygeline (n=10) or acetazolamide (n =10). Intracranial collateral flow was studied in terms of perfusion deficit using multi-site laser Doppler monitoring, functional deficit was assessed using a sensory-motor score and infarct volume was calculated on consecutive sections stained with Cresyl violet, performed 24 hours after ischemia induction. Blood pressure, heart and respiratory rate were continuously monitored by a pressure transducer placed in femoral artery. Results: post-ischemic administration of both polygeline and acetazolamide significantly increased intracranial collateral flow in the territory of leptomeningeal branches during MCA occlusion and reduced infarct size as well as functional deficit, compared to untreated and saline-treated rats. No significant effect on blood pressure was observed. Conclusions: therapeutic modulation of intracranial collateral flow is feasible and is associated with a better outcome after transient MCA occlusion in rats. “Collateral therapeutics” may represent an simple tissue-saving strategy in the hyper-acute phase of ischemic stroke prior to recanalization therapy.
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- 2014
21. Intracranial collateral flow defines the boundaries of molecular penumbra in experimental ischemic stroke
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PADOVANO, GIADA, CUCCIONE, ELISA, CARONE, DAVIDE, GIUSSANI, CARLO GIORGIO, SGANZERLA, ERIK PIETRO, FERRARESE, CARLO, Beretta, S, Versace, A, Riva, M, Presotto, L, Rosseau, D, Chaveau, F, Pappadà, G, Dell'Era, V, Cai, R, Paternò, G, Beretta, S, Cuccione, E, Versace, A, Carone, D, Riva, M, Padovano, G, Dell'Era, V, Cai, R, Presotto, L, Rousseau, D, Chaveau, F, Paternò, G, Pappadà, G, Giussani, C, Sganzerla, E, Ferrarese, C, and Rosseau, D
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Stroke ,Penumbra ,Hemodynamic change ,Preclinical stroke model, Focal cerebral ischemia, Intracranial collateral circulation, Molecular penumbra ,Cerebral collateral ,Neuroprotection - Abstract
Introduction. Intracranial collaterals are dynamically recruited after arterial occlusion and are emerging as a strong determinant of tissue outcome in both human and experimental ischemic stroke. The relationship between collateral flow and ischemic penumbra remains largely unexplored in pre-clinical studies. We investigated the relationship between intracranial collateral flow during transient MCA occlusion and the development of molecular penumbra and ischemic infarct after 24 hours. Material and Methods. MCA was transiently occluded (90 minutes) by intraluminal filament in adult male Wistar rats (n=25). Intracranial collateral flow was studied using multi-site laser Doppler with two probes. A first probe (Probe 1) was attached to the skull 1 mm posterior to the Bregma and 5 mm lateral to the midline (lateral probe, corresponding to the ischemic core of MCA territory). A second probe (Probe 2) was attached to the skull 2 mm anterior to the Bregma and 2 mm lateral to the midline (medial probe, corresponding to the borderzone territory between ACA and MCA territory). Cerebral perfusion monitoring was performed continuously during the entire period of anesthesia (approximately 140 minutes). Two hemodynamic parameters were considered for analysis: i) drop in cerebral perfusion in both probes during MCA occlusion following successful filament insertion. ii) biosignal fluctuation analysis in both probes during the pre-ischemic period and during MCA occlusion. Molecular penumbra was defined by topographical mapping and quantitative signal analysis of HSP70 immunohistochemistry. Functional deficit was assessed using a 18-points sensory-motor score and infarct volume was calculated on consecutive sections stained with Cresyl violet, performed 24 hours after ischemia induction. Results. The degree of functional performance of intracranial collaterals in the territory of leptomeningeal branches during MCA occlusion inversely correlated with HSP70 immunoreactive areas in both cortex and striatum, as well as with infarct size and functional deficit, and predicted the amount of intact tissue after MCA occlusion followed by reperfusion. Intracranial collateral flow is associated with reduced areas of both molecular penumbra and ischemic core and increased areas of intact tissue in rats subjected to MCA occlusion followed by reperfusion. Conclusions. The study has two main findings. First, molecular penumbra showed an irregular patchy topography, whose extent directly correlated with the extent of ischemic core. Second, good collateral status provides complete protection from ischemic injury, without increasing the amount of penumbral tissue, if reperfusion is achieved; conversely, poor collateral status is associated with a greater extent of both ischemic core and molecular penumbra. In conclusion, the degree of cerebral collateral perfusion is inversely correlated with both ischemic core and molecular penumbra during transient proximal MCA occlusion. Our findings prompt the development of collateral therapeutics to provide tissue-saving strategies in the hyper-acute phase of ischemic stroke prior to recanalization therapy.
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- 2014
22. Cerebral collateral flow defines topography and evolution of molecular penumbra in experimental ischemic stroke
- Author
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Beretta, S, Versace, A, Riva, M, Dell’Era, V, Cai, R, MONZA, LAURA, Presotto, L, Rousseau, D, Chauveau, F, CUCCIONE, ELISA, CARONE, DAVIDE, PADOVANO, GIADA, GIUSSANI, CARLO GIORGIO, SGANZERLA, ERIK PIETRO, FERRARESE, CARLO, Beretta, S, Cuccione, E, Versace, A, Carone, D, Riva, M, Padovano, G, Dell’Era, V, Cai, R, Monza, L, Presotto, L, Rousseau, D, Chauveau, F, Giussani, C, Sganzerla, E, and Ferrarese, C
- Subjects
Stroke ,Penumbra ,Hemodynamic change ,Cerebral collateral ,Neuroprotection - Abstract
Introduction. Intracranial collaterals are dynamically recruited after arterial occlusion and are emerging as a strong determinant of tissue outcome in both human and experimental ischemic stroke. The relationship between collateral flow and ischemic penumbra remains largely unexplored in pre-clinical studies. The aim of the present study was to investigate the pattern of collateral flow with regard to penumbral tissue after transient middle cerebral artery (MCA) occlusion in rats. Methods. MCA was transiently occluded (90 minutes) by intraluminal filament in adult male Wistar rats (n=25). Intracranial collateral flow was studied in term of perfusion deficit and biosignal fluctuation analysis using multi-site laser Doppler monitoring. Molecular penumbra was defined by topographical mapping and quantitative signal analysis of Heat Shock Protein 70 kDa (HSP70) immunohistochemistry. Functional deficit and infarct volume were assessed 24 hours after ischemia induction. Results. The results show that functional performance of intracranial collaterals during MCA occlusion inversely correlated with HSP70 immunoreactive areas in both cortex and striatum, as well as with infarct size and functional deficit. Intracranial collateral flow was associated with reduced areas of both molecular penumbra and ischemic core and increased areas of intact tissue in rats subjected to MCA occlusion followed by reperfusion. Conclusion. Our findings prompt the development of collateral therapeutics to provide tissue-saving strategies in the hyper-acute phase of ischemic stroke prior to recanalization therapy.
