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3. Role of body mass index in the prediction of all cause mortality in over 62,000 men and women. The Italian RIFLE Pooling Project. Risk Factor and Life Expectancy

Author

Seccareccia, F, Lanti, M, Menotti, A, Scanga, M, and Loria, Paola

Subjects
Adult, Male, Gerontology, systolic blood pressure, body mass index, mortality, RIFLE, smoking, age, Multivariate analysis, Epidemiology, Age adjustment, Population, Blood Pressure, Body Mass Index, Age Distribution, Humans, Medicine, Mortality, Sex Distribution, Risk factor, education, Aged, Proportional Hazards Models, education.field_of_study, business.industry, Proportional hazards model, Mortality rate, Smoking, Public Health, Environmental and Occupational Health, Articles, Middle Aged, Confidence interval, Italy, Multivariate Analysis, Female, business, Body mass index, Demography
Abstract

STUDY OBJECTIVE: To evaluate the relation of body mass index (BMI) to short-term mortality in a large Italian population sample. DESIGN: Within the Italian RIFLE pooling project, BMI was measured in 47 population samples made of 32,741 men and 30,305 women ages 20-69 years (young 20-44, mature 45-69). Data on mortality were collected for the next six years. MAIN OUTCOME MEASURES: Age adjusted death rates in quintile classes of BMI and Cox proportional hazards models with six year all causes mortality as end point, BMI as covariate and age, smoking, systolic blood pressure as possible confounders were computed. Multivariate analysis was tested in all subjects and after the exclusion of smokers, early (first two years) deaths, and both categories. RESULTS: The univariate analysis failed to demonstrate in all cases a U or inverse J shaped relation. The Cox coefficients for the linear and quadratic terms of BMI proved significant for both young and mature women. The minimum of the curve was located at 27.0 (24.0, 30.0, 95% confidence limits, CL) and 31.8 (25.5, 38.2, 95% CL) units of BMI, for young and mature women respectively. Similar findings were obtained even when exclusion were performed. No relation was found for young men while for mature adult men only the model for all subjects retained significant curvilinear relation (minimum 29.3; 22.4, 36.2, 95% CL). CONCLUSION: These uncommon high values of BMI carrying the minimum risk of death seems to be in contrast with weight guidelines. A confirmation of these findings in other population groups might induce the consideration of changes in the suggested healthy values of BMI.

Published
1998
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4. Role of body mass index in the prediction of all cause mortality in over 62000 men and women. The Italian RIFLE Pooling Project

Author

SECCARECCIA F, LANTI M, MENOTTI A, SCANGA M, THE RIFLE RESEARCH GROUP, FARCHI G, CONTI S, MARENCO G, FALCHERO M, FERRARIO M, CESANA GC, TENCONI MT, MUSSI A, DOBRILLA G, DE PETRIS G, ANGELINI GP, OCKOLICSANYI L, TOSO S, AMBROSIO GB, BITTOLO BON G, ALESSANDRINI P, FERUGLIO GA, VANUZZO D, CARULLI N, SALVIOLI GF, GADDI A, D'ADDARO S, ALVISI V, BUZZELLI GP, GIACCHI M, LAURENZI M, SPAGNOLO A, RICCI G, ANTONINI R, ANGELICO F, LALLONI L, ATTILI AF, URBINATI GC, GIAMPAOLI S, MANCINI M, PANICO S, FARINARO E, ALBANO O, MISCIAGNA G, MUNTONI S, STABILINI L, AVELLONE G, DI GARBO G., DEVOTI, Gabriele, Seccareccia, F, Lanti, M, Menotti, A, Scanga, M, THE RIFLE RESEARCH, Group, Farchi, G, Conti, S, Marenco, G, Falchero, M, Ferrario, M, Cesana, Gc, Tenconi, Mt, Mussi, A, Devoti, Gabriele, Dobrilla, G, DE PETRIS, G, Angelini, Gp, Ockolicsanyi, L, Toso, S, Ambrosio, Gb, BITTOLO BON, G, Alessandrini, P, Feruglio, Ga, Vanuzzo, D, Carulli, N, Salvioli, Gf, Gaddi, A, D'Addaro, S, Alvisi, V, Buzzelli, Gp, Giacchi, M, Laurenzi, M, Spagnolo, A, Ricci, G, Antonini, R, Angelico, F, Lalloni, L, Attili, Af, Urbinati, Gc, Giampaoli, S, Mancini, M, Panico, S, Farinaro, E, Albano, O, Misciagna, G, Muntoni, S, Stabilini, L, Avellone, G, and DI GARBO, G.

