54 results on '"S. van der Meulen"'
Search Results
2. pepKalc: scalable and comprehensive calculation of electrostatic interactions in random coil polypeptides.
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Kamil Tamiola, Ruud M. Scheek, Pieter S. van der Meulen, and Frans A. A. Mulder
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- 2018
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3. You've been warned: Consumer liability in Internet banking fraud.
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Nicole S. van der Meulen
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- 2013
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4. DigiNotar: Dissecting the First Dutch Digital Disaster
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Nicole S. van der Meulen
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Cybersecurity ,Europe and EU ,Global trends and risks ,Governance and rule of law ,Security policy ,Military Science - Abstract
In the middle of the night on September 2, 2011, the Dutch Minister of the Interior and Kingdom Relations held an emergency press conference. DigiNotar, a Certificate Authority (CA), had been electronically ‘broken into’ and as a result intruders had managed to generate falsified certificates. As a CA, DigiNotar issued digital certificates to secure digital communication, but as a result of the breach the authenticity of such certificates could no longer be verified. The Dutch government subsequently revoked its trust in all certificates issued by DigiNotar. This was the beginning of the first digital disaster in the Netherlands. As a pioneering disaster, this article focuses on the implications of DigiNotar as a vital case study for future scenarios of digital disaster management. The main focus of this article is on the underlying ‘weaknesses’ of the DigiNotar incident, which allowed the situation to evolve from a problem into a disaster. These include lack of oversight, lack of security attention and risk awareness and the absence of an effective mitigation strategy. By identifying and subsequently analyzing the underlying problems, this article aims to demonstrate how future situations can be better contained if sufficient attention is granted to these factors and subsequent changes are introduced.
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- 2013
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5. Trends in Demand of Urban Surface Water Extractions and in Situ Use Functions
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E. S. van der Meulen, P.R. van Oel, F. H. M. van de Ven, Nora B. Sutton, and Huub H.M. Rijnaarts
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010504 meteorology & atmospheric sciences ,Integrated urban water management ,WASS ,Water demand ,010501 environmental sciences ,Reuse ,01 natural sciences ,Ecosystem services ,Supply and demand ,Urban water resources management ,Amsterdam ,Recreation ,Environmental planning ,0105 earth and related environmental sciences ,Water Science and Technology ,Civil and Structural Engineering ,WIMEK ,Toronto ,Water Resources Management ,Sustainability ,Environmental Technology ,Milieutechnologie ,Business ,Surface water ,Water use - Abstract
Scientific literature currently lacks comprehensive understanding of urban surface water use functions. This hampers sound analysis of the demand and potential supply of these functions. This study provides a comprehensive overview of potential use functions, by integrating knowledge from ecosystem services and integrated urban water management fields. Analysis of water-related management plans for Toronto and Amsterdam shows that surface water is currently being used for a variety of functions related to nutrition, energy, water regulation, recreation, symbolic use, transportation and floating buildings. Notably, many use functions involve in situ use, rather than water extractions. Interviewed water managers and spatial planners in both cities expect demand of most use functions to increase by 2040, especially demand for thermal energy extraction, recreation and transportation. Some identified novel demands, such as climate regulation and reuse of waste products from waterway maintenance. Increasing demand is mainly driven by urban growth, climate change and sustainability ambitions. This study found urban surface water uses that are usually not acknowledged in scientific literature on urban water management. This comprehensive overview supports planning, design, and maintenance of urban surface waters, laying the foundation for future research on supply and demand of urban water use functions.
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- 2020
6. The Role of Learning Styles in Game-Based Learning
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Esmee S. van der Meulen and Pieter Wouters
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05 social sciences ,050301 education ,Game based learning ,050109 social psychology ,Verbal learning ,Education ,Learning styles ,Learning motivation ,Active learning ,Developmental and Educational Psychology ,Mathematics education ,0501 psychology and cognitive sciences ,Psychology ,Reflection (computer graphics) ,0503 education ,Visual learning ,Cognitive style - Abstract
Adapting learning to the level and preferences of learners and game-based learning have increasingly received much attention. The current study examined whether learning styles based on the Felder-Silverman classification (perception, input, processing and organization of information) influence learning in GBL. Only the input and processing scales were found to be reliable. 109 students from prevocational secondary education played a math game (proportional reasoning) after which learning gain and motivation were measured. Gameplay yielded no learning, but a median-split breakdown (prior knowledge) indicated that students with little prior knowledge did learn from the game, while those with much prior knowledge deteriorated. Subsequent multiple regression analyses revealed no predictive effect for motivation. The processing preference was predictive for learning: Students with an active processing preference performed better than students with a reflective processing preference. The discussion discusses consequences and a number of directions for follow-up research.
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- 2020
7. Perspective of relatives on restrictions applied to their family members with moderate intellectual disability
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Cees M.P.M. Hertogh, Petri J. C. M. Embregts, A. P. S. van der Meulen, E. F. Taminiau-Bloem, Verstandelijke Beperking, and Tranzo, Scientific center for care and wellbeing
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dialogue ,030506 rehabilitation ,05 social sciences ,Perspective (graphical) ,Intellectual disability ,ADULTS ,CARE ,medicine.disease ,ethics ,Developmental psychology ,restrictions ,03 medical and health sciences ,Psychiatry and Mental health ,justifications ,PEOPLE ,SUPPORT ,Developmental and Educational Psychology ,medicine ,0501 psychology and cognitive sciences ,0305 other medical science ,Psychology ,050104 developmental & child psychology - Abstract
The application of restrictions plays a great part in daily support of people with moderate intellectual disability (ID). In this study we examine the evaluation of relatives of restrictions applied to their family members with moderate ID. Relatives are key and permanent figures in the lives of people with moderate intellectual disability. Moreover, relatives in their role as representatives are authorized to make decisions in case people with moderate ID are not able to oversee the consequences of their actions. To explore relatives’ evaluation of restrictions, we conducted semi-structured interviews with 10 relatives. Qualitative analysis was carried out using a thematic approach. We found that respondents consider restrictions necessary when they promote physical well-being, safety and indistinctive, ‘normal’, appearance of their family members with ID. In applying these restrictions a ‘rules are rules’ and a ‘tailor-made rules’ approach can be discerned. The ‘tailor-made approach’ provides space for dialogue with people with moderate ID. In this dialogue the criteria of proportionality, effectiveness, and subsidiarity are helpful. In using these criteria, the application of a restriction has to be in proportion, has to lead to the desired effect, and, finally, should be as unintrusive as possible for the person concerned. As such, it is recommended that, in dialogue, support staff, people with moderate ID themselves, and their relatives seek ways to examine what kinds of restrictions are justified for people with moderate ID.
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- 2019
8. AEDAM: design of high performance multi-process systems.
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Pieter S. van der Meulen, Peter G. M. Baltus, and Ross Morley
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- 1990
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9. An Efficient Multi-Level Multi-Wire Differential Interface.
