471 results on '"S. Valero"'
Search Results
2. Combination of white matter hyperintensities and Aβ burden is related to cognitive composites domain scores in subjective cognitive decline: the FACEHBI cohort
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G. Ortega, A. Espinosa, M. Alegret, GC. Monté-Rubio, O. Sotolongo-Grau, A. Sanabria, JP. Tartari, O. Rodríguez-Gómez, M. Marquié, A. Vivas, M. Gómez-Chiari, E. Alarcón-Martín, A. Pérez-Cordón, N. Roberto, I. Hernández, M. Rosende-Roca, L. Vargas, A. Mauleón, C. Abdelnour, E. Esteban De Antonio, R. López-Cuevas, S. Alonso-Lana, S. Moreno-Grau, I. de Rojas, A. Orellana, L. Montrreal, L. Tárraga, A. Ruiz, M. Boada, S. Valero, and FACEHBI group
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Amyloid-beta (Aß) ,Apolipoprotein E ,Cognitive composites domain scores ,FBB-PET ,Magnetic resonance imaging ,Subjective cognitive decline ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Background To explore whether the combination of white matter hyperintensities (WMHs) and amyloid-beta (Aβ) deposition is associated with worse cognitive performance on cognitive composites (CCs) domain scores in individuals with subjective cognitive decline (SCD). Methods Two hundred participants from the FACEHBI cohort underwent structural magnetic resonance imaging (MRI), 18F-florbetaben positron emission tomography (FBB-PET), and neuropsychological assessment. WMHs were addressed through the Fazekas scale, the Age-Related White Matter Changes (ARWMC) scale, and the FreeSurfer pipeline. Eight CCs domain scores were created using the principal component analysis (PCA). Age, sex, education, and apolipoprotein E (APOE) were used as adjusting variables. Results Adjusted multiple linear regression models showed that FreeSurfer (B − .245; 95% CI − .1.676, − .393, p = .016) and β burden (SUVR) (B − .180; 95% CI − 2.140, − .292; p = .070) were associated with face–name associative memory CCs domain score, although the latest one was not statistically significant after correction for multiple testing (p = .070). There was non-significant interaction of these two factors on this same CCs domain score (p = .54). However, its cumulative effects on face–name associative performance indicated that those individuals with either higher WMH load or higher Aβ burden showed the worst performance on the face–name associative memory CCs domain score. Conclusions Our results suggest that increased WMH load and increased Aβ are independently associated with poorer episodic memory performance in SCD individuals, indicating a cumulative effect of the combination of these two pathological conditions in promoting lower cognitive performance, an aspect that could help in terms of treatment and prevention.
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- 2021
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3. ENDOCARDITIS POR ENTEROCOCO CON RESISTENCIA INTRÍNSECA A VANCOMICINA: A PROPÓSITO DE DOS CASOS
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B. Alcaraz Vidal, R. Mármol Lozano, V. Silva Croizzard, R. Jiménez Sánchez, N. Cobos Trigueros, F. Buendía, M.J. del Amor Espín, T. Dumitru Dumitru, V. Campos Rodríguez, and S. Valero Cifuentes
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Medicine ,Surgery ,RD1-811 - Published
- 2023
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4. ON THE JOINT EXPLOITATION OF OPTICAL AND SAR SATELLITE IMAGERY FOR GRASSLAND MONITORING
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A. Garioud, S. Valero, S. Giordano, and C. Mallet
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Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Applied optics. Photonics ,TA1501-1820 - Abstract
Time series of optical and Synthetic Aperture RADAR (SAR) images provide complementary knowledge about the cover and use of the Earth surface since they exhibit information of distinct physical nature. They have proved to be particularly relevant for monitoring large areas with high temporal dynamics and related to significant ecosystem services. Grasslands are such crucial surfaces, both in terms of economic and environmental issues and the automatic and frequent monitoring of their agricultural practices is required for many purposes. To address this problem, the deep-based SenDVI framework is presented. SenDVI proposes an object-based methodology to estimate NDVI values from Sentinel-1 SAR observations and contextual knowledge (weather, terrain). Values are regressed every 6 days for compliance with monitoring purposes. Very satisfactory results are obtained with this low-level multimodal fusion strategy (R2 = 0.84 on a Sentinel-2 tile). Finer analysis is however required to fully assess the relevance of each modality (Sentinel-1, Sentinel-2, weather, terrain) and feature sets and to propose the simplest conceivable framework. Results show that not all features are necessary and can be discarded while others have a mandatory contribution to the regression task. Moreover, experiments prove that accuracy can be improved by not saturating the network with non-essential information (among contextual knowledge in particular). This allows to move towards more operational solution.
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- 2020
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5. Correlations between plasma and PET beta-amyloid levels in individuals with subjective cognitive decline: the Fundació ACE Healthy Brain Initiative (FACEHBI)
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Itziar de Rojas, J. Romero, O. Rodríguez-Gomez, P. Pesini, A. Sanabria, A. Pérez-Cordon, C. Abdelnour, I. Hernández, M. Rosende-Roca, A. Mauleón, L. Vargas, M. Alegret, A. Espinosa, G. Ortega, S. Gil, M. Guitart, A. Gailhajanet, M. A. Santos-Santos, Sonia Moreno-Grau, O. Sotolongo-Grau, S. Ruiz, L. Montrreal, E. Martín, E. Pelejà, F. Lomeña, F. Campos, A. Vivas, M. Gómez-Chiari, M. A. Tejero, J. Giménez, V. Pérez-Grijalba, G. M. Marquié, G. Monté-Rubio, S. Valero, A. Orellana, L. Tárraga, M. Sarasa, A. Ruiz, M. Boada, and on behalf of the FACEHBI study
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Subjective cognitive decline ,Preclinical AD ,Alzheimer’s disease ,Amyloid β ,Plasma biomarker ,TP42/40 ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Background Peripheral biomarkers that identify individuals at risk of developing Alzheimer’s disease (AD) or predicting high amyloid beta (Aβ) brain burden would be highly valuable. To facilitate clinical trials of disease-modifying therapies, plasma concentrations of Aβ species are good candidates for peripheral AD biomarkers, but studies to date have generated conflicting results. Methods The Fundació ACE Healthy Brain Initiative (FACEHBI) study uses a convenience sample of 200 individuals diagnosed with subjective cognitive decline (SCD) at the Fundació ACE (Barcelona, Spain) who underwent amyloid florbetaben(18F) (FBB) positron emission tomography (PET) brain imaging. Baseline plasma samples from FACEHBI subjects (aged 65.9 ± 7.2 years) were analyzed using the ABtest (Araclon Biotech). This test directly determines the free plasma (FP) and total plasma (TP) levels of Aβ40 and Aβ42 peptides. The association between Aβ40 and Aβ42 plasma levels and FBB-PET global standardized uptake value ratio (SUVR) was determined using correlations and linear regression-based methods. The effect of the APOE genotype on plasma Aβ levels and FBB-PET was also assessed. Finally, various models including different combinations of demographics, genetics, and Aβ plasma levels were constructed using logistic regression and area under the receiver operating characteristic curve (AUROC) analyses to evaluate their ability for discriminating which subjects presented brain amyloidosis. Results FBB-PET global SUVR correlated weakly but significantly with Aβ42/40 plasma ratios. For TP42/40, this observation persisted after controlling for age and APOE ε4 allele carrier status (R 2 = 0.193, p = 1.01E-09). The ROC curve demonstrated that plasma Aβ measurements are not superior to APOE and age in combination in predicting brain amyloidosis. It is noteworthy that using a simple preselection tool (the TP42/40 ratio with an empirical cut-off value of 0.08) optimizes the sensitivity and reduces the number of individuals subjected to Aβ FBB-PET scanners to 52.8%. No significant dependency was observed between APOE genotype and plasma Aβ measurements (p value for interaction = 0.105). Conclusion Brain and plasma Aβ levels are partially correlated in individuals diagnosed with SCD. Aβ plasma measurements, particularly the TP42/40 ratio, could generate a new recruitment strategy independent of the APOE genotype that would improve identification of SCD subjects with brain amyloidosis and reduce the rate of screening failures in preclinical AD studies. Independent replication of these findings is warranted.
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- 2018
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6. Evaluation of the Effectiveness of a Psychoeducational Intervention in Treatment-Naïve Patients with Antidepressant Medication in Primary Care: A Randomized Controlled Trial
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R. Casañas, R. Catalán, R. Penadés, J. Real, S. Valero, MA. Muñoz, LL. Lalucat-Jo, and M. Casas
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Technology ,Medicine ,Science - Abstract
Background. There is evidence supporting the effectiveness of psychoeducation (PE) in patients with symptoms of depression in primary care (PC), but very few studies have assessed this intervention in antidepressant-naïve patients. The aim of this study is to assess the effectiveness of a PE program in these patients, since the use of antidepressant (AD) medication may interfere with the effects of the intervention. Methods. 106 participants were included, 50 from the PE program (12 weekly 1.5-hour sessions) and 56 from the control group (CG) that received the usual care. Patients were assessed at baseline and at 3, 6, and 9 months. The main outcome measures were the Beck Depression Inventory (BDI) and remission based on the BDI. The analysis was carried out on an intention-to-treat basis. Results. The PE program group showed remission of symptoms of 40% (P=0.001) posttreatment and 42% (P=0.012) at 6 months. The analysis only showed significant differences in the BDI score posttreatment (P=0.008; effect size Cohen’s d′=0.55). Conclusions. The PE intervention is an effective treatment in the depressive population not treated with AD medication. Before taking an AD, psychoeducational intervention should be considered.
