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BackgroundDiagnosis of alcohol use disorder (AUD) in primary care is critical for increasing access to alcohol treatment. However, AUD is underdiagnosed and may be inequitably diagnosed due to societal structures that determine access to resources (e.g., structural racism that limits opportunities for some groups and influences interpersonal interactions in and beyond health care). This study described patterns of provider-documented AUD in primary care across intersections of race, ethnicity, sex, and community-level socioeconomic status (SES).MethodsThis cross-sectional study used EHR data from a regional healthcare system with 35 primary care clinics that included adult patients who completed alcohol screenings between 3/1/2015 and 9/30/2020. The prevalence of provider-documented AUD in primary care based on International Classification of Diseases-9 (ICD-9) and ICD-10 diagnoses was compared across intersections of race, ethnicity, sex, and community-level SES.ResultsAmong 439,375 patients, 6.6% were Latine, 11.0% Asian, 5.4% Black, 1.3% Native Hawaiian/Pacific Islander (NH/PI), 1.5% American Indian/Alaska Native (AI/AN), and 74.2% White, and 58.3% women. The overall prevalence of provider-documented AUD was 1.0% and varied across intersecting identities. Among women, the prevalence was highest for AI/AN women with middle SES, 1.5% (95% CI 1.0-2.3), and lowest for Asian women with middle SES, 0.1% (95% CI 0.1-0.2). Among men, the prevalence was highest for AI/AN men with high and middle SES, 2.0% (95% CI 1.1-3.4) and 2.0% (95% CI 1.2-3.2), respectively, and lowest for Asian men with high SES, 0.5% (95% CI 0.3-0.7). Black and Latine patients tended to have a lower prevalence of AUD than White patients, across all intersections of sex and SES except for Black women with high SES. There were no consistent patterns of the prevalence of AUD diagnosis that emerged across SES.ConclusionThe prevalence of provider-documented AUD in primary care was highest in AI/AN men and women and lowest in Asian men and women. Findings of lower prevalence of provider-documented AUD in Black and Hispanic than White patients across most intersections of sex and SES differed from prior studies. Findings may suggest that differences in access to resources, which vary in effects across these identity characteristics and lived experiences, influence the diagnosis of AUD in clinical care.

Developing the ability to regulate actions, thoughts, and emotions is necessary for successfully engaging in goal-directed activities, which form the essence of success in many life situations. In this regard, executive function (EF), as an aspect of these top-down control processes, has been the subject of inquiry in many developmental studies aiming to identify its link with various other aspects of a child's life, including family socioeconomic status (SES). This article presents a critical look at the association between family SES and childhood EF by reviewing studies that provide contrasting perspectives compared to the generally reported positive correlation between these two constructs. We first address the various aspects of assessing SES and childhood EF, emphasizing their multifaceted nature. Next, we discuss the interplays between different components of these two constructs, especially as it unfolds in various cultural contexts. Finally, we conclude by discussing mainly neglected lines of research that could further improve our understanding of the extent of socioeconomic impacts on child development, specifically regarding executive function. Considering these lines of research is a necessary step to a more accurate analysis of the link between socioeconomic factors and childhood executive function. [ABSTRACT FROM AUTHOR]

Introduction: Exposure to family risk factors increases adolescents' chances of attaining a lower educational level. However, some adolescents attain a high educational level despite being exposed to family risk factors such as a lower parental socioeconomic status (SES) or receiving less family support. Method: Using data from the Dutch TRAILS cohort study (NT1 = 2175; Mage = 11.1, SD = 0.55, 50.8% female), we investigated if higher levels of effortful control and peer support can buffer against the negative effects of a lower parental SES and less family support on educational level. Two multinomial logistic regressions were performed (from early to mid‐adolescence and from mid‐adolescence to young adulthood) with post hoc tests to contrast four ordinal educational levels: practical vocational, theoretical vocational, higher general, and (pre‐)university. Results: Adolescents with a higher parental SES were consistently more likely to end up at a higher educational level, but family support was hardly associated with educational level. Neither effortful control nor peer support buffered the associations of parental SES and family support with educational level. Effortful control did have a positive direct (compensatory) effect on the educational level. Conclusion: We conclude that other individual competencies or more structural changes may be more helpful buffers for reducing socioeconomic inequalities in educational attainment. [ABSTRACT FROM AUTHOR]

A positive association between pubertal maturity as assessed by skeletal development, and specific cognitive abilities has recently been demonstrated in a cohort of adolescent girls. The current study explores the impact of chronological age and relative pubertal maturity on executive function within the same cohort. Relative maturity, determined by the difference between chronological age and skeletal age, establishes the criteria for enrolling participants into average, advanced, or delayed relative maturity subgroups. Performance is assessed using the Numerical Stroop test and analyzed across four conditions, each with varying task requirements related to inhibition and task switching. The effects of chronological age and relative maturity on executive functions are tested by a linear mixed model. Within the examined age-range (12–15 y), a more protracted development was found for inhibition as compared to switching. In line with the previous findings, the results reveal significant development in executive performance as a function of chronological age, and relative maturity also demonstrated significant effect on the development of executing functioning. The significant interaction effect between Chronological Age and Relative Maturity suggests that the degree of interplay between these factors varies across the examined age range. Specifically, relative maturity may have a more noticeable impact on EF functioning in middle adolescence compared to early adolescence. [ABSTRACT FROM AUTHOR]

The United Nations' Convention on Biological Diversity set forth the 30 × 30 target, an agenda for countries to protect at least 30% of their terrestrial, inland water, and coastal and marine areas by 2030. With <6 years to reach that goal, riverine conservation professionals are faced with the difficult decision of prioritizing which rivers or river segments should be conserved (protected and/or restored). While incorporating resilience into conservation planning is essential for enhancing, restoring, and maintaining the vital riverine ecosystem services (ES) most threatened by climate change and other environmental and human stresses, this paradigm is at odds with traditional conservation approaches that are either opportunistic or reactionary, where only unique and highly visible ecosystems have been prioritized. Barriers to implementing resilience‐based riverine conservation planning include: (1) difficulties in conceptualizing and quantifying resilience; (2) insufficient consideration of the social components of riverine systems; (3) the inapplicability of terrestrial‐only conservation models to aquatic systems; and (4) the traditional ad hoc and opportunistic approach to conservation. To overcome these barriers, we propose a resilience‐based riverine conservation framework that includes: (1) assessing riverine resilience using indicator frameworks; (2) considering rivers as dynamically coupled social–ecological systems; (3) explicitly incorporating terrestrial–aquatic network connectivity into conservation decision‐making; and (4) strategic systems planning using a novel resilience–conservation matrix as a tool. This framework has the potential to transform conservation practices around the globe to more effectively protect river systems and enhance their resilience to climate change and human development. This article is categorized under:Water and Life > Conservation, Management, and AwarenessScience of Water > Water and Environmental ChangeHuman Water > Water Governance [ABSTRACT FROM AUTHOR]

