157 results on '"S. Topuz"'
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2. Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study
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Fabio Medas, Chiara Dobrinja, Ebtesam Abdullah Al-Suhaimi, Julia Altmeier, Said Anajar, Akif Enes Arikan, Irina Azaryan, Lovenish Bains, Giancarlo Basili, Hakan Bolukbasi, Marco Bononi, Farzad Borumandi, Mehmet Buğra Bozan, Gabriela Brenta, Laurent Brunaud, Maximilian Brunner, Antoine Buemi, Gian Luigi Canu, Federico Cappellacci, Sara Burchfield Cartwright, Ignasi Castells Fusté, Beatriz Cavalheiro, Giuseppe Cavallaro, Andres Chala, Shun Yan Bryant Chan, John Chaplin, Mustafa Sajjad Cheema, Costanza Chiapponi, Maria Grazia Chiofalo, Emmanuel Chrysos, Annamaria D'Amore, Michael de Cillia, Carmela De Crea, Nicolò de Manzini, Leandro Luongo de Matos, Loredana De Pasquale, Paolo Del Rio, Marco Stefano Demarchi, Muthuswamy Dhiwakar, Gianluca Donatini, Jose Miguel Dora, Valerio D'Orazi, Viyey Kishore Doulatram Gamgaram, Vitalijus Eismontas, El Hassane Kabiri, Hadj Omar El Malki, Islam Elzahaby, Octavian Enciu, Antoine Eskander, Francesco Feroci, David Figueroa-Bohorquez, Dimitrios Filis, Gorostidi François, Pedro Frías-Fernández, Armando Gamboa-Dominguez, Volkan Genc, Davide Giordano, Antonio Gómez-Pedraza, Giuseppa Graceffa, James Griffin, Sofia Cuco Guerreiro, Karan Gupta, Keshav Kumar Gupta, Angela Gurrado, Jiannis Hajiioannou, Tommi Hakala, Wirsma Arif Harahap, Lindsay Hargitai, Dana Hartl, Andrzej Hellmann, Jiri Hlozek, Van Trung Hoang, Maurizio Iacobone, Nadia Innaro, Orestis Ioannidis, J H Isabelle Jang, Jose Candido Xavier-Junior, Milan Jovanovic, Reto Martin Kaderli, Fahmi Kakamad, Krzysztof Kaliszewski, Martin Karamanliev, Hiroshi Katoh, Andro Košec, Bozidar Kovacevic, Luiz Paulo Kowalski, Robert Králik, Sanjay Kumar Yadav, Adriána Kumorová, Savvas Lampridis, Konstantinos Lasithiotakis, Jean-Christophe Leclere, Eugene Kwong Fei Leong, Melvin Khee-Shing Leow, James Y Lim, Leonardo S Lino-Silva, Shirley Yuk Wah Liu, Núria Perucho Llorach, Celestino Pio Lombardi, Javier López-Gómez, Eleonora Lori, Lourdes Quintanilla-Dieck, Roberta Lucchini, Amin Madani, Dimitrios Manatakis, Ivan Markovic, Gabriele Materazzi, Haggi Mazeh, Giuseppe Mercante, Goswin Yason Meyer-Rochow, Olgica Mihaljevic, Julie A Miller, Michele Minuto, Massimo Monacelli, Francesk Mulita, Barbara Mullineris, José Luis Muñoz-de-Nova, Fábio Muradás Girardi, Saki Nader, Tangjaturonrasme Napadon, Constantinos Nastos, Chiara Offi, Ohad Ronen, Luigi Oragano, Aida Orois, Yongqin Pan, Emmanouil Panagiotidis, Ramakanth Bhargav Panchangam, Theodosios Papavramidis, Pradipta Kumar Parida, Anna Paspala, Òscar Vidal Pérez, Sabrina Petrovic, Marco Raffaelli, Constanza Fernanda Ramacciotti, Tomas Ratia Gimenez, Ángel Rivo Vázquez, Jong-Lyel Roh, Leonardo Rossi, Alvaro Sanabria, Alena Santeerapharp, Arseny Semenov, Sanjeewa Seneviratne, Altinay Serdar, Patrick Sheahan, Sean C Sheppard, Rachel L Slotcavage, Constantin Smaxwil, Soo Young Kim, Salvatore Sorrenti, Eleftherios Spartalis, Chutintorn Sriphrapradang, Mario Testini, Yigit Turk, George Tzikos, Kristina Vabalayte, Kelly Vargas-Osorio, Rafael Sebastián Vázquez Rentería, David Velázquez-Fernández, Sanura Malinda Pallegoda