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- 2015
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7. ENTORNOS SOCIODIGITALES EN TINDER Y SUS REPERCUSIONES EN LA SALUD MENTAL
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Molina-Carmona, Edith, primary, Guevara, Sandra Flores, additional, Canales, Verónica Beatriz Gamboa, additional, Lau, María Guadalupe Curro, additional, Carballido, Elvira Hernández, additional, Ruiz, Gabriela A. González, additional, and Vilchis, Jannet S. Valero, additional
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- 2023
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8. Perfil de la endocarditis infecciosa tratada con dalbavancina en el hospital santa lucía de cartagena
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Vidal, B. Alcaraz, primary, Croizzard, V. Silva, additional, Lozano, R. Mármol, additional, Nicolás, E. Conesa, additional, Sánchez, R. Jiménez, additional, Trigueros, N. Cobos, additional, del Amor Espín, M.J., additional, Dumitru, T. Dumitru, additional, Rodríguez, V. Campos, additional, and Cifuentes, S. Valero, additional
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- 2024
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9. SOCIODIGITAL ENVIRONMENTS IN TINDER AND ITS IMPACT ON MENTAL HEALTH
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Molina-Carmona, Edith, primary, Guevara, Sandra Flores, additional, Canales, Verónica Beatriz Gamboa, additional, Lau, María Guadalupe Curro, additional, Carballido, Elvira Hernández, additional, Ruiz, Gabriela A. González, additional, and Vilchis, Jannet S. Valero, additional
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- 2023
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10. Heteronormatividad
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Rico, Luis Alfonso Guadarrama, primary and Vilchis, Jannet S. Valero, additional
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- 2019
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11. Comment mettre en place une unité periopératoire gériatrique (UPOG) pour les patients opérés d’un cancer urologique
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S. Valero, Y. Moreno, S. Bernardeau, M. Vallée, P. Bouchaert, V. Migeot, and E. Liuu
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Urology - Published
- 2022
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12. Measurement and verification of demand response: the customer load baseline
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A. Gabaldon, A. García-Garre, M.C. Ruiz-Abellón, C. Álvarez-Bel, L.A. Fernandez-Jimenez, J.L. Martnez-Ramos, S. Valero-Verdú, and J. Rodríguez-García
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- 2022
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13. [Conservation of autologous graft of femoral head in bone flap for treatment of acetabular defects]
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V H, Aguirre-Rodríguez, N E, Santa María-Gasca, and F S, Valero-González
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Reoperation ,Bone Transplantation ,Treatment Outcome ,Arthroplasty, Replacement, Hip ,Humans ,Acetabulum ,Femur Head ,Hip Prosthesis ,Prosthesis Failure - Abstract
To describe a bone preservation technique commonly used in neurosurgery in an orthopedic procedure.We describe the case of a patient who undergoes primary hip arthroplasty with an initial unsatisfactory result, the need for a revision with acetabular reconstruction is considered before the wound closure. Keeping the patient's femoral head in soft tissues for second-time reconstruction.After six months of follow-up, complete osseointegration of the femoral head graft was found, with a good clinical and radiological evolution of the patient. Bone conservation techniques in bone flaps have shown good results in the grafts osseointegration in other areas such as neurosurgery.The conservation of bone flaps in subcutaneous tissue for later use as a graft is a viable treatment option also in orthopedic surgery.Describir una técnica de conservación ósea de uso común en neurocirugía en un procedimiento ortopédico.Se describe el caso de una paciente que se somete a artroplastía primaria de cadera con un resultado no satisfactorio inicial, planteándose previo al cierre la necesidad de una revisión con reconstrucción acetabular. Conservando cabeza femoral de paciente en tejidos blandos para realizar reconstrucción en segundo tiempo.Tras seguimiento por seis meses se encuentra completa osteointegración de injerto de cabeza femoral, con buena evolución clínica y radiológica de la paciente. Las técnicas de conservación ósea en colgajos óseos han demostrado buenos resultados en la osteointegración de los injertos en otras áreas como neurocirugía.La conservación de colgajos óseos en tejido celular subcutáneo para posterior uso como injerto es una opción viable de tratamiento también en la cirugía ortopédica.
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- 2022
14. Development and validation of combined symptom-medication scores for allergic rhinitis*
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Sousa-Pinto, B. Azevedo, L.F. Jutel, M. Agache, I. Canonica, G.W. Czarlewski, W. Papadopoulos, N.G. Bergmann, K.-C. Devillier, P. Laune, D. Klimek, L. Anto, A. Anto, J.M. Eklund, P. Almeida, R. Bedbrook, A. Bosnic-Anticevich, S. Brough, H.A. Brussino, L. Cardona, V. Casale, T. Cecchi, L. Charpin, D. Chivato, T. Costa, E.M. Cruz, A.A. Dramburg, S. Durham, S.R. De Feo, G. Gerth van Wijk, R. Fokkens, W.J. Gemicioglu, B. Haahtela, T. Illario, M. Ivancevich, J.C. Kvedariene, V. Kuna, P. Larenas-Linnemann, D.E. Makris, M. Mathieu-Dupas, E. Melén, E. Morais-Almeida, M. Mösges, R. Mullol, J. Nadeau, K.C. Pham-Thi, N. O’Hehir, R. Regateiro, F.S. Reitsma, S. Samolinski, B. Sheikh, A. Stellato, C. Todo-Bom, A. Tomazic, P.V. Toppila-Salmi, S. Valero, A. Valiulis, A. Ventura, M.T. Wallace, D. Waserman, S. Yorgancioglu, A. De Vries, G. van Eerd, M. Zieglmayer, P. Zuberbier, T. Pfaar, O. Almeida Fonseca, J. Bousquet, J.
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Background: Validated combined symptom-medication scores (CSMSs) are needed to investigate the effects of allergic rhinitis treatments. This study aimed to use real-life data from the MASK-air® app to generate and validate hypothesis- and data-driven CSMSs. Methods: We used MASK-air® data to assess the concurrent validity, test-retest reliability and responsiveness of one hypothesis-driven CSMS (modified CSMS: mCSMS), one mixed hypothesis- and data-driven score (mixed score), and several data-driven CSMSs. The latter were generated with MASK-air® data following cluster analysis and regression models or factor analysis. These CSMSs were compared with scales measuring (i) the impact of rhinitis on work productivity (visual analogue scale [VAS] of work of MASK-air®, and Work Productivity and Activity Impairment: Allergy Specific [WPAI-AS]), (ii) quality-of-life (EQ-5D VAS) and (iii) control of allergic diseases (Control of Allergic Rhinitis and Asthma Test [CARAT]). Results: We assessed 317,176 days of MASK-air® use from 17,780 users aged 16-90 years, in 25 countries. The mCSMS and the factor analyses-based CSMSs displayed poorer validity and responsiveness compared to the remaining CSMSs. The latter displayed moderate-to-strong correlations with the tested comparators, high test-retest reliability and moderate-to-large responsiveness. Among data-driven CSMSs, a better performance was observed for cluster analyses-based CSMSs. High accuracy (capacity of discriminating different levels of rhinitis control) was observed for the latter (AUC-ROC = 0.904) and for the mixed CSMS (AUC-ROC = 0.820). Conclusion: The mixed CSMS and the cluster-based CSMSs presented medium-high validity, reliability and accuracy, rendering them as candidates for primary endpoints in future rhinitis trials. © 2022 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
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- 2022
15. [Prevalence of injury of the medial collateral ligament of the knee assessed by magnetic resonance]
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V H, Aguirre-Rodríguez, J F, Valdés-Montor, F S, Valero-González, N E, Santa-María-Gasca, M G, Gómez-Pérez, M C, Sánchez-Silva, C, Zúñiga-Isaac, H E, Pérez-Mora, and G E, Mejía-Terrazas
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Magnetic Resonance Spectroscopy ,Prevalence ,Humans ,Collateral Ligaments ,Magnetic Resonance Imaging ,Retrospective Studies - Abstract
The medial collateral ligament (MCL) is one of the main stabilizers of the knee, but its injury occurs in conjunction with other ligaments.To determine the prevalence of MCL lesions by magnetic resonance imaging, their degrees and associated lesions in our institution.Retrospective study from January to April 2018 where KNEE MRIs were evaluated where the MCL lesion was presented to evaluate the degree and type of associated injuries.We included 368 studies, prevalence of isolated MCL lesion of 3.07%, grade I and grade II, prevalence of concomitant MCL lesions was 17.66% grade I (75%), grade II (15%) and grade III (3%). Associated injuries were medial meniscus injury (46.15%), anterior cruciate ligament injury (30.7%), isolated bone contusion (18.46%), chodral injuries (37.58%), medial vastus injury (14.51%), patellar medial retinacular injury (14.51%), vastus lateral injury (9.23%), posterior cruciate ligament injury (6.15%), lateral meniscus injury (4.61%), iliotibial band tenosynovitis (4.61%), medial facet avulsion fracture (3.07%), Pes Anserine tenosynovitis (3.07%).Prevalence of 17.66% of the MCL injuries in our hospital by magnetic resonance, the first 2 degrees predominate, with a wide spectrum of associated knee injuries.El ligamento colateral medial (LCM) es uno de los principales estabilizadores de la rodilla, pero su lesión se presenta en conjunto con otras lesiones ligamentarias.Determinar la prevalencia de lesiones del LCM por resonancia magnética, sus grados y lesiones asociadas en nuestra institución.Estudio retrospectivo de Enero a Abril de 2018, se evaluaron resonancias magnéticas de rodilla donde se presentó lesión del LCM para evaluar grado y tipo de lesiones asociadas.Se incluyeron 368 estudios, prevalencia de lesión aislada del LCM de 3.07%, una grado I y una grado II, la prevalencia de lesiones de LCM concomitantes fue de 17.66%, grado I (75%), grado II (15%) y grado III (3%). Las lesiones asociadas fueron lesión del menisco medial (46.15%), lesión del ligamento cruzado anterior (30.7%), contusión ósea aislada (18.46%), lesiones condrales (37.58%), lesión de vasto medial (14.51%), lesión del retináculo medial patelar (14.51%), lesión del vasto lateral (9.23%), lesión del ligamento cruzado posterior (6.15%), lesión del menisco lateral (4.61%), tenosinovitis banda iliotibial (4.61%), fractura de avulsión de la faceta medial (3.07%), tenosinovitis de la Pes Anserinus (3.07%).Prevalencia de 17.66% de lesiones del LCM en nuestro hospital por resonancia magnética, predominan los dos primeros grados con un espectro amplio de lesiones asociadas de la rodilla.
