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2. Identification of New Regulators of the Oocyte-to-Embryo Transition in Drosophila

Author

Emir E. Avilés-Pagán, Albert S. W. Kang, and Terry L. Orr-Weaver

Subjects
mitosis, embryogenesis, oogenesis, f-box protein, glucose transporter, Genetics, QH426-470
Abstract

At the oocyte-to-embryo transition the highly differentiated oocyte arrested in meiosis becomes a totipotent embryo capable of embryogenesis. Oocyte maturation (release of the prophase I primary arrest) and egg activation (release from the secondary meiotic arrest and the trigger for the oocyte-to-embryo transition) serve as prerequisites for this transition, both events being controlled posttranscriptionally. Recently, we obtained a comprehensive list of proteins whose levels are developmentally regulated during these events via a high-throughput quantitative proteomic analysis of Drosophila melanogaster oocyte maturation and egg activation. We conducted a targeted screen for potential novel regulators of the oocyte-to-embryo transition, selecting 53 candidates from these proteins. We reduced the function of each candidate gene using transposable element insertion alleles and RNAi, and screened for defects in oocyte maturation or early embryogenesis. Deletion of the aquaporin gene CG7777 did not affect female fertility. However, we identified CG5003 and nebu (CG10960) as new regulators of the transition from oocyte to embryo. Mutations in CG5003, which encodes an F-box protein associated with SCF-proteasome degradation function, cause a decrease in female fertility and early embryonic arrest. Mutations in nebu, encoding a putative glucose transporter, result in defects during the early embryonic divisions, as well as a developmental delay and arrest. nebu mutants also exhibit a defect in glycogen accumulation during late oogenesis. Our findings highlight potential previously unknown roles for the ubiquitin protein degradation pathway and sugar transport across membranes during this time, and paint a broader picture of the underlying requirements of the oocyte-to-embryo transition.

Published
2020
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7. A cluster analysis of patients with axial spondyloarthritis using tumour necrosis factor alpha inhibitors based on clinical characteristics

Author

Hoon-Suk Cha, Hong-Hee Won, Eun-Mi Koh, Jaejoon Lee, S W Kang, Yeonghee Eun, Seulkee Lee, and Hyung-Jin Kim

Subjects
medicine.medical_specialty, medicine.medical_treatment, TNF, Disease, Diseases of the musculoskeletal system, Targeted therapy, Cluster analysis, Drug survival, Internal medicine, Psoriasis, Spondyloarthritis, Medicine, Humans, Axial spondyloarthritis, business.industry, Enthesitis, medicine.disease, Rheumatology, Treatment Outcome, RC925-935, Orthopedic surgery, Tumor Necrosis Factor Inhibitors, medicine.symptom, business, Uveitis, Axial Spondyloarthritis, Research Article
Abstract

BackgroundThis study aimed to classify the distinct group of patients with axial spondyloarthritis (SpA) on tumour necrosis factor alpha inhibitors (TNFi) according to the baseline characteristics using a clustering algorithm.MethodsThe clinical characteristics and demographic data of patients with axial SpA included in the Korean College of Rheumatology Biologics and Targeted Therapy registry were investigated. The patterns of disease manifestations were examined using divisive hierarchical cluster analysis. After clustering, we compared the clinical characteristics of patients and the drug survival of TNFi between the classified groups.ResultsA total of 1042 patients were analysed. The cluster analysis classified patients into two groups: axial group predominantly showing isolated axial manifestations (n= 828) and extra-axial group more frequently showing extra-axial symptoms (n= 214). Almost all extra-axial symptoms (peripheral arthritis, enthesitis, uveitis, and psoriasis) were more frequently observed in the extra-axial group than in the axial group. Moreover, patients in the extra-axial group had shorter disease duration, later disease onset, and higher disease activity than those in the axial group. The disease activity was comparable between the two groups after 1 year of treatment with TNFi. Interestingly, the extra-axial group had a lower drug survival with TNFi than the axial group (p= 0.001).ConclusionsCluster analysis of patients with axial SpA using TNFi classified two distinct clinical phenotypes. These clusters had different TNFi drug survival, clinical characteristics, and disease activity.

Published
2021

10. Besca, a single-cell transcriptomics analysis toolkit to accelerate translational research

Author

Martin Ebeling, Luis Wyss, Alice Julien-Laferriere, Petra C. Schwalie, Albert S. W. Kang, Klas Hatje, Eric Ulrich, Laura Badi, Sophia Clara Mädler, Anthony Sonrel, Miroslav Phan, Jitao David Zhang, Roland Schmucki, and Tony Kam-Thong

Subjects
AcademicSubjects/SCI01140, AcademicSubjects/SCI01060, Interoperability, genetic processes, AcademicSubjects/SCI00030, Translational research, computer.software_genre, AcademicSubjects/SCI01180, Annotation, Software, Structural Biology, Genetics, natural sciences, Cluster analysis, Molecular Biology, Reusability, Interpretability, business.industry, Applied Mathematics, Computer Science Applications, Methart, Workflow, Data mining, AcademicSubjects/SCI00980, business, computer
Abstract

Single-cell RNA sequencing (scRNA-seq) revolutionized our understanding of disease biology. The promise it presents to also transform translational research requires highly standardized and robust software workflows. Here, we present the toolkit Besca, which streamlines scRNA-seq analyses and their use to deconvolute bulk RNA-seq data according to current best practices. Beyond a standard workflow covering quality control, filtering, and clustering, two complementary Besca modules, utilizing hierarchical cell signatures and supervised machine learning, automate cell annotation and provide harmonized nomenclatures. Subsequently, the gene expression profiles can be employed to estimate cell type proportions in bulk transcriptomics data. Using multiple, diverse scRNA-seq datasets, some stemming from highly heterogeneous tumor tissue, we show how Besca aids acceleration, interoperability, reusability and interpretability of scRNA-seq data analyses, meeting crucial demands in translational research and beyond., NAR Genomics and Bioinformatics, 3 (4), ISSN:2631-9268

Published
2021

13. Hardness prediction of a cold rolled Nimonic 80A exhaust valve spindle

Author

S. W. Kang, J. H. Yoo, S. J. Heo, and J. H. Kang

Subjects
Materials science, Mechanics of Materials, Exhaust valve, Stress–strain curve, General Materials Science, Nimonic, Composite material, Industrial and Manufacturing Engineering, Finite element method
Abstract

Purpose: of this paper is to predict the hardness of cold rolled exhausts valve spindle fabricated of Nimonic 80A via axisymmetric finite element analysis, compression testing, and hardness inspection. Design/methodology/approach: The stress-strain relationship of Nimonic 80A was obtained via compression testing with deformation ratios of 10%, 20%, and 30%. Hardness changes caused by the strain hardening effect were measured in cut specimens in both the axial and circumferential directions following compression testing. The effective strain at the measurement position was calculated via finite element analysis. The regression equation for hardness changes caused by work hardening was derived from analysed strain and inspected hardness. The cold-rolling deformation of an exhaust valve spindle was analysed using axisymmetric finite element analysis. Findings: The stress-strain relationship calculated from compression testing was well expressed using the Holloman equation and the strain-hardness relationship by strain hardening was successfully regressed using the shifted power law model for Nimonic 80A, Nickel-Chromium based super alloy. Research limitations/implications: This research focused hardness prediction of spindle after ring rolling operation for generating beneficial compressive surface residual stresses for enhancing fatigue life. Further research to quantify compressive residual stress after rolling shall be followed to increase fatigue life. Practical implications: The cold rolling process is a typical incremental forming method and should be analysed under three-dimensional conditions. However, it takes lots of time to solve incremental forming analysis. To predict hardness distribution after rolling in the manufacturing field, FE analysis was performed under two-dimensional axisymmetric conditions based on the assumption of no friction generated by the rolling tool. The deformed shapes and hardness distribution from the inspection quality standard and two-dimensional FE analysis showed very similar results. Simplified finite element analysis method for ring rolling process for local area could be very effective method in the industrial field. Originality/value: The stress-strain relationship and the hardness and strain relationship were derived by compression test and hardness measurement for compressed specimen for Nimonic 80A, Nickel-Chromium based super alloy. And simplified finite element analysis method was suggested to predict deformed shape and hardness distribution of locally cold rolled region and achieved similar result between FE analysis result and Quality standard. Suggested method would be very effective method to engine spindle manufacture to predict hardness of different size of product.

Published
2019

14. Application of Nondimensional Dynamic Influence Function Method for Eigenmode Analysis of Two-Dimensional Acoustic Cavities

Author

S. W. Kang and S. N. Atluri

Subjects
Mechanical engineering and machinery, TJ1-1570
Abstract

This paper establishes an improved NDIF method for the eigenvalue extraction of two-dimensional acoustic cavities with arbitrary shapes. The NDIF method, which was introduced by the authors in 1999, gives highly accurate eigenvalues despite employing a small number of nodes. However, it needs the inefficient procedure of calculating the singularity of a system matrix in the frequency range of interest for extracting eigenvalues and mode shapes. The paper proposes a practical approach for overcoming the inefficient procedure by making the final system matrix equation of the NDIF method into a form of algebraic eigenvalue problem. The solution quality of the proposed method is investigated by obtaining the eigenvalues and mode shapes of a circular, a rectangular, and an arbitrarily shaped cavity.

Published
2014
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16. Multiple rereads of single proteins at single-amino acid resolution using nanopores

Author

Cees Dekker, Albert S. W. Kang, Henry Brinkerhoff, Jingqian Liu, and Aleksei Aksimentiev

Subjects
Proteomics, chemistry.chemical_classification, Cell signaling, Multidisciplinary, Sequence analysis, Resolution (electron density), DNA Helicases, Peptide, Computational biology, Molecular Dynamics Simulation, Nanopores, Nanopore, Amino Acid Substitution, chemistry, Sequence Analysis, Protein, Single amino acid, Amino Acids, Peptides
Abstract

Reading amino acids by nanopore Nanopore technology enables sensing of minute chemical changes at the single-molecule level by detecting differences in an ion current as molecules are drawn through a membrane-embedded pore. The sensitivity is sufficient to discriminate between nucleotide bases in nanopore sequencing, and other applications of this technology are promising. Brinkerhoff et al . developed a nanopore-based, single-molecule approach in which a protein was sequentially scanned in single-amino-acid steps through the narrow construction of a nanopore, and ion currents were monitored to resolve differences in the amino acid sequence along the peptide backbone (see the Perspective by Bošković and Keyser). The peptide reader was capable of reliably detecting single-amino-acid substitutions within individual peptides. An individual protein could be re-read many times, yielding very high read accuracy in variant identification. These proof-of-concept nanopore experiments constitute a promising basis for the development of a single-molecule protein sequencer. —DJ

Published
2021

17. AB0037 APE1 REGULATES THE MIGRATION OF FIBROBLAST-LIKE SYNOVIOCYTES FROM PATIENTS WITH RHEUMATOID ARTHRITIS

Author

H. R. Lee, J. Kim, S. J. Yoo, J. A. Park, H. K. Joo, Y. R. Lee, S. Kim, B. H. Jeon, and S. W. Kang

Subjects
Rheumatology, Immunology, Immunology and Allergy, General Biochemistry, Genetics and Molecular Biology
Abstract

BackgroundThe level of apurinic/apyrimidinic endonuclease 1 (APE1) is elevated in synovial fluids from patients with rheumatoid arthritis (RA). However, the role of APE1 in RA pathogenesis remains unclear.ObjectivesTo explore whether APE1 affects cell migration through reactive oxygen species (ROS) level, fibroblast-like synoviocytes (FLS) from patients with RA were stimulated with human recombinant APE1.MethodsSynovial tissues were obtained from RA patients who were undergoing synovectomy or joint replacement. The isolated cells were cultured in Dulbecco’s modified Eagle’s medium (DMEM) supplemented with 10% fetal bovine serum and maintained in a 5% CO2 incubator at 37 °C. FLS were used for experiments after three to six passages. Cells were stimulated with or without recombinant interleukin 17 (IL-17; 10 ng/ml), tumor necrosis factor alpha (TNF-α; 10 ng/ml), and long-lasting recombinant human APE1 (MR201; 1, 10, 100 ng/ml) for 24 h. ROS levels were analyzed using MitoSOX dye. Cell migratory ability was examined using wound migration assay.ResultsRA FLS treated with APE1 showed slightly decreased level of mitochondrial specific ROS. To induce pro-inflammatory conditions, RA FLS were incubated with IL-17 and TNF-α. These cytokines are highly detected in RA synovium and directly stimulate FLS activation. Stimulation with IL-17 and TNF-α upregulated ROS by 30% compared to control. Cytokines-induced increase of ROS was inhibited by 22% in APE1 treatment. When FLS cultures were approximately 90% confluent, FLS monolayers were wounded with pipette tips and treated with IL-17/TNF-α and APE1 for 24 h. Cell migration was increased after treatment with IL-17/TNF-α. Cytokines-induced cell migration was remarkably attenuated by APE1 treatment.ConclusionRecombinant APE1 markedly inhibited mitochondrial specific ROS production and IL-17/TNF-α-induced cell migration in RA FLS.References[1]Bartok B, Firestein GS. Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis. Immunol Rev. 2010;233(1):233–55.[2]Mateen S, Moin S, Khan AQ, Zafar A, Fatima N. Increased reactive oxygen species formation and oxidative stress in rheumatoid arthritis. PLoS One. 2016;11(4):e0152925.[3]Lefevre S, Knedla A, Tennie C, Kampmann A, Wunrau C, Dinser R, Korb A, Schnaker EM, Tarner IH, Robbins PD, et al. Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nat Med. 2009;15(12):1414–20.AcknowledgementsThis research was supported by Chungnam National University Hospital Research Fund, 2021.Disclosure of InterestsNone declared