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Peter G. M. Baltus, Pieter S. van der Meulen, and Ross Morley
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- 1990
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10. Pilot study of mobile phone technology in allergic rhinitis in European countries: the MASK-rhinitis study
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Olivier Vandenplas, R. Murray, Niels H. Chavannes, Erkka Valovirta, A. Fink-Wagner, Alvaro A. Cruz, Joaquim Mullol, Aziz Sheikh, G. De Vries, T. Keil, M. Wickman, K. C. Bergmann, Pascal Demoly, Dermot Ryan, Nick A. Guldemond, Torsten Zuberbier, V. Kvedariene, Luís Nogueira-Silva, Mikael Kuitunen, A. Valiulis, G. Passalacqua, Claus Bachert, Davide Caimmi, Antonella Muraro, E Mathieu-Dupas, João Fonseca, P V Tomazic, Jean Bousquet, P. Devillier, S. Arnavielhe, Pedro Carreiro-Martins, Erik Melén, Giorgio Walter Canonica, D. Laune, Nikolaos G. Papadopoulos, M. Bewick, Ronald Dahl, A. Valero, B. Hellqvist-Dahl, Peter Hellings, B. Samolinski, L. Klimek, S. van der Meulen, J. Just, M. Morais-Almeida, David Price, Tari Haahtela, O. Spranger, A. Todo Bom, Ana Margarida Pereira, M. van Eerd, F. Portejoie, M. L. Kowalski, A. Bedbrook, Piotr Kuna, Valérie Siroux, Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon ( MACVIA-LR ), Université Montpellier 1 ( UM1 ) -World Health Organization ( WHO/OMS ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre Hospitalier Régional Universitaire de Nîmes ( CHRU Nîmes ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ) -European Innovation Partnership on Active and Healthy Ageing Reference Site, Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique ( VIMA ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Hôpital Foch [Suresnes], Department of Dermatology, Medical School-Charité - University Medicine Berlin, Forschungszentrum Jülich GmbH - Projektträger BEO, GmbH, Département pneumologie et addictologie [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Hôpital Arnaud de Villeneuve, Institut Pierre Louis d'Epidémiologie et de Santé Publique ( iPLESP ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ), Universidade de Lisboa ( ULISBOA ), Service d'allergologie [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Trousseau [APHP], Institut de Recherche en Infectiologie de Montpellier ( IRIM ), Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Allergy Department, 2nd Pediatric Clinic, Allergy & Respiratory Diseases, University of Genoa ( UNIGE ) -Department of Internal Medicine (DIMI), Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw-Faculté de Pharmacie de Paris, Center for Public Health Research ( CSISP ), University of Valencia, CIRCE, Ctr Res Energy Resources & Consumpt, Zaragoza 50018, Spain, Department of Molecular Medicine and Surgery, Karolinska Institutet [Stockholm], Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Medical School-Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Universidade de Lisboa = University of Lisbon (ULISBOA), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Università degli studi di Genova = University of Genoa (UniGe)-Department of Internal Medicine (DIMI), Medical University of Warsaw - Poland-Faculté de Pharmacie de Paris, Center for Public Health Research (CSISP), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Universidade de Lisboa (ULISBOA), Service d'Allergologie pédiatrique [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Department of Internal Medicine (DIMI)-University of Genoa (UNIGE), Health Services Management & Organisation (HSMO), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), and University of Genoa (UNIGE)-Department of Internal Medicine (DIMI)
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0301 basic medicine ,EIP on AHA ,Pediatrics ,medicine.medical_specialty ,Allergen immunotherapy ,Pathology ,Allergy ,[SDV]Life Sciences [q-bio] ,Immunology ,Pilot Projects ,Review ,Asymptomatic ,03 medical and health sciences ,Allergic ,0302 clinical medicine ,HDE ALER ,Surveys and Questionnaires ,Journal Article ,medicine ,Humans ,Immunology and Allergy ,Rhinitis ,Asthma ,Allergy Diary ,rhinorrhea ,[ SDV ] Life Sciences [q-bio] ,business.industry ,Research ,MASK-rhinitis ,Baseline data ,Conjunctivitis ,medicine.disease ,Rhinitis, Allergic ,Mobile Applications ,3. Good health ,Europe ,Mobile technology ,mobile technology ,030104 developmental biology ,030228 respiratory system ,Baseline characteristics ,allergen immunotherapy ,medicine.symptom ,business ,Cell Phone ,Nasal symptoms - Abstract
The use of Apps running on smartphones and tablets profoundly affects medicine. The MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) App (Allergy Diary) assesses allergic rhinitis symptoms, disease control and impact on patients' lives. It is freely available in 20 countries (iOS and Android platforms). AIMS: To assess in a pilot study whether (i) Allergy Diary users were able to properly provide baseline characteristics (ii) simple phenotypic characteristics based upon data captured by the Allergy Diary could be identified and (iii) information gathered by this study could suggest novel research questions. METHODS: The Allergy Diary users were classified into six groups according to the baseline data that they entered into the App: (i) asymptomatic; (ii) nasal symptoms excluding rhinorrhea; (iii) rhinorrhea; (iv) rhinorrhea plus 1-2 nasal/ocular symptoms; (v) rhinorrhea plus ≥3 nasal/ocular symptoms; and (vi) rhinorrhea plus all nasal/ocular symptoms. RESULTS: By 1 June 2016, 3260 users had registered with the Allergy Diary and 2710 had completed the baseline questionnaire. Troublesome symptoms were found mainly in the users with the most symptoms. Around 50% of users with troublesome rhinitis and/or ocular symptoms suffered work impairment. Sleep was impaired by troublesome symptoms and nasal obstruction. CONCLUSIONS: This is the first App (iOS and Android) to have tested for allergic rhinitis and conjunctivitis. A simple questionnaire administered by cell phones enables the identification of phenotypic differences between a priori defined rhinitis groups. The results suggest novel concepts and research questions in allergic rhinitis that may not be identified using classical methods info:eu-repo/semantics/publishedVersion
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- 2017
11. The INNOVATION Trial: four-year safety and effectiveness of the INCRAFT® AAA Stent-Graft System for endovascular repair
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Giovanni Coppi, Jan Brunkwall, Roberto Chiesa, Giovanni Pratesi, Carlo Pratesi, S. Van Der Meulen, Giovanni Federico Torsello, Dierk Scheinert, Pratesi, Giovanni, Pratesi, Carlo, Chiesa, Roberto, Coppi, Gioacchino, Scheinert, Dierk, Brunkwall, Jan S., Van Der Meulen, Stefaan, and Torsello, Giovanni
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Male ,Time Factors ,Endoleak ,Computed Tomography Angiography ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Settore MED/22 - Chirurgia Vascolare ,Graft Occlusion ,Aortic aneurysm ,0302 clinical medicine ,Foreign-Body Migration ,Risk Factors ,Aged ,Aged, 80 and over ,Aortic Aneurysm, Abdominal ,Aortography ,Blood Vessel Prosthesis Implantation ,Disease Progression ,Endovascular Procedures ,Female ,Germany ,Graft Occlusion, Vascular ,Humans ,Italy ,Middle Aged ,Prospective Studies ,Prosthesis Design ,Survival Analysis ,Treatment Outcome ,Blood Vessel Prosthesis ,80 and over ,Medicine (all) ,General Medicine ,Abdominal aortic aneurysm ,Aortic Aneurysm ,Clinical trial ,Blood Vessel Prosthesi ,Survival Analysi ,Cardiology and Cardiovascular Medicine ,Human ,medicine.medical_specialty ,Time Factor ,03 medical and health sciences ,Aneurysm ,Blood vessel prosthesis ,Vascular ,Multicenter trial ,medicine ,Abdominal ,Endovascular procedures ,Vascular grafting ,Endovascular Procedure ,business.industry ,Risk Factor ,Stent ,medicine.disease ,Surgery ,Prospective Studie ,Stenosis ,business ,030217 neurology & neurosurgery - Abstract
BACKGROUND: This paper reports the 4-year safety and effectiveness of the INCRAFT® AAA Stent-Graft System (Cordis Corp., Milpitas, CA, USA), an ultra-low-profile device for the treatment of abdominal aortic aneurysms. METHODS: The INNOVATION Trial is the prospective, first-in-human, multicenter trial to evaluate the safety and effectiveness of the INCRAFT® System. Patients underwent annual clinical and computed tomography angiography examination as part of the study protocol. The IN CRAF T® AAA Stent-Graft System is a customizable tri-modular design, with an ultra-low profile (14-Fr) delivery system. Patient were treated under approved protocol, the prescribed clinical and imaging follow-up at annually through 5 years. Results analyzed and adjudicated by a clinical events committee, independent core laboratory, and a data safety and monitoring board. This manuscript reports results through 4 years of follow-up. RESULTS: A total of 60 patients were enrolled in the trial, all of whom were successfully treated. Follow-up rates at 1 and 4 years were 93% (56/60) and 85% (51/60), respectively. All-cause mortality at 4 years was 17.6% and no death was AAA-, device-, or procedure-related. The secondary reintervention rate at 1 year was 4.6%, primarily the result of stent thrombosis. In total, 10 patients required 13 post-procedure interventions within 4-years of follow-up (2 to repair a type I endoleak, 4 to repair a type II endoleak, 1 for stent thrombosis, 1 for renal stenosis, 1 for aneurysm enlargement, 2 for limb migration and 2 for prosthesis stenosis or occlusion). There were 4 cases (10%) of aneurysm enlargement reported at the 4 year follow-up. At 4 years, 38 out of 39 patients were free from type I and III endoleaks. There were no proximal type I or type III endoleaks at 4-year follow-up. Core laboratory evaluation of the postoperative imaging studies indicated absence of endograft migration while a single fracture was demonstrated without any clinical sequelae. CONCLUSIONS: The INCRAFT® AAA Stent-Graft System provides a minimally invasive and durable solution for patients undergoing EVAR that has been associated with a low frequency of device-related events through 4 years of follow-up.