- Published
- 2014
23. Cerebral collateral flow defines topography and evolution of molecular penumbra in experimental ischemic stroke
- Author
-
Beretta, S, Cuccione, E, Versace, A, Carone, D, Riva, M, Padovano, G, Dell'Era, V, Cai, R, Monza, L, Presotto, L, Rousseau, D, Chauveau, F, Paternò, G, Pappadà, G, Giussani, C, Sganzerla, E, Ferrarese, C, CUCCIONE, ELISA, CARONE, DAVIDE, RIVA, MATTEO, PADOVANO, GIADA, MONZA, LAURA, PRESOTTO, LUCA, GIUSSANI, CARLO GIORGIO, SGANZERLA, ERIK PIETRO, FERRARESE, CARLO, Beretta, S, Cuccione, E, Versace, A, Carone, D, Riva, M, Padovano, G, Dell'Era, V, Cai, R, Monza, L, Presotto, L, Rousseau, D, Chauveau, F, Paternò, G, Pappadà, G, Giussani, C, Sganzerla, E, Ferrarese, C, CUCCIONE, ELISA, CARONE, DAVIDE, RIVA, MATTEO, PADOVANO, GIADA, MONZA, LAURA, PRESOTTO, LUCA, GIUSSANI, CARLO GIORGIO, SGANZERLA, ERIK PIETRO, and FERRARESE, CARLO
- Abstract
Intracranial collaterals are dynamically recruited after arterial occlusion and are emerging as a strong determinant of tissue outcome in both human and experimental ischemic stroke. The relationship between collateral flow and ischemic penumbra remains largely unexplored in pre-clinical studies. The aim of the present study was to investigate the pattern of collateral flow with regard to penumbral tissue after transient middle cerebral artery (MCA) occlusion in rats. MCA was transiently occluded (90. min) by intraluminal filament in adult male Wistar rats (n. =. 25). Intracranial collateral flow was studied in terms of perfusion deficit and biosignal fluctuation analyses using multi-site laser Doppler monitoring. Molecular penumbra was defined by topographical mapping and quantitative signal analysis of Heat Shock Protein 70. kDa (HSP70) immunohistochemistry. Functional deficit and infarct volume were assessed 24. h after ischemia induction. The results show that functional performance of intracranial collaterals during MCA occlusion inversely correlated with HSP70 immunoreactive areas in both the cortex and the striatum, as well as with infarct size and functional deficit. Intracranial collateral flow was associated with reduced areas of both molecular penumbra and ischemic core and increased areas of intact tissue in rats subjected to MCA occlusion followed by reperfusion. Our findings prompt the development of collateral therapeutics to provide tissue-saving strategies in the hyper-acute phase of ischemic stroke prior to recanalization therapy.
- Published
- 2015
24. Efficacy of Vagal Nerve Stimulation in thre treatment of Infantile Spasms: effect of different tuning and stimulation cycles
- Author
-
Landi, A, Grioni, D, Trezza, A, Fiori, L, SGANZERLA, ERIK PIETRO, Landi, A, Grioni, D, Trezza, A, Fiori, L, and Sganzerla, E
- Subjects
VNS, Infantile epilepsy - Published
- 2013
25. Different targets for different patients' profile: how to modulate DBS for Parkinson's disease
- Author
-
Landi, A, Trezza, A, Antonini, A, Vimercati, A, SGANZERLA, ERIK PIETRO, Landi, A, Trezza, A, Antonini, A, Vimercati, A, and Sganzerla, E
- Subjects
DBS, Parkinson, Modulation - Published
- 2013
26. Intracranial collateral flow in experimental ischemic stroke. From hemodynamic monitoring to collateral therapeutics
- Author
-
BERETTA, SIMONE, RIVA, MATTEO, CUCCIONE, ELISA, CARONE, DAVIDE, PADOVANO, GIADA, RODRIGUEZ MENENDEZ, VIRGINIA, SGANZERLA, ERIK PIETRO, FERRARESE, CARLO, Versace, A, Pappadà, GB, Papadakis, M, Beretta, S, Riva, M, Cuccione, E, Carone, D, Padovano, G, Versace, A, RODRIGUEZ MENENDEZ, V, Pappadà, G, Sganzerla, E, Papadakis, M, and Ferrarese, C
- Subjects
Cerebral hemodynamic ,Acute stroke ,Focal cerebral ischemia ,Intracranial collateral flow ,Neuroprotection - Published
- 2012
27. Hemodynamic monitoring of intracranial collateral flow predicts tissue and functional outcome in experimental ischemic stroke
- Author
-
BERETTA, SIMONE, RIVA, MATTEO, CUCCIONE, ELISA, CARONE, DAVIDE, RODRIGUEZ MENENDEZ, VIRGINIA, SGANZERLA, ERIK PIETRO, FERRARESE, CARLO, Pappadà, GB, Papadakis, M, Beretta, S, Riva, M, Pappadà, G, Papadakis, M, Cuccione, E, Carone, D, RODRIGUEZ MENENDEZ, V, Sganzerla, E, and Ferrarese, C
- Subjects
Male ,medicine.medical_specialty ,Hemodynamics ,Collateral Circulation ,Focal cerebral ischemia ,Brain Ischemia ,Cerebral hemodynamic ,Developmental Neuroscience ,Predictive Value of Tests ,medicine.artery ,Internal medicine ,Occlusion ,medicine ,Anterior cerebral artery ,Animals ,Acute stroke ,Common carotid artery ,Cerebral perfusion pressure ,Rats, Wistar ,Stroke ,business.industry ,Blood flow ,Recovery of Function ,medicine.disease ,Neuroprotection ,Rats ,Treatment Outcome ,Neurology ,Anesthesia ,Cerebrovascular Circulation ,Middle cerebral artery ,Cardiology ,business ,Intracranial collateral flow ,Blood Flow Velocity - Abstract
Intracranial collaterals provide residual blood flow to penumbral tissue in acute ischemic stroke and contribute to infarct size variability in humans. In the present study, hemodynamic monitoring of the borderzone territory between the leptomeningeal branches of middle cerebral artery and anterior cerebral artery was compared to lateral middle cerebral artery territory, during common carotid artery occlusion and middle cerebral artery occlusion in rats. The functional performance of intracranial collaterals, shown by perfusion deficit in the territory of leptomeningeal branches either during common carotid artery occlusion or middle cerebral artery occlusion, showed significant variability among animals and consistently predicted infarct size and functional deficit. Our findings indicate that leptomeningeal collateral flow is a strong predictor of stroke severity in rats, similarly to humans. Monitoring of collateral blood flow in experimental stroke is essential for reducing variability in neuroprotection studies and accelerating the development of collateral therapeutics. © 2011 Elsevier Inc.
