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In 82 patients from 20--35 years of age with vegetative-vascular dystonia the authors studied clinical variants of the disease, the bioelectrical brain activity, the state of cerebral circulation, the visual analyzer, the cardiovascular system, histamine, protein, lipid, carbohydrate metabolism and the state of coagulative blood system. In the majority of the cases the studies demonstrated hystaminemia, some shifts in the biochemical blood content, an increased brain vascular tone, a drop of blood repletion and disturbances of regional hemodynamics. The studies also depicted a decreased functional lability of the main cortical bioelectrical processes, disturbances of electric activity and propulsive possibilities of the myocardium. It was also possible to demonstrate intercorrelation between the biochemical and electrophysiological indices with the type and form of the disease. It is assumed that the leading role in the pathogenesis of the disease belongs to the dysfunction of the limbico-reticular complex. Certain recommendations for normalization of the histamine metabolism are given as well as for the normalization of the reticulo-hypothalamic system functions. The authors also indicate a necessity of an early screening of the patients with vegetative-vascular dystonia.

In 160 patients with disorders of brain circulation in cerebral atherosclerosis, 68 normals and 38 patients with different neurological diseases (a control group), a special study was undertaken to study the antibrain antibodies with the aid of a complement fixation test (CFT), and a test of complement utilization (CUT). Positive results in the CFT and CUT were seen in patients with ischemic strokes and transient disorders of brain circulation. The formation of antibodies to brain tissues depends upon their type, duration of the disease and is more characteristic of the rehabilitation period. In studying autoimmune processes in patients with disordered brain circulation previous diseases should be taken into consideration (brain trauma, epilepsy, strokes). The existence of antibrain antibodies correlates with the intensity of the process.

The authors conducted a study of the histamine system (H), diaminoxidase (DO), histaminopexic index (HPI) using the biological method in 127 patients with hypertensive disease and cerebral atherosclerosis with brain circulation disturbances and in 23 patients with atherosclerotic parkinsonism. It was displayed that in the majority of the patients the H level and HPI value were pathologically changed, but DO activity was disturbed to a lesser degree. The authors demonstrated some correlations between the fluctuations of H-DO-HPI system and the character of the brain circulation disturbances, the period of the stroke, severity of the disease and an etiological factor. According to the authors' opinion changes in H-DO-HPI system were in a direct correlation with fluctuations of the level in the biological fluids of catecholimes, serotonin, acetylcholine, glucocorticoids. Recommendations concerning a discontinuation of histaminemia or its negative effects were given.