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- 2021
16. [Supraspinatus tendon ruptures: correlation between MRI and surgical findings]
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L E, Salinas-Vela, V H, Aguirre-Rodríguez, R B, Palmieri-Bouchan, M I, Encalada-Díaz, G E, Mejía-Terrazas, and F S, Valero-González
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Adult ,Male ,Rupture ,Tendons ,Rotator Cuff ,Humans ,Female ,Middle Aged ,Magnetic Resonance Imaging ,Retrospective Studies ,Rotator Cuff Injuries - Abstract
In rotator cuff rupture, the supraspinatus tendon ranks first in frequency. MRI is the study of choice for preoperative diagnosis and planning. The objective of this study was to assess the concordance between findings observed with MRI and transoperative in patients with supraspinatus tendon rupture.A retrospective analysis was conducted from January 2014 to January 2020. Including patients over the age of 18, with MRI and supraspinatus tendon rupture report. A 2 analysis was performed for sensitivity, specificity, predictive values and diagnostic certainty using surgical findings as a reference. The kappa index was used to show the concordance between MRI and transoperative findings.A total of 79 patients were included in the study, 45 male and 34 female. The average age was 52.14 years. MRI correctly diagnosed 60.76% of supraspinatus ruptures, showing 74% sensitivity and 96% specificity for complete ruptures. For partial ruptures I show a sensitivity of 96%, a specificity of 33%. The kappa index showed a match of 0.90 for total ruptures and 0.53 for partial.MRI demonstrated good sensitivity and specificity for diagnosing complete ruptures, with good match to surgical findings. MRI proved to be a non-specific study for the identification of partial ruptures, which causes these lesions to be overdiagnosed.En la ruptura del manguito de los rotadores, el tendón del supraespinoso ocupa el primer lugar en frecuencia. La resonancia magnética es el estudio de elección para el diagnóstico y planificación preoperatoria. El objetivo de este estudio fue evaluar la concordancia entre los hallazgos observados con la IRM y los hallazgos transoperatorios en pacientes con ruptura del tendón del supraespinoso.Se realizó un análisis retrospectivo de Enero de 2014 a Enero de 2020. Se incluyeron pacientes mayores de 18 años, con IRM y reporte de ruptura del tendón del supraespinoso. Se realizó un análisis de 2 para la sensibilidad, especificidad, valores predictivos y certeza diagnóstica utilizando los hallazgos quirúrgicos como referencia. Se utilizó el índice de Kappa para mostrar la concordancia entre IRM y hallazgos transoperatorios.Un total de 79 pacientes se incluyeron en el estudio, 45 masculinos y 34 femeninos. La edad promedio fue de 52.14 años. La IRM diagnosticó correctamente 60.76% de las rupturas del supraespinoso, mostró una sensibilidad de 74% y especificidad de 96% para rupturas completas. Para rupturas parciales mostró una sensibilidad de 96% y una especificidad de 33%. El índice de Kappa mostró una concordancia de 0.90 para rupturas totales y de 0.53 para rupturas parciales.La resonancia magnética demostró una buena sensibilidad y especificidad para el diagnóstico de rupturas completas, con una buena concordancia con los hallazgos quirúrgicos. La IRM demostró ser un estudio poco específico para la identificación de rupturas parciales, lo cual genera que estas lesiones estén sobrediagnosticadas.
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- 2021
17. [Efficacy of Tranexamic Acid to decrease perioperative bleeding in primary total reverse arthroplasty]
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R B, Palmieri-Bouchan, V H, Aguirre-Rodríguez, L E, Salinas-Vela, M I, Encalada-Díaz, and F S, Valero-González
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Tranexamic Acid ,Blood Loss, Surgical ,Humans ,Blood Transfusion ,Postoperative Hemorrhage ,Arthroplasty, Replacement, Knee ,Antifibrinolytic Agents - Abstract
Reverse shoulder arthroplasty improves function and pain in patients with glenohumeral osteoarthritis and rotator cuff deficiency. However, it is associated with significant blood loss and postoperative hematoma (PO) formation.To determine the efficacy of tranexamic acid (ATXM) to decrease perioperative bleeding in patients undergoing primary reverse shoulder arthroplasty.Cohort of 31 patients undergoing reverse primary arthroplasty, in two groups: group A (17 patients) were given 1 g IV of preoperative tranexamic acid and group B (14 patients) to whom it was not administered. Preoperative hemoglobin and hematocrit were recorded and then after 24 hours of surgery, and quantified bleeding in drainage at 24 hours, as well as blood transfusion needs. The changes presented were statistically compared.Demographic data did not show significant differences between the two groups. There is a tendency to reduce bleeding in surgical drainage in patients with ATXM (115.6 ml vs. 162.65 ml p = 0.0768), in the decrease of hemoglobin (2.16 g/dl vs. 2.79 g/dl p = 0.1257) and hematocrit (6.67% vs. 7.95% p = 0.3431). There was a significant reduction in the use of blood products in patients with ATXM (p = 0.0441).There is a tendency to have less PO bleeding in patients undergoing primary reverse arthroplasty with the use of ATXM and a lower PO blood transfusion requirement.La artroplastía reversa de hombro mejora la función y el dolor en pacientes con artrosis glenohumeral y deficiencia del manguito de los rotadores. Sin embargo, se asocia con pérdida sanguínea significativa y formación de hematoma en el postoperatorio (PO).Determinar la eficacia del ácido tranexámico (ATXM) para disminuir el sangrado perioperatorio en pacientes sometidos a artroplastía reversa primaria de hombro.Cohorte de 31 pacientes sometidos a artroplastía primaria reversa, dos grupos: grupo A (17 pacientes) se les aplicó 1 g intravenoso de ácido tranexámico preoperatorio y el grupo B (14 pacientes) a quienes no se les administró. Se registraron la hemoglobina y el hematocrito preoperatorio y a las 24 horas de la cirugía y el sangrado cuantificado en el drenaje a las 24 horas, así como las necesidades de transfusión sanguínea. Se compararon estadísticamente los cambios presentados.Los datos demográficos no demostraron diferencias significativas entre ambos grupos. Hay tendencia a menor sangrado en el drenaje quirúrgico en los pacientes con ATXM (115.6 vs 162.65 ml, p = 0.0768), en la disminución de hemoglobina (2.16 vs 2.79 g/dl, p = 0.1257) y del hematocrito (6.67% vs 7.95% p = 0.3431). Existió una significativa reducción en el uso de hemoderivados en los pacientes con ATXM (p = 0.0441).Existe una tendencia a presentar menor sangrado PO en pacientes sometidos a artroplastía reversa primaria con el uso del ATXM y un menor requerimiento de transfusión sanguínea PO.
- Published
- 2021
18. [The travelling fellowship experience]
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F S, Valero-González
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Fellowships and Scholarships - Abstract
No Abstract available.
- Published
- 2020
19. [Diagnostic concordance of Magnetic Resonance Imaging of Adhesive Capsulitis, between Imaging Centers and a Shoulder Clinic, with surgical correlation]
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N E, Santa-María-Gasca, V H, Aguirre-Rodríguez, J F, Valdés-Montor, G E, Mejía-Terrazas, and F S, Valero-González
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Shoulder ,Bursitis ,Shoulder Joint ,Humans ,Range of Motion, Articular ,Magnetic Resonance Imaging ,Retrospective Studies - Abstract
Despite the MRI findings present an adequate sensitivity and specificity for the diagnosis of adhesive capsulitis, there is a poor correlation between the imaging results in imaging centers and the diagnosis of a shoulder surgeon and the surgical findings.To evaluate the correlation of the diagnosis of adhesive capsulitis by MRI between imaging centers and the shoulder and elbow surgery service, with subsequent surgical verification.Retrospective, observational and comparative study in 41 patients with adhesive capsulitis diagnosis, the concordance among the MRI reports of different radiology cabinets and the Joint reconstruction clinic was calculated, in 10 cases the diagnosis was corroborated by surgery. The index was determinated between both interpretations and the surgical findings.The concordance among the reports analyzed by the shoulder surgeon of the Joint reconstruction clinic and the cabinets was low, with a index of 0.12, in all the surgical cases the presence of adhesive capsulitis was proved with a index of 0.10 with respect to the cabinets reports.The imaging findings described in the literature are reliable for the diagnosis of adhesive capsulitis. The low concordance with the imaging cabinets leads us to think that it is an underdiagnosed entity.Los hallazgos en resonancia magnética (IRM) presentan una adecuada sensibilidad y especificidad para el diagnóstico de capsulitis adhesiva; sin embargo, existe una baja correlación diagnóstica entre la interpretación realizada en los centros de imagenología y la de la clínica de reconstrucción articular y los hallazgos quirúrgicos.Conocer la correlación del diagnóstico de capsulitis adhesiva por IRM entre centros de imagenología y la clínica de reconstrucción articular con posterior comprobación quirúrgica.Estudio retrospectivo, observacional y comparativo en un grupo de 41 pacientes con diagnóstico de capsulitis adhesiva, comparando la concordancia de los reportes de IRM de distintos centros de imagenología y la clínica de reconstrucción articular, se corroboró quirúrgicamente en 10 casos. Se determinó el índice entre ambas interpretaciones y los hallazgos quirúrgicos.La concordancia de los reportes analizados por el cirujano de hombro de la clínica de reconstrucción articular y los reportes de los centros de imagenología fue baja con un índice de 0.12, en todos los casos quirúrgicos se corroboró la presencia de capsulitis adhesiva, el índice con los reportes de los centros de imagenología fue de 0.10.Los hallazgos en la IRM descritos en la literatura son confiables para el diagnóstico capsulitis adhesiva. La baja concordancia con los centros de imagenología nos orienta a pensar que es una entidad subdiagnosticada por esas instituciones.
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- 2020
20. Velocity bias in intrusive gas-liquid flow measurements
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Hohermuth, B. Kramer, M. Felder, S. Valero, D. and Hohermuth, B. Kramer, M. Felder, S. Valero, D.
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Gas–liquid flows occur in many natural environments such as breaking waves, river rapids and human-made systems, including nuclear reactors and water treatment or conveyance infrastructure. Such two-phase flows are commonly investigated using phase-detection intrusive probes, yielding velocities that are considered to be directly representative of bubble velocities. Using different state-of-the-art instruments and analysis algorithms, we show that bubble–probe interactions lead to an underestimation of the real bubble velocity due to surface tension. To overcome this velocity bias, a correction method is formulated based on a force balance on the bubble. The proposed methodology allows to assess the bubble–probe interaction bias for various types of gas-liquid flows and to recover the undisturbed real bubble velocity. We show that the velocity bias is strong in laboratory scale investigations and therefore may affect the extrapolation of results to full scale. The correction method increases the accuracy of bubble velocity estimations, thereby enabling a deeper understanding of fundamental gas-liquid flow processes.
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- 2021
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21. Prey density determines the faecal-marking behaviour of a solitary predator, the Iberian lynx (Lynx pardinus)
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Mariano R. Recio, Emma S. Valero, Javier Rodríguez-Siles, Emilio Virgós, Rafael Arenas-Rojas, and Tamara Burgos
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0106 biological sciences ,High energy ,Ecology ,05 social sciences ,Endangered species ,Biology ,010603 evolutionary biology ,01 natural sciences ,Predation ,0501 psychology and cognitive sciences ,Animal Science and Zoology ,050102 behavioral science & comparative psychology ,Carnivore ,Predator ,Ecology, Evolution, Behavior and Systematics - Abstract
Scent-marking is a common behaviour among mammals with different functions including territory marking. However, this behaviour has high energy costs and thus a territory owner must select the most...