Published
1998

5. Electrocardiographic Minnesota Code findings predicting short-term mortality in asymptomatic subjects. The Italian RIFLE Pooling Project (Risk Factors and Life Expectancy)

Author

MENOTTI A, SECCARECCIA F, THE RIFLE RESEARCH GROUP, LANTI M, FARCHI G, CONTI S, DIMA F, SCANGA M, MARENCO G, FALCHERO M, FERRARIO M, CESANA GC, TENCONI MT, LADDOMADA MS, DOBRILLA G, DE PETRIS G, ANGELINI GP, OCKOLICSANYI L, TOSO S, AMBROSIO GB, BITTOLO BON G, ALESSANDRINI P, FERUGLIO GA, VANUZZO D, CARULLI N, SALVIOLI GF, GADDI A, D'ADDATO S, ALVISI V, BUZZELLI GP, GIACCHI M, LAURENZI M, SPAGNOLO A, RICCI G, ANTONINI R, ANGELICO F, LALLONI L, ATTILI AF, URBINATI GC, GIAMPAOLI S, MANCINI M, PANICO S, FARINARO E, ALBANO O, MISCIAGNA G, MUNTONI S, STABILINI L, AVELLONE G, DI GARBO G. ., DEVOTI, Gabriele, Menotti, A, Seccareccia, F, THE RIFLE RESEARCH, Group, Lanti, M, Farchi, G, Conti, S, Dima, F, Scanga, M, Marenco, G, Falchero, M, Ferrario, M, Cesana, Gc, Tenconi, Mt, Laddomada, M, Devoti, Gabriele, Dobrilla, G, DE PETRIS, G, Angelini, Gp, Ockolicsanyi, L, Toso, S, Ambrosio, Gb, BITTOLO BON, G, Alessandrini, P, Feruglio, Ga, Vanuzzo, D, Carulli, N, Salvioli, Gf, Gaddi, A, D'Addato, S, Alvisi, V, Buzzelli, Gp, Giacchi, M, Laurenzi, M, Spagnolo, A, Ricci, G, Antonini, R, Angelico, F, Lalloni, L, Attili, Af, Urbinati, Gc, Giampaoli, S, Mancini, M, Panico, S, Farinaro, E, Albano, O, Misciagna, G, Muntoni, S, Stabilini, L, Avellone, G, and DI GARBO, G. .

Published
1997

6. Syndrome X: prevalence in a large population-based study

Author

LIU J, TREVISAN M, MENOTTI A, THE RIFLE RESEARCH GROUP, LANTI M, FARCHI G, CONTI S, SECCARECCIA F, DIMA F, SCANGA M, MARENCO G, FALCHERO M, FERRARIO M, CESANA GC, TENCONI MT, LADDOMADA MS, DOBRILLA G, DE PETRIS G, ANGELINI GP, OCKOLICSANYI L, TOSO S, AMBROSIO GB, BITTOLO BON G, ALESSANDRINI P, FERUGLIO GA, VANUZZO D, CARULLI N, SALVIOLI GF, GADDI A, D'ADDARO S, ALVISI V, BUZZELLI GP, GIACCHI M, LAURENZI M, SPAGNOLO A, RICCI G, ANTONINI R, ANGELICO F, LALLONI L, ATTILI AF, URBINATI GC, GIAMPAOLI S, MANCINI M, PANICO S, FARINARO E, ALBANO O, MISCIAGNA G, MUNTONI S, STABILINI L, AVELLONE G, DI GARBO G. ., DEVOTI, Gabriele, Liu, J, Trevisan, M, Menotti, A, THE RIFLE RESEARCH, Group, Lanti, M, Farchi, G, Conti, S, Seccareccia, F, Dima, F, Scanga, M, Marenco, G, Falchero, M, Ferrario, M, Cesana, Gc, Tenconi, Mt, Laddomada, M, Devoti, Gabriele, Dobrilla, G, DE PETRIS, G, Angelini, Gp, Ockolicsanyi, L, Toso, S, Ambrosio, Gb, BITTOLO BON, G, Alessandrini, P, Feruglio, Ga, Vanuzzo, D, Carulli, N, Salvioli, Gf, Gaddi, A, D'Addaro, S, Alvisi, V, Buzzelli, Gp, Giacchi, M, Laurenzi, M, Spagnolo, A, Ricci, G, Antonini, R, Angelico, F, Lalloni, L, Attili, Af, Urbinati, Gc, Giampaoli, S, Mancini, M, Panico, S, Farinaro, E, Albano, O, Misciagna, G, Muntoni, S, Stabilini, L, Avellone, G, and DI GARBO, G. .

