16 results on '"S. Tosaki"'
Search Results
2. Enhancing laser beam performance by interfering intense laser beamlets
- Author
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H. Nishimura, Akifumi Yogo, Yuki Abe, S. Sakata, Seung Ho Lee, Takayoshi Norimatsu, K. Mima, J. Kawanaka, Hiroshi Azechi, Yasunobu Arikawa, N. Kamitsukasa, S. Tosaki, Alessio Morace, Alexander Andreev, Kazuki Matsuo, R. Kodama, Hiroyuki Shiraga, Yoichi Sakawa, X. Vaisseau, N. Iwata, M. Nakai, Yasuhiko Sentoku, Shinsuke Fujioka, N. Miyanaga, Sadaoki Kojima, Masayasu Hata, and Shigeki Tokita
- Subjects
0301 basic medicine ,Photon ,Nonlinear optics ,Science ,General Physics and Astronomy ,Physics::Optics ,02 engineering and technology ,Electron ,Interference (wave propagation) ,General Biochemistry, Genetics and Molecular Biology ,Article ,Ion ,law.invention ,Plasma physics ,03 medical and health sciences ,Optics ,Ultrafast photonics ,law ,Physics::Atomic Physics ,Absorption (electromagnetic radiation) ,lcsh:Science ,Physics ,Multidisciplinary ,business.industry ,Energy conversion efficiency ,General Chemistry ,021001 nanoscience & nanotechnology ,Laser ,030104 developmental biology ,lcsh:Q ,0210 nano-technology ,business ,Beam (structure) - Abstract
Increasing the laser energy absorption into energetic particle beams represents a longstanding quest in intense laser-plasma physics. During the interaction with matter, part of the laser energy is converted into relativistic electron beams, which are the origin of secondary sources of energetic ions, γ-rays and neutrons. Here we experimentally demonstrate that using multiple coherent laser beamlets spatially and temporally overlapped, thus producing an interference pattern in the laser focus, significantly improves the laser energy conversion efficiency into hot electrons, compared to one beam with the same energy and nominal intensity as the four beamlets combined. Two-dimensional particle-in-cell simulations support the experimental results, suggesting that beamlet interference pattern induces a periodical shaping of the critical density, ultimately playing a key-role in enhancing the laser-to-electron energy conversion efficiency. This method is rather insensitive to laser pulse contrast and duration, making this approach robust and suitable to many existing facilities., Enhanced coupling of laser energy to the target particles is a fundamental issue in laser-plasma interactions. Here the authors demonstrate increased photon absorption leading into higher laser to electron and proton energy transfer through the interference of multiple coherent beamlets.
- Published
- 2018
3. Evaluation of laser-driven ion energies for fusion fast-ignition research
- Author
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S. Shokita, Hiroaki Nishimura, Shinsuke Fujioka, Akifumi Yogo, Alessio Morace, Hiroyuki Shiraga, Keisuke Koga, Mitsuo Nakai, S. Tosaki, Yasunobu Arikawa, Hiroshi Azechi, and Kazuki Okamoto
- Subjects
Ignition system ,Physics ,Fusion ,law ,0103 physical sciences ,General Physics and Astronomy ,Atomic physics ,010306 general physics ,Laser ,01 natural sciences ,010305 fluids & plasmas ,law.invention ,Ion - Published
- 2017
- Full Text
- View/download PDF
4. Boosting laser-ion acceleration with multi-picosecond pulses
- Author
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N. Iwata, Takayoshi Norimatsu, H. Shiraga, Kazuki Matsuo, N. Kamitsukasa, N. Miyanaga, Kohei Yamanoi, Akito Sagisaka, Yasunobu Arikawa, Akifumi Yogo, Shigeki Tokita, Sergei V. Bulanov, Sadaoki Kojima, Kunioki Mima, Shinsuke Fujioka, Mitsuo Nakai, Hitoshi Sakagami, Tomoyuki Johzaki, J. Kawanaka, Yasuhiko Sentoku, Hiroshi Azechi, Alessio Morace, Kiminori Kondo, Hideo Nagatomo, Hiroaki Nishimura, S. Tosaki, and Masakatsu Murakami
- Subjects
Multidisciplinary ,Materials science ,Proton ,Nuclear Theory ,Energy conversion efficiency ,Pulse duration ,Laser ,01 natural sciences ,Article ,Ponderomotive energy ,010305 fluids & plasmas ,Ion ,law.invention ,Physics::Plasma Physics ,law ,Picosecond ,0103 physical sciences ,Physics::Accelerator Physics ,Electron temperature ,Atomic physics ,Nuclear Experiment ,010306 general physics - Abstract
Using one of the world most powerful laser facility, we demonstrate for the first time that high-contrast multi-picosecond pulses are advantageous for proton acceleration. By extending the pulse duration from 1.5 to 6 ps with fixed laser intensity of 1018 W cm−2, the maximum proton energy is improved more than twice (from 13 to 33 MeV). At the same time, laser-energy conversion efficiency into the MeV protons is enhanced with an order of magnitude, achieving 5% for protons above 6 MeV with the 6 ps pulse duration. The proton energies observed are discussed using a plasma expansion model newly developed that takes the electron temperature evolution beyond the ponderomotive energy in the over picoseconds interaction into account. The present results are quite encouraging for realizing ion-driven fast ignition and novel ion beamlines.