Published
2022

18. Ready-to-use nanopore platform for the detection of any DNA/RNA oligo at attomole range using an Osmium tagged complementary probe

Author

William E. Jack, Albert S. W. Kang, Anastassia Kanavarioti, and Janette G. Bernasconi

Subjects
0301 basic medicine, lcsh:Medicine, chemistry.chemical_element, Article, 03 medical and health sciences, chemistry.chemical_compound, Nanopores, 0302 clinical medicine, Nanotechnology, Osmium, lcsh:Science, Multidisciplinary, Oligonucleotide, Chemistry, Diagnostic Tests, Routine, lcsh:R, RNA, Bioanalytical chemistry, Diagnostic markers, DNA, Sequence Analysis, DNA, Nanopore, MicroRNAs, 030104 developmental biology, Osmium tetroxide, 030220 oncology & carcinogenesis, Minion, Biophysics, lcsh:Q, Nanopore sequencing
Abstract

Nanopores can serve as single molecule sensors. We exploited the MinION, a portable nanopore device from Oxford Nanopore Technologies (ONT), and repurposed it to detect any DNA/RNA oligo (target) in a complex mixture by conducting voltage-driven ion-channel measurements. The detection and quantitation of the target is enabled by the use of a unique complementary probe. Using a validated labeling technology, probes are tagged with a bulky Osmium tag (Osmium tetroxide 2,2’-bipyridine), in a way that preserves strong hybridization between probe and target. Intact oligos traverse the MinION’s nanopore relatively quickly compared to the device’s acquisition rate, and exhibit count of events comparable to the baseline. Counts are reported by a publicly available software,OsBp_detect. Due to the presence of the bulky Osmium tag, probes traverse more slowly, produce multiple counts over the baseline, and are even detected at single digit attomole (amole) range. In the presence of the target the probe is “silenced”. Silencing is attributed to a 1:1 double stranded (ds) complex that doesn’t fit and can’t traverse this nanopore. This ready-to-use platform can be tailored as a diagnostic test to meet the requirements for point-of-care cell-free tumor DNA (ctDNA) and microRNA (miRNA) detection and quantitation in body fluids.

Published
2020

19. Besca, a single-cell transcriptomics analysis toolkit to accelerate translational research

Author

Martin Ebeling, Roland Schmucki, Tony Kam-Thong, Miroslav Phan, Alice Julien-Laferriere, Klas Hatje, Laura Badi, Jitao David Zhang, Eric Ulrich, Luis Wyss, Petra C. Schwalie, Sophia Clara Mädler, and Albert S. W. Kang

Subjects
Annotation, Workflow, Single cell transcriptomics, Interoperability, Translational research, Data mining, Cluster analysis, computer.software_genre, computer, Reusability, Interpretability
Abstract

Single-cell RNA sequencing (scRNA-seq) revolutionised our understanding of disease biology and presented the promise of transforming translational research. We developed Besca, a toolkit that streamlines scRNA-seq analyses according to current best practices. A standard workflow covers quality control, filtering, and clustering. Two complementary Besca modules, utilizing hierarchical cell signatures or supervised machine learning, automate cell annotation and provide harmonised nomenclatures across studies. Subsequently, Besca enables estimation of cell type proportions in bulk transcriptomics studies. Using multiple heterogeneous scRNA-seq datasets we show how Besca aids acceleration, interoperability, reusability, and interpretability of scRNA-seq data analysis, crucial aspects in translational research and beyond.

Published
2020

20. Interpretation of polysomnography in myotonic muscular dystrophy type 1

Author

S.-W. Kang, Minah Suh, D.H. Kim, W.A. Choi, and E.Y. Kim

Subjects
medicine.medical_specialty, medicine.diagnostic_test, Myotonic muscular dystrophy, business.industry, Internal medicine, medicine, Cardiology, General Medicine, Polysomnography, business, Interpretation (model theory)
Published
2019

21. Matrix Metalloproteinase Gene Polymorphisms and New-Onset Diabetes After Kidney Transplantation in Korean Renal Transplant Subjects

Author

S.-K. Kim, S. Ong, J.-Y. Moon, S.-K. Seo, J.-H. Chung, Y.-C. Yoon, S.-W. Kang, Y.-H. Kim, T.-W. Lee, S.-H. Lee, Chun-Gyoo Ihm, K.-H. Jeong, and T.-H. Kim

Subjects
Adult, Genetic Markers, Male, medicine.medical_specialty, medicine.medical_treatment, 030209 endocrinology & metabolism, Single-nucleotide polymorphism, 030204 cardiovascular system & hematology, Biology, Polymorphism, Single Nucleotide, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Asian People, Gene Frequency, Risk Factors, Diabetes mellitus, Internal medicine, Republic of Korea, medicine, Humans, Kidney transplantation, Transplantation, Insulin, Type 2 Diabetes Mellitus, Middle Aged, medicine.disease, Kidney Transplantation, Transplant Recipients, Tacrolimus, Endocrinology, Diabetes Mellitus, Type 2, Matrix Metalloproteinase 2, Female, Surgery
Abstract

Background New-onset diabetes after transplantation (NODAT) is a serious metabolic complication that may follow renal transplantation. Matrix metalloproteinases (MMPs) contribute to insulin insufficiency and beta-cell dysfunction in a rat model. The MMP-2 concentrations were lower in patients with type 2 diabetes mellitus, and the plasma MMPs levels were related to diabetes. Similar to the pathogenesis of type 2 diabetes mellitus, insulin resistance and insulin secretion dysfunction occur in patients with the development of NODAT. Therefore, we examined the association between NODAT and 11 single-nucleotide polymorphisms (SNPs) located within the 3 genes of MMPs that might be related to NODAT. Methods A total of 309 renal transplant recipients without a history of diabetes were included in this study. DNA was extracted from the blood samples of recipients, and we analyzed the association between the development of NODAT and a panel of 11 SNPs within 3 MMP genes (MMP-1, MMP-2, and MMP-3). Results In terms of allele frequencies, rs243849*C (MMP-2) was significantly higher in patients with NODAT. Two of the 11 (18.1%) SNPs were significantly associated with NODAT development after adjusting for age, sex, and tacrolimus usage: MMP-2 (rs1132896) and MMP-2 (rs243849). In the multiple logistic regression analysis, these 2 SNPs were significantly associated with the development of NODAT in the codominant and recessive or codominant and dominant models. Conclusions MMP-2 gene rs1132896 and rs243849 polymorphisms may serve as genetic markers for the development of NODAT. The exact molecular mechanisms still must be clarified.

Published
2016

22. In-situ Hybridization for the Detection of Sacbrood Virus in Infected Larvae of the Honey Bee (Apis cerana)

Author

H.S. Kang, M.-S. Yoo, B.-S. Yoon, H.-Y. Lim, Jiwoon Jeong, C. Chae, Kyuhyung Choi, Y.-H. Kim, Changhoon Park, S.-W. Kang, and I. Kang

Subjects
0106 biological sciences, 0301 basic medicine, Picornaviridae, In situ hybridization, Polymerase Chain Reaction, 01 natural sciences, Genome, Pathology and Forensic Medicine, law.invention, 03 medical and health sciences, law, Complementary DNA, Animals, In Situ Hybridization, Apis cerana, Polymerase chain reaction, Larva, Picornaviridae Infections, General Veterinary, biology, fungi, Sacbrood virus, Honey bee, Bees, biology.organism_classification, Virology, 010602 entomology, 030104 developmental biology
Abstract

The aim of this study was to develop and use in-situ hybridization (ISH) for the detection and localization of the sacbrood virus (SBV) in Korean honey bee (Apis cerana) larvae that were infected naturally with SBV. A 258 base pair cDNA probe for SBV was generated by polymerase chain reaction. Cells positive for viral genome typically showed a dark brown reaction in the cytoplasm. SBV was detected consistently in trophocytes and urocytes. The ISH was successfully applied to routinely fixed and processed tissues and thus should prove helpful in the diagnosis and characterization of viral distribution in infected larvae.

Published
2016

26. Influence of image compression on the interpretation of spectral-domain optical coherence tomography in exudative age-related macular degeneration

Author

Y S Chang, S W Kang, Jung-Sung Kim, and J-r Kim

Subjects
Male, medicine.medical_specialty, genetic structures, Image quality, Angiogenesis Inhibitors, Image processing, Antibodies, Monoclonal, Humanized, Optical coherence tomography, Ranibizumab, Ophthalmology, Image Processing, Computer-Assisted, medicine, Humans, Aged, Retrospective Studies, Aged, 80 and over, Observer Variation, medicine.diagnostic_test, business.industry, Subretinal Fluid, computer.file_format, Middle Aged, Macular degeneration, Data Compression, Image Enhancement, medicine.disease, JPEG, eye diseases, Intravitreal Injections, Wet Macular Degeneration, Clinical Study, Female, sense organs, Image file formats, business, computer, Tomography, Optical Coherence, Data compression, Image compression
Abstract

To evaluate the effect of image compression of spectral-domain optical coherence tomography (OCT) images in the examination of eyes with exudative age-related macular degeneration (AMD). Thirty eyes from 30 patients who were diagnosed with exudative AMD were included in this retrospective observational case series. The horizontal OCT scans centered at the center of the fovea were conducted using spectral-domain OCT. The images were exported to Tag Image File Format (TIFF) and 100, 75, 50, 25 and 10% quality of Joint Photographic Experts Group (JPEG) format. OCT images were taken before and after intravitreal ranibizumab injections, and after relapse. The prevalence of subretinal and intraretinal fluids was determined. Differences in choroidal thickness between the TIFF and JPEG images were compared with the intra-observer variability. The prevalence of subretinal and intraretinal fluids was comparable regardless of the degree of compression. However, the chorio–scleral interface was not clearly identified in many images with a high degree of compression. In images with 25 and 10% quality of JPEG, the difference in choroidal thickness between the TIFF images and the respective JPEG images was significantly greater than the intra-observer variability of the TIFF images (P=0.029 and P=0.024, respectively). In OCT images of eyes with AMD, 50% of the quality of the JPEG format would be an optimal degree of compression for efficient data storage and transfer without sacrificing image quality.

Published
2014

28. CLINICAL ACUTE KIDNEY INJURY 2

Author

S. Gonzalez Sanchidrian, C. J. Cebrian Andrada, M. C. Jimenez Herrero, J. L. Deira Lorenzo, P. J. Labrador Gomez, J. P. Marin Alvarez, V. Garcia-Bernalt Funes, S. Gallego Dominguez, I. Castellano Cervino, J. R. Gomez-Martino Arroyo, W. Parapiboon, P. Boonsom, T. Stadler, A. Raddatz, A. Poppleton, W. Hubner, D. Fliser, M. Klingele, J. Rosa, A. Sydor, M. Krzanowski, E. Chowaniec, W. Sulowicz, E. Vidal, C. Mergulhao, H. Pinheiro, L. Sette, G. Amorim, G. Fernandes, L. Valente, F. Ouaddi, I. Tazi, K. Mabrouk, M. Zamd, S. El Khayat, G. Medkouri, M. Benghanem, B. Ramdani, G. Dabo, L. Badaoui, A. Ouled Lahcen, M. Sosqi, L. Marih, A. Chakib, K. Marhoum El Filali, M. J. C. Oliveira, G. Silva Junior, A. M. Sampaio, B. Montenegro, M. P. Alves, G. A. L. Henn, H. A. L. Rocha, G. C. Meneses, A. M. C. Martins, T. R. Sanches, L. C. Andrade, A. C. Seguro, A. B. Liborio, E. F. Daher, M. Haase, B.-P. Robra, J. Hoffmann, B. Isermann, W. Henkel, R. Bellomo, C. Ronco, A. Haase-Fielitz, Y. K. Kee, Y. L. Kim, E. J. Kim, J. T. Park, S. H. Han, T.-H. Yoo, S.-W. Kang, K. H. Choi, H. J. Oh, P. Dharmendra, M. Vinay, M. Mohit, G. Rajesh, A. Dhananjai, B. Pankaj, P. Campos, A. Pires, L. Inchaustegui, S. Avdoshina, S. Villevalde, Z. Kobalava, P. Mukhopadhyay, B. Das, D. Mukherjee, R. Mishra, M. Kar, N. M. Biswas, M. Onuigbo, N. Agbasi, D. Ponce, B. B. Albino, A. L. Balbi, P. Klin, C. Zambrano, L. M. Gutierrez, L. Varela Falcon, F. Zeppa, A. Bilbao, F. Klein, P. Raffaele, K. Y. Chang, H. S. Park, H. W. Kim, B. S. Choi, C. W. Park, C. W. Yang, D. C. Jin, I.-A. Checherita, I. Peride, C. David, D. Radulescu, A. Ciocalteu, A. Niculae, A. Balbi, C. Goes, M. Buffarah, P. Xavier, S. M. Karimi, G. Cserep, D. Gannon, K. Sinnamon, P. Saudan, C. Alves, V. De La Fuente, B. Ponte, S. Carballo, O. Rutschmann, P.-Y. Martin, F. Stucker, A. Saurina, V. Pardo, N. Barba, E. Jovell, M. Pou, V. Esteve, M. Fulquet, V. Duarte, M. Ramirez De Arellano, I. O. Sun, H. J. Yoon, J. G. Kim, K. Y. Lee, K. Tiranathanagul, S. Sallapant, S. Eiam-Ong, S. Treeprasertsuk, I. A. Checherita, B. Geavlete, M. Ando, N. Shingai, T. Morito, K. Ohashi, K. Nitta, D. B. Duarte, L. A. Vanderlei, R. K. A. Bispo, M. E. Pinheiro, H. Si Nga, A. Paes, P. Medeiros, T. M. S. Gentil, L. S. Assis, A. P. Amaral, V. R. C. A. Alvares, K. L. R. S. Scaranello, E. M. D. Soeiro, V. Castanho, I. Castro, S. M. Laranja, S. Barreto, M. Molina, M. Silvisk, B. J. Pereira, A. Izem, D. Amer Mhamed, S. S. El Khayat, C. Donadio, A. Klimenko, M. C. Andreoli, N. K. Souza, A. L. Ammirati, T. N. Matsui, E. L. Naka, F. D. Carneiro, A. C. Ramos, R. K. Lopes, E. S. Dias, M. P. Coelho, R. C. Afonso, B.-H. Ferraz-Neto, M. D. Almeida, M. Durao, M. C. Batista, J. C. Monte, V. G. Pereira, O. P. Santos, B. C. Santos, V. C. Silva, J. G. Raimann, F. B. Nerbass, M. A. Vieira, P. Dabel, A. Richter, J. Callegari, M. Carter, N. W. Levin, J. F. Winchester, P. Kotanko, R. Pecoits-Filho, A. Gjyzari, N. Thereska, M. Barbullushi, A. Koroshi, E. Petrela, S. Mumajesi, J. S. Han, S. Simone, G. Scrascia, E. Montemurno, C. Rotunno, F. Mastro, L. Gesualdo, D. Paparella, G. Pertosa, D. Lopes, C. Santos, C. Cunha, A. M. Gomes, H. Coelho, J. Seabra, A. Qasem, S. Farag, E. Hamed, M. Emara, A. Bihery, H. Pasha, S. Chhaya, G. Mukhopadhyay, C. Das, A. P. F. Vieira, L. L. L. Lima, L. S. Nascimento, A. Zawiasa, M. Ko Odziejska, P. Bia Asiewicz, D. Nowak, and M. Nowicki

