279 results on '"S. a. Leo"'
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2. Knowledge-based expert system in manufacturing planning: state-of-the-art review.
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S. P. Leo Kumar
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- 2019
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3. Finite Element Analysis of Chip Formation in Micro-Milling Operation
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S. P., Leo Kumar, primary and D., Avinash, additional
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- 2020
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4. Automation of tool path generation in multi-process micromachine tool for micromachining of prismatic and rotational parts.
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S. P. Leo Kumar
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- 2018
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5. State of The Art-Intense Review on Artificial Intelligence Systems Application in Process Planning and Manufacturing.
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S. P. Leo Kumar
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- 2017
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6. Experimental biocompatibility investigations of Ti–6Al–7Nb alloy in micromilling operation in terms of corrosion behavior and surface characteristics study
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Kumar, S. P. Leo and Avinash, D.
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- 2019
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7. Feature-based modelling and process parameters selection in a CAPP system for prismatic micro parts.
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S. P. Leo Kumar, J. Jerald, and Somasundaram Kumanan
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- 2015
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8. Process parameters optimization for micro end-milling operation for CAPP applications.
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S. P. Leo Kumar, J. Jerald, Somasundaram Kumanan, and Aniket Nargundkar
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- 2014
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9. Meta-choices in ranking knowledge-based organizations
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D. Laise, I. M. Coniglio, G. Iazzolino, S. Di Leo, and C. Daraio
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Knowledge visualization ,knwoledge visualizaztion ,quantification ,multi-criteria ,efficiency analysis ,intellectual capital ,universities ,Computer science ,Management science ,Benchmarking ,Management Science and Operations Research ,General Business, Management and Accounting ,Human capital ,Intellectual capital ,Structural capital ,Relational capital ,Quantification ,Multi-criteria ,Efficiency analysis ,Intellectual Capital ,Universities ,Satisficing ,Performance measurement ,Performance indicator - Abstract
PurposeThe purpose of this paper is to address the issue of knowledge visualization and its connection with performance measurement from an epistemological point of view, considering quantification and measurement not just as technical questions but showing their relevant implications on the management decision-making of knowledge-based organizations.Design/methodology/approachThis study proposes a theoretical contribution that combines two lines of research for identifying the three main meta-choices problems that arise in the multidimensional benchmarking of knowledge-based organizations. The first is the meta-choice problem related to the choice of the algorithm used (Iazzolino et al., 2012; Laise et al., 2015; Daraio, 2017a). The second refers to the choice of the variables to be included in the model (Daraio, 2017a). The third concerns the choice of the data on which the analyses are carried out (Daraio, 2017a).FindingsThe authors show the interplay existing among the three meta-choices in multidimensional benchmarking, considering as key performance indicators intellectual capital, including Human Capital, Structural Capital and Relational Capital, and performances, evaluated in financial and non-financial terms. This study provides an empirical analysis on Italian Universities, comparing the ranking distributions obtained by several efficiency and multi-criteria methods.Originality/valueThis study demonstrates the difficulties of the “implementation problem” in performance measurement, related to the subjectivity of results of the evaluation process when there are many evaluation criteria, and proposes the adoption of the technologies of humility related to the awareness that we can only achieve “satisficing” results.
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- 2021
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10. Experimental investigation and optimisation of process parameters in micro-electrical discharge machining.
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J. Jerald, Somasundaram Kumanan, S. P. Leo Kumar, and H. V. Chandrakar
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- 2013
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11. AN IMPROVED DATA PROTECTION TECHNIQUE TO SECURE A PUBLIC CLOUD ENVIRONMENT
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L. Jayasimman and S Hendry Leo Kanickam
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General Computer Science ,Computer science ,business.industry ,Computational Mechanics ,Data Protection Act 1998 ,Cloud computing ,Computer security ,computer.software_genre ,business ,Engineering (miscellaneous) ,computer - Published
- 2020
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12. Development and preliminary evaluation of a communication skills training programme for hospital physicians by a specialized palliative care service: the ‘Teach to Talk’ programme
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Silvia Tanzi, L. De Panfilis, Giovanna Artioli, S. Di Leo, S. Alquati, and Massimo Costantini
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Service (systems architecture) ,Palliative care ,Communication training ,Health Personnel ,media_common.quotation_subject ,education ,lcsh:Medicine ,Education ,03 medical and health sciences ,0302 clinical medicine ,Complex intervention ,Physicians ,business.product_line ,Humans ,Quality (business) ,030212 general & internal medicine ,Set (psychology) ,media_common ,Medical education ,lcsh:LC8-6691 ,lcsh:Special aspects of education ,Communication ,lcsh:R ,General Medicine ,Communication skills training ,Advanced cancer ,Hospitals ,Oncology ,030220 oncology & carcinogenesis ,Public hospital ,Psychology ,business ,Training program ,Research Article - Abstract
Background There is widespread agreement about the importance of communication skills training (CST) for healthcare professionals caring for cancer patients. Communication can be effectively learned and improved through specific CST. Existing CSTs have some limitations with regard to transferring the learning to the workplace. The aim of the study is developing, piloting, and preliminarily assessing a CST programme for hospital physicians caring for advanced cancer patients to improve communication competences. Methods This is a Phase 0-I study that follows the Medical Research Council framework; this paper describes the following sections: a literature review on CST, the development of the Teach to Talk training programme (TtT), the development of a procedure for assessing the quality of the implementation process and assessing the feasibility of the implementation process, and the pilot programme. The study was performed at a 900-bed public hospital. The programme was implemented by the Specialized Palliative Care Service. The programme was proposed to 19 physicians from 2 departments. Results The different components of the training course were identified, and a set of quality indicators was developed. The TtT programme was implemented; all the physicians attended the lesson, videos, and role-playing sessions. Only 25% of the physicians participated in the bedside training. It was more challenging to involve Haematology physicians in the programme. Conclusions The programme was completed as established for one of the two departments in which it was piloted. Thus, in spite of the good feedback from the trainees, a re-piloting of a different training program will be developed, considering in particular the bed side component. The program should be tailored on specific communication attitude and believes, probably different between different specialties.
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- 2020
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13. Efficacy and safety of Dimethyl fumarate in comparison with conventional therapy for psoriasis: an Italian real‐world clinical experience
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E, Pezzolo, S, Cazzaniga, S, Di Leo, L, Naldi, and Andrea, Zanca
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Infectious Diseases ,Fumarates ,Italy ,Dimethyl Fumarate ,Humans ,Psoriasis ,Dermatology ,Immunosuppressive Agents - Published
- 2022
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14. Impact of the COVID‐19 pandemic on melanoma diagnosis
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S Di Leo, A Eccher, A Gatti, Paolo Gisondi, Giampiero Girolomoni, M Pizzolato, Francesco Bellinato, Simone Cazzaniga, Luigi Naldi, D Saraggi, Stefano Piaserico, and M Brunelli
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2019-20 coronavirus outbreak ,Skin Neoplasms ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,MEDLINE ,Dermatology ,lockdown ,surgery ,Pandemic ,melanoma ,Humans ,Medicine ,Letters to the Editor ,610 Medicine & health ,Pandemics ,Letter to the Editor ,Melanoma diagnosis ,COVID-19 ,SARS-CoV-2 ,business.industry ,Melanoma ,medicine.disease ,Virology ,Infectious Diseases ,business - Published
- 2021
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15. Author response for 'Relation of endothelial and cardiac autonomic function with left ventricle diastolic function in patients with type II diabetes mellitus'
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Eleonora Ruscio, Dario Pitocco, Antonio Bisignani, Gessica Ingrasciotta, Saverio Tremamunno, Antonio De Vita, Gaetano Antonio Lanza, Monica Filice, Angelo Villano, Tamara Felici, V Melita, Gaetano Emanuele Rizzo, Linda Tartaglione, Salvatore Emanuele Ravenna, and Mauro A S Di Leo
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Autonomic function ,Type ii diabetes ,medicine.medical_specialty ,medicine.anatomical_structure ,Ventricle ,business.industry ,Internal medicine ,medicine ,Cardiology ,Diastolic function ,In patient ,business - Published
- 2021
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16. Reverse Transcription–Polymerase Chain Reaction Testing on Filter Paper–Dried Serum for Laboratory-Based Dengue Surveillance—American Samoa, 2018
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Tyler M. Sharp, Catherine A. Montalbo, Emily J Curren, Brad J. Biggerstaff, William Thane Hancock, Aifili John Tufa, Marc Fischer, June S. Vaifanua-Leo, Carolyn V. Gould, and Susan L. Hills
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Serum ,Suspected dengue ,Reference laboratory ,Dengue virus ,medicine.disease_cause ,Sensitivity and Specificity ,Dengue fever ,Dengue ,Virology ,medicine ,Humans ,Serologic Tests ,Filter paper ,Reverse Transcriptase Polymerase Chain Reaction ,business.industry ,Outbreak ,Articles ,medicine.disease ,American Samoa ,Reverse transcription polymerase chain reaction ,Infectious Diseases ,American samoa ,Population Surveillance ,Parasitology ,business - Abstract
Laboratory-based surveillance for arboviral diseases is challenging in resource-limited settings. We evaluated the use of filter paper–dried sera for detection of dengue virus (DENV) RNA during an outbreak in American Samoa. Matched liquid and filter paper–dried sera were collected from patients with suspected dengue and shipped to a reference laboratory for diagnostic testing. RNA was extracted from each sample and tested for DENV RNA by real-time reverse transcription-polymerase chain reaction (RT-PCR). Of 18 RT-PCR–positive liquid specimens, 14 matched filter paper–dried specimens were positive for a sensitivity of 78% (95% CI, 55–91%). Of 82 RT-PCR–negative liquid specimens, all filter paper–dried specimens were negative for a specificity of 100% (95% CI, 96–100%). Shipping of filter paper–dried specimens was similarly timely but less expensive than shipping liquid sera. Using filter paper–dried serum or blood can be a cost-effective and sustainable approach to surveillance of dengue and other arboviral diseases in resource-limited settings.
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- 2020
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17. Comparative Analysis of Hash Authentication Algorithms and ECC Based Security Algorithms in Cloud Data
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L. Jayasimman and S. Hendry Leo Kanickam
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Cloud data ,Computer science ,business.industry ,Data_MISCELLANEOUS ,Hash function ,business ,Data Authentication Algorithm ,Computer network - Abstract
Cloud computing is ensuring the security of stored data in cloud computing servers is one of the mainly demanding issues. In Cloud numerous security issues arises such as authentication, integrity and confidentiality. Different encryption techniques attempt to overcome these data security issues to an enormous extent. Hashing algorithm plays an important role in data integrity, message authentication, and digital signature in modern information security. For security purpose using encryption algorithm like ECC (Elliptic Curve Cryptography) and Authentication of data integrity using hashing algorithms like MD5, and SHA-512. This combination method provides data security, authentication and verification for secure cloud computing.
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- 2019
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18. Hidden: A Sister and Brother in Nazi Poland
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Fay Walker, Caren S. Neile, Leo Rosen
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- 2002
19. Diabetic neuropathy: a risk factor for severe COVID-19?
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Linda Tartaglione, Antonio Bianchi, Salvatore Caputo, Dario Pitocco, Mauro A S Di Leo, Luca Viti, Alfredo Pontecorvi, and Angelo Santoliquido
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2019-20 coronavirus outbreak ,medicine.medical_specialty ,Diabetic neuropathy ,Coronavirus disease 2019 (COVID-19) ,business.industry ,severe COVID‑19 ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Endocrinology, Diabetes and Metabolism ,MEDLINE ,Settore MED/13 - ENDOCRINOLOGIA ,General Medicine ,medicine.disease ,Endocrinology ,Diabetes mellitus ,Internal medicine ,medicine ,Internal Medicine ,Risk factor ,business ,Letter to the Editor - Published
- 2021
20. 24. A web platform to incentive sustainable food production and responsible consumption
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S. De Leo and S. Giuca
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Consumption (economics) ,Incentive ,Natural resource economics ,Business ,Sustainable food production - Published
- 2020
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21. SARS-CoV-2 and DPP4 inhibition: Is it time to pray for Janus Bifrons?
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Dario Pitocco, Linda Tartaglione, Alfredo Pontecorvi, Mauro A S Di Leo, Salvatore Caputo, and Luca Viti
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Dipeptidyl Peptidase 4 ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,DPP4 inhibition ,Endocrinology, Diabetes and Metabolism ,Pneumonia, Viral ,030209 endocrinology & metabolism ,Type 2 diabetes ,DPP4 ,medicine.disease_cause ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Downregulation and upregulation ,Diabetes mellitus ,medicine ,Internal Medicine ,Humans ,Hypoglycemic Agents ,DIABETES ,030212 general & internal medicine ,Risk factor ,Pandemics ,Tropism ,Coronavirus ,Dipeptidyl-Peptidase IV Inhibitors ,business.industry ,SARS-CoV-2 ,Settore MED/09 - MEDICINA INTERNA ,COVID-19 ,Settore MED/13 - ENDOCRINOLOGIA ,General Medicine ,medicine.disease ,ACE 2 ,Diabetes Mellitus, Type 2 ,Immunology ,Middle East respiratory syndrome ,Coronavirus Infections ,business ,COVID 19 ,type 1 diabetes mellitus - Abstract
Diabetes could be a risk factor for severity and mortality in patients with coronavirus disease 2019 COVID-19. It has been hypothesized that DPP4 inhibition, a therapy currently available for type 2 diabetes, might represent a target for decreasing the risk of the acute respiratory complications of the COVID-19 infection but (1) lack of demonstration of SARS-CoV2 binding to DPP4 (2) possible protective role of sDPP4 in Middle East respiratory Syndrome (MERS-CoV) (3) demonstrated inhibition and downregulation of DPP4 by HIV1 and MERS-CoV and (4) not exclusive role of the receptor binding in tropism of the Coronavirus family, support that DPP4 inhibition at present doesn't represent a plausible approach to mitigate COVID-19.
