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The main objective of this research was to analyze the impact and development of intervention programs based on the Teaching Personal and Social Responsibility (TPSR) model within the school context. A systematic review was conducted in seven international databases. The keywords "TPSR" and "Education" were used in different combinations with other terms. Following the review process, 21 research studies met the eligibility criteria and were analyzed. Studies outside of USA represented most of the studies included in this review. The results showed the importance of continuing professional development and the fidelity of the implementations to achieve greater adherence to the TPSR model (teachers) and improvements in different dimensions (students): behavioral, psychological, social, and affective. Interdisciplinary and multidisciplinary application of TPSR could enhance the effects and benefits of TPSR. [ABSTRACT FROM AUTHOR]

Uptake of COVID-19 vaccine booster doses is an important public health topic of study to prevent morbidity and mortality in underserved U.S. populations. However, limited research exists on COVID-19 vaccine booster use and willingness - including its associated factors - among Asian Americans (AA): the fastest growing racial group in the U.S. This study collected survey data from 447 AA adults from three large AA subgroups: Chinese, Korean, and Filipino. Data were collected as part of a community-driven county-wide needs assessment conducted in collaboration with AA community organizations in Riverside County, California. Data indicated that nearly 24% of AA participants received at least four doses of the COVID-19 vaccine, with 36% expressing definite willingness to receive future booster doses. Participants reported experiencing an average of 1.6 instances of racial discrimination across their lifetime. Ordered logistic regression and marginal effects analysis revealed ethnicity, education, racial discrimination, preexisting health conditions, and the number of prior COVID-19 vaccine doses received significantly predicted willingness to receive future vaccine doses. The study suggests that key social factors such as racial discrimination may play an important role in influencing public health efforts to promote vaccine uptake in diverse Asian American populations.

Although the αC-β4 loop is a stable feature of all protein kinases, the importance of this motif as a conserved element of secondary structure, as well as its links to the hydrophobic architecture of the kinase core, has been underappreciated. We first review the motif and then describe how it is linked to the hydrophobic spine architecture of the kinase core, which we first discovered using a computational tool, local spatial Pattern (LSP) alignment. Based on NMR predictions that a mutation in this motif abolishes the synergistic high-affinity binding of ATP and a pseudo substrate inhibitor, we used LSP to interrogate the F100A mutant. This comparison highlights the importance of the αC-β4 loop and key residues at the interface between the N- and C-lobes. In addition, we delved more deeply into the structure of the apo C-subunit, which lacks ATP. While apo C-subunit showed no significant changes in backbone dynamics of the αC-β4 loop, we found significant differences in the side chain dynamics of K105. The LSP analysis suggests disruption of communication between the N- and C-lobes in the F100A mutant, which would be consistent with the structural changes predicted by the NMR spectroscopy.

Dynamic protein structures are crucial for deciphering their diverse biological functions. Two-dimensional infrared (2DIR) spectroscopy stands as an ideal tool for tracing rapid conformational evolutions in proteins. However, linking spectral characteristics to dynamic structures poses a formidable challenge. Here, we present a pretrained machine learning model based on 2DIR spectra analysis. This model has learned signal features from approximately 204,300 spectra to establish a spectrum-structure correlation, thereby tracing the dynamic conformations of proteins. It excels in accurately predicting the dynamic content changes of various secondary structures and demonstrates universal transferability on real folding trajectories spanning timescales from microseconds to milliseconds. Beyond exceptional predictive performance, the model offers attention-based spectral explanations of dynamic conformational changes. Our 2DIR-based pretrained model is anticipated to provide unique insights into the dynamic structural information of proteins in their native environments.

Background: Osteochondral allograft transplantation (OCA) is well established as a viable chondral restoration procedure for the treatment of symptomatic, focal chondral defects of the knee. The efficacy of secondary OCA in the setting of failed index cartilage repair or restoration is poorly understood. Purpose: To evaluate radiographic and clinical outcomes, failures, and reoperations after OCA after failed index cartilage repair or restoration of the knee. Study Design: Systematic review; Level of evidence, 4. Methods: A systematic review was conducted in accordance with the 2020 PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A literature search was conducted by querying PubMed, MEDLINE, Scopus, the Cochrane Database for Systematic Reviews, and the Cochrane Central Register for Controlled Trials databases from inception through September 2023 to identify studies reporting on outcomes of patients undergoing OCA after failed index chondral repair or restoration. Results: A total of 6 studies, entailing 349 patients, met inclusion criteria. The mean patient age was 34.6 ± 10.2 years. The mean chondral defect size at the time of secondary OCA was 5.8 cm2 (range, 4.0-9.5 cm2), and the most common defect location was the medial femoral condyle (53.6%; n = 171/319). The most common index chondral procedures were marrow stimulation (73.8%; n = 256/347 patients), OCA (11.8%; n = 41/347), and autologous chondrocyte implantation (4.9%; n = 17/347). The overall failure rate after secondary OCA was 16.6% (95% CI, 8.8%-24.4%). The overall reoperation rate was 42.8% (95% CI, 31.7%-53.9%). Failure and reoperation rates were associated with increasing chondral defect size (P <.01). Defects 9-10 cm2 had a reoperation rate of 67% and a failure rate of 39%. The 5-year survival rate after secondary OCA was 79% to 87.8%, and the 10-year survival rate was 61% to 82%. A total of 42 clinical outcome scores were reported, and 71.0% (n = 22/31) of patient-reported outcome measures yielded significant improvement from preoperative to postoperative levels for patients undergoing secondary OCA. Conclusion: After index chondral surgery, the overall failure rate after secondary OCA was 16.6%, with an overall reoperation rate of 42.8%. The majority of clinical outcomes reported suggest improvement when compared with preoperative values. Larger chondral defects may be associated with higher rates of failure and reoperation. [ABSTRACT FROM AUTHOR]

Psychopathy has interested researchers since its conceptualization by Cleckley in 1941. This interest has come almost exclusively in the form of quantitative inquiries. Quantitative studies have provided valuable insights into the etiology, heterogeneity, and treatment of the disorder. At the same time, rich phenomenological descriptions of psychopathy have a role to play in the field since they can inform the development of variant-specific assessment instruments, as well as the development or tailoring of psychological interventions. Qualitative methods offer distinct advantages, since their flexibility and explorative nature allow the capture of unanticipated, novel, or nuanced psychopathy aspects, which can be overlooked when using pre-set hypotheses and structured measures. In light of these considerations, the present narrative review aims to (a) provide an overview of the state-of-the-art in psychopathy research, by combining insights from both quantitative and qualitative studies and (b) draw attention to the need for a qualitative approach in the field. It dives into conceptualization, etiology, youth psychopathy and temporal stability of psychopathic traits, the distinction between variants (primary versus secondary), and treatment, before reviewing qualitative studies and formulating an argument in favor of exploring the lived experience of psychopathy. The most recent developments in the field are also examined, including the first contemporary theory on secondary psychopathy etiology and the first-ever treatment studies exploring differential outcomes between variants. [ABSTRACT FROM AUTHOR]