Vithana, Levent Yücel, Erwin Danil Yulian, Petra Zahradnikova, Paul Zarogoulidis, Evgeniia Ziablitskaia, Anna Zolotoukho, Pietro Giorgio Calò, A Abdallah, AL Abentroth, V Acheimastos, M Agunaoun, HM Al Bisher, A Al Ghuzlan, H Alakus, M Alkan, MC Almaraz Almaraz, K Amram, S Anesidis, E Anestiadou, D Angelucci, GL Ansaldo, MI Antonopoulou, M Arciniegas, C Armellin, G Arredondo Saldaña, J Astl, E Athanasakis, S Avenia, H Aydın, B Baba, J Babala, MV Banús, LA Barba-Valadez, SV Barcons, F Battafarano, A Bayat, RMC Bella, F Benariba, S Bernardi, EG Bignami, M Bitenc, S Bitsianis, JDD Bolaños de la Torre, E Bonati, T Bonetti, FA Borges, K Bouchagier, M Boudina, A Bourial, I Breuskin, P Brock, C Bruns, MC Burlacu, T Burton, M Buta, D Buzanakov, C Caliseo, D Callanan, V Calu, JM Cameselle-Teijeiro, DJ Camilo-Junior, S Canberk, V Candalise, F Candanedo-Gonzalez, LJ Carrillo Lizarazo, GB Carvalho, D Casallas, C Casolino, L Castellani, C Castillo Morales, G Chambon, V Chatzipavlidou, R Chernikov, A Chorti, TCM Chow, A Chrisoulidou, E Chrysos, S Conrado-Neto, D Cordova García, A Corigliano, A Crocco, A Cuesta, M Čukman, LS Curto, RA Damilano, R D'Anna, M De, A De Virgilio, D Dellaportas, L Demarquet, A Devresse, G Di Meo, R Diaz Pedrero, D Dimitrov, Z Dmitry, P Domínguez Garijo, O Dulgeroglu, AC Dural, A Eksi, M El Hammoumi, H El Kaoui, G Eleni, A Elliyanti, Ş Ersöz, M Escobar-Jiménez, L Fedorova, L Feeley, E Fernández Rodríguez, F Ferreli, A Filoia, A Fingeret, A Francescato, F Gaino, F Galiandro, JF Gallegos-Hernández, G Garas, F García Lorenzo, JP García-Chávez, M Gaudiello, S Gay, S Gerasimos, M Gerek, R Gervasi, A Giordano, B Gjeloshi, L Gocký, E Golubinskaya, S González Romero, C González-Mínguez, M Goran, A Gosman, M Granados Garcia, E Greco, M Grünbart, R Grützmann, J Guerlain, XG Guirao, D Guzey, A Hajjij, O Hamdy, MS Hameed, LA Hauth, JD Hernández-Acevedo, JF Hernandez-Carrillo, F Hevilla Sánchez, H Hoi, K Hongkwon, R Hu Zhu, E Huang, K Hyeung Kyoo, V Ignjatovic, A Ioannidis, A Iossa, A Işık, D James, L Jung Hoon, H Kara, J Karajovic, D Kartini, D Khambri, I Kholová, M Kisiel, M Knežević, YQ Koh, C Konca, C Kosmidis, G Kotsovolis, LP Kowalski, R Kralik, P Kuczma, BG Kuravi, A Kurnia, V Kyriaki, CM Lai, B Lallemant, AA Lardhi, S Leboulleux, JW Lee, G Lelli, M Leutner, MY Lim, CM Lim, A Llanos, X Lo, T Loderer, MA López-Corrales, M Ludwig, FF Magnabosco, C Maheo, AL Maia, O Makay, P Maksimova, S Mallick, C Mallouk, Z Mamani, S Mandal, M Manyalich Blasi, G Marincola, M Marulanda, M Mavromati, S Mayilvaganan, S Metso, A Micalizzi, A Michalopoulos, K Min-Su, A Miron, AK Mishra, C Misso, C Mittermair, Y Morosán Allo, M Mourad, M Moysidis, F Nabhan, R Nasiri, C Nastos, KY Ngiam, C Nomine-Criqui, AM Ntziovara, JM Nuño Vázquez-Garza, V Nutautiene, K Obtulovičová, L O'Keeffe, NO Okudur, P Ossola, E Ovejero Merino, M Ozdemir, A Pangonis, SS Panigoro, A Panuzi, D Papaconstantinou, N Pardo Matamoros, S Paschou, A Pasculli, K Paterakis, K Peiris, F Pennestrì, M Peppa, P Perdikaris, I Perdikaris, RH Pérez-Soto, S Piana, M Piccoli, D Pietrasanta, G Placentino, I Pliakos, A Polistena, A Pongtippan, G Potard, V Quinn, P Rahul, T Ramos, A Rankin, P Ratnayake, J Reuto-Castillo, A Ridolfo, J Rios-Valencia, P Riss, E Rival, J Rivillas, D Roi, EM