- Published
- 2017
- Full Text
- View/download PDF
5. Laser Propagation in Nanostructured Ultra-Low-Density Materials
- Author
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K. Koga, J. D. Colvin, S. Tosaki, N. Tanaka, Akifumi Yogo, Zhe Zhang, K. B. Fournier, Gregory Kemp, Hiraku Matsukuma, and H. Nishimura
- Subjects
Materials science ,Nanostructure ,Yield (engineering) ,Physics::Instrumentation and Detectors ,business.industry ,Nanotechnology ,Aerogel ,Laser ,law.invention ,law ,Ionization ,Low density ,Optoelectronics ,Physics::Atomic Physics ,Laser heating ,business - Abstract
The nanostructure of very-low-density aerogels (< 10 mg/cm3) affects the laser heating and propagation of the subsequent heat front. Simulations treat these materials as an atomistic medium without any structure differentiating between near-solid-density material and voids. Thus, simulations fail to predict the effects of the aerogel’s physical micro or nanostructure on the laser-matter interaction. We have designed an experiment using the GEKKO XII laser and ILE diagnostics to characterize the ionization-wave propagation and x-ray yield from aerogel and mass-matched gaseous targets as the laser passes through each. By design, the gas and aerogel targets will have identical densities and identical effective ionization states.
- Published
- 2016
- Full Text
- View/download PDF
6. Production of intense, pulsed, and point-like neutron source from deuterated plastic cavity by mono-directional kilo-joule laser irradiation
- Author
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Yasunobu Arikawa, Takao Nagai, Katsunobu Nishihara, T. Ikenouchi, Hiroaki Nishimura, Atsushi Sunahara, T. Kawashima, Takeshi Watari, Yuki Abe, Hitoshi Sakagami, Hiroshi Azechi, Shinsuke Fujioka, Nakahiro Satoh, Takayoshi Norimatsu, T. Yanagawa, S. Tosaki, K. Mima, Sadaoki Kojima, Mitsuo Nakai, Seung Ho Lee, Alessio Morace, Hiroyuki Shiraga, S. Sakata, Zhe Zhang, and Akifumi Yogo
- Subjects
Thermonuclear fusion ,Materials science ,Physics and Astronomy (miscellaneous) ,business.industry ,Physics::Optics ,Hot spot (veterinary medicine) ,Laser ,01 natural sciences ,010305 fluids & plasmas ,law.invention ,Optics ,law ,0103 physical sciences ,Physics::Accelerator Physics ,Nuclear fusion ,Neutron source ,Neutron ,Irradiation ,010306 general physics ,business ,Beam (structure) - Abstract
This paper reports an experimental investigation of a scheme to produce an intense, pulsed, point-like, and quasi-monoenergy neutron source. In this scheme, the inner wall of a deuterated plastic spherical cavity is mono-directionally irradiated by a 2.4 kJ laser beam through an open-tip gold cone inserted into the cavity. The whole inner wall of the cavity is illuminated by laser light owing to multiple laser reflections, and the laser-ablated plasma stagnates near the center of the cavity, at which a several keV hot spot is generated. Thermonuclear and beam D-D fusion reactions occur in the hot spot. We have demonstrated the neutron yield exceeding 107 neutrons per pulse from a
- Published
- 2017
- Full Text
- View/download PDF
7. Plasma mirror implementation on LFEX laser for ion and fast electron fast ignition
- Author
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Kazuki Matsuo, S. Tosaki, Kotaro Kondo, Yasunobu Arikawa, Sadaoki Kojima, Mitsuo Nakai, Alessio Morace, S. Sakata, Akito Sagisaka, Hiroyuki Shiraga, Akifumi Yogo, Yuki Abe, Takahisa Jitsuno, Alexander S. Pirozhkov, Shinsuke Fujioka, N. Miyanaga, Seung Ho Lee, Takayoshi Norimatsu, Hiroaki Nishimura, and Hiroshi Azechi