The present study examined student outcomes from a quantum information science and technology (QIST) summer outreach program for U.S. secondary students. The program focused on foundational principles and skills from classical physics, quantum physics, and quantum computing. Students' attitudes towards QIST learning and careers were measured through a pretest/posttest research design. Exploratory factor analysis was utilized to identify latent attitudinal themes, followed by comparisons of means to measure changes in these factors and analysis of covariance to assess whether these changes were related to student demographics and prior academic coursework. Two latent themes were identified: (1) QIST career aspiration formation and self-concept, and (2) QIST interest and behavioral intentions. Results indicated that students improved their QIST career aspiration formation and self-concept with a medium to large effect size, yet their QIST interest and behavioral intentions were unchanged. These results were independent of student demographics (gender, ethnicity, grade level) and prior mathematics and computer science course enrollment; however, students who had previously taken chemistry and physics were more likely to improve QIST career aspiration formation and self-concept. Students also increased their intention to take four years of elective mathematics and science with a small effect size. These results suggest that early exposure to QIST principles, skills, and applications may increase students' consideration of related careers and academic coursetaking plans; however, their interest in QIST may be independent of career aspiration formation. Further research is needed to measure attitudinal sub-domains that may be influenced by early QIST education and specific programmatic elements. [ABSTRACT FROM AUTHOR]

Understanding the interaction of hemoglobin (Hb) with various nanomaterials and nanoparticles (NPs) is of considerable interest for the design of enhanced oxygen carriers for therapeutic applications. In this report, we undertake an iterative study of the role of the capping ligand in determining the nature of Hb binding to the surface of spherical gold nanoparticles (AuNPs, 5 nm diameter). We show that AuNPs capped with citrate and thioctic acid TA-SO3 ligands show robust assembly of Hb to the AuNP surface while NPs capped with TA-CL4 ligands (short, zwitterionic ligands) exhibit minimal assembly of Hb to the NP surface. Citrate on the AuNP facilitates the efficient assembly of Hb to the NP surface through the formation of an Au–S bond between Au and free thiols on cysteine residues. Conversely, TA-SO3-capped AuNPs mediate the electrostatic assembly of Hb to the ligand coating. Hb assembly on the citrate and TA-SO3 AuNPs significantly changes the AuNP physical properties (e.g., hydrodynamic diameter, surface charge, and colloidal stability). Hb assembly on the citrate-AuNPs alters its spectral properties, while Hb assembly to TA-SO3-AuNPs shows minimal changes in AuNP spectral properties. More importantly, Hb undergoes different degrees of spectral and interstitial structural alterations, including changes to the heme absorption peak and modification in the secondary structure, upon being assembled with the AuNP. Circular dichroism (CD) spectroscopy data confirms a significant (50%) loss of Hb α-helix structure when assembled on the citrate-AuNP compared with TA-SO3-AuNP. Our results demonstrate the important consideration that must be given to the ligand coating when interfacing Hb (and other proteins) with NP materials for bioconjugate formation. [ABSTRACT FROM AUTHOR]

High rates of teacher praise are associated with positive student outcomes (Royer et al., 2019). Research shows secondary teachers deliver more reprimands than praise (e.g. Floress et al. 2022). Performance feedback (PF) is a strategy used to change teacher behaviors. However, it is unknown if PF targeting praise and reprimands for secondary teachers is an evidence-based practice. Although reviews on PF exist, none focus exclusively on secondary teachers. This review was to synthesize 14 PF intervention studies targeting praise and reprimands for secondary teachers. We evaluated PF studies to determine if PF is an evidence-based practice. Results indicate PF targeting praise and reprimands cannot yet be determined as an evidence-based practice for secondary teachers. Limitations, implications, and future directions are discussed. [ABSTRACT FROM AUTHOR]

Transradial secondary access (TR-SA) may serve as an alternative to the traditional femoral secondary access (TF-SA) for pigtail placement in transcatheter aortic valve replacement (TAVR). The aim of this study was to assess the incidence of secondary access–related vascular complications after TR-SA or TF-SA in TAVR. The PULSE (Plug or sUture based vascuLar cloSurE after TAVR) registry retrospectively evaluated data of 10,120 patients who underwent transfemoral TAVR at 10 heart centers from 2016 to 2021. We compared TR-SA and TF-SA groups of 8,851 patients with available data regarding the secondary access location and validated observed data in 1:1 propensity score matching. Outcomes were evaluated according to Valve Academic Research Consortium 3 definitions. The median age was 82.0 ± 6.9 years, and 49.1% (4,346/8,851) of patients were female. TR-SA was selected in 1,686 patients (19.0%) and TF-SA in 7,165 (81.0%) overall. Vascular complications at the secondary access occurred in 0.3% (5/1,686 [TR-SA]) vs 3.2% (232/7,165 [TF-SA]; P < 0.001) and were considered major in 0.2% (3/1,686 [TR-SA]) vs 1.5% (109/7,165 [TF-SA]) and minor in 0.1% (2/1,686 [TR-SA]) vs 1.7% (123/7,165 [TF-SA]; P < 0.001 for both). Surgical repair was required in 0 TR-SA patients and in 0.9% (66/7,165) of TF-SA patients. Primary access vascular complications were similar (11.6% (196/1,686 [TR-SA]) vs 11.5% (825/7,165 [TF-SA]); P = 0.93); bleeding type III/IV occurred less with TR-SA (2.5% [42/1,686] vs 4.7% [334/7,165] with TF-SA; P < 0.001). After propensity score matching, secondary access–related vascular complication rates remained lower for TR-SA (0.2% [1/512] vs 2.9% [15/512] for TF-SA; P < 0.001). During transfemoral TAVR, TR-SA was associated with lower rates of access site complications and severe bleeding compared to TF-SA. In fact, secondary access–related complications were 10× higher for TF-SA and frequently required invasive treatments. These findings challenge the fact that most TAVR procedures are still performed with TF-SA. [Display omitted] [Display omitted] [ABSTRACT FROM AUTHOR]

Saponins encompass a diverse group of naturally occurring glycoside molecules exhibiting amphiphilic properties and a broad range of biological activities. There is a resurgence of interest in those saponins produced by marine organisms based on their potential therapeutic benefits, application in food products and most recently their potential involvement in intra- and inter-species chemical communication. The continual advancements in liquid chromatography techniques and mass spectrometry technologies have allowed for greater detection rates, as well as improved isolation and elucidation of saponins. These factors have significantly contributed to the expansion in the catalogue of known saponin structures isolated from marine invertebrates; however, there currently exists no specific chemical library resource to accelerate the discovery process. In this study, a Marine Animal Saponin Database (MASD v1.0) has been developed to serve as a valuable chemical repository for known marine saponin-related data, including chemical formula, molecular mass and biological origin of nearly 1000 secondary metabolites associated with saponins produced by marine invertebrates. We demonstrate its application with an exemplar asteroid extract (Acanthaster cf. solaris, also known as crown-of-thorns starfish; COTS), identifying saponins from the MASD v1.0 that have been previously reported from COTS, as well as 21 saponins isolated from multiple other related asteroid species. This database will help facilitate future research endeavours, aiding researchers in exploring the vast chemical diversity of saponins produced by marine organisms and providing ecological insights, and the realisation of their potential for various applications, including as pharmaceuticals. [ABSTRACT FROM AUTHOR]