Soil ecological stoichiometry (SES) provides an important approach in exploring chemical element balance relationships and ecosystem structure and function, but the characterization, significance, and drivers of SES in saline–alkali areas have not been well studied. Soil organic carbon (SOC), total nitrogen (TN), and total phosphorus (TP) were measured and their SES ratios were calculated from 155 soil samples collected at a depth of 20 cm in the saline–alkali soil zone of western Jilin Province, China. The results showed that SOC, TN, and TP contents and SES ratios (52:4:3) were lower in this region than in terrestrial ecosystems both in China as a whole and globally. The distribution of SOC, TN, and TP in saline–alkali soil varied significantly across land use types, with high concentrations mainly in woodland, grassland, and cropland. SOC, TN, and TP were tightly coupled, with significant positive correlations (p < 0.01), and C:N was significantly negatively correlated (p < 0.01) with the other SES ratios, indicating that saline–alkali soils are susceptible to carbon and nitrogen limitation. The distribution patterns of SOC, TN, TP, and their eco‐chemometrics on the environmental gradient were variable, mainly in the form of significant decreases with increasing mean annual precipitation, mean annual temperature, and elevation. Cropland was most affected by environmental factors, and all SES except TP were affected by environmental factors. Soil nutrient (44.9%) and soil texture (9.8%) contributed the most to explaining SES in the saline–alkali soil zone, while climate (1.6%) and vegetation (0.4%) contributed the least to the explanation. All land use types were most explained by AN, except for woodland SES, which was most explained by AP. Elevation (17.4%) possessed a high degree of explanation for SES on underutilized land, except for the soil itself. Grassland is the land category most affected by climatic factors (12.7%). By applying biochar, nitrogen fertilizer, and planting saline‐tolerant crops such as Leymus chinensis, the soil structure can be effectively improved and the content of carbon and nitrogen in the soil can be increased, which has a positive effect on the improvement of saline–alkali soil. The results of the study provide information that can be used to help saline–alkali areas cope with environmental and climate change and restore degraded ecosystems. [ABSTRACT FROM AUTHOR]

Background. Climate change and continued development in the wildland--urban interface (WUI) have increased risks to property and infrastructure from destructive wildfires. Aims. A better understanding of the factors associated with building survival will promote resilience of WUI communities. Methods. We studied factors associated with the likelihood that a building burned during the 2019 McKinley fire in the Alaska boreal forest, USA. We examined the potential influence of both ecological or socio-economic factors on building loss. Key results. The probability of a building burning was significantly associated (P < 0.001) with a building burning nearby (within 30 m). Having less flammable deciduous cover nearby (within 100 m) improved survival. Buildings with lower value on larger parcels were more likely to burn, as were buildings with larger perimeters. Other important factors associated with burning included the number of buildings both nearby (within 30 m) and within the property parcel boundary. Conclusions. Our results suggest that social and ecological factors contribute to building survival, indicating that a comprehensive social-ecological approach would provide the most effective support to WUI communities with wildfire risks. Implications. A comprehensive approach that integrates social, economic, and ecological factors is important in understanding building loss in WUI wildfires. [ABSTRACT FROM AUTHOR]

Background: Low back pain (LBP) is a common health problem in workers that contributes to work disability and reduces quality of life. However, studies examining vulnerable groups in relation to sociodemographic differences in LBP remain scarce. Therefore, the current study investigates which sociodemographic groups of workers are most affected by LBP. Methods: Data from the 2018 BIBB/BAuA employment survey were used (N = 16252). Age, education, occupational group, income, working hours, atypical working time, relationship status, and having children were used as sociodemographic predictors. Gender-stratified logistic regression analyses and intersectional classification tree analyses were conducted. Results: A higher prevalence of LBP was observed for women compared to men. Significant differences in LBP emerged for age, working hours, atypical working time, occupational group and education, with some gender differences in the importance of predictors: Age was a significant predictor mostly in men as compared to women, atypical working hours had a slightly greater effect in women, whereas differences in LBP according to the occupational group were more pronounced for men. Vulnerable groups were found to be women who work in occupations other than professionals or managers, work atypical hours and have an intermediate or low educational level as well as men who work as skilled agricultural workers, craft workers, machine operators, or elementary occupations and are between 35 and 64 years old. Conclusions: Thus, workers with certain occupations and lower levels of education, middle-aged men and women with unfavourable working time characteristics are most affected by low back pain. These groups should be focused on to potentially increase healthy working life and prevent work disability. [ABSTRACT FROM AUTHOR]

Background: Gene–environment interaction (G × E) is likely an important influence shaping individual differences in alcohol misuse (AM), yet it has not been extensively studied in molecular genetic research. In this study, we use a series of genome‐wide gene–environment interaction (GWEIS) and in silico annotation methods with the aim of improving gene identification and biological understanding of AM. Methods: We carried out GWEIS for four AM phenotypes in the large UK Biobank sample (N = 360,314), with trauma exposure and socioeconomic status (SES) as moderators of the genetic effects. Exploratory analyses compared stratified genome‐wide association (GWAS) and GWEIS modeling approaches. We applied functional annotation, gene‐ and gene‐set enrichment, and polygenic score analyses to interpret the GWEIS results. Results: GWEIS models showed few genetic variants with significant interaction effects across gene–environment pairs. Enrichment analyses identified moderation by SES of the genes NOXA1, DLGAP1, and UBE2L3 on drinking quantity and the gene IFIT1B on drinking frequency. Except for DLGAP1, these genes have not previously been linked to AM. The most robust results (GWEIS interaction p = 4.59e‐09) were seen for SES moderating the effects of variants linked to immune‐related genes on a pattern of drinking with versus without meals. Conclusions: Our results highlight several genes and a potential mechanism of immune system functioning behind the moderating effect of SES on the genetic influences on AM. Although GWEIS seems to be a preferred approach over stratified GWAS, modeling G × E effects at the molecular level remains a challenge even in large samples. Understanding these effects will require substantial effort and more in‐depth phenotypic measurement. [ABSTRACT FROM AUTHOR]

Backgroud: Socioeconomic status (SES) plays a vital role in determining vaccination uptake and attitudes. Vaccine hesitancy varies among different communities, yet knowledge of vaccine attitudes among Asian-Americans is limited. Objective: This study aims to investigate the relationship between SES and vaccine attitudes among Asian-Americans in the State of New Jersey (NJ). Methods: Asian-Americans aged ≥ 18 years living in NJ were included (N = 157). SES was measured by education level, employment type, employment status, and household income. The primary outcomes were vaccine hesitancy, reluctance, and confidence for COVID-19, influenza, and pneumococcal vaccines. Descriptive and inferential statistics were performed. Multivariable logistic regression was used to identify associations between SES and vaccine hesitancy while controlling for confounders such as age, gender, birthplace, and religion. Results: Among 157 participants, 12.1% reported vaccine hesitancy. There was no statistically significant association between vaccine hesitancy and education level (p = 0.68), employment status (p = 1), employment type (p = 0.48), and household income (p = 0.15). Multivariable logistic regression modeling confirmed that none of the SES predictor variables were associated with vaccine hesitancy. However, as exploratory finding, gender was found to be a significant predictor, with males having lower odds of vaccine hesitancy than females (Adjusted OR = 0.14; p < 0.05). Confidence in influenza and pneumococcal vaccines increased during the pandemic, from 62.34% to 70.13% and from 59.2% to 70.51%, respectively. For the COVID-19 vaccine, 73.1% of participants reported having "a lot of confidence" in taking vaccine. Conclusion: Most sampled Asian-Americans in NJ have high confidence in taking COVID-19 vaccines, and there is no significant association between vaccine hesitancy and SES. [ABSTRACT FROM AUTHOR]

Background: Our aim was to identify dietary patterns by the level of maternal education that contribute to BMI, fat mass index (FMI), and fat-free mass index (FFMI) in children at age 5 and to assess if these dietary patterns are related to BMI at age 10. Methods: Per group (low/middle/high level), Reduced Rank Regression (RRR) was used to derive dietary patterns for the response variables BMI z-score, FMI, and FFMI in 1728 children at age 5 in the Amsterdam Born Children and their Development (ABCD) cohort. Regression analyses were then used to determine the association with BMI at age 10. Results: In each group, pattern 1 was characterized by its own cluster of food groups. Low: water/tea, savory snacks, sugar, low-fat meat, and fruits; middle: water/tea, low-fat cheese, fish, low-fat dairy, fruit drink, low-fat meat, and eggs; and high: low-fat cheese, fruits, whole-grain breakfast products, and low-fat and processed meat. Additionally, in each group, pattern 1 was positively associated with BMI z-scores at age 10 (low: β ≤ 0.43 [95% CI ≤ 0.21; 0.66], p < 0.001, middle: β ≤ 0.23 [0.09; 0.36], p ≤ 0.001, and high: β ≤ 0.24 [0.18; 0.30], p < 0.001). Conclusions: The dietary patterns stratified by the level of maternal education are characterized by different food groups. But in all the groups, pattern 1 is positively associated with BMI at age 10. [ABSTRACT FROM AUTHOR]