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- 2017
12. INSIST: Interactive Simulation in Smalltalk.
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Pieter S. van der Meulen
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- 1987
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13. EXIST: an interactive VLSI architectural environment.
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Pieter S. van der Meulen, Ming-Der Huang, Uzi Bar-Gadda, Eva Lee, and Peter G. M. Baltus
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- 1988
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14. Improving Continuously Variable Transmission Efficiency With Extremum Seeking Control
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F. van der Sluis, S. van der Meulen, FE Frans Veldpaus, B. de Jager, M Maarten Steinbuch, E. van der Noll, Control Systems Technology, and Mechanical Engineering
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Engineering ,Variator ,business.industry ,Open-loop controller ,Control engineering ,Nonlinear control ,Optimal control ,Clamping ,Control and Systems Engineering ,Robustness (computer science) ,Control theory ,Torque ,Electrical and Electronic Engineering ,business ,Continuously variable transmission - Abstract
The design of an efficiency optimal controller for the variator in a vehicular continuously variable transmission is studied. A conventional controller aims at tracking a prescribed reference for the transmission ratio and at preventing damage, but does not address efficiency. Sufficiently accurate models for the efficiency as function of the clamping forces are not available, whereas measurement of the efficiency requires extra sensors. In this brief, a controller is proposed that improves the efficiency without needing extra sensors. The maps between the clamping forces (input) and the efficiency or the speed ratio (output) are studied with test rig experiments. These maps exhibit a maximum, but the location of this maximum is uncertain. So, an extremum seeking controller is developed. This controller can adapt the input to maximize the output, without needing a model. Experiments show that this approach is feasible and that a conventional controller is outperformed. A robustness analysis for disturbances indicates that these are effectively handled.
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- 2012
15. Effects of irrigation and plastic mulch on soil properties on semi-arid abandoned fields
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L. H. Cammeraat, E. S. van der Meulen, L. Nol, and Earth Surface Science (IBED, FNWI)
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Soil management ,Hydrology ,No-till farming ,Soil structure ,Soil biodiversity ,Soil retrogression and degradation ,Soil Science ,Environmental science ,Soil conservation ,Plastic mulch ,Soil quality - Abstract
The Guadalentín Basin in Spain is one of the driest areas of Europe and has problems with high evaporation rates, and high risks of desertification exist including soil quality loss and soil erosion. Farmers in this semi-arid region use polyethylene covers on their irrigated croplands to reduce evaporation in order to enhance crop yield. When farmers abandon the acres, they leave the plastic covers on the fields. Up to now research has been concentrating on the effects of plastic covers on crop yield and microclimate under these covers but there is little known about the effects of plastic covers and irrigation on soil quality, erosion susceptibility and hydrology after abandonment of these fields. The research question in this paper is: How do the former irrigation practices and plastic soil covers affect organic Carbon content, aggregate stability, hydrological properties and erosion susceptibility? Organic Carbon content and aggregate stability are important soil quality parameters that are easy to measure. Beside these two parameters, soil crusting, infiltration rates and sediment yields have been determined for a set of irrigated fields that have been abandoned at different times (up to 20 years) and where plastic covers have been used. The properties of these fields were compared to control sites with comparable periods of abandonment and substrate, but where only classical rain fed cropping systems have been applied. It was expected that leaving plastic remains in the soil after abandonment would be harmful to soil quality and would lower infiltration. The first associations with seeing the plastic are those of garbage and pollution. In fact, most of the indicators of soil quality considered in this survey turned out to be better or the same on the fields where irrigation and plastic covers had been used, when compared to control fields. Organic Carbon contents were up to 40% higher on fields with plastic sheet remains and soil aggregates were more stabile. Fields where plastic had been mixed with the soil by tillage showed lower erosion susceptibilities.
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- 2006
16. Coarticulation within and between syllables by children with developmental apraxia of speech
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S. van der Meulen, Lian Nijland, and Ben Maassen
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Speech and Hearing ,Linguistics and Language ,medicine ,Developmental apraxia ,Psychology ,medicine.disease ,Apraxia ,Coarticulation ,Language and Linguistics ,Linguistics - Abstract
Dans le cadre theorique des modeles de production de la parole, l'A. teste l'hypothese de la syllabe (Levelt et Wheeldon, 1994) lors d'apraxie developpementale de la parole (ADP), developpee chez des enfants, en manipulant la frontiere syllabique dans le materiel oral
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- 2001
17. Financial Identity Theft : Context, Challenges and Countermeasures
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Nicole S. van der Meulen and Nicole S. van der Meulen
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- Identity theft
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The existence of financial identity theft in the United States, and its (gradual) spread to other areas of the world, increases the need to understand how identity theft occurs and how perpetrators of the crime manage to take advantage of developments within contemporary society. This book aims to provide such an understanding through an in-depth comparative analysis which illustrates how states, financial service providers, consumers, and others facilitate the occurrence of financial identity theft in the United States and the Netherlands.
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- 2011
18. Consumers
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Nicole S. van der Meulen
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- 2011
19. Financial Service Providers
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Nicole S. van der Meulen
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Credit card ,Service delivery framework ,business.industry ,Identity theft ,Service level objective ,Service level requirement ,Service provider ,Public relations ,business ,Money laundering ,Financial services - Abstract
The driving force behind financial identity theft is the acquisition of financial assets. Money is the main motivator. Perpetrators of financial identity theft predominantly acquire these financial assets from financial service providers. This demonstrates the vital value of financial service providers in the overall problem of financial identity theft. The significance of financial service providers is evident; yet, the role and associated responsibility of financial service providers is often a source of conflict and inconsistency. This conflict centers around the question of whether financial service providers embody the role of victim, villain, or both with respect to identity theft. Throughout the literature, especially in the past, financial service providers have received empathy due to financial losses suffered as a result of identity theft. To many, financial service providers are the true victims of financial identity theft. Through the rise of critical academics and interest groups, the potential facilitation, or the villain aspect, of financial service providers stepped out of the ‘victim’s’ shadow. Since the acknowledgement of the facilitation of financial identity theft by financial service providers gained more prominence, the business practices used to realize such facilitation also became the object of increased scrutiny. Financial service providers predominately include banks and credit card companies. Other relevant actors included in this chapter are supervisory organs and consumer reporting agencies since their involvement in the financial world, and therefore their inclusion in this chapter, assists in the development of a more comprehensive image of the relevant interactions in the financial services sector. Furthermore, their inclusion is also vital for the background descriptions of various developments with regard to business practices. This chapter reviews business practices based on three different phases including the acquisition of clients, the application process, and the account activity of existing clients. The first two aspects are particularly relevant for the potential facilitation of true name fraud, whereas the last phase predominantly concerns account takeover.
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- 2011
20. State as Provider
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Nicole S. van der Meulen
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Service (business) ,Identification (information) ,business.industry ,Internet privacy ,Provider Edge ,Birth certificate ,business ,Private sector ,Personally identifiable information ,Financial services ,Social Security number - Abstract
Besides its function as protector of the people, the state also maintains a function as provider, at least since the early modern state (early nineteenth century). As provider, the state is responsible for the establishment of an identification infrastructure to serve as a framework for the provision of (social) services, and also to administer other aspects of daily life such as taxes, healthcare, education, employment of citizens, and others. Paul Schwartz captures the intricate connection between the service administration and its need for personal information. As Schwartz writes, “[t]he state gathers information because distribution of social services is impossible without detailed information on the citizen as client, customer, or simply person to be controlled.” Moreover, the identification infrastructure established by the state also becomes the framework used in, for example, the financial services sectors. This makes the identification infrastructure important for both the public and the private sector. This chapter provides an overview of the main components of the identification infrastructure in both the United States and the Netherlands. The main components include identification information, ‘identification’ numbers, identification documents, and instruments used for electronic identification or authentication.