Let n be a positive integer different from 8 and n + 1 ≠ 2 u for any integer u ≥ 2 . Let ϕ (x) belonging to Z [ x ] be a monic polynomial which is irreducible modulo all primes less than or equal to n + 1 . Let a j (x) with 0 ≤ j ≤ n - 1 belonging to Z [ x ] be polynomials having degree less than deg ϕ (x) . Assume that the content of a n a 0 (x) is not divisible by any prime less than or equal to n + 1 . We prove that the polynomial f (x) = a n ϕ (x) n (n + 1) ! + ∑ j = 0 n - 1 a j (x) ϕ (x) j (j + 1) ! is irreducible over the field Q of rational numbers. This generalises a well-known result of Schur which states that the polynomial ∑ j = 0 n a j x j (j + 1) ! with a j ∈ Z and | a 0 | = | a n | = 1 is irreducible over Q . For proving our results, we use the notion of ϕ -Newton polygons and a few results on primes from number theory. We illustrate our result through examples. [ABSTRACT FROM AUTHOR]

Artificial intelligence (AI) literacy has emerged to equip students with digital skills for effective evaluation, communication, collaboration, and ethical use of AI in online, home, and workplace settings. Countries are increasingly developing AI curricula to support students' technological skills for future studies and careers. However, there is a lack of reviews summarizing AI education in secondary schools. This study aims to provide an up-to-date summary of the literature, informing researchers, policymakers, and educators on fostering students' AI literacy. A thematic analysis of 50 AI education studies from 2016 to 2022 was conducted, evaluating pedagogies, teaching tools, learning contents, and assessment methods among secondary students. Results were identified: (1) Collaborative project-based learning, involving interdisciplinary problem-solving through artifact creation, emerged as the most common pedagogical approach; (2) Teaching tools were categorized into hardware, software, intelligent agents, and unplugged tools; (3) Junior students focused on experiencing AI and basic concepts, while senior students explored advanced and technical components; (4) Assessments included knowledge tests, questionnaires, and qualitative analysis (e.g., videos, documents, presentations); (5) Students' learning effects were measured across affective, behavioral, cognitive, and ethical dimensions. The study identifies suggestions and challenges for implementing AI education in secondary schools, offering valuable insights and recommendations for educators and decision-makers. [ABSTRACT FROM AUTHOR]

The aim of this article is to offer an approach that can be used to develop Decolonial Critical Awareness (CDA) and Decolonial Critical Reflection (CDR) in student language teachers at post-Primary level as part of their Initial Teacher Education (ITE). The article contextualises the rationale for such provision in ITE programmes in the wider debates related to the decolonisation of curricula, especially language curricula, in Higher Education. It also offers a view of language education policy in the Irish context when viewed through a decolonising lens arguing that CDA and CDR help develop skills, knowledge and values in student teachers to develop their identities as agents of change. The views of the student teachers who engaged with the approach show that while effective in fostering decolonial awareness, wider systemic barriers prevent them from feeling like they can instigate real change. The article concludes by emphasising the importance of this newly emerging area of research at post-Primary level and the need for further similar contributions in the Irish context. [ABSTRACT FROM AUTHOR]

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Assistive technology (AT) is a critical in providing students with visual impairments (VI) access to classroom information. However, little is known about how the fluid and diverse experiences across core-content classrooms that impact the nature of AT use among students with VI. We conducted three classroom observations of 10 secondary-age (i.e., 6th through 12th grade) students with VI in core-content classrooms (i.e., math, English, social studies, or science). Wide variations in AT use suggest that AT needs are individualized. Additionally, writing tasks, reading tasks, and independent instructional groupings were associated with the highest rates of AT usage. However, students receive little support for using their AT in classrooms. We offer implications and recommendations for research and practice aimed at increasing AT use in core-content classrooms. [ABSTRACT FROM AUTHOR]

Postmortem biochemistry is a valuable tool in forensic investigations, providing insights into the tissue damage and organ dysfunction associated with death. This study aimed to identify biochemical markers that distinguish primary and secondary hypothermia. Twenty-one Wistar rats were allocated into three groups: the Control group (n = 7), which was exposed only to hypothermic conditions, the Alcohol + Hypothermia group (n = 7), and the Benzodiazepines + Hypothermia group (n = 7). The temperature metrics assessed included the normal core temperature, the post-ketamine (0.3 ml injection) core temperature, the immersion temperature, temperature at the onset of hypothermia, and temperature at death. Blood samples were collected from the thoracic aorta in EDTA vacuum tubes for biochemical analysis. The key biochemical parameters measured included the Total Protein (g/L), Albumin (g/L), Globulin (g/L), Albumin to Globulin Ratio, Alanine Aminotransferase (U/L), Alkaline Phosphatase (U/L), Cholesterol (mmol/L), Amylase (U/L), and Lipase (U/L), using an automated IDEXX (Netherlands) cell counter. Significant between-group differences were found for the total protein and globulin levels (p < 0.001 and p = 0.002, respectively), with post-hoc tests confirming differences between the alcohol and control, and benzodiazepine and control groups. The cholesterol levels were found to be significantly different through an omnibus test (p = 0.03), but post hoc tests did not confirm these differences on a statistically significant level. The amylase levels varied significantly across all groups (p < 0.001), with post hoc tests confirming significant differences among all pairs: alcohol vs. benzodiazepine (p = 0.002), alcohol vs. control (p = 0.003), and benzodiazepine vs. control (p < 0.001). The lipase levels showed significant differences in the omnibus test (p = 0.030), but there was no significance in the post hoc tests. Amylase emerged as the most significant parameter in our study, with reduced levels strongly associated with secondary hypothermia. These findings highlight the potential use of total protein, globulin, and amylase levels as biomarkers to differentiate between primary and secondary hypothermia in forensic contexts. [ABSTRACT FROM AUTHOR]

