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18. Multimorbidität und erfolgreiches Altern: Ein Blick auf die Bevölkerung im Rahmen der KORA-Age-Studie

Author

Peters, A., Döring, A., Ladwig, K.-H., Meisinger, C., Linkohr, B., Autenrieth, C., Baumeister, S.E., Behr, J., Bergner, A., Bickel, H., Bidlingmaier, M., Dias, A., Emeny, R.T., Fischer, B., Grill, E., Gorzelniak, L., Hänsch, H., Heidbreder, S., Heier, M., Horsch, A., Huber, D., Huber, R.M., Jörres, R.A., Kääb, S., Karrasch, S., Kirchberger, I., Klug, G., Kranz, B., Kuch, B., Lacruz, M.E., Lang, O., Mielck, A., Nowak, D., Perz, S., Schneider, A., Schulz, H., Müller, M., Seidl, H., Strobl, R., Thorand, B., Wende, R., Weidenhammer, W., Zimmermann, A.-K., Wichmann, H.-E., and Holle, R.

Published
2011
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28. List of Contributors

Author

ABE, FUMIYOSHI, primary, ADDOLORATO, GIOVANNI, additional, ALDRED, PETER, additional, ALLER, R., additional, ALMEIDA, PAULO, additional, ÁLVAREZ, JESÚS-ROMÁN MARTÍNEZ, additional, AMERONGEN, A.V. NIEUW, additional, ANDERSEN, MOGENS L., additional, AOSHIMA, HITOSHI, additional, ARIMOTO-KOBAYASHI, SAKAE, additional, ASFAW, ALEMAYEHU, additional, AUSTIN, ERICA WEINTRAUB, additional, BACK, WERNER, additional, BAEK, SEUNG JOON, additional, BAER-DUBOWSKA, WANDA, additional, BARROS, AQUILES A., additional, BECKER, HANS, additional, BÉNÉDICTE, BAKAN, additional, BERWANGER, STEFANIE, additional, BLEICH, STEFAN, additional, BLUMBERG, JEFFREY B., additional, BOELENS, JERINA, additional, BOHR, GREGOR, additional, BRACKE, MARC, additional, BRAND, H.S., additional, BRUINS, M.L., additional, BUIATTI, STEFANO, additional, CATHARINO, RODRIGO R., additional, CERVERA, M. LUISA, additional, CHEN, CHUNG-YEN, additional, CHEN, QIAO QIAO, additional, CHEN, YUONNES, additional, COMI, GIUSEPPE, additional, CORTACERO-RAMÍREZ, SONIA, additional, DAENEN, L., additional, De COOMAN, L., additional, De LUIS, D.A., additional, De SCHUTTER, D.P., additional, DEINZER, MAX L., additional, DELVAUX, F., additional, DEMMEL, RALF, additional, DERDELINCKX, G., additional, DEY, ESTERA SZWAJCER, additional, DÍAZ-RUBIO, M.E., additional, DICKINSON, J. RICHARD, additional, DIDIER, MARION, additional, DIEL, FRIEDHELM, additional, DIEL, SUSANNE, additional, DILLER, REINHARD A., additional, DLAMINI, ZODWA, additional, DOBROWOLSKA-ZACHWIEJA, AGNIESZKA, additional, DUFOUR, JEAN-PIERRE, additional, EBERLIN, MARCOS N., additional, EFFENBERGER, KATHARINA E., additional, EYRES, GRAHAM, additional, FANTOZZI, PAOLO, additional, FEGREDO, JUSTIN A., additional, FEICK, PETER, additional, FERNÁNDEZ-GUTIÉRREZ, ALBERTO, additional, FERREIRA REQUIMTE, ISABEL