- Published
- 2012
28. Subtalamic DBS for Parkinson's disease under general anesthesia: clinical results compared with awake surgery
- Author
-
Landi, A, Vimercati, A, Pirillo, D, Antonini, A, Carrara, C, SGANZERLA, ERIK PIETRO, Landi, A, Vimercati, A, Pirillo, D, Antonini, A, Carrara, C, and Sganzerla, E
- Subjects
DBS, General anesthesia, Parkinson - Published
- 2011
29. Neurosurgical complications and their management in mucopolysaccharidosis
- Author
-
GIUSSANI, CARLO GIORGIO, SGANZERLA, ERIK PIETRO, Miori, S, Parini, R, Andria, G, Giussani, C, Miori, S, and Sganzerla, E
- Subjects
CVJ, Hydrocephalus, MPS - Published
- 2010
30. Intracranial Collateral flow defines the boundaries of molecular penumbra in experimental ischemic stroke
- Author
-
Padovano, G, Beretta, S, Cuccione, E, Versace, A, Carone, D, Riva, M, Presotto, L, Rosseau, D, Chaveau, F, Pappadà, G, Giussani, C, Dell'Era, V, Cai, R, Paternò, G, Sganzerla, E, Ferrarese, C, PADOVANO, GIADA, CUCCIONE, ELISA, CARONE, DAVIDE, GIUSSANI, CARLO GIORGIO, SGANZERLA, ERIK PIETRO, FERRARESE, CARLO, Padovano, G, Beretta, S, Cuccione, E, Versace, A, Carone, D, Riva, M, Presotto, L, Rosseau, D, Chaveau, F, Pappadà, G, Giussani, C, Dell'Era, V, Cai, R, Paternò, G, Sganzerla, E, Ferrarese, C, PADOVANO, GIADA, CUCCIONE, ELISA, CARONE, DAVIDE, GIUSSANI, CARLO GIORGIO, SGANZERLA, ERIK PIETRO, and FERRARESE, CARLO
- Abstract
Introduction. Intracranial collaterals are dynamically recruited after arterial occlusion and are emerging as a strong determinant of tissue outcome in both human and experimental ischemic stroke. The relationship between collateral flow and ischemic penumbra remains largely unexplored in pre-clinical studies. We investigated the relationship between intracranial collateral flow during transient MCA occlusion and the development of molecular penumbra and ischemic infarct after 24 hours. Material and Methods. MCA was transiently occluded (90 minutes) by intraluminal filament in adult male Wistar rats (n=25). Intracranial collateral flow was studied using multi-site laser Doppler with two probes. A first probe (Probe 1) was attached to the skull 1 mm posterior to the Bregma and 5 mm lateral to the midline (lateral probe, corresponding to the ischemic core of MCA territory). A second probe (Probe 2) was attached to the skull 2 mm anterior to the Bregma and 2 mm lateral to the midline (medial probe, corresponding to the borderzone territory between ACA and MCA territory). Cerebral perfusion monitoring was performed continuously during the entire period of anesthesia (approximately 140 minutes). Two hemodynamic parameters were considered for analysis: i) drop in cerebral perfusion in both probes during MCA occlusion following successful filament insertion. ii) biosignal fluctuation analysis in both probes during the pre-ischemic period and during MCA occlusion. Molecular penumbra was defined by topographical mapping and quantitative signal analysis of HSP70 immunohistochemistry. Functional deficit was assessed using a 18-points sensory-motor score and infarct volume was calculated on consecutive sections stained with Cresyl violet, performed 24 hours after ischemia induction. Results. The degree of functional performance of intracranial collaterals in the territory of leptomeningeal branches during MCA occlusion inversely correlated with HSP70 immunoreactive areas in bot
- Published
- 2014
31. Therapeutic modulation of intracranial collateral flow improves outcome in experimental ischemic stroke
- Author
-
Carone, D, Beretta, S, Cuccione, E, Versace, A, Riva, M, Padovano, G, Dell'Era, V, Cai, R, Presotto, L, Paternò, G, Pappadà, G, Giussani, C, Sganzerla, E, Ferrarese, C, CARONE, DAVIDE, BERETTA, SIMONE, CUCCIONE, ELISA, RIVA, MATTEO, PADOVANO, GIADA, PRESOTTO, LUCA, GIUSSANI, CARLO GIORGIO, SGANZERLA, ERIK PIETRO, FERRARESE, CARLO, Pappadà, GB, Carone, D, Beretta, S, Cuccione, E, Versace, A, Riva, M, Padovano, G, Dell'Era, V, Cai, R, Presotto, L, Paternò, G, Pappadà, G, Giussani, C, Sganzerla, E, Ferrarese, C, CARONE, DAVIDE, BERETTA, SIMONE, CUCCIONE, ELISA, RIVA, MATTEO, PADOVANO, GIADA, PRESOTTO, LUCA, GIUSSANI, CARLO GIORGIO, SGANZERLA, ERIK PIETRO, FERRARESE, CARLO, and Pappadà, GB
- Abstract
Objective: intracranial collateral circulation performance is emerging as a strong outcome determinant in both human and experimental ischemic stroke. The aim of this study was to investigate and compare the effects of two putative strategies, which might actively modulate intracranial collateral flow in the setting of acute cerebral ischemia: intravascular volume load using polygeline and cerebro-selective vasodilatation using acetazolamide. Materials and methods: MCA was transiently occluded (90 min) by intraluminal filament in adult male Wistar rats. 10 rats were left untreated; 30 rats were treated after 30 min of ischemia with intravenous administration of either saline solution (n=10), polygeline (n=10) or acetazolamide (n =10). Intracranial collateral flow was studied in terms of perfusion deficit using multi-site laser Doppler monitoring, functional deficit was assessed using a sensory-motor score and infarct volume was calculated on consecutive sections stained with Cresyl violet, performed 24 hours after ischemia induction. Blood pressure, heart and respiratory rate were continuously monitored by a pressure transducer placed in femoral artery. Results: post-ischemic administration of both polygeline and acetazolamide significantly increased intracranial collateral flow in the territory of leptomeningeal branches during MCA occlusion and reduced infarct size as well as functional deficit, compared to untreated and saline-treated rats. No significant effect on blood pressure was observed. Conclusions: therapeutic modulation of intracranial collateral flow is feasible and is associated with a better outcome after transient MCA occlusion in rats. “Collateral therapeutics” may represent an simple tissue-saving strategy in the hyper-acute phase of ischemic stroke prior to recanalization therapy.