Impact cratering is one of the fundamental processes throughout the history of the Solar System. The formation of new impact craters on planetary bodies has been observed with repeat images from orbiting satellites. However, the time gap between images is often large enough to preclude detailed analysis of smaller‐scale features such as secondary impact craters, which are often removed or buried over a short time period. Here we use a seismic event detected on Mars by the NASA InSight mission to investigate secondary cratering at a new impact crater. We strengthen the case that the seismic event that occurred on Sol 1034 (S1034a) is the result of a new impact cratering event. Using the exact timing of this event from InSight, we investigated the resulting new impact crater in orbital image data. The S1034a impact crater is approximately 9 m in diameter but is responsible for over 900 secondary impact events in the form of low albedo spots that are located at distances of up to almost 7 km from the primary crater. We suggest that the low albedo spots formed from relatively low energy ejecta, with individual ejecta block velocities less than 200 m s−1. We estimate that the low albedo spots, the main evidence of secondary impact processes at this new impact event, fade within 200–300 days after formation. Plain Language Summary: On 23 October 2021, the seismometer instrument on the NASA InSight lander detected a seismic event on Mars. The nature of the seismic signal shared characteristics with other events attributed to meteorites impacting the surface of Mars. Reanalysis of images taken by cameras on orbiting spacecraft identified a new impact crater whose location and time of formation matched with the seismic analysis. Our study shows that this 9 m diameter crater has produced over 900 additional, or secondary, impact features up to 7 km away. These secondary features are characterized as being dark spots, often with a tail that points away from the direction of impact, which fade over time. The relatively high number of secondary features from this small impact event is likely due to the low porosity of the rock that was impacted at the surface. We estimate that the dark spots disappear in 200–300 days, thus removing a key set of features used in identifying new impact events on Mars. This timescale places useful limits for future image searches attempting to identify small new impact craters on Mars, and suggests that other such small impact events have been captured in existing data sets and not yet recognized. Key Points: A new 9‐m‐diameter impact crater on Mars identified with in situ seismic and orbital image dataOver 900 low albedo spots identified as a result of secondary ejecta processesSmall impact events have likely been captured in existing data sets and not yet recognized [ABSTRACT FROM AUTHOR]

Purpose: This study aims to compare the outcomes of suture-less and multiple suture closure methods on postoperative pain, swelling, and trismus, and associated complications. Materials and methods: This prospective, randomized clinical trial was conducted at the Department of Oral & Maxillofacial Surgery, Goa Dental College & Hospital. Inclusion criteria encompassed subjects aged between 17 and 55 years, classified as American Society of Anaesthesiologists (ASA) I, with asymptomatic impacted third molars falling within the moderately difficult impaction range (Pederson's difficulty index: 5–7). Study excluded individuals classified as ASA II, III, or IV, those with known or suspected allergies to the anaesthetic solution, immunocompromised patients, and individuals taking medications that could affect healing. Pregnant or lactating females and those with a history of bleeding disorders were also excluded. Wound closure methods were compared: Group A underwent primary closure with silk sutures, while Group B had suture-less closure. Subjects were allocated to the specific groups using a simple randomization method. This involved using a lottery-based random sequence to assign each participant to either Group A or Group B. Pain intensity, facial swelling, and trismus were key outcomes. Secondary outcomes included lingual nerve sensation and postoperative complications. Demographics factors, surgical details, radiographic and perioperative data, and physiological parameters were considered. Non-parametric tests and parametric test (repeated measure ANOVA) were employed. Statistical significance was set at P < 0.05. Results: Among 101 participants, both closure techniques exhibited similar outcomes in pain, swelling, and lingual nerve function. However, suture-less closure resulted in significantly less trismus and fewer cases of delayed wound healing. Conclusions: Suture-less method after surgical removal of third molar may reduce trismus compared to multiple sutures. While pain, swelling, and lingual nerve function management were comparable. [ABSTRACT FROM AUTHOR]

Central adrenal insufficiency (CAI) occurs due to a pituitary gland disorder (secondary AI) or hypothalamic dysfunction (tertiary AI). It is a potentially life-threatening condition that has many congenital and acquired causes. Adrenocorticotropic hormone deficiency may be isolated or more commonly it can be accompanied by other pituitary hormone deficiencies or midline defects. The signs and symptoms of CAI are associated with glucocorticoid deficiency. A three-step diagnostic approach including dynamic stimulation tests is recommended in the evaluation of patients with suspected CAI. Here, members of the ‘Adrenal Working Group' of ‘The Turkish Society for Pediatric Endocrinology and Diabetes' present an evidence-based review with good practice points and recommendations for etiology and diagnostic approach in children and adolescents with CAI.

Background: Breast lymphomas are a rare group of malignancies that are further subdivided into primary and secondary. AIMS: To study the pathological and clinical course of breast lymphomas. Materials and Methods: This is a retrospective analysis of patients treated at our institute over a period of 4.5 years from September 2018 to February 2023. The details of all the patients diagnosed with breast lymphoma were reviewed and analysed for the histomorphological, immunohistochemical, clinical, and treatment details. Appropriate statistical analysis including Kaplan-Meier methods was used. Results: Out of 11 cases of breast lymphoma, five were primary and six were secondary. It was seen predominantly in females (82%) and the age range was 31 to 73 years. Diffuse large B cell lymphoma (DLBCL) was the predominant morphology (73%), along with single rare cases of ALK-negative anaplastic large cell lymphoma, Burkitt lymphoma, and small lymphocytic lymphoma. The treatment details were analyzed for 7 patients. The median follow-up was 28 months. Rituximab along with CHOP regimen or its variants was commonly used as first-line treatment with initial response rates of 71%. The median progression-free survival was 5 months. The median overall survival was 15 months. Conclusion: Lymphomas of the breast are rare but it is crucial to differentiate them from the commoner breast carcinomas as the treatment and prognosis vary vastly.

Many peptide hormones form an α-helix on binding their receptors1-4, and sensitive methods for their detection could contribute to better clinical management of disease5. De novo protein design can now generate binders with high affinity and specificity to structured proteins6,7. However, the design of interactions between proteins and short peptides with helical propensity is an unmet challenge. Here we describe parametric generation and deep learning-based methods for designing proteins to address this challenge. We show that by extending RFdiffusion8 to enable binder design to flexible targets, and to refining input structure models by successive noising and denoising (partial diffusion), picomolar-affinity binders can be generated to helical peptide targets by either refining designs generated with other methods, or completely de novo starting from random noise distributions without any subsequent experimental optimization. The RFdiffusion designs enable the enrichment and subsequent detection of parathyroid hormone and glucagon by mass spectrometry, and the construction of bioluminescence-based protein biosensors. The ability to design binders to conformationally variable targets, and to optimize by partial diffusion both natural and designed proteins, should be broadly useful.

Complex II (CII) activity controls phenomena that require crosstalk between metabolism and signaling, including neurodegeneration, cancer metabolism, immune activation, and ischemia-reperfusion injury. CII activity can be regulated at the level of assembly, a process that leverages metastable assembly intermediates. The nature of these intermediates and how CII subunits transfer between metastable complexes remains unclear. In this work, we identify metastable species containing the SDHA subunit and its assembly factors, and we assign a preferred temporal sequence of appearance of these species during CII assembly. Structures of two species show that the assembly factors undergo disordered-to-ordered transitions without the appearance of significant secondary structure. The findings identify that intrinsically disordered regions are critical in regulating CII assembly, an observation that has implications for the control of assembly in other biomolecular complexes.