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- 2011
21. Financial Identity Theft
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Nicole S. van der Meulen
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Identity theft ,Business ,Computer security ,computer.software_genre ,computer - Published
- 2011
22. From Piece to Puzzle
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Nicole S. van der Meulen
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Interdependence ,Credit card ,Metaphor ,business.industry ,media_common.quotation_subject ,Process tracing ,Identity theft ,Money laundering ,business ,Data science ,Financial services ,media_common ,Variety (cybernetics) - Abstract
The idea of a jigsaw puzzle is a suitable metaphor for the problem of financial identity theft. The previous five chapters provide an in-depth and detailed overview of the individual pieces of the puzzle, or rather the facilitating factors of financial identity theft. This chapter, in contrast, takes a step back to observe the entire puzzle, or the broad picture, in an effort to develop an opportunity structure. Ronald V. Clarke uses the notion of a crime opportunity structure to demonstrate the interdependent relationship between crime opportunity and a variety of societal aspects. These include socio-economic structure, including demographics and geography, as well as lifestyle/routine activity and physical environment. All of these aspects influence the core of the crime opportunity structure which contains the victims, targets, and facilitators. Since the opportunity structure takes a comprehensive approach to the social context of crime, its construction for financial identity theft must contain both the overarching features of all facilitating factors as well as an understanding of the underlying mechanisms which nurture them. This is precisely why the usage of the process tracing approach was appropriate to gain valuable background information about the underlying mechanisms which established the (potential) facilitating factors as well as the process of facilitation of financial identity theft itself.
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- 2011
23. Definitional Dilemmas
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Nicole S. van der Meulen
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- 2011
24. Introduction
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Nicole S. van der Meulen
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- 2011
25. The Others
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Nicole S. van der Meulen
- Published
- 2011
26. Mandatory Adoption of IFRS and Analysts? Forecasts Information Properties
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Inder K. Khurana, S. van der Meulen, Christof Beuselinck, and Philip Joos
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Actuarial science ,Offset (computer science) ,Earnings ,business.industry ,Information processing ,Accounting ,Information environment ,business ,Private information retrieval - Abstract
This study examines the properties of the information contained in analysts’ earnings forecasts for mandatory IFRS adopters in Europe for the period 2003-07. We find a significant increase in the precision of both public and private information after switching to IFRS, especially for forecasts pertaining to 2006 and later. However, we are unable to detect a change in the consensus among financial analysts after the mandatory adoption of IFRS. These results suggest that the higher percentage increase in the precision of common information is offset by a proportionate increase in the precision of private information such that consensus among analysts does not change. When exploring analyst-specific precision in more detail, we find that the analysts who are following firms in more than one European country experience the largest post-IFRS improvement in private information precision. These results hold after controlling for factors that are shown in prior research to be correlated with analysts’ information precision measures. Taken together, our results suggest that mandatory adoption of IFRS had a significant and positive effect on the information processing of financial analysts but this did not occur homogeneously across analysts.
- Published
- 2010
27. Mandatory IFRS Reporting and Stock Price Informativeness
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Inder K. Khurana, Philip Joos, S. van der Meulen, and Christof Beuselinck
- Subjects
Surprise ,business.industry ,media_common.quotation_subject ,Synchronicity ,Accounting ,Sample (statistics) ,Business ,Information environment ,Stock return ,Eu countries ,Private information retrieval ,Stock price ,media_common - Abstract
In this paper, we examine whether mandatory adoption of IFRS influences the flow of firm-specific information and contributes to stock price informativeness as measured by stock return synchronicity. Using a constant sample of 1,904 mandatory IFRS adopters in 14 EU countries for the period 2003-2007, we find a V-shaped pattern in synchronicity around IFRS adoption, which is consistent with IFRS disclosures revealing new firm-specific information in the adoption period (i.e., a reduction of synchronicity) and subsequently lowering the surprise of future disclosures (i.e., an increase in synchronicity). We also find mandatory IFRS adoption increases analysts’ ability to incorporate industry-level information into stock price. However, we are unable to detect a reduction in the private information advantage enjoyed by institutional owners post-IFRS adoption. Moreover, we find the synchronicity effects to be more pronounced for firms in countries with larger differences in local GAAP relative to IFRS. Overall, our evidence yields novel insights on the consequences of mandatory IFRS adoption by investigating its effect on stock price informativeness and the distinctive roles played by a firm’s information environment.
- Published
- 2009
28. The Emergence Of Slow Food
- Author
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Hielke S. Van Der Meulen
- Published
- 2008
29. Fixed Structure Feedforward Controller Tuning Exploiting Iterative Trials, Applied to a High-Precision Electromechanical Servo System
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OH Okko Bosgra, S. van der Meulen, and R. Tousain
- Subjects
Iterative method ,Computer science ,Iterative learning control ,Linear system ,Feed forward ,Open-loop controller ,Control engineering ,Quadratic function ,Servomechanism ,Optimal control ,law.invention ,Tracking error ,law ,Control theory ,Convex optimization - Abstract
In this paper, the feedforward controller design problem for high-precision electromechanical servo systems that execute finite time tasks is addressed. The presented procedure combines the selection of the fixed structure of the feedforward controller and the optimization of the controller parameters on the basis of measurement data from iterative trials. A linear parameterization of the feedforward controller in a two-degree- of-freedom control architecture is chosen, which for a linear time-invariant (LTI) plant results in a feedforward controller that is applicable to a class of motion profiles as well as in a convex optimization problem with the objective function being a quadratic function of the tracking error. Optimization by iterative trials results in the controller parameter values that are optimal with respect to the actual plant, which leads to a high tracking performance. The use of iterative trials in general outperforms techniques that are based on a detailed a priori plant model only, whereas the fixed structure of the feedforward controller, i.e., the approximative inverse plant model, guarantees a high tracking performance for a class of motion profiles, unlike for example iterative learning control (ILC). Experimental results on a high-precision wafer stage illustrate the procedure.
- Published
- 2007
30. The Influence of Specific Accounting Differences on the Choice Between IFRS or US GAAP
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Marleen Willekens, S Van der Meulen, and Ann Gaeremynck
- Subjects
Competition (economics) ,medicine.medical_specialty ,Mark-to-market accounting ,business.industry ,Fair value ,Earnings quality ,medicine ,Generally Accepted Accounting Principles (United States) ,Accounting ,business ,Historical cost ,Capital market ,Positive accounting - Abstract
Due to the increased competition on capital markets and given the global importance of US markets, IFRS and US GAAP are competing to become the world standards set. Although comparable in many aspects, IFRS and US GAAP still differ in accounting for some transactions. This paper addresses the question whether specific accounting differences between IFRS and US GAAP determine the individual firm's accounting standard preference. The results show that firms prefer that accounting regime that offers them the largest flexibility (i.e. less disclosure or more measurement options) on relevant accounting items (e.g. R&D expenditures). Furthermore, the flexibility in measurement seems to result in accounting numbers that are significantly valued by investors.
- Published
- 2006
31. Étiologies, pronostic et traitement des ascites chyleuses du cirrhotique
- Author
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S. Van Der Meulen-Reboul, Hélène Rigole, C. Turrière, J.-P. Cristol, François Blanc, D. Larrey, and Pascal Perney
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Gastroenterology ,Internal Medicine - Published
- 2007
32. Sedimentary stratigraphy of Eocene sheetflood deposits, Southern Pyrenees, Spain
- Author
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S. van der Meulen
- Subjects
Tectonics ,Stratigraphy ,Geochemistry ,Sediment ,Geology ,Alluvium ,Sedimentary rock ,Sedimentation ,Petrology ,Total thickness - Abstract
The Eocene Monllobat Formation of the southern Pyrenees accumulated under continental (non-marine) conditions. The total thickness of 180 m consists of seven cycles, defined by coarse member concentrations (often sheets) at the bases. The lateral extent of the sheets defines the fixed positions of eight parallel-trending alluvial systems, separated by narrow zones of fine sediment.Sheetflooding dominated the sedimentation of these eight contemporaneous alluvial systems. The sediment was supplied from the rising axial zone of the Pyrenees. The cycles were caused by variations in tectonic activity. The positions and forms of coarse members were locally determined by contemporaneous faulting and folding of the alluvium.