Subjects
Transplantation, Pathology, medicine.medical_specialty, Nephrology, business.industry, Acute kidney injury, medicine, medicine.disease, Diffuse alveolar damage, business
Published
2014

29. PERITONEAL DIALYSIS 2

Author

C. A. Vlahu, M. De Graaff, D. G. Struijk, R. T. Krediet, H.-S. Shin, E.-S. Ryu, H.-S. Choi, D.-R. Ryu, K.-B. Choi, D.-H. Kang, E. Sanchez-Alvarez, C. Rodriguez-Suarez, J. A. Galvan-.Hernandez, Y. L. Kim, Y. K. Kee, M. J. Lee, H. J. Oh, J. T. Park, S. H. Han, T.-H. Yoo, S.-W. Kang, F. Zhu, S. R. Abbas, R. Bologa, B. Lanto, P. Kotanko, A. Parikova, W. Smit, M. Rroji ( Molla), S. Seferi, M. Cafka, N. Thereska, C.-C. Huang, I.-K. Wang, Y.-T. Shiao, L. Teixeira, I. Sousa, A. Rodrigues, D. Mendonca, A. Ueda, M. Iwase, T. Usui, A. Hirayama, K. Nagai, C. Saito, K. Yamagata, V. La Milia, G. Pontoriero, F. Locatelli, S. M. Kim, T. Y. Kim, J. E. Lee, D. Teta, M.-P. Guillodo, A. Kolko-Labadens, C. Lasseur, M. Levannier, M. Panaye, D. Fouque, C. HAMADA, K. Hara, S. H. Kang, K. H. Cho, J. W. Park, K. W. Yoon, J. Y. Do, I. Dogan, B. Biro Dr, G. Zakar Dr, Z. Foldine, S. Staudt, A. R. Martins, R. Vizinho, P. Q. Branco, M. A. Gaspar, J. D. Barata, D. Sikorska, P. Klysz, B. Posnik, E. Baum, K. Hoppe, K. Schwermer, M. Wanic-Kossowska, D. Frankiewicz, K. Pawlaczyk, B. Lindholm, A. Oko, M. Busuioc, P. Trolliet, A. Guerraoui, A. Caillette-Beaudoin, P. Hallonet, J.-O. Yang, M. Gursu, D. Topcuoglu, L. K. Koc, L. Yucel, A. Sumnu, E. Cebeci, B. Doner, O. Ozkan, A. Behlul, L. Koc, S. Ozturk, R. Kazancioglu, A. I. I. Casas Parra, M. T. T. Gonzalez, D. A. Sandoval, G. C. Carlota, J. M. M. Grinyo, C.-H. Tseng, C.-T. Chao, C.-J. Yen, C.-K. Chiang, K.-Y. Hung, J.-W. Huang, J. S. Al Wakeel, M. Al Ghonaim, A. Al Suwaida, A. Al Harbi, Z. Makoshi, S. Abdullah, Y. Matsushita, N. Basic-Jukic, D. Coen-Herak, Z. Martinovic, M. Radi -Antoli, P. Kes, T.-J. Wu, J.-S. Chen, S.-H. Lin, J.-C. Shiang, C.-C. Wu, D. Munteanu, M. Gemene, G. Mircescu, S. Opatrna, A. Popperlova, V. Tesar, I. Rychlik, O. Viklicky, K. Jin, B.-S. Park, H. J. Jeong, Y.-W. Kim, S. Hogas, L. Voroneanu, M. Onofriescu, I. Nistor, M. Apetrii, D. Siriopol, M. Cujba, M. Hogas, and A. Covic

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, medicine.medical_treatment, Urology, Medicine, business, Peritoneal dialysis
Published
2014

30. Peritoneal dialysis - A

Author

M. Ito, A. Emami-Naini, N. Keyvandarian, F. Moeinzadeh, M. Mortazavi, S. Taheri, K. Io, T. Nishino, Y. Obata, M. Kitamura, S. Abe, T. Koji, S. Kohno, K. Wakabayashi, C. Hamada, T. Nakano, R. Kanda, H. Io, S. Horikoshi, Y. Tomino, M. R. Korte, N. Braun, S. M. Habib, E. Goffin, A. Summers, L. Heuveling, M. G. H. Betjes, M. Lambie, J. Bankart, D. Johnson, R. Mactier, L. Phillips-Darby, N. Topley, S. Davies, F. X. Liu, R. Leipold, M. Arici, U. Farooqui, K.-h. Cho, J.-y. Do, S.-h. Kang, J.-W. Park, K.-W. Yoon, S.-Y. Jung, C. Sise, P. Rutherford, L. Kovacs, S. Konings, M. Pestana, J. Zimmermann, H. Cramp, D. Stein, K. Bang, J. H. Shin, J. Jeong, J.-H. Kim, N. Matsuo, Y. Maruyama, M. Nakao, Y. Tanno, I. Ohkido, H. Hayakawa, H. Yamamoto, K. Yokoyama, T. Hosoya, F. Iannuzzella, M. Corradini, L. Belloni, A. Stefani, M. Parmeggiani, S. Pasquali, O. Svedberg, P. Stenvinkel, A. R. Qureshi, P. Barany, O. Heimburger, P. Leurs, B. Anderstam, J. Waniewski, S. Antosiewicz, D. Baczynski, M. Galach, Z. Wankowicz, M. Prabhu, S. V. Subhramanyam, K. S. Nayak, J.-C. Hwang, M.-Y. Jiang, Y.-H. Lu, C.-T. Wang, C. Santos, A. Rodriguez-Carmona, M. Perez Fontan, B. Schaefer, S. Macher-Goeppinger, A. Bayazit, P. Sallay, S. Testa, S. Holland-Cunz, U. Querfeld, B. A. Warady, F. Schaefer, C. P. Schmitt, I. Guney, K. Turkmen, R. Yazici, S. Aslan, L. Altintepe, M. Yeksan, I. Kocyigit, M. Sipahioglu, O. Orscelik, A. Unal, A. Celik, S. Abbas, F. Zhu, B. Tokgoz, A. Dogan, O. Oymak, P. Kotanko, N. Levin, M. C. Sanchez-Gonzalez, M. L. Gonzalez-Casaus, E. Gonzalez-Parra, M. Albalate, V. Lorenzo, V. Torregrosa, E. Fernandez, C. de la Piedra, M. Rodriguez, M. Zeiler, T. Monteburini, R. M. Agostinelli, R. Marinelli, S. Santarelli, F. Bermond, C. Bagnis, C. Marcuccio, G. Soragna, M. Bruno, C. Vitale, M. Marangella, F. Martino, E. Scalzotto, M. P. Rodighiero, C. Crepaldi, C. Ronco, S. Seferi, M. Rroji, E. Likaj, M. Barbullushi, N. Thereska, E. J. Kim, J. H. Han, H. M. Koo, F. M. Doh, C. H. Kim, K. I. Ko, M. J. Lee, H. J. Oh, S. H. Han, T.-H. Yoo, K. H. Choi, S.-W. Kang, S. Uzun, S. Karadag, M. Yegen, M. Gursu, S. Ozturk, Z. Aydin, A. Sumnu, E. Cebeci, E. Atalay, R. Kazancioglu, D. Alscher, P. Fritz, J. Latus, M. Kimmel, D. Biegger, M. Lindenmeyer, C. D. Cohen, R. P. Wuthrich, S. Segerer, Y. K. Kim, H. W. Kim, H. C. Song, E. J. Choi, C. W. Yang, A. Matsuda, Y. Tayama, T. Ogawa, M. Iwanaga, S. Okazaki, M. Hatano, T. Kiba, T. Shimizu, H. Hasegawa, T. Mitarai, M. Dratwa, F. Collart, C. Verger, K. Takayanagi, T. Iwashita, C. Noiri, M. Inamura, S. Nakamura, H. Kato, M. H. Sipahioglu, F. Elmali, X. Zhang, J. Ma, A. Giuliani, L. Blanca-Martos, A. Nayak Karopadi, G. Mason, M. T. Santos, I. Fonseca, O. Santos, M. J. Rocha, M. J. Carvalho, A. Cabrita, A. Rodrigues, L. Scabbia, A. Domenici, F. Apponi, M. Tayefeh Jafari, F. Sivo, C. Falcone, G. Punzo, P. Mene, T. Yildirim, R. Yilmaz, A. Azak, M. Altindal, E. Turkmen, B. Altun, M. Duranay, Y. Erdem, M. Buyukbakkal, B. Eser, O. Yayar, Z. Ercan, A. Kali, B. Erdogan, A. Haspulat, O. Merhametsiz, G. Ulusal-Okyay, S. I. Akdag, M. D. Ayli, A. Pietrzycka, P. Miarka, E. Chowaniec, W. Sulowicz, M. Lutwin, M. Gaska, and A. Paciorek

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, medicine.medical_treatment, Urology, Medicine, business, Peritoneal dialysis
Published
2013

31. Renal histopathology

Author

E. J. Kim, J. H. Han, H. M. Koo, F. M. Doh, C. H. Kim, K. I. Ko, M. J. Lee, H. J. Oh, T.-H. Yoo, S.-W. Kang, K. H. Choi, S. H. Han, S. Assady, M. Tchirkov, R. Nasser, T. Mashiach, O. Ben Izhak, P. Housset, R. Guillemain, D. Nochy, M. Roland, C. Amrein, A. Karras, V. Boussaud, V. Pezzela, E. Thervet, S. P. Simic Ogrizovic, G. Basta Jovanovic, S. Radojevic, S. Bojic, R. Naumovic, Z. Karim, K. Cyrine, G. Rim, A. Ezzeddine, H. Hafedh, K. Hayet, B. Soumaya, O. Mondher, B. H. Fethi, E. Y. Fethi, B. A. Taieb, B. M. Hedi, B. M. Fatma, K. Adel, M. Penescu, E. Mandache, A. Zumrutdal, R. Ozelsancak, T. Canpolat, S. Barbouch, I. Mami, M. Mayara, M. Jerbi, A. Harzallah, R. Goucha, H. Ben Maiz, A. Kedher, N. Comi, P. Cianfrone, V. Piraina, R. Talarico, K. Giannakakis, G. Fuiano, G. Lucisano, K. Konat, M. Szotowska, H. Karkoszka, M. Adamczak, A. Wiecek, K. Kwiecien, O. Jercan, L. Mogoanta, I. Miller, X. Pan, J. Xu, H. Ren, W. Zhang, Y. Xu, P. Shen, X. Chen, X. Feng, and N. Chen