Published
1997

7. Mean levels and distributions of some cardiovascular risk factors in Italy in the 1970's and the 1980's. The Italian RIFLE Pooling Project. Risk Factors and Life Expectancy

Author

MENOTTI A, SECCARECCIA F, LANTI M, THE RIFLE PROJECT RESEARCH GROUP, FARCHI G, CONTI S, DIMA F, SCANGA M, MARENCO G, FALCHERO M, IDEO G, PODDA M, FERRARIO M, CESANA GC, TENCONI MT, MUSSI A, DOBRILLA G, DE PETRIS G, ANGELINI GP, OCKOLICSANYI L, TOSO S, AMBROSIO GB, BITTOLO BON G, ALESSANDRINI P, FERUGLIO GA, VANUZZO D, CARULLI N, SALVIOLI GF, GADDI A, D'ADDARO S, ALVISI V, BUZZELLI GP, GIACCHI M, LAURENZI M, SPAGNOLO A, RICCI G, ANTONINI R, ANGELICO F, LALLONI L, ATTILI AF, URBINATI GC, GIAMPAOLI S, MANCINI M, PANICO S, FARINARO E, ALBANO O, MISCIAGNA G, MUNTONI S, STABILINI L, AVELLONE G, DI GARBO G. ., DEVOTI, Gabriele, Menotti, A, Seccareccia, F, Lanti, M, THE RIFLE PROJECT RESEARCH, Group, Farchi, G, Conti, S, Dima, F, Scanga, M, Marenco, G, Falchero, M, Ideo, G, Podda, M, Ferrario, M, Cesana, Gc, Tenconi, Mt, Mussi, A, Devoti, Gabriele, Dobrilla, G, DE PETRIS, G, Angelini, Gp, Ockolicsanyi, L, Toso, S, Ambrosio, Gb, BITTOLO BON, G, Alessandrini, P, Feruglio, Ga, Vanuzzo, D, Carulli, N, Salvioli, Gf, Gaddi, A, D'Addaro, S, Alvisi, V, Buzzelli, Gp, Giacchi, M, Laurenzi, M, Spagnolo, A, Ricci, G, Antonini, R, Angelico, F, Lalloni, L, Attili, Af, Urbinati, Gc, Giampaoli, S, Mancini, M, Panico, S, Farinaro, E, Albano, O, Misciagna, G, Muntoni, S, Stabilini, L, Avellone, G, and DI GARBO, G. .

Published
1995

9. The prediction of coronary heart disease mortality as a function of major risk factors in over 30000 men in the Italian RIFLE Pooling Project. A comparison with the MRFIT primary screenees