- Published
- 1986
33. Einige Eigentümlichkeiten der Kriegserzählung
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J. S. van der Meulen
- Abstract
„Soldat“, „Armee“ und „Krieg“ sind drei Begriffe, die leicht als zusammengehorig erkannt werden. Verweisend auf jeweils eine Rolle, eine Organisation und ein (institutionelles) Geschehen, setzen sie einander voraus und implizieren sich gegenseitig. Zusammen bilden sie ein kulturelles Thema, eine Gesamtheit von Bedeutungen, wofur ich, aus Grunden, die noch verstandlich werden durften, den Begriff „Krieg“ als Nenner bevorzuge.
- Published
- 1982
34. Circulating levels of endogenous complement inhibitors correlate inversely with complement consumption in systemic lupus erythematosus.
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van der Meulen S, Monahan RC, Gelderman KA, van Kooten C, Teng YKO, Huizinga TWJ, Steup-Beekman GM, and Trouw LA
- Abstract
Systemic lupus erythematosus (SLE) is marked by excessive complement activation, contributing to tissue damage. Complement activation can be detected in many organs including the skin, kidney, and brain. The involvement of the central nervous system is particularly relevant to understanding neuropsychiatric SLE (NPSLE), one of the poorest understood manifestations of SLE for which no biomarkers are available. We studied the levels of complement inhibitors in SLE in relation to disease activity and as possible biomarkers to identify NPSLE. Serum levels of complement inhibitors C1-inhibitor (C1-INH), C4b-binding protein (C4BP), Factor I, and Factor H were measured in 345 SLE patients (including 102 with NPSLE) and 108 healthy controls. Compared with controls, SLE patients had higher C1-INH and C4BP but lower Factor I and H levels. All inhibitors positively correlated with total C3 and C4 levels. While correlating with the SLE Disease Activity Index (SLEDAI), no distinction in inhibitor levels was found between SLE and NPSLE patients. Over time, C1-INH and Factor H levels normalized, but no significant changes were observed for C4BP and Factor I. In SLE the levels of circulating complement inhibitors are inversely correlated to complement consumption but do not serve as biomarkers for NPSLE., (© 2024 The Author(s). European Journal of Immunology published by Wiley‐VCH GmbH.)
- Published
- 2024
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35. Differences in avidity of anti-post-translationally modified protein antibodies in mouse models and rheumatoid arthritis patients: not one-size-fits-all.
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van der Meulen S, Zhang L, van Veenendaal JMF, van der Woude D, and Trouw LA
- Subjects
- Animals, Mice, Humans, Antibody Affinity, Arthritis, Rheumatoid immunology, Disease Models, Animal, Protein Processing, Post-Translational, Autoantibodies immunology
- Abstract
Competing Interests: Competing interests: LAT is mentioned as inventor on a patent describing the methods to detect anti-CarP antibodies.
- Published
- 2024
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36. Commentary: Commentary: Antibodies against multiple post-translationally modified proteins aid in diagnosis of autoimmune hepatitis and associate with complete biochemical response to treatment.
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van den Beukel MD, Stoelinga AEC, van der Meer AJ, van der Meulen S, Zhang L, Tushuizen ME, van Hoek B, and Trouw LA
- Abstract
Competing Interests: LT is listed as an inventor on a patent on the detection of anti-CarP autoantibodies. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
- Published
- 2023
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37. Antibodies against multiple post-translationally modified proteins aid in diagnosis of autoimmune hepatitis and associate with complete biochemical response to treatment.
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van den Beukel MD, Stoelinga AEC, van der Meer AJ, van der Meulen S, Zhang L, Tushuizen ME, van Hoek B, and Trouw LA
- Abstract
Background: (Auto)immune mediated and cholestatic liver disease (AILD) includes autoimmune hepatitis (AIH), primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). Especially AIH is characterized by the presence of autoantibodies and elevated serum immunoglobulins. In rheumatoid arthritis, autoantibodies against post-translational modifications (PTMs) such as citrullination (Cit) and carbamylation (CarP) are used as diagnostic and prognostic markers, respectively. We studied the presence of six anti-PTM antibodies in patients with the three AILDs and non-AILD., Methods: Antibodies against six PTMs (malondialdehyde-acetaldehyde adducts (MAA), advanced glycation end-products (AGE), CarP, acetylation (AL), Cit, and nitration (NT)) were tested in sera of patients with AILD ( n = 106), non-AILD ( n = 101) and compared with healthy controls (HC) ( n = 100). Levels and positivity were correlated with clinical and biochemical features in a well-defined cohort of untreated AIH patients., Results: Anti-PTM antibodies were more often detectable in sera from AILD patients compared with HCs (anti-MAA: 67.9% vs. 2.0%, anti-AGE: 36.8% vs. 4.0%, anti-CarP: 47.2% vs. 5.0% and anti-AL: 18.9% vs. 5.0%). In untreated AIH, time to complete biochemical response (CBR) was associated with anti-MAA, anti-AGE, anti-CarP and anti-AL antibodies. Significantly more patients with at least three anti-PTM antibodies attained CBR at 12 months of treatment (13 vs. 3 p = 0.01)., Conclusion: Anti-PTM antibodies are frequently present in AILD. The presence of anti-MAA, anti-AGE and anti-CarP antibodies correlates with the presence of AIH within this cohort. In AIH, harboring at least three anti-PTM antibody responses is positively associated with CBR. Determination of anti-PTM antibodies in liver disease may have diagnostic and prognostic value., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 van den Beukel, Stoelinga, van der Meer, van der Meulen, Zhang, Tushuizen, van Hoek and Trouw.)
- Published
- 2023
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38. Riboswitch RS thiT as a Molecular Tool in Lactococcus lactis.
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Hernández-Ortega EP, van der Meulen S, Kuijpers LJ, and Kok J
- Subjects
- Green Fluorescent Proteins genetics, Thiamine metabolism, Thiamine Pyrophosphate genetics, Thiamine Pyrophosphate metabolism, Lactococcus lactis genetics, Lactococcus lactis metabolism, Riboswitch genetics
- Abstract
Previous RNA sequencing has allowed the identification of 129 long 5' untranslated regions (UTRs) in the Lactococcus lactis MG1363 transcriptome. These sequences potentially harbor cis -acting riboswitches. One of the identified extended 5' UTRs is a putative thiamine pyrophosphate (TPP) riboswitch. It is located immediately upstream of the thiamine transporter gene thiT ( llmg_0334 ). To confirm this assumption, the 5'-UTR sequence was placed upstream of the gene encoding the superfolder green fluorescent protein (sfGFP), sfgfp , allowing the examination of the expression of sfGFP in the presence or absence of thiamine in the medium. The results show that this sequence indeed represents a thiamine-responsive TPP riboswitch. This RNA-based genetic control device was used to successfully restore the mutant phenotype of an L. lactis strain lacking the major autolysin gene, acmA . The L. lactis thiT TPP riboswitch (RS
thiT ) is a useful molecular genetic tool enabling the gradual downregulation of the expression of genes under its control by adjusting the thiamine concentration. IMPORTANCE The capacity of microbes with biotechnological importance to adapt to and survive under quickly changing industrial conditions depends on their ability to adequately control gene expression. Riboswitches are important RNA-based elements involved in rapid and precise gene regulation. Here, we present the identification of a natural thiamine-responsive riboswitch of Lactococcus lactis, a bacterium used worldwide in the production of dairy products. We used it to restore a genetic defect in an L. lactis mutant and show that it is a valuable addition to the ever-expanding L. lactis genetic toolbox.- Published
- 2022
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39. Physician Modified Low Profile Endograft for Endovascular Repair of Juxtarenal Abdominal Aortic Aneurysms in Patients with Small Access Vessels.