Abstract Background Low back pain (LBP) is a common health problem in workers that contributes to work disability and reduces quality of life. However, studies examining vulnerable groups in relation to sociodemographic differences in LBP remain scarce. Therefore, the current study investigates which sociodemographic groups of workers are most affected by LBP. Methods Data from the 2018 BIBB/BAuA employment survey were used (N = 16252). Age, education, occupational group, income, working hours, atypical working time, relationship status, and having children were used as sociodemographic predictors. Gender-stratified logistic regression analyses and intersectional classification tree analyses were conducted. Results A higher prevalence of LBP was observed for women compared to men. Significant differences in LBP emerged for age, working hours, atypical working time, occupational group and education, with some gender differences in the importance of predictors: Age was a significant predictor mostly in men as compared to women, atypical working hours had a slightly greater effect in women, whereas differences in LBP according to the occupational group were more pronounced for men. Vulnerable groups were found to be women who work in occupations other than professionals or managers, work atypical hours and have an intermediate or low educational level as well as men who work as skilled agricultural workers, craft workers, machine operators, or elementary occupations and are between 35 and 64 years old. Conclusions Thus, workers with certain occupations and lower levels of education, middle-aged men and women with unfavourable working time characteristics are most affected by low back pain. These groups should be focused on to potentially increase healthy working life and prevent work disability.

Abstract Background Diagnosis of alcohol use disorder (AUD) in primary care is critical for increasing access to alcohol treatment. However, AUD is underdiagnosed and may be inequitably diagnosed due to societal structures that determine access to resources (e.g., structural racism that limits opportunities for some groups and influences interpersonal interactions in and beyond health care). This study described patterns of provider-documented AUD in primary care across intersections of race, ethnicity, sex, and community-level socioeconomic status (SES). Methods This cross-sectional study used EHR data from a regional healthcare system with 35 primary care clinics that included adult patients who completed alcohol screenings between 3/1/2015 and 9/30/2020. The prevalence of provider-documented AUD in primary care based on International Classification of Diseases-9 (ICD-9) and ICD-10 diagnoses was compared across intersections of race, ethnicity, sex, and community-level SES. Results Among 439,375 patients, 6.6% were Latine, 11.0% Asian, 5.4% Black, 1.3% Native Hawaiian/Pacific Islander (NH/PI), 1.5% American Indian/Alaska Native (AI/AN), and 74.2% White, and 58.3% women. The overall prevalence of provider-documented AUD was 1.0% and varied across intersecting identities. Among women, the prevalence was highest for AI/AN women with middle SES, 1.5% (95% CI 1.0–2.3), and lowest for Asian women with middle SES, 0.1% (95% CI 0.1–0.2). Among men, the prevalence was highest for AI/AN men with high and middle SES, 2.0% (95% CI 1.1–3.4) and 2.0% (95% CI 1.2–3.2), respectively, and lowest for Asian men with high SES, 0.5% (95% CI 0.3–0.7). Black and Latine patients tended to have a lower prevalence of AUD than White patients, across all intersections of sex and SES except for Black women with high SES. There were no consistent patterns of the prevalence of AUD diagnosis that emerged across SES. Conclusion The prevalence of provider-documented AUD in primary care was highest in AI/AN men and women and lowest in Asian men and women. Findings of lower prevalence of provider-documented AUD in Black and Hispanic than White patients across most intersections of sex and SES differed from prior studies. Findings may suggest that differences in access to resources, which vary in effects across these identity characteristics and lived experiences, influence the diagnosis of AUD in clinical care.

Abstract Our objectives were to ascertain the following: (1) the prevalence and socioeconomic distribution of hypertension (HTN), undiagnosed for HTN, and untreated cases of HTN‐diagnosed individuals; (2) the relationship between SES and the prevalence of HTN, undiagnosed for HTN, and untreated for HTN; and (3) whether sex moderate this association. Data from the 2017–18 Bangladesh Demographic Health Survey were used. 11,776 participants who were 18 years of age or older responded to our analysis. The age‐adjusted prevalence of HTN, undiagnosed for HTN, and untreated cases was 25.1%, 57.2%, and 12.3%. Compared to females, males were less likely to have HTN but more likely to have undiagnosed HTN. People in the rich SES groups had a higher odd of (adjusted odds ratio [aoR] 1.25; 95% confidence interval [CI] 1.08–3.45) of having HTN compared to those in the poor SES group. When compared to individuals in the poor SES group, those in the rich SES group had lower odds of undiagnosed (aoR 0.57; 95% CI 0.44–0.74) and untreated (aoR 0.56; 95% CI 0.31–0.98) for HTN. Sex moderated the association between SES and HTN prevalence, which showed that men from rich SES were more likely to suffer from HTN than men from poor SES. According to this study, the government and other pertinent stakeholders should concentrate more on developing suitable policy measures to reduce the risk of HTN, particularly for men in rich socioeconomic groups. They should also concentrate on screening and diagnosing HTN in socioeconomically disadvantaged populations, regardless of sex.

Abstract Background Osteosarcoma (OS) is one of the most common primary malignant tumors of bone in children, which develops from osteoblasts and typically occurs during the rapid growth phase of the bone. Recently, Super-Enhancers(SEs)have been reported to play a crucial role in osteosarcoma growth and metastasis. Therefore, there is an urgent need to identify specific targeted inhibitors of SEs to assist clinical therapy. This study aimed to elucidate the role of BRD4 inhibitor GNE-987 targeting SEs in OS and preliminarily explore its mechanism. Methods We evaluated changes in osteosarcoma cells following treatment with a BRD4 inhibitor GNE-987. We assessed the anti-tumor effect of GNE-987 in vitro and in vivo by Western blot, CCK8, flow cytometry detection, clone formation, xenograft tumor size measurements, and Ki67 immunohistochemical staining, and combined ChIP-seq with RNA-seq techniques to find its anti-tumor mechanism. Results In this study, we found that extremely low concentrations of GNE-987(2–10 nM) significantly reduced the proliferation and survival of OS cells by degrading BRD4. In addition, we found that GNE-987 markedly induced cell cycle arrest and apoptosis in OS cells. Further study indicated that VHL was critical for GNE-987 to exert its antitumor effect in OS cells. Consistent with in vitro results, GNE-987 administration significantly reduced tumor size in xenograft models with minimal toxicity, and partially degraded the BRD4 protein. KRT80 was identified through analysis of the RNA-seq and ChIP-seq data. U2OS HiC analysis suggested a higher frequency of chromatin interactions near the KRT80 binding site. The enrichment of H3K27ac modification at KRT80 was significantly reduced after GNE-987 treatment. KRT80 was identified as playing an important role in OS occurrence and development. Conclusions This research revealed that GNE-987 selectively degraded BRD4 and disrupted the transcriptional regulation of oncogenes in OS. GNE-987 has the potential to affect KRT80 against OS.