Author

MENOTTI A, FARCHI G, SECCARECCIA F, THE RIFLE RESEARCH GROUP, CONTI S, GIAMPAOLI S, LANTI M, MARIOTTI S, SCANGA M, MARENCO G, FALCHERO M, IDEO G, PODDA M, FERRARIO M, CESANA GC, TENCONI MT, LADDOMADA MS, DOBRILLA G, DE PETRIS G, ANGELINI GP, OCKOLICSANYI L, TOSO S, AMBROSIO GB, BITTOLO BON G, ALESSANDRINI P, FERUGLIO GA, VANUZZO D, CARULLI N, SALVIOLI GF, GADDI A, D'ADDARO S, ALVISI V, BUZZELLI GP, GIACCHI M, LAURENZI M, SPAGNOLO A, RICCI G, ANTONINI R, ANGELICO F, LALLONI L, ATTILI AF, URBINATI GC, MANCINI M, PANICO S, FARINARO E, ALBANO O, MISCIAGNA G, MUNTONI S, STABILINI L, AVELLONE G, DI GARBO G. ., DEVOTI, Gabriele, Menotti, A, Farchi, G, Seccareccia, F, THE RIFLE RESEARCH, Group, Conti, S, Giampaoli, S, Lanti, M, Mariotti, S, Scanga, M, Marenco, G, Falchero, M, Ideo, G, Podda, M, Ferrario, M, Cesana, Gc, Tenconi, Mt, Laddomada, M, Devoti, Gabriele, Dobrilla, G, DE PETRIS, G, Angelini, Gp, Ockolicsanyi, L, Toso, S, Ambrosio, Gb, BITTOLO BON, G, Alessandrini, P, Feruglio, Ga, Vanuzzo, D, Carulli, N, Salvioli, Gf, Gaddi, A, D'Addaro, S, Alvisi, V, Buzzelli, Gp, Giacchi, M, Laurenzi, M, Spagnolo, A, Ricci, G, Antonini, R, Angelico, F, Lalloni, L, Attili, Af, Urbinati, Gc, Mancini, M, Panico, S, Farinaro, E, Albano, O, Misciagna, G, Muntoni, S, Stabilini, L, Avellone, G, and DI GARBO, G. .

Published
1994

10. Presentation of the RIFLE Project Risk Factors and Life Expectancy

Author

THE RIFLE RESEARCH GROUP, MENOTTI A, FARCHI G, CONTI S, GIAMPAOLI S, LANTI M, MARIOTTI S, SCANGA M, SECCARECCIA F, SPAGNOLO A, VERDECCHIA A, DI CARLO G, DIMA F, MARENCO G, FALCHERO M, IDEO G, PODDA M, FERRARIO M, CESANA GC, TENCONI MT, LADDOMADA MS, DOBRILLA G, DE PETRIS G, ANGELINI GP, OCKOLICSANYI L, TOSO S, AMBROSIO GB, TASSO S, BITTOLO BON G, ALESSANDRINI P, FERUGLIO GA, VANUZZO D, CARULLI N, SALVIOLI GF, GADDI A, D'ADDATO S, DESCOVICH GC, DORMI A, BARBARA L, ALVISI V, BUZZELLI GP, GIACCHI M, LAURENZI M, RICCI G, ANTONINI R, ANGELICO F, LALLONI L, ATTILI AF, URBINATI GC, MANCINI M, PANICO S, FARINARO E, ALBANO O, MISCIAGNA G, MUNTONI S, STABILINI L, AVELLONE G, DI GARBO G. ., DEVOTI, Gabriele, THE RIFLE RESEARCH, Group, Menotti, A, Farchi, G, Conti, S, Giampaoli, S, Lanti, M, Mariotti, S, Scanga, M, Seccareccia, F, Spagnolo, A, Verdecchia, A, DI CARLO, G, Dima, F, Marenco, G, Falchero, M, Ideo, G, Podda, M, Ferrario, M, Cesana, Gc, Tenconi, Mt, Laddomada, M, Devoti, Gabriele, Dobrilla, G, DE PETRIS, G, Angelini, Gp, Ockolicsanyi, L, Toso, S, Ambrosio, Gb, Tasso, S, BITTOLO BON, G, Alessandrini, P, Feruglio, Ga, Vanuzzo, D, Carulli, N, Salvioli, Gf, Gaddi, A, D'Addato, S, Descovich, Gc, Dormi, A, Barbara, L, Alvisi, V, Buzzelli, Gp, Giacchi, M, Laurenzi, M, Ricci, G, Antonini, R, Angelico, F, Lalloni, L, Attili, Af, Urbinati, Gc, Mancini, M, Panico, S, Farinaro, E, Albano, O, Misciagna, G, Muntoni, S, Stabilini, L, Avellone, G, and DI GARBO, G. .