- Author
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Paludetto G, Van der Meulen S, Ouriel K, and Patarca R
- Abstract
Introduction: Urgent or emergency treatment of patients with abdominal aortic aneurysms that are anatomically unsuitable for conventional repair because of short proximal necks, small diameters and access vessel calcification, and high risk for open repair can be performed with commercially available branched or fenestrated aortic endografts or physician modified stent grafts., Report: A technique is described for modification and successful implantation of a commercially available standard aortic stent graft with a low profile main body in two patients at high risk for open repair, with small access vessels and requiring uni- or bilateral renal artery fenestration for juxtarenal aneurysm repair., Discussion: Based on two case experiences, the use of physician modified off the shelf endografts appears to be a feasible and effective alternative to fenestrated endovascular repair in patients with juxtarenal abdominal aortic aneurysms at high risk for open surgical repair. Studies comparing effectiveness of the different options, including chimney/snorkel technique and debranching, are warranted., (© 2021 The Authors.)
- Published
- 2021
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40. Aortoiliac remodeling and 5-year outcome of an ultralow-profile endograft.
- Author
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Torsello G, Pratesi G, van der Meulen S, and Ouriel K
- Subjects
- Aged, Aged, 80 and over, Aorta, Abdominal diagnostic imaging, Aorta, Abdominal physiopathology, Aortic Aneurysm, Abdominal diagnostic imaging, Aortic Aneurysm, Abdominal physiopathology, Blood Vessel Prosthesis Implantation adverse effects, Clinical Trials as Topic, Endovascular Procedures adverse effects, Female, Humans, Iliac Artery diagnostic imaging, Iliac Artery physiopathology, Male, Middle Aged, Postoperative Complications etiology, Postoperative Complications physiopathology, Prosthesis Design, Retrospective Studies, Risk Factors, Time Factors, Treatment Outcome, Aorta, Abdominal surgery, Aortic Aneurysm, Abdominal surgery, Blood Vessel Prosthesis, Blood Vessel Prosthesis Implantation instrumentation, Endovascular Procedures instrumentation, Iliac Artery surgery, Stents, Vascular Remodeling
- Abstract
Background: Remodeling of the aortoiliac anatomy is a challenge to the long-term performance of stent grafts for endovascular aneurysm repair. Changes in vessel diameter and length can result in loss of seal at attachment sites, limb disunion, or kinking, with the development of high-pressure endoleaks, migration, or limb occlusion. The aim of this study was to assess the durability and conformability of the ultralow-profile INCRAFT AAA endograft (Cordis Corporation, Milpitas, Calif) during 5-year follow-up., Methods: From 2010 to 2011, there were 60 patients (median age, 74 years; range, 60-94 years) with intact abdominal aortic aneurysms who were enrolled in the INNOVATION trial to evaluate the safety, effectiveness, and durability of the INCRAFT AAA device. Clinical and technical success was assessed with protocol-specified, monitored follow-up clinic visits and core laboratory-assessed computed tomography (CT) at 1 month, 6 months, and 12 months after implantation and annually through 5 years thereafter. Diameter and angulation changes at the proximal aortic neck and diameter changes at the iliac attachment zones were measured in addition to the standard CT assessments., Results: Significant aortoiliac remodeling was observed throughout long-term follow-up after endovascular aneurysm repair. Proximal aortic neck diameter 15 mm below the lowest main renal artery increased from 23.5 ± 2.5 mm at 1 month to 27.3 ± 2.8 mm at 5 years (P = .002). Neck dilation >5 mm was observed in 8 of 38 patients with 5-year CT studies (21%). The aortic neck straightened, with angulation decreasing from 34 ± 14 degrees preoperatively to 31 ± 11 degrees at 1 month (P < .001) and to 20 ± 12 degrees at 5 years (P = .018). Straightening of the neck was most prominent in patients who presented with a high degree of preoperative angulation (r = 0.61; P < .001). Between 1 month and 5 years, iliac attachment zone diameter increased from 13.5 ± 1.9 mm to 15.0 ± 2.4 mm on the right (P = .002) and from 13.9 ± 2.3 mm to 16.8 ± 2.7 mm on the left (P < .001). During 5 years, 9 of 72 (13%) iliac arteries enlarged >5 mm. There was a significant relationship between main body oversizing and aortic neck enlargement (r = 0.42; P = .009). No similar association was observed between iliac limb oversizing and iliac dilation over time (r = 0.10 and P = .549, right side; r = 0.14 and P = .400, left side). There were no aneurysm-related deaths in the series. There were two type IA endoleaks, both of which were present on the 1-month CT scan and associated with challenging aortic neck anatomy. No patient experienced endograft migration or rupture through 5 years. Type IB endoleaks occurred in two patients, both accompanied by iliac artery dilation and loss of seal. Stent fracture occurred in two struts of the bare transrenal stent of one patient, without loss of fixation or seal. One patient experienced graft limb occlusion and was observed without intervention. There were three patients (5%) with aneurysm sac enlargement (>5 mm) through 5 years, each of whom had type II endoleak., Conclusions: Significant aortoiliac remodeling occurs after endograft implantation, including proximal aortic neck dilation, straightening of the neck, and iliac artery enlargement. The ultralow-profile INCRAFT device adapted well to these changes, with acceptably low 5-year rates of device-related endoleaks, endograft migration, and limb occlusion., (Copyright © 2018 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.)
- Published
- 2019
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41. The INNOVATION Trial: four-year safety and effectiveness of the INCRAFT® AAA Stent-Graft System for endovascular repair.
- Author
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Pratesi G, Pratesi C, Chiesa R, Coppi G, Scheinert D, Brunkwall JS, van der Meulen S, and Torsello G
- Subjects
- Aged, Aged, 80 and over, Aortic Aneurysm, Abdominal diagnostic imaging, Aortic Aneurysm, Abdominal mortality, Aortography methods, Blood Vessel Prosthesis Implantation adverse effects, Blood Vessel Prosthesis Implantation mortality, Computed Tomography Angiography, Disease Progression, Endoleak etiology, Endovascular Procedures adverse effects, Endovascular Procedures mortality, Female, Foreign-Body Migration etiology, Germany, Graft Occlusion, Vascular etiology, Humans, Italy, Male, Middle Aged, Prospective Studies, Prosthesis Design, Risk Factors, Survival Analysis, Time Factors, Treatment Outcome, Aortic Aneurysm, Abdominal surgery, Blood Vessel Prosthesis, Blood Vessel Prosthesis Implantation instrumentation, Endovascular Procedures instrumentation
- Abstract
Background: This paper reports the 4-year safety and effectiveness of the INCRAFT® AAA Stent-Graft System (Cordis Corp., Milpitas, CA, USA), an ultra-low-profile device for the treatment of abdominal aortic aneurysms., Methods: The INNOVATION Trial is the prospective, first-in-human, multicenter trial to evaluate the safety and effectiveness of the INCRAFT® System. Patients underwent annual clinical and computed tomography angiography examination as part of the study protocol. The INCRAFT® AAA Stent-Graft System is a customizable tri-modular design, with an ultra-low profile (14-Fr) delivery system. Patient were treated under approved protocol, the prescribed clinical and imaging follow-up at annually through 5 years. Results analyzed and adjudicated by a clinical events committee, independent core laboratory, and a data safety and monitoring board. This manuscript reports results through 4 years of follow-up., Results: A total of 60 patients were enrolled in the trial, all of whom were successfully treated. Follow-up rates at 1 and 4 years were 93% (56/60) and 85% (51/60), respectively. All-cause mortality at 4 years was 17.6% and no death was AAA-, device-, or procedure-related. The secondary reintervention rate at 1 year was 4.6%, primarily the result of stent thrombosis. In total, 10 patients required 13 post-procedure interventions within 4-years of follow-up (2 to repair a type I endoleak, 4 to repair a type II endoleak, 1 for stent thrombosis, 1 for renal stenosis, 1 for aneurysm enlargement, 2 for limb migration and 2 for prosthesis stenosis or occlusion). There were 4 cases (10%) of aneurysm enlargement reported at the 4 year follow-up. At 4 years, 38 out of 39 patients were free from type I and III endoleaks. There were no proximal type I or type III endoleaks at 4-year follow-up. Core laboratory evaluation of the postoperative imaging studies indicated absence of endograft migration while a single fracture was demonstrated without any clinical sequelae., Conclusions: The INCRAFT® AAA Stent-Graft System provides a minimally invasive and durable solution for patients undergoing EVAR that has been associated with a low frequency of device-related events through 4 years of follow-up.