- Subjects
Nuclear and High Energy Physics ,Materials science ,Proton ,business.industry ,Electron ,Plasma ,Condensed Matter Physics ,Laser ,01 natural sciences ,010305 fluids & plasmas ,Ion ,law.invention ,Pulse (physics) ,Ignition system ,Optics ,law ,0103 physical sciences ,Particle-in-cell ,010306 general physics ,business - Abstract
In this work we report the successful implementation of plasma mirror (PM) technology on an LFEX laser facility at the Institute of Laser Engineering, Osaka University. The LFEX laser pulse was successfully refocused at the target chamber center (TCC) by means of a spherical plasma mirror, resulting in 5 × 1018 W cm−2 laser intensity, with 45% reflectivity at a laser flux of about 90 J cm−2 on the PM. Experimental results show stable focusing and pointing of the LFEX pulse after PM refocusing. The contrast improvement was demonstrated by both cooler fast electron slope temperature distribution as well as by the ability to shoot sub-µm plastic foils obtaining proton beams with maximum energy exceeding 20 MeV. Experimental results are qualitatively reproduced by 2D particle in cell simulations.
- Published
- 2017
- Full Text
- View/download PDF
8. Improvement in the heating efficiency of fast ignition inertial confinement fusion through suppression of the preformed plasma
- Author
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Y. Hironaka, Zhe Zhang, Akifumi Yogo, Toshiyuki Kawashima, T. Ozaki, Masayasu Hata, Shigeki Tokita, Takahisa Jitsuno, S. Lee, Yasunobu Arikawa, N. Miyanaga, Hitoshi Sakagami, S. Tosaki, S. Matsubara, Hiroyuki Shiraga, Hideo Nagatomo, Takayoshi Norimatsu, Yasushi Fujimoto, K. Yamanoi, Yuki Abe, T. Gawa, Keisuke Shigemori, Shinsuke Fujioka, Sadaoki Kojima, Mitsuo Nakai, King Fai Farley Law, J. Kawanaka, X. Vaisseau, Atsushi Sunahara, Tomoyuki Johzaki, Y. Kato, Yoshiki Nakata, Hiroaki Nishimura, Kazuki Matsuo, Hiroshi Azechi, Alessio Morace, and Shohei Sakata
- Subjects
Nuclear and High Energy Physics ,Range (particle radiation) ,Materials science ,Plasma parameters ,Pulse duration ,Plasma ,Electron ,Condensed Matter Physics ,Laser ,01 natural sciences ,Encircled energy ,010305 fluids & plasmas ,law.invention ,law ,0103 physical sciences ,Atomic physics ,010306 general physics ,Inertial confinement fusion - Abstract
The study of fast electron spectrum optimization by suppression of preformed plasma in fast ignition targets is presented in this work. Integrated fast-electron spectra for electron energies below 3 MeV—the energy range responsible for core heating—are compared for different preformed plasma conditions. The pulse contrast (the ratio of peak-to-pedestal laser intensities) is compared for 108, 109 and 1011 conditions at constant laser energy (~500 J), pulse duration (2 ps), spot size (30% encircled energy on 50 µm diameter) and laser intensity (around 1 × 1019 W cm−2). The best electron spectrum optimization, consisting of maximized electron number for energies below 3 MeV was obtained with 14 µm thick cone targets. The energy coupling efficiency from heating laser to core plasma, assuming typical core plasma parameters, was estimated to be 2%, although 0.37% was obtained with previous conditions with poor pulse contrast and a 7 µm thick cone target.