Introduction: Previous research has uncovered various inequalities for immigrant students in education systems worldwide. Yet, the degree to which diverse background factors, such as socio-economic status and prior educational trajectory, contribute to these educational disadvantages remains uncertain. Methods: Using data from the Flemish administrative database (2009-2019) on 48,340 mainstream students and 1,022 Newly Arrived Migrant Students (NAMS) across 685 schools, this study examines NAMS' passing and dropout rates in Flemish secondary education in comparison to the outcomes of their peers without a recentmigration background. Data included demographic background variables, school variables, and indicators of educational outcomes. Results: A cross-classified multilevel regression analysis showed that, after controlling for background variables, NAMS still show higher probabilities of failing a year and of dropping out. Moreover, the impact of SES is stronger for native students than for NAMS. Discussion: These results suggest the existence of a migrant background effect disadvantaging NAMS in Flemish secondary education. [ABSTRACT FROM AUTHOR]

Background: The annual incidence of sudden cardiac death is over 300,000 in the United States (US). Historically, inpatient implantation of secondary prevention implantable cardioverter defibrillator (ICD) has been variable and subject to healthcare disparities. Objective: To evaluate contemporary practice trends of inpatient secondary prevention ICD implants within the US on the basis of race, sex, and socioeconomic status (SES). Methods: The study is a retrospective analysis of the National Inpatient Sample from 2016 to 2020 of adult discharges with a primary diagnosis of ventricular tachycardia (VT), ventricular flutter, and fibrillation (VF). Adjusted ICD implantation rates based on race, sex, and SES and associated temporal trends were calculated using multivariate regression. Results: A total of 193,600 primary VT/VF discharges in the NIS were included in the cohort, of which 57,895 (29.9%) had ICD placement. There was a significant racial and ethnic disparity in ICD placement for Black, Hispanic, Asian, and Native American patients as compared to White patients; adjusted odds ratio (aOR): 0.86 [p <.01], 0.90 [p =.03], 0.81[p <.01], 0.45 [p <.01], respectively. Female patients were also less likely to receive an ICD compared to male patients (aOR: 0.75, p <.01). Disparities in ICD placement remained stable over the study period (ptrend ≥.05 in all races, both sexes and income categories). Conclusion: Racial, sex, and SES disparities persisted for secondary prevention ICD implants in the US. An investigation into contributing factors and subsequent approaches are needed to address the modifiable causes of disparities in ICD implantation as these trends have not improved compared to historic data. [ABSTRACT FROM AUTHOR]

Summary: The effect of deprivation on total bone health status has not been well defined. We examined the relationship between socioeconomic deprivation and poor bone health and falls and we found a significant association. The finding could be beneficial for current public health strategies to minimise disparities in bone health. Purpose: Socioeconomic deprivation is associated with many illnesses including increased fracture incidence in older people. However, the effect of deprivation on total bone health status has not been well defined. To examine the relationship between socioeconomic deprivation and poor bone health and falls, we conducted a cross-sectional study using baseline measures from the United Kingdom (UK) Biobank cohort comprising 502,682 participants aged 40–69 years at recruitment during 2006–2010. Method: We examined four outcomes: 1) low bone mineral density/osteopenia, 2) fall in last year, 3) fracture in the last five years, and 4) fracture from a simple fall in the last five years. To measure socioeconomic deprivation, we used the Townsend index of the participant's residential postcode. Results: At baseline, 29% of participants had low bone density (T-score of heel < -1 standard deviation), 20% reported a fall in the previous year, and 10% reported a fracture in the previous five years. Among participants experiencing a fracture, 60% reported the cause as a simple fall. In the multivariable logistic regression model after controlling for other covariates, the odds of a fall, fracture in the last five years, fractures from simple fall, and osteopenia were respectively 1.46 times (95% confidence interval [CI] 1.42–1.49), 1.26 times (95% CI 1.22–1.30), 1.31 times (95% CI 1.26–1.36) and 1.16 times (95% CI 1.13–1.19) higher for the most deprived compared with the least deprived quantile. Conclusion: Socioeconomic deprivation was significantly associated with poor bone health and falls. This research could be beneficial to minimise social disparities in bone health. [ABSTRACT FROM AUTHOR]

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Parents can have a significant impact on student progress, but it is unclear whether generally influential forms of parental involvement can be identified or if they have a differential impact. Our research focuses on the impact of different forms of parental involvement (at-home and in-school involvement) on primary and high school students' academic performance, and we also examine the differences between low- and high-status families. Our quantitative research analyzed data from all students that were in Grade 6 and Grade 10 in Hungary in 2019, and we conducted analysis using the Hungarian National Competency Assessment database (n = 183.366). We examined how parental involvement affects children's mathematics and reading achievements. The results of our research were as follows: (1) Parental involvement type impacts student achievement. Home-based PI has a negative effect, while teacher–parent conferences and discussing school events have a positive effect. (2) The link between parental involvement and student achievement is weaker for higher-status families compared to lower-status families. Based on our results, the generalizability of the positive impact of parental involvement can be questioned because not all forms of it have a favorable effect on student achievement. [ABSTRACT FROM AUTHOR]

An increased interest in the resilience of complex socio-ecological and socio-technical systems has led to a variety of metrics being proposed. An overview of these metrics and their underlying concepts would support identifying useful metrics for applications in science and engineering. This study undertakes a scoping review of resilience metrics for systems straddling the societal, ecological, and technical domains to determine how resilience has been measured, the conceptual differences between the proposed approaches, and how they align with the domains of their case studies. We find that a wide variety of resilience metrics have been proposed in the literature. Conceptually, ten different quantification approaches were identified. Four different disturbance types were observed, including sudden, continuous, multiple, and abruptly ending disturbances. Surprisingly, there is no strong pattern regarding socio-ecological systems being studied using the "ecological resilience" concept and socio-technical systems being studied using the "engineering resilience" concept. As a result, we recommend that researchers use multiple resilience metrics in the same study, ideally following different conceptual approaches, and compare the resulting insights. Furthermore, the used metrics should be mathematically defined, the included variables explained and their units provided, and the chosen functional form justified. [ABSTRACT FROM AUTHOR]

Understanding the psychological antecedents of socioeconomic status (SES) on pro-environmental behavior is crucial for effectively encouraging individuals from different socioeconomic backgrounds to address environmental issues. Previous research has separately examined the influence of SES and social observation on pro-environmental behavior. However, little is known about whether social observation moderates the influence of SES on proenvironmental behavior, and the underlying neurophysiological mechanisms remain uncharacterized. Using event-related potential (ERPs), we adopted the green purchase paradigm and manipulated subjective SES, to examine whether the influence of SES on pro-environmental behavior is moderated by social observation. The behavioral results revealed that individuals of high SES tended to purchase more eco-friendly products under the observable condition than those in the non-observable condition. The ERP results revealed that participants with high SES exhibited more negative N2 and N400 amplitude during environmental decisions in the non-observable condition than in the observable condition, indicating that high SES individuals experience less cognitive conflict during environmental decisions, which may reflect the attenuated cost--benefit trade-off due to reputational incentives in the presence of observers. Additionally, individuals with high SES exhibited greater reputational motivation when observed, as indicated by larger P3 amplitude. However, these differences were not observed among individuals with low SES. These findings suggest that SES is associated with distinct psychological and behavioral differences in pro-environmental behavior, moderated by social observation, evident across both the early and later stages of environmental decisions in the brain. [ABSTRACT FROM AUTHOR]

Background: Osteosarcoma (OS) is one of the most common primary malignant tumors of bone in children, which develops from osteoblasts and typically occurs during the rapid growth phase of the bone. Recently, Super-Enhancers(SEs)have been reported to play a crucial role in osteosarcoma growth and metastasis. Therefore, there is an urgent need to identify specific targeted inhibitors of SEs to assist clinical therapy. This study aimed to elucidate the role of BRD4 inhibitor GNE-987 targeting SEs in OS and preliminarily explore its mechanism. Methods: We evaluated changes in osteosarcoma cells following treatment with a BRD4 inhibitor GNE-987. We assessed the anti-tumor effect of GNE-987 in vitro and in vivo by Western blot, CCK8, flow cytometry detection, clone formation, xenograft tumor size measurements, and Ki67 immunohistochemical staining, and combined ChIP-seq with RNA-seq techniques to find its anti-tumor mechanism. Results: In this study, we found that extremely low concentrations of GNE-987(2–10 nM) significantly reduced the proliferation and survival of OS cells by degrading BRD4. In addition, we found that GNE-987 markedly induced cell cycle arrest and apoptosis in OS cells. Further study indicated that VHL was critical for GNE-987 to exert its antitumor effect in OS cells. Consistent with in vitro results, GNE-987 administration significantly reduced tumor size in xenograft models with minimal toxicity, and partially degraded the BRD4 protein. KRT80 was identified through analysis of the RNA-seq and ChIP-seq data. U2OS HiC analysis suggested a higher frequency of chromatin interactions near the KRT80 binding site. The enrichment of H3K27ac modification at KRT80 was significantly reduced after GNE-987 treatment. KRT80 was identified as playing an important role in OS occurrence and development. Conclusions: This research revealed that GNE-987 selectively degraded BRD4 and disrupted the transcriptional regulation of oncogenes in OS. GNE-987 has the potential to affect KRT80 against OS. [ABSTRACT FROM AUTHOR]