- Published
- 2017
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42. Pilot study of mobile phone technology in allergic rhinitis in European countries: the MASK-rhinitis study.
- Author
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Bousquet J, Caimmi DP, Bedbrook A, Bewick M, Hellings PW, Devillier P, Arnavielhe S, Bachert C, Bergmann KC, Canonica GW, Chavannes NH, Cruz AA, Dahl R, Demoly P, De Vries G, Mathieu-Dupas E, Finkwagner A, Fonseca J, Guldemond N, Haahtela T, Hellqvist-Dahl B, Just J, Keil T, Klimek L, Kowalski ML, Kuitunen M, Kuna P, Kvedariene V, Laune D, Pereira AM, Carreiro-Martins P, Melén E, Morais-Almeida M, Mullol J, Muraro A, Murray R, Nogueira-Silva L, Papadopoulos NG, Passalacqua G, Portejoie F, Price D, Ryan D, Samolinski B, Sheikh A, Siroux V, Spranger O, Todo Bom A, Tomazic PV, Valero A, Valovirta E, Valiulis A, VandenPlas O, van der Meulen S, van Eerd M, Wickman M, and Zuberbier T
- Subjects
- Conjunctivitis diagnosis, Europe, Humans, Mobile Applications trends, Pilot Projects, Research trends, Rhinitis, Allergic classification, Surveys and Questionnaires, Cell Phone trends, Rhinitis, Allergic diagnosis
- Abstract
Background: The use of Apps running on smartphones and tablets profoundly affects medicine. The MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) App (Allergy Diary) assesses allergic rhinitis symptoms, disease control and impact on patients' lives. It is freely available in 20 countries (iOS and Android platforms)., Aims: To assess in a pilot study whether (i) Allergy Diary users were able to properly provide baseline characteristics (ii) simple phenotypic characteristics based upon data captured by the Allergy Diary could be identified and (iii) information gathered by this study could suggest novel research questions., Methods: The Allergy Diary users were classified into six groups according to the baseline data that they entered into the App: (i) asymptomatic; (ii) nasal symptoms excluding rhinorrhea; (iii) rhinorrhea; (iv) rhinorrhea plus 1-2 nasal/ocular symptoms; (v) rhinorrhea plus ≥3 nasal/ocular symptoms; and (vi) rhinorrhea plus all nasal/ocular symptoms., Results: By 1 June 2016, 3260 users had registered with the Allergy Diary and 2710 had completed the baseline questionnaire. Troublesome symptoms were found mainly in the users with the most symptoms. Around 50% of users with troublesome rhinitis and/or ocular symptoms suffered work impairment. Sleep was impaired by troublesome symptoms and nasal obstruction., Conclusions: This is the first App (iOS and Android) to have tested for allergic rhinitis and conjunctivitis. A simple questionnaire administered by cell phones enables the identification of phenotypic differences between a priori defined rhinitis groups. The results suggest novel concepts and research questions in allergic rhinitis that may not be identified using classical methods., (© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2017
- Full Text
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43. Plasmid Complement of Lactococcus lactis NCDO712 Reveals a Novel Pilus Gene Cluster.
- Author
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Tarazanova M, Beerthuyzen M, Siezen R, Fernandez-Gutierrez MM, de Jong A, van der Meulen S, Kok J, and Bachmann H
- Subjects
- Anti-Bacterial Agents pharmacology, Bacterial Proteins genetics, Conjugation, Genetic, Copper pharmacology, DNA, Bacterial, Drug Resistance, Bacterial genetics, Genes, Bacterial, Lactococcus lactis drug effects, Lactococcus lactis ultrastructure, Multigene Family, Nisin pharmacology, Sequence Analysis, DNA, Species Specificity, Fimbriae, Bacterial genetics, Lactococcus lactis genetics, Plasmids genetics
- Abstract
Lactococcus lactis MG1363 is an important gram-positive model organism. It is a plasmid-free and phage-cured derivative of strain NCDO712. Plasmid-cured strains facilitate studies on molecular biological aspects, but many properties which make L. lactis an important organism in the dairy industry are plasmid encoded. We sequenced the total DNA of strain NCDO712 and, contrary to earlier reports, revealed that the strain carries 6 rather than 5 plasmids. A new 50-kb plasmid, designated pNZ712, encodes functional nisin immunity (nisCIP) and copper resistance (lcoRSABC). The copper resistance could be used as a marker for the conjugation of pNZ712 to L. lactis MG1614. A genome comparison with the plasmid cured daughter strain MG1363 showed that the number of single nucleotide polymorphisms that accumulated in the laboratory since the strains diverted more than 30 years ago is limited to 11 of which only 5 lead to amino acid changes. The 16-kb plasmid pSH74 was found to contain a novel 8-kb pilus gene cluster spaCB-spaA-srtC1-srtC2, which is predicted to encode a pilin tip protein SpaC, a pilus basal subunit SpaB, and a pilus backbone protein SpaA. The sortases SrtC1/SrtC2 are most likely involved in pilus polymerization while the chromosomally encoded SrtA could act to anchor the pilus to peptidoglycan in the cell wall. Overexpression of the pilus gene cluster from a multi-copy plasmid in L. lactis MG1363 resulted in cell chaining, aggregation, rapid sedimentation and increased conjugation efficiency of the cells. Electron microscopy showed that the over-expression of the pilus gene cluster leads to appendices on the cell surfaces. A deletion of the gene encoding the putative basal protein spaB, by truncating spaCB, led to more pilus-like structures on the cell surface, but cell aggregation and cell chaining were no longer observed. This is consistent with the prediction that spaB is involved in the anchoring of the pili to the cell., Competing Interests: A patent pertaining to the use of strains expressing lactococcal pili was filed by TIFN. The affiliations to TIFN and NIZO food research do not alter our adherence to PLOS ONE policies on sharing data and materials.
- Published
- 2016
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44. T-REx: Transcriptome analysis webserver for RNA-seq Expression data.
- Author
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de Jong A, van der Meulen S, Kuipers OP, and Kok J
- Subjects
- Bacillus subtilis genetics, Gene Expression Profiling methods, Gene Expression Regulation, Bacterial, Internet, Sequence Analysis, RNA methods
- Abstract
Background: Transcriptomics analyses of bacteria (and other organisms) provide global as well as detailed information on gene expression levels and, consequently, on other processes in the cell. RNA sequencing (RNA-seq) has over the past few years become the most accurate method for global transcriptome measurements and for the identification of novel RNAs. This development has been accompanied by advances in the bioinformatics methods, tools and software packages that deal with the analysis of the large data sets resulting from RNA-seq efforts., Results: Based on years of experience in analyzing transcriptome data, we developed a user-friendly webserver that performs the statistical analysis on the gene expression values generated by RNA-seq. It also provides the user with a whole range of data plots. We benchmarked our RNA-seq pipeline, T-REx, using a case study of CodY mutants of Bacillus subtilis and show that it could easily and automatically reproduce the statistical analysis of the cognate publication. Furthermore, by mining the correlation matrices, k-means clusters and heatmaps generated by T-REx we observed interesting gene-behavior and identified sub-groups in the CodY regulon., Conclusion: T-REx is a parameter-free statistical analysis pipeline for RNA-seq gene expression data that is dedicated for use by biologists and bioinformaticians alike. The tables and figures produced by T-REx are in most cases sufficient to accurately mine the statistical results. In addition to the stand-alone version, we offer a user-friendly webserver that only needs basic input ( http://genome2d.molgenrug.nl ).