Subjects
Transplantation, Nephrology
Published
2013

32. Transplantation: clinical studies - A

Author

T. Yildirim, R. Yilmaz, M. Altindal, E. Turkmen, M. Arici, B. Altun, Y. Erdem, O. Guliyev, M. Erkmen Uyar, E. Tutal, Z. Bal, S. Sezer, U. Bal, B. Say n, B. Erdemir, A. O'Rourke-Potowki, N. Gauge, H. Penny, A. Cronin, S. Frame, D. J. Goldsmith, J. A. Yagan, A. Chandraker, R. M. Velickovic Radovanovic, A. Catic Djordjevic, B. Mitic, N. Stefanovic, T. Cvetkovic, N. Serpieri, F. Grosjean, G. Sileno, M. Torreggiani, V. Esposito, F. Mangione, M. Abelli, F. Castoldi, D. Catucci, C. Esposito, A. Dal Canton, A. V. Vatazin, A. B. Zulkarnaev, C. Borst, Y. Liu, J. Thoning, M. Tepel, C. Libetta, E. Margiotta, I. Borettaz, M. Canevari, C. Martinelli, E. Lainu, F. Meloni, V. Sepe, R. Miguel Costa, E. Vasquez Martul, J. Reboredo, C. Rivera, F. Simonato, G. Tognarelli, G. Daidola, E. Gallo, M. Burdese, V. Cantaluppi, L. Biancone, G. P. Segoloni, M. Priora, M. Messina, M. Tamagnone, A. Linsalata, A. Lavacca, G. Segoloni, W. Zuidema, R. Erdman, J. van de Wetering, F. Dor, J. Roodnat, E. Massey, L. Timmerman, J. IJzermans, W. Weimar, C. Sibley-Allen, R. Hilton, M. Moghul, L. Burnapp, G. Blake, T. Y. Koo, J.-S. Park, H. C. Park, G.-H. Kim, C. H. Lee, I. H. Oh, C. M. Kang, J. K. Hwang, S. C. Park, B. S. Choi, H. J. Chun, J. I. Kim, C. W. Yang, I. S. Moon, S. Van Laecke, W. Van Biesen, E. V. Nagler, Y. Taes, P. Peeters, R. Vanholder, R. Pruthi, R. Ravanan, A. Casula, M. Harber, P. Roderick, D. Fogarty, A. Cho, J.-h. Shin, H. R. Jang, J. E. Lee, W. Huh, D. J. K. Kim, H. Y. Oh, Y.-G. Kim, A. Sancho Calabuig, E. Gavela Martinez, J. Kanter Berga, S. Beltran Catalan, A. I. Avila Bernabeu, L. M. Pallardo Mateu, E. Gonzalez, N. Polanco, M. Molina, E. Gutierrez, L. Garcia Puente, A. Sevillano, E. Morales, M. Praga, A. Andres, M. Banasik, M. Boratynska, K. Koscielska-Kasprzak, D. Bartoszek, M. Myszka, S. Zmonarski, B. Nowakowska, E. Wawrzyniak, A. Halon, P. Chudoba, M. Klinger, J. Rojas-Rivera, J. M. Morales, J. Egido, C. M. Kopecky, M. Haidinger, C. Kaltenecker, M. Antlanger, G. Marsche, M. Holzer, J. Kovarik, J. Werzowa, M. Hecking, M. D. Saemann, J. M. Kim, E. S. Koh, B. H. Chung, Y. S. Kim, M. Krajewska, O. Mazanowska, D. Kaminska, M. Zabinska, B. Malkiewicz, D. Patrzalek, J. Sulowicz, S. Szostek, A. Wojas-Pelc, E. Ignacak, W. Sulowicz, V. Bellizzi, P. Calella, A. Cupisti, A. Capitanini, C. D'Alessandro, D. Giannese, A. Camocardi, G. Conte, M. Barsotti, G. Bilancio, R. Luciani, L. Locsey, I. Seres, D. Kovacs, L. Asztalos, G. Paragh, M. Wohlfahrtova, P. Balaz, S. Rokosny, P. Wohlfahrt, A. Bartonova, O. Viklicky, J. Kers, R. B. Geskus, L. J. Meijer, F. Bemelman, I. J. M. ten Berge, S. Florquin, J.-C. Hwang, M.-Y. Jiang, Y.-H. Lu, S.-F. Weng, A. Testa, G. Porto, M. Sanguedolce, B. Spoto, R. Parlongo, A. Pisano, G. Enia, G. Tripepi, C. Zoccali, N. Mamode, A. Lennerling, F. Citterio, K. Van Assche, S. Sterckx, M. Frunza, H. Jung, A. Pascalev, R. Johnson, C. Loven, T. Soleymanian, H. Keyvani, S. M. Jazayeri, Z. Fazeli, S. Ghamari, M. Mahabadi, V. Chegeni, I. Najafi, M. R. Ganji, K. M. E. Meys, J. W. Groothoff, K. Jager, F. Schaefer, B. Tonshoff, C. Mota, K. Cransberg, K. van Stralen, E. Gurluler, N. Gures, A. Alim, A. Gurkan, U. Cakir, I. Berber, R. Caluwe, E. Nagler, B. Van Vlem, A. Betkowska-Prokop, M. Kuzniewski, M. Krzanowski, I. Masson, M. Flamant, N. Maillard, E. Cavalier, O. Moranne, E. Alamartine, C. Mariat, P. Delanaye, L. L. Canas Sole, E. Iglesias Alvarez, M. C. M. C. Pastor, F. F. Moreno Flores, V. V. Abujder, F. F. Graterol, J. J. Bonet Sol, R. R. Lauzurica Valdemoros, M. Yoshikawa, K. Kitamura, K. Nakai, S. Goto, H. Fujii, T. Ishimura, M. Takeda, M. Fujisawa, S. Nishi, N. Prasad, D. Gurjer, D. Bhadauria, A. Gupta, R. Sharma, A. Kaul, M. Cybulla, M. West, K. Nicholls, J. Torras, G. Sunder-Plassmann, S. Feriozzi, S. Lo, P. Y. H. Wong, D. Ip, C. K. Wong, V. C. C. Chow, S. K. L. Mo, M. Molnar, A. Ujszaszi, M. E. Czira, M. Novak, I. Mucsi, J. M. Cruzado, S. Coelho, N. Porta, O. Bestard, E. Melilli, O. Taco, I. Rivas, J. Grinyo, L.-M. Pouteau, J.-M. N'Guyen, A. Hami, M. Hourmant, N. Ghahramani, Z. Karparvar, S. Shadrou, M. Ghahramani, J. P. Fauvel, A. Hadj-Aissa, F. Buron, E. Morelon, M. Ducher, C. Heine, P. Glander, H.-H. Neumayer, K. Budde, L. Liefeldt, N. Montero, A. C. Webster, A. Royuela, J. Zamora, M. Crespo, J. Pascual, A. Y. Adema, W. T. H. van Dorp, M. J. K. Mallat, H. W. de Fijter, Y. A. Hong, C. W. Park, Y.-S. Kim, G. Suleymanlar, Z. Uzundurukan, A. Kapuagas, I. Sencan, R. Akdag, A. Torio, V. Mas, M. J. Perez-Saez, M. Mir, A. Faura, O. Montes-Ares, M. D. Checa, D. Sawinski, J. Trofe-Clark, T. Sparkes, P. Patel, S. Goral, R. Bloom, H. J. Kim, S. J. Park, T. H. Kim, Y. W. Kim, Y. H. Kim, S. W. Kang, M. Abdel Halim, O. Gheith, T. Al-Otaibi, A. Mosaad, W. Awadeen, T. Said, P. Nair, and M. R. N. Nampoory

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, Medicine, business, Intensive care medicine
Published
2013

33. Peritoneal dialysis II

Author

O. Yayar, M. Buyukbakkal, B. Eser, T. Yildirim, Z. Ercan, B. Erdogan, A. Kali, O. Merhametsiz, A. Haspulat, I. Akdag, M. D. Ayli, T. Quach, P. Tregaskis, S. Menahem, J. Koukounaras, N. Mott, R. Walker, M. Zeiler, S. Santarelli, G. Degano, T. Monteburini, R. M. Agostinelli, R. Marinelli, E. Ceraudo, T. Grzelak, M. Kramkowska, M. Walczak, K. Czyzewska, I. Guney, K. Turkmen, R. Yazici, S. Arslan, L. Altintepe, M. Yeksan, C. Vaduva, S. Popa, M. Mota, E. Mota, W. A. H. Wan Md Adnan, N. L. Zaharan, M. Moreiras-Plaza, R. Blanco-Garcia, L. Beato-Coo, C. Cossio-Aranibar, I. Martin-Baez, M. T. Santos, I. Fonseca, O. Santos, P. Aguiar, M. J. Rocha, M. J. Carvalho, A. Cabrita, A. Rodrigues, Z. Guo, X. Lai, M. Theodoridis, S. Panagoutsos, E. Thodis, M. Karanikas, A. Mitrakas, P. Kriki, K. Kantartzi, P. Passadakis, V. Vargemezis, N. Vakilzadeh, M. Pruijm, M. Burnier, G. Halabi, P. Azevedo, M. Carvalho, S. Laplante, P. Rutherford, E. Shutov, A. Isachkina, E. Gorelova, M.-I. Troya, J. Teixido, G. Pedreira, M. Del Rio, R. Romero, J. Bonet, X. Zhang, J. Ma, Y. Kim, J.-K. Kim, Y. R. Song, S. G. Kim, H. J. Kim, S. Eloot, R. Vanholder, W. Van Biesen, J. Heaf, C. Pedersen, A. Elgborn, T. Arabaci, G. Emrem, M. Keles, A. Kizildag, F. Martino, G. Amici, M. P. Rodighiero, C. Crepaldi, C. Ronco, H. Tanaka, S. Tsuneyoshi, K. Yamasaki, Y. Daijo, N. Tatsumoto, N. Al-Hilali, N. Hussain, V. Fathy, H. Negm, M. Alhilali, A. Grzegorzewska, K. Cieszynski, A. Kaczmarek, A. Sowinska, T. Soleymanian, I. Najafi, M. R. Ganji, F. Ahmadi, F. Saddadi, M. Hakemi, M. Amini, L. N. M. N. Tong, H. N. M. N. Yongcheng, W. N. M. N. Qijun, L. N. M. N. Shaodong, A. Velioglu, M. Albaz, H. Arikan, S. Tuglular, C. Ozener, S. Bakirdogen, N. Eren, O. Mehtap, S. G. Bek, M. B. Cekmen, A. Yilmaz, M. L. L. Cabana Carcasi, A. Fernandez Ferreiro, M. Fidalgo Diaz, V. Becerra Mosquera, R. Alonso Valente, J. Buttigieg, A. Borg Cauchi, M. Rogers, L. Buhagiar, J. Farrugia Agius, M. P. Vella, E. Farrugia, J. H. Han, H. R. Kim, K. I. Ko, C. H. Kim, H. M. Koo, F. M. Doh, M. J. Lee, H. J. Oh, S. H. Han, T.-H. Yoo, S.-W. Kang, K. H. Choi, D. Sikorska, D. Frankiewicz, P. Klysz, K. Schwermer, K. Hoppe, J. Nealis, J. Kaczmarek, E. Baum, M. Wanic-Kossowska, K. Pawlaczyk, A. Oko, M. Hiss, F. Gerstein, H. Haller, F. Gueler, M. Fukasawa, T. Manabe, Q. Wan, Y. He, D. Zhu, J. Li, H. Xu, A. Oztemel, D. Pilcevic, Z. Kovacevic, D. Maksic, Z. Paunic, J. Tadic-Pilcevic, M. Mijuskovic, M. Petrovic, K. Obrencevic, V. Rabrenovic, L. Ignjatovic, B. Terzic, D. Jovanovic, C.-H. Chang, Y.-S. Chang, M. Busuioc, A. Guerraoui, A. Caillette-Beaudoin, S. K. Bahte, J. T. Kielstein, H. Polinder-Bos, M. Emmelot-Vonk, and C. Gaillard

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, medicine.medical_treatment, Urology, medicine, business, Peritoneal dialysis
Published
2013