Our objectives were to ascertain the following: (1) the prevalence and socioeconomic distribution of hypertension (HTN), undiagnosed for HTN, and untreated cases of HTN‐diagnosed individuals; (2) the relationship between SES and the prevalence of HTN, undiagnosed for HTN, and untreated for HTN; and (3) whether sex moderate this association. Data from the 2017–18 Bangladesh Demographic Health Survey were used. 11,776 participants who were 18 years of age or older responded to our analysis. The age‐adjusted prevalence of HTN, undiagnosed for HTN, and untreated cases was 25.1%, 57.2%, and 12.3%. Compared to females, males were less likely to have HTN but more likely to have undiagnosed HTN. People in the rich SES groups had a higher odd of (adjusted odds ratio [aoR] 1.25; 95% confidence interval [CI] 1.08–3.45) of having HTN compared to those in the poor SES group. When compared to individuals in the poor SES group, those in the rich SES group had lower odds of undiagnosed (aoR 0.57; 95% CI 0.44–0.74) and untreated (aoR 0.56; 95% CI 0.31–0.98) for HTN. Sex moderated the association between SES and HTN prevalence, which showed that men from rich SES were more likely to suffer from HTN than men from poor SES. According to this study, the government and other pertinent stakeholders should concentrate more on developing suitable policy measures to reduce the risk of HTN, particularly for men in rich socioeconomic groups. They should also concentrate on screening and diagnosing HTN in socioeconomically disadvantaged populations, regardless of sex. [ABSTRACT FROM AUTHOR]

The aim of the article was to analyze the impact of outliers on the accuracy of intermittent demand forecasting. The hypothesis was verified that eliminating the influence of outliers leads to more accurate forecasts. A data set containing monthly sales time series of over 12 000 products was analyzed. Three outliers rejection strategies were analyzed (replacing outliers, replacing extreme values, isolation forest). Intermittent demand forecasts were determined using the Croston, SBA, TSB and SES methods, with optimization of smoothing constants and initial values. The accuracy of the forecasts was assessed from the point of view of the inventories value and the value of lost sales (lost demand). The conducted research shows that eliminating the influence of outliers significantly reduces the inventory level value, with only a slight increase in the value of lost sales. Eliminating the influence of outliers therefore provides an opportunity to improve the financial results of enterprises selling slow – moving products through a significant reduction in inventory levels. [ABSTRACT FROM AUTHOR]

Principal components analysis (PCA) and partial least squares (PLS) have been used for the construction of socioeconomic status (SES) indices to use as a predictor of the well-being status in targeted programs. Generally, these indicators are constructed as a linear combination of the first component. Due to the characteristics of the socioeconomic data, different extensions of PCA and PLS for non-metric variables have been proposed for these applications. In this paper, we compare the predictive performance of SES indices constructed using more than one component. Additionally, for the inclusion of non-metric variables, a variant of the normal mean coding is proposed that takes into account the multivariate nature of the variables, which we call multivariate normal mean coding (MNMC). Using simulations and real data, we found that PLS using MNMC as well as the classical dummy encoding method give the best predictive results with a more parsimonious SES index, both in regression and classification problems. [ABSTRACT FROM AUTHOR]

For students who perform inconsistently across subjects, teachers face challenges in formulating track recommendations, as their achievement will not point to one secondary school track. This issue may be more prominent for students from diverse backgrounds, given the achievement differences between specific subject domains within these groups. Therefore, we examined the impact of achievement inconsistency (by comparing standardised achievement levels between reading comprehension and mathematics within students) on students' track recommendations in the Dutch educational system (N = 4,248). Most student perform rather consistently. Approximately 20% of the students performed inconsistently (>1 SD difference between subjects). While the overall effect of inconsistency on track recommendations was small, achievement inconsistency primarily seemed to affect track recommendations when the inconsistency was moderate to large. Teachers formulated more "careful" (i.e., lower) track recommendations when the inconsistency was large. This effect was slightly more pronounced for higher-SES students, with no gender differences. [ABSTRACT FROM AUTHOR]

Aims: This study aims to investigate trends in four types of adolescent mental health problems; that is, psychosomatic symptoms, depressive symptoms, suicidal ideations, and suicide attempts 2004–2020. A second aim is to investigate the moderating roles of socioeconomic status and sex in these trends. Methods: The analysis is based on repeated cross-sectional data 2004–2020 among grade 9 students in secondary schools in a Swedish county. In total, data from 19,873 students were included in the analysis. We fitted linear and logistic regression equations and used survey-years' coefficients to estimate the trends. We also estimated the moderating effects of socioeconomic status and sex using interactions between survey year and socioeconomic status and sex, respectively. Results: The trends in all mental health problems declined over time. Through its interaction with survey year, socioeconomic status moderated the trends; psychosomatic symptoms (B = −0.115, P <0.001), depressive symptoms (B = −0.084, P <0.001) and suicidal ideations (odds ratio 0.953, confidence interval 0.924–0.983) significantly declined over time among those with high socioeconomic status. However, socioeconomic status did not have an association with the trend in suicide attempts. Interaction between sex and year of survey was associated with significant decreasing trends in depressive symptoms and suicidal ideations only among girls. Conclusions: Adolescent mental health problems have decreased over time, but only for adolescents with high socioeconomic status, or only in depressive symptoms and suicidal ideations for girls. The results shed light on the growing inequalities in health outcomes across levels of socioeconomic status. [ABSTRACT FROM AUTHOR]

STUDY OBJECTIVES: To examine the association of self-identified race with sleep quality in heavy smokers. METHODS: We studied baseline data from 1965 non-Hispanic White and 462 African American participants from SPIROMICS with ≥ 20 pack-years smoking history. We first examined the Pittsburgh Sleep Quality Indexs (PSQI) internal consistency and item-total correlation in a population with chronic obstructive pulmonary disease. We then used staged multivariable regression to investigate the association of race and sleep quality as measured by the PSQI) The first model included demographics, the second added measures of health status, and the third, indicators of socioeconomic status. We next explored the correlation between sleep quality with 6-minute walk distance and St. Georges Respiratory Questionnaire score as chronic obstructive pulmonary disease-relevant outcomes. We tested for interactions between self-identified race and the most important determinants of sleep quality in our conceptual model. RESULTS: We found that the PSQI had good internal consistency and item-total correlation in our study population of heavy smokers with and without chronic obstructive pulmonary disease. African American race was associated with increased PSQI in univariable analysis and after adjustment for demographics, health status, and socioenvironmental exposures (P = .02; 0.44 95%CI: .06 to .83). Increased PSQI was associated with higher postbronchodilator forced expiratory volume in 1 second and lower household income, higher depressive symptoms, and female sex. We identified an interaction wherein depressive symptoms had a greater impact on PSQI score for non-Hispanic White than African American participants (P for interaction = .01). CONCLUSIONS: In heavy smokers, self-reported African American race is independently associated with worse sleep quality. CLINICAL TRIAL REGISTRATION: Registry: ClinicalTrials.gov; Name: Study of COPD Subgroups and Biomarkers (SPIROMICS); URL: https://clinicaltrials.gov/ct2/show/NCT01969344; Identifier: NCT01969344. CITATION: Baugh AD, Acho M, Arhin A, et al. African American race is associated with worse sleep quality in heavy smokers. J Clin Sleep Med. 2023;19(8):1523-1532.