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- 2020
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22. Lack of type 1 diabetes involvement in SARS-COV-2 population: Only a particular coincidence?
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Mauro A S Di Leo, Alfredo Pontecorvi, Luca Viti, Linda Tartaglione, Dario Pitocco, Andrea Manto, and Salvatore Caputo
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education.field_of_study ,Type 1 diabetes ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,diabetes ,business.industry ,Endocrinology, Diabetes and Metabolism ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Population ,MEDLINE ,Settore MED/13 - ENDOCRINOLOGIA ,General Medicine ,medicine.disease ,Virology ,Endocrinology ,Diabetes mellitus ,Internal Medicine ,Medicine ,business ,education - Published
- 2020
23. Nature-based solutions for hydro-meteorological risk reduction: a state-of-the-art review of the research area
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Ruangpan, L. Vojinovic, Z. Di Sabatino, S. Sandra Leo, L. Capobianco, V. Oen, A. M. P. McClain, M. E. Lopez-Gunn, E. and Ruangpan, L. Vojinovic, Z. Di Sabatino, S. Sandra Leo, L. Capobianco, V. Oen, A. M. P. McClain, M. E. Lopez-Gunn, E.
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Hydro-meteorological risks due to natural hazards such as severe floods, storm surges, landslides and droughts are causing impacts on different sectors of society. Such risks are expected to become worse given projected changes in climate, degradation of ecosystems, population growth and urbanisation. In this respect, nature-based solutions (NBSs) have emerged as effective means to respond to such challenges. A NBS is a term used for innovative solutions that are based on natural processes and ecosystems to solve different types of societal and environmental challenges. The present paper provides a critical review of the literature concerning NBSs for hydro-meteorological risk reduction and identifies current knowledge gaps and future research prospects. There has been a considerable growth of scientific publications on this topic, with a more significant rise taking place from 2007 onwards. Hence, the review process presented in this paper starts by sourcing 1608 articles from Scopus and 1431 articles from the Web of Science. The full analysis was performed on 146 articles. The analysis confirmed that numerous advancements in the area of NBSs have been achieved to date. These solutions have already proven to be valuable in providing sustainable, cost-effective, multi-purpose and flexible means for hydro-meteorological risk reduction. However, there are still many areas where further research and demonstration are needed in order to promote their upscaling and replication and to make them become mainstream solutions.
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- 2020
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24. AN IMPROVED DATA PROTECTION TECHNIQUE TO SECURE A PUBLIC CLOUD ENVIRONMENT
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S., Hendry Leo Kanickam, primary and Dr., L.Jayasimman, additional
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- 2020
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25. Microsatellite markers reveal low frequency of natural hybridization between the white-footed mouse (Peromyscus leucopus) and deer mouse (Peromyscus maniculatus) in southern Quebec, Canada
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Sarah S. T. Leo and Virginie Millien
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0106 biological sciences ,0301 basic medicine ,Peromyscus ,Genotype ,Rodent ,Zoology ,Biology ,010603 evolutionary biology ,01 natural sciences ,Life history theory ,03 medical and health sciences ,Gene Frequency ,Species Specificity ,biology.animal ,Genetics ,medicine ,Animals ,Polymorphic Microsatellite Marker ,Deer mouse ,medicine.vector_of_disease ,Molecular Biology ,Genotyping ,Geography ,Quebec ,General Medicine ,biology.organism_classification ,030104 developmental biology ,Hybridization, Genetic ,Microsatellite ,Microsatellite Repeats ,Biotechnology - Abstract
In some parts of southern Quebec, two closely related rodent species — the white-footed mouse (Peromyscus leucopus) and the deer mouse (Peromyscus maniculatus) — have recently come in contact because of climate-driven changes in the distribution of the former. Both species share similar morphology, ecology, and life history traits, which suggests that natural hybridization may be possible. Hybridization among these two species can have important implications on the ecological roles these rodents play in disease transmission, yet few researchers have attempted to examine this phenomenon and results from previous hybridization experiments have remained inconclusive and conflicting. In this study, we attempt to investigate the occurrence of hybridization among white-footed mice and deer mice in southern Quebec by genotyping wild caught specimens with selectively neutral, polymorphic microsatellite markers. Our analyses suggest that hybridization may be occurring at extremely low frequency between both species in our study area. The presence of such hybridization events, even at low frequencies, may have implications on disease transmission risk in the region and further detailed studies are necessary.
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- 2017
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26. Notes from the Field: Impact of a Mass Drug Administration Campaign Using a Novel Three-Drug Regimen on Lymphatic Filariasis Antigenemia — American Samoa, 2019
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Lynette Suiaunoa-Scanlan, Marisa Hast, Keri Robinson, Ben Sili, Aifili John Tufa, Kimberly Y. Won, Loretta S. Lees, Emily Dodd, Janet Camacho, Tara A. Brant, Fara Utu, and June S. Vaifanua-Leo
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Male ,medicine.medical_specialty ,Health (social science) ,Epidemiology ,Health, Toxicology and Mutagenesis ,Health Promotion ,Elephantiasis, Filarial ,Health Information Management ,Internal medicine ,medicine ,Prevalence ,Humans ,Mass drug administration ,Child ,Drug regimen ,Lymphatic filariasis ,business.industry ,General Medicine ,medicine.disease ,Health Surveys ,American Samoa ,American samoa ,Child, Preschool ,Mass Drug Administration ,Female ,business ,Notes from the Field ,Program Evaluation - Published
- 2020
27. Experimental evidence of laser power oscillations induced by the relative Fresnel (Goos–Hänchen) phase
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José Augusto Oliveira Huguenin, L. da Silva, S. De Leo, Maurizio Martino, Suely Carvalho, Carvalho, S A, De Leo, S, Huguenin, J A O, Martino, M, and da Silva, L
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Physics ,Physics and Astronomy (miscellaneous) ,business.industry ,Power oscillation ,Phase (waves) ,FOS: Physical sciences ,laser, Goos-Hänchen phase, power oscillation ,Laser ,law.invention ,Optics ,law ,Laser power scaling ,business ,Instrumentation ,Optics (physics.optics) ,Physics - Optics - Abstract
The amplification of the relative Fresnel (Goos-Haenchen) phase by an appropriate number of total internal reflections and the choice of favorable incidence angles allow to observe full oscillations in the power of a DPSS laser transmitted through sequential BK7 blocks. The experimental results confirm the theoretical predictions. The optical apparatus used in this letter can be seen as a new type of two-phase ellipsometric system where the phase of the complex refractive index is replaced by the relative Fresnel (Goos-Haenchen) phase., 7 pages, 3 figures, 1 table
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- 2019
28. Nature-based solutions for hydro-meteorological hazards: Revised concepts, classification schemes and databases
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Debele, S. E. Kumar, P. Sahani, J. Marti-Cardona, B. Mickovski, S. B. Leo, L. S. Porcù, F. Bertini, F. Montesi, D. Vojinovic, Z. Di Sabatino, S. and Debele, S. E. Kumar, P. Sahani, J. Marti-Cardona, B. Mickovski, S. B. Leo, L. S. Porcù, F. Bertini, F. Montesi, D. Vojinovic, Z. Di Sabatino, S.
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Hydro-meteorological hazards (HMHs) have had a strong impact on human societies and ecosystems. Their impact is projected to be exacerbated by future climate scenarios. HMHs cataloguing is an effective tool to evaluate their associated risks and plan appropriate remediation strategies. However, factors linked to HMHs origin and triggers remain uncertain, which pose a challenge for their cataloguing. Focusing on key HMHs (floods, storm surges, landslides, droughts, and heatwaves), the goal of this review paper is to analyse and present a classification scheme, key features, and elements for designing nature-based solutions (NBS) and mitigating the adverse impacts of HMHs in Europe. For this purpose, we systematically examined the literature on NBS classification and assessed the gaps that hinder the widespread uptake of NBS. Furthermore, we critically evaluated the existing literature to give a better understanding of the HMHs drivers and their interrelationship (causing multi-hazards). Further conceptualisation of classification scheme and categories of NBS shows that relatively few studies have been carried out on utilising the broader concepts of NBS in tackling HMHs and that the classification and effectiveness of each NBS are dependent on the location, architecture, typology, green species and environmental conditions, as well as interrelated non-linear systems. NBS are often more cost-effective than hard engineering approaches used within the existing systems, especially when taking into consideration their potential co-benefits. We also evaluated the sources of available data for HMHs and NBS, highlighted gaps in data, and presented strategies to overcome the current shortcomings for the development of the NBS for HMHs. We highlighted specific gaps and barriers that need to be filled since the uptake and upscaling studies of NBS in HMHs reduction is rare. The fundamental concepts and the key technical features of past studies reviewed here could help practitio
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- 2019
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29. Early Feeding Practices in Infants with Phenylketonuria Across Europe
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Karit Reinson, F. Lang, M.E. Dijsselhof, J. Żółkowska, K. Dokoupil, T.A.M. van den Hurk, W. Eberle-Pelloth, Anita MacDonald, Carolyn Dunlop, María A. Ruiz, D. Barrio-Carreras, T. Kozanoğlu, K. Vande Kerckhove, I. Jardim, Andrea Schlune, L. François, J. Wildgoose, C. Correia, A. Re Dionigi, A. De Theux, Bozena Didycz, S. De Leo, A. Skarpalezou, P. Manta-Vogli, K. Straczek, K. Chyż, A. Chrobot, H. Gokmen Ozel, Clara Vasconcelos, Maria Gizewska, Alex Pinto, Karen Corthouts, V. Velez García, M. Jörg-Streller, A. Belanger Quintana, C. Meneses, Barbara Cochrane, M.F. Almeida, K. Schulpis, C. Pedrón-Giner, R. Lilje, A. Grimsley, A.M.J. van Wegberg, T. Winkler, R. Hensler, Júlio César Rocha, G. Bruni, Louise Robertson, K. Plutowska-Hoffmann, M. Bueno-Delgado, N. Koç, Anne Daly, L. Fokkema, R. Pereira, K. Ahring, D. Garcia-Arenas, Andreas Jung, Martine Robert, S.M. Olivas, J. Serrano-Nieto, J. Saligova, S.M. Bernabei, Ulrike Och, E. Forssell, Jetta Tuokkola, R. Thom, I. Liegeois, J. Ekengren, C. Jouault, A. Gutiérrez-Sánchez, K. Lang, Camille Newby, Nur Arslan, U. Meyer, C. Joost, Moira French, C. Bontemps, H. Allen, M. Kanthe, Juri Zuvadelli, E. van Dam, A. Foucart, M. Van Driessche, I.L. Kok, A. De Meyer, J. Drabik, Carmen Rohde, Rachel Skeath, Sharon Evans, An Desloovere, C. Gingell, E.M.C. van der Ploeg, D. Mayr, E. Gyüre, Y. Atik Altınok, B. Kumru, O. Ļubina, A. Slabbert, Stefanie Rosenbaum-Fabian, G. Gugelmo, Claire Nicol, G. Caine, I. Errekalde, A. Liguori, Sandra Adams, A. Rossi, A. Tooke, R. Carvalho, J. Purves, C. Heller, M. Assoun, Carolina Gonçalves, K. Eftring, F. Boyle, A. Terry, S. Mexia, K. van Wyk, Ege Üniversitesi, HUS Children and Adolescents, Clinicum, University of Helsinki, HUS Internal Medicine and Rehabilitation, Children's Hospital, MUMC+: TPZ Dietetiek (9), RS: FHML non-thematic output, and UCL - (SLuc) Unité d'endocrinologie pédiatrique
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0301 basic medicine ,Pediatrics ,PKU, Phenylketonuria ,Breastfeeding ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,IMD, Inherited Metabolic Disorders ,PROTEIN ,030105 genetics & heredity ,Phe-Free Infant Formula ,Endocrinology ,IMD ,Standard infant formula ,HDE PED ,Medicine ,Phenylketonuria ,lcsh:QH301-705.5 ,2. Zero hunger ,lcsh:R5-920 ,1184 Genetics, developmental biology, physiology ,Inherited Metabolic Disorders ,3. Good health ,PKU ,GROWTH ,lcsh:Medicine (General) ,DIETARY-MANAGEMENT ,Research Paper ,Phe ,medicine.medical_specialty ,congenital, hereditary, and neonatal diseases and abnormalities ,Phe, Phenylalanine ,Phenylalanine ,Breast milk ,03 medical and health sciences ,Phe-free infant formula ,Infant practices ,Genetics ,Weaning ,Molecular Biology ,Newborn screening ,Infant Practices ,business.industry ,Dietary management ,nutritional and metabolic diseases ,lcsh:Biology (General) ,Infant formula ,Human medicine ,business ,Breast feeding - Abstract
WOS: 000442229500021, PubMed ID: 30101073, Background: In infants with phenylketonuria (PKU), dietary management is based on lowering and titrating phenylalanine (Phe) intake from breast milk or standard infant formula in combination with a Phe-free infant formula in order to maintain blood Phe levels within target range. Professionals use different methods to feed infants with PKU and our survey aimed to document practices across Europe. Methods: We sent a cross sectional, survey monkey (R) questionnaire to European health professionals working in IMD. It contained 31 open and multiple-choice questions. The results were analysed according to different geographical regions. Results: Ninety-five centres from 21 countries responded. Over 60% of centres commenced diet in infants by age 10 days, with 58% of centres implementing newborn screening by day 3 post birth. At diagnosis, infant hospital admission occurred in 61% of metabolic centres, mainly in Eastern, Western and Southern Europe. Breastfeeding fell sharply following diagnosis with only 30% of women still breast feeding at 6 months. 53% of centres gave pre-measured Phe-free infant formula before each breast feed and 23% alternated breast feeds with Phe-free infant formula. With standard infant formula feeds, measured amounts were followed by Phe-free infant formula to satiety in 37% of centres (n = 35/95), whereas 44% (n = 42/95) advised mixing both formulas together. Weaning commenced between 17 and 26 weeks in 85% centres, >= 26 weeks in 12% and < 17 weeks in 3%. Discussion: This is the largest European survey completed on PKU infant feeding practices. It is evident that practices varied widely across Europe, and the practicalities of infant feeding in PKU received little focus in the PKU European Guidelines (2017). There are few reports comparing different feeding techniques with blood Phe control, Phe fluctuations and growth. Controlled prospective studies are necessary to assess how different infant feeding practices may influence longer term feeding development., Vitaflo, We thank Vitaflo for supporting the publication cost of this paper.