M.P.L.V.O., additional, FERRULLI, ANNA, additional, FONTANA, MARTA, additional, FOX, GLEN P., additional, Da CRUZ FRANCISCO, JOSÉ, additional, FRANK, NORBERT, additional, FRANKE, ANDREAS, additional, FREEMAN BRI, GARY, additional, FRIAS, CORAZON, additional, FRÖLICH, SONJA, additional, FUCHS, DIETMAR, additional, GAMIAN, ANDRZEJ, additional, GARCÍA-FALCÓN, S., additional, GARRIGUES, SALVADOR, additional, GASBARRINI, ANTONIO, additional, GASBARRINI, GIOVANNI, additional, GERHÄUSER, CLARISSA, additional, GERLOFF, ANDREAS, additional, GHISELLI, ANDREA, additional, GIL, A.M., additional, GOÑI, I., additional, GORJANOVIĆ, STANISLAVA, additional, de la GUARDIA, MIGUEL, additional, GUERRA, N.P., additional, GUIDO, LUIS F., additional, GUPTA, SANJAY, additional, HELLBORG, LINDA, additional, HENZE, GÜNTER, additional, HERNÁNDEZ-ARTIGA, MARÍA PURIFICACIÓN, additional, HERNÁNDEZ-BORGES, JAVIER, additional, HERWALD, MARIA, additional, HILLEMACHER, THOMAS, additional, HOSSAIN, SHEIKH JULFIKAR, additional, HUGHES, PAUL, additional, HUST, STACEY J.T., additional, HUVAERE, KEVIN, additional, IACOMINO, GIUSEPPE, additional, IGNATOWICZ, EWA, additional, IKEDA, KATSUMI, additional, JANDERA, PAVEL, additional, JENETT-SIEMS, KRISTINA, additional, JUGDAOHSINGH, RAVIN, additional, KAWASAKI, MASATO, additional, KERR, WILLIAM C., additional, KHMELINSKII, IGOR, additional, KISO, YOSHINOBU, additional, KODA, HIROFUMI, additional, KOMAITIS, M., additional, KONDO, KEIJI, additional, KRAJKA-KUZNIAK, VIOLETTA, additional, KRATKY, ROBERTO, additional, KRUISSELBRINK, L. DARREN, additional, LAI, ALAN K.H., additional, LEDOCHOWSKI, M., additional, LEE, SEONG-HO, additional, LEGGIO, LORENZO, additional, LI, HUI-JING, additional, LIRDPRAPAMONGKOL, KRIENGSAK, additional, LITTLE, ALEX G., additional, LÓPEZ-MACÍAS, C., additional, LORET, SUZANNE, additional, LOUKOU, ZACHARENIA, additional, LOZANOV, VALENTIN, additional, LUST, SOFIE, additional, MABIALA-BABELA, JEAN ROBERT, additional, MANZANO, MARISA, additional, MARCONI, OMBRETTA, additional, MARQUES-VIDAL, PEDRO, additional, MARTIN, COLIN R., additional, MARTÍNEZ-CARBALLO, E., additional, MASSAMBA, ALPHONSE, additional, MAYER, HEIDI, additional, MBITA, ZUKILE, additional, Mc KINNEY, ADELE, additional, McCRAE, NIALL, additional, MENZ, GARRY, additional, MEYNELL, RACHEL, additional, MILLA, DOLORES BELLIDO, additional, MILLIGAN, STUART R., additional, MONTANARI, LUIGI, additional, MORALES, FRANCISCO J., additional, MORIWAKI, YUJI, additional, MUKAMAL, KENNETH J., additional, MURPHY, RENÉ J.L., additional, NANADOUM, MAOURA, additional, NARDINI, MIRELLA, additional, NATELLA, FAUSTA, additional, NAVARRO, SIMÓN, additional, NICOLAI, JENNIFER, additional, NOZAWA, HAJIME, additional, OFFNER, FRITZ, additional, PASTRANA-CASTRO, L.M., additional, PAULL, DOUGLAS