Syphilis is a sexually transmitted infection with manifestations that can mimic other diseases, leading to misdiagnosis. Annular syphilis is a rare atypical secondary syphilitic lesion that seldomly involves the face. Human immunodeficiency virus (HIV) coinfection can increasingly lead to atypical manifestations of syphilis and complicate the diagnosis. Herein, we describe a 29-year-old man with a diagnosis of annular secondary syphilis and HIV coinfection. He had clinical manifestations of annular erythematous papules and plaques with white scales at the edges, distributed and scattered on the face, neck, and upper back. The skin lesions went undetected on several visits and were misdiagnosed owing to similarities with other dermatoses. Serological examination showed positive Treponema pallidum particle agglutination assay and venereal disease research laboratory test titer 1/512, confirming syphilis infection. Results from the histopathological examination supported the diagnosis of secondary syphilis. Positive anti-HIV rapid test results indicated concurrent HIV infection. He was treated for syphilis and given antiretroviral therapy, and showed a good response as demonstrated by improvement of the lesions and serological titers. This case highlights the importance of recognizing the possibility of annular secondary syphilis and HIV coinfection which can have atypical manifestations.

BackgroundGiven the waning of vaccine effectiveness and the shifting of the most dominant strains in the U.S., it is imperative to understand the association between vaccination coverage and Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) disease and mortality at the community levels and whether that association might vary according to the dominant SARS-CoV-2 strains in the U.S.MethodsGeneralized estimating equations were used to estimate associations between U.S. county-level cumulative vaccination rates and booster distribution and the daily change in county-wide Coronavirus 2019 disease (COVID-19) risks and mortality during Alpha, Delta and Omicron predominance. Models were adjusted for potential confounders at both county and state level. A 2-week lag and a 4-week lag were introduced to assess vaccination rate impact on incidence and mortality, respectively.ResultsAmong 3,073 counties in 48 states, the average county population complete vaccination rate of all age groups was 50.79% as of March 11th, 2022. Each percentage increase in vaccination rates was associated with reduction of 4% (relative risk (RR) 0.9607 (95% confidence interval (CI): 0.9553, 0.9661)) and 3% (RR 0.9694 (95% CI: 0.9653, 0.9736)) in county-wide COVID-19 cases and mortality, respectively, when Alpha was the dominant variant. The associations between county-level vaccine rates and COVID-19 incidence diminished during the Delta and Omicron predominance. However, each percent increase in people receiving a booster shot was associated with reduction of 6% (RR 0.9356 (95% CI: 0.9235, 0.9479)) and 4% (RR 0.9595 (95% CI: 0.9431, 0.9761)) in COVID-19 incidence and mortality in the community, respectively, during the Omicron predominance.ConclusionsAssociations between complete vaccination rates and COVID-19 incidence and mortality appeared to vary with shifts in the dominant variant, perhaps due to variations in vaccine efficacy by variant or to waning vaccine immunity over time. Vaccine boosters were associated with notable protection against Omicron disease and mortality.

We prove a heavy traffic scaling limit for a shortest remaining processing time queue. We are interested in the case where the processing time distribution has a tail that decays rapidly, i.e., has light tails. In particular, we revisit the work in Puha (2015), which shows that the diffusion scaled queue length process multiplied by a processing time distribution dependent factor that tends to infinity converges to a nontrivial reflecting Brownian motion, under the condition that this distribution dependent factor is slowly varying and obeys a certain rate of convergence condition. Here, we prove that the rate of convergence condition is not needed and the result holds more generally. We further show convergence of a sequence of nonstandardly scaled measure valued state descriptors to a point mass at one such that the total mass fluctuates randomly in accordance with the diffusion limit for the workload process. This is a sharp concentration result which shows that, under this nonstandard scaling, there are a very small number of tasks in the system and the remaining work for each such task is large and of the same order of magnitude as that of other tasks. This is due to the prioritization of the task with the least remaining work, and is in contrast to the case of heavy tailed processing times studied in Banerjee, Budhiraja, and Puha (2022). There it is shown that, while there is some concentration, the remaining times of the very small number of tasks in the system spread out over the nonnegative real line according to a random profile under this nonstandard scaling. Thus, this work completes the description of the two fundamentally different behaviors of SPRT by characterizing it in the case of light tailed processing time distributions. [ABSTRACT FROM AUTHOR]

Central adrenal insufficiency (CAI) occurs due to a pituitary gland disorder (secondary AI) or hypothalamic dysfunction (tertiary AI). It is a potentially life-threatening condition that has many congenital and acquired causes. Adrenocorticotropic hormone deficiency may be isolated or more commonly it can be accompanied by other pituitary hormone deficiencies or midline defects. The signs and symptoms of CAI are associated with glucocorticoid deficiency. A three-step diagnostic approach including dynamic stimulation tests is recommended in the evaluation of patients with suspected CAI. Here, members of the 'Adrenal Working Group' of 'The Turkish Society for Pediatric Endocrinology and Diabetes' present an evidence-based review with good practice points and recommendations for etiology and diagnostic approach in children and adolescents with CAI. [ABSTRACT FROM AUTHOR]

Abstract Anti-microbial stewardship program (AMSP) is practiced only in tertiary hospitals in India, though, the lower tier hospitals remain the first point of contact in patient care. This study was conducted in lower tier hospitals to calculate antibiotic and multiple antibiotic prescription rate (APR, MPR) for common infections and finding existing strength of health system for optimizing antibiotic prescription. We conducted a cross sectional convergent parallel mix-method study in eight lower tier hospitals of three districts of West Bengal, India. Six hundred OPD prescriptions of UTI, ARI, AUFI, ADD were evaluated. Qualitative data collected through in-depth interviews of medical officers/officers in administrative positions, infection control nurses were analyzed using content analysis method. APR was 63.8% in primary tier hospitals and 60.8% in secondary tier hospitals. The MPR was higher in secondary tier hospital (23.8%). Presence of infection control committee, designated nursing staff, initiation of prescription audit, increased monitoring were identified as few facilitators for future implementation of AMSP in lower tier hospitals. The routine infection control activities of lower tier hospitals are currently delinked from AMR containment measures and thus, customized AMSP needs to be established in these hospitals catering two third of the population of India.

In the paper entitled Comparative analysis of employed population and the gross domestic product in Romania and the RomanianWestern Region, by sectors of activity, the dynamics of employed population and gross domestic product before and during the pandemic, respectively the period 2016-2021 has been analysed. Based on the comparative analysis of the employed population in Romania and in the Western Region of the same country, for the period 2016-2018, a dynamic in the primary sector was found, a decrease in the secondary sector and an increase in the tertiary sector. In the period 2019-2021, the employed population,by sector of activity,decreased in the primary sector, was dynamic in the secondary sector and increasedin the tertiary sector. There are significant differences between the average percentages calculated for the WesternRegion compared to Romania, which shows a decrease in the employed population in the primary and tertiary sectors and an increase in the secondary. In terms of gross domestic product in current prices, over the entire period 2016-2021, Romania’s gross domestic product by sectors of activity recorded an increase in the primary and tertiary sectors and a dynamic in the secondary sector. At the level of the Western Region, in the period 2016-2019, in all sectors of activity, the gross domestic product in current prices increased. Due to the emergence of the pandemic in 2020, there are decreases in GDP in current prices in all sectors of activity, but from 2021 onwards the economy recovers, so that its values increased both in Romania and in the Western Region.