Children’s socioeconomic status (SES) is related to patterns of intrinsic resting-state brain function that subserve relevant cognitive processes over the course of development. Although infant research has demonstrated the association between children’s environments, cognitive outcomes, and resting-state electroencephalography (rsEEG), it remains unknown how these aspects of their environment, tied to SES, impact neural and cognitive development throughout the school years. To address this gap, we applied a multivariate pattern analysis (MVPA) to rsEEG data to identify which neural frequencies at rest are differentially associated with unique aspects of socioeconomic status (SES; income and maternal education) and cognitive (vocabulary, working memory) outcomes among school-aged children (8–15 years). We find that the alpha frequency is associated with both income and maternal education, while lower gamma and theta fluctuations are tied to dissociable aspects of SES and cognitive outcomes. Specifically, changes in the gamma frequency are predictive of both maternal education and vocabulary outcome, while changes in the theta frequency are related to both income and working memory ability. The current findings extend our understanding of unique pathways by which SES influences cognitive and neural development in school-aged children.

Since its beginning in 2000, the OECD's Program for International Student Assessment (PISA) declared the promotion of educational equity as one of its core values and goals. For more than 2 decades, OECD and independent researchers have been taking advantage of the PISA datasets, using them to measure, explore and monitor the changes in educational equity, which has resulted in a comprehensive body of literature. This review offers a summary of official reports and independent studies regarding the change in socioeconomic equity in different countries based on PISA data analysis. We explore four types of educational equity (Equality of Opportunity, Equality of Outcome, Segregation, and Resilience) and summarize the results of the reviewed studies based on their method, geography, and reported trend of change.

IntroductionOlder adults benefit from social connections as it aids in their adjustment to the physical and psychological changes that come with aging, thereby improving their health, well-being, and overall quality of life.MethodsThis study utilizes data from the 2020 China Health and Retirement Longitudinal Study (CHARLS) to investigate the influence of Socio-economic Status (SES) on the social activity levels of older persons and the disparities observed among demographic groups, employing the Heckman two-stage analysis and heterogeneity analysis.ResultsThe results indicate that SES has a significant positive impact on the social engagement of older adults, and this effect varies across different older groups, with women, married individuals living with a spouse, urban residents, those aged 70–79, and individuals with average health conditions.DiscussionTo effectively address the social needs of older adults, it is essential to prioritize integrating cohesive structural methods that improve social connections. Establishing solid and sustainable social support mechanisms and meeting the social needs of older adults across various SES and demographic groups are crucial in promoting active and healthy aging.

IntroductionRacial-ethnic disparities in COVID-19 vaccination are well documented. The extent to which racism, manifested at the individual and ZIP code levels, explains disparities in early vaccination uptake remains unclear.MethodsData from a statewide poll of California registered voters (N=10,256), conducted between April 29 and May 5, 2021, linked to area-level resource data, were analyzed. Weighted multivariable logistic regression models examined racial disparities in COVID-19 vaccination. Decomposition analyses quantified how much of the observed racial disparities in vaccination were explained by racial discrimination and social disadvantage (i.e., educational attainment, 2019 household income, and ZIP code social vulnerability).ResultsLatinx (64.6%) and Black (66.7%) adults were less likely to have at least 1 COVID-19 vaccine dose by April or May 2021 than White adults (74.7%). In adjusted analyses, Latinx (AOR=0.69, 95% CI=0.57, 0.84) and Black (AOR=0.51, 95% CI=0.37, 0.70) adults had a lower likelihood of being vaccinated than Whites. Social disadvantage accounted for 77.4% (p

Abstract Background Suicide poses a major public health challenge, claiming around 650 lives annually in Norway. There is limited understanding of mental healthcare utilization patterns preceding suicide, particularly relating to socioeconomic status (SES). This study analyzes mental health service use among Norwegian citizens aged 20–64 from 2009 to 2021, emphasizing disparities related to SES. Methods This is a population-wide registry-based study. We include mental health consultations with both primary and specialist healthcare services, and investigate patterns of service use regarding educational attainment, employment status and income and compare this to the population in general. All suicides in the period (N = 4731) are included in the study. The aim is to investigate potential discrepancies in service use the year and month preceding suicide, seeking to enhance targeted preventive interventions. Results Our results show significant variations in healthcare use for mental health problems the last year preceding suicide, according to the components of SES, for both men and women. Those with higher education utilize the mental healthcare services prior to suicide to a higher degree than men and women with high school education or less, whereas employed men and men with high income level have significantly lower mental healthcare usage prior to suicide both the last year and month compared to the non-employed men and men with low-income level. Employed women also had a lower mental healthcare usage, whereas the results regarding income are not significant for women. Conclusion Mental healthcare use prior to suicide varies across the SES components. Notably, the SES groups exhibit heterogeneity, with gendered patterns. Targeted interventions for low consultation rates among employed men, and men with high income and lower education are needed, while women, and men in at-risk groups, such as the non-employed and those with low income, demonstrate higher mental healthcare utilization, warranting comprehensive suicide prevention measures.

Abstract The effect of family socioeconomic status (SES) on academic achievement in literacy and numeracy has been extensively studied with educational inequalities already witnessed in preschoolers. This is presumably explained by the effect of family SES on cognitive and socioemotional abilities associated with academic achievement. Metacognition which refers to knowledge and regulation skills involving reflexivity about one's own cognitive processes is one of these abilities. However, most of the studies investigating the association between metacognition and academic achievement have focused on school-aged students and studies with younger students are only emerging. Meanwhile, the association between family SES and metacognition abilities has surprisingly received little attention regardless of participants’ age. The aim of this study was to explore the associations between family SES, metacognition, language and mathematical abilities in preschoolers aged 5 to 6. We provide the first evidence that the effect of family SES on preschoolers’ language and mathematical abilities is mediated by the effect of family SES on their metacognitive abilities. The implications for future research, education and policies aiming at reducing educational inequalities are discussed.

Abstract Background The positive association of health with education level and socioeconomic status (SES) is well-established. Two theoretical frameworks have been delineated to understand main mechanisms leading to socioeconomic health inequalities: social causation and health selection but how these work in adolescence is poorly known. We studied if adolescent health and health behaviours predict higher education and higher SES in adulthood and if family background and school performance in adolescence explain these associations. Methods Surveys on health and health behaviours were sent to representative samples of 12–18-year-old Finns in 1981–1997 every second year (response rate 77.8%, N = 55,682). The survey data were linked with the respondents’ and their parents’ socioeconomic data from the Finnish national registries. Both latent variables, namely, health (perceived health, health complaints, chronic disease), health-compromising behaviours (smoking status, drunkenness frequency), and family background (parents’ occupation-based SES, education, family type) and variables directly measuring health-enhancing behaviours (toothbrushing, physical activity) and school performance were used to predict higher education and higher occupation-based SES at age 34. Logistic regression analysis and structural equation models (SEM) were used. Results In logistic regression analyses, good health, health-enhancing behaviours, and lack of health-compromising behaviours were related to higher education and SES, also after controlling for family background and school performance. In the SEM analyses, good health, health-enhancing behaviours, and lack of health-compromising behaviours directly predicted higher SES and higher education, although the standardised coefficients were low (from 0.034 to 0.12). In all models, health, lack of health-compromising behaviours, and health-enhancing behaviours predicted school performance, which in turn, predicted the outcomes, suggesting indirect routes to these. Good socioeconomic prospects in terms of family background predicted good health, healthy behaviours, and good school performance in adolescence and higher SES and higher education in adulthood. Conclusion Health and health behaviours in adolescence predicted education and SES in adulthood. Even though the relationships were modest, they support the health selection hypotheses and emphasise the importance of adolescence for health inequalities during the life-course. Health and health behaviours were strongly associated with school performance and family background which together modified the paths from health and health behaviours to the outcomes.