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- 2018
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22. Exploratory analysis for the implementation of antineoplastic logarithmic dose banding
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Victoria Fornés-Ferrer, S. Valero-García, José Luis Poveda-Andrés, and A. Albert-Marí
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Waiting time ,medicine.medical_specialty ,Time Factors ,Drug Compounding ,Drug Storage ,Dose banding ,Pharmaceutical Science ,Antineoplastic Agents ,Pharmacy ,Workload ,Toxicology ,030226 pharmacology & pharmacy ,Workflow ,03 medical and health sciences ,0302 clinical medicine ,Drug Stability ,Internal medicine ,Antineoplastic agents ,medicine ,Humans ,Pharmacology (medical) ,Quality improvement ,General hospital ,Asepsis ,Retrospective Studies ,Standard preparations ,Pharmacology ,Potential impact ,business.industry ,Outcome measures ,Exploratory analysis ,Compounding ,030220 oncology & carcinogenesis ,Antineoplastic Drugs ,Drug compounding ,Pharmacy Service, Hospital ,business - Abstract
Background Dose banding (DB) is a strategy to rationalise antineoplastic production at Hospital Pharmacy Aseptic Compounding Units (ACUs) and to reduce patient’s waiting time. DB allows for optimizing workflows and workloads, facilitating adoption of new technologies, and increasing safety, quality and efficiency of the compounding process. Objective To evaluate the potential impact of implementation of Logarithmic DB and to identify antineoplastic agents and preparations that fulfil criteria published and establish the number and standard doses that could be compounded in advance at the ACU. Setting University and Polytechnic third level general hospital. Method Retrospective observational study (December 2015–May 2016). Antineoplastic dose production was analysed. Investigational drugs were excluded. Three criteria were applied following bibliography reviewed to select candidates to be compounded at our ACU as standardised using logarithmic DB: (a) Antineoplastic preparations > 250 per year; (b) psychochemical stability in optimal storage conditions at least 14 days; (c) maximum five logarithmic standardised doses that include at least 60% of all individualised doses compounded for a given drug. Main outcome measure Number of antineoplastic agents, preparations and logarithmic standard doses candidates to DB. Results 15,436 antineoplastic individualised doses corresponding to 69 antineoplastic agents were analysed. At our institution applying selection criteria, 19 (27%) antineoplastic drugs (3 monoclonal antibodies, 16 cytotoxic) were potential candidates to DB. 6285 (40%) of compounded individualised dose preparations could be prepared in 84 logarithmic standard doses in advance. Conclusion Dose banding implementations could contribute to rationalise antineoplastic production and increase the ACUs compounding capacity.
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- 2018
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23. Macroeconomic indicators analysis for energy sustainability
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C. Senabre, Carlos Sans, A. Martínez, S. Valero, and E. Velasco
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Renewable Energy, Sustainability and the Environment ,Natural resource economics ,Energy sustainability ,Economics ,Energy Engineering and Power Technology ,Electrical and Electronic Engineering - Published
- 2018
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24. The use of electronic medication order entry system for paediatric conditioning regimens in Spanish hospitals: R1517
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García, S. Valero, Álvarez, P. Marrero, Cava, P. Escobar, Socorro, F. Fuentes, and Fernández Navarro, J. M.
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- 2013
25. Energy efficiency strategies to improve productivity and competitiveness of the EU countries
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C. Senabre, E. Velasco, S. Valero, and A. Martínez
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Renewable Energy, Sustainability and the Environment ,Natural resource economics ,Energy Engineering and Power Technology ,Business ,Electrical and Electronic Engineering ,Eu countries ,Productivity ,Efficient energy use - Published
- 2017
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26. Sustainability as a Paradigm of Energy Policy
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A. Martínez, E. Velasco, C. Senabre, and S. Valero
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Renewable Energy, Sustainability and the Environment ,Sustainability ,Social sustainability ,Economics ,Energy Engineering and Power Technology ,Sustainability organizations ,Electrical and Electronic Engineering ,Environmental economics ,Energy policy - Published
- 2016
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27. ARIA pharmacy 2018 'Allergic rhinitis care pathways for community pharmacy': AIRWAYS ICPs initiative (European Innovation Partnership on Active and Healthy Ageing, DG CONNECT and DG Santé) POLLAR (Impact of Air POLLution on Asthma and Rhinitis) GARD Demonstration project
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Bosnic-Anticevich, S. Costa, E. Menditto, E. Lourenço, O. Novellino, E. Bialek, S. Briedis, V. Buonaiuto, R. Chrystyn, H. Cvetkovski, B. Di Capua, S. Kritikos, V. Mair, A. Orlando, V. Paulino, E. Salimäki, J. Söderlund, R. Tan, R. Williams, D.M. Wroczynski, P. Agache, I. Ansotegui, I.J. Anto, J.M. Bedbrook, A. Bachert, C. Bewick, M. Bindslev-Jensen, C. Brozek, J.L. Canonica, G.W. Cardona, V. Carr, W. Casale, T.B. Chavannes, N.H. Correia de Sousa, J. Cruz, A.A. Czarlewski, W. De Carlo, G. Demoly, P. Devillier, P. Dykewicz, M.S. Gaga, M. El-Gamal, Y. Fonseca, J. Fokkens, W.J. Guzmán, M.A. Haahtela, T. Hellings, P.W. Illario, M. Ivancevich, J.C. Just, J. Kaidashev, I. Khaitov, M. Khaltaev, N. Keil, T. Klimek, L. Kowalski, M.L. Kuna, P. Kvedariene, V. Larenas-Linnemann, D.E. Laune, D. Le, L.T.T. Lodrup Carlsen, K.C. Mahboub, B. Maier, D. Malva, J. Manning, P.J. Morais-Almeida, M. Mösges, R. Mullol, J. Münter, L. Murray, R. Naclerio, R. Namazova-Baranova, L. Nekam, K. Nyembue, T.D. Okubo, K. O'Hehir, R.E. Ohta, K. Okamoto, Y. Onorato, G.L. Palkonen, S. Panzner, P. Papadopoulos, N.G. Park, H.-S. Pawankar, R. Pfaar, O. Phillips, J. Plavec, D. Popov, T.A. Potter, P.C. Prokopakis, E.P. Roller-Wirnsberger, R.E. Rottem, M. Ryan, D. Samolinski, B. Sanchez-Borges, M. Schunemann, H.J. Sheikh, A. Sisul, J.C. Somekh, D. Stellato, C. To, T. Todo-Bom, A.M. Tomazic, P.V. Toppila-Salmi, S. Valero, A. Valiulis, A. Valovirta, E. Ventura, M.T. Wagenmann, M. Wallace, D. Waserman, S. Wickman, M. Yiallouros, P.K. Yorgancioglu, A. Yusuf, O.M. Zar, H.J. Zernotti, M.E. Zhang, L. Zidarn, M. Zuberbier, T. Bousquet, J.
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humanities - Abstract
Pharmacists are trusted health care professionals. Many patients use over-the-counter (OTC) medications and are seen by pharmacists who are the initial point of contact for allergic rhinitis management in most countries. The role of pharmacists in integrated care pathways (ICPs) for allergic diseases is important. This paper builds on existing studies and provides tools intended to help pharmacists provide optimal advice/interventions/strategies to patients with rhinitis. The Allergic Rhinitis and its Impact on Asthma (ARIA)-pharmacy ICP includes a diagnostic questionnaire specifically focusing attention on key symptoms and markers of the disease, a systematic Diagnosis Guide (including differential diagnoses), and a simple flowchart with proposed treatment for rhinitis and asthma multimorbidity. Key prompts for referral within the ICP are included. The use of technology is critical to enhance the management of allergic rhinitis. However, the ARIA-pharmacy ICP should be adapted to local healthcare environments/situations as regional (national) differences exist in pharmacy care. © 2018 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
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- 2019
28. Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks : The GR@ACE project
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Jordi Clarimón, G. Monté-Rubio, Miguel A. Santos-Santos, L. Vargas, E. Pelejà, M.T. Martínez, E. Alarcón-Martín, A. Mauleón, P. Martínez-Lage Álvarez, A. Carracedo, N. Aguilera, Goo Amer-Ferrer, M.J. Bullido, Pascual Sánchez-Juan, Olalla Maroñas, J.A. Pineda, Carmen Martínez, Carmen Lage, Antonio González-Pérez, V. Martínez, Angel Carracedo, Susana Ruiz, A. López de Munáin, E. L. Martin, O. Maroñas, Manuel Menéndez-González, Begoña Hernández-Olasagarre, Luis Miguel Real, S. Ruiz, Marta Marquié, Pablo Mir, Montse Alegret, María J. Bullido, Pilar Gómez-Garre, A. Sanabria, Carla Abdelnour, Silvia Jesús, M.M. de Pancorbo, J. Clarimón, Agustín Ruiz, M. Boada, José María García-Alberca, J.M. Cruz-Gamero, Ignacio Alvarez, P. Mir, Adelina Orellana, Alberto Rábano, J.L. Royo, Alberto Lleó, M.J. Casajeros, O. Sotolongo-Grau, R. Sanchez del Valle Díaz, Ana Espinosa, Nuria Aguilera, G. Piñol Ripoll, J. Pérez Tur, S. Manzanares, M. Marquié, Miguel Medina, S. Rodrigo, Teresa Periñán-Tocino, A. Rábano, A. Martín Montes, A. Gailhajenet, Daniel Macias, Ana Mauleón, E. Franco, Miguel Calero, Adela Orellana, P. Cañabate, M. Rosende-Roca, Jose Luis Royo, Gemma Ortega, M. Moreno, Juan A. Pineda, Marina Guitart, Marta Ibarria, A. Benaque, Maria Eugenia Sáez, Manuel Serrano-Ríos, A. Ruiz, Carmen Antúnez, Mariola Moreno, Juan Macías, Pilar Cañabate, L.M. Real, A. Lafuente, Astrid Adarmes-Gómez, Fátima Carrillo, A. Espinosa, T. Marín, S. Preckler, T. del Ser, Eloy Rodríguez-Rodríguez, S. Moreno-Grau, Susana Diego, Gemma Monté-Rubio, L. Montrreal, Rafael Blesa, Mercè Boada, M.P. Vicente, Asunción Lafuente, Emilio Franco, B. Martínez, Laura Montrreal, Itziar de Rojas, I. Hernández, Mario Carrión-Claro, Alba Benaque, I. de Rojas, Emilio Alarcón-Martín, Jesús Avila, S. Garcia Madrona, S. Valero, D. Real de Asúa, L. Vivancos, Ana Frank-García, J.A. Burguera, Liliana Vargas, Labrador Espinosa, Sara López-García, Angela Sanabria, Ana Pancho, A.B. Pastor, Juan Fortea, A. Legaz, Oscar Sotolongo-Grau, Laura Madrid, Sonia Moreno-Grau, J. Marín-Muñoz, M. Calero, Emilio Alarcón, Lluís Tárraga, M. Marín, Miquel Baquero, Sergi Valero, Mar Buendía, José-Luis Molinuevo, M. Mendioroz Iriarte, Alba Pérez-Cordón, C. Abdelnour, V. Álvarez, Pau Pastor, Silvia Gil, J.M. García-Alberca, A. González Pérez, A. Pérez-Cordon, Maitée Rosende-Roca, O. Rodríguez-Gómez, Victoria Alvarez, Isabel Sastre, Inés Quintela, Guillermo García-Ribas, Isabel Hernández, Octavio Rodriguez-Gomez, Arturo Corbatón, G. Ortega, C. Antúnez, P. García González, Monica Diez-Fairen, P. Pastor, P. Sánchez-Juan, L. Tárraga, G. Garcia-Ribas, Montserrat Alegret, S. Hevilla, Maria Jose Bernal, María Eugenia Sáez, M. Medina, I. Quintela, Silvia Preckler, M. Antequera, Dolores Buiza-Rueda, M.A. Santos-Santos, Gerard Piñol-Ripoll, S. Gil, European Commission, Universidad de Cantabria, Fundación La Caixa, Grifols (Spain), Fundació ACE, Instituto de Salud Carlos III, Ministerio de Sanidad (España), Unión Europea, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Regional Government of Andalusia (España), National Institutes of Health (Estados Unidos), United States Department of Defense, NIH - National Institute on Aging (NIA) (Estados Unidos), NIH - National Institute of Biomedical Imaging and Bioengineering (NIBIB) (Estados Unidos), Innovative Medicines Initiative, Unión Europea. Comisión Europea. 6 Programa Marco, Alzheimer's Disease Genetics Consortium, GRIFOLS, European Union, European Regional Development Fund (ERDF/FEDER), Gobierno de Andalucía, National Institutes of Health (United States), Department of Defense USA, National Institute on Aging, National Institute of Biomedical Imaging and Bioengineering, and 6º Programa Marco - Comisión Europea
