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1. Contents, Vol. 20, 1978

Author

U. Wolf, S. Scappaticci, J. Couturier, M. Freund, A.C. Adams, J. Olert, K. Benirschke, H.G. Schwarzacher, T.C. Hsu, O.A. Ryder, I.H. Pawlowitzki, P.M. Ellis, B. Dutrillaux, J.M. Clarkson, S. Ciccarese, M. Fraccaro, N. Takagi, O.J. Miller, D.A. Miller, K.W. Jones, E. Rudak, J. Lejeune, N. Canning, A.-V. Mikelsaar, E. Viegas-Pequignot, P.A. Jacobs, E.M. Eicher, G. Fanconi, E.J.T. Winsor, R. Tantravahi, D.R. Thompson, J.T. Martsolf, M.M. Cohen, A. Levan, W. Schnedl, N. Mandahl, M.A. Ferguson-Smith, A. Stahl, M. Devictor, A. Boué, N. Wake, C.V. Beechey, W. Schmid, G. Levan, N. Gregson, M. Hartung, A. Bradley, C. Richler, R. Goitein, L. Tiepolo, M. Ray, S. Mould, J. Wahrman, J. German, J. Pearson, M. Schmid, K.E. Buckton, J. Ryde, O. Zuffardi, A. Markvong, E. Günther, B.M. Cattanach, M.F. Croquette, N. Gadoth, S.A. Latt, M. Mayer, V.G. Dev, N.C. Epel, J.T. Marshall, Y. Nagai, J. Coget, W. Engel, M. Sasaki, H.J. Evans, J.L.P. Hunter, A.G. Searle, J. Boué, C.K. Eun, Y. Rosen, J.A. Evans, J. Dagan, D.A. Hungerford, S.M. Galloway, E.P. Evans, A.G.W. Hunter, A. Aurias, M. Mikkelsen, A. Rosenmann, S. Ohno, A. Hansson, M.D. Burtenshaw, H.P. Klinger, M.T. Zenzes, J.L. Hamerton, J. Kinross, E. Pacifico, A. de la Chapelle, M. Seabright, J.M. Luciani, C.G. Palmer, A. Tal, and P. Grönman

Subjects
Botany, Genetics, Biology, Molecular Biology, Genetics (clinical)
Published
1978

2. Characterization of sister chromatid exchange induction by 8-methoxypsoralen plus near UV light

Author

K.S. Loveday and S.A. Latt

Subjects
Ultraviolet Rays, DNA damage, Sister chromatid exchange, Chromatids, In Vitro Techniques, Biology, chemistry.chemical_compound, Cricetulus, Cricetinae, Genetics, medicine, Animals, Sister chromatids, Molecular Biology, Cells, Cultured, Genetics (clinical), DNA synthesis, Methoxsalen, Chinese hamster ovary cell, Ovary, DNA, Molecular biology, chemistry, Female, Chromatid, medicine.drug
Abstract

The combination of 8-methoxypsoralen and near UV light is highly effective in inducing sister chromatid exchanges (SCEs) in Chinese hamster ovary cells. Appreciable increases in SCEs can be effected by treatments compatible with cell survival, and effects of a single dose of alkylation persist over multiple generations. Both the frequency and location of SCEs induced at different times within the DNA synthesis period varies in a manner indicating that exchange induction is restricted to regions which replicated during or after DNA damage.

Published
1978

3. DNA-based detection of chromosome deletion and amplification: diagnostic and mechanistic significance

Author

S.A. Latt, M. Lalande, T. Donlon, A. Wyman, E. Rose, Y. Shiloh, B. Korf, U. Muller, K. Sakai, N. Kanda, J. Kang, H. Stroh, P. Harris, G. Bruns, R. Wharton, and L. Kaplan

Subjects
Genetics, Chromosome Aberrations, Male, Chromosomes, Human, Pair 15, Chromosomes, Human, Pair 13, Eye Neoplasms, DNA, Recombinant, Gene Amplification, Retinoblastoma, Chromosome, Chromosome Mapping, Biology, Gonadal Dysgenesis, Biochemistry, Cell Line, chemistry.chemical_compound, Neuroblastoma, chemistry, Y Chromosome, Humans, Chromosome Deletion, Molecular Biology, Prader-Willi Syndrome, DNA
Published
1986

4. Multiple cytogenetic methods used to identify a new structural rearrangement of the human X chromosome

Author

P. Grönman, A. de la Chapelle, and S.A. Latt

Subjects
Adult, congenital, hereditary, and neonatal diseases and abnormalities, endocrine system, X Chromosome, Mitosis, Turner Syndrome, Abnormal cell, Biology, Cell Line, Genetics, Humans, Lymphocytes, Primary amenorrhea, Molecular Biology, Amenorrhea, Genetics (clinical), X chromosome, Sex Chromosome Aberrations, Sex Chromosomes, Karyotype, Fibroblasts, Molecular biology, Genetic Techniques, Blood Group Antigens, Female, Pure gonadal dysgenesis
Abstract

A woman with primary amenorrhea and pure gonadal dysgenesis had two cytogenetically abnormal cell lines. The karyotype was 45,X in 56--95% of mitosis from lymphocytes and skin fibroblasts. In the remaining 5--44% of the cells there was, in addition to a normal X, a structurally abnormal X chromosome interpretable as pter leads to q21::q11 leads to pter or pter leads to q21::q13 leads to pter. The abnormal X chromosome was heterocyclic and had a normal centromere plus an extra C band in the long arm. Detailed interpretation of the structural rearrangements of this chromosome required the use of both Q-, G-, and C-banding and the BrdU-Hoechst 33258 technique.