- Published
- 2014
32. Intracranial collateral flow defines the boundaries of molecular penumbra in experimental ischemic stroke
- Author
-
Beretta, S, Cuccione, E, Versace, A, Carone, D, Riva, M, Padovano, G, Dell'Era, V, Cai, R, Presotto, L, Rousseau, D, Chaveau, F, Paternò, G, Pappadà, G, Giussani, C, Sganzerla, E, Ferrarese, C, BERETTA, SIMONE, CUCCIONE, ELISA, CARONE, DAVIDE, RIVA, MATTEO, PADOVANO, GIADA, PRESOTTO, LUCA, GIUSSANI, CARLO GIORGIO, SGANZERLA, ERIK PIETRO, FERRARESE, CARLO, Pappadà, GB, Beretta, S, Cuccione, E, Versace, A, Carone, D, Riva, M, Padovano, G, Dell'Era, V, Cai, R, Presotto, L, Rousseau, D, Chaveau, F, Paternò, G, Pappadà, G, Giussani, C, Sganzerla, E, Ferrarese, C, BERETTA, SIMONE, CUCCIONE, ELISA, CARONE, DAVIDE, RIVA, MATTEO, PADOVANO, GIADA, PRESOTTO, LUCA, GIUSSANI, CARLO GIORGIO, SGANZERLA, ERIK PIETRO, FERRARESE, CARLO, and Pappadà, GB
- Abstract
Objective: Intracranial collaterals are dynamically recruited after arterial occlusion and are emerging as a strong determinant of tissue outcome in both human and experimental ischemic stroke. The relationship between collateral flow and ischemic penumbra remains largely unexplored in pre-clinical studies. The aim of the present study was to investigate the pattern of collateral flow with regards of penumbral tissue in rats after transient middle cerebral artery (MCA) occlusion. Materials and methods: MCA was transiently occluded (90 minutes) by intraluminal filament in adult male Wistar rats (n=25). Intracranial collateral flow was studied in term of perfusion deficit and biosignal fluctuation analysis using multi-site laser Doppler monitoring in the borderzone territory between MCA and anterior cerebral artery and in the central MCA territory. Molecular penumbra was defined by topographical mapping and quantitative signal analysis of HSP70 immunohistochemistry. Functional deficit was assessed using a 18-points sensory-motor score and infarct volume was calculated on consecutive sections stained with Cresyl violet, performed 24 hours after ischemia induction. Results: The degree of functional performance of intracranial collaterals in the territory of leptomeningeal branches during MCA occlusion inversely correlated with HSP70 immunoreactive areas in both cortex and striatum, as well as with infarct size and functional deficit, and predicted of the amount of intact tissue after MCA occlusion followed by reperfusion. Conclusions: Intracranial collateral flow is associated with reduced areas of both molecular penumbra and ischemic core and increased areas of intact tissue in rats subjected to MCA occlusion followed by reperfusion. Our findings prompt the development of collateral therapeutics to provide tissue-saving strategies in the hyper-acute phase of ischemic stroke prior to recanalization therapy.
- Published
- 2014
33. Craniovertebral junction pathological features and their management in the mucopolysaccharidoses
- Author
-
Sganzerla, E, Giussani, C, Grimaldi, M, Parini, R, Ingelmo, P, Trezza, A, Visocchi, M, SGANZERLA, ERIK PIETRO, GIUSSANI, CARLO GIORGIO, Visocchi, M., Sganzerla, E, Giussani, C, Grimaldi, M, Parini, R, Ingelmo, P, Trezza, A, Visocchi, M, SGANZERLA, ERIK PIETRO, GIUSSANI, CARLO GIORGIO, and Visocchi, M.
- Abstract
The mucopolysaccharidoses (MPS) are multisystemic inherited metabolic diseases caused by the deficiency of the enzymes involved in the degradation of glycosaminoglycans (GAGs), which variably involve the central nervous system, heart, lungs, and bones.Undegraded or only partly degraded GAGs accumulate in the extracellular matrix, joint fluid, and connective tissue leading to widespread tissue and organ dysfunction.The introduction of hematopoietic stem cell transplantation (HSCT) and enzyme replacement therapy (ERT) has positively affected the natural history of MPS patients and their life expectancy. However, the presence of spinal abnormalities and deposition of GAGs in soft tissues remains nearly unaltered.Abnormalities of the craniovertebral junction (CVJ) and GAG deposits can result in spinal cord compression with slowly progressive myelopathy or acute posttraumatic tetraplegia.The current paper discusses neuroimaging findings in a consecutive series of 42 MPS patients followed at our Center for Metabolic Diseases and their neurosurgical issues.Current recommendations for decompression and fusion will be discussed according to our experience and review of the literature
- Published
- 2014
34. Oncogenic osteomalacia caused by a phosphaturic mesenchymal tumor of the thoracic spine
- Author
-
PIROLA, ELENA, VERGANI, FRANCESCO, CASIRAGHI, PAOLO, SGANZERLA, ERIK PIETRO, Leone, EB, Guerra, P, LEONE, BIAGIO EUGENIO, Pirola, E, Vergani, F, Casiraghi, P, Leone, E, Guerra, P, Sganzerla, E, and Leone, B
- Subjects
Male ,Spinal Neoplasms ,Paraneoplastic Syndromes ,Spinal Neoplasm ,Middle Aged ,MED/27 - NEUROCHIRURGIA ,Magnetic Resonance Imaging ,Thoracic Vertebrae ,Spinal Fusion ,Paraneoplastic Syndrome ,Osteomalacia ,Mesenchymoma ,Humans ,Hypophosphatemia, Familial - Abstract
Phosphaturic mesenchymal tumors that cause the paraneoplastic syndrome known as oncogenic osteomalacia are rare. The authors report on the case of a 57-year-old man with a history of osteomalacia and in whom was diagnosed a thoracic spine tumor at the T-4 level. Complete tumor resection was accomplished. The histological diagnosis was phosphaturic mesenchymal tumor (mixed connective tissue variant). After lesion removal, the paraneoplastic syndrome resolved. At the 24-month follow-up, no recurrence of the disease was observed. The clinical presentation, surgical technique, and follow-up in this case were reviewed in detail.