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0301 basic medicine ,Male ,Epidemiology ,humanos ,vascular pathology ,enfermedad de Alzheimer ,Genome-wide association study ,Disease ,demencia ,0302 clinical medicine ,sitios genéticos ,GWAS ,Cerebrovascular disease ,mediana edad ,anciano ,Health Policy ,gwas ,Alzheimer's disease ,Middle Aged ,rare ,Causality ,3. Good health ,Psychiatry and Mental health ,Biological Pathway ,alzheimer's disease ,Female ,Cerebral amyloid angiopathy ,Malalties cerebrovasculars ,biological pathway ,metaanalysis ,Endophenotypes ,onset ,Vascular Pathology ,Computational biology ,Biology ,Polymorphism, Single Nucleotide ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Alzheimer Disease ,medicine ,Dementia ,Humans ,Genetic Predisposition to Disease ,Alzheimer’s Disease ,endofenotipos ,gene ,Gene ,cerebral amyloid angiopathy ,cognitive function ,Aged ,Mechanism (biology) ,predisposición genética a la enfermedad ,medicine.disease ,mutations ,immunity ,Cerebral Amyloid Angiopathy ,030104 developmental biology ,Malaltia d'Alzheimer ,Spain ,Genetic Loci ,Endophenotype ,estudio de asociación genómica completa ,Neurology (clinical) ,vascular risk ,Geriatrics and Gerontology ,030217 neurology & neurosurgery ,Genome-Wide Association Study - Abstract
Introduction: Large variability among Alzheimer's disease (AD) cases might impact genetic discoveries and complicate dissection of underlying biological pathways. Methods: Genome Research at Fundacio ACE (GR@ACE) is a genome-wide study of dementia and its clinical endophenotypes, defined based on AD's clinical certainty and vascular burden. We assessed the impact of known AD loci across endophenotypes to generate loci categories. We incorporated gene coexpression data and conducted pathway analysis per category. Finally, to evaluate the effect of heterogeneity in genetic studies, GR@ACE series were meta-analyzed with additional genome-wide association study data sets. Results: We classified known AD loci into three categories, which might reflect the disease clinical heterogeneity. Vascular processes were only detected as a causal mechanism in probable AD. The meta-analysis strategy revealed the ANKRD31-rs4704171 and NDUFAF6-rs10098778 and confirmed SCIMP-rs7225151 and CD33-rs3865444. Discussion: The regulation of vasculature is a prominent causal component of probable AD. GR@ACE meta-analysis revealed novel AD genetic signals, strongly driven by the presence of clinical heterogeneity in the AD series., The authors would like to thank patients and controls who participated in this project. The Genome Research @ Fundacio ACE project (GR@ACE) is supported by Fundacion bancaria La Caixa, Grifols SA, Fundacio ACE, and ISCIII (Ministry of Health, Spain). They also want to thank the private sponsors who support the basic and clinical projects of our institution (Piramal AG, Laboratorios Echevarne, Araclon Biotech S.A., and Fundacio ACE). They are indebted to the Trinitat Port-Carbo legacy and her family for their support of Fundacio ACE research programs. Fundacio ACE is a participating center in the Dementia Genetics Spanish Consortium (DEGESCO). A.R. and M.B. receive support from the European Union/EFPIA Innovative Medicines Initiative Joint undertaking ADAPTED and MOPEAD projects (grant numbers 115975 and 115985, respectively). M.B. and A.R. are also supported by national grants PI13/02434, PI16/01861, and PI17/01474. Accion Estrategica en Salud is integrated into the Spanish National R + D + I Plan and funded by ISCIII (Instituto de Salud Carlos III)-Subdireccion General de Evaluacion and the Fondo Europeo de Desarrollo Regional (FEDER-Una manera de Hacer Europa). L.M.R. is supported by Consejeria de Salud de la Junta de Andalucia (grant PI-0001/2017). Control samples and data from patients included in this study were provided in part by the National DNA Bank Carlos III (www.bancoadn.org, University of Salamanca, Spain) and Hospital Universitario Virgen de Valme (Sevilla, Spain); they were processed after standard operating procedures with the appropriate approval of the Ethical and Scientific Committee. The present work was performed as part of the Biochemistry, Molecular Biology, and Biomedicine doctoral program of S. MorenoGrau at Universitat Autonoma de Barcelona (Barcelona, Spain).r Data collection and sharing for this project was partially funded by the Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health grant U01 AG024904) and DOD ADNI (Department of Defense award number W81XWH-12-2-0012). The ADNI is funded by the National Institute on Aging and the National Institute of Biomedical Imaging and Bioengineering, as well as through generous contributions from the following: AbbVie; the Alzheimer's Association; the Alzheimer's Drug Discovery Foundation; Araclon Biotech; BioClinica, Inc.; Biogen; Bristol-Myers Squibb Company; CereSpir, Inc.; Cogstate; Eisai Inc.; Elan Pharmaceuticals, Inc.; Eli Lilly and Company; EuroImmun; F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc.; Fujirebio; GE Healthcare; IXICO Ltd.; Janssen Alzheimer Immunotherapy Research & Development, LLC.; Johnson & Johnson Pharmaceutical Research & Development LLC.; Lumosity; Lundbeck; Merck & Co., Inc.; Meso Scale Diagnostics, LLC.; NeuroRx Research; Neurotrack Technologies; Novartis Pharmaceuticals Corporation; Pfizer Inc.; Piramal Imaging; Servier; Takeda Pharmaceutical Company; and Transition Therapeutics. The Canadian Institutes of Health Research provides funds to support ADNI clinical sites in Canada. Private sector contributions are facilitated by the Foundation for the National Institutes of Health (www.fnih.org). The grantee organization is the Northern California Institute for Research and Education, and the study was coordinated by the Alzheimer's Therapeutic Research Institute at the University of Southern California. ADNI data are disseminated by the Laboratory for NeuroImaging at the University of Southern California.; r The AddNeuroMed data are from a public-private partnership supported by EFPIA companies and SMEs as part of InnoMed (Innovative Medicines in Europe), an integrated project funded by the European Union of the Sixth Framework program priority FP6-2004-LIFESCIHEALTH-5. Clinical leads responsible for data collection are Iwona K1oszewska (Lodz), Simon Lovestone (London), Patrizia Mecocci (Perugia), Hilkka Soininen (Kuopio), Magda Tsolaki (Thessaloniki), and Bruno Vellas (Toulouse). Imaging leads are Andy Simmons (London), Lars-Olad Wahlund (Stockholm), and Christian Spenger (Zurich). Bioinformatics leads are Richard Dobson (London) and Stephen Newhouse (London).r Funding support for the Alzheimer's Disease Genetics Consortium (ADGC) was provided through the NIA Division of Neuroscience (U01-AG032984).r The Mayo Clinic Alzheimer's Disease Genetic Studies, led by Dr. Nilufer Ertekin-Taner and Dr. Steven G. Younkin at the Mayo Clinic in Jacksonville, FL, used samples from the Mayo Clinic Study of Aging, the Mayo Clinic Alzheimer's Disease Research Center, and the Mayo Clinic Brain Bank. Data collection was supported through funding by NIA grants P50 AG016574, R01 AG032990, U01 AG046139, R01 AG018023, U01 AG006576, U01 AG006786, R01 AG025711, R01 AG017216, and R01 AG003949, NINDS grant R01 NS080820, the CurePSP Foundation, and support from the Mayo Foundation.r The Neocodex-Murcia study was funded by the Fundacion Alzheimur (Murcia), the Ministerio de Educacion y Ciencia (Gobierno de Espana), Corporacion Tecnologica de Andalucia, Agencia IDEA (Consejeria de Innovacion, Junta de Andalucia), the Diabetes Research Laboratory, and the Biomedical Research Foundation. University Hospital Clinico San Carlos has been supported by CIBER de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM); CIBERDEM is an ISCIII Project.r The ROS/MAP study data were provided by the Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago. Data collection was supported through funding by NIA grants P30AG10161, R01AG15819, R01AG17917, R01AG30146, R01AG36836, U01AG32984 and U01AG46152, the Illinois Department of Public Health, and the Translational Genomics Research Institute.r The TGEN study was supported by Kronos Life Science Laboratories, the National Institute on Aging (Arizona Alzheimer's Disease Center grants P30 AG19610 and RO1 AG023193, the Mayo Clinic Alzheimer's Disease Center grant P50 AG16574, and the Intramural Research Program), the National Alzheimer's Coordinating Center (U01 AG016976), and the state of Arizona.r The authors thank the International Genomics of Alzheimer's Project (IGAP) for providing summary result data for these analyses. The investigators within IGAP contributed to the design and implementation of IGAP and/or provided data but did not participate in analysis or writing of this report. IGAP was made possible by the generous participation of the control subjects, the patients, and their families. The i-Select chip was funded by the French National Foundation on Alzheimer's disease and related disorders. European Alzheimer's Disease Initiative (EADI) was supported by the LABEX (laboratory of excellence program investment for the future) DISTALZ grant, Inserm, Institut Pasteur de Lille, Universite de Lille 2, and the Lille University Hospital. GERAD was supported by the Medical Research Council (grant no. 503480), Alzheimer's Research UK (grant no. 503176), the Wellcome Trust (grant no. 082604/2/07/Z), and German Federal Ministry of Education and Research (BMBF): Competence Network Dementia (CND) grant no.; 01GI0102, 01GI0711, 01GI0420. CHARGE was partly supported by the NIH/NIA grant R01 AG033193 and the NIA AG081220 and AGES contract N01-AG12100, the NHLBI grant R01 HL105756, the Icelandic Heart Association, and the Erasmus Medical Center and Erasmus University. ADGC was supported by the NIH/NIA grants: U01 AG032984, U24 AG021886, U01 AG016976, and the Alzheimer's Association grant ADGC-10-196728.