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- 2018
30. Characteristics of a nationwide cohort of patients presenting with isolated hypogonadotropic hypogonadism (IHH)
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Marco Bonomi, Valeria Vezzoli, Csilla Krausz, Fabiana Guizzardi, Silvia Vezzani, Manuela Simoni, Ivan Bassi, Paolo Duminuco, Natascia Di Iorgi, Claudia Giavoli, Alessandro Pizzocaro, Gianni Russo, Mirella Moro, Letizia Fatti, Alberto Ferlin, Laura Mazzanti, Maria Chiara Zatelli, Salvo Cannavò, Andrea M Isidori, Angela Ida Pincelli, Flavia Prodam, Antonio Mancini, Paolo Limone, Maria Laura Tanda, Rossella Gaudino, Mariacarolina Salerno, Pregnolato Francesca, Mohamad Maghnie, Mario Maggi, Luca Persani, G Aimaretti, M Altobelli, M R Ambrosio, M Andrioli, G Angeletti, F Arecco, G Arnaldi, M Arosio, A Balsamo, M Baldassarri, L Bartalena, N Bazzoni, L Beccaria, P Beck-Peccoz, G Bellastella, M Bellizzi, F Benedicenti, S Bernasconi, C Bizzarri, G Bona, S Bonadonna, G Borretta, M Boschetti, A Brunani, V Brunelli, F Buzi, C Cacciatore, B Cangiano, M Cappa, R Casalone, A Cassio, P Cavarzere, V Cherubini, T Ciampani, D Cicognani, A Cignarelli, M Cisternino, P Colombo, S Corbetta, N Corciulo, G Corona, R Cozzi, C Crivellaro, I Dalle Mule, L Danesi, A V D’Elia, E degli Uberti, S De Leo, E Della Valle, M De Marchi, N Di Iorgi, A Di Mambro, A Fabbri, C Foresta, G Forti, A R Franceschi, A Garolla, M Ghezzi, C Giacomozzi, M Giusti, E Grosso, G Guabello, M P Guarneri, G Grugni, A M Isidori, F Lanfranco, A Lania, R Lanzi, L Larizza, A Lenzi, S Loche, P Loli, V Lombardi, M C Maggio, G Mandrile, C Manieri, G Mantovani, S Marelli, M Marzullo, M A Mencarelli, N Migone, G Motta, G Neri, G Padova, G Parenti, B Pasquino, A Pia, E Piantanida, E Pignatti, A Pilotta, B Pivetta, M Pollazzon, A Pontecorvi, P Porcelli, G B Pozzan, G Pozzobon, G Radetti, P Razzore, L Rocchetti, R Roncoroni, G Rossi, E Sala, A Salvatoni, F Salvini, A Secco, M Segni, R Selice, P Sgaramella, F Sileo, A A Sinisi, F Sirchia, A Spada, A Tresoldi, R Vigneri, G Weber, S Zucchini, Bonomi, Marco, Vezzoli, Valeria, Krausz, Csilla, Guizzardi, Fabiana, Vezzani, Silvia, Simoni, Manuela, Bassi, Ivan, Duminuco, Paolo, Di Iorgi, Natascia, Giavoli, Claudia, Pizzocaro, Alessandro, Russo, Gianni, Moro, Mirella, Fatti, Letizia, Ferlin, Alberto, Mazzanti, Laura, Zatelli Maria, Chiara, Cannavò, Salvo, Isidori Andrea, M., Pincelli Angela, Ida, Prodam, Flavia, Mancini, Antonio, Limone, Paolo, Tanda Maria, Laura, Gaudino, Rossella, Salerno, Mariacarolina, Francesca, Pregnolato, Maghnie, Mohamad, Maggi, Mario, Persani, Luca, Italian Network on Central, Hypogonadism., Zatelli, Maria Chiara, Cannavã², Salvo, Isidori, Andrea M., Pincelli, Angela Ida, Tanda, Maria Laura, Aimaretti, G., Altobell, M., Ambrosio, M. R., Andrioli, M., Angelett, G., Arecco, F., Arnald, G., Arosio, M., Balsamo, A., Baldassarr, M., Bartalena, L., Bazzon, N., Beccari, L., Beck-Peccoz, P., Bellastella, G., Bellizz, M., Benedicent, F., Bernasconi, S., Bizzarri, C., Bona, G., Bonadonna, S., Borrett, G., Boschetti, M., Brunani, A., Brunelli, V., Buz, F., Cacciatore, C., Cangiano, B., Cappa, M., Casalone, R., Cassio, A., Cavarzere, P., Cherubini, V., Ciampani, T., Cicognan, D., Cignarell, A., Cisternin, M., Colombo, P., Corbetta, S., Corciul, N., Corona, G., Cozzi, R., Crivellaro, C., Dalle Mule, I., Danesi, L., Eli, A. V. D., Degli Uberti, E., De Leo, S., Della Valle, E., De Marchi, M., Di Iorgi, N., Di Mambr, A., Fabbri, A., Foresta, C., Forti, G., Franceschi, A. R., Garolla, A., Ghezzi, M., Giacomozzi, C., Giusti, M., Grosso, E., Guabello, G., Guarneri, M. P., Grugni, G., Isidori, A. M., Lanfranco, F., Lania, A., Lanzi, R., Larizza, L., Lenzi, A., Loche, S., Loli, P., Lombardi, V., Maggi, M. C., Mandrile, G., Manieri, C., Mantovani, G., Marelli, S., Marzullo, M., Mencarelli, M. A., Migone, N., Motta, G., Neri, G., Padov, G., Parenti, G., Pasquino, B., Pia, A., Piantanida, E., Pignatti, E., Pilotta, A., Pivett, B., Pollazzon, M., Pontecorvi, A., Porcelli, P., Pozza, G. B., Pozzobon, G., Radetti, G., Razzore, P., Rocchett, L., Roncoron, R., Rossi, G., Sala, E., Salvatoni, A., Salvini, F., Secc, A., Segni, M., Selice, R., Sgaramella, P., Sileo, F., Sinisi, A. A., Sirchia, F., Spada, A., Tresoldi, A., Vigneri, R., Weber, G., Zucchini, S., Marco Bonomi, Valeria Vezzoli, Csilla Krausz, Fabiana Guizzardi, Silvia Vezzani, Manuela Simoni, Ivan Bassi, Paolo Duminuco, Natascia Di Iorgi, Claudia Giavoli, Alessandro Pizzocaro, Gianni Russo, Mirella Moro, Letizia Fatti, Alberto Ferlin, Laura Mazzanti, Maria Chiara Zatelli, Salvo Cannavò, Andrea M Isidori, Angela Ida Pincelli, Flavia Prodam, Antonio Mancini, Paolo Limone, Maria Laura Tanda, Rossella Gaudino, Mariacarolina Salerno, Pregnolato Francesca, Mohamad Maghnie, Mario Maggi, Luca Persani, Italian Network on Central Hypogonadism […, A. Cassio, …, S. Zucchini, ], Isidori, Andrea M, Weber, Giovanna, and Italian Network on Central, Hypogonadism
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0301 basic medicine ,Male ,Pediatrics ,Synkinesis ,Kallmann syndrome ,diagnosis ,genotype ,Endocrinology, Diabetes and Metabolism ,Gonadal Steroid Hormone ,Cohort Studies ,Olfaction Disorders ,0302 clinical medicine ,Endocrinology ,Olfaction Disorder ,Young adult ,Age of Onset ,Gonadal Steroid Hormones ,Gonadotropin ,Pituitary Hormone ,Isolated hypogonadotropic hypogonadism ,General Medicine ,isolated hypogonadotropic hypogonadism, pubertal delay ,genetic-basis ,gonadotropin-deficiency ,Diabetes and Metabolism ,Phenotype ,Italy ,Cohort ,Female ,complex ,Cohort study ,Human ,Adult ,medicine.medical_specialty ,Adolescent ,Gonadotropins ,Humans ,Hypogonadism ,Obesity ,Overweight ,Pituitary Hormones ,Young Adult ,030209 endocrinology & metabolism ,NO ,03 medical and health sciences ,Hypogonadotropic hypogonadism ,Adolescent, Adult, Age of Onset, Cohort Studies, Female, Gonadal Steroid Hormones, Gonadotropins, Humans, Hypogonadis, Italy, Male, Obesity, Olfaction Disorders, Overweight, Phenotype, Pituitary Hormones, Synkinesis, Young Adult, Endocrinology, Diabetes and Metabolism, Endocrinology ,Internal medicine ,medicine ,Isolated hypogonadotropic hypogonadism, Kallmann syndrome, Observational cohort study ,gnrh deficiency ,disease ,business.industry ,Settore MED/13 - ENDOCRINOLOGIA ,isolated Hypogonadotropic hypogonadism, kallmann syndrome ,medicine.disease ,body regions ,030104 developmental biology ,Sex steroid ,linked kallmann-syndrome ,heterogeneity ,phenotype ,Observational cohort study ,Synkinesi ,Age of onset ,Cohort Studie ,business - Abstract
Objective Isolated hypogonadotropic hypogonadism (IHH) is a rare disorder with pubertal delay, normal (normoosmic-IHH, nIHH) or defective sense of smell (Kallmann syndrome, KS). Other reproductive and non-reproductive anomalies might be present although information on their frequency are scanty, particularly according to the age of presentation. Design Observational cohort study carried out between January 2008 and June 2016 within a national network of academic or general hospitals. Methods We performed a detailed phenotyping of 503 IHH patients with: (1) manifestations of hypogonadism with low sex steroid hormone and low/normal gonadotropins; (2) absence of expansive hypothalamic/pituitary lesions or multiple pituitary hormone defects. Cohort was divided on IHH onset (PPO, pre-pubertal onset or AO, adult onset) and olfactory function: PPO-nIHH (n = 275), KS (n = 184), AO-nIHH (n = 36) and AO-doIHH (AO-IHH with defective olfaction, n = 8). Results 90% of patients were classified as PPO and 10% as AO. Typical midline and olfactory defects, bimanual synkinesis and familiarity for pubertal delay were also found among the AO-IHH. Mean age at diagnosis was significantly earlier and more frequently associated with congenital hypogonadism stigmata in patients with Kallmann’s syndrome (KS). Synkinesis, renal and male genital tract anomalies were enriched in KS. Overweight/obesity are significantly associated with AO-IHH rather than PPO-IHH. Conclusions Patients with KS are more prone to develop a severe and complex phenotype than nIHH. The presence of typical extra-gonadal defects and familiarity for PPO-IHH among the AO-IHH patients indicates a common predisposition with variable clinical expression. Overall, these findings improve the understanding of IHH and may have a positive impact on the management of patients and their families.
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- 2018
31. A Survey on Layer Wise Issues and Challenges in Cloud Security
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S. Hendry Leo Kanickam, A. Nisha Jebaseeli, and L. Jayasimman
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Engineering ,Service layer ,Cloud computing security ,business.industry ,Software as a service ,Cloud computing ,Network layer ,Computer security ,computer.software_genre ,Software deployment ,Cloud testing ,Layer (object-oriented design) ,business ,computer - Abstract
Cloud Computing heads towards first among the top most developed technologies and with a better panorama in successive years by companies and organizations. This paper deeply analyses the Cloud Computing security hazards in layer wise such as Service layer (IaaS, SaaS, PaaS) network layer, storage layer and deployment models such as Public, Private and Hybrid cloud environments. In this analysis the traditional and approved security solutions were discussed and its procedure evaluating parameters are denoted here. In this paper new proposal for all the cloud layers issues are going to sort out in single package of solution is discussed.