34. Transplantation - clinical studies II

Author

I. B. Marques, R. d. M. Silva, C. E. Moraes, L. S. Azevedo, W. C. Nahas, E. David-Neto, A. Furmanczyk-Zawiska, T. Baczkowska, A. Chmura, J. Szmidt, M. Durlik, J. Joslin, P. Blaker, B. White, A. Marinaki, J. Sanderson, D. J. Goldsmith, S. Medani, C. Traynor, P. Mohan, D. Little, P. Conlon, M. Molina, E. Gonzalez, E. Gutierrez, A. Sevillano, N. Polanco, E. Morales, A. Hernandez, M. Praga, J. M. Morales, A. Andres, S. J. Park, T. H. Kim, Y. W. Kim, Y. H. Kim, S. W. Kang, A. Kujawa-Szewieczek, M. Szotowska, P. Kuczera, J. Chudek, A. Wiecek, A. Kolonko, A. Mahrova, K. Svagrova, V. Bunc, M. Stollova, V. Teplan, F. Hundt, P. van Heteren, R. Woitas, M. C. Cavallo, V. Sepe, F. Conte, P. Albrizio, A. Bottazzi, P. M. Geraci, N. Alpay, M. R. Gumber, V. B. Kute, A. V. Vanikar, H. V. Patel, P. R. Shah, D. P. Engineer, H. L. Trivedi, J. E. Golebiewska, A. Debska-Slizien, B. Rutkowski, P. Matias, A. R. Martins, L. Raposo, C. Jorge, A. Weigert, R. Birne, M. Bruges, T. Adragao, M. Almeida, M. Mendes, D. Machado, J. Masin-Spasovska, S. Dohcev, O. Stankov, S. Stavridis, S. Saidi, B. Dejanova, I. Rambabova-Busletic, P. Dejanov, G. Spasovski, K. W. Nho, D. J. Han, S.-K. Park, S. B. Kim, R. Fenoglio, E. E. Lazzarich, D. Cagna, T. Cena, N. Conti, M. Quaglia, E. Radin, C. Izzo, P. Stratta, I. H. Oh, J.-S. Park, C. H. Lee, C. M. Kang, G.-H. Kim, F. Leone, D. Lofaro, P. Gigliotti, S. Lupinacci, P. Toteda, D. Vizza, A. Perri, T. Papalia, R. Bonofiglio, P. di Loreto, L. de Silvestro, D. Montanaro, F. Martino, S. Sandrini, E. Minetti, G. Cabiddu, T. Yildirim, R. Yilmaz, E. Turkmen, A. Abudalal, M. Altindal, D. Ertoy-Baydar, Y. Erdem, V. Panuccio, R. Tripepi, G. Parlongo, M. C. Versace, R. Politi, C. Zoccali, F. Mallamaci, E. Porrini, I. Silva, J. Diaz, M. Ibernon, F. Moreso, R. Benitez, P. Delgado Mallen, J. Osorio, R. Lauzurica, A. Torres, A. Ersoy, N. Koca, T. Gullu Koca, E. Kirhan, E. Sarandol, C. Ersoy, M. Dirican, J. Milne, V. Suter, A. Mikhail, H. Akalin, O. Dizdar, J. Pascual, A. Torio, C. Garcia, J. Hernandez, M. J. Perez-Saez, M. Mir, F. Anna, M. Crespo, P. Carta, M. Zanazzi, G. Antognoli, L. Di Maria, L. Caroti, D. S. Ray, K. Mukherjee, N. P. Bohidar, A. Pattanaik, P. Das, S. Thukral, T. Kimura, T. Yagisawa, N. Ishikawa, Y. Sakuma, T. Fujiwara, A. Nukui, E. E. Gavela, A. A. Sancho, J. J. Kanter, A. A. Avila, S. S. Beltran, L. L. Pallardo, F. G. Dawoud, V. Aithal, M. Majernikova, J. Rosenberger, L. Prihodova, I. Nagyova, M. Jarcuskova, R. Roland, J. W. Groothoff, J. P. van Dijk, M. van Agteren, A. de Weerd, J. van de Wetering, J. IJzermans, M. Betjes, W. Weimar, J. Popoola, A. Reed, R. Tavarro, C. Chryssanthopoulou, I. MacPhee, M. Mayor, S. Franco, P. Jara, R. Ayala, M. G. Orue, A. Martinez, M. Martinez, N. Wasmouth, G. Arik, A. Yasar, S. Yilmaz, M. Arici, S. Bihari Bansal, S. Pokhariyal, S. Jain, S. Sethi, R. Ahlawat, V. Kher, L. S. Martins, P. Aguiar, L. Dias, I. Fonseca, A. C. Henriques, A. Cabrita, J. Davide, T. M. Sparkes, J. Trofe-Clark, P. P. Reese, D. Jakobowski, S. Goral, S. L. Doll, P. L. Abt, D. Sawinski, R. D. MBloom, B. Knap, J. Lukac, M. Lukin, I. Majcen, F. Pavlovec, A. Kandus, A. F. Bren, J. M. Kong, J. H. Jeong, J. Ahn, D. R. Lee, S. H. Son, B. C. Kim, W. Y. Choi, E. J. Whang, B. Czajka, S. Malgorzewicz, N. Panizo, M. A. Rengel, A. Vega, S. Abad, L. Tana, D. Arroyo, M. Rodriguez-Ferrero, A. Perez de Jose, J. M. Lopez-Gomez, K. Koutroutsos, J. Sackey, L. Paolini, R. Ramkhelawon, M. Chowrimootoo, D. Whelan, J. Slatinska, E. Honsova, M. Wohlfahrtova, E. Slimackova, S. B. Rajnochova, O. Viklicky, A. Yankovoy, I. S. J. Smith, E. Wylie, P. Ruiz-Esteban, V. Lopez, P. Garcia-Frias, M. Cabello, M. Gonzalez-Molina, C. Vozmediano, D. Hernandez, J. Pavlovic, D. Radivojevic, V. Lezaic, S. Simic-Ogrizovic, M. Lausevic, R. Naumovic, V. Sakhuja, S. Gundlapalli, M. Rathi, V. Jha, H. S. Kohli, A. Sharma, M. Minz, A. Nimgirova, A. Esayan, I. Kayukov, E. Zuyeva, Y. Bilen, E. Cankaya, M. Keles, E. Gulcan, M. Turkeli, B. Albayrak, A. Uyanik, R. Yildirim, N. Molitor, M. Praktiknjo, T. N. Abeygunaratne, S. Balasubramanian, R. Baker, T. Nicholson, O. Toprak, Y. Sari, S. Keceli, H. Kurt, A. Rocha, J. Malheiro, S. Pedroso, A. Henriques, C. Nihei, I. Bacelar Marques, C. A. Seguro, G. Mate, N. Martin, L. Colon, L. Casellas, D. Garangou, M. de la Torre, P. Torguet, I. Garcia, J. Calabia, M. Valles, R. Pruthi, M. Calestani, G. Leydon, R. Ravanan, P. Roderick, S. Korkmaz, and S. Gulten

Subjects
Transplantation, Nephrology
Published
2013

35. Structures: Liquid Crystals

Author

S.-W. Kang, Gautam Singh, and Satyendra Kumar

Subjects
Condensed Matter::Soft Condensed Matter, Crystallography, Materials science, Biaxial nematic, Liquid crystal, Liquid crystalline, Chemical physics, Discotic liquid crystal, Columnar phase, Thermotropic crystal, Symmetry (physics)
Abstract

Microscopic structures of the most commonly encountered thermotropic liquid crystalline phases of the calamitic, discotic, bent-core, and bimesogenic systems are described. Classification of the various phases is based on the type and the degree of orientational order, positional order, molecular organization, and the symmetry of their structures. Specific physical characteristic(s) of the liquid crystal phases which render them scientifically important and technologically useful, are also briefly addressed.

Published
2016

36. Primary and secondary glomerulonephritis I

Author

N. Miyazaki, J. Matsumoto, F. Alberici, A. Palmisano, F. Maritati, E. Oliva, C. Buzio, A. Vaglio, G. Mjoen, G. E. Norby, B. E. Vikse, E. Svarstad, B. Rune, A. Knut, M. Szymczak, J. Kuzniar, W. Kopec, Z. Marchewka, M. Klinger, P. Arrizabalaga, R. Silvarino, F. Sant, G. Espinosa, M. Sole, R. Cervera, D. Gude, S. Chennamsetty, A. Demin, V. Kozlov, I. Lisukov, O. Kotova, A. Sizikov, V. Sergeevicheva, L. Demina, O. Borjesson, M. Wendt, A. Avik, A. R. Qureshi, J. Bratt, E. J. Miller, I. Gunnarsson, A. Bruchfeld, K. Sugiyama, M. Hasegawa, K. Yamamoto, H. Hayashi, S. Koide, K. Murakami, M. Tomita, S. Yoshida, Y. Yuzawa, S. Yew, D. Jayne, K. Westman, P. Hoglund, O. Flossman, A. Mahr, R. Luqmani, J. Robson, E. Thervet, C. Levi, E. Guiard, M. Roland, D. Nochy, C. Daniliuc, L. Guillevin, L. Mouthon, C. Jacquot, A. Karras, Y. Kimura, H. Morita, H. Debiec, H. Yamada, N. Miura, S. Banno, P. Ronco, H. Imai, D. H. Shin, D. Famee, H. M. Koo, S. H. Han, K. H. Choi, T.-H. Yoo, S.-W. Kang, C. Fofi, L. Scabbia, F. Festuccia, A. Stoppacciaro, P. Mene', A. Shimizu, M. Fukui, A. MII, T. Kaneko, Y. Masuda, Y. Iino, Y. Katayama, Y. Fukuda, A. Kuroki, K. Matsumoto, T. Akizawa, R. Jurubita, G. Ismail, R. Bobeica, E. Rusu, D. Zilisteanu, A. Andronesi, O. Motoi, V. Ditoiu, I. Copaci, M. Voiculescu, M. V. Irazabal, A. Eirin, J. C. Lieske, L. H. Beck, J. J. Dillon, P. H. Nachman, S. Sethi, S. B. Erickson, D. C. Cattran, F. C. Fervenza, B. Svobodova, Z. Hruskova, I. Janatkova, E. Jancova, V. Tesar, M. S. Seo, S. H. Kwon, E. B. Lee, J. Y. You, Y. K. Hyun, S. A. Woo, M. Y. Park, S. J. Choi, J. S. Jeon, H. Noh, J. G. Kim, D. C. Han, S. D. Hwang, T. Y. Choi, S. Y. Jin, E. Loiacono, D. Defedele, M. P. Puccinelli, R. Camilla, R. Gallo, L. Peruzzi, C. Rollino, G. Beltrame, M. Ferro, L. Vergano, F. Campolo, A. Amore, R. Coppo, T. Knoop, L. Bostad, T. Leivestad, R. Bjorneklett, J. Teranishi, R. Yamamoto, Y. Nagasawa, T. Shoji, H. Iwatani, N. Okada, T. Moriyama, A. Yamauchi, Y. Tsubakihara, E. Imai, H. Rakugi, Y. Isaka, F. M. Doh, S. J. Kim, D. S. Han, Y. Suzuki, K. Matsuzaki, H. Suzuki, K. Okazaki, H. Yanagawa, M. Maiguma, M. Muto, T. Sato, S. Horikoshi, J. Novak, O. Hotta, Y. Tomino, E. Gutierrez, I. Zamora, J. Ballarin, Y. Arce, S. Jimenez, C. Quereda, T. Olea, J. Martinez-Ara, A. Segarra, C. Bernis, A. Garcia, M. Goicoechea, S. Garcia de Vinuesa, J. Rojas, M. Praga, V. Ristovska, G. Petrushevska, L. Grcevska, K. Satake, Y. Shimizu, N. Mugitani, S. Honda, K. Shibuya, A. Shibuya, M. Papale, M. T. Rocchetti, S. DI Paolo, I. V. Suriano, A. D'apollo, G. Vocino, E. Montemurno, L. Varraso, G. Grandaliano, L. Gesualdo, A. Huerta, A. S. Bomback, P. A. Canetta, J. Radhakrishnan, L. Herlitz, B. Stokes, V. D'agati, G. Markowitz, G. B. Appel, H. Mouna, B. D. Nasr, I. Mrabet, L. Ahmed, A. Sabra, F. Mohamed Ammeur, E. Mezri, S. Habib, M. Innocenti, A. Pasquariello, G. Pasquariello, P. Mattei, A. Bottai, G. Fumagalli, L. Bozzoli, S. Samoni, A. Cupisti, B. Caldin, J. Hung, L. Repizo, D. M. Malheiros, R. Barros, V. Woronik, C. Giammarresi, L. Bono, A. Ferrantelli, C. Tortorici, G. Licavoli, U. Rotolo, X. Huang, Q. Wang, M. Shi, W. Chen, Z. Liu, R. Scarpioni, L. Cantarini, A. Lazzaro, M. Ricardi, V. Albertazzi, L. Melfa, C. Concesi, D. Vallisa, L. Cavanna, G. Gungor, H. Ataseven, A. Demir, Y. Solak, M. Biyik, B. Ozturk, I. Polat, A. Kiyici, O. Ozer Cakir, H. Polat, I. Castillo, V. Carreno, A. Aguilar, R. Madero, E. Hernandez, J. Bartolome, F. Gea, R. Selgas, H. A. M. El Aggan, H. S. El Banawy, E. Wagdy, N. Tchebotareva, O. LI, I. Bobkova, L. Kozlovskaya, V. Varshavskiy, E. Golicina, Y. Chen, Z. Gong, X. Chen, L. Tang, J. Zhou, X. Cao, R. Wei, E. H. Koo, J. H. Park, H. K. Kim, M. S. Kim, H. R. Jang, J. E. Lee, W. Huh, D. J. Kim, H. Y. Oh, Y.-G. Kim, O. Eskova, M. Shvetsov, E. Golytsina, O. Popova, M. Quaglia, S. Monti, R. Fenoglio, A. Menegotto, A. Airoldi, C. Izzo, M. A. Rizzo, U. Dianzani, P. Stratta, and D. Gianfreda