- Published
- 2009
35. Psychiatric evaluation of patients with Parkinson’s disease candidate sto deep brain stimulation: results of a case-control study
- Author
-
Giampieri, E, Beghi, M, Paggi, E, Mason, E, Scialò, C, Landi, A, Vergani, F, Carta, I, Gaini, SM, SGANZERLA, ERIK PIETRO, CORNAGGIA, CESARE MARIA, Giampieri, E, Beghi, M, Paggi, E, Mason, E, Scialò, C, Landi, A, Vergani, F, Carta, I, Cornaggia, C, Gaini, S, and Sganzerla, E
- Subjects
Parkinson's disease ,deep brain stimulation - Published
- 2008
36. Ganglioglioma of the spinal cord in neurofibromatosis type 1
- Author
-
Giussani, C, Isimbaldi, G, Massimino, M, Trezza, A, Cianci, P, Canonico, F, Sganzerla, E, GIUSSANI, CARLO GIORGIO, SGANZERLA, ERIK PIETRO, Giussani, C, Isimbaldi, G, Massimino, M, Trezza, A, Cianci, P, Canonico, F, Sganzerla, E, GIUSSANI, CARLO GIORGIO, and SGANZERLA, ERIK PIETRO
- Abstract
The oncologic involvement of the spinal cord in neurofibromatosis type 1 (NF1) is not a typical feature of the disease. Here, we present a case of ganglioglioma of the spinal cord in a child with NF1 and try to define if this tumor can be considered coincidental or not. A 4-year-old boy affected by NF1 was diagnosed with a spinal cord-enhancing tumor extending from C4 to D3, with a disappearance in the T2 MRI sequences of the cerebrospinal fluid signal. The patient underwent a subtotal resection. The pathological exam revealed a ganglioglioma. To the best of our knowledge, only 1 other case of spinal cord ganglioglioma has been described in an NF1 patient. We suggest considering ganglioglioma in the differential diagnosis of an NF1 patient with a spinal cord tumor due to its favorable survival rate, especially in relation to the anatomical and surgical issues of this tumor that do not always entail a gross total resection. © 2013 S. Karger AG, Basel.
- Published
- 2013
37. Optimized system for cerebral perfusion monitoring in the rat stroke model of intraluminal middle cerebral artery occlusion
- Author
-
Beretta, S, Riva, M, Carone, D, Cuccione, E, Padovano, G, RODRIGUEZ MENENDEZ, V, Pappadá, G, Versace, A, Giussani, C, Sganzerla, E, Ferrarese, C, CARONE, DAVIDE, CUCCIONE, ELISA, RODRIGUEZ MENENDEZ, VIRGINIA, GIUSSANI, CARLO GIORGIO, SGANZERLA, ERIK PIETRO, FERRARESE, CARLO, Beretta, S, Riva, M, Carone, D, Cuccione, E, Padovano, G, RODRIGUEZ MENENDEZ, V, Pappadá, G, Versace, A, Giussani, C, Sganzerla, E, Ferrarese, C, CARONE, DAVIDE, CUCCIONE, ELISA, RODRIGUEZ MENENDEZ, VIRGINIA, GIUSSANI, CARLO GIORGIO, SGANZERLA, ERIK PIETRO, and FERRARESE, CARLO
- Abstract
The translational potential of pre-clinical stroke research depends on the accuracy of experimental modeling. Cerebral perfusion monitoring in animal models of acute ischemic stroke allows to confirm successful arterial occlusion and exclude subarachnoid hemorrhage. Cerebral perfusion monitoring can also be used to study intracranial collateral circulation, which is emerging as a powerful determinant of stroke outcome and a possible therapeutic target. Despite a recognized role of Laser Doppler perfusion monitoring as part of the current guidelines for experimental cerebral ischemia, a number of technical difficulties exist that limit its widespread use. One of the major issues is obtaining a secure and prolonged attachment of a deep-penetration Laser Doppler probe to the animal skull. In this video, we show our optimized system for cerebral perfusion monitoring during transient middle cerebral artery occlusion by intraluminal filament in the rat. We developed in-house a simple method to obtain a custom made holder for twin-fibre (deep-penetration) Laser Doppler probes, which allow multi-site monitoring if needed. A continuous and prolonged monitoring of cerebral perfusion could easily be obtained over the intact skull
- Published
- 2013
38. Hemodynamic monitoring of intracranial collateral flow predicts tissue and functional outcome in experimental ischemic stroke
- Author
-
Beretta, S, Riva, M, Pappadà, G, Papadakis, M, Cuccione, E, Carone, D, RODRIGUEZ MENENDEZ, V, Sganzerla, E, Ferrarese, C, BERETTA, SIMONE, RIVA, MATTEO, CUCCIONE, ELISA, CARONE, DAVIDE, RODRIGUEZ MENENDEZ, VIRGINIA, SGANZERLA, ERIK PIETRO, FERRARESE, CARLO, Pappadà, GB, Beretta, S, Riva, M, Pappadà, G, Papadakis, M, Cuccione, E, Carone, D, RODRIGUEZ MENENDEZ, V, Sganzerla, E, Ferrarese, C, BERETTA, SIMONE, RIVA, MATTEO, CUCCIONE, ELISA, CARONE, DAVIDE, RODRIGUEZ MENENDEZ, VIRGINIA, SGANZERLA, ERIK PIETRO, FERRARESE, CARLO, and Pappadà, GB
- Abstract
Intracranial collaterals provide residual blood flow to penumbral tissue in acute ischemic stroke and contribute to infarct size variability in humans. In the present study, hemodynamic monitoring of the borderzone territory between the leptomeningeal branches of middle cerebral artery and anterior cerebral artery was compared to lateral middle cerebral artery territory, during common carotid artery occlusion and middle cerebral artery occlusion in rats. The functional performance of intracranial collaterals, shown by perfusion deficit in the territory of leptomeningeal branches either during common carotid artery occlusion or middle cerebral artery occlusion, showed significant variability among animals and consistently predicted infarct size and functional deficit. Our findings indicate that leptomeningeal collateral flow is a strong predictor of stroke severity in rats, similarly to humans. Monitoring of collateral blood flow in experimental stroke is essential for reducing variability in neuroprotection studies and accelerating the development of collateral therapeutics
- Published
- 2012
39. Intracranial collateral flow in experimental ischemic stroke. From hemodynamic monitoring to collateral therapeutics