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- 2017
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32. Potential scattering in Dirac field theory
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P. Rotelli, S. De Leo, S., De Leo, and Rotelli, Pietro
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High Energy Physics - Theory ,Physics ,Spinor ,Classical mechanics ,High Energy Physics - Theory (hep-th) ,Physics and Astronomy (miscellaneous) ,Scattering ,FOS: Physical sciences ,Perturbation (astronomy) ,Rectangular potential barrier ,Engineering (miscellaneous) - Abstract
We develop the potential scattering of a spinor within the context of perturbation field theory. As an application, we reproduce, up to second order in the potential, the diffusion results for a potential barrier of quantum mechanics. An immediate consequence is a simple generalization to arbitrary potential forms, a feature not possible in quantum mechanics., Comment: 7 pages
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- 2009
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33. ORIGIN OFDERMACENTOR ALBIPICTUS(ACARI: IXODIDAE) ON ELK IN THE YUKON, CANADA
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Margo J. Pybus, William M. Samuel, Sarah S. T. Leo, and Felix A. H. Sperling
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Ungulate ,Dermacentor albipictus ,Genotype ,Ecology ,biology ,ved/biology ,Range (biology) ,Deer ,ved/biology.organism_classification_rank.species ,Introduced species ,Tick ,biology.organism_classification ,Host Specificity ,Tick Infestations ,Yukon Territory ,parasitic diseases ,Animals ,Acari ,Dermacentor ,Ecology, Evolution, Behavior and Systematics ,Ixodidae ,Microsatellite Repeats - Abstract
Winter ticks (Dermacentor albipictus) on elk (Cervus elaphus canadensis) have recently increased in numbers in the Yukon, Canada, potentially posing risks to other indigenous host species in the region. To evaluate the regional source of winter ticks in the Yukon, we sequenced one nuclear (ITS-2) and two mitochondrial (16SrRNA and COI) genes, and genotyped 14 microsatellite loci from 483 winter tick specimens collected across North America. We analyzed genetic variation across the geographic and host ranges of this tick species with the use of variance partitioning, Bayesian clustering, and standard population genetic analyses. Based on our results, winter ticks on elk in the Yukon could have originated either by translocation from central Alberta or by northward range expansion of more geographically proximate populations in northern Alberta and British Columbia. Although there was some genetic structuring of winter ticks on different hosts in the same region, we found little evidence of host specificity in winter ticks from five ungulate host species, suggesting that the winter ticks on elk in the Yukon could potentially become established on other locally available host species such as moose (Alces alces).
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- 2014
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34. Effect of Andrographolide on in vitro Thrombolytic Activity
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S.K. Afsar, K. Reeta Vija, S. Eugine Leo, and R. Manavalan
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chemistry.chemical_compound ,chemistry ,Andrographolide ,Pharmacology ,In vitro - Published
- 2013
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35. A Petrographic Study of the Anthropomorphic Stelae from the Megalithic Area of Saint-Martin-De-Corléans (Aosta, Northern Italy)
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L. Appolonia, Margherita Serra, V. Rubinetto, Alessandro Borghi, and S. De Leo
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Megalith ,Prehistory ,Petrography ,Archeology ,History ,Provenance ,Outcrop ,Bronze Age ,Chalcolithic ,Ancient history ,Archaeology ,Geology ,Nappe - Abstract
The Megalithic Area of Saint-Martin-de-Corleans (Aosta, northern Italy) consists of anthropomorphic stelae dated to the Copper Age and the beginning of the Early Bronze Age. They were carved in different lithologies of varying provenance according to two successive artistic styles, ‘ancient’ and ‘evolved’. A minero-chemical and a petrographic investigation were carried out on 47 stelae and on reference samples collected from eight different outcrops, aiming to define the provenance of the stone materials. The variety of rocks used for the manufacture of the stelae reflects the geological complexity of the Aosta Valley. Most of the stelae examined were classified as foliated impure marbles, grey banded marbles (‘Bardiglio’), calcschists and metabasites belonging to the Combin Zone (Piedmont Nappe), which outcrops in close proximity to the Megalithic Area. Some stelae of the evolved group consisted of massive marbles with silicate-bearing layers, attributed to the Sion–Courmayeur Zone. Similar stone materials were reported for the stelae of the same age found at the archaeological area of Petit Chasseur (Sion, Switzerland). This is archaeometric confirmation of the archaeological affinity between the stelae occurring at the two prehistoric sites, supporting the hypothesis of cultural exchanges over the Grand St Bernard Pass since the Early Copper Age.
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- 2013
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36. The Genetic Signature of Range Expansion in a Disease Vector-The Black-Legged Tick
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Virginie Millien, Andrew Gonzalez, and Sarah S. T. Leo
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0106 biological sciences ,Genotype ,Range (biology) ,030231 tropical medicine ,Population genetics ,Zoology ,Tick ,Disease Vectors ,010603 evolutionary biology ,01 natural sciences ,Birds ,03 medical and health sciences ,0302 clinical medicine ,Lyme disease ,Spatio-Temporal Analysis ,Genetic variation ,Genetics ,medicine ,Animals ,Molecular Biology ,Genetics (clinical) ,biology ,Ixodes ,Quebec ,Genetic Variation ,bacterial infections and mycoses ,biology.organism_classification ,medicine.disease ,Genetics, Population ,Vector (epidemiology) ,Genetic structure ,Biological dispersal ,Animal Distribution ,Biotechnology ,Microsatellite Repeats - Abstract
Monitoring and predicting the spread of emerging infectious diseases requires that we understand the mechanisms of range expansion by its vectors. Here, we examined spatial and temporal variation of genetic structure among 13 populations of the Lyme disease vector, the black-legged tick, in southern Quebec, where this tick species is currently expanding and Lyme disease is emerging. Our objective was to identify the primary mode of tick movement into Canada based on observed spatial and temporal genetic patterns. Upon genotyping 10 microsatellite loci from 613 tick specimens, we found multiple genetic signatures of frequent long-distance dispersal events, supporting the hypothesis that migratory birds are the primary carriers of black-legged ticks into southern Quebec. When we compared results from analyses of pairwise differences among ticks collected from 8 different sites at different years between 2011 and 2014, we found that genetic variation observed among tick individuals appeared to be better explained by collection year than sampling locality. This suggests that while cohorts of black-legged ticks can rapidly invade large areas across southern Quebec, they also appear to be undergoing frequent turnover. Finally, the amount of genetic variation in tick populations across our study area appeared to be related to their degree of establishment, with established populations displaying a lower amount of temporal genetic variation than adventitious ones. Given that Lyme disease infection risk in a region can be influenced by the relative presence of established and/or adventitious tick populations, our results are useful for understanding both the seasonality and spatial variation of Lyme disease.
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- 2016
37. Multi-taxa integrated landscape genetics for zoonotic infectious diseases: deciphering variables influencing disease emergence
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Andrew Gonzalez, Virginie Millien, and Sarah S. T. Leo
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0106 biological sciences ,0301 basic medicine ,Gene Flow ,Landscape epidemiology ,Population genetics ,Disease ,Biology ,Environment ,010603 evolutionary biology ,01 natural sciences ,Communicable Diseases, Emerging ,Host-Parasite Interactions ,03 medical and health sciences ,Species Specificity ,Zoonoses ,Genetics ,Animals ,Molecular Biology ,Spatial analysis ,Molecular Epidemiology ,Ecology ,Models, Genetic ,Genetic Variation ,General Medicine ,Quantitative genetics ,030104 developmental biology ,Genetics, Population ,Host-Pathogen Interactions ,Geographic Information Systems ,Biological dispersal ,Identification (biology) ,Landscape ecology ,Biotechnology - Abstract
Zoonotic disease transmission systems involve sets of species interacting with each other and their environment. This complexity impedes development of disease monitoring and control programs that require reliable identification of spatial and biotic variables and mechanisms facilitating disease emergence. To overcome this difficulty, we propose a framework that simultaneously examines all species involved in disease emergence by integrating concepts and methods from population genetics, landscape ecology, and spatial statistics. Multi-taxa integrated landscape genetics (MTILG) can reveal how interspecific interactions and landscape variables influence disease emergence patterns. We test the potential of our MTILG-based framework by modelling the emergence of a disease system across multiple species dispersal, interspecific interaction, and landscape scenarios. Our simulations showed that both interspecific-dependent dispersal patterns and landscape characteristics significantly influenced disease spread. Using our framework, we were able to detect statistically similar inter-population genetic differences and highly correlated spatial genetic patterns that imply species-dependent dispersal. Additionally, species that were assigned coupled-dispersal patterns were affected to the same degree by similar landscape variables. This study underlines the importance of an integrated approach to investigating emergence of disease systems. MTILG is a robust approach for such studies and can identify potential avenues for targeted disease management strategies.
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- 2016
38. Characterization of 14 microsatellite loci developed for Dermacentor albipictus and cross-species amplification in D. andersoni and D. variabilis (Acari: Ixodidae)
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Felix A. H. Sperling, Corey S. Davis, and S. S. T. Leo
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Genetics ,Genetic diversity ,Dermacentor albipictus ,ved/biology ,ved/biology.organism_classification_rank.species ,Locus (genetics) ,Biology ,biology.organism_classification ,Loss of heterozygosity ,parasitic diseases ,Microsatellite ,Dermacentor andersoni ,Allele ,Dermacentor variabilis ,Ecology, Evolution, Behavior and Systematics - Abstract
Eleven polymorphic and three monomorphic microsatellite loci were developed for Dermacentor albipictus using three methods: (1) screening of a microsatellite enriched genomic DNA library, (2) in silico screening of EST libraries, and (3) adapting loci previously developed for D. variabilis (Say). An average of 4.91 alleles was detected per polymorphic locus. Average observed and expected heterozygosity among polymorphic loci was 0.518 and 0.623 respectively. No locus was significantly linked and one locus exhibited significant deviation from Hardy–Weinberg equilibrium. All loci amplified with varying success in D. andersoni and D. variabilis. These microsatellite loci will be useful for studying the species boundaries and genetic diversity of Dermacentor albipictus in North America.
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- 2011
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39. Deep Mitochondrial DNA Lineage Divergences Within Alberta Populations of Dermacentor albipictus (Acari: Ixodidae) Do Not Indicate Distinct Species
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Margo J. Pybus, Felix A. H. Sperling, and Sarah S. T. Leo
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Mitochondrial DNA ,Species complex ,Dermacentor albipictus ,General Veterinary ,biology ,ved/biology ,ved/biology.organism_classification_rank.species ,Zoology ,Tick ,biology.organism_classification ,Infectious Diseases ,Insect Science ,parasitic diseases ,Parasitology ,Dermacentor variabilis ,Dermacentor ,Ribosomal DNA ,Ixodidae - Abstract
The winter tick Dermacentor albipictus (Packard) has a single-host life cycle that allows it to reach severe infestation levels on ungulates, particularly moose, Genotypic variation within these and related ticks has been a source of taxonomic confusion, although the continuity in their morphology and life history has generally been interpreted as indicating the existence of a single species, To further investigate this variation, we sequenced regions of two mitochondrial DNA (mtDNA) genes (COI and 16S rDNA), two nuclear genes (lysozyme and ITS-2), and two bacterial markers from Francisella-like endosymbionts found in these ticks (eubacterial mtDNA 16S rRNA and a homolog of Francisella tularensis [Dorofe'ev] 17-kDa lipoprotein). We sampled 42 D. albipictus individuals from whitetail and mule deer culled from three populations in east-central Alberta, as well as four D. albipictus and two Dermacentor variabilis (Say) from other locations, We then compared DNA sequence variation between the genes a...
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- 2010
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40. Cooling Performance of a Combined Solar Thermoelectric−Adsorption Cooling System: An Experimental Study
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Mohammad Omar Abdullah, S. L. Leo, S. H. Tie, K. Abd. Hamid, and J. L. Ngui
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Fuel Technology ,Materials science ,Adsorption ,General Chemical Engineering ,Thermoelectric effect ,Metallurgy ,Water cooling ,Energy Engineering and Power Technology ,Mineralogy - Abstract
A novel solar thermoelectric−adsorption cooling system was built and tested at eight different days. Cooling is produced via the Peltier effect during the day, by means of thermoelectric elements, ...
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- 2009
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41. Description of a new species, Anopheles pseudosundaicus (Diptera: Culicidae) from Kerala, India
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R. Rajendran, K. J. Dhananjeyan, S. C. Tewari, Paramasivan R, J. Hiriyan, S. Victorjerald Leo, P. Philip Samuel, R. Krishnamoorthy, Natarajan Arunachalam, K. Ayanar, and Brij Kishore Tyagi
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Larva ,biology ,Cytochrome oxidase c ,Anopheles ,Holotype ,Zoology ,Dark spot ,biology.organism_classification ,Allotype ,Pupa ,Botany ,Animal Science and Zoology ,Pyretophorus ,Ecology, Evolution, Behavior and Systematics - Abstract
Specimens of Anopheles pseudosundaicus, new species, belonging to the Pyretophorus Series of Anopheles (Cellia), were collected from the coastal areas of Alleppey and Kollam districts in Krerala, southwest India. Female (holotype), male (allotype), pupa and fourth-stage larva of this species are described and illustrated to distinguish it from An. subpictus Grassi and An. sundaicus. (Rodenwaldt). It differs from An. sundaicus by the absence of speckling on legs and from An. subpictus in having a complete prehumeral dark spot on costa in wings. A partial sequence of Cytochrome oxidase C subunit 1 (CO1) of mt DNA places An. pseudosundaicus phylogenetically distant from An. sundaicus and closer to An. subpictus.