Subjects
Transplantation, Nephrology
Published
2012

37. Peritoneal dialysis

Author

J. Liu, Y. Liu, Y. Xu, X. Zhao, J. Qian, B. Sun, C. Xing, R. Kanda, C. Hamada, T. Nakano, K. Wakabayashi, H. Io, S. Horikoshi, Y. Tomino, N. Ishimatsu, T. Miyamoto, H. Morimoto, J. Nakamata, R. Baba, K. Kanegae, R. Serino, N. Kabashima, Y. Otsuji, Y. Doi, M. Tamura, T. Kusumoto, K. Fukami, S.-I. Yamagishi, S. Ueda, Y. Kaida, T. Hazama, Y. Nakayama, R. Ando, N. Obara, S. Okuda, M. Matsumoto, Y. Furuno, H. Bang-Gee, L. Mazzotta, A. Rosati, A. Carlini, V. T. Henriques, E. Zangiacomi Martinez, J. C. Divino-Filho, R. Pecoits-Filho, J. A. Cardeal Da Costa, T. Gama Axelsson, B. Lindholm, J. J. Carrero, O. Heimburger, P. Stenvinkel, A. R. Qureshi, M. Akazawa, T. Uno, E. Kanda, Y. Maeda, M. Aktsiali, S. Antonopoulou, K. Tsiolaki, N. Bakirtzi, A. Patrinou, M. Georgopoulou, P. Liaveri, N. Afentakis, G. Tsirpanlis, T. Hasegawa, H. Nishiwaki, M. Hirose, D. Komukai, H. Tayama, F. Koiwa, A. Yoshimura, S. L. Lui, S. Lui, S. Yung, C. Tang, F. Ng, W. K. Lo, T. M. Chan, H. M. Koo, F. M. Doh, D. E. Yoo, H. J. Oh, T.-H. Yoo, K. H. Choi, S.-W. Kang, D. S. Han, S. H. Han, N. Fernandes, M. G. Bastos, M. R. Gianotti Franco, A. Chaoubah, M. D. Gloria Lima, S. Kang, J. Do, K. Cho, J. Park, K. Yoon, J.-B. Chen, B.-C. Cheng, T.-C. Chen, Y.-J. Su, C.-H. Wu, Y. Park, J. Jeon, M. Tsikeloudi, P. Pateinakis, K. Patsatsi, E. Manou, D. Sotiriadis, D. Tsakiris, L. Teixeira, A. Rodrigues, M. J. Carvalho, A. Cabrita, D. Mendonca, M. Bruschi, G. Candiano, L. Santucci, S. Luzio, R. Cannavo, G. M. Ghiggeri, E. Verrina, Y. Varadarajan, B. Raju, K.-H. Cho, J.-W. Park, K.-W. Yoon, T.-W. Kim, M. Kimmel, N. Braun, J. Latus, M. D. Alscher, D. Struijk, S. Van Esch, R. T. Krediet, T. Van den Beukel, T. Hoekstra, L. Tirapani, K. De Andrade Bastos, M. Bastos, F. Dekker, T. Yasuhisa, H. Kanai, K. Harada, Y. Kawai, H. Sugiyama, Y. Ito, K. Tsuruya, H. Yoshida, H. Maruyama, S. Goto, M. Nakayama, H. Nakamoto, H. Morinaga, S. Matsuo, H. Makino, M. C. DI Gioia, P. Gallar, N. Laso, I. Rodriguez, G. Cobo, A. Oliet, J. Hynostroza, J. C. Herrero, C. Mon, M. Ortiz, A. Vigil, T. Tomo, J. Portoles, S. Uta, A. M. Tato, P. Lopez-Sanchez, M. Rivera, R. Rodriguez-Pena, G. Del Peso, M. Ortega, C. Felipe, E. Tsampikaki, G. Aperis, A. Kaikis, C. Paliouras, N. Karvouniaris, M. Maragaki, P. Alivanis, B. Kortus-Gotze, T. Hoferhusch, J. Hoyer, F. Martino, M. Kaushik, M. P. Rodighiero, C. Creapldi, C. Ronco, A. Lacquaniti, V. Donato, M. R. Fazio, S. Lucisano, V. Cernaro, R. Lupica, M. Buemi, C. Aloisi, N. Bavbek Ruzgaresen, S. Secilmis, H. Yilmaz, A. Akcay, M. Duranay, N. Akalin, M. R. Altiparmak, S. Trabulus, A. S. Yalin, R. Ataman, K. Serdengecti, K. Schneider, B. Bator, B. Niko, F. Peter, C. Ulmer, L. Joerg, K. Martin, B. Dagmar, O. German, R. Fabian, D. Juergen, S. Stephan, A. Dominik, P. Fritz, B. Rettenmaier, S. Hirschburger, S. Segerer, D. Biegger, T. Lang, G. Ott, M. Habib, M. Korte, M. Hagen, F. Dor, M. Betjes, R. Zietse, C. Scharpf, T. I. Chang, D. H. Shin, D.-S. Han, H. Y. Choi, Y. K. Lee, B. S. Kim, T. H. Yoo, H. C. Park, H. Y. Lee, N. Horimoto, K. Tuji, S. Kitamura, R. Isshiki, M. Iwagami, D. Tsutsumi, Y. Mochida, K. Ishioka, M. Oka, K. Maesato, H. Moriya, T. Ohtake, S. Hidaka, S. Kobayashi, C. Higuchi, Y. Tanihata, M. Ishii, H. Sugimoto, N. Sato, A. Kyono, T. Ogawa, H. Nishimura, K. Otsuka, J.-Y. Do, C. Du Halgouet, A. Latifa, V. Anne Sophie, D. Emmanuel, R. Christine, V. Francois, T. Grzelak, L. Czyzewska-Majchrzak, M. Kramkowska, H. Witmanowski, K. Czyzewska, K. Janda, M. Krzanowski, P. Dumnicka, W. Sulowicz, M. Rroji, S. Seferi, M. Barbullushi, E. Likaj, E. Petrela, N. Thereska, G. Cabiddu, E. Dessi, A. Arceri, P. Laura, E. Manca, M. Conti, R. Cao, A. Pani, C.-T. Liao, O. Vega Vega, A. Mendoza de la Garza, R. Correa-Rotter, A. Ueda, K. Nagai, M. Morimoto, A. Hirayama, S. Owada, Y. Tonozuka, C. Saito, K. Yamagata, A. Matsuda, Y. Tayama, M. Iwanaga, C. Noiri, M. Hatano, T. Kiba, K. Kanozawa, H. Katou, H. Hasegawa, T. Mitarai, S. Ros-Ruiz, L. Fuentes-Sanchez, C. Jironda-Gallegos, E. Gutierrez-Vilches, P. Garcia-Frias, D. Hernandez-Marrero, S. Lee, X. Lai, W. Chen, Z. Guo, M. Braide, V. Cristina, S. G. Popa, M. Maria, M. Eugen, P. DI Loreto, N. Spahia, L. O. Sanchez Macias, K. I. Lares Castellanos, J. A. Hernandez Pacheco, R. Correa Rotter, A. Pedro Ventura, S. Olivia, V. Joana, F. Francisco, C. Maria Joao, C. Antonio, A. S. Rodrigues, N. Atas, Y. Erten, K. Onec, S. Inal, S. Topal, A. Akyel, B. Celik, G. U. Okyay, Y. Tavil, M. Zeiler, T. Monteburini, R. M. Agostinelli, R. Marinelli, S. Santarelli, C. Yaylaci, G. Sahin, G. Guz, S. Sindel, A. Pinho, A. Malho Guedes, A. Fragoso, H. Carreira, I. Pinto, I. Bernardo, P. Leao, B. Kusnierz-Cabala, A. Krasniak, E. Chowaniec, B. Tabor-Ciepiela, K. Turkmen, O. Ozbek, M. Kayrak, C. Samur, I. Guler, H. Z. Tonbul, K. Rusai, R. Herzog, K. Kratochwill, L. Kuster, C. Aufricht, C.-M. Meier, D. Fliser, M. K. Schilling, M. Klingele, M. Fukasawa, M. Takeda, M. Kamiyama, Y. R. Song, H. J. Kim, S. G. Kim, J.-K. Kim, J. W. Noh, J. W. Yoon, and J.-R. Koo

Subjects
Transplantation, Nephrology
Published
2012

38. AKI - Clinical

Author

E. Gok Oguz, R. Olmaz, K. Turgutalp, N. Muslu, M. A. Sungur, A. Kiykim, W. Van Biesen, J. Vanmassenhove, G. Glorieux, R. Vanholder, S. Chew, K. Forster, T. Kaufeld, J. Kielstein, T. Schilling, A. Haverich, H. Haller, B. Schmidt, P. Hu, X. Liang, Y. Chen, R. LI, F. Jiang, Z. LI, W. Shi, C. C. W. Lim, C. M. L. Chia, A. K. Tan, C. S. Tan, R. Ng, S. Subramani, A. Perez de Jose, C. Bernis Carro, R. Madero Jarabo, J. Bustamante, J. A. Sanchez Tomero, W. Chung, H. Ro, J. H. Chang, H. H. Lee, J. Y. Jung, L. Fazzari, A. Giuliani, J. Scrivano, L. Pettorini, U. Benedetto, R. Luciani, A. Roscitano, A. Napoletano, D. Coclite, E. Cordova, G. Punzo, R. Sinatra, P. Mene, N. Pirozzi, L. Shavit, R. Manilov, N. Algur, Y. Wiener-Well, I. Slotki, C. Pipili, C. S. Vrettou, K. Avrami, F. Economidou, K. Glynos, S. Ioannidou, V. Markaki, E. Douka, S. Nanas, A. De Pascalis, P. Cofano, S. Proia, A. Valletta, O. Vitale, F. Russo, E. Buongiorno, V. Filiopoulos, D. Biblaki, D. Lazarou, D. Chrysis, M. Fatourou, S. Lafoyianni, D. Vlassopoulos, O. Zakiyanov, V. Kriha, J. Vachek, J. Svarcova, T. Zima, V. Tesar, M. Kalousova, M. Kaushik, C. Ronco, D. Cruz, L. Zhang, W. Zhang, N. Chen, A. A. Ejaz, G. Kambhampati, N. Ejaz, B. Dass, V. Lapsia, A. A. Arif, A. Asmar, M. Shimada, M. Alsabbagh, R. Aiyer, R. Johnson, T.-H. Chen, C.-H. Chang, M.-Y. Chang, Y.-C. Tian, C.-C. Hung, J.-T. Fang, C.-W. Yang, Y.-C. Chen, V. Cantaluppi, A. D. Quercia, F. Figliolini, S. Giacalone, A. Pacitti, M. Gai, C. Guarena, G. Leonardi, L. Biancone, G. Camussi, G. P. Segoloni, M. De Cal, P. Lentini, A. Clementi, G. M. Virzi, E. Scalzotto, A. Lacquaniti, V. Donato, M. R. Fazio, S. Lucisano, V. Cernaro, R. Lupica, M. Buemi, I. Helvaci, E. Anik, M. Wani, D. I. Wani, D. M. A. Bhat, D. K. Banday, D. M. S. Najar, D. A. R. Reshi, D. N. A. Palla, P. Iglesias, T. Olea, C. Vega-Cabrera, M. Heras, M. A. Bajo, G. Del Peso, M. J. Arias, R. Selgas, J. J. Diez, E. Daher, P. L. Costa, E. N. S. Pereira, R. D. P. Santos, K. L. Abreu, G. Silva Junior, E. D. B. Pereira, M. Raimundo, S. Crichton, Y. Syed, J. Martin, C. Whiteley, D. Bennett, M. Ostermann, A. Gjyzari, N. Thereska, A. Koroshi, M. Barbullushi, S. Kodra, A. Idrizi, A. Strakosha, E. Petrela, J. Lemmich Smith, A. Klimenko, E. Tuykhmenev, S. Villevalde, Z. Kobalava, S. Avdoshina, E. Tyukhmenev, M. Efremovtseva, H. Hayashi, S. Suzuki, K. Kataoka, Y. Kondoh, H. Taniguchi, D. Sugiyama, K. Nishimura, W. Sato, S. Maruyama, S. Matsuo, Y. Yuzawa, D. Geraldine, F. Muriel, H. Alexandre, R. Eric, P. Fu, M. Pozzato, F. Ferrari, P. Cecere, P. Mesiano, A. Vallero, S. Livigni, F. Quarello, L. Hudier, O. Decaux, A. Haddj-Elmrabet, L. Mandart, M. Lino-Daniel, F. Bridoux, E. Renaudineau, T. Sawadogo, P. Le Pogamp, C. Vigneau, D. Famee, H. M. Koo, H. J. Oh, S. H. Han, K. H. Choi, S.-W. Kang, M. Mehdi, M. Nicolas, C. Mariat, P. Shah, V. B. Kute, A. Vanikar, M. Gumber, H. Patel, H. Trivedi, C. Manetos, S. Poulaki, E.-S. Tripodaki, A. Papastylianou, C. Routsi, K. Uchida, U. Kensuke, K. Yamagata, C. Saitou, M. Okada, G. Chita, M. Davies, Y. Veriawa, S. Naicker, P. Mukhopadhyay, D. Mukherjee, R. Mishra, M. Kar, D. Zickler, H. Wesselmann, R. Schindler, E. Gutierrez, J. Egido, A. Rubio-Navarro, I. Buendia, L. M. Blanco-Colio, O. Toldos, F. Manzarbeitia, A. De Lorenzo, R. Sanchez, M. Praga, J. A. Moreno, M. Y. Kim, N. R. Kang, H. R. Jang, J. E. Lee, W. Huh, Y.-G. Kim, D. J. Kim, S.-C. Hong, J.-S. Kim, H. Y. Oh, T. Okamoto, K. Kamata, S. Naito, H. Tazaki, S. Kan, L.-G. Anne-Kathrin, K. Matthias, T. Speer, L. Andreas, G. Heinrich, V. Thomas, A. Poppleton, F. Danilo, C.-F. Lai, V.-C. Wu, C.-C. Shiao, T.-M. Huang, K.-D. Wu, M. Bedford, C. Farmer, J. Irving, P. Stevens, F. Patera, F. Mattozzi, S. Battistoni, R. M. Fagugli, M. Y. Park, S. J. Choi, J. G. Kim, S. D. Hwang, H. Xie, H. Chen, S. Xu, Q. He, J. Liu, W. Hu, Z. Liu, M. Dalboni, R. Blaya, B. M. Quinto, R. Narciso, M. Oliveira, J. Monte, M. Durao, M. Cendoroglo, M. Batista, A. L. Hanemann, A. Liborio, A. Martins, M. C. C. Pinheiro, G. Meneses, R. De Paula Pessoa, M. Sousa, F. S. M. Bezerra, P. L. M. M. Albuquerque, J. B. Lima, C. B. Lima, M. D. S. B. Veras, T. Nemoto Matsui, C. Totoli, M. C. Cruz Andreoli, M. P. Vilela Coelho, N. K. Guimaraes de Souza, A. L. Ammirati, F. De Carvalho Barreto, B.-H. Ferraz Neto, B. Fortunato Cardoso Dos Santos, A. Abraham, G. Abraham, M. Mathew, P. M. A. Duarte, F. B. Duarte, E. M. Barros, F. Q. S. Castro, H. Palomba, I. Castro, S. R. Sousa, A. N. Jesus, T. Romano, E. Burdmann, L. Yu, S. H. Kwon, J. Y. You, Y. K. Hyun, S. A. Woo, J. S. Jeon, H. J. Noh, D. C. Han, L. Tozija, Z. Petronievic, G. Selim, I. Nikolov, O. Stojceva-Taneva, K. Cakalaroski, A. Lukasz, J. Beneke, J. Menne, M. Schiffer, N. Polanco, E. Hernandez, V. Gutierrez Millet, E. Gonzalez Monte, E. Morales, L. Francisco Javier, G.-F. Nuria, M.-G. Jose Maria, M. Bes Rastrollo, A. Angioi, M. Conti, R. Cao, A. Atzeni, G. Pili, V. Matta, E. Murgia, P. Melis, V. Binda, A. Pani, F. Thome, F. Leusin, E. Barros, C. Morsch, A. Balbinotto, C. Pilla, V. Premru, J. Buturovic-Ponikvar, R. Ponikvar, A. Marn-Pernat, B. Knap, J. Kovac, J. Gubensek, B. Kersnic, L. Krnjak, M. Prezelj, J. Granatova, M. Havrda, Z. Hruskova, K. Kratka, O. Remes, M. Mokrejsova, M. Bolkova, V. Lanska, I. Rychlik, M. D. Uniacke, R. J. Lewis, S. Harris, P. Roderick, N. Martin, K. Ulrich, B. Jan, B. Jorn, B. Reinhard, K. Jan, H. Hermann, F. Meyer Tobias, R. Leyla, M. W. Schmidt Bernhard, S. Harald, S. Jurgen, K. Tanja, S. Mario, E. Sang Hi, M. Claus, V. Frank, S. Aleksej, S. Sengul, S. Robert, W. Karin, G. Feikah, F. Menne Tobias, N. Meyer Tobias, G. Beutel, S. Fleig, J. Steinhoff, T. Meyer, C. Hafer, J. Bramstedt, V. Busch, M. Vischedyk, U. Kuhlmann, W. Ries, S. Mitzner, S. Mees, S. Stracke, J. Nurnberger, P. Gerke, M. Wiesner, B. Sucke, M. Abu-Tair, A. Kribben, N. Klause, F. Merkel, S. Schnatter, E. Dorresteijn, O. Samuelsson, R. Brunkhorst, G. Stec-Hus Registry, A. Reising, F.-C. Bange, M. Hiss, F. Vetter, S. M. Bode-Boger, J. Martens-Lobenhoffer, B. M. W. Schmidt, J. T. Kielstein, H. S. Shin, Y. S. Jung, and H. Rim