- Published
- 2015
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45. Bacillus subtilis biosensor engineered to assess meat spoilage.
- Author
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Daszczuk A, Dessalegne Y, Drenth I, Hendriks E, Jo E, van Lente T, Oldebesten A, Parrish J, Poljakova W, Purwanto AA, van Raaphorst R, Boonstra M, van Heel A, Herber M, van der Meulen S, Siebring J, Sorg RA, Heinemann M, Kuipers OP, and Veening JW
- Subjects
- Bacillus subtilis chemistry, Bacteriocins genetics, Bacteriocins metabolism, Fluorescent Dyes, Gene Expression Profiling, Peptides, Cyclic genetics, Peptides, Cyclic metabolism, Plasmids, Synthetic Biology, Volatile Organic Compounds, Bacillus subtilis genetics, Bacillus subtilis metabolism, Biosensing Techniques methods, Genetic Engineering methods, Meat analysis
- Abstract
Here, we developed a cell-based biosensor that can assess meat freshness using the Gram-positive model bacterium Bacillus subtilis as a chassis. Using transcriptome analysis, we identified promoters that are specifically activated by volatiles released from spoiled meat. The most strongly activated promoter was PsboA, which drives expression of the genes required for the bacteriocin subtilosin. Next, we created a novel BioBrick compatible integration plasmid for B. subtilis and cloned PsboA as a BioBrick in front of the gene encoding the chromoprotein amilGFP inside this vector. We show that the newly identified promoter could efficiently drive fluorescent protein production in B. subtilis in response to spoiled meat and thus can be used as a biosensor to detect meat spoilage.
- Published
- 2014
- Full Text
- View/download PDF
46. Multiple actin binding domains of Ena/VASP proteins determine actin network stiffening.
- Author
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Gentry BS, van der Meulen S, Noguera P, Alonso-Latorre B, Plastino J, and Koenderink GH
- Subjects
- Actins chemistry, Animals, Binding Sites, Cell Adhesion Molecules chemistry, Cell Adhesion Molecules genetics, Mice, Microfilament Proteins chemistry, Microfilament Proteins genetics, Mutation, Phosphoproteins chemistry, Phosphoproteins genetics, Protein Binding, Protein Multimerization, Actin Cytoskeleton chemistry, Actins metabolism, Cell Adhesion Molecules metabolism, Elastic Modulus, Microfilament Proteins metabolism, Phosphoproteins metabolism, Protein Interaction Domains and Motifs
- Abstract
Vasodilator-stimulated phosphoprotein (Ena/VASP) is an actin binding protein, important for actin dynamics in motile cells and developing organisms. Though VASP's main activity is the promotion of barbed end growth, it has an F-actin binding site and can form tetramers, and so could additionally play a role in actin crosslinking and bundling in the cell. To test this activity, we performed rheology of reconstituted actin networks in the presence of wild-type VASP or mutants lacking the ability to tetramerize or to bind G-actin and/or F-actin. We show that increasing amounts of wild-type VASP increase network stiffness up to a certain point, beyond which stiffness actually decreases with increasing VASP concentration. The maximum stiffness is 10-fold higher than for pure actin networks. Confocal microscopy shows that VASP forms clustered actin filament bundles, explaining the reduction in network elasticity at high VASP concentration. Removal of the tetramerization site results in significantly reduced bundling and bundle clustering, indicating that VASP's flexible tetrameric structure causes clustering. Removing either the F-actin or the G-actin binding site diminishes VASP's effect on elasticity, but does not eliminate it. Mutating the F-actin and G-actin binding site together, or mutating the F-actin binding site and saturating the G-actin binding site with monomeric actin, eliminates VASP's ability to increase network stiffness. We propose that, in the cell, VASP crosslinking confers only moderate increases in linear network elasticity, and unlike other crosslinkers, VASP's network stiffening activity may be tuned by the local concentration of monomeric actin.
- Published
- 2012
- Full Text
- View/download PDF
47. Evidence of motor programming deficits in children diagnosed with DAS.
- Author
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Nijland L, Maassen B, and van der Meulen S
- Subjects
- Adult, Analysis of Variance, Apraxias complications, Child, Child, Preschool, Female, Humans, Male, Motor Activity, Apraxias physiopathology, Articulation Disorders etiology
- Abstract
In this study the hypothesis of motor programming involvement in developmental apraxia of speech (DAS) was investigated by studying articulatory compensation. Five children with DAS and 5 normally speaking children (age 5;0 [years;months] to 6;10), and 6 adult women produced utterances in a normal speaking condition and in a bite-block condition in which the mandible was kept in a fixed position. Throughout the utterances, the course of the second formant was used to determine articulatory compensation and the effect of the bite block on anticipatory coarticulation. Results showed that the bite-block condition in normally speaking children, like in adult women, did not affect the extent of anticipatory coarticulation. In the speech of children with DAS, the bite block had large effects on coarticulatory patterns and on vowel quality, which, contrary to expectations, had improved. These results are interpreted as a clear demonstration of deficient motor programming in DAS.
- Published
- 2003
- Full Text
- View/download PDF
48. Planning of syllables in children with developmental apraxia of speech.
- Author
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Nijland L, Maassen B, Van Der Meulen S, Gabreëls F, Kraaimaat FW, and Schreuder R
- Subjects
- Child, Child, Preschool, Female, Humans, Male, Phonetics, Sound Spectrography, Speech Acoustics, Speech Production Measurement, Apraxias complications, Apraxias diagnosis, Developmental Disabilities complications
- Abstract
The aim of the present study was to investigate whether children with developmental apraxia of speech (DAS) show a deficit in planning syllables in speech production. Six children with DAS and six normally speaking (NS) children produced high- and low-frequency of occurrence syllable utterances, in which the syllable structure was systematically manipulated in an otherwise unchanging phoneme sequence. Anticipatory coarticulation, using second formant trajectories, and durational structure were analysed. The results showed stronger coarticulation in the children with DAS when compared to the normally speaking children. but in contrast to our expectations, in neither group was a systematic effect of syllable structure on the second format trajectory found. Effects of syllable structure did emerge for durational structure in that durational adjustments were found in the segments of the second syllable. These adjustments were less systematic in children with DAS when compared to normally speaking children. Furthermore, at the prosodic level, normally speaking children showed metrical contrasts that were not realized by the children with DAS. The latter results are interpreted as evidence for a problem in the planning of syllables in speech production of children with DAS, in particular concerning prosodic aspects, which is discussed in relation to the automation of speech production.
- Published
- 2003
- Full Text
- View/download PDF
49. Coarticulation patterns in children with developmental apraxia of speech.
- Author
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Nijland L, Maassen B, Van der Meulen S, Gabreels F, Kraaimaat FW, and Schreuder R
- Subjects
- Child, Child, Preschool, Female, Humans, Male, Phonetics, Severity of Illness Index, Speech Acoustics, Apraxias diagnosis
- Abstract
The aim of this study was to enhance our insight into the underlying deficit in developmental apraxia of speech (DAS). In particular, the involvement of planning and/or programming of speech movements in context was tested by analysing coarticulatory cohesion. For this purpose, second formant frequency measurements were conducted in repetitions of nonsense utterances ([[symbol: see text]] C = /s,x,b,d/; V = /i.a.u/), and compared across nine children with DAS, six normally speaking (NS) children and six adult women. The results showed both intra- and intersyllabic anticipatory coarticulation in NS children and adult women, in which the intersyllabic coarticulation was stronger in NS children than in adult women. The children with DAS showed more variability as compared to NS children, made, on average, less distinction between the vowels, and showed individually idiosyncratic coarticulation patterns. These results are discussed in the light of a delay as well as a deviance of speech development in children with DAS.
- Published
- 2002
- Full Text
- View/download PDF
50. Coarticulation within and between syllables by children with developmental apraxia of speech.
- Author
-
Maassen B, Nijland L, and Van Der Meulen S
- Published
- 2001
- Full Text
- View/download PDF
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