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- 2009
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42. A Survey on Layer Wise Issues and Challenges in Cloud Security
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Kanickam, S. Hendry Leo, primary, Jayasimman, L., additional, and Jebaseeli, A. Nisha, additional
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- 2017
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43. Antiviral and Anti-Inflammatory Activities of Fluoxetine in a SARS-CoV-2 Infection Mouse Model
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D. Péricat, S. A. Leon-Icaza, M. Sánchez-Rico, C. Mühle, I. Zoicas, F. Schumacher, R. Planès, R. Mazars, G. Gros, A. Carpinteiro, K. A. Becker, J. Izopet, N. Strub-Wourgaft, P. Sjö, O. Neyrolles, B. Kleuser, F. Limosin, E. Gulbins, J. Kornhuber, E. Meunier, N. Hoertel, and C. Cougoule
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Psychiatry ,RC435-571 - Abstract
Introduction The coronavirus disease 2019 (COVID-19) pandemic continues to cause significant morbidity and mortality worldwide. Since a large portion of the world’s population is currently unvaccinated or incompletely vaccinated and has limited access to approved treatments against COVID-19, there is an urgent need to continue research on treatment options, especially those at low cost and which are immediately available to patients, particularly in low- and middle-income countries. Prior in vitro and observational studies have shown that fluoxetine, possibly through its inhibitory effect on the acid sphingomyelinase/ceramide system, could be a promising antiviral and anti-inflammatory treatment against COVID-19. Objectives The aim of this sudy was to test the potential antiviral and anti-inflammatory activities of fluoxetine against SARS-CoV-2 in a K18-hACE2 mouse model of infection, and against several variants of concern in vitro, and test the hypothesis of the implication of ceramides and/or their derivatives hexosylceramides. Methods We evaluated the potential antiviral and anti-inflammatory activities of fluoxetine in a K18-hACE2 mouse model of SARS-CoV-2 infection, and against variants of concern in vitro, i.e., SARS-CoV-2 ancestral strain, Alpha B.1.1.7, Gamma P1, Delta B1.617 and Omicron BA.5. Results Fluoxetine, administrated after SARS-CoV-2 infection, significantly reduced lung tissue viral titres (Figure 1) and expression of several inflammatory markers (i.e., IL-6, TNFα, CCL2 and CXCL10) (Figure 2). It also inhibited the replication of all variants of concern in vitro. A modulation of the ceramide system in the lung tissues, as reflected by the increase in the ratio HexCer 16:0/Cer 16:0 in fluoxetine-treated mice, may contribute to explain these effects (Figure 3). Image: Image 2: Image 3: Conclusions Our findings demonstrate the antiviral and anti-inflammatory properties of fluoxetine in a K18-hACE2 mouse model of SARS-CoV-2 infection, and its in vitro antiviral activity against variants of concern, establishing fluoxetine as a very promising candidate for the prevention and treatment of SARS-CoV-2 infection and disease pathogenesis. Disclosure of InterestNone Declared
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- 2023
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44. Adjuvant Treatment with Medroxyprogesterone Acetate in Pathological Stage I Endometrial Carcinoma with Myometrial Invasion
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F. Gasparri, C. Bolis, G. Mollica, S. Di Leo, G. De Palo, M. Del Vecchio, E. Saraceno, Patrizia Boracchi, P. Periti, C. Meroni, C. Belloni, Ettore Marubini, P. Marziale, S. Dell’Acqua, C. Orlandi, U.A. Bianchi, G. Cagnazzo, V. Danesino, Costantino Mangioni, A. Onnis, R. Monti, M. Merson, P. Fioretti, G. Pescetto, L. Carenza, M. Vignali, P. Sismondi, and G. Sani
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Oncology ,medicine.medical_specialty ,business.industry ,Internal medicine ,medicine.medical_treatment ,Stage I Endometrial Carcinoma ,medicine ,Medroxyprogesterone acetate ,business ,Pathological ,Adjuvant ,medicine.drug - Published
- 2015
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45. Measurement of the bottom-strange meson mixing phase in the full CDF data set
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Aaltonen, T., Alvarez, González, Amerio, B., Amidei, S., Anastassov, D., Annovi, A., Antos, A., Apollinari, J., Appel, G., J. A., Arisawa, Artikov, T., Asaadi, A., Ashmanskas, J., Auerbach, W., Aurisano, B., Azfar, A., Badgett, F., Bae, W., Barbaro, Galtieri, Barnes, A., V. E., Barnett, B. A., Barria, Bartos, P., Bauce, P., Bedeschi, M., Behari, F., Bellettini, S., Bellinger, G., Benjamin, J., Beretvas, D., Bhatti, A., Bisello, A., Bizjak, D., Bland, I., K. R., Blumenfeld, Bocci, B., Bodek, A., Bortoletto, A., Boudreau, D., Boveia, J., Brigliadori, A., Bromberg, L., Brucken, C., Budagov, E., Budd, J., H. S., Burkett, Busetto, K., Bussey, G., Buzatu, P., Calamba, A., Calancha, A., Camarda, C., Campanelli, S., Campbell, M., Canelli, M., Carls, F., Carlsmith, B., Carosi, D., Carrillo, R., Carron, S., Casal, S., Casarsa, B., Castro, M., Catastini, A., Cauz, P., Cavaliere, D., Cavalli, Sforza, Cerri, M., Cerrito, A., Chen, L., Y. 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K., Sakumoto, Y., Sakurai, L., Santi, K., Sato, V., Saveliev, A., Savoy Navarro, P., Schlabach, A., Schmidt, E. E., Schmidt, T., Schwarz, L., Scodellaro, A., Scribano, F., Scuri, S., Seidel, Y., Seiya, A., Semenov, F., Sforza, S. Z., Shalhout, T., Shear, P. F., Shepard, M., Shimojima, M., Shochet, I., Shreyber Tecker, A., Simonenko, P., Sinervo, K., Sliwa, J. R., Smith, F. D., Snider, A., Soha, V., Sorin, H., Song, P., Squillacioti, M., Stancari, R. S., Deni, B., Stelzer, O., Stelzer Chilton, D., Stentz, J., Strologa, G. L., Strycker, Y., Sudo, A., Sukhanov, I., Suslov, K., Takemasa, Y., Takeuchi, J., Tang, M., Tecchio, P. K., Teng, J., Thom, J., Thome, G. A., Thompson, E., Thomson, D., Toback, S., Tokar, K., Tollefson, T., Tomura, D., Tonelli, S., Torre, D., Torretta, P., Totaro, M., Trovato, F., Ukegawa, S., Uozumi, A., Varganov, F., Vazquez, G., Velev, C., Vellidi, M., Vidal, I., Vila, R., Vilar, J., Vizan, M., Vogel, G., Volpi, P., Wagner, R. L., Wagner, T., Wakisaka, R., Wallny, S. M., Wang, A., Warburton, D., Water, W. C., Wester, D., Whiteson, A. B., Wicklund, E., Wicklund, S., Wilbur, F., Wick, H. H., William, J. S., Wilson, P., Wilson, B. L., Winer, P., Wittich, S., Wolber, H., Wolfe, T., Wright, X., Wu, Z., Wu, K., Yamamoto, D., Yamato, T., Yang, U. K., Yang, Y. C., Yang, W. M., Yao, G. P., Yeh, K., Yi, J., Yoh, K., Yorita, T., Yoshida, G. B., Yu, I., Yu, S. S., Yu, J. C., Yun, A., Zanetti, Y., Zeng, C., Zhou, S., Zucchelli, B. c., Alvarez, A. c., Anastassov, J. c., Anto, J., Appel, T. c., Ct, V., Barne, B., Barnett, P. a., Barria, P. c., Barto, M. a., Bauce, G. a., Bellettini, D. a., Bisello, K., Bland, L. g., Brigliadori, H., Budd, G. a., Busetto, A. b., Cx, F. p., Canelli, S. b., Carrillo, B. b., Casal, A. g., Castro, A. b., Cerri, L. c., Cerrito, Y., Chen, K. c., Ct, W., Chung, Y., Chung, M. a., Ciocci, G. a., Compostella, M., Convery, C., Cox, D., Cox, F. a., Crescioli, J. c., Cueva, N. c., D'Ascenzo, M. a., Dell'Orso, M. a., D'Errico, A. a., Di, J., Dittmann, S. a., Donati, Dorigo, Mirco, N. c., Ershaidat, J., Fernandez, G. c., Flanagan, M., Frank, J., Freeman, J., Garcia, A., Garfinkel, P. a., Garosi, C., Ginsburg, O., González, A., Goshaw, R. b., Group, S., Hahn, J., Han, R., Harr, W. b., Hopkin, R., Hughe, N. b., Cx, M. b., Iori, A. c., Ivanov, E. c., Ct, S., Jun, T., Junk, T. b., C, P., Karchin, Y. c., Kato, D. c., Ct, H. c., Ct, J. c., Ct, M., Kim, S. c., Ct, S., Kim, Y., Kim, Y. c., Ct, A., Kotwal, V. b., Krutelyov, A., Laasanen, R., Lander, K. c., Lannon, G. a., Latino, H. c., Lee, S. c., Lee, S. a., Leo, J., Lewi, A. c., Limosani, C., Lin, D., Litvintsev, D. a., Lucchesi, R. b., Cr, P. a., Maestro, G. b., Manca, M., Martínez, M., Mattson, K., Mcfarland, R. b., Mcnulty, M. b., Mondragon, C. c., Ct, M. a., Morello, M. g., Mussini, J. c., Nachtman, M., Neubauer, J. b., Nielsen, S., Oh, S. a., Pagan, E. b., Palencia, A., Paramonov, G. b., Pauletta, D., Pellett, T., Phillip, S. b., Poprocki, F. c., Prokoshin, F. b., Ptoho, G. a., Punzi, F. g., Rimondi, L. a., Ristori, S. b., Rolli, F. a., Ruffini, W., Sakumoto, L. b., Santi, V. c., Saveliev, A. c., Savoy Navarro, E., Schmidt, A. a., Scribano, F. a., Sforza, S., Shalhout, P., Shepard, M. c., Shimojima, P. b., Cx, J., Smith, F., Snider, P. a., Squillacioti, B. b., Cx, O. b., Cx, D. c., Stentz, G., Strycker, P., Teng, J. b., Thom, G., Thompson, S. c., Tokar, M. a., Trovato, F. b., Vázquez, J., Vizán, R., Wagner, S., Wang, W., Wester, D. b., Whiteson, A., Wicklund, H., William, J., Wilson, B., Winer, P. b., Wittich, U. c., Yang, W., Yao, G., Yeh, K. c., Yi, T. b., Yoshida, G., Yu, I. c., Ct, S., Yu, J., Yun, S. g., Zucchelli, T. Aaltonen, B. Álvarez González, S. Amerio, D. Amidei, A. Anastassov, A. Annovi, J. Anto, G. Apollinari, J. Appel, T. Arisawa, A. Artikov, J. Asaadi, W. Ashmanska, B. Auerbach, A. Aurisano, F. Azfar, W. Badgett, T. Bae, A. Barbaro-Galtieri, V. Barne, B. Barnett, P. Barria, P. Barto, M. Bauce, F. Bedeschi, S. Behari, G. Bellettini, J. Bellinger, D. Benjamin, A. Beretva, A. Bhatti, D. Bisello, I. Bizjak, K. Bland, B. Blumenfeld, A. Bocci, A. Bodek, D. Bortoletto, J. Boudreau, A. Boveia, L. Brigliadori, C. Bromberg, E. Brucken, J. Budagov, H. Budd, K. Burkett, G. Busetto, P. Bussey, A. Buzatu, A. Calamba, C. Calancha, S. Camarda, M. Campanelli, M. Campbell, F. Canelli, B. Carl, D. Carlsmith, R. Carosi, S. Carrillo, S. Carron, B. Casal, M. Casarsa, A. Castro, P. Catastini, D. Cauz, V. Cavaliere, M. Cavalli-Sforza, A. Cerri, L. Cerrito, Y. Chen, M. Chertok, G. Chiarelli, G. Chlachidze, F. Chlebana, K. Cho, D. Chokheli, W. Chung, Y. Chung, M. Ciocci, A. Clark, C. Clarke, G. Compostella, M. Convery, J. Conway, M. Corbo, M. Cordelli, C. Cox, D. Cox, F. Crescioli, J. Cueva, R. Culbertson, D. Dagenhart, N. d’Ascenzo, M. Datta, P. de Barbaro, M. Dell’Orso, L. Demortier, M. Deninno, F. Devoto, M. d’Errico, A. Di Canto, B. Di Ruzza, J. Dittmann, M. D’Onofrio, S. Donati, P. Dong, M. Dorigo, T. Dorigo, K. Ebina, A. Elagin, A. Eppig, R. Erbacher, S. Errede, N. Ershaidat, R. Eusebi, S. Farrington, M. Feindt, J. Fernandez, R. Field, G. Flanagan, R. Forrest, M. Frank, M. Franklin, J. Freeman, Y. Funakoshi, I. Furic, M. Gallinaro, J. Garcia, A. Garfinkel, P. Garosi, H. Gerberich, E. Gerchtein, S. Giagu, V. Giakoumopoulou, P. Giannetti, K. Gibson, C. Ginsburg, N. Giokari, P. Giromini, G. Giurgiu, V. Glagolev, D. Glenzinski, M. Gold, D. Goldin, N. Goldschmidt, A. Golossanov, G. Gomez, G. Gomez-Ceballo, M. Goncharov, O. González, I. Gorelov, A. Goshaw, K. Gouliano, L. Grillo, S. Grinstein, C. Grosso-Pilcher, R. Group, J. Guimaraes da Costa, S. Hahn, E. Halkiadaki, A. Hamaguchi, J. Han, F. Happacher, K. Hara, D. Hare, M. Hare, R. Harr, K. Hatakeyama, C. Hay, M. Heck, J. Heinrich, M. Herndon, S. Hewamanage, A. Hocker, W. Hopkin, D. Horn, S. Hou, R. Hughe, M. Hurwitz, U. Husemann, N. Hussain, M. Hussein, J. Huston, G. Introzzi, M. Iori, A. Ivanov, E. Jame, D. Jang, B. Jayatilaka, E. Jeon, S. Jindariani, M. Jone, K. Joo, S. Jun, T. Junk, T. Kamon, P. Karchin, A. Kasmi, Y. Kato, W. Ketchum, J. Keung, V. Khotilovich, B. Kilminster, D. Kim, H. Kim, J. Kim, M. Kim, S. Kim, Y. Kim, N. Kimura, M. Kirby, S. Klimenko, K. Knoepfel, K. Kondo, D. Kong, J. Konigsberg, A. Kotwal, M. Krep, J. Kroll, D. Krop, M. Kruse, V. Krutelyov, T. Kuhr, M. Kurata, S. Kwang, A. Laasanen, S. Lami, S. Lammel, M. Lancaster, R. Lander, K. Lannon, A. Lath, G. Latino, T. LeCompte, E. Lee, H. Lee, J. Lee, S. Lee, S. Leo, S. Leone, J. Lewi, A. Limosani, C.