E., additional, PAVSLER, ANDREA, additional, PEHL, C., additional, PÉREZ-JIMÉNEZ, JARA, additional, PINKLETON, BRUCE E., additional, PISKUR, JURE, additional, POHL, PAWEL, additional, POSSEMIERS, SAM, additional, POURQUIE, JACQUES, additional, POWELL, JONATHAN J., additional, PREEDY, VICTOR R., additional, PROESTOS, C., additional, PROKOP, ARAM, additional, RAINIERI, SANDRA, additional, RAJENDRAM, RAJKUMAR, additional, RAYBURN, BRITTANY B., additional, RAYBURN, WILLIAM F., additional, RIEPL, HERBERT M., additional, RODRIGUES, JOSÉ, additional, RODRIGUEZ-DELGADO, MIGUEL ÁNGEL, additional, ROSE, OLIVER, additional, ROWLAND, NEIL E., additional, RUSSO, GIAN LUIGI, additional, SAIKI, IKUO, additional, SAISON, D., additional, SAKUMA, SHUSO, additional, SAKURAI, HIROAKI, additional, SANDRA, PAT, additional, SAURA-CALIXTO, FULGENCIO, additional, SAWAYA, ALEXANDRA C.H.F., additional, SCACCINI, CRISTINA, additional, SCHENNACH, H., additional, SCHEWE, TANKRED, additional, SCHROECKSNADEL, K., additional, SCHUBERT, CAROLA, additional, SEGURA-CARRETERO, ANTONIO, additional, SEIDL, H., additional, SERRANO, JOSÉ, additional, SHIBAMOTO, TAKAYUKI, additional, SHUKLA, SANJEEV, additional, SIES, HELMUT, additional, SIKORSKA, EWA, additional, SIKORSKI, MAREK, additional, SIMAL-GÁNDARA, J., additional, SINGER, MANFRED V., additional, SOARES, EDUARDO V., additional, SRIRAJASKANTHAN, RAJAVENTHAN, additional, SUZUKI, KOJI, additional, SVASTI, JISNUSON, additional, SZAEFER, HANNA, additional, TEDESCO, IDOLO, additional, TOBE, HIROYASU, additional, TONELLI, DOMENICA, additional, TORRADO-AGRASAR, A., additional, TUBARO, FRANCO, additional, VALLS-BELLÉS, VICTORIA, additional, VANHOECKE, BARBARA, additional, VANHOENACKER, GERD, additional, VEERMAN, E.C.I., additional, VELA, NURIA, additional, VERACHTERT, H., additional, VERSTRAETE, WILLY, additional, VERSTREPEN, K.J., additional, VILLARINO-MARÍN, ANTONIO LUIS, additional, VINSON, JOE A., additional, VOLLMER, GÜNTER, additional, VRIESEKOOP, FRANK, additional, WALKER, CAROLINE, additional, WANNAMETHEE, S. GOYA, additional, WESTENDORF, JOHANNES, additional, WIBETOE, GRETHE, additional, Van De WIELE, TOM, additional, WINKLER, C., additional, WISEMAN, HELEN, additional, WONG, MAX C.Y., additional, WOODMAN, OWEN L., additional, WUNDERLICH, SASCHA, additional, XU, JIN-WEN, additional, YAJIMA, HIROAKI, additional, YAMAMOTO, TETSUYA, additional, YOSHIDA, ARUTO, additional, YOUNG, CHARLES Y.F., additional, ZANOLI, PAOLA, additional, ZAVATTI, MANUELA, additional, ZHAO, FENG, additional, ZIELINSKA-PRZYJEMSKA, MAŁGORZATA, additional, ZIERAU, OLIVER, additional, and ZOTOU, ANASTASIA, additional