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- 2019
29. [Total shoulder arthroplasty under monitoring of cerebral perfusion. Report of the first case in Mexico]
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G E, Mejía-Terrazas, A J, Muñoz-García, V H, Aguirre-Rodríguez, A T, Mondragón-Rodríguez, R, López-Muñoz, and F S, Valero-González
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Aged, 80 and over ,Shoulder ,Arthroplasty, Replacement, Shoulder ,Humans ,Prospective Studies ,Mexico ,Patient Positioning - Abstract
The maintenance of cerebral perfusion during shoulder surgery performed in the beach chair position is controversial. The aim of this report is to present the first case in Mexico of a total shoulder arthroplasty performed with interscalene block and monitoring of the cerebral oxygen saturation. This monitoring was described in 1977, but only until the last decade has it reached relevance from the clinical point of view.We present an 84-year-old patient scheduled for total shoulder arthroplasty in beach chair position under regional anesthesia (ultrasound-guided interscalene block) in which the regional oxygen saturation (CrSO2) was monitored.Monitoring of cerebral oximetry is a suitable tool that allows us to have a continuous assessment throughout the transanesthetic, so we can make decisions more expeditiously. On this basis, we believe that this type of monitoring should be fundamental in patients placed in a beach chair position, as well as predominantly use regional anesthesia. In cases where it cannot be used, this monitor is absolutely essential.Desde hace algún tiempo es tema de controversia el mantenimiento de la perfusión cerebral durante la cirugía de hombro realizada en posición de silla de playa. El objetivo de este reporte es presentar el primer caso en México de una artroplastía total de hombro realizada con bloqueo interescalénico y monitoreo de la saturación cerebral de oxígeno. Este monitoreo se describió en 1977, pero sólo hasta la última década ha alcanzado relevancia desde el punto de vista clínico.Paciente de 84 años programado para artroplastía total de hombro en posición de silla de playa bajo anestesia regional tipo bloqueo interescalénico guiado por ultrasonido, en la cual se monitoreó la saturación regional de oxígeno (CrSO2).El monitoreo de la oximetría cerebral es una herramienta adecuada que nos permite tener una valoración continua durante todo el transanestésico, con lo que podemos tomar decisiones de forma más expedita. Con base en esto consideramos que este tipo de monitoreo debe ser básico en pacientes colocados en posición de silla de playa, así como el uso preponderante de anestesia regional; en los casos donde ésta no se pueda utilizar, este monitor es primordial.
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- 2018
30. [Rotator cuff tear athropathy prevalence]
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F, Guerra-Soriano, M I, Encalada-Díaz, M, Ruiz-Suárez, and F S, Valero-González
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Male ,Rotator Cuff ,Humeral Head ,Prevalence ,Humans ,Reproducibility of Results ,Female ,Rotator Cuff Injuries - Abstract
Glenohumeral arthritis secondary to massive rotator cuff tear presents with a superior displacement and femoralization of the humeral head with coracoacromial arch acetabularization. The purpose of this study was to establish prevalence of rotator cuff tear artropathy (CTA) at our institution.Four hundred electronic records were reviewed from which we identified 136 patients with rotator cuff tears. A second group was composed with patients with massive cuff tears that were analized and staged by the Seebauer cuff tear arthropathy classification.Thirty four patients with massive rotator cuff tears were identified, 8 male and 26 female (age 60.1 ± 10.26 years). Massive rotator cuff tear prevalence was 25%. CTA prevalence found in the rotator cuff group was 19 and 76% in the massive cuff tears group. Patients were staged according to the classification with 32% in stage 1a, 11% 1b, 32% 2a and 0% 2b.CTA prevalence in patients with rotator cuff tears and massive cuff tears is higher than the one reported in American population. We consider that a revision of the Seebauer classification to be appropriate to determine its reliability.La artropatía por desgarro masivo del manguito de los rotadores (ADMMR) condiciona un desplazamiento de la cabeza humeral acompañada de acetabularización del acromion y femoralización de la glenoides. El objetivo de este estudio fue conocer la prevalencia de la ADMMR en el Instituto Nacional de Rehabilitación (INR).Se realizó un estudio de prevalencia que incluyó la revisión de 400 expedientes para identificar a 136 pacientes con lesión del manguito de los rotadores. Se integró un subgrupo para pacientes con lesión masiva del manguito de los rotadores (LMMR) y ADMMR. Se estudiaron variables y se estadificaron.Se incluyeron 34 pacientes con LMMR (26 mujeres y 8 hombres) con una edad promedio de 60.1 ± 10.26 años. Se registró una prevalencia de 25% de LMMR en el grupo global con lesión del manguito de los rotadores. Asimismo, se buscó la prevalencia de ADMMR en el grupo global y en el subgrupo de lesiones masivas, siendo de 19 y 76%, respectivamente. Los pacientes con LMMR se estadificaron para conocer el grado de ADMMR mediante la clasificación de Seebauer, encontrando 32% con estadios 1a, 11% 1b, 32% 2a, 0% 2b y 23% no presentaban datos de ADMMR.La prevalencia de ADMMR en pacientes del servicio incluido con lesión del manguito de los rotadores y LMMR es mayor a la reportada en la literatura sajona.
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- 2018
31. Évaluation de l’état nutritionnel chez les patients âgés atteints de cancer : une enquête transversale nationale (NutriAgeCancer)
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A. Chah Wakilian, L. De Decker, F. Pamoukdjian, Agathe Raynaud-Simon, I. Palayer, Agnes Rouaud, Rabia Boulahssass, C. Mertens, V. Antoine, Anne-Laure Couderc, Damien Heitz, S. Valero, Boulahssass, Philippe Caillet, H. Solem Laviec, L. Cristol, and Elena Paillaud
- Subjects
Nutrition and Dietetics ,Endocrinology, Diabetes and Metabolism ,Internal Medicine - Abstract
Discipline Clinique. Introduction et but de l’etude La perte de poids est frequente chez les patients âges atteints de cancer et fortement associee a des evenements pejoratifs. Notre objectif etait d’evaluer la denutrition et la perte de poids chez les patients âges atteints de cancer. Materiel et methodes Une enquete nationale transversale (44 centres d’expertise oncogeriatrique, France) de patients atteints de cancer âges de 70 ans ou plus a ete menee de novembre a decembre 2017. Des donnees demographiques et cliniques ont ete recueillies et une evaluation nutritionnelle a ete realisee par un geriatre. Le critere de jugement principal a ete la perte de poids au cours des six derniers mois precedant le traitement anticancereux. Les patients ont ete ainsi classes en trois groupes selon le pourcentage de perte de poids ( % PDP) : minime (≤ 5 %) ; moderee (> 5 % et Resultats et analyse statistique Cinq cent soixante et onze patients etaient inclus dans l’etude (âge median : 83 ans [intervalle interquartile : 79–87], 50 % des hommes, 43 % avec des metastases). Les principaux types de cancer ont ete le cancer du sein (17 %), colorectal (14 %) et tractus digestif haut/pancreas (10 %). Au total, 124 patients (22 %) avaient une PDP modere (entre 2,5 et 11 kg ; 5,2 en moyenne) et 146 (26 %) avaient une PDP severe (entre 5 et 35 kg ; 12,1 en moyenne). En analyse univariee, les patients presentant une perte de poids moderee ou severe avaient le plus souvent un score de comorbidites plus eleve (Index de Charlson ajuste ; p = 0,018), un cancer du tractus digestif haut/pancreas et du poumon (p = 0,001), des metastases (p = 0,016), un statut de performance altere (PS ≥ 2 ; p Conclusion La moitie de la population etudiee avait perdu plus de 5 % de son poids au cours des six derniers mois. L’enquete se poursuit et sera renouvelee en 2018 permettant une analyse finale multivariee.