-J. Lin, M. Lindgren, E. Lipele, A. Lister, D. Litvintsev, C. Liu, H. Liu, Q. Liu, T. Liu, S. Lockwitz, A. Loginov, D. Lucchesi, J. Lueck, P. Lujan, P. Luken, G. Lungu, J. Ly, R. Lysak, R. Madrak, K. Maeshima, P. Maestro, S. Malik, G. Manca, A. Manousakis-Katsikaki, F. Margaroli, C. Marino, M. Martínez, P. Mastrandrea, K. Matera, M. Mattson, A. Mazzacane, P. Mazzanti, K. McFarland, P. McIntyre, R. McNulty, A. Mehta, P. Mehtala, C. Mesropian, T. Miao, D. Mietlicki, A. Mitra, H. Miyake, S. Moed, N. Moggi, M. Mondragon, C. Moon, R. Moore, M. Morello, J. Morlock, P. Movilla Fernandez, A. Mukherjee, Th. Muller, P. Murat, M. Mussini, J. Nachtman, Y. Nagai, J. Naganoma, I. Nakano, A. Napier, J. Nett, C. Neu, M. Neubauer, J. Nielsen, L. Nodulman, S. Noh, O. Norniella, L. Oake, S. Oh, Y. Oh, I. Oksuzian, T. Okusawa, R. Orava, L. Ortolan, S. Pagan Griso, C. Pagliarone, E. Palencia, V. Papadimitriou, A. Paramonov, J. Patrick, G. Pauletta, M. Paulini, C. Pau, D. Pellett, A. Penzo, T. Phillip, G. Piacentino, E. Pianori, J. Pilot, K. Pitt, C. Plager, L. Pondrom, S. Poprocki, K. Potamiano, F. Prokoshin, A. Pranko, F. Ptoho, G. Punzi, A. Rahaman, V. Ramakrishnan, N. Ranjan, I. Redondo, P. Renton, M. Rescigno, T. Riddick, F. Rimondi, L. Ristori, A. Robson, T. Rodrigo, T. Rodriguez, E. Roger, S. Rolli, R. Roser, F. Ruffini, A. Ruiz, J. Ru, V. Rusu, A. Safonov, W. Sakumoto, Y. Sakurai, L. Santi, K. Sato, V. Saveliev, A. Savoy-Navarro, P. Schlabach, A. Schmidt, E. Schmidt, T. Schwarz, L. Scodellaro, A. Scribano, F. Scuri, S. Seidel, Y. Seiya, A. Semenov, F. Sforza, S. Shalhout, T. Shear, P. Shepard, M. Shimojima, M. Shochet, I. Shreyber-Tecker, A. Simonenko, P. Sinervo, K. Sliwa, J. Smith, F. Snider, A. Soha, V. Sorin, H. Song, P. Squillacioti, M. Stancari, R. St. Deni, B. Stelzer, O. Stelzer-Chilton, D. Stentz, J. Strologa, G. Strycker, Y. Sudo, A. Sukhanov, I. Suslov, K. Takemasa, Y. Takeuchi, J. Tang, M. Tecchio, P. Teng, J. Thom, J. Thome, G. Thompson, E. Thomson, D. Toback, S. Tokar, K. Tollefson, T. Tomura, D. Tonelli, S. Torre, D. Torretta, P. Totaro, M. Trovato, F. Ukegawa, S. Uozumi, A. Varganov, F. Vázquez, G. Velev, C. Vellidi, M. Vidal, I. Vila, R. Vilar, J. Vizán, M. Vogel, G. Volpi, P. Wagner, R. Wagner, T. Wakisaka, R. Wallny, S. Wang, A. Warburton, D. Water, W. Wester, D. Whiteson, A. Wicklund, E. Wicklund, S. Wilbur, F. Wick, H. William, J. Wilson, P. Wilson, B. Winer, P. Wittich, S. Wolber, H. Wolfe, T. Wright, X. Wu, Z. Wu, K. Yamamoto, D. Yamato, T. Yang, U. Yang, Y. Yang, W.-M. Yao, G. Yeh, K. Yi, J. Yoh, K. Yorita, T. Yoshida, G. Yu, I. Yu, S. Yu, J. Yun, A. Zanetti, Y. Zeng, C. Zhou, S. Zucchelli, and Universidad de Cantabria
- Subjects
FERMILAB TEVATRON COLLIDER ,Particle physics ,CP-violating asymmetries ,Meson ,B physic ,General Physics and Astronomy ,FOS: Physical sciences ,B physics ,Angle distribution, Branching ratio, CDF experiments, CP violations, CP-violating asymmetries, Data sample, Fermilab Tevatron collider, Integrated luminosity, Longitudinal polarization, Vector meson ,Longitudinal polarization ,7. Clean energy ,01 natural sciences ,High Energy Physics - Experiment ,Vector meson ,Physics and Astronomy (all) ,High Energy Physics - Experiment (hep-ex) ,High Energy Physics - Phenomenology (hep-ph) ,Mixing (mathematics) ,Strange b mesons ,Phase (matter) ,0103 physical sciences ,STRANGE QUARK ,mixing ,Bottom-Strange Meson Mixing Phase ,proton antiproton collisions ,010306 general physics ,TEVATRON ,Nuclear Experiment ,BOTTOM QUARK ,Physics ,Integrated luminosity ,010308 nuclear & particles physics ,Branching ratio ,High Energy Physics - Phenomenology ,CDF experiments ,CP violations ,Full data ,Content (measure theory) ,Angle distribution ,CDF ,Production (computer science) ,High Energy Physics::Experiment ,Data sample - Abstract
We report a measurement of the bottom-strange meson mixing phase βs using the time evolution of Bs0→J/ψ(→μ+μ-)ϕ(→K+K-) decays in which the quark-flavor content of the bottom-strange meson is identified at production. This measurement uses the full data set of proton-antiproton collisions at s=1.96 TeV collected by the Collider Detector experiment at the Fermilab Tevatron, corresponding to 9.6 fb-1 of integrated luminosity. We report confidence regions in the two-dimensional space of βs and the Bs0 decay-width difference ΔΓs and measure βs∈[-π/2,-1.51]∪[-0.06,0.30]∪[1.26,π/2] at the 68% confidence level, in agreement with the standard model expectation. Assuming the standard model value of βs, we also determine ΔΓs=0.068±0.026(stat)±0.009(syst) ps-1 and the mean Bs0 lifetime τs=1.528±0.019(stat)±0.009(syst) ps, which are consistent and competitive with determinations by other experiments., This work was supported by the U.S. Department of Energy and National Science Foundation; the Italian Istituto Nazionale di Fisica Nucleare; the Ministry of Education, Culture, Sports, Science and Technology of Japan; the Natural Sciences and Engineering Research Council of Canada; the National Science Council of the Republic of China; the Swiss National Science Foundation; the A. P. Sloan Foundation; the Bundesministerium für Bildung und Forschung, Germany; the Korean World Class University Program, the National Research Foundation of Korea; the Science and Technology Facilities Council and the Royal Society, UK; the Russian Foundation for Basic Research; the Ministerio de Ciencia e Innovación, and Programa Consolider-Ingenio 2010, Spain; the Slovak R&D Agency; the Academy of Finland; and the Australian Research Council (ARC).
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- 2012
46. Real linear quaternionic differential operators
- Author
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S. De Leo and Gisele Ducati
- Subjects
Constant coefficients ,Pure mathematics ,Differential equation ,Differential operator ,Quantum mechanics ,Quaternionic analysis ,Canonical forms ,Algebra ,Computational Mathematics ,Computational Theory and Mathematics ,Eigenvalue problem ,Modeling and Simulation ,Quaternionic representation ,Modelling and Simulation ,Canonical form ,Quaternions ,Differential operators ,Differential (mathematics) ,Eigenvalues and eigenvectors ,Mathematics - Abstract
The renewed interest in searching for quaternionic deviations of standard (complex) quantum mechanics resulted, in the last years, in a better understanding of the quaternionic mathematical tools needed to solve quantum mechanical problems. In particular, a relevant progress has been achieved in solving eigenvalue problems and differential equations for quaternionic operators. The practical methods recently proposed to solve quaternionic and complex linear second-order differential equations with constant coefficients represent a fundamental starting point to discuss quaternionic potentials in quantum mechanics and study possible violations from complex theories. Nevertheless, only for a restricted class of real linear quaternionic differential operators (namely, symmetric operators) the solution of differential problems was given. In this paper, we study real linear quaternionic differential equations. The proposed resolution's method is based on the Jordan canonical form of (real linear) quaternionic matrices.
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- 2004
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47. Is Taurine Beneficial in Reducing Risk Factors for Diabetes Mellitus?
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Giovanni Ghirlanda, Federico Bennardini, Flavia Franconi, and Mauro A S Di Leo
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medicine.medical_specialty ,Taurine ,medicine.disease_cause ,Biochemistry ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,Insulin resistance ,Risk Factors ,In vivo ,Internal medicine ,Diabetes mellitus ,medicine ,Humans ,Endocrine system ,Neurochemistry ,business.industry ,General Medicine ,medicine.disease ,Glucose ,medicine.anatomical_structure ,Endocrinology ,Diabetes Mellitus, Type 2 ,chemistry ,business ,Pancreas ,Oxidative stress - Abstract
Taurine is a semiessential amino acid, and its deficiency is involved in retinal and cardiac degenerations. In recent years, it was found that diabetes mellitus (DM) is associated with taurine, and many in vivo experimental studies showed that taurine administration is able to reduce the alterations induced by DM in the retina, lens, and peripheral nerve, although its effects on diabetic kidney are dubious. Interestingly, long-term taurine supplementation reduces the mortality rate in diabetic rats. The mechanisms by which taurine exerts beneficial effects in DM are discussed below. Recently, it has been suggested that taurine deficiency may alter the endocrine pancreas "fetal programming," increasing the risk of insulin resistance in adult life. The bulk of experimental data suggests that taurine administration could be useful in the treatment of type 1 DM and in the prevention of insulin resistance.