Subjects
Transplantation, Nephrology
Published
2012

39. Transplantation - clinical I

Author

M. Bonani, J. Brockmann, C. D. Cohen, T. Fehr, A. Nocito, M. Schiesser, A. L. Serra, M. Blum, M. Struker, D. F. Frey, R. P. Wuthrich, Y. W. Kim, S. J. Park, T. H. Kim, Y.-H. Kim, S. W. Kang, L. Webb, A. Casula, C. Tomson, Y. Ben-Shlomo, H. Mansour, A. Akl, E. Wafa, M. El Shahawy, R. Palma, S. Swaminathan, A. B. Irish, A. Kolonko, J. Chudek, A. Wiecek, Y. Vanrenterghem, D. Kuypers, D. V. Katrien, P. Evenepoel, K. Claes, B. Bammens, B. Meijers, M. Naesens, S. Lo, C.-K. Chan, D. Yong, P.-N. Wong, T.-H. Kwan, Y.-L. Cheng, K.-S. Fung, B.-Y. Choy, K.-F. Chau, C.-B. Leung, J. Ebben, J. Liu, S.-C. Chen, A. Collins, Y.-W. Ho, M. Abelli, A. Ferrario DI Torvajana, E. Ticozzelli, B. Maiga, A. Patane, P. Albrizio, M. Gregorini, C. Libetta, T. Rampino, P. Geraci, A. Dal Canton, M.-T. Rotter, J. Jacobi, K. Pressmar, K. Amann, K.-U. Eckardt, A. Weidemann, K. Muller, M. Stein, C. Diezemann, A. Sefrin, N. Babel, P. Reinke, T. Schachtner, C. Costa, G. A. Touscoz, F. Sidoti, F. Sinesi, S. Mantovani, S. Simeone, C. Balloco, E. Piasentin Alessio, M. Messina, G. Segoloni, R. Cavallo, R. .K. Sharma, D. A. Kaul, R. K. Gupta, A. Gupta, N. Prasad, D. Bhadhuria, K. J. Suresh, S. Benaboud, D. Prie, E. Thervet, S. Urien, C. Legendre, J.-C. Souberbielle, D. Hirt, G. Friedlander, J.-M. Treluyer, M. Courbebaisse, M. Arias, J. Campistol, J. Pascual, J. M. Grinyo, D. Hernandez, J. M. Morales, L. M. Pallardo, D. Seron, L. Senecal, A. Boucher, R. Dandavino, S. Colette, M. Vallee, J.-P. Lafrance, Y. Tung-Min, W. Min-Ju, C. Cheng-Hsu, C. Chi-Hung, S. Kuo-Hsiung, W. Mei-Chin, S. Direkze, M. Khorsavi, S. Stuart, A. Goode, G. Jones, C. Massimetti, I. Napoletano, G. Imperato, M. T. Muratore, S. Fazio, G. Pessina, F. Brescia, S. Feriozzi, K. Tanaka, K. Sakai, A. Futaki, Y. Hyoudo, M. Muramatsu, T. Kawamura, S. Shishido, S. Hara, A. Kushiyama, A. Aikawa, K. Jankowski, J. Gozdowska, D. Lewandowska, A. Kwiatkowski, M. Durlik, P. Pruszczyk, Y. Obi, N. Ichimaru, T. Kato, M. Okumi, J. Kaimori, K. Yazawa, N. Nonomura, Y. Isaka, S. Takahara, M. Aimele, R. Christophe, D. Geraldine, R. Eric, H. Alexandre, I. Masson, M. Nicolas, T. Ivan, J. Acil, T. Lise, H.-A. Aoumeur, D. Laurence, D. Pierre, C. Etienne, R. Lionel, K. Nassim, M. Emmanuel, A. Eric, M. Christophe, K. Alexandre, B. Pierre, H. Jean-Philippe, P. Dominique, L. Christophe, G. Alexei, D. Michel, P. Shah, V. B. Kute, A. Vanikar, M. Gumber, P. Modi, H. Trivedi, J. GoIebiewska, A. Debska-Slizien, B. Rutkowski, L. Domanski, G. Dutkiewicz, K. Kloda, A. Pawlik, A. Ciechanowicz, A. Binczak-Kuleta, J. Rozanski, M. Myslak, K. Safranow, K. Ciechanowski, C. S. Aline, T. Basset, X. Delavenne, E. Alamartine, C. Mariat, K. Bobrek-Lesiakowska, M. Wisniewska, M. Romanowski, M. Kurzawski, M. De Borst, L. Baia, G. Navis, S. Bakker, A. Ranghino, G. Tognarelli, E. Basso, A. M. Manzione, G. Daidola, G. P. Segoloni, T. Kimura, T. Yagisawa, N. Ishikawa, Y. Sakuma, T. Hujiwara, A. Nukui, M. Yashi, J. H. Kim, S.-S. Kim, D. J. Han, S.-K. Park, G. Randhawa, H. Patel, S. Taheri, O. Goker-Alpan, J. Ibrahim, K. Nedd, S. Shankar, H. Lein, B. Barshop, E. Boyd, M. Holida, R. Hillman, R. Mardach, N. Wienreb, B. Rever, R. Forte, A. Desai, A. Wijatyk, P. Chang, and R. Martin

Subjects
Transplantation, Nephrology
Published
2012

40. Characteristics of epiretinal membranes according to the presence or absence of posterior vitreous detachment

Author

Lee Jh, Seung-Woong Lee, Song Ee Chung, Y T Kim, and S W Kang

Subjects
Male, medicine.medical_specialty, Visual acuity, genetic structures, medicine.medical_treatment, Visual Acuity, Vitrectomy, Vitreous Detachment, Sensitivity and Specificity, Posterior vitreous detachment, Retina, Postoperative Complications, Ophthalmology, medicine, Humans, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Epiretinal Membrane, Middle Aged, medicine.disease, eye diseases, Membrane, medicine.anatomical_structure, Clinical Study, Optometry, Female, sense organs, medicine.symptom, Epiretinal membrane, business, Tomography, Optical Coherence
Abstract

The purpose of this study is to investigate the morphological features of epiretinal membrane (ERM) in the presence or absence of a posterior vitreous detachment (PVD).Retrospective observational comparative case series.This study involved 34 patients in whom the vitreoretinal relationship was confirmed during vitrectomy for treatment of ERM. We analyzed demography, direction of macular folds in fundus photographs, and foveal contours assessed by optical coherence tomography (OCT) in two groups of patients, the posterior vitreous attachment (PVA) group and the PVD group.Mean age of the 14 patients in the PVA group was 58.2 ± 8.2 years, and that of 20 patients in the PVD group was 66.7 ± 6.7 years (P=0.0023). Funduscopic examination revealed radiating folds in 57.1% of patients in the PVA group and 10% of patients in the PVD group, and a flat-shaped foveal contour was observed on OCT in 71.5% of patients in the PVA group and 25.0% of patients in the PVD group. Significant differences were observed between the PVA group and the PVD group in both direction of the macular folds (P0.01) and foveal contours (P=0.028).Patients with ERM and PVA were usually younger than 60 years. Radiating macular folds and flat foveal contour in patients with ERM are highly sensitive and specific findings indicative of PVA.

Published
2011

41. Development of genetic markers in abalone through construction of a SNP database

Author

S. W. Kang, J. B. Lee, M. K. Baek, Sharon A. Appleyard, Y. S. Han, Yongseok Lee, Y.-J. Jee, Nicholas G. Elliott, J.-H. Kang, and T.-J. Choi

Subjects
Genetics, Expressed sequence tag, food.ingredient, dbSNP, Phylogenetic tree, General Medicine, Haliotis iris, Biology, biology.organism_classification, DNA sequencing, food, Genetic marker, Animal Science and Zoology, Haliotis, Reference genome
Abstract

In the absence of a reference genome, single-nucleotide polymorphisms (SNP) discovery in a group of abalone species was undertaken by random sequence assembly. A web-based interface was constructed, and 11 932 DNA sequences from the genus Haliotis were assembled, with 1321 contigs built. Of these, 118 contigs that consisted of at least ten annotation groups were selected. The 1577 putative SNPs were identified from the 118 contigs, with SNPs in several HSP70 gene contigs confirmed by PCR amplification of an 809-bp DNA fragment. SNPs in the HSP70 gene were compared across eight abalone species. A total of 129 polymorphic sites, including heterozygote sites within and among species, were observed. Phylogenetic analysis of the partial HSP70 gene region showed separation of the tested abalone into two groups, one reflecting the southern hemisphere species and the other the northern hemisphere species. Interestingly, Haliotis iris from New Zealand showed a closer relationship to species distributed in the northern Pacific region. Although HSP genes are known to be highly conserved among taxa, the validation of polymorphic SNPs from HSP70 in this mollusc demonstrates the applicability of cross-species SNP markers in abalone and the first step towards universal nuclear markers in Haliotis.

Published
2010

43. Melanopsin expression in dopamine-melatonin neurons of the premammillary nucleus of the hypothalamus and seasonal reproduction in birds

Author

Laura J. Mauro, Sunantha Kosonsiriluk, S. W. Kang, Atsushi Iwasawa, M. E. El Halawani, and B. Leclerc

Subjects
Melanopsin, Turkeys, medicine.medical_specialty, Dopamine, Photoperiod, Immunocytochemistry, Hypothalamus, In situ hybridization, Biology, Birds, Melatonin, Pineal gland, Internal medicine, medicine, Animals, Circadian rhythm, Neurons, Tyrosine hydroxylase, Reproduction, General Neuroscience, Rod Opsins, Circadian Rhythm, medicine.anatomical_structure, Endocrinology, Gene Expression Regulation, Female, Seasons, medicine.drug
Abstract

Melanopsin (OPN4) is a photoreceptive molecule regulating circadian systems in mammals. Previous studies from our laboratory have shown that co-localized dopamine-melatonin (DA-MEL) neurons in the hypothalamic premammillary nucleus (PMM) are putatively photosensitive and exhibit circadian rhythms in DAergic and MELergic activities. This study investigates turkey OPN4x (tOPN4x) mRNA distribution in the hypothalamus and brainstem, and characterizes its expression in PMM DA-MEL neurons, using in situ hybridization (ISH), immunocytochemistry (ICC), double-label ISH/ICC, and real time-PCR. The mRNA encoding tOPN4x was found in anatomically discrete areas in or near the hypothalamus and the brainstem, including nucleus preopticus medialis (POM), nucleus septalis lateralis (SL), PMM and the pineal gland. Double ICC, using tyrosine hydroxylase (TH, the rate limiting enzyme in DA synthesis)-and OPN4x antibodies, confirmed the existence of OPN4x protein in DA-MEL neurons. Also, tOPN4x mRNA expression was verified with double ISH/ICC using tOPN4x mRNA and TH immunoreactivity. PMM and pineal gland tOPN4x mRNA expression levels were diurnally high during the night and low during the day. A light pulse provided to short day photosensitive hens during the photosensitive phase at night significantly down-regulated tOPN4x expression. The expression level of tOPN4x mRNA in PMM DA-MEL neurons of photorefractory hens was significantly lower as compared with that of short or long day photosensitive hens. The results implicate tOPN4x in hypothalamic PMM DA-MEL neurons as an important component of the photoreceptive system regulating reproductive activity in temperate zone birds.