This research is about the semantic equivalent of sounds in the Arabic language, which is a fundamental component in the formation of utterances. In classical language studies, syntaxists tried to ground semantics at the level of words and sentences. In the periods when the written form of the language was respected, letters were regarded as the basic carrier elements of words and meanings. However, sounds rather than letters, which are products of written form, are the basic components that make up the existence of language. Therefore, the oldest form of a language is its oral form. Sounds can be classified into vocal and consonant categories. This study aims to reveal the nature and importance of vocals in Arabic in terms of meaning. It is a generally accepted idea that vocals have a semantic influence. However, it is a fundamental issue that needs to be investigated in what respect and at what level the vocals affect the meaning. However, it is a fundamental issue that needs to be investigated in what respect and at what level the vocals affect the meaning. The determination that the relationship between sound and meaning exists at a significant level will provide to reach important presumptions about the origin of language and its words. This study concerns Sāmı̄languages in particular and all languages in general, in terms of the results to be achieved. The main hypothesis of the research is to reach meaningful conclusions about the semantic nature of vocals, based on the ideas pointed out by classical period linguists. In this context, the theories of names such as Ḫalīl b. Aḥmad, Sībawayhi, Ḳutrub, İbn Cinnī regarding voice and especially vocals are discussed holistically. The research is based on two themes. These are morphology and syntax. Arabic morphology has sīġas derived by the istiqaq method. Classical linguists have identified ready-made patterns to which words could potentially belong. Changes in these patterns occur through vocals and consonants. In some cases, it is only the vocals that determine the meaning. This issue, which concerns phoneme theory, essentially reflects the characteristics of Arabic language methodology. Because the sound changes between forms essentially involve a mechanical structure. For example, the difference between the fāʿil and fāʿale patterns stems from only a single vocal. However, both forms cause different roles and actions, especially in terms of syntax. Another aspect of the issue is the amil theory. The ʿāmil, one of the most basic methodologies of the Arabic language, determines the meaning on the syntax level. This event, which is specific to iʿrāb ḥarakāt, is related to vocals. Vocals take on various roles with three basic ḥarakāt: ḍamme, fetḥa, and kesra. Ḍamme is thought to be the strongest of all vocals. The elements that are affected by the outcome of the action are fetḥa, and the elements that take on the explanatory role are kasra, the weakest vocal. Apart from all these, sound-related events such as the bilateralism theory, the principle of convenience, and sound symbolism contain information that vocals can have special meanings. In fact, this part of the issue concerns the ontological aspect of language. Hypotheses regarding the emergence of language should prioritize the role of sounds. Similar research can be conducted specifically for different cultures and civilizations. The second important part of the issue is related to the pedagogical aspect of the language. Another goal of this study is to re-evaluate basic topics such as iʿrāb in Arabic grammar from a sound-centered perspective and present them to the target audience. [ABSTRACT FROM AUTHOR]

Developmental changes in functional neural networks are sensitive to environmental influences. This EEG study investigated how infant brain responses relate to the social context that their families live in. Event-related potentials of 255 healthy, awake infants between six and fourteen months were measured during a passive auditory oddball paradigm. Infants were presented with 200 standard tones and 48 randomly distributed deviants. All infants are part of a longitudinal study focusing on families with socioeconomic and/or cultural challenges (Bremen Initiative to Foster Early Childhood Development; BRISE; Germany). As part of their familial socioeconomic status (SES), parental level of education and infant's migration background were assessed with questionnaires. For 30.6% of the infants both parents had a low level of education (≤10 years of schooling) and for 43.1% of the infants at least one parent was born abroad. The N2–P3a complex is associated with unintentional directing of attention to deviant stimuli and was analysed in frontocentral brain regions. Age was utilised as a control variable. Our results show that tone deviations in infants trigger an immature N2–P3a complex. Contrary to studies with older children or adults, the N2 amplitude was more positive for deviants than for standards. This may be related to an immature superposition of the N2 with the P3a. For infants whose parents had no high-school degree and were born abroad, this tendency was increased, indicating that facing multiple challenges as a young family impacts on the infant's early neural development. As such, attending to unexpected stimulus changes may be important for early learning processes. Variations of the infant N2–P3a complex may, thus, relate to early changes in attentional capacity and learning experiences due to familial challenges. This points towards the importance of early prevention programs. [ABSTRACT FROM AUTHOR]

This study aimed to estimate the prevalence of children aged 0–19 years who have a parent with a history of heart disease and investigate their sociodemographic characteristics. A national register-based study. From the Danish Fertility Register and the Danish National Patient Register information on children of parents with ischemic heart disease, arrhythmia, heart failure and heart valve disease in the period 1981–2018 were obtained. Statistical analyses including descriptive statistics, logistic and linear regression were used to illuminate associations between parental heart disease and sociodemographic characteristics. The study population consisted of 142,480 children aged 0–19 years with at least one parent diagnosed with heart disease, corresponding to every 9th child in Denmark in 2018. The number increased from 4.5% in 2002 to 11.1% in 2018. In the study population most had a father with heart disease (57.8%) and 4.6% had two parents with heart disease. Parents with heart disease had significantly higher odds of being out of work (OR 1.68, 95% CI 1.64; 1.72), in a single-parent household (OR 1.09, 95% CI 1.07; 1.11), divorced or widowed (OR: 1.10, 95% CI 1.08; 1.12), having a lower educational level (OR 1.35, 95% CI 1.33; 1.37), and a lower family income (−42,410 DKR, 95% CI -50,306; −34,514, P < 0.0001) compared to those without heart disease. Children affected by parental heart disease comprise a substantial part of the Danish population. These have significantly different sociodemographic characteristics than children in families without parental heart disease, which might affect social heritage and parental capacity. [ABSTRACT FROM AUTHOR]

Previous studies have found that adolescents and their parents may hold discrepant views about educational aspirations. However, little is known about how these discrepancies affect adolescents' internalizing problems and the moderating effect of SES on the relation between (in)congruence of parent–child educational aspirations and adolescents' internalizing problems. Therefore, this study explored the relation between (in)congruence of parent–child educational aspirations and adolescents' internalizing problems, and further tested the moderating role of SES. Based on two-wave survey data collected from a nationally representative sample of 8194 parent–child dyads in China (51.3 % boys, mean age = 13.58 years), multilevel polynomial regression and response surface analysis were performed to investigate the hypotheses. The results found that (1) internalizing problems were minimal when the two educational aspiration variables were congruent, (2) internalizing problems were the highest when the discrepancy between child educational and parental educational aspirations was largest, and (3) SES moderated the relation between (in)congruence in educational aspirations and adolescents' internalizing problems. The study's results not only comprehensively and intuitively reveal the influence of parents' and children's educational aspirations on adolescents' internalizing problems, but also provide targeted guidance and suggestions regarding parenting practices for families from diverse SES backgrounds. • Adolescents with congruence of educational aspirations with their parents have the lowest level of internalizing problems. • Adolescents' internalizing problems will increase as the discrepancies in educational aspirations increase. • Adolescents' SES moderates the (in)congruent effects educational aspirations on adolescents' internalizing problems. [ABSTRACT FROM AUTHOR]

Research has shown that some students who underperform in mathematics overestimate their performance, while others who excel in mathematics underestimate it. Looking at this mismatch of performance and confidence judgement—the Dunning–Kruger effect (DKE)—the current study investigates how well students' confidence judgement and item-specific mathematics competence relate with each other and whether such a relationship differs across six European countries (i.e., Norway, Sweden, Finland, Estonia, Serbia and Portugal). We also examine whether perceived competence, mathematics identity, gender, socioeconomic status and immigration background predict this mismatch and whether these demographic factors function differently between the examined countries. The results show that the DKE could be found across grades three and four in all six countries. However, there are country-specific patterns regarding the relationship between performance, mathematics identity and perceived competence; the DKE; and how different demographic variables predict its occurrences in particular subpopulations. [ABSTRACT FROM AUTHOR]