Published
1993

12. PRESENTATION OF THE RIFLE PROJECT RISK-FACTORS AND LIFE EXPECTANCY

Author

Menotti, A., Farchi, G., Conti, S., Giampaoli, S., Lanti, M., Mariotti, S., Scanga, M., Seccareccia, F., Spagnolo, A., Verdecchia, A., Dicarlo, G., Dima, F., Marenco, G., Falchero, M., Ideo, G., Caspani, B., Podda, M., Zuin, M., Ferrario, M., Cesana, Gc, Devito, G., Sega, R., Tenconi, Mt, Laddomada, Ms, Devoti, G., Dobrilla, G., Depetris, G., Angelini, Gp, Okolicsanyi, L., Toso, S., Nassuato, G., Passera, D., Ambrosio, Gb, Tasso, S., Bittolobon, G., Moro, E., Alessandrini, P., Soldan, S., Feruglio, Ga, Vanuzzo, D., Pilotto, L., Carulli, N., Loria, P., Dilengite, M., Bozzoli, M., Salvioli, Gf, Lugli, R., Gaddi, A., Sangiorgi, Z., Daddato, S., Minardi, A., Descovich, Gc, Dormi, A., Barbara, L., Festi, D., Alvisi, V., Balhous, W., Buzzelli, Gp, Giusti, A., Giacchi, M., Fatighenti, D., Giotti, M., Laurenzi, M., Ricci, G., Bucci, A., Antonini, R., Pacioni, F., Angelico, F., Delben, M., Lalloni, L., Azzarri, L., Ricci, P., Attili, Fa, Desantis, A., Urbinati, Gc, Fazio, S., Pannozzo, F., Sotis, Gl, Righetti, Gm, Mancini, M., Farinaro, E., Panico, S., Trevisan, M., Krogh, V., Jossa, F., Celentano, E., Rocco Galasso, Albano, O., Palasciano, G., Misciagna, G., Guerra, V., Muntoni, S., Pintus, P., Podda, E., Stabilini, M., Frulio, T., Brotzu, G., Pulina, S., Trudu, A., Sanna, A., Baule, Gm, Avellone, G., and Digarbo, V.

Subjects
RISK FACTORS, LIFE EXPECTANCY, MORTALITY, PREDICTION
Published
1993

14. Role of body mass index in the prediction of all cause mortality in over 62 000 men and women. The Italian RIFLE Pooling Project

Author

Seccareccia, F., Scanga, M., Lanti, M., Menotti, A., and Group, RIFLE Research

Abstract

Study objectiveTo evaluate the relation of body mass index (BMI) to short-term mortality in a large Italian population sample.DesignWithin the Italian RIFLE pooling project, BMI was measured in 47 population samples made of 32 741 men and 30 305 women aged 20-69 years (young 20-44, mature 45-69). Data on mortality were collected for the next six years.Main outcome measuresAge adjusted death rates in quintile classes of BMI and Cox proportional hazards models with six year all causes mortality as end point, BMI as covariate and age, smoking, systolic blood pressure as possible confounders were computed. Multivariate analysis was tested in all subjects and after the exclusion of smokers, early (first two years) deaths, and both categories.ResultsThe univariate analysis failed to demonstrate in all cases a U or inverse J shaped relation. The Cox coefficients for the linear and quadratic terms of BMI proved significant for both young and mature women. The minimum of the curve was located at 27.0 (24.0, 30.0, 95% confidence limits, CL) and 31.8 (25.5, 38.2, 95% CL) units of BMI, for young and mature women respectively. Similar findings were obtained even when exclusion were performed. No relation was found for young men while for mature adult men only the model for all subjects retained significant curvilinear relation (minimum 29.3; 22.4, 36.2, 95% CL).ConclusionThese uncommon high values of BMI carrying the minimum risk of death seems to be in contrast with weight guidelines. A confirmation of these findings in other population groups might induce the consideration of changes in the suggested healthy values of BMI.