- Published
- 2017
- Full Text
- View/download PDF
9. Surface hardness change of restorative filling materials stored in saliva
- Author
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K Okada, K Hirota, Wyatt R. Hume, and S Tosaki
- Subjects
Saliva ,Materials science ,Surface Properties ,Drug Storage ,Composite number ,Glass ionomer cement ,Dentistry ,Electron microprobe ,Composite Resins ,X-ray photoelectron spectroscopy ,Hardness ,Materials Testing ,Humans ,General Materials Science ,Dental Restoration, Permanent ,General Dentistry ,Compomers ,business.industry ,Silicates ,Spectrometry, X-Ray Emission ,Water ,Hydrogels ,Silicon Dioxide ,Distilled water ,Glass Ionomer Cements ,Mechanics of Materials ,Vickers hardness test ,Methacrylates ,Zirconium ,business ,Nuclear chemistry - Abstract
Objectives: This study was to investigate the effect of saliva used as storage liquid and the length of storage effect on surface hardnesses of Fuji IX GP (FIX), Dyract (DR), Z-100 and Estio LC (ELC). Methods: The materials were mixed according to the manufacturers' instructions and immersed in distilled water or human parotid saliva. Vickers hardness number (HVN) was measured 1, 7, 20 and 40 days after the materials were mixed. HVN was calculated from the indentation diameter after 100 or 300 g loading on their surface for 15 s. The two methods of characterization used in this work were X-ray photoelectron spectroscopy (XPS) for surface chemical composition and electron probe microanalysis (EPMA) for depth profile analysis. Results: Only in FIX, did HVN increase with time at both storage conditions, distilled water and saliva. The increase rate of the value was higher when stored in saliva than distilled water. After 40 days storage in saliva, the HVN value of FIX increased by 39%. The increase for storage in saliva for DR was 22%, ELC 16%, and Z100 3%, compared to 1 day storage in distilled water. Ca and P peaks caused by saliva were detected by XPS and EPMA analysis, but these peaks did not exist in either composite resin or polyacid-modified composite resin by EPMA analysis. Significance: Saliva has the remarkable effect of increasing surface hardness of Fuji IX GP.
- Published
- 2001
- Full Text
- View/download PDF
10. Energy distribution of fast electrons accelerated by high intensity laser pulse depending on laser pulse duration
- Author
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S. Lee, Tetsuo Ozaki, Alessio Morace, Akifumi Yogo, Hiroaki Nishimura, Atsushi Sunahara, Masayasu Hata, H. Shiraga, King Fai Farley Law, Shinsuke Fujioka, Tomoyuki Johzaki, Shohei Sakata, Yasunobu Arikawa, S. Tosaki, Hitoshi Sakagami, Hiroshi Azechi, Kazuki Matsuo, Sadaoki Kojima, Mitsuo Nakai, and Hideo Nagatomo
- Subjects
History ,Materials science ,business.industry ,Pulse duration ,Plasma ,Electron ,Laser ,01 natural sciences ,Electromagnetic radiation ,010305 fluids & plasmas ,Computer Science Applications ,Education ,Intensity (physics) ,law.invention ,Pulse (physics) ,Full width at half maximum ,Optics ,law ,0103 physical sciences ,010306 general physics ,business - Abstract
The dependence of high-energy electron generation on the pulse duration of a high intensity LFEX laser was experimentally investigated. The LFEX laser (λ = 1.054 and intensity = 2.5 – 3 x 1018 W/cm2) pulses were focused on a 1 mm3 gold cubic block after reducing the intensities of the foot pulse and pedestal by using a plasma mirror. The full width at half maximum (FWHM) duration of the intense laser pulse could be set to either 1.2 ps or 4 ps by temporally stacking four beams of the LFEX laser, for which the slope temperature of the high-energy electron distribution was 0.7 MeV and 1.4 MeV, respectively. The slope temperature increment cannot be explained without considering pulse duration effects on fast electron generation.