Published
2010

44. Photoperiodic Modulation of Clock Gene Expression in the Avian Premammillary Nucleus

Author

S. W. Kang, B. Leclerc, Laura J. Mauro, M. E. El Halawani, Yupaporn Chaiseha, and Sunantha Kosonsiriluk

Subjects
Turkeys, endocrine system, medicine.medical_specialty, Time Factors, Light, Photoperiod, Endocrinology, Diabetes and Metabolism, Biology, Pineal Gland, Avian Proteins, Melatonin, Cellular and Molecular Neuroscience, Endocrinology, Internal medicine, medicine, Zeitgeber, Animals, RNA, Messenger, Circadian rhythm, Oscillating gene, In Situ Hybridization, Neurons, Reverse Transcriptase Polymerase Chain Reaction, Endocrine and Autonomic Systems, Suprachiasmatic nucleus, Brain, Immunohistochemistry, Circadian Rhythm, PER2, CLOCK, PER3, Female, Suprachiasmatic Nucleus, Microdissection, medicine.drug
Abstract

The premammillary nucleus (PMM) has been shown to contain a daily endogenous dual-oscillation in dopamine (DA)/melatonin (MEL) as well as c-fos mRNA expression that is associated with the daily photo-inducible phase of gonad growth in turkeys. In the present study, the expression of clock genes (Bmal1, Clock, Cry1, Cry2, Per2 and Per3) in the PMM was determined under short (8 : 16 h light/dark cycle) and long (16 : 8 h light/dark cycle) photoperiods relative to changes associated with the diurnal rhythm of DA and MEL. Constant darkness (0 : 24 h light/dark cycle) was used to assess the endogenous response of clock genes. In addition, light pulses were given at zeitgeber time (ZT) 8, 14 and 20 to ascertain whether clock gene expression is modulated by light pulse stimulation and therefore has a daily phase-related response. In the PMM, the temporal clock gene expression profiles were similar under short and long photoperiods, except that Per3 gene was phase-delayed by approximately 16 h under long photoperiod. In addition, Cry1 and Per3 genes were light-induced at ZT 14, the photosensitive phase for gonad recrudescence, whereas the Clock gene was repressed. Gene expression in established circadian pacemakers, the visual suprachiasmatic nucleus (vSCN) and the pineal, was also determined. Clock genes in the pineal gland were rhythmic under both photoperiods, and were not altered after light pulses at ZT 14, which suggests that pineal clock genes may not be associated with the photosensitive phase and reproductive activities. In the vSCN, clock gene expression was phase-shifted depending on the photoperiod, with apexes at night under short day length and during the day under long day length. Furthermore, light pulses at ZT 14 induced the Per2 gene, whereas it repressed the Bmal1 gene. Taken together, the changes in clock gene expression observed within the PMM were unique compared to the pineal and vSCN, and were induced by long photoperiod and light during the daily photosensitive phase; stimuli that are also documented to promote reproductive activity. These results show that Cry1 and Per3 are involved in the photic response associated with the PMM neuronal activation and are coincident with an essential circadian mechanism (photosensitive phase) controlling the reproductive neuroendocrine system.

Published
2010

45. Investigation of a set procedure for the stability of pressure control in the newly developed flow-control system at KRISS

Author

S. S. Hong, Wakil Khan, and S. W. Kang

Subjects
Outgassing, Flow control (fluid), Physics and Astronomy (miscellaneous), Constant pressure, Pressure control, Chemistry, Nuclear engineering, Nitrogen gas, Pressure Rate, Analytical chemistry, Vacuum chamber
Abstract

Korea Research Institute of Standards and Science (KRISS) has assembled a new flow-control system (FCS-705) for the study of advanced applications and calibration of different types of vacuum gauges by comparison method. This report details the measurement of the outgassing rate of the main vacuum chamber by the pressure rate of rise method. Constant pressure was generated inside the vacuum chamber by employing a dynamic flow control method. Nitrogen gas flow data was recorded to demonstrate that constant pressure was controlled in the vacuum chamber. The measurements were performed in a sequence of increasing pressures.

Published
2009

46. Structural optimization of an upper control arm, considering the strength

Author

Byoung-Cheol Song, S.-W. Kang, Young-Chul Park, and Kwon-Soon Lee

Subjects
Engineering, business.industry, Mechanical Engineering, Automotive industry, Process (computing), Aerospace Engineering, Minimum weight, Structural engineering, Durability, Control arm, Fuel efficiency, Shape optimization, Engineering design process, business
Abstract

The latest automotive components are lighter than their past counterparts, providing higher fuel efficiency and performance. Following the current trend in vehicle design, this study proposes a structural optimization method for the upper control arm of the vehicle's suspension system. The upper control arm can be designed to be lightweight with application of advanced design and material technology. In this research, the shape of the upper control arm was determined by optimization technology. The aluminium alloy Al6061M6 was developed as the steel-substitute material. Strength performance is the most important design requirement in the structural design of a control arm. In the optimization process of this study, the static strength was considered. Durability analysis was carried out to predict the fatigue life of the upper control arm. The kriging interpolation method was adopted to obtain the minimum weight that would satisfy the strength constraint. Optimum designs were obtained by ANSYS Workbench and the in-house program, EXCEL-Kriging, and the optimization results from both design programs were compared.

Published
2009

47. Allopurinol-induced aplastic anemia in a patient with chronic kidney disease

Author

B S Park, S W Kang, Yang Wook Kim, Im-Sook Song, C H Ryu, Y H Kim, Ji-Hong Shon, and S J Park

Subjects
Adult, musculoskeletal diseases, medicine.medical_specialty, Anemia, Allopurinol, Gastroenterology, hemic and lymphatic diseases, Internal medicine, medicine, Humans, Hyperuricemia, Enzyme Inhibitors, Aplastic anemia, business.industry, Anemia, Aplastic, General Medicine, medicine.disease, Pancytopenia, medicine.anatomical_structure, Nephrology, Prednisolone, Kidney Failure, Chronic, Female, Bone marrow, business, Kidney disease, medicine.drug
Abstract

Aplastic anemia is a rare complication of allopurinol use. We report an unusual case of aplastic anemia associated with allopurinol therapy for hyperuricemia in a patient with chronic kidney disease. A 37-year-old female patient diagnosed with Stage III chronic kidney disease was admitted with pancytopenia. She had a history of taking allopurinol for 5 months. Her bone marrow showed extremely decreased cellularity (< 20%) and there was no malignant cell infiltration. She was free of infections, including parvovirus B19, cytomegalovirus and Epstein-Barr virus. These results suggested a diagnosis of aplastic anemia. Allopurinol was discontinued immediately and treatment with blood transfusions and prednisolone was begun. After 6 months, the bone marrow cellularity improved to approximately 70%. Recently, it was suggested that decreased activity of multidrug resistance P-glycoprotein may play a role in acquired aplastic anemia. So we measured the inhibitory effect of allopurinol and oxypurinol on P-glycoprotein activity. But neither allopurinol nor oxypurinol inhibited P-glycoprotein activity.

Published
2009

48. Serotonergic and Catecholaminergic Interactions with Co-Localised Dopamine-Melatonin Neurones in the Hypothalamus of the Female Turkey

Author

B. Leclerc, Laura J. Mauro, M. E. El Halawani, and S. W. Kang

Subjects
Serotonin, Turkeys, medicine.medical_specialty, Epinephrine, Dopamine, Endocrinology, Diabetes and Metabolism, Hypothalamus, Tryptophan Hydroxylase, Biology, Serotonergic, Norepinephrine, Cellular and Molecular Neuroscience, Endocrinology, Internal medicine, medicine, Animals, Melatonin, Neurons, Catecholaminergic, TPH2, Tyrosine hydroxylase, Endocrine and Autonomic Systems, Reproduction, Dopaminergic, Brain, Tryptophan hydroxylase, Isoenzymes, Female, medicine.drug
Abstract

Serotonin and catecholamines (dopamine, norepinephrine, epinephrine) have important roles as neurotransmitters in avian reproduction, but their anatomical relationship to the neuroendocrine circuitry that regulates reproduction is poorly understood. Our previous studies have shown that co-localised dopamine-melatonin (DA-MEL) neurones in the avian premammillary nucleus (PMM) are active during periods of photoresponsiveness and, therefore, are potentially photosensitive neurones. Because serotonergic and catecholaminergic neurotransmitters are important regulators of reproductive function in the female turkey, we hypothesised that the serotonergic/catecholaminergic neurones within the brainstem might interact with PMM DA-MEL neurones and constitute an important circuit for reproductive function. To examine this possible interaction, the retrograde fluorescent tract tracer, 1,1'dioctadecyl-3,3,3'3'-tetramethyleindocarbocyanine perchlorate (DiI) was injected into the PMM, and combined with serotonin, tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenyl N-methyltransferse (PNMT) immunocytochemistry to reveal neuroanatomical connections. Changes in the activities of serotonergic, dopaminergic, adrenergic and noradrenergic neuronal systems projecting to the PMM were measured at different reproductive states with in situ hybridisation (ISH) techniques, using tryptophan hydroxylase 2 (TPH2) and TH mRNA expression, respectively. Cells labelled with DiI were found in anatomically discrete areas in or near the hypothalamus and the brainstem. Double immunocytochemistry confirmed that there were serotonin, DBH and PNMT fibres in close apposition to DA-MEL neurones. TPH2 mRNA expression in serotonin neurones was found in several nuclei, and its most abundant mRNA expression was seen in the nucleus Locus ceruleus of laying and incubating hens. TH mRNA expression levels in the six catecholaminegic areas labelled with DiI was measured across the different reproductive states. In the nucleus tractus solitarius (adrenergic), the highest level of TH mRNA expression was found in photorefractory hens and the lowest level in incubating hens. These observed patterns of serotonin/catecholamine neuronal distribution and their variable interactions with PMM DA-MEL neurones during different reproductive states may offer a significant neuroanatomical basis for understanding the control of avian reproductive seasonality.

Published
2009

49. Testing and analysis of fatigue behaviour in edge details: A comparative study using hot spot and structural stresses

Author

S-W Kang and M-H Kim

Subjects
Engineering, business.industry, Mechanical Engineering, Hot spot (veterinary medicine), Welding, Structural engineering, Edge (geometry), Nominal stress, Finite element method, law.invention, Stress (mechanics), law, Structural stress, business
Abstract

At present, the fatigue design of welded structures is primarily based on a nominal stress or hot spot stress (HSS) approach with a series of classified weld S-N curves. Although well accepted by major industries, the nominal stress-based fatigue design approach is relatively cumbersome in terms of securing a series of S-N curves corresponding to each class of joint types and loading modes. Moreover, it is very difficult, if not impossible, to determine the nominal stress at each structural component, particularly in complex ship structures. The HSS-based fatigue design is based on the stress at the weld toes obtained by linear or quadratic extrapolation of stresses over two or three points in front of the weld toe. Finite-element analysis is mostly applied. However, this method has a difficulty of finding a proper stress through the global model, the medium size model and the detail model of ship structure. Besides, the calculated HSS values may vary depending on the extrapolation technique used. Recently, a mesh-size insensitive structural stress (SS) definition that gives a stress state at the weld toe with a relatively large mesh size has been proposed. The SS definition is based on the elementary structural mechanics theory and provides an effective measure of a stress state in front of the weld toe. As an experimental validation of the Battelle SS method in obtaining the fatigue strength of weldments, a series of experiments are carried out for various sizes of weldments. Based on the results from this study, it is expected to achieve the development of a more precise fatigue strength evaluation technique and saving on the time required in the fatigue design of ship and offshore structures.

Published
2008

50. Rhythmic Dependent Light Induction of Gonadotrophin-Releasing Hormone-I Expression and Activation of Dopaminergic Neurones within the Premammillary Nucleus of the Turkey Hypothalamus

Author

Thomas Bakken, M. E. El Halawani, S. W. Kang, A. Thayananuphat, and James R. Millam

Subjects
Turkeys, endocrine system, medicine.medical_specialty, Light, Dopamine, Photoperiod, Endocrinology, Diabetes and Metabolism, Vasoactive intestinal peptide, Hypothalamus, Stimulation, Biology, Gonadotropin-Releasing Hormone, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Endocrinology, Internal medicine, Neural Pathways, medicine, Animals, RNA, Messenger, Neurotransmitter, Neurons, Endocrine and Autonomic Systems, Reproduction, Dopaminergic, Immunohistochemistry, Prolactin, Circadian Rhythm, Preoptic area, chemistry, Female, Proto-Oncogene Proteins c-fos, hormones, hormone substitutes, and hormone antagonists, Vasoactive Intestinal Peptide, medicine.drug
Abstract

Our previous studies using turkey hens have demonstrated that c-fos mRNA (a marker of neuronal activation) is expressed in gonadotrophin-releasing hormone-I (GnRH-I), vasoactive intestinal peptide (VIP) and dopamine (DA) neurones following electrical stimulation in the preoptic area. DA has been shown to have both stimulatory and inhibitory effects on the GnRH-I/luteinising hormone (LH), follicle-stimulating hormone (FSH) and VIP/prolactin (PRL) systems. To identify the DA neurones that mediate the stimulatory influences of photoperiod on the reproductive system, we examined c-fos mRNA induction in DA, GnRH-I, and VIP neurones in the turkey hypothalamus using a dark-interruption experimental design. A 30-min light period was provided to short day (6L : 18D) photosensitive turkeys at times when birds were responsive to light (14 h after first light) and at times when birds were unresponsive to light (8 h and 20 h after first light). The only area where DA neurones were activated when the birds were provided with light was in the nucleus premammillaris (PMM). The number of activated DA neurones was significantly greater when light was provided at 14 h (during the photoinducible phase) than at 8 h or 20 h. At 14 h, there was also an increase in the number of GnRH-I neurones activated in the area of the nucleus commissura pallii (nCPa), as well as an up-regulation of GnRH-I mRNA expression. No expression of c-fos mRNA was observed in VIP neurones in the nucleus infundibularis or up-regulation of VIP mRNA expression in any of the experimental light treatments. These results are the first evidence to demonstrate a relationship between the dopaminergic system in the PMM and the GnRH-I system in the nCPa during the photoinduction of avian reproductive activity.

Published
2007

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