- Author
-
Beretta, S, Riva, M, Cuccione, E, Carone, D, Padovano, G, Versace, A, RODRIGUEZ MENENDEZ, V, Pappadà, G, Sganzerla, E, Papadakis, M, Ferrarese, C, BERETTA, SIMONE, RIVA, MATTEO, CUCCIONE, ELISA, CARONE, DAVIDE, PADOVANO, GIADA, RODRIGUEZ MENENDEZ, VIRGINIA, SGANZERLA, ERIK PIETRO, FERRARESE, CARLO, Pappadà, GB, Beretta, S, Riva, M, Cuccione, E, Carone, D, Padovano, G, Versace, A, RODRIGUEZ MENENDEZ, V, Pappadà, G, Sganzerla, E, Papadakis, M, Ferrarese, C, BERETTA, SIMONE, RIVA, MATTEO, CUCCIONE, ELISA, CARONE, DAVIDE, PADOVANO, GIADA, RODRIGUEZ MENENDEZ, VIRGINIA, SGANZERLA, ERIK PIETRO, FERRARESE, CARLO, and Pappadà, GB
- Published
- 2012
40. The association of neural axis and craniovertebral junction anomalies with scoliosis in Rubinstein-Taybi syndrome
- Author
-
Giussani, C, Selicorni, A, Fossati, C, Ingelmo, P, Canonico, F, Landi, A, Trezza, A, Riva, M, Sganzerla, E, GIUSSANI, CARLO GIORGIO, SGANZERLA, ERIK PIETRO, Giussani, C, Selicorni, A, Fossati, C, Ingelmo, P, Canonico, F, Landi, A, Trezza, A, Riva, M, Sganzerla, E, GIUSSANI, CARLO GIORGIO, and SGANZERLA, ERIK PIETRO
- Abstract
Object Rubinstein-Taybi syndrome (RSTS) is a rare condition with characteristic genetic and clinical features. The presence of variable vertebral and neural axis abnormalities has been reported in the literature. We describe the possible association of multiple different spinal anomalies in these patients. Results The radiological exams of two RSTS patients (a female and male of 11 and 13 years) have been reviewed. Both patients presented the simultaneous association of craniovertebral junction bony abnormalities (occipito-C1 condyle subluxation and posterior C2-C3 arches fusion), Chiari I malformation, spinal cord syrinx, low-lying conus medullaris, and scoliosis. Conclusion An association of different spinal cord anomalies is possible in RSTS patients and has to be investigated with a comprehensive neuroimaging study in order to address the proper treatment and prevent the development of neurologic deficits. © Springer-Verlag 2012.
- Published
- 2012
41. Hemodynamic monitoring of intracranial collateral flow predicts tissue and functional outcome in experimental ischemic stroke
- Author
-
Riva, M, Pappadà, G, Papadakis, M, Cuccione, E, Carone, D, RODRIGUEZ MENENDEZ, V, Sganzerla, E, Beretta, S, RIVA, MATTEO, CUCCIONE, ELISA, CARONE, DAVIDE, RODRIGUEZ MENENDEZ, VIRGINIA, SGANZERLA, ERIK PIETRO, BERETTA, SIMONE, Pappadà, GB, Riva, M, Pappadà, G, Papadakis, M, Cuccione, E, Carone, D, RODRIGUEZ MENENDEZ, V, Sganzerla, E, Beretta, S, RIVA, MATTEO, CUCCIONE, ELISA, CARONE, DAVIDE, RODRIGUEZ MENENDEZ, VIRGINIA, SGANZERLA, ERIK PIETRO, BERETTA, SIMONE, and Pappadà, GB
- Abstract
Intracranial collaterals provide residual blood flow to penumbral tissue in acute ischemic stroke and contribute to infarct size variability in humans. In the present study, hemodynamic monitoring of the borderzone territory between the leptomeningeal branches of middle cerebral artery and anterior cerebral artery was compared to lateral middle cerebral artery territory, during common carotid artery occlusion and middle cerebral artery occlusion in rats. The functional performance of intracranial collaterals, shown by perfusion deficit in the territory of leptomeningeal branches either during common carotid artery occlusion or middle cerebral artery occlusion, showed significant variability among animals and consistently predicted infarct size and functional deficit. Our findings indicate that leptomeningeal collateral flow is a strong predictor of stroke severity in rats, similarly to humans. Monitoring of collateral blood flow in experimental stroke is essential for reducing variability in neuroprotection studies and accelerating the development of collateral therapeutics
- Published
- 2012
42. Vagal Nerve Stimulation for the treatment of refractory symptomatic infantile spasms
- Author
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Landi, A, Pirillo, D, Grioni, D, Fiori, L, Carrara, C, Sganzerla, E, SGANZERLA, ERIK PIETRO, Landi, A, Pirillo, D, Grioni, D, Fiori, L, Carrara, C, Sganzerla, E, and SGANZERLA, ERIK PIETRO
- Published
- 2011
43. Cavum veli interpositi: just an anatomical variant or a potentially symptomatic CSF compartmentalization?
- Author
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Giussani, C, Fiori, L, Trezza, A, Riva, M, Sganzerla, E, GIUSSANI, CARLO GIORGIO, RIVA, MATTEO, SGANZERLA, ERIK PIETRO, Giussani, C, Fiori, L, Trezza, A, Riva, M, Sganzerla, E, GIUSSANI, CARLO GIORGIO, RIVA, MATTEO, and SGANZERLA, ERIK PIETRO
- Abstract
Background: The cavum veli interpositi (CVI) usually is a small CSF-containing abnormality of septum pellucidum, asymptomatic and rare after the age of 3 years. When symptomatic, it is large and can be related to psychiatric disorders, syndromic association of mental retardation and seizures or to hydrocephalus. Methods: This is the first reported case of an otherwise healthy pediatric patient with a large CVI experiencing episodes of hypertonic loss of consciousness unrelated to epileptic, cardiologic or psychiatric causes without signs of chronic increase in intracranial pressure (ICP). Results: Supposing a CSF compartmentalization in the CVI as the cause of acute poussés of ICP due to block of CSF pathways and considering the severity of the symptoms, an endoscopic fenestration was performed with a reduction of cyst dimensions. Conclusion: We suggest considering the fenestration of large CVI even in otherwise asymptomatic patients to avoid the risk of CSF compartmentalization with ICP poussés. © 2012 S. Karger AG, Basel.