- Published
- 2016
- Full Text
- View/download PDF
11. Fast ignition realization experiment with high-contrast kilo-joule peta-watt LFEX laser and strong external magnetic field
- Author
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Yasunobu Arikawa, Atsushi Sunahara, Yoichiro Hironaka, Tomoyuki Johzaki, Takashi Shiroto, S. Tosaki, Claudio Bellei, Hiroshi Sawada, Yuki Abe, Tetsuo Ozaki, Junji Kawanaka, Shohei Sakata, Takayoshi Norimatsu, Hiroshi Azechi, S. Lee, H. Shiraga, Zhe Zhang, Hitoshi Sakagami, Sadaoki Kojima, Takahisa Jitsuno, Mitsuo Nakai, Kunioki Mima, Mathieu Bailly-Grandvaux, Hiroaki Nishimura, Noriaki Miyanaga, Alessio Morace, Akifumi Yogo, King Fai Farley Law, Shigeki Tokita, Kazuki Matsuo, Joao Santos, Yoshiki Nakata, Yasushi Fujimoto, Naofumi Ohnishi, Kohei Yamanoi, Kotaro Kondo, Keisuke Shigemori, Shinsuke Fujioka, Hideo Nagatomo, and X. Vaisseau
- Subjects
Shock wave ,Physics ,business.industry ,Implosion ,Plasma ,Condensed Matter Physics ,Laser ,01 natural sciences ,010305 fluids & plasmas ,law.invention ,Magnetic mirror ,Optics ,law ,0103 physical sciences ,Relativistic electron beam ,Plasma diagnostics ,010306 general physics ,business ,Inertial confinement fusion - Abstract
A petawatt laser for fast ignition experiments (LFEX) laser system [N. Miyanaga et al., J. Phys. IV France 133, 81 (2006)], which is currently capable of delivering 2 kJ in a 1.5 ps pulse using 4 laser beams, has been constructed beside the GEKKO-XII laser facility for demonstrating efficient fast heating of a dense plasma up to the ignition temperature under the auspices of the Fast Ignition Realization EXperiment (FIREX) project [H. Azechi et al., Nucl. Fusion 49, 104024 (2009)]. In the FIREX experiment, a cone is attached to a spherical target containing a fuel to prevent a corona plasma from entering the path of the intense heating LFEX laser beams. The LFEX laser beams are focused at the tip of the cone to generate a relativistic electron beam (REB), which heats a dense fuel core generated by compression of a spherical deuterized plastic target induced by the GEKKO-XII laser beams. Recent studies indicate that the current heating efficiency is only 0.4%, and three requirements to achieve higher efficiency of the fast ignition (FI) scheme with the current GEKKO and LFEX systems have been identified: (i) reduction of the high energy tail of the REB; (ii) formation of a fuel core with high areal density using a limited number (twelve) of GEKKO-XII laser beams as well as a limited energy (4 kJ of 0.53-μm light in a 1.3 ns pulse); (iii) guiding and focusing of the REB to the fuel core. Laser–plasma interactions in a long-scale plasma generate electrons that are too energetic to efficiently heat the fuel core. Three actions were taken to meet the first requirement. First, the intensity contrast of the foot pulses to the main pulses of the LFEX was improved to >109. Second, a 5.5-mm-long cone was introduced to reduce pre-heating of the inner cone wall caused by illumination of the unconverted 1.053-μm light of implosion beam (GEKKO-XII). Third, the outside of the cone wall was coated with a 40-μm plastic layer to protect it from the pressure caused by imploding plasma. Following the above improvements, conversion of 13% of the LFEX laser energy to a low energy portion of the REB, whose slope temperature is 0.7 MeV, which is close to the ponderomotive scaling value, was achieved. To meet the second requirement, the compression of a solid spherical ball with a diameter of 200-μm to form a dense core with an areal density of ∼0.07 g/cm2 was induced by a laser-driven spherically converging shock wave. Converging shock compression is more hydrodynamically stable compared to shell implosion, while a hot spot cannot be generated with a solid ball target. Solid ball compression is preferable also for compressing an external magnetic field to collimate the REB to the fuel core, due to the relatively small magnetic Reynolds number of the shock compressed region. To meet the third requirement, we have generated a strong kilo-tesla magnetic field using a laser-driven capacitor-coil target. The strength and time history of the magnetic field were characterized with proton deflectometry and a B-dot probe. Guidance of the REB using a 0.6-kT field in a planar geometry has been demonstrated at the LULI 2000 laser facility. In a realistic FI scenario, a magnetic mirror is formed between the REB generation point and the fuel core. The effects of the strong magnetic field on not only REB transport but also plasma compression were studied using numerical simulations. According to the transport calculations, the heating efficiency can be improved from 0.4% to 4% by the GEKKO and LFEX laser system by meeting the three requirements described above. This efficiency is scalable to 10% of the heating efficiency by increasing the areal density of the fuel core.