Published
1978

5. Cobalt Proteases: Implications of Absorption and Circular Dichroism Spectra for Catalysis

Author

B.L. Vallee and S.A. Latt

Subjects
inorganic chemicals, chemistry.chemical_classification, Circular dichroism, biology, Stereochemistry, Active site, chemistry.chemical_element, Carboxypeptidase, Catalysis, Metal, Crystallography, Enzyme, chemistry, visual_art, Carbonic anhydrase, biology.protein, visual_art.visual_art_medium, Cobalt
Abstract

Publisher Summary This chapter discusses implications of absorption and circular dichroism (CD) spectra for analysis. Preliminary spectra of cobalt neutral protease are similar to those of cobalt carboxypeptidase, except that the signs of the CD bands are opposite. The similarity of spectral patterns among these cobalt proteases, and those of cobalt alkaline phosphatase and the alkaline spectrum of cobalt carbonic anhydrase , could have functional implications for the metal within each group; cobalt spectra might be a characteristic feature of the catalytic process in different metalloenzymes. Thus, like the chemical reactives of enzymes, the physical properties of appropriate metalloenzymes may constitute an apparent link between their chemical and functional properties. The essentiality of metal atoms to the function of metalloenzymes has clearly been shown by the loss of catalytic activity consequent to their removal. Metal atoms may restore activity on combining with specific ligands of such inactive apoenzymes and can, thus, be viewed as active site reagents.

Published
1970

6. Subject Index Vol. 20, 1978

Author

A. Bradley, M. Mikkelsen, A. Rosenmann, J. Wahrman, E. Rudak, E.J.T. Winsor, O.J. Miller, P.M. Ellis, C.K. Eun, N. Takagi, J. Dagan, O.A. Ryder, H.G. Schwarzacher, A. Hansson, A. Tal, M.D. Burtenshaw, I.H. Pawlowitzki, P. Grönman, M.T. Zenzes, B. Dutrillaux, K.W. Jones, N. Mandahl, J.M. Clarkson, E. Viegas-Pequignot, M. Ray, J.L. Hamerton, M. Fraccaro, J. Coget, J. German, A. Stahl, M. Devictor, J.T. Martsolf, J. Lejeune, M. Sasaki, N. Gregson, W. Schmid, G. Levan, D.R. Thompson, M.A. Ferguson-Smith, H.J. Evans, M. Seabright, S.A. Latt, M.M. Cohen, A. Levan, W. Engel, C.V. Beechey, J.M. Luciani, L. Tiepolo, N. Wake, N. Canning, A. Boué, J.A. Evans, R. Goitein, G. Fanconi, S. Ciccarese, J.T. Marshall, J. Ryde, C.G. Palmer, Y. Nagai, A.G.W. Hunter, M.F. Croquette, J. Couturier, M. Freund, M. Mayer, D.A. Miller, M. Schmid, N.C. Epel, S. Mould, K. Benirschke, K.E. Buckton, A. Markvong, E.P. Evans, N. Gadoth, E.M. Eicher, T.C. Hsu, J. Kinross, A. de la Chapelle, A. Aurias, J. Boué, P.A. Jacobs, Y. Rosen, D.A. Hungerford, J.L.P. Hunter, A.G. Searle, S.M. Galloway, J. Pearson, E. Pacifico, A.C. Adams, S. Ohno, H.P. Klinger, U. Wolf, S. Scappaticci, C. Richler, J. Olert, O. Zuffardi, E. Günther, R. Tantravahi, W. Schnedl, V.G. Dev, M. Hartung, B.M. Cattanach, and A.-V. Mikelsaar

Subjects
Index (economics), Statistics, Genetics, Subject (documents), Biology, Molecular Biology, Genetics (clinical)
Published
1978

7. Subject Index Vol. 33, 1982

Author

A.G. Searle, E. Sahar, G. Decat, J.W.I.M. Simons, D. Scott, Y. Ohnuki, B. Lambert, A. Brøgger, M. Meijers, S.A. Latt, L.W. Jones, T.N. Kaiser, S.E. Bates, J. Mäki-Paakkanen, L. Juergens, R.C. Woodruff, M. Sten, W.M. Generoso, A. Léonard, A. Lojewski, S. Wolff, J.N. Thompson, H. Vainio, R.R. Schreck, K. Mikamo, S. Brefach, S.A.F. Farook, M.E. Kaighn, W. McKenzie, N.P. Bochkov, L.H. Thompson, C. Dougherty, M. Lalande, S. Kondo, M.E. Gaulden, E.B. Hook, K.N. Yakovenko, A.A. van Zeeland, H.J. Evans, K. Gustashaw, J.F. Lechner, R.B. Painter, L. Fabry, M. Powers, I.-D. Adler, A.T. Natarajan, M. Sorsa, N.I. Voskoboiynik, D.J.G. Parkes, M. Sasaki, H.P. Klinger, A.V. Carrano, G. Deknudt, C.V. Beechey, A. Bredberg, B.K. Vig, R.J. Preston, T.M. Schroeder, W.W. Nichols, and M. Cornforth

Subjects
Index (economics), Statistics, Genetics, Subject (documents), Biology, Molecular Biology, Genetics (clinical)
Published
1982

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