Published
1998

18. Serum triglycerides in the prediction of coronary artery disease (an Italian experience).

Author

Menotti A, Scanga M, and Morisi G

Subjects
Age Factors, Cholesterol, HDL blood, Cholesterol, LDL blood, Coronary Disease blood, Coronary Disease mortality, Humans, Italy, Logistic Models, Male, Middle Aged, Multivariate Analysis, Predictive Value of Tests, Proportional Hazards Models, Coronary Disease diagnosis, Triglycerides blood
Abstract

An occupational group living in Rome and composed of 3,007 men aged 46 to 65 years who were free from previous major coronary events was screened for a number of coronary risk factors and then followed up for 10 years. In all, 107 coronary deaths occurred in 10 years. There was a positive relation between coronary death rate and increasing levels of triglycerides, but the difference between the extreme quintile classes was not any more significant after adjustment for cholesterol levels. A cross-classification involving low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglyceride levels showed a higher coronary artery disease (CAD) mortality in subjects with a higher LDL cholesterol/HDL cholesterol ratio and higher triglycerides. However, the excess risk in this subgroup was largely explained by the mean levels of total cholesterol. The multivariate proportional-hazards Cox model with coronary deaths as the end point, and age and triglycerides as predictors, produced a significant coefficient for triglycerides that became nonsignificant when other lipids alone or in combination (total, HDL and LDL cholesterol and some of their ratio) were fed into the model as further covariates. It is concluded that there is no evidence of an independent role of triglycerides in the prediction of coronary deaths.

Published
1994
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19. [Treatment of smoking in myocardial infarction survivors].

Author

Menotti A and Scanga M

Subjects
Humans, Myocardial Infarction epidemiology, Myocardial Infarction etiology, Recurrence, Risk Factors, Smoking adverse effects, Survivors, Myocardial Infarction prevention & control, Smoking therapy, Smoking Cessation
Abstract

Cigarette smoking is a well known primary risk factor of myocardial infarction. Many studies have shown that it is also a secondary risk factor able to predict the short and medium term occurrence of reinfarction and mortality. A number of observational studies suggest that patients who survive a first myocardial infarction have a halved risk of dying or of recurrence as compared to those who continue to smoke. Presently it is estimated that about 80% of smokers surviving a myocardial infarction quit smoking in short time. The intervention against smoking habits must be primarily conducted using advice and psychological means by the physician, with the help of other health personnel and of the social support of the family and friends.

Published
1993

20. Multivariate prediction of coronary deaths in a 10 year follow-up of an Italian occupational male cohort.

Author

Menotti A, Spagnolo A, Scanga M, and Dima F

Subjects
Cohort Studies, Coronary Disease epidemiology, Follow-Up Studies, Humans, Male, Multivariate Analysis, Prognosis, Risk Factors, Rome epidemiology, Coronary Disease mortality, Occupations statistics & numerical data
Abstract

3395 men aged 46-65 belonging to occupational groups in Rome were examined in 1980 for the measurement of a number of potential coronary risk factors and of other personal characteristics. They represented the 76.5% of the enrolled roster. In 2853 men free from previous major coronary events and with all the measurements available, 98 died from CHD in the next 10 years. The multivariate analysis performed by the Cox model showed the significant predictive role of age, systolic blood pressure, non-HDL cholesterol, blood glucose and heart rate. The relative risk (for a distance of 2 standard deviations from the mean) was of 2.3, 2.1, 1.4, 1.7 and 1.4 respectively. Smoking habits, body mass index, xanthelasma, leisure physical activity, serum triglycerides, uric acid and a stress score did not contribute to the prediction of coronary deaths. HDL cholesterol produced a negative but not significant coefficient. As compared to the previously available Italian risk functions the role of non-HDL cholesterol and of blood glucose represents the most remarkable contribution.

Published
1992

21. The Plasmodium vaughani--Complex.

Author

Corradetti A and Scanga M

Subjects
Animals, Birds, Blood microbiology, Culex, Erythrocytes microbiology, Hybridization, Genetic, Malaria, Avian etiology, Malaria, Avian microbiology, Plasmodium isolation & purification, Plasmodium pathogenicity, Time Factors, Plasmodium classification
Published
1973
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