- Published
- 2016
- Full Text
- View/download PDF
12. Plasma mirror implementation on LFEX laser for ion and fast electron fast ignition.
- Author
-
A. Morace, S. Kojima, Y. Arikawa, S. Fujioka, A. Yogo, S. Tosaki, S. Sakata, Y. Abe, S.H. Lee, K. Matsuo, A. Sagisaka, K. Kondo, A.S. Pirozhkov, T. Norimatsu, T. Jitsuno, N. Miyanaga, H. Shiraga, M. Nakai, H. Nishimura, and H. Azechi
- Subjects
MAGNETICS ,LASER pulses ,ELECTRON emission ,TEMPERATURE distribution ,PROTON beams - Abstract
In this work we report the successful implementation of plasma mirror (PM) technology on an LFEX laser facility at the Institute of Laser Engineering, Osaka University. The LFEX laser pulse was successfully refocused at the target chamber center (TCC) by means of a spherical plasma mirror, resulting in 5 × 10
18 W cm−2 laser intensity, with 45% reflectivity at a laser flux of about 90 J cm−2 on the PM. Experimental results show stable focusing and pointing of the LFEX pulse after PM refocusing. The contrast improvement was demonstrated by both cooler fast electron slope temperature distribution as well as by the ability to shoot sub-µm plastic foils obtaining proton beams with maximum energy exceeding 20 MeV. Experimental results are qualitatively reproduced by 2D particle in cell simulations. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
13. Enhancing laser beam performance by interfering intense laser beamlets.
- Author
-
Morace A, Iwata N, Sentoku Y, Mima K, Arikawa Y, Yogo A, Andreev A, Tosaki S, Vaisseau X, Abe Y, Kojima S, Sakata S, Hata M, Lee S, Matsuo K, Kamitsukasa N, Norimatsu T, Kawanaka J, Tokita S, Miyanaga N, Shiraga H, Sakawa Y, Nakai M, Nishimura H, Azechi H, Fujioka S, and Kodama R
- Abstract
Increasing the laser energy absorption into energetic particle beams represents a longstanding quest in intense laser-plasma physics. During the interaction with matter, part of the laser energy is converted into relativistic electron beams, which are the origin of secondary sources of energetic ions, γ-rays and neutrons. Here we experimentally demonstrate that using multiple coherent laser beamlets spatially and temporally overlapped, thus producing an interference pattern in the laser focus, significantly improves the laser energy conversion efficiency into hot electrons, compared to one beam with the same energy and nominal intensity as the four beamlets combined. Two-dimensional particle-in-cell simulations support the experimental results, suggesting that beamlet interference pattern induces a periodical shaping of the critical density, ultimately playing a key-role in enhancing the laser-to-electron energy conversion efficiency. This method is rather insensitive to laser pulse contrast and duration, making this approach robust and suitable to many existing facilities.