Abstract Background Secondary schools are important settings for promoting varied physical activity (PA) opportunities for adolescents to promote PA throughout life. However, research on the effect of secondary school-based interventions on future PA is limited. This study examined the potential impact of secondary school-based interventions on the determinants of future PA participation of Aotearoa New Zealand (NZ) adolescents using simulated modelling. Methods We used data from a nationally representative sample of secondary school students (n = 5035) aged 12–17 between 2017 and 2020 in NZ. We modelled four secondary school-based interventions and their projected impact on five determinants of future PA. Modelled interventions were the technological augmentation of physical education (TAPE), a peer-led PA mentoring programme (PL), physically active learning (PAL) and the inclusion of a natural environment play area (NE). Results Total weekly PA increased the most from the NE intervention (+ 0.2 h/week), followed by TAPE (+ 0.08 h/week), PAL (+ 0.05 h/week) and PL (-0.06 h/week). Current number of PA settings increased the most in NE (+ 1.75 settings/week), followed by TAPE (+ 1.29 settings/week), PAL (+ 1.21 settings/week) and PL (+ 0.73 settings/week). Current number of PA types increased the most in NE (+ 1.57 types/week), followed by PL (+ 1.05 types/week), TAPE (+ 0.34 types/week) and PAL (+ 0.15 types/week). Physical literacy scores increased the most from PL (+ 3.6%), followed by PAL (+ 3.3%), TAPE (+ 0.43%) and NE (+ 0.12%). Social support scores increased the most from PAL (+ 5%), followed by PL (+ 1.9%), TAPE (+ 1.46%) and NE (+ 0.57%). Conclusions On average, all interventions benefitted determinants of future PA participation to a small degree. Results show differing magnitudes of the intervention effect by determinant, indicating the complexities surrounding the promotion of PA adherence. Future interventions could be improved through detailed consultation alongside, and involving, adolescents and stakeholders within schools. Researchers should also prioritise the collection of longitudinal PA data and explore its connection with sociodemographic differences between adolescents.

Abstract Purpose This study aimed to compare demographics, clinical characteristics, and post-surgical outcomes between idiopathic and secondary full-thickness macular holes (MHs). Methods A retrospective analysis of 348 eyes from 339 patients treated between June 2017 and December 2023 was conducted. The study included both idiopathic and secondary MHs, excluding cases where surgery was not performed or lacked sufficient follow-up. Demographic data, visual acuity (VA), ocular characteristics, and optical coherence tomography measurements were analyzed. Results Idiopathic MHs were identified in 308 eyes (89%), and secondary MHs in 40 eyes (11%). Idiopathic MH patients were older (mean age: 68.26 vs. 60.13 years; p = 0.001) and more commonly female (63% vs. 40%; p = 0.005). Post-surgical closure was achieved in 86% of all MHs, with a median VA improvement of 15 ETDRS letters (3 Snellen lines). However, secondary MHs had a lower closure rate (67% vs. 89%, p = 0.001) and less VA improvement (2 lines vs. 3 lines, p = 0.001) compared to idiopathic MHs. Significant differences in maximal basal diameter and diameter hole index were noted between the groups. Conclusions Secondary MHs, accounting for 11% of surgical cases, show poorer anatomical and visual outcomes than idiopathic MHs. Despite lower success rates, early surgical intervention in secondary MHs is recommended to enhance outcomes. Differentiating between idiopathic and secondary MHs is crucial for optimal management.

Let Y (+) be a group, D ⊆ ℤ2 where ℤ(+, ⩽) denotes the ordered group of all integers, and ℤ2 := ℤ×ℤ. We shall use the notations Dx := {u ∈ ℤ | ∃v ∈ X : (u, v) ∈ D}, Dy := {v ∈ ℤ | ∃u ∈ ℤ : (u, v) ∈ D}, Dx+y := {z ∈ ℤ | ∃(u, v) ∈ D : z = u + v}. The main purpose of the article is to find sets D ⊆ ℤ2 that the general solution of the functional equation f (x+y) = g(x)+h(y) for all (x, y) ∈ D with unknown functions f : Dx+y → Y, g : Dx → Y, h : Dy → Y is in the form of f (u) = a(u) + C1 + C2 for all u ∈ Dx+y, g(v) = a(v) + C1 for all v ∈ Dx, h(z) = a(z) + C2 for all z ∈ Dy where a : ℤ → Y is an additive function, C1, C2 ∈ Y are constants.

Anti-microbial stewardship program (AMSP) is practiced only in tertiary hospitals in India, though, the lower tier hospitals remain the first point of contact in patient care. This study was conducted in lower tier hospitals to calculate antibiotic and multiple antibiotic prescription rate (APR, MPR) for common infections and finding existing strength of health system for optimizing antibiotic prescription. We conducted a cross sectional convergent parallel mix-method study in eight lower tier hospitals of three districts of West Bengal, India. Six hundred OPD prescriptions of UTI, ARI, AUFI, ADD were evaluated. Qualitative data collected through in-depth interviews of medical officers/officers in administrative positions, infection control nurses were analyzed using content analysis method. APR was 63.8% in primary tier hospitals and 60.8% in secondary tier hospitals. The MPR was higher in secondary tier hospital (23.8%). Presence of infection control committee, designated nursing staff, initiation of prescription audit, increased monitoring were identified as few facilitators for future implementation of AMSP in lower tier hospitals. The routine infection control activities of lower tier hospitals are currently delinked from AMR containment measures and thus, customized AMSP needs to be established in these hospitals catering two third of the population of India. [ABSTRACT FROM AUTHOR]

The states of Oregon and Connecticut and the District of Columbia in the USA mandate the teaching of menstrual education which means the teachers of students with disabilities are expected to be familiar with the topics of hygiene, self-care, and independent living skills in relation to menstrual health needs. Special education teachers may need to attend to pre-menstrual symptoms, collect data on challenging behaviour, and ensure their students have access to period products. Teachers can consult with parents about teaching these skills at home to ensure generalisation of skills across contexts, and to build strong communication between school and home. Teachers should also familiarise themselves with local resources for menstrual supplies and instructional materials for both students and parents. Teaching skills in relation to menstrual health is critical for increasing independence, maintaining individual dignity, and fostering a menstrual experience free of stigma and shame. [ABSTRACT FROM AUTHOR]

Viewing teacher vulnerability as a pedagogical tool, this comparative case study examined two secondary literacy teachers' use of vulnerability in relation to various instructional goals. Through the analysis of eight video‐recorded lessons, we found that teachers demonstrated vulnerability through multiple ways within their literacy instruction through modeling ways of connecting personal experiences to texts, and establishing classroom norms that welcome difficult emotions and experiences. However, we also found that teacher vulnerability can sometimes lead to uncertainty, and even constrain student participation. We argue that teacher vulnerability helps establish a humanizing pedagogy, and offer possible strategies for teachers who are vulnerable within literacy instruction. We conclude with a discussion of different levels of appropriating vulnerability as a pedagogical tool. [ABSTRACT FROM AUTHOR]