- Published
- 2011
44. Cortical visual evoked potentials recorded after optic tract near field stimulation during GPi-DBS in non-cooperative patients
- Author
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Landi, A, Pirillo, D, Cilia, R, Antonini, A, Sganzerla, E, SGANZERLA, ERIK PIETRO, Landi, A, Pirillo, D, Cilia, R, Antonini, A, Sganzerla, E, and SGANZERLA, ERIK PIETRO
- Abstract
Object: Neurophysiologic monitoring during deep brain stimulation (DBS) interventions in the globus pallidus internum (Gpi) for the treatment of Parkinson's disease or primary dystonia is generally based upon microelectrode recordings (MER); moreover, MER request sophisticated technology and high level trained personnel for a reliable monitoring. Recordings of cortical visual evoked potentials (CVEPs) obtained after stimulation of the optic tract may be a potential option to MER; since optic tract lies just beneath the best target for Gpi DBS, changes in CVEPs during intraoperative exploration may drive a correct electrode positioning. Patients and methods: Cortical VEPs from optic tract stimulation (OT C-CEPs) have been recorded in seven patients during GPi-DBS for the treatment of Parkinson's disease and primary dystonia under general sedation. OT C-VEPs were obtained after near-field monopolar stimulation of the optic tract; recording electrodes were at the scalp. Cortical responses after optic tract versus standard visual stimulation were compared. Results: After intraoperative near-field OT stimulation a biphasic wave, named N40-P70, was detected in all cases. N40-P70 neither change in morphology nor in latency at different depths, but increased in amplitude approaching the optic tract. The electrode tip was positioned just 1 mm above the point where OT-CVEPs showed the larger amplitude. No MERs were obtained in these patients; OT CVEPs were the only method to detect the Gpi before positioning the electrodes. Conclusions: OT CVEPs seem to be as reliable as MER to detail the optimal target in Gpi surgery: in addition they are less expensive, faster to perform and easier to decode. © 2010 Elsevier B.V.
- Published
- 2011
45. Anatomical correlates for category-specific naming of living and non-living things
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Giussani, C, Riva, M, Gallucci, M, Boukhatem, L, Sganzerla, E, Demonet, J, Roux, F, GIUSSANI, CARLO GIORGIO, GALLUCCI, MARCELLO, SGANZERLA, ERIK PIETRO, Demonet, JF, Roux, FE, Giussani, C, Riva, M, Gallucci, M, Boukhatem, L, Sganzerla, E, Demonet, J, Roux, F, GIUSSANI, CARLO GIORGIO, GALLUCCI, MARCELLO, SGANZERLA, ERIK PIETRO, Demonet, JF, and Roux, FE
- Abstract
Introduction: Selective naming categories impairments for living and non-living things are widely reported in brain damaged patients. Electrostimulation mapping was used to study the possible anatomical segregation of living/non-living categories in a prospective series of patients operated on for tumor removal. Materials and methods: Fifty brain mappings (patients with no language impairment; range: 14-80. years; mean: 48. years; 26 males; 5 left handed) were performed in 46 left and 4 right hemispheres using two linguistically controlled tasks (naming for living and non-living things) during an awake surgery procedure. Fifteen regions and four macro cortical areas were designed to analyze the distribution of the interference sites. Results: Over 761 sites stimulated in the lateral hemispheres, 130 naming interferences sites were detected in small cortical areas (<1cm2). High individual variability was observed for living/non-living word retrieval localization and organization with a majority (62%) of shared living/non-living interferences. Specific living (12%) or non-living (26%) interferences were found too. In group analysis, no statistical significant anatomical localization was observed for living items in left lateral hemispheric cortex. A statistical significant representation of interference sites for non-living objects was found (Generalized Estimating Equation methodology, z-test=2.28, p=0.027) in the left posterolateral temporoparietal cortex. No influence of histopathology, gender and age on anatomical localization of naming categories was detected. Conclusion: The existence of dedicated neural structures for naming non-living things in the left posterolateral temporoparietal cortex is supported by this study although high individual differences exist in the organization of word categories retrieval. © 2011 Elsevier Inc.
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- 2011
46. Malattie del Sistema Nervoso
- Author
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FERRARESE, CARLO, APPOLLONIO, ILDEBRANDO, CAVALETTI, GUIDO ANGELO, SGANZERLA, ERIK PIETRO, Cortelli, P, Feferico, A, Marciani, MG, Ferrarese, C, Appollonio, I, Cavaletti, G, Marciani, M, Sganzerla, E, FERRARESE, CARLO, APPOLLONIO, ILDEBRANDO, CAVALETTI, GUIDO ANGELO, SGANZERLA, ERIK PIETRO, Cortelli, P, Feferico, A, Marciani, MG, Ferrarese, C, Appollonio, I, Cavaletti, G, Marciani, M, and Sganzerla, E
- Abstract
Malattie del sistema nervoso è un testo pratico e didattico, che vuole orientare gli studenti attraverso i principali problemi neurologici, la conoscenza della semeiotica, della clinica e della terapia, senza trascurare la dinamicità della disciplina che negli ultimi anni ha fatto progressi eccezionali. Il testo si avvicina allo studio delle singole patologie in modo clinico, con un’attenzione particolare ai criteri diagnostici, a flow-charts diagnostico-terapeutiche e alla diagnosi differenziale. Le potenzialità terapeutiche mediche e chirurgiche vengono opportunamente illustrate e discusse, anche alla luce di recenti trials e dell’evidence based medicine. Gli sviluppi della ricerca, che nel futuro porterà a nuove possibilità terapeutiche, sono richiamati in ogni capitolo (dala quarta di copertina).