Published
2009
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32. Behandlung in der Atemnot-Ambulanz führt zu besserem Umgang mit chronisch refraktärer Atemnot bei Patienten mit fortgeschrittenen Erkrankungen: Ergebnisse der randomisiert-kontrollierten Studie BreathEase [160]

Author

Schunk, M, additional, Le, L, additional, Syunyaeva, Z, additional, Haberland, B, additional, Tänzler, S, additional, Mansmann, U, additional, Schwarzkopf, L, additional, Seidl, H, additional, Streitwieser, S, additional, Hofmann, M, additional, Müller, T, additional, Weiß, T, additional, Morawietz, P, additional, Rehfuess, EA, additional, Huber, RM, additional, Berger, U, additional, and Bausewein, C, additional

Published
2020
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41. Effectiveness of pulmonary rehabilitation for patients with asthma: study protocol of a randomized controlled trial (EPRA)

Author

Schultz, K., Seidl, H., Jelusic, D., Wagner, R., Wittmann, M., Faller, H., Nowak, D., and Schüler, M.

Subjects
Pulmonary and Respiratory Medicine, Work Capacity Evaluation, Anxiety, Act, Asthma, Asthma Control, Economic Evaluation, Inpatient Rehabilitation, Longitudinal, Longitudinal Study, Pulmonary Rehabilitation, Rct, Randomized Controlled Trial, Study Protocol, Inpatient rehabilitation, Asthma control, Germany, Humans, Psychiatric Status Rating Scales, Exercise Tolerance, Depression, Health Care Costs, ACT, Economic evaluation, Pulmonary rehabilitation, Self Care, Dyspnea, Randomized controlled trial, Research Design, Quality of Life, Longitudinal study, RCT, Follow-Up Studies
Abstract

BACKGROUND: Asthma patients are enrolled in multimodal pulmonary rehabilitation (PR) programs. However, available data for the effectiveness of PR in asthma are sparse. Therefore, the primary aim of this randomized control trial (RCT) is to evaluate short-term (end of rehabilitation) and intermediate-term effectiveness (3 months after rehabilitation) of PR for patients with asthma regarding asthma control (primary outcome) and other outcomes. Secondly, moderator effects of gender, age, baseline asthma control, quality of life, and anxiety will be examined. Thirdly, a longitudinal follow-up study will explore the course of the outcomes over one year and the annual costs. METHODS: The EPRA study is a single-center randomized controlled waiting-list trial in the Bad Reichenhall Clinic. Inclusion criteria include a referral diagnosis for uncontrolled asthma, no cognitive impairment and no very severe co-morbidities that indicate significantly greater illness morbidity than asthma alone. In the intervention group (IG), participants will start PR within 4 weeks after randomization; participants of the control group (CG) will start PR 20 weeks after randomization. Data will be assessed at randomization (T0), after 4 weeks (T1; IG: begin of PR), 7 weeks (T2; IG: end of PR), and 20 weeks (T3, CG: begin of PR). The primary outcome is asthma control at T2/T3. Secondary outcomes are health-related quality of life, functional exercise capacity, dyspnea, anxiety, depression, subjective self-management skills, illness perceptions, sick leave and subjective work ability. Outcomes will be analyzed with analysis of covariance, including baseline values of the respective outcomes as covariates. Healthcare costs will be analyzed with a gamma model with a log-link. A longitudinal follow-up study will generate additional data at 3/6/9/12 months after PR for both IG and CG. Latent change models will be used to analyze the course of the primary and secondary outcomes. Annual cost differences before and after rehabilitation will be compared by paired t-test. DISCUSSION: This RCT will determine the effectiveness of a complex inpatient PR for asthma patients concerning asthma control. Furthermore, important medical and economic information regarding the effectiveness of PR as part of the long-term management of patients with uncontrolled asthma will be generated. TRIAL REGISTRATION: German Clinical Trials Register ( DRKS00007740 , May 15, 2015). Protocol version: 1.0 (December, 23, 2016).

Published
2017

42. Nichtpharmakologische Therapie bei Menschen mit kognitiven Einschränkungen. Ergebnisse der randomisierten kontrollierten German-Day-Care-Studie

Author

Straubmeier, M., Behrndt, E.M., Seidl, H., Özbe, D., Luttenberger, K., and Graessel, A.

Abstract

BACKGROUND: A number of non-pharmacological methods are available to help elderly people with cognitive impairment. Unstructured and non-evidencebased interventions are commonly used. The multicomponent therapy MAKS (a German acronym for Motor, Activities of daily living, Cognitive, Social) has already been evaluated in nursing homes; in this study, we investigated its use in day care centers (DCCs). METHODS: A cluster-randomized, controlled, single-blinded trial involving a 6-month intervention phase was performed. 362 cognitively impaired persons in 32 DCCs took part in the trial. Multiple regression analyses were used to determine whether MAKS therapy led to any statistically significant and clinically relevant improvement over time (compared to membership in the control group) in these persons' cognitive abilities and activities of daily living (ADL) abilities, as assessed, respectively, with the Mini-Mental State Examination (MMSE) and the Erlangen Test of Activities of Daily Living in Persons with Mild Dementia or Mild Cognitive Impairment (ETAM). A primary per-protocol analysis was supplemented by an intention-to-treat analysis. Two secondary outcomes (social behavior and neuropsychiatric symptoms) were analyzed exploratively as well. Study registration: ISRCTN16412551. RESULTS: In the primary per-protocol analysis at 6 months, the intervention group had significantly better MMSE and ETAM scores than the control group (Cohen's d, 0.26 and 0.21, respectively; p = 0.012 for both). The same was found in the ITT analysis at 6 months (Cohen's d = 0.21, p = 0.033; and Cohen's d = 0.20, p = 0.019, respectively). Neuropsychiatric symptoms, one of the secondary outcomes, also evolved more favorably in the intervention group (Cohen's d = 0.23, p = 0.055). CONCLUSION: MAKS therapy is effective for persons with cognitive impairment ranging from mild cognitive impairment (MCI) to moderate dementia who live at home and regularly visit a day care center. The fact that 32 day care facilities from all over Germany participated in this study gives its findings high external validity.