Copyright of Natural Gas Geoscience is the property of Natural Gas Geoscience and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To identify the risk factors of postoperative severe hyperkalemia after total parathyroidectomy (TPTX) without auto-transplantation in patients with secondary hyperparathyroidism (SHPT). Methods: Data on 406 consecutive patients who underwent TPTX without auto-transplantation for secondary hyperparathyroidism at the General Hospital of Northern Theater Command between January 2013 and January 2023, were prospectively collected. Then, patients were divided into the training set (n=203) and the validation set (n=203) in a ratio of 1:1 by timeline. The patients were divided into severe hyperkalemia group and non-hyperkalemia group according to the postoperative serum kalium level >6.0 mmol/L with ECG changes or serum kalium level ≥6.5 mmol/L. Univariate and multivariate logistic regression analyses were used to evaluate the possible risk factors associated with postoperative severe hyperkalemia after TPTX. The predictive performance was evaluated with receiver operating characteristic (ROC) curves with the areas under the ROC curve (AUC) and calibration curve. Decision curve and clinical impact curve analyses were used to validate the clinical application of the value. Results: The incidence of postoperative severe hyperkalemia was 15.5% in all patients, 17.2% and 13.8% in the training and validation cohorts, respectively. The risk factors associated with postoperative severe hyperkalemia was higher preoperative kalium level. The optimal cut-off value for preoperative serum kalium level was 5.0mmol/L according to the ROC curve. The area under the curve (AUC) achieved good concordance indexes of 0.845 (95%CI, 0.776-0.914) in the training cohort. The sensitivities were 0.829 (95%CI: 0.663-0.934) and 0.857 (95%CI: 0.673-0.960) in the training and validation cohorts, respectively. The specificities were 0.798 (95%CI: 0.729-0.856) and 0.720 (95%CI:0.647-0.785) in the training and validation cohorts, respectively. Calibration curve exhibited a good consistency between actual observations and predicted severe hyperkalemia in the training and validation cohorts. Conclusions: Our study found that the preoperative kalium levels is only a risk factor for postoperative severe hyperkalemia in patients undergoing TPTX for secondary hyperparathyroidism. The threshold for preoperative serum kalium levels is 5.0mmol/L that can serve as a useful indicator for identifying patients with severe hyperkalemia after surgery. These results provide valuable suggestion for clinical practice. [ABSTRACT FROM AUTHOR]

Purpose: This study aimed to compare demographics, clinical characteristics, and post-surgical outcomes between idiopathic and secondary full-thickness macular holes (MHs). Methods: A retrospective analysis of 348 eyes from 339 patients treated between June 2017 and December 2023 was conducted. The study included both idiopathic and secondary MHs, excluding cases where surgery was not performed or lacked sufficient follow-up. Demographic data, visual acuity (VA), ocular characteristics, and optical coherence tomography measurements were analyzed. Results: Idiopathic MHs were identified in 308 eyes (89%), and secondary MHs in 40 eyes (11%). Idiopathic MH patients were older (mean age: 68.26 vs. 60.13 years; p = 0.001) and more commonly female (63% vs. 40%; p = 0.005). Post-surgical closure was achieved in 86% of all MHs, with a median VA improvement of 15 ETDRS letters (3 Snellen lines). However, secondary MHs had a lower closure rate (67% vs. 89%, p = 0.001) and less VA improvement (2 lines vs. 3 lines, p = 0.001) compared to idiopathic MHs. Significant differences in maximal basal diameter and diameter hole index were noted between the groups. Conclusions: Secondary MHs, accounting for 11% of surgical cases, show poorer anatomical and visual outcomes than idiopathic MHs. Despite lower success rates, early surgical intervention in secondary MHs is recommended to enhance outcomes. Differentiating between idiopathic and secondary MHs is crucial for optimal management. [ABSTRACT FROM AUTHOR]

This study aims to determine the motivation of indigenous students in learning Filipino in public schools. There were 10 participants in this study from Francisco Bangoy High School. After the questionnaire was prepared, interviews were conducted and the responses of the participants were analyzed. The design used in the study was quantitative research. In connection with this, data analysis using the Collaizi method and qualitative phenomenological research were employed by the researcher to describe the lived experiences of a person in an event. The participants in the study were selected indigenous students in public schools. Additionally, the result of the study was to find out the motivation of indigenous students in their studies. Conducting further research about the motivation of indigenous students is recommended to ensure their needs are met. And, to identify the obstacles affecting the learning of Filipino by indigenous students. The study recommended that attention should be given to research concerning the motivation of indigenous students to change the public's perception of indigenous students. [ABSTRACT FROM AUTHOR]

Background: Secondary schools are important settings for promoting varied physical activity (PA) opportunities for adolescents to promote PA throughout life. However, research on the effect of secondary school-based interventions on future PA is limited. This study examined the potential impact of secondary school-based interventions on the determinants of future PA participation of Aotearoa New Zealand (NZ) adolescents using simulated modelling. Methods: We used data from a nationally representative sample of secondary school students (n = 5035) aged 12–17 between 2017 and 2020 in NZ. We modelled four secondary school-based interventions and their projected impact on five determinants of future PA. Modelled interventions were the technological augmentation of physical education (TAPE), a peer-led PA mentoring programme (PL), physically active learning (PAL) and the inclusion of a natural environment play area (NE). Results: Total weekly PA increased the most from the NE intervention (+ 0.2 h/week), followed by TAPE (+ 0.08 h/week), PAL (+ 0.05 h/week) and PL (-0.06 h/week). Current number of PA settings increased the most in NE (+ 1.75 settings/week), followed by TAPE (+ 1.29 settings/week), PAL (+ 1.21 settings/week) and PL (+ 0.73 settings/week). Current number of PA types increased the most in NE (+ 1.57 types/week), followed by PL (+ 1.05 types/week), TAPE (+ 0.34 types/week) and PAL (+ 0.15 types/week). Physical literacy scores increased the most from PL (+ 3.6%), followed by PAL (+ 3.3%), TAPE (+ 0.43%) and NE (+ 0.12%). Social support scores increased the most from PAL (+ 5%), followed by PL (+ 1.9%), TAPE (+ 1.46%) and NE (+ 0.57%). Conclusions: On average, all interventions benefitted determinants of future PA participation to a small degree. Results show differing magnitudes of the intervention effect by determinant, indicating the complexities surrounding the promotion of PA adherence. Future interventions could be improved through detailed consultation alongside, and involving, adolescents and stakeholders within schools. Researchers should also prioritise the collection of longitudinal PA data and explore its connection with sociodemographic differences between adolescents. [ABSTRACT FROM AUTHOR]

The COVID-19 pandemic transformed education, driving students and teachers to adapt to digital platforms to facilitate the process of remote teaching and learning. This study aimed to analyze the relationship between self-regulated learning in virtual environments and the achievement of English competencies among second-grade secondary students at the "Tawantinsuyo" Emblematic Educational Institution in Desaguadero, Puno, Peru. Using a quantitative approach and a non-experimental descriptive-correlational design, the study included a sample of 115 students aged 13 to 14. For data collection, the Self-Regulated Learning Scale in Virtual Contexts and the Academic Year 2021 Report Card were administered. The data were processed through descriptive analysis, Chi-square tests, and the Spearman Rho correlation coefficient. The results indicated that 54.8% of students showed a moderate level of selfregulated learning, and 60% achieved the expected level of proficiency in English. Although the Spearman correlation revealed a weak but significant positive correlation, especially in writing (r = 0.231, p = 0.013), the Chi-square analysis did not show a statistically significant association. In conclusion, while students with better self-regulated learning in virtual environments tend to perform better in English, other factors may also be associated with their academic achievement. [ABSTRACT FROM AUTHOR]

