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This PhD dissertation presents a profound study of the vulnerability of buildings and non-structural elements stemming from the investigation of the Mw 5.2 Lorca 2011 earthquake; which constitutes one of the most significant earthquakes in Spain. It left nine fatalities due to falling debris from reinforced concrete buildings, 394 injured and material damage valued at 800 million euros. Within this framework, the most relevant initiatives concerning the vulnerability of buildings and the exposure of Lorca are studied. This work revealed two lines of research: the elaboration of a rational method to determine the adequacy of a specific fragility curve for the particular seismic risk study of a region; and the relevance of researching the seismic performance of non-structural elements. As a consequence, firstly, a method to assess and select fragility curves for seismic risk studies from the catalogue of those available in the literature is elaborated and calibrated by means of a case study. The said methodology is based on a multidimensional index and provides a ranking that classifies the curves in terms of adequacy. Its results for the case of Lorca led to the elaboration of new fragility curves for unreinforced masonry buildings. Moreover, a simplified method to account for the unpredictable directionality of the seism in the creation of fragility curves is contributed. Secondly, the characterisation of the seismic capacity and demand of the non-structural elements that caused most of the human losses is studied. Concerning the capacity, an analytical approach derived from theoretical considerations to characterise the complete out-of-plane seismic response curve of unreinforced masonry cantilever walls is provided; as well as a simplified and more practical trilinear version of it. Concerning the demand, several methods for characterising the Floor Response Spectra of reinforced concrete buildings are tested through case studies.

The topic of seismic loss assessment not only incorporates many aspects of the earthquake engineering, but also entails social factors, public policies and business interests. Because of its multidisciplinary character, this process may be complex to challenge, and sound discouraging to neophytes. In this context, there is an increasing need of deriving simplified methodologies to streamline the process and provide tools for decision-makers and practitioners. This dissertation investigates different possible applications both in the area of modelling of seismic losses, both in the analysis of observational seismic data. Regarding the first topic, the PRESSAFE-disp method is proposed for the fast evaluation of the fragility curves of precast reinforced-concrete (RC) structures. Hence, a direct application of the method to the productive area of San Felice is studied to assess the number of collapses under a specific seismic scenario. In particular, with reference to the 2012 events, two large-scale stochastic models are outlined. The outcomes of the framework are promising, in good agreement with the observed damage scenario. Furthermore, a simplified displacement-based methodology is outlined to estimate different loss performance metrics for the decision-making phase of the seismic retrofit of a single RC building. The aim is to evaluate the seismic performance of different retrofit options, for a comparative analysis of their effectiveness and the convenience. Finally, a contribution to the analysis of the observational data is presented in the last part of the dissertation. A specific database of losses of precast RC buildings damaged by the 2012 Earthquake is created. A statistical analysis is performed, allowing deriving several consequence functions. The outcomes presented may be implemented in probabilistic seismic risk assessments to forecast the losses at the large scale. Furthermore, these may be adopted to establish retrofit policies to prevent and reduce

Aggregate masonry buildings have been generated over the years, allowing the interaction of different aggregated structural units under seismic action. The first part of this work is focused on the seismic vulnerability and fragility assessment of clay brick masonry buildings, sited in Bologna (Italy), with reference, at first, to single isolated structural units, by means of the Response Surface statistical method, taking into account some variabilities and uncertainties involved in the problem. The seismic action was defined by means of a group of selected registered accelerograms, in order to analyse the effect of the variability of the earthquakes. Identical and different structural units chosen by the Response Surface generated simulations are then aggregated in row, in order to compare the collapse PGA referred to the isolated structural unit and the one referred to the aggregate structure. The second part is focused on the seismic vulnerability and fragility assessment of stone masonry structures, sited in Seixal (Portugal), applying a methodology similar to that used for the buildings sited in Bologna. Since the availability of several information, the analyses involved the assessment of the most prevalent structural typologies in the area, considering the variability of a set of structural and geometrical parameters. The results highlighted the importance of the statistic procedures as method able to consider the variabilities and the uncertainties involved in the problem of the fragility of unreinforced masonry structures, in absence of accurate investigations on the structural typologies, as in the Seixal case study. Furthermore, it was showed that the structural units along the unreinforced clay brick or stone masonry aggregates cannot be analysed as isolated, as they are affected by the effect of the aggregation with adjacent structural units, according to the different directions of the seismic action considered and to their different position along th