Published
2017

43. Validity of self-reported hospital admissions in clinical trials depends on recall period length and individual characteristics

Author

Seidl, H., Meisinger, C., Kirchberger, I., Burkhardt, K., Kuch, B., and Holle, R.

Subjects
Aged, 80 and over, Hospitalization, Interviews as Topic, Male, Clinical Trials as Topic, Mental Recall, Humans, Female, Elderly, Recall Bias, Recall Period, Self-reported Hospital Admissions, Validity, Self Report, Aged
Abstract

RATIONALE, AIMS AND OBJECTIVES: We investigated the validity of self-reported admission data compared to administrative records in a clinical trial. METHOD: In the randomized KORINNA study (ISRCTN02893746), hospital admission data were collected in telephone interviews with 273 elderly patients quarterly over a 1-year period and thereafter annually over a 2-year period. Data were compared with administrative records and discharge letters. Mixed models were used to investigate if recall period and individual characteristics influence validity. RESULTS: Specificity (>99%) and sensitivity (94%) of self-reported data did not differ for different recall periods (3 months vs. 12 months). The differences between self-reported and registered inpatient days were not statistically significant. Having regard to all the admissions within the time period of last interview and dropping out, the bias was up to 40% underestimation. The chance of disagreement was significantly smaller [odds ratio (OR) of misremember an admission = 0.596, P = 0.049, confidence interval (CI) = 0.355 to 1.00; OR of misremember length of stay = 0.521, P = 0.002, CI = 0.344 to 0.789] for 3-month periods, but this was primarily driven by number of admissions within the recall period. Individuals with better health and longer stays had a significantly smaller chance of disagreement. CONCLUSIONS: The bias within one year was not influenced by applying various recall periods, although the probability of correctly self-reported single hospital admission was higher using a recall period of three months. It can be recommended that lengthened recall periods of 12 months are appropriate for gathering self-reported hospital admission data in elderly people with myocardial infarction.

Published
2015

44. BreathEase - Randomisierte kontrollierte Studie zur Evaluation einer multiprofessionellen Atemnotambulanz

Author

Schunk, Michaela, Streitwieser, S., Mansmann, U., Berger, U., Le, L., Rehfuess, E., Müller, T., Hofmann, M., Seidl, H., Holle, Rolf, Huber, R.M., Syunyaeva, Z., and Bausewein, Claudia

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund: Atemnot ist ein häufiges und sehr belastendes Symptom bei Patienten mit fortgeschrittenen Tumorerkrankungen und anderen chronischen Herz- und Lungenerkrankungen, das die Lebensqualität der Patienten deutlich einschränkt und auch zu hohen Belastungen der Angehörigen führt.[zum vollständigen Text gelangen Sie über die oben angegebene URL], 14. Deutscher Kongress für Versorgungsforschung

Published
2015

45. Abstract of the AWMF-Guideline medical clinical Diagnostics of Mold Fungus Exposure in Indoor Rooms

Author

Wiesmueller, G. A., Heinzow, B., Aurbach, U., Bergmann, K. -C., Bufe, A., Buzina, W., Cornely, O. A., Engelhart, S., Fischer, G., Gabrio, T., Heinz, W., Herr, C. E. W., Kleine-Tebbe, J., Klimek, L., Koeberle, M., Lichtnecker, H., Lob-Corzilius, T., Merget, R., Muelleneisen, N., Nowak, D., Rabe, U., Raulf, M., Seidl, H. P., Steiss, J. -O., Szewzyk, R., Thomas, P., Valtanen, K., Hurrass, J., Wiesmueller, G. A., Heinzow, B., Aurbach, U., Bergmann, K. -C., Bufe, A., Buzina, W., Cornely, O. A., Engelhart, S., Fischer, G., Gabrio, T., Heinz, W., Herr, C. E. W., Kleine-Tebbe, J., Klimek, L., Koeberle, M., Lichtnecker, H., Lob-Corzilius, T., Merget, R., Muelleneisen, N., Nowak, D., Rabe, U., Raulf, M., Seidl, H. P., Steiss, J. -O., Szewzyk, R., Thomas, P., Valtanen, K., and Hurrass, J.

Published
2017

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