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- 2019
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32. Trends in electricity prices and their relation to the competitiveness and efficiency in UE countries
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C. Senabre, M. Martínez, E. Velasco, and S. Valero
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Relation (database) ,Renewable Energy, Sustainability and the Environment ,Natural resource economics ,business.industry ,Economics ,Energy Engineering and Power Technology ,Electricity ,Electrical and Electronic Engineering ,business - Published
- 2015
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33. Additional file 4: of Correlations between plasma and PET beta-amyloid levels in individuals with subjective cognitive decline: the Fundació ACE Healthy Brain Initiative (FACEHBI)
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Rojas, Itziar De, J. Romero, O. Rodríguez-Gomez, P. Pesini, A. Sanabria, A. Pérez-Cordon, C. Abdelnour, I. Hernández, M. Rosende-Roca, A. Mauleón, L. Vargas, M. Alegret, A. Espinosa, G. Ortega, S. Gil, M. Guitart, A. Gailhajanet, M. Santos-Santos, Moreno-Grau, Sonia, O. Sotolongo-Grau, S. Ruiz, L. Montrreal, E. Martín, E. Pelejà, F. Lomeña, F. Campos, A. Vivas, M. Gómez-Chiari, M. Tejero, J. Giménez, V. Pérez-Grijalba, G. Marquié, G. Monté-Rubio, S. Valero, A. Orellana, L. Tárraga, M. Sarasa, A. Ruiz, and M. Boada
- Abstract
Table S2. Exploratory analysis. (DOCX 23 kb)
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- 2018
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34. Additional file 7: of Correlations between plasma and PET beta-amyloid levels in individuals with subjective cognitive decline: the Fundació ACE Healthy Brain Initiative (FACEHBI)
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Rojas, Itziar De, J. Romero, O. Rodríguez-Gomez, P. Pesini, A. Sanabria, A. Pérez-Cordon, C. Abdelnour, I. Hernández, M. Rosende-Roca, A. Mauleón, L. Vargas, M. Alegret, A. Espinosa, G. Ortega, S. Gil, M. Guitart, A. Gailhajanet, M. Santos-Santos, Moreno-Grau, Sonia, O. Sotolongo-Grau, S. Ruiz, L. Montrreal, E. Martín, E. Pelejà, F. Lomeña, F. Campos, A. Vivas, M. Gómez-Chiari, M. Tejero, J. Giménez, V. Pérez-Grijalba, G. Marquié, G. Monté-Rubio, S. Valero, A. Orellana, L. Tárraga, M. Sarasa, A. Ruiz, and M. Boada
- Subjects
lipids (amino acids, peptides, and proteins) - Abstract
Figure S4. APOE and plasma Aβ ratios. The effects of APOE genotype on plasma Aβ levels using ANOVA between APOE ε4 carriers and noncarriers in a boxplot representation with outlier analysis. (PDF 93 kb)
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- 2018
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35. Additional file 5: of Correlations between plasma and PET beta-amyloid levels in individuals with subjective cognitive decline: the Fundació ACE Healthy Brain Initiative (FACEHBI)
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Rojas, Itziar De, J. Romero, O. Rodríguez-Gomez, P. Pesini, A. Sanabria, A. Pérez-Cordon, C. Abdelnour, I. Hernández, M. Rosende-Roca, A. Mauleón, L. Vargas, M. Alegret, A. Espinosa, G. Ortega, S. Gil, M. Guitart, A. Gailhajanet, M. Santos-Santos, Moreno-Grau, Sonia, O. Sotolongo-Grau, S. Ruiz, L. Montrreal, E. Martín, E. Pelejà, F. Lomeña, F. Campos, A. Vivas, M. Gómez-Chiari, M. Tejero, J. Giménez, V. Pérez-Grijalba, G. Marquié, G. Monté-Rubio, S. Valero, A. Orellana, L. Tárraga, M. Sarasa, A. Ruiz, and M. Boada
- Abstract
Table S3. Regression analyses between Aβ plasma ratios and FBB-PET SUVR. (DOCX 18 kb)
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- 2018
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36. Additional file 10: of Correlations between plasma and PET beta-amyloid levels in individuals with subjective cognitive decline: the Fundació ACE Healthy Brain Initiative (FACEHBI)
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Rojas, Itziar De, J. Romero, O. Rodríguez-Gomez, P. Pesini, A. Sanabria, A. Pérez-Cordon, C. Abdelnour, I. Hernández, M. Rosende-Roca, A. Mauleón, L. Vargas, M. Alegret, A. Espinosa, G. Ortega, S. Gil, M. Guitart, A. Gailhajanet, M. Santos-Santos, Moreno-Grau, Sonia, O. Sotolongo-Grau, S. Ruiz, L. Montrreal, E. Martín, E. Pelejà, F. Lomeña, F. Campos, A. Vivas, M. Gómez-Chiari, M. Tejero, J. Giménez, V. Pérez-Grijalba, G. Marquié, G. Monté-Rubio, S. Valero, A. Orellana, L. Tárraga, M. Sarasa, A. Ruiz, and M. Boada
- Abstract
Table S5. Interaction between APOE and L_TP42/40. (DOCX 14 kb)
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- 2018
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37. Additional file 8: of Correlations between plasma and PET beta-amyloid levels in individuals with subjective cognitive decline: the Fundació ACE Healthy Brain Initiative (FACEHBI)
- Author
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Rojas, Itziar De, J. Romero, O. Rodríguez-Gomez, P. Pesini, A. Sanabria, A. Pérez-Cordon, C. Abdelnour, I. Hernández, M. Rosende-Roca, A. Mauleón, L. Vargas, M. Alegret, A. Espinosa, G. Ortega, S. Gil, M. Guitart, A. Gailhajanet, M. Santos-Santos, Moreno-Grau, Sonia, O. Sotolongo-Grau, S. Ruiz, L. Montrreal, E. Martín, E. Pelejà, F. Lomeña, F. Campos, A. Vivas, M. Gómez-Chiari, M. Tejero, J. Giménez, V. Pérez-Grijalba, G. Marquié, G. Monté-Rubio, S. Valero, A. Orellana, L. Tárraga, M. Sarasa, A. Ruiz, and M. Boada
- Abstract
Figure S2. Scatter plots for FBB-PET global SUVR and Aβ plasma ratios in SCD subjects. Correlations between plasma biomarkers and brain Aβ burden. Biomarkers values plotted against SUVR values from FBB-PET imaging: FP42/40 (A), BP42/40 (B), FP42/TP42 (C), and FP40/TP40 (D). (PDF 286 kb)
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- 2018
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38. Additional file 9: of Correlations between plasma and PET beta-amyloid levels in individuals with subjective cognitive decline: the Fundació ACE Healthy Brain Initiative (FACEHBI)
- Author
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Rojas, Itziar De, J. Romero, O. Rodríguez-Gomez, P. Pesini, A. Sanabria, A. Pérez-Cordon, C. Abdelnour, I. Hernández, M. Rosende-Roca, A. Mauleón, L. Vargas, M. Alegret, A. Espinosa, G. Ortega, S. Gil, M. Guitart, A. Gailhajanet, M. Santos-Santos, Moreno-Grau, Sonia, O. Sotolongo-Grau, S. Ruiz, L. Montrreal, E. Martín, E. Pelejà, F. Lomeña, F. Campos, A. Vivas, M. Gómez-Chiari, M. Tejero, J. Giménez, V. Pérez-Grijalba, G. Marquié, G. Monté-Rubio, S. Valero, A. Orellana, L. Tárraga, M. Sarasa, A. Ruiz, and M. Boada
- Subjects
lipids (amino acids, peptides, and proteins) - Abstract
Figure S3. Linear regression between FBB-PET and Aβ TP42/40 plasma ratio in APOE ε4 stratification SCD population. A) APOE ε4 carriers; B) APOE ε4 noncarriers. (PDF 115 kb)
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- 2018
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39. Additional file 3: of Correlations between plasma and PET beta-amyloid levels in individuals with subjective cognitive decline: the Fundació ACE Healthy Brain Initiative (FACEHBI)
- Author
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Rojas, Itziar De, J. Romero, O. Rodríguez-Gomez, P. Pesini, A. Sanabria, A. Pérez-Cordon, C. Abdelnour, I. Hernández, M. Rosende-Roca, A. Mauleón, L. Vargas, M. Alegret, A. Espinosa, G. Ortega, S. Gil, M. Guitart, A. Gailhajanet, M. Santos-Santos, Moreno-Grau, Sonia, O. Sotolongo-Grau, S. Ruiz, L. Montrreal, E. Martín, E. Pelejà, F. Lomeña, F. Campos, A. Vivas, M. Gómez-Chiari, M. Tejero, J. Giménez, V. Pérez-Grijalba, G. Marquié, G. Monté-Rubio, S. Valero, A. Orellana, L. Tárraga, M. Sarasa, A. Ruiz, and M. Boada
- Abstract
Figure S1. A) Distribution of FBB-PET and plasma ratios. B) Shapiro-Wilk test for FBB-PET and plasma ratios. C) Log distributions FBB-PET and plasma ratios. D) Shapiro-Wilk test for logarithmic FBB-PET and log-plasma ratios. A, B) Distributions and Shapiro-Wilk test for plasma ratios and FBB-PET to test normality. C, D) Distributions and Shapiro-Wilk test for transformed to logarithmic plasma ratios and FBB-PET to test normality. (PDF 299 kb)
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- 2018
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40. Additional file 6: of Correlations between plasma and PET beta-amyloid levels in individuals with subjective cognitive decline: the Fundació ACE Healthy Brain Initiative (FACEHBI)
- Author
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Rojas, Itziar De, J. Romero, O. Rodríguez-Gomez, P. Pesini, A. Sanabria, A. Pérez-Cordon, C. Abdelnour, I. Hernández, M. Rosende-Roca, A. Mauleón, L. Vargas, M. Alegret, A. Espinosa, G. Ortega, S. Gil, M. Guitart, A. Gailhajanet, M. Santos-Santos, Moreno-Grau, Sonia, O. Sotolongo-Grau, S. Ruiz, L. Montrreal, E. Martín, E. Pelejà, F. Lomeña, F. Campos, A. Vivas, M. Gómez-Chiari, M. Tejero, J. Giménez, V. Pérez-Grijalba, G. Marquié, G. Monté-Rubio, S. Valero, A. Orellana, L. Tárraga, M. Sarasa, A. Ruiz, and M. Boada
- Abstract
Table S4. ANOVAs comparing APOE ε4 carriers vs noncarriers. (DOCX 14 kb)
- Published
- 2018
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41. Light-responsive peptide [2]rotaxanes as gatekeepers of mechanised nanocontainers
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Mateo Alajarin, Alberto Martinez-Cuezva, S. Valero-Moya, and Jose Berna
- Subjects
chemistry.chemical_classification ,Chemistry ,Metals and Alloys ,Nanotechnology ,Peptide ,General Chemistry ,Catalysis ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Silica nanoparticles ,Molecular shuttle ,Light responsive ,Materials Chemistry ,Ceramics and Composites - Abstract
Novel mechanized silica nanoparticles incorporating a peptide-based molecular shuttle as a photo-responsive interlocked gatekeeper of nanocontainers are described including the uptake and delivery studies of a model cargo.
- Published
- 2015
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- View/download PDF
42. [Hip osteosynthesis with IM nail: lateral decubitus without fracture table]
- Author
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V H, Aguirre-Rodríguez, G, Inzunza-Enríquez, O, Bibiano-Escalante, F J, Martínez-Ruiz, and F S, Valero-González
- Subjects
Male ,Fracture Fixation, Internal ,Hip Fractures ,Bone Screws ,Humans ,Female ,Bone Nails ,Fracture Fixation, Intramedullary - Abstract
Hip fractures have increased in the last decades, mainly in elderly patients with osteoporosis. The incidence becomes in some countries up to 250 thousand new cases per year, generating millions for health systems costs, so it should be considered a public health problem. They are treated in supine position, with a fracture table, through a lateral approach. However, it is important to know that there are other techniques, which can dispense a table of fractures and in a different position.Show a surgical technique for the treatment of transtrochanteric fractures of hip in lateral decubitus, without a fracture tab le and define its advantages and precise indications.Eight patients, five women (62.5%) and three men (37.5%). Bleeding average 115 cc and average surgical time of 67 minutes. A patient with detachment of the system that ended in Girdlestone. No neurological complications or early infection was documented.The reduction and fixation of transtrochanteric hip fractures with intramedullary nail without fracture tab le and in lateral decubitus is feasible and with a low level of associated complications.Las fracturas de cadera han aumentado en las últimas décadas, principalmente en pacientes mayores con osteoporosis. La incidencia llega a ser en algunos países de hasta 250 mil casos nuevos por año, generando costos millonarios para los sistemas de salud, por lo que se debe de considerar como un problema de salud pública. Los pacientes se tratan, de manera tradicional, en posición decúbito supino, con mesa de fracturas, a través de un abordaje lateral. Sin embargo, es importante saber que existen otras técnicas que pueden prescindir de una mesa de fracturas y en una posición diferente.Mostrar una técnica quirúrgica para el tratamiento de las fracturas transtrocantéricas de cadera en decúbito lateral, sin necesidad de mesa de fracturas y definir sus ventajas e indicaciones precisas.Ocho pacientes, cinco mujeres (62.5%) y tres hombres (37.5%). Sangrado promedio de 115 mL y tiempo quirúrgico promedio de 67 minutos. Un paciente con desanclaje del sistema terminó en Girdlestone. No se documentó ninguna complicación neurológica ni infección temprana.La reducción y fijación de fracturas transtrocantéricas de cadera con clavo centromedular sin mesa de fracturas y en decúbito lateral es factible y con un nivel bajo de complicaciones asociadas.
