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The article considers the role of the human factor among the causes of the emergence of dangerous situations. The analysis of statistical data on the number of industrial accidents, as well as the accidents with fatal consequences in the period from 2005 to 2017 is conducted. It is established that the level of total injuries is decreasing, but the costs connected with the elimination of the consequences of accidents are increasing. The level of traumatism with fatal consequences has almost not changed in recent years. Our studies have shown that a human factor can be the cause of workplace accidents, but it is also the key to finding out how other aspects of the labour process are influenced by workers' actions. The aim of the work is to evaluate the influence of the human factor during the organization of the labor process, in terms of its importance in the prevention of occupational injuries and the creation of safe working conditions. On the base of well-known models on emergency situation rising, we propose the approaches on which the methods of practical implementation of preventive measures are based. Employees must realize that an important element in increasing the level of safety of production is the formation of safety culture, a positive attitude to safety issues, respect, and active interaction in preventing the implementation of risks in the workplace. Only joint efforts of employers, employees, and public authorities can solve the issue of labor safety at every workplace.