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Cardiac dysfunction in thyrotoxicosis is believed to arise from changes in preload, afterload, heart rate, and contractility. Cardiomyopathy is a less frequent cardiac complication linked to thyrotoxicosis. Here, we present a rare case of thyrotoxicosis induced cardiomyopathy in a 30-year-old male, where dilated cardiomyopathy manifested as the initial sign of thyrotoxicosis. The patient was treated with antithyroid drugs, diuretics and beta blockers. General surgery opinion obtained and planned to do thyroidectomy after euthyroid status. Patient was followed up and after 6 weeks was symptomatically better and was found to be euthyroid and repeat 2D ECHO showed an improvement in systolic function with EF of 55% and the patient was planned for thyroidectomy. In the management of thyrotoxicosis induced cardiomyopathy, pharmacological interventions involve the use of specific thyroid therapies such as thionamides (methimazole, carbimazole, propylthiouracil) and beta-blockers, coupled with heart failure management.

Given that the extracellular matrix polymer hyaluronan (HA) has been implicated in longevity, we asked whether 4-methylumbelliferone (4-MU), an inhibitor of HA synthesis, impacts lifespan in mice. We designed a prospective study of long-term administration of 4-MU with conventional C57BL/6J mice. We find that 4-MU extends median survival from 122 weeks (control) to 154 weeks (4-MU), an increase of 32 weeks (p < 0.0001 by Log-rank Mantel Cox test). The maximum lifespan of 4-MU treated mice increased from 159 to 194 weeks. In tandem with these effects, 4-MU enhances insulin sensitivity, a metabolic parameter known to regulate lifespan, as measured by insulin tolerance testing (ITT) as well as frequent sampling intra venous glucose tolerance tests (FSIVGTTs). We further observed that 4-MU treated mice weigh less while consuming the same amount of food, indicating that 4-MU treatment alters energy expenditure. However, we do not observe changes in tissue HA content in this model. We conclude that 4-MU promotes insulin sensitivity and longevity but that the underlying mechanism, and the contribution of HA is unclear. 4-MU, already approved in various countries for hepatobiliary conditions, is currently under investigation and clinical development as a therapy for several chronic inflammatory conditions. These data suggest that the beneficial effects of 4-MU on tissue metabolism may include effects on longevity.

Sulfur doped graphitic carbon nitride nanosheets were synthesized via polycondensation reaction of urea-thiourea mixture. Structure and morphology were characterized by XRD (X-ray diffraction), SEM (scanning electron microscope), and XPS (X-ray Photoelectron Spectroscopy). DRS (diffuse reflectance spectroscopy), PL (Photoluminescence spectroscopy) and time-resolved fluorescence decay spectra were used to study the optical characteristics. The photocatalytic dye degradation of Rhodamine B (RhB) in the presence of as-synthesized catalysts was investigated with the help of a UV–visible spectrophotometer. The photocatalytic activity of carbon nitride prepared from urea-thiourea mixture is almost three times higher than that of the pure sample. The detection of Fe3+ was also investigated by using the fluorescence sensing method. The as-synthesized samples hold greater selectivity and sensitivity for fluorescence sensing of Fe3+within a range of 0–3 µM. This range is comparable to the performance of other Fe3+ fluorescent probes previously reported.

Given that the extracellular matrix polymer hyaluronan (HA) has been implicated in longevity, we asked whether 4-methylumbelliferone (4-MU), an inhibitor of HA synthesis, impacts lifespan in mice. We designed a prospective study of long-term administration of 4-MU with conventional C57BL/6J mice. We find that 4-MU extends median survival from 122 weeks (control) to 154 weeks (4-MU), an increase of 32 weeks (p < 0.0001 by Log-rank Mantel Cox test). The maximum lifespan of 4-MU treated mice increased from 159 to 194 weeks. In tandem with these effects, 4-MU enhances insulin sensitivity, a metabolic parameter known to regulate lifespan, as measured by insulin tolerance testing (ITT) as well as frequent sampling intra venous glucose tolerance tests (FSIVGTTs). We further observed that 4-MU treated mice weigh less while consuming the same amount of food, indicating that 4-MU treatment alters energy expenditure. However, we do not observe changes in tissue HA content in this model. We conclude that 4-MU promotes insulin sensitivity and longevity but that the underlying mechanism, and the contribution of HA is unclear. 4-MU, already approved in various countries for hepatobiliary conditions, is currently under investigation and clinical development as a therapy for several chronic inflammatory conditions. These data suggest that the beneficial effects of 4-MU on tissue metabolism may include effects on longevity. [ABSTRACT FROM AUTHOR]

The present study aims to propose an integrated watershed development plan for the Wainganga basin situated in Maharashtra, India. Also, the study involves evaluating the performance and applicability of SWAT (Soil and Water Assessment Tool) as a runoff model along with the trend analysis of rainfall for the above mentioned study area. The decadal land-use/land-cover (LULC) variation from 1985 to 2005 has been studied using data procured from Goddard Earth Sciences Data and Information Services Center (GES-DISC) and the groundwater table level of the study area was monitored using dug/bore well data collected from the Central Ground Water Board (CGWB). Rainfall trend analysis for a period of 101 years using historic rainfall data procured from the India Meteorological Department (IMD) has been analyzed to foresee the future scenario. It was observed that the rainfall-runoff relationship of the area is getting affected by the LULC variation and is thereby affecting the groundwater regime. There is a significant deterioration in the forest cover and water bodies which is alarming. The study devises the importance of an immediate master plan to be implemented in the basin to avoid any future crisis. Also, the study emphasizes the advancement of remote sensing in the use of hydrologic models like SWAT more realistically. HIGHLIGHTS The present study incorporates an integrated approach for watershed planning.; Rainfall runoff relationships were identified.; Land use-land cover anomalies and rainfall trend characteristics were analyzed.;