- Published
- 2017
43. Energy intensity of the economy as a variable to measure the energy efficiency of a country: comparison between European member states
- Author
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C. Senabre, E. Velasco, S. Valero, and A. Martínez
- Subjects
Variable (computer science) ,Renewable Energy, Sustainability and the Environment ,Member states ,Energy intensity ,Econometrics ,Measure (physics) ,Economics ,Energy Engineering and Power Technology ,Electrical and Electronic Engineering ,Efficient energy use - Published
- 2014
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44. Rupturas del tendón del supraespinoso: correlación entre RMN y hallazgos quirúrgicos.
- Author
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L. E., Salinas-Vela, V. H., Aguirre-Rodríguez, R. B., Palmieri-Bouchan, M. I., Encalada-Díaz, G. E., Mejía-Terrazas, and F. S., Valero-González
- Abstract
Copyright of Acta Ortopédica Mexicana is the property of Sociedad Mexicana de Ortopedia, AC and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
- Full Text
- View/download PDF
45. Eficacia del ácido tranexámico para disminuir el sangrado perioperatorio en artroplastía total reversa primaria.
- Author
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R. B., Palmieri-Bouchan, V. H., Aguirre-Rodríguez, L. E., Salinas-Vela, M. I., Encalada-Díaz, and F. S., Valero-González
- Abstract
Copyright of Acta Ortopédica Mexicana is the property of Sociedad Mexicana de Ortopedia, AC and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
- Full Text
- View/download PDF
46. Eccentric Overload Training and Injury Prevention during Running
- Author
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César Berzosa and Marta S Valero
- Subjects
medicine.medical_specialty ,Vitamin supplement ,Protein diet ,business.industry ,Injury prevention ,Physical therapy ,Medicine ,Eccentric ,business ,Omics ,Bioinformatics - Published
- 2017
- Full Text
- View/download PDF
47. Exploring APOE genotype effects on Alzheimer's disease risk and amyloid β burden in individuals with subjective cognitive decline: The FundacioACE Healthy Brain Initiative (FACEHBI) study baseline results
- Author
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O. Rodríguez-Gómez, O. Sotolongo-Grau, M. Berthier, Francisco Lomeña, Miguel A. Santos-Santos, M. Boada, Assumpta Vivas, J. Martínez, C. Abdelnour, S. Preckler, Adelina Orellana, M. Moreno, I. de Rojas, G. Ortega, S. Diego, S. Ruiz, A. Mauleón, Judith Papasey, M. Rosende-Roca, A. Orellana, S. Bullich, J. Giménez, M. Torres, P. Pesini, Marina Guitart, Octavio Rodriguez-Gomez, A. Pérez-Cordon, M. Gómez-Chiari, J. Romero, Itziar de Rojas, Montserrat Alegret, A. Páez, P. Cañabate, Marta Gómez-Chiari, Lluís Tárraga, Liliana Vargas, Asunción Lafuente, M. Guitart, Carla Abdelnour, M. Buendia, Miguel Angel Tejero, Anna Gailhajanet, F. Lomeña, Isabel Hernández, L. Vargas, E. Martín, Agustín Ruiz, Sergi Valero, M.A. Santos-Santos, L. Tárraga, F. Campos, Oscar Sotolongo-Grau, M.A. Tejero, Esther Peleja, L. Núñez, Ana Mauleón, Silvia Gil, Alba Pérez-Cordón, Sonia Moreno–Grau, A. Vivas, V. Pérez-Grijalba, E. Pelejà, M. Ibarria, A. Ruiz, N. Aguilera, M. Sarasa, A. Sanabria, C. Cuevas, Ana Espinosa, Joan Giménez, A. Espinosa, Angela Sanabria, Domingo Sánchez-Ruiz, Nuria Aguilera, R. Gismondi, A. Lafuente, G. Monté, A. Pancho, Gemma Ortega, J. Pavía, Manuel Serrano-Ríos, D. Sánchez-Ruiz, S. Moreno-Grau, Mercè Boada, S. Gil, I. Hernández, Maitée Rosende-Roca, M. Alegret, S. Valero, A. Gailhajenet, B. Hernández-Olasagarre, Francisco Campos, Susana Ruiz, and E. L. Martin
- Subjects
Male ,0301 basic medicine ,Apolipoprotein E ,Oncology ,Amyloid ,medicine.medical_specialty ,Genotype ,Epidemiology ,Apolipoprotein E4 ,Neuroimaging ,Disease ,Diagnostic Self Evaluation ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Malalties del sistema nerviós ,0302 clinical medicine ,Meta-Analysis as Topic ,Developmental Neuroscience ,Alzheimer Disease ,Risk Factors ,Internal medicine ,medicine ,Humans ,Cognitive Dysfunction ,Cognitive decline ,Allele ,Psychiatry ,Alleles ,business.industry ,Health Policy ,Brain ,Middle Aged ,Alzheimer's disease ,Nervous system diseases ,Psychiatry and Mental health ,Cross-Sectional Studies ,030104 developmental biology ,Malaltia d'Alzheimer ,Spain ,Endophenotype ,Cohort ,Biomarker (medicine) ,Female ,Neurology (clinical) ,Geriatrics and Gerontology ,business ,Biomarkers ,030217 neurology & neurosurgery - Abstract
Introduction Subjective cognitive decline (SCD) has been proposed as a potential preclinical stage of Alzheimer's disease (AD). Nevertheless, the genetic and biomarker profiles of SCD individuals remain mostly unexplored. Methods We evaluated apolipoprotein E ( APOE ) e4's effect in the risk of presenting SCD, using the Fundacio ACE Healthy Brain Initiative (FACEHBI) SCD cohort and Spanish controls, and performed a meta-analysis addressing the same question. We assessed the relationship between APOE dosage and brain amyloid burden in the FACEHBI SCD and Alzheimer's Disease Neuroimaging Initiative cohorts. Results Analysis of the FACEHBI cohort and the meta-analysis demonstrated SCD individuals presented higher allelic frequencies of APOE e4 with respect to controls. APOE dosage explained 9% (FACEHBI cohort) and 11% (FACEHBI and Alzheimer's Disease Neuroimaging Initiative cohorts) of the variance of cerebral amyloid levels. Discussion The FACEHBI sample presents APOE e4 enrichment, suggesting that a pool of AD patients is nested in our sample. Cerebral amyloid levels are partially explained by the APOE allele dosage, suggesting that other genetic or epigenetic factors are involved in this AD endophenotype.
- Published
- 2017
48. [Shoulder arthroplasty in the private practice. Analysis of demographics and comorbid conditions in a sample of 120 patients]
- Author
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R, López-Muñoz, M I, Encalada-Díaz, T, Mondragón-Rodríguez, V H, Aguirre-Rodríguez, and F S, Valero-González
- Subjects
Aged, 80 and over ,Male ,Rotator Cuff ,Shoulder Joint ,Humans ,Female ,Arthroplasty, Replacement ,Middle Aged ,Shoulder Injuries ,Mexico ,Aged ,Follow-Up Studies ,Rotator Cuff Injuries - Abstract
To describe the demographics in a series of shoulder arthroplasty cases operated in a single hospital and by the same surgical team.120 shoulder arthroplasties performed between January 2006 and November 2014 were included. The following variables were analyzed: age, gender, baseline diagnosis, type of prosthesis used, comorbid conditions, involved side, occupation, follow-up time, and surgical history.Females accounted for 66% and males 34%; mean age was 66 years and the most frequent diagnosis was arthropathy resulting from rotator cuff tear (30%). The reverse total shoulder prosthesis was used in 51% of cases, followed by the hemiprosthesis in 38%. Seventy per cent of patients were from the Federal District. Arterial hypertension occurred in 23% of cases; 36% of cases had undergone prior surgery; 40% of cases worked at home.Shoulder arthroplasty is a procedure frequently performed at this hospital. Our case series reports a significant number of cases in which the demographics may give us an overview of shoulder arthroplasty in Mexican patients and describe the characteristics of patients eligible for this procedure, as there are no other registries available.
- Published
- 2016
49. [Reverse shoulder prosthesis]
- Author
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F S, Valero-González
- Subjects
Shoulder Joint ,Joint Prosthesis ,Humans ,Arthroplasty, Replacement ,Prosthesis Design - Published
- 2016
50. Distance-Based Measures of Association with Applications in Relating Hyperspectral Images
- Author
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Daniel Cuadras, Jocelyn Chanussot, Philippe Salembier, Carles M. Cuadras, S. Valero, Universitat Politècnica de Catalunya [Barcelona] (UPC), Statistical Assessment Service, Institut d'Investigació Biomèdica de Bellvitge [Barcelone] (IDIBELL), GIPSA - Signal Images Physique (GIPSA-SIGMAPHY), Département Images et Signal (GIPSA-DIS), Grenoble Images Parole Signal Automatique (GIPSA-lab), Université Stendhal - Grenoble 3-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Stendhal - Grenoble 3-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Grenoble Images Parole Signal Automatique (GIPSA-lab), and Université Stendhal - Grenoble 3-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Stendhal - Grenoble 3-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Statistics and Probability ,Hellinger distance ,Multivariate statistics ,Correlation and dependence ,02 engineering and technology ,01 natural sciences ,Metric multidimensional scaling ,010104 statistics & probability ,[INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing ,Wilks lambda ,Statistics ,0202 electrical engineering, electronic engineering, information engineering ,Mixed variables ,0101 mathematics ,Categorical variable ,Mathematics ,business.industry ,Hyperspectral imaging ,Pattern recognition ,Binary partition tree ,Canonical correlations ,020201 artificial intelligence & image processing ,Artificial intelligence ,business ,[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing ,Distance based - Abstract
Work supported in part by MEC (Spain) grant MTM2008-00642; International audience; We propose a distance-based method to relate two data sets. We define and study some measures of multivariate association based on distances between observations. The proposed approach can be used to deal with general data sets (e.g., observations on continuous, categorical or mixed variables). An application, using Hellinger distance, provides the relationships between two regions of hyperspectral images.
- Published
- 2012
- Full Text
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