- Published
- 2011
47. Neurosurgical complications and their management in mucopolysaccharidosis
- Author
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Parini, R, Andria, G, Giussani, C, Miori, S, Sganzerla, E, GIUSSANI, CARLO GIORGIO, SGANZERLA, ERIK PIETRO, Parini, R, Andria, G, Giussani, C, Miori, S, Sganzerla, E, GIUSSANI, CARLO GIORGIO, and SGANZERLA, ERIK PIETRO
- Published
- 2010
48. Surgical, medical, and hardware adverse events in a series of 141 patients undergoing subthalamic deep brain stimulation for Parkinson disease
- Author
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Vergani, F, Landi, A, Pirillo, D, Cilia, R, Antonini, A, Sganzerla, E, SGANZERLA, ERIK PIETRO, Vergani, F, Landi, A, Pirillo, D, Cilia, R, Antonini, A, Sganzerla, E, and SGANZERLA, ERIK PIETRO
- Abstract
Background: Subthalamic deep brain stimulation has proved significant efficacy in the treatment of Parkinson disease. Adverse events, due to surgical and hardware-related complications, must be clearly addressed to properly balance the cost-effectiveness of the therapy. In addition, limited data exists about medical adverse events after surgery. Methods: One hundred forty-one patients undergoing subthalamic deep brain stimulation for Parkinson disease from 1998 to 2007 were considered. Medical records, operative notes, clinical findings at follow-up and final outcome were accurately recorded to identify surgical- and hardware-related complications, infections and delayed adverse medical events. Results: Five hundred twenty-two surgical procedures were performed, including electrodes positioning and impulse programmable generators implantation and substitutions. Mean follow-up of the patients was 4.6 years (9 months10 years). Surgical complications were observed in 5.6% of patients, including two hemorrhages (1.4%) and three (2.1%) inabilities to complete the surgical procedure. Medical delayed adverse events affected 1.4% of patients, with a patient having a fatal aspiration pneumonia. Infections were seen in 5.6% of patients; removal of the hardware was necessary in 3.6%. Hardware-adverse events were observed in 7% of patients, generally requiring minor surgery. Direct surgical mortality was 0%; overall mortality was 0.7% and permanent surgical morbidity was 0.7%. Conclusions: Deep brain stimulation can be regarded as a safe procedure. Mortality and permanent morbidity are very low, and surgical complications are relatively rare. Nevertheless, minor complications are not infrequent; hence the importance of continuous monitoring of the patients during the follow-up period. © 2010 Elsevier Inc.
- Published
- 2010
49. Is preoperative functional magnetic resonance imaging reliable for language areas mapping in brain tumor surgery? Review of language functional magnetic resonance imaging and direct cortical stimulation correlation studies
- Author
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Giussani, C, Roux, F, Ojemann, J, Sganzerla, E, Pirillo, D, Papagno, C, GIUSSANI, CARLO GIORGIO, Roux, FE, Ojemann, JG, SGANZERLA, ERIK PIETRO, PAPAGNO, COSTANZA, Giussani, C, Roux, F, Ojemann, J, Sganzerla, E, Pirillo, D, Papagno, C, GIUSSANI, CARLO GIORGIO, Roux, FE, Ojemann, JG, SGANZERLA, ERIK PIETRO, and PAPAGNO, COSTANZA
- Abstract
OBJECTIVE: Language functional magnetic resonance imaging (fMRI) has been used extensively in the past decade for both clinical and research purposes. Its integration in the preoperative imaging assessment of brain lesions involving eloquent areas is progressively more diffused in neurosurgical practice. Nevertheless, the reliability of language fMRI is unclear. To understand the reliability of preoperative language fMRI in patients operated on for brain tumors, the surgical studies that compared language fMRI with direct cortical stimulation (DCS) were reviewed. METHODS: Articles comparing language fMRI with DCS of language areas were reviewed with attention to the lesion pathology, the magnetic field, the language tasks used pre- and intraoperatively, and the validation modalities adopted to establish the reliability of language fMRI. We tried to explore the effectiveness of language fMRI in gliomas. RESULTS: Nine language brain mapping studies compared the findings of fMRI with those of DCS. The studies are not homogeneous for tumor types, magnetic fields, pre- and intraoperative language tasks, intraoperative matching criteria, and results. Sensitivity and specificity were calculated in 5 studies (respectively ranging from 59% to 100% and from 0% to 97%). CONCLUSION: The contradictory results of these studies do not allow consideration of language fMRI as an alternative tool to DCS in brain lesions located in language areas, especially in gliomas because of the pattern of growth of these tumors. However, language fMRI conducted with high magnet fields is a promising brain mapping tool that must be validated by DCS in methodological robust studies. Copyright © 2010 by the Congress of Neurological Surgeons
- Published
- 2010
50. Oncogenic osteomalacia caused by a phosphaturic mesenchymal tumor of the thoracic spine
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Pirola, E, Vergani, F, Casiraghi, P, Leone, E, Guerra, P, Sganzerla, E, Leone, B, PIROLA, ELENA, VERGANI, FRANCESCO, CASIRAGHI, PAOLO, SGANZERLA, ERIK PIETRO, Leone, EB, LEONE, BIAGIO EUGENIO, Pirola, E, Vergani, F, Casiraghi, P, Leone, E, Guerra, P, Sganzerla, E, Leone, B, PIROLA, ELENA, VERGANI, FRANCESCO, CASIRAGHI, PAOLO, SGANZERLA, ERIK PIETRO, Leone, EB, and LEONE, BIAGIO EUGENIO
- Abstract
Phosphaturic mesenchymal tumors that cause the paraneoplastic syndrome known as oncogenic osteomalacia are rare. The authors report on the case of a 57-year-old man with a history of osteomalacia and in whom was diagnosed a thoracic spine tumor at the T-4 level. Complete tumor resection was accomplished. The histological diagnosis was phosphaturic mesenchymal tumor (mixed connective tissue variant). After lesion removal, the paraneoplastic syndrome resolved. At the 24-month follow-up, no recurrence of the disease was observed. The clinical presentation, surgical technique, and follow-up in this case were reviewed in detail.
- Published
- 2009
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