- Published
- 2019
- Full Text
- View/download PDF
14. Boosting laser-ion acceleration with multi-picosecond pulses.
- Author
-
Yogo A, Mima K, Iwata N, Tosaki S, Morace A, Arikawa Y, Fujioka S, Johzaki T, Sentoku Y, Nishimura H, Sagisaka A, Matsuo K, Kamitsukasa N, Kojima S, Nagatomo H, Nakai M, Shiraga H, Murakami M, Tokita S, Kawanaka J, Miyanaga N, Yamanoi K, Norimatsu T, Sakagami H, Bulanov SV, Kondo K, and Azechi H
- Abstract
Using one of the world most powerful laser facility, we demonstrate for the first time that high-contrast multi-picosecond pulses are advantageous for proton acceleration. By extending the pulse duration from 1.5 to 6 ps with fixed laser intensity of 10
18 W cm-2 , the maximum proton energy is improved more than twice (from 13 to 33 MeV). At the same time, laser-energy conversion efficiency into the MeV protons is enhanced with an order of magnitude, achieving 5% for protons above 6 MeV with the 6 ps pulse duration. The proton energies observed are discussed using a plasma expansion model newly developed that takes the electron temperature evolution beyond the ponderomotive energy in the over picoseconds interaction into account. The present results are quite encouraging for realizing ion-driven fast ignition and novel ion beamlines.- Published
- 2017
- Full Text
- View/download PDF
15. Discovery of new chemotype dipeptidyl peptidase IV inhibitors having (R)-3-amino-3-methyl piperidine as a pharmacophore.
- Author
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Nishio Y, Kimura H, Tosaki S, Sugaru E, Sakai M, Horiguchi M, Masui Y, Ono M, Nakagawa T, and Nakahira H
- Subjects
- Animals, Dipeptidyl Peptidase 4 metabolism, Dipeptidyl-Peptidase IV Inhibitors chemical synthesis, Dipeptidyl-Peptidase IV Inhibitors pharmacokinetics, Drug Evaluation, Preclinical, Humans, Microsomes, Liver metabolism, Piperidines chemical synthesis, Piperidines pharmacokinetics, Pyrimidinones chemical synthesis, Pyrimidinones pharmacokinetics, Rats, Stereoisomerism, Structure-Activity Relationship, Dipeptidyl Peptidase 4 chemistry, Dipeptidyl-Peptidase IV Inhibitors chemistry, Piperidines chemistry, Pyrimidinones chemistry
- Abstract
Structures containing the (R)-3-amino-3-methyl piperidine unit as a new pharmacophore moiety have been shown to possess moderate inhibitory activity for DPP-4 with good pharmacokinetics profile. One of these compounds was found to have good oral bioavailability and PK/PD profile in ZF-rat., (Copyright © 2010 Elsevier Ltd. All rights reserved.)
- Published
- 2010
- Full Text
- View/download PDF
16. Surface hardness change of restorative filling materials stored in saliva.
- Author
-
Okada K, Tosaki S, Hirota K, and Hume WR
- Subjects
- Dental Restoration, Permanent methods, Drug Storage, Hardness, Humans, Hydrogels chemistry, Materials Testing, Methacrylates, Silicates, Silicon Dioxide, Spectrometry, X-Ray Emission, Surface Properties, Water chemistry, Zirconium, Compomers chemistry, Composite Resins chemistry, Glass Ionomer Cements chemistry, Saliva chemistry
- Abstract
Objectives: This study was to investigate the effect of saliva used as storage liquid and the length of storage effect on surface hardnesses of Fuji IX (GP) (FIX), Dyract (DR), Z-100 and Estio LC (ELC)., Methods: The materials were mixed according to the manufacturers' instructions and immersed in distilled water or human parotid saliva. Vickers hardness number (HVN) was measured 1, 7, 20 and 40 days after the materials were mixed. HVN was calculated from the indentation diameter after 100 or 300g loading on their surface for 15s. The two methods of characterization used in this work were X-ray photoelectron spectroscopy (XPS) for surface chemical composition and electron probe microanalysis (EPMA) for depth profile analysis., Results: Only in FIX, did HVN increase with time at both storage conditions, distilled water and saliva. The increase rate of the value was higher when stored in saliva than distilled water. After 40 days storage in saliva, the HVN value of FIX increased by 39%. The increase for storage in saliva for DR was 22%, ELC 16%, and Z100 3%, compared to 1 day storage in distilled water. Ca and P peaks caused by saliva were detected by XPS and EPMA analysis, but these peaks did not exist in either composite resin or polyacid-modified composite resin by EPMA analysis., Significance: Saliva has the remarkable effect of increasing surface hardness of Fuji IX (GP).
- Published
- 2001
- Full Text
- View/download PDF
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