This systematic review and meta-analysis aimed to investigate the impact of COVID19 lockdown on the anthropometric and glycaemic outcomes of adults with type 2 diabetes mellitus (T2DM) and assess whether socioeconomic status (SES) was relevant to these changes. A search of three databases was conducted. Meta-analyses using random effects models were undertaken to combine anthropometric and glycaemic measures pre- and post-confinement. Subgroup analyses according to SES were also conducted. This systematic review of 19 articles demonstrated that prolonged pandemic-related confinement is associated with a deterioration in both anthropometric and glycaemic outcomes among adults with T2DM. Furthermore, SES was found to be relevant to these changes. Specifically, BMI (kg/m2) showed an increase in mean difference of 0.72 (95% CI; 0.13, 1.31; p<0.05) between pre and post lockdown cohorts. High income countries displayed a greater increase in BMI compared to their lower middle-income counterparts. Regarding, fasting blood glucose (FBG), a statistically significant difference was observed in the upper middle-income group (mean difference: 5.10; 95% CI: 2.92, 7.27), and high-income group (mean difference: 6.03; 95% CI: 0.04, 12.02). There were no significant changes to weight, waist circumference, or HbA1C over the lockdown period. Our findings suggest adults with T2DM may have received less effective care over the lockdown period, particularly in high income countries. Clinics and care providers may need to adopt more intensive contact and treatment plans in the post lockdown period to prevent lasting impacts on disease progression and metabolic sequelae. • Prolonged COVID-19 lockdown is associated with deterioration in anthropometric and glycaemic outcomes in adults with T2DM. • High SES is associated with poorer anthropometric and glycaemic outcomes following prolonged confinement. • Adults with T2DM may have received less effective care over the lockdown period, particularly in high income countries. [ABSTRACT FROM AUTHOR]

Background: Suicide poses a major public health challenge, claiming around 650 lives annually in Norway. There is limited understanding of mental healthcare utilization patterns preceding suicide, particularly relating to socioeconomic status (SES). This study analyzes mental health service use among Norwegian citizens aged 20–64 from 2009 to 2021, emphasizing disparities related to SES. Methods: This is a population-wide registry-based study. We include mental health consultations with both primary and specialist healthcare services, and investigate patterns of service use regarding educational attainment, employment status and income and compare this to the population in general. All suicides in the period (N = 4731) are included in the study. The aim is to investigate potential discrepancies in service use the year and month preceding suicide, seeking to enhance targeted preventive interventions. Results: Our results show significant variations in healthcare use for mental health problems the last year preceding suicide, according to the components of SES, for both men and women. Those with higher education utilize the mental healthcare services prior to suicide to a higher degree than men and women with high school education or less, whereas employed men and men with high income level have significantly lower mental healthcare usage prior to suicide both the last year and month compared to the non-employed men and men with low-income level. Employed women also had a lower mental healthcare usage, whereas the results regarding income are not significant for women. Conclusion: Mental healthcare use prior to suicide varies across the SES components. Notably, the SES groups exhibit heterogeneity, with gendered patterns. Targeted interventions for low consultation rates among employed men, and men with high income and lower education are needed, while women, and men in at-risk groups, such as the non-employed and those with low income, demonstrate higher mental healthcare utilization, warranting comprehensive suicide prevention measures. [ABSTRACT FROM AUTHOR]

CLIL (Content and Language Integrated Learning) research has thrived recently. Yet, while more and more is learnt about the impact of CLIL on motivation, proficiency, and content learning, few investigations examine how CLIL influences students of different socio-economic status (SES) and why. The recent large-scale English Impact study conducted in the Madrid region showed that CLIL has a potential to limit the influence of SES on students' language learning motivation and proficiency. Yet being solely quantitative, it did not probe into the reasons behind such a result. This mixed-methods study aims to uncover such reasons. 138 teachers from different schools in the Madrid region filled in the TALIS questionnaire (OECD 2013. TALIS Teacher Questionnaire. ) and further 20 teachers were interviewed. Whereas no significant differences between teachers from CLIL and non-CLIL schools were identified through the questionnaire, the interviews revealed that teachers from bilingual schools adapted their teaching methodology to best suit their students' needs, and were more willing to take risks than their counterparts in non-bilingual schools. [ABSTRACT FROM AUTHOR]

Efficacy beliefs are important determinants of human behavior. In the context of social cognitive theory, the perception of collective efficacy is closely related to the individual perception of self-efficacy, which is influenced by socio-structural factors such as socioeconomic status (SES). Surprisingly, the relationship between these variables has received little attention in the literature on environmental issues. Within the framework of social cognitive theory, the aim of this study was to investigate whether SES has a direct effect on pro-environmental behavior and whether it has an indirect effect via perceptions of self-efficacy and collective efficacy, in relation to climate change mitigation behavior. An online cross-sectional study was conducted using a quota sample of 1075 participants (51.9% women) aged 18–79 years. Participants reported their SES using objective and subjective measures, perceptions of their own and collective efficacy in mitigating climate change, and the frequency of their pro-environmental behaviors. Structural equation modeling revealed that the model with serial mediation effects of self-efficacy and collective efficacy between SES (both objective and subjective) and pro-environmental behaviors showed a good model fit. As expected, both objective and subjective SES had no direct effect on pro-environmental behavior. Surprisingly, neither objective nor subjective SES had an indirect effect (via efficacy beliefs) on pro-environmental behavior. However, both self-efficacy and collective efficacy were associated with pro-environmental behavior. These findings have practical implications for the development of strategies aimed at enhancing pro-environmental behavior. [ABSTRACT FROM AUTHOR]

The 22q11.2 deletion syndrome (22q11.2DS) is associated with a heterogeneous neurocognitive phenotype, which includes psychiatric disorders. However, few studies have investigated the influence of socioeconomic variables on intellectual variability. The aim of this study was to investigate the cognitive profile of 25 patients, aged 7 to 32 years, with a typical ≈3 Mb 22q11.2 deletion, considering intellectual, adaptive, and neuropsychological functioning. Univariate linear regression analysis explored the influence of socioeconomic variables on intellectual quotient (IQ) and global adaptive behavior. Associations with relevant clinical conditions such as seizures, recurrent infections, and heart diseases were also considered. Results showed IQ scores ranging from 42 to 104. Communication, executive functions, attention, and visuoconstructive skills were the most impaired in the sample. The study found effects of access to quality education, family socioeconomic status (SES), and caregiver education level on IQ. Conversely, age at diagnosis and language delay were associated with outcomes in adaptive behavior. This characterization may be useful for better understanding the influence of social-environmental factors on the development of patients with 22q11.2 deletion syndrome, as well as for intervention processes aimed at improving their quality of life. [ABSTRACT FROM AUTHOR]

Social exclusion - in sports as well as in all other areas of life - is linked to low socioeconomic status, poverty, unemployment, and low educational attainment. This means that disadvantaged social groups are permanently trapped in a lifestyle lacking physical exercise. In a broader sense, social exclusion from sports activities affects a much wider social spectrum, including groups that suffer disadvantages based on gender, age, place of residence, or disability [Spaaij, R., Farquharson, K., & Marjoribanks, T. (2015). Sport and social inequalities. Sociology Compass, 9(5), 400-411. https://doi.org/10.1111/soc4.12254]. In Southern, Central, and Eastern Europe, a smaller fraction of society has the opportunity to be active regularly, while the majority are left out. Based on Bourdieu's theory on capital and habitus our paper aims to find out what demographic and socialisation factors, as well as how the socio-economic status and the student habitus play roles in student sport activity in five Central and Eastern European countries. Our analysis is based on the database of the questionnaire survey carried out among students in the examined region (PERSIST 2019, N = 2005). Our results show that although students with a higher social status pursue sport more regularly and are more likely to pursue a sport in clubs, gender, habitus, the parental sporting environment, and sporting friends are the main factors that play a positive role in their regular participation. [ABSTRACT FROM AUTHOR]