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- 2004
- Full Text
- View/download PDF
48. Measurement of the cross section for prompt isolated diphoton production in pp̄ collisions at √s=1.96TeV
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T. Aaltonen, B. c. Álvarez, S. Amerio, D. Amidei, A. Anastassov, A. Annovi, J. b. Antos, G. Apollinari, J. Appel, A. Apresyan, T. Arisawa, A. Artikov, J. Asaadi, W. Ashmanskas, B. Auerbach, A. Aurisano, F. Azfar, W. Badgett, A. Barbaro Galtieri, V. Barnes, B. Barnett, P. a. Barria, P. b. Bartos, M. a. Bauce, G. Bauer, F. Bedeschi, D. Beecher, S. Behari, G. a. Bellettini, J. Bellinger, D. Benjamin, A. Beretvas, A. Bhatti, M. Binkley, D. a. Bisello, I. c. Bizjak, K. Bland, B. Blumenfeld, A. Bocci, A. Bodek, D. Bortoletto, J. Boudreau, A. Boveia, B. b. Brau, L. g. Brigliadori, A. b. Brisuda, C. Bromberg, E. Brucken, M. a. Bucciantonio, J. Budagov, H. Budd, S. Budd, K. Burkett, G. a. Busetto, P. Bussey, A. c. cu, C. Calancha, S. Camarda, M. Campanelli, M. Campbell, F. p. bo, A. Canepa, B. Carls, D. Carlsmith, R. Carosi, S. b. Carrillo, S. Carron, B. Casal, M. Casarsa, A. g. Castro, P. Catastini, D. Cauz, V. a. Cavaliere, M. Cavalli Sforza, A. b. Cerri, L. c. Cerrito, Y. Chen, M. Chertok, G. Chiarelli, G. Chlachidze, F. Chlebana, K. c. cp, D. Chokheli, J. Chou, W. Chung, Y. Chung, C. c. Ciobanu, M. a. Ciocci, A. Clark, G. a. Compostella, M. Convery, J. Conway, M. c. Corbo, M. Cordelli, C. Cox, D. Cox, F. a. Crescioli, C. C. Almenar, J. c. Cuevas, R. Culbertson, D. Dagenhart, N. c. cw, M. Datta, P. D. Barbaro, S. D. Cecco, G. D. Lorenzo, M. a. Dell'Orso, C. Deluca, L. Demortier, J. b. Deng, M. Deninno, F. Devoto, M. a. D'Errico, A. a. Di, B. D. Ruzza, J. Dittmann, M. D'Onofrio, S. a. Donati, P. Dong, T. Dorigo, K. Ebina, A. Elagin, A. Eppig, R. Erbacher, D. Errede, S. Errede, R. Eusebi, H. Fang, S. Farrington, M. Feindt, J. Fernandez, C. a. Ferrazza, R. Field, G. c. Flanagan, R. Forrest, M. Frank, M. Franklin, J. Freeman, Y. Funakoshi, I. Furic, M. Gallinaro, J. Galyardt, J. Garcia, A. Garfinkel, P. a. Garosi, H. Gerberich, E. Gerchtein, S. b. Giagu, V. Giakoumopoulou, P. Giannetti, K. Gibson, C. Ginsburg, N. Giokaris, P. Giromini, M. Giunta, G. Giurgiu, V. Glagolev, D. Glenzinski, M. Gold, D. Goldin, N. Goldschmidt, A. Golossanov, G. Gomez, G. Gomez Ceballos, M. Goncharov, O. González, I. Gorelov, A. Goshaw, K. Goulianos, A. Gresele, S. Grinstein, C. Grosso Pilcher, R. Group, J. G. Da, Z. Gunay Unalan, C. Haber, S. Hahn, E. Halkiadakis, A. Hamaguchi, J. Han, F. Happacher, K. Hara, D. Hare, M. Hare, R. Harr, K. Hatakeyama, C. Hays, M. Heck, J. Heinrich, M. Herndon, S. Hewamanage, D. Hidas, A. Hocker, W. b. Hopkins, D. Horn, S. Hou, R. Hughes, M. Hurwitz, U. Husemann, N. c. cu, M. Hussein, J. Huston, G. Introzzi, M. b. Iori, A. c. Ivanov, E. James, D. Jang, B. Jayatilaka, E. c. cp, M. Jha, S. Jindariani, W. Johnson, M. Jones, S. Jun, T. Junk, T. Kamon, P. Karchin, Y. b. Kato, W. Ketchum, J. Keung, V. Khotilovich, B. Kilminster, D. c. cp, H. c. cp, J. c. cp, M. Kim, S. c. cp, S. Kim, Y. Kim, N. Kimura, M. Kirby, S. Klimenko, K. Kondo, J. Konigsberg, A. Kotwal, M. Kreps, J. Kroll, D. Krop, N. c. Krumnack, M. Kruse, V. b. Krutelyov, T. Kuhr, M. Kurata, S. Kwang, A. Laasanen, S. Lami, S. Lammel, M. Lancaster, R. Lander, K. c. Lannon, A. Lath, G. b. Latino, I. Lazzizzera, T. Lecompte, E. Lee, H. Lee, S. c. Lee, S. a. Leo, S. Leone, J. Lewis, C. Lin, J. Linacre, M. Lindgren, E. Lipeles, A. Lister, D. Litvintsev, C. Liu, Q. Liu, T. Liu, S. Lockwitz, N. Lockyer, A. Loginov, D. a. Lucchesi, J. Lueck, P. Lujan, P. Lukens, G. Lungu, J. Lys, R. b. Lysak, R. Madrak, K. Maeshima, K. Makhoul, P. Maksimovic, S. Malik, G. b. Manca, A. Manousakis Katsikakis, F. Margaroli, C. Marino, M. Martínez, R. Martínez Ballarín, P. Mastrandrea, M. Mathis, M. Mattson, P. Mazzanti, K. McFarland, P. McIntyre, R. b. McNulty, A. Mehta, P. Mehtala, A. Menzione, C. Mesropian, T. Miao, D. Mietlicki, A. Mitra, H. Miyake, S. Moed, N. Moggi, M. c. Mondragon, C. c. cp, R. Moore, M. Morello, J. Morlock, P. M. Fernandez, A. Mukherjee, T. Muller, P. Murat, M. g. Mussini, J. c. Nachtman, Y. Nagai, J. Naganoma, I. Nakano, A. Napier, J. Nett, C. Neu, M. Neubauer, J. b. Nielsen, L. Nodulman, O. Norniella, E. Nurse, L. Oakes, S. Oh, Y. c. cp, I. Oksuzian, T. Okusawa, R. Orava, L. Ortolan, S. a. Pagan, C. Pagliarone, E. b. Palencia, V. Papadimitriou, A. Paramonov, J. Patrick, G. b. Pauletta, M. Paulini, C. Paus, D. Pellett, A. Penzo, T. Phillips, G. Piacentino, E. Pianori, J. Pilot, K. Pitts, C. Plager, L. Pondrom, K. Potamianos, O. Poukhov, A. Pranko, F. c. Prokoshin, F. b. Ptohos, E. Pueschel, G. a. Punzi, J. Pursley, A. Rahaman, V. Ramakrishnan, N. Ranjan, I. Redondo, P. Renton, M. Rescigno, F. g. Rimondi, L. a. Ristori, A. Robson, T. Rodrigo, T. Rodriguez, E. Rogers, S. Rolli, R. Roser, M. Rossi, F. Rubbo, F. a. Ruffini, A. Ruiz, J. Russ, V. Rusu, A. Safonov, W. Sakumoto, Y. Sakurai, L. Sartori, K. Sato, V. c. cw, A. c. Savoy Navarro, P. Schlabach, A. Schmidt, E. Schmidt, M. Schmidt, M. Schmitt, T. Schwarz, L. Scodellaro, A. a. Scribano, F. Scuri, A. Sedov, S. Seidel, Y. Seiya, A. Semenov, F. a. Sforza, A. Sfyrla, D. Sgalaberna, S. Shalhout, T. Shears, P. Shepard, M. c. Shimojima, S. Shiraishi, M. Shochet, I. Shreyber, A. Simonenko, P. c. cu, A. Sissakian, K. Sliwa, J. Smith, F. Snider, A. Soha, S. Somalwar, V. Sorin, P. Squillacioti, M. Stancari, M. Stanitzki, R. S. Denis, B. c. cu, O. c. cu, D. Stentz, J. Strologas, G. Strycker, Y. Sudo, A. Sukhanov, I. Suslov, K. Takemasa, Y. Takeuchi, J. Tang, M. Tecchio, P. Teng, J. b. Thom, J. Thome, G. Thompson, E. Thomson, P. Ttito Guzmán, S. Tkaczyk, D. Toback, S. b. Tokar, K. Tollefson, T. Tomura, D. Tonelli, S. Torre, D. Torretta, M. a. Trovato, Y. Tu, F. Ukegawa, A. Varganov, F. b. Vázquez, G. Velev, C. Vellidis, M. Vidal, I. Vila, R. Vilar, J. Vizán, M. Vogel, G. a. Volpi, P. Wagner, R. Wagner, T. Wakisaka, R. Wallny, S. Wang, D. Waters, M. Weinberger, W. Wester, B. Whitehouse, D. b. Whiteson, A. Wicklund, E. Wicklund, S. Wilbur, F. Wick, H. Williams, J. Wilson, P. Wilson, B. Winer, P. b. Wittich, S. Wolbers, H. Wolfe, T. Wright, X. Wu, Z. Wu, K. Yamamoto, J. Yamaoka, T. Yang, U. c. Yang, W. Yao, G. Yeh, K. c. Yi, J. Yoh, K. Yorita, T. b. Yoshida, G. Yu, I. c. cp, S. Yu, J. Yun, Y. Zeng, S. g. Zucchelli, DORIGO, MIRCO, SANTI, LORENZO GIANNI, TOTARO, PIERLUIGI, ZANETTI, ANNA MARIA, T., Aaltonen, B. c., Álvarez, S., Amerio, D., Amidei, A., Anastassov, A., Annovi, J. b., Anto, G., Apollinari, J., Appel, A., Apresyan, T., Arisawa, A., Artikov, J., Asaadi, W., Ashmanska, B., Auerbach, A., Aurisano, F., Azfar, W., Badgett, A., Barbaro Galtieri, V., Barne, B., Barnett, P. a., Barria, P. b., Barto, M. a., Bauce, G., Bauer, F., Bedeschi, D., Beecher, S., Behari, G. a., Bellettini, J., Bellinger, D., Benjamin, A., Beretva, A., Bhatti, M. b., Binkley, D. a., Bisello, I. c., Bizjak, K., Bland, B., Blumenfeld, A., Bocci, A., Bodek, D., Bortoletto, J., Boudreau, A., Boveia, B. b., Brau, L. g., Brigliadori, A. b., Brisuda, C., Bromberg, E., Brucken, M. a., Bucciantonio, J., Budagov, H., Budd, S., Budd, K., Burkett, G. a., Busetto, P., Bussey, A. c., Cw, C., Calancha, S., Camarda, M., Campanelli, M., Campbell, F. p., Canelli, A., Canepa, B., Carl, D., Carlsmith, R., Carosi, S. c., Carrillo, S., Carron, B., Casal, M., Casarsa, A. g., Castro, P., Catastini, D., Cauz, V. a., Cavaliere, M., Cavalli Sforza, A. b., Cerri, L. c., Cerrito, Y., Chen, M., Chertok, G., Chiarelli, G., Chlachidze, F., Chlebana, K. c., Cr, D., Chokheli, J., Chou, W., Chung, Y., Chung, C., Ciobanu, M. a., Ciocci, A., Clark, G. a., Compostella, M., Convery, J., Conway, M., Corbo, M., Cordelli, C., Cox, D., Cox, F. a., Crescioli, C. C., Almenar, J. c., Cueva, R., Culbertson, D., Dagenhart, N. c., D'Ascenzo, M., Datta, P. D., Barbaro, S. D., Cecco, G. D., Lorenzo, M. a., Dell'Orso, C., Deluca, L., Demortier, J. b., Deng, M., Deninno, F., Devoto, M. a., D'Errico, A. a., Di, B. D., Ruzza, J., Dittmann, M., D'Onofrio, S. a., Donati, P., Dong, Dorigo, Mirco, T., Dorigo, K., Ebina, A., Elagin, A., Eppig, R., Erbacher, D., Errede, S., Errede, N. c., Ershaidat, R., Eusebi, H., Fang, S., Farrington, M., Feindt, J., Fernandez, C. a., Ferrazza, R., Field, G. c., Flanagan, R., Forrest, M., Frank, M., Franklin, J., Freeman, Y., Funakoshi, I., Furic, M., Gallinaro, J., Galyardt, J., Garcia, A., Garfinkel, P. a., Garosi, H., Gerberich, E., Gerchtein, S. b., Giagu, V., Giakoumopoulou, P., Giannetti, K., Gibson, C., Ginsburg, N., Giokari, P., Giromini, M., Giunta, G., Giurgiu, V., Glagolev, D., Glenzinski, M., Gold, D., Goldin, N., Goldschmidt, A., Golossanov, G., Gomez, G., Gomez Ceballo, M., Goncharov, O., González, I., Gorelov, A., Goshaw, K., Gouliano, A., Gresele, S., Grinstein, C., Grosso Pilcher, R., Group, J. G., Da, Z., Gunay Unalan, C., Haber, S., Hahn, E., Halkiadaki, A., Hamaguchi, J., Han, F., Happacher, K., Hara, D., Hare, M., Hare, R., Harr, K., Hatakeyama, C., Hay, M., Heck, J., Heinrich, M., Herndon, S., Hewamanage, D., Hida, A., Hocker, W. b., Hopkin, D., Horn, S., Hou, R., Hughe, M., Hurwitz, U., Husemann, N. c., Cw, M., Hussein, J., Huston, G., Introzzi, M. b., Iori, A. c., Ivanov, E., Jame, D., Jang, B., Jayatilaka, E. c., Cr, M., Jha, S., Jindariani, W., Johnson, M., Jone, S., Jun, T., Junk, T., Kamon, P., Karchin, Y. c., Kato, W., Ketchum, J., Keung, V., Khotilovich, B., Kilminster, D. c., Cr, H. c., Cr, J. c., Cr, M., Kim, S. c., Cr, S., Kim, Y., Kim, N., Kimura, M., Kirby, S., Klimenko, K., Kondo, J., Konigsberg, A., Kotwal, M., Krep, J., Kroll, D., Krop, N. c., Krumnack, M., Kruse, V. b., Krutelyov, T., Kuhr, M., Kurata, S., Kwang, A., Laasanen, S., Lami, S., Lammel, M., Lancaster, R., Lander, K. c., Lannon, A., Lath, G. b., Latino, I., Lazzizzera, T., Lecompte, E., Lee, H., Lee, S. c., Lee, S. a., Leo, S., Leone, J., Lewi, C., Lin, J., Linacre, M., Lindgren, E., Lipele, A., Lister, D., Litvintsev, C., Liu, Q., Liu, T., Liu, S., Lockwitz, N., Lockyer, A., Loginov, D. a., Lucchesi, J., Lueck, P., Lujan, P., Luken, G., Lungu, J., Ly, R. b., Lysak, R., Madrak, K., Maeshima, K., Makhoul, P., Maksimovic, S., Malik, G. b., Manca, A., Manousakis Katsikaki, F., Margaroli, C., Marino, M., Martínez, R., Martínez