Purpose: Risk factors (RFs), like 'body mass index (BMI),' 'age,' and 'gender' correlate with Diabetic Retinopathy (DR) diagnosis and have been widely studied. This study examines how these three secondary RFs independently affect the predictive capacity of primary RFs. Methods: The dataset consisted of four population-based studies on the prevalence of DR and associated RFs in India between 2001 and 2010. An Autoencoder was employed to categorize RFs as primary or secondary. This study evaluated six primary RFs coupled independently with each secondary RF on five machine-learning models. Results: The secondary RF 'gender' gave a maximum increase in Area under the curve (AUC) score to predict DR when combined separately with 'insulin treatment,' 'fasting plasma glucose,' 'hypertension history,' and 'glycosylated hemoglobin' with a maximum increase in AUC for the Naive Bayes model from 0.573 to 0.646, for the Support Vector Machines (SVM) model from 0.644 to 0.691, for the SVM model from 0.487 to 0.607, and for the Decision Tree model from 0.8 to 0.848, respectively. The secondary RFs 'age' and 'BMI' gave a maximum increase in AUC score to predict DR when combined separately with 'diabetes mellitus duration' and 'systolic blood pressure,' with a maximum increase in AUC for the SVM model from 0.389 to 0.621, and for the Decision Tree model from 0.617 to 0.713, respectively. Conclusion: The risk factor 'gender' was the best secondary RF in predicting DR compared to 'age' and 'BMI,' increasing the predictive power of four primary RFs. [ABSTRACT FROM AUTHOR]

In the paper entitled Comparative analysis of employed population and the gross domestic product in Romania and the RomanianWestern Region, by sectors of activity, the dynamics of employed population and gross domestic product before and during the pandemic, respectively the period 2016-2021 has been analysed. Based on the comparative analysis of the employed population in Romania and in the Western Region of the same country, for the period 2016-2018, a dynamic in the primary sector was found, a decrease in the secondary sector and an increase in the tertiary sector. In the period 2019-2021, the employed population, by sector of activity, decreased in the primary sector, was dynamic in the secondary sector and increasedin the tertiary sector. There are significant differences between the average percentages calculated for the WesternRegion compared to Romania, which shows a decrease in the employed population in the primary and tertiary sectors and an increase in the secondary. In terms of gross domestic product in current prices, over the entire period 2016-2021, Romania's gross domestic product by sectors of activity recorded an increase in the primary and tertiary sectors and a dynamic in the secondary sector. At the level of the Western Region, in the period 2016-2019, in all sectors of activity, the gross domestic product in current prices increased. Due to the emergence of the pandemic in 2020, there are decreases in GDP in current prices in all sectors of activity, but from 2021 onwards the economy recovers, so that its values increased both in Romania and in the Western Region. [ABSTRACT FROM AUTHOR]

We consider two multiplicative statistics on the set of integer partitions: the norm of a partition, which is the product of its parts, and the supernorm of a partition, which is the product of the prime numbers p i indexed by its parts i. We introduce and study new statistics that are sums of reciprocals of supernorms on three statistical ensembles of partitions, labelled by their size | λ | = n , their perimeter equaling n, and their largest part equaling n. We show that the cumulative statistics of the reciprocal supernorm for each of the three ensembles are asymptotic to e γ log n as n → ∞ . [ABSTRACT FROM AUTHOR]

Focal imaging abnormalities in patients with parkinsonism suggest secondary etiology and require a distinctive clinical approach to diagnosis and treatment. We review different entities presenting as secondary parkinsonism associated with structural brain lesions, with emphasis on the clinical course and neuroimaging findings. Secondary parkinsonism may be due to vascular causes, hydrocephalus, space-occupying lesions, metabolic causes (including acquired hepatocerebral degeneration, diabetic uremic encephalopathy, basal ganglia calcifications, osmotic demyelination syndrome), hypoxic-ischaemic brain injury, intoxications (including methanol, carbon monoxide, cyanide, carbon disulfide, manganese poisoning and illicit drugs), infections and immune causes. The onset can vary from acute to chronic. Both uni-and bilateral presentations are possible. Rigidity, bradykinesia and gait abnormalities are more common than rest tremor. Coexisting other movement disorders and additional associated neurological signs may point to the underlying diagnosis. Neuroimaging studies are an essential part in the diagnostic work-up of secondary parkinsonism and may point directly to the underlying etiology. We focus primarily on magnetic resonance imaging to illustrate how structural imaging combined with neurological assessment can lead to diagnosis. It is crucial that typical imaging abnormalities are recognized within the relevant clinical context. Many forms of secondary parkinsonism are reversible with elimination of the specific cause, while some may benefit from symptomatic treatment. This heterogeneous group of acquired disorders has also helped shape our knowledge of Parkinson's disease and basal ganglia pathophysiology, while more recent findings in the field garner support for the network perspective on brain function and neurological disorders. [ABSTRACT FROM AUTHOR]

Although COVID-19 infection is an immunosuppressant disease, many immunosuppressant agents, such as pulse methylprednisolone (PMP), dexamethasone (DXM), and tocilizumab (TCZ), were used during the pandemic. Secondary infections in patients with COVID-19 have been reported recently. This study investigated these agents' effects on secondary infections and outcomes in patients with COVID-19 in intensive care units (ICUs). This study was designed retrospectively, and all data were collected from the tertiary intensive care units of six hospitals between March 2020 and October 2021. All patients were divided into three groups: Group I [GI, PMP (−), DXM (−) and TCZ (−)], Group II [GII, PMP (+), DXM (+)], and Group III [GIII, PMP (+), DXM (+), TCZ (+)]. Demographic data, PaO/FiO2 ratio, laboratory parameters, culture results, and outcomes were recorded. To compare GI-GII and GI-GIII, propensity score matching (PSM) was used by matching 14 parameters. Four hundred twelve patients with COVID-19 in the ICU were included in the study. The number of patients with microorganisms ≥ 2 was 279 (67.7%). After PSM, in GII and GIII, the number of (+) tracheal cultures and (+) bloodstream cultures detected different microorganisms ≥ 2 during the ICU period, neuropathy, tracheotomized patients, duration of IMV, and length of ICU stay were significantly higher than GI. The mortality rate was similar in GI and GII, whereas it was significantly higher in GIII than in GI. The use of immunosuppressant agents in COVID-19 patients may lead to an increase in secondary infections. In addition, increased secondary infections may lead to prolonged ICU stay, prolonged IMV duration, and increased mortality. [ABSTRACT FROM AUTHOR]

Copyright of Revista Góndola, Enseñanza y Aprendizaje de las Ciencias is the property of Gondola, Ensenanza y Aprendizaje de las Ciencias and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)