Ballarín, P., Mastrandrea, M., Mathi, M., Mattson, P., Mazzanti, K., Mcfarland, P., Mcintyre, R. b., Mcnulty, A., Mehta, P., Mehtala, A., Menzione, C., Mesropian, T., Miao, D., Mietlicki, A., Mitra, H., Miyake, S., Moed, N., Moggi, M. c., Mondragon, C. c., Cr, R., Moore, M., Morello, J., Morlock, P. M., Fernandez, A., Mukherjee, T., Muller, P., Murat, M. g., Mussini, J. c., Nachtman, Y., Nagai, J., Naganoma, I., Nakano, A., Napier, J., Nett, C., Neu, M., Neubauer, J. b., Nielsen, L., Nodulman, O., Norniella, E., Nurse, L., Oake, S., Oh, Y. c., Cr, I., Oksuzian, T., Okusawa, R., Orava, L., Ortolan, S. a., Pagan, C., Pagliarone, E. b., Palencia, V., Papadimitriou, A., Paramonov, J., Patrick, G. b., Pauletta, M., Paulini, C., Pau, D., Pellett, A., Penzo, T., Phillip, G., Piacentino, E., Pianori, J., Pilot, K., Pitt, C., Plager, L., Pondrom, K., Potamiano, O. b., Poukhov, A., Pranko, F. c., Prokoshin, F. b., Ptoho, E., Pueschel, G. a., Punzi, J., Pursley, A., Rahaman, V., Ramakrishnan, N., Ranjan, I., Redondo, P., Renton, M., Rescigno, F. g., Rimondi, L. a., Ristori, A., Robson, T., Rodrigo, T., Rodriguez, E., Roger, S., Rolli, R., Roser, M., Rossi, F., Rubbo, F. a., Ruffini, A., Ruiz, J., Ru, V., Rusu, A., Safonov, W., Sakumoto, Y., Sakurai, Santi, LORENZO GIANNI, L., Sartori, K., Sato, V. c., Saveliev, A., Savoy Navarro, P., Schlabach, A., Schmidt, E., Schmidt, M. b., Schmidt, M., Schmitt, T., Schwarz, L., Scodellaro, A. a., Scribano, F., Scuri, A., Sedov, S., Seidel, Y., Seiya, A., Semenov, F. a., Sforza, A., Sfyrla, D., Sgalaberna, S., Shalhout, T., Shear, P., Shepard, M. c., Shimojima, S., Shiraishi, M., Shochet, I., Shreyber, A., Simonenko, P. c., Cw, A. b., Sissakian, K., Sliwa, J., Smith, F., Snider, A., Soha, S., Somalwar, V., Sorin, P., Squillacioti, M., Stancari, M., Stanitzki, R. S., Deni, B. c., Cw, O. c., Cw, D., Stentz, J., Strologa, G., Strycker, Y., Sudo, A., Sukhanov, I., Suslov, K., Takemasa, Y., Takeuchi, J., Tang, M., Tecchio, P., Teng, J. b., Thom, J., Thome, G., Thompson, E., Thomson, P., Ttito Guzmán, S., Tkaczyk, D., Toback, S. b., Tokar, K., Tollefson, T., Tomura, D., Tonelli, S., Torre, D., Torretta, Totaro, Pierluigi, M. a., Trovato, Y., Tu, F., Ukegawa, A., Varganov, F. c., Vázquez, G., Velev, C., Vellidi, M., Vidal, I., Vila, R., Vilar, J., Vizán, M., Vogel, G. a., Volpi, P., Wagner, R., Wagner, T., Wakisaka, R., Wallny, S., Wang, D., Water, M., Weinberger, W., Wester, B., Whitehouse, D. b., Whiteson, A., Wicklund, E., Wicklund, S., Wilbur, F., Wick, H., William, J., Wilson, P., Wilson, B., Winer, P. b., Wittich, S., Wolber, H., Wolfe, T., Wright, X., Wu, Z., Wu, K., Yamamoto, J., Yamaoka, T., Yang, U. c., Yang, W., Yao, G., Yeh, K. c., Yi, J., Yoh, K., Yorita, T. b., Yoshida, G., Yu, I. c., Cr, S., Yu, J., Yun, A., Zanetti, Y., Zeng, S. g., Zucchelli, M., Binkley, A. c., Cu, F. p., Bo, S. b., Carrillo, K. c., Cp, C. c., Ciobanu, M. c., Corbo, N. c., Cu, E. c., Cp, Y. b., Kato, D. c., Cp, H. c., Cp, J. c., Cp, S. c., Cp, C. c., Cp, Y. c., Cp, O., Poukhov, V. c., Cw, A. c., Savoy Navarro, M., Schmidt, P. c., Cu, A., Sissakian, B. c., Cu, O. c., Cu, F. b., Vázquez, I. c., Cp, and Zanetti, ANNA MARIA
- Subjects
Photon radiation ,Integrated luminosity ,Photons ,Cross section ,Kinematic variables ,Fermilab Tevatron ,Parton showers ,photons ,High Energy Physics::Phenomenology ,photon ,Cross section, Fermilab Tevatron, Integrated luminosity, Isolated photons, Kinematic variables, Leading orders, Next-to-leading orders, Parton showers, Perturbative QCD, Photon radiation, Total energy ,Leading orders ,Physics and Astronomy (all) ,Tellurium compounds ,Forecasting, Photons ,Total energy ,Forecasting, Photon ,Perturbative QCD ,High Energy Physics::Experiment ,Isolated photons ,Next-to-leading orders ,Forecasting - Abstract
This article reports a measurement of the production cross section of prompt isolated photon pairs in proton-antiproton collisions at √s=1.96TeV using the CDF II detector at the Fermilab Tevatron collider. The data correspond to an integrated luminosity of 5.36fb -1. The cross section is presented as a function of kinematic variables sensitive to the reaction mechanisms. The results are compared with three perturbative QCD calculations: (1) a leading-order parton shower Monte Carlo, (2) a fixed next-to-leading-order calculation and (3) a next-to-leading-order/next-to-next-to-leading-log resummed calculation. The comparisons show that, within their known limitations, all calculations predict the main features of the data, but no calculation adequately describes all aspects of the data. © 2011 American Physical Society.
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- 2011
49. Comprehensive Energy Systems Analysis Support Tools for Decision Making
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S. Loperte, Monica Salvia, S. Di Leo, Vincenzo Cuomo, C. Cosmi, Filomena Pietrapertosa, M. Macchiato, K. Metaxiotis, C., Cosmi, S., Di Leo, S., Loperte, F., Pietrapertosa, M., Salvia, Macchiato, Maria, and V., Cuomo
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Decision Making Support tools ,Comprehensive Energy System Analysis ,Decision support system ,Process management ,Systems analysis ,Decision engineering ,Computer science ,Business decision mapping ,Intelligent decision support system ,Energy (signal processing) ,R-CAST ,Decision analysis - Abstract
Sustainability of energy systems is a common priority that involves key issues such as security of energy supply, mitigation of environmental impacts - the energy sector is currently responsible for 80% of all EU greenhouse gas emissions (European Environment Agency, 2007), contributing heavily to the overall emissions of local air pollutants - and energy affordability. In this framework, energy planning and decision making processes can be supported at different stages and spatial scales (regional, national, pan-European, etc.) by the use of comprehensive models in order to manage the large complexity of energy systems and to define multi-objective strategies on the medium-long term. This Chapter is aimed to outline the value of model-based decision support systems in addressing current challenges aimed to carry out sustainable energy systems and to diffuse the use of strategic energy-environmental planning methods based on the use of partial equilibrium models. The proposed methodology, aimed to derive cost-effective strategies for a sustainable resource management, is based on the experiences gathered in the framework of the IEA-ETSAP program and under several national and international projects.
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- 2011
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50. Potential Therapeutic Effect of Antioxidants in Experimental Diabetic Retina: A Comparison between Chronic Taurine and Vitamin E Plus Selenium Supplementations
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Bruno Giardina, Flavia Franconi, Mauro A S Di Leo, Stefano Angelo Santini, Giovanni Ghirlanda, and Nicolò Gentiloni Silveri
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Blood Glucose ,medicine.medical_specialty ,Taurine ,Time Factors ,Antioxidant ,medicine.medical_treatment ,chemistry.chemical_element ,medicine.disease_cause ,Biochemistry ,Antioxidants ,Diabetes Mellitus, Experimental ,Lipid peroxidation ,Selenium ,chemistry.chemical_compound ,Retinal Diseases ,Diabetes mellitus ,Internal medicine ,medicine ,Animals ,Vitamin E ,business.industry ,Body Weight ,General Medicine ,medicine.disease ,Streptozotocin ,Rats ,Oxidative Stress ,Endocrinology ,chemistry ,Dietary Supplements ,Lipid Peroxidation ,Sodium-Potassium-Exchanging ATPase ,business ,Oxidative stress ,medicine.drug - Abstract
Although good glycaemic control can delay the development and progression of diabetic retinopathy, new therapies are needed to obtain a better control of this diabetic complication. Oxidative stress seems to be a contributing factor in diabetic retinal alterations, therefore, it has been suggested that antioxidants may be beneficial in reducing diabetic retinal changes. However, many questions are still open. In fact, it remains to be ascertained which antioxidants are the most active when they are chronically administered in vivo and their effective dosages. Therefore, we compared the effect of chronic taurine supplementations versus a mixture of vitamin E + selenium on biochemical retinal changes induced by diabetes at different stages of the disease. Briefly, streptozotocin (STZ) diabetic rats were administered for 4 months following the dietary supplements: (a) 2% (w/w) taurine; (b) 5% (w/w) taurine; (c) 200 IU vitamin E + 8 mg selenium/kg diet (d) 500 IU vitamin E + 8 mg selenium/kg diet. In STZ diabetic rat in poor metabolic control (i.e. serum glucose >16.5 mmol/l), at 2, 4, 8, 16 weeks following the onset of diabetes, retinal conjugated dienes (CD) and lipid hydroperoxides (LP) were significantly and progressively increased, while sodium pump activity was gradually and significantly reduced. In taurine and vitamin E + selenium supplemented diabetic rats, glycaemia and body weight were not significantly different from those of non-supplemented diabetic animals. In diabetic rats, 2 and 5% taurine significantly decreased CD. This reduction is long lasting. Regarding CD, both vitamin E + selenium supplementations reduced CD only during the first 4 weeks of diabetes. Two percent taurine supplementation significantly lowered LP for the first 8 weeks of the disease while 5% taurine-induced-reduction lasted for the whole experimental time. A 200 IU vitamin E + 8 mg selenium supplementation did not significantly modify LP, while 500 IU vitamin E + 8 mg selenium significantly lowered them for the whole studied period. Finally, taurine preserved ATPase activity being more effective at 5% than 2%. Two hundred IU vitamin E + 8 mg selenium did not generally modify pump activity, while 500 IU vitamin E + 8 mg selenium partially prevented the decrease in pump activity. We conclude that taurine and vitamin E + selenium supplementations ameliorate biochemical retinal abnormalities caused by diabetes. These effects are dose- and time-dependent Moreover, the effect of taurine on CD is longer lasting than that of vitamin E + selenium. In addition, taurine seems to better preserve ATPase activity in comparison with vitamin E + selenium. Finally, in diabetic animals a negative correlation is found between CD and LP on one side and Na+K+ATPase activity on the other; thus, lipid peroxidation and pump activity seem to be associated. The same inverse correlations are present in vitamin E + selenium supplemented diabetic rats, but are lost in taurine supplemented animals. Therefore, taurine effects may not be simply mediated by its antioxidant activity. Thus, chronical (4 months) taurine and vitamin E + selenium supplementations reduce biochemical retinal alterations in diabetic rat in poor metabolic control.
- Published
- 2003
- Full Text
- View/download PDF
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