Rollo, A Romanchishen, M Romito, J Rotnagl, B Rovcanin, G Russo, M Sabol, S Saki, S Saleh, A Salih, A Saltiki, G Salvador-Camarmo, DK Samal, S Sánchez-Flores, K Sapalidis, D Sarin, H Sarin, N Savkovic, RS Scheffel, AL Scheinpflug, C Scheuba, N Scheyer, M Schmidt, O Senashova, E Serafini, ML Serrano Arévalo, J Shank, ML Shindo, M Shoshkova, M Shvan, M Sičák, TG Silva, O Simó Guerrero, V Skuletic, N Slijepcevic, Z Slovic, P Soares, A Somova, S Soto, S Spiezia, V Stankovic, KJ Stephenson, E Straub, M Summa, S Surani, AA Syed, S Symeonidis, A Taciak, M Tarallo, A Tarle, N Tasis, K Tausanovic, L Tchabashvili, M Thierry, U Tokarczyk, EA Toma, S Topuz, F Torresan, C Uras, C Vaccaro, Á Valdés de Anca, M Valentini, E Varaldo, JG Vartanian, GI Verras, A Vithanage, H Wijayalathge, P Wiriyaamornchai, YLC Wong, P Wongwattana, S Xenaki, S Xie, M Xu, W Yang, S Yilmaz, YF Yılmaz, T Yotsov, MT Zahid, A Zielke, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, and UCL - (SLuc) Service de néphrologie
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Endocrinology ,Endocrinology, Diabetes and Metabolism ,Internal Medicine - Abstract
Since its outbreak in early 2020, the COVID-19 pandemic has diverted resources from non-urgent and elective procedures, leading to diagnosis and treatment delays, with an increased number of neoplasms at advanced stages worldwide. The aims of this study were to quantify the reduction in surgical activity for indeterminate thyroid nodules during the COVID-19 pandemic; and to evaluate whether delays in surgery led to an increased occurrence of aggressive tumours. In this retrospective, international, cross-sectional study, centres were invited to participate in June 22, 2022; each centre joining the study was asked to provide data from medical records on all surgical thyroidectomies consecutively performed from Jan 1, 2019, to Dec 31, 2021. Patients with indeterminate thyroid nodules were divided into three groups according to when they underwent surgery: from Jan 1, 2019, to Feb 29, 2020 (global prepandemic phase), from March 1, 2020, to May 31, 2021 (pandemic escalation phase), and from June 1 to Dec 31, 2021 (pandemic decrease phase). The main outcomes were, for each phase, the number of surgeries for indeterminate thyroid nodules, and in patients with a postoperative diagnosis of thyroid cancers, the occurrence of tumours larger than 10 mm, extrathyroidal extension, lymph node metastases, vascular invasion, distant metastases, and tumours at high risk of structural disease recurrence. Univariate analysis was used to compare the probability of aggressive thyroid features between the first and third study phases. The study was registered on ClinicalTrials.gov, NCT05178186. Data from 157 centres (n=49 countries) on 87 467 patients who underwent surgery for benign and malignant thyroid disease were collected, of whom 22 974 patients (18 052 [78·6%] female patients and 4922 [21·4%] male patients) received surgery for indeterminate thyroid nodules. We observed a significant reduction in surgery for indeterminate thyroid nodules during the pandemic escalation phase (median monthly surgeries per centre, 1·4 [IQR 0·6-3·4]) compared with the prepandemic phase (2·0 [0·9-3·7]; p
- Published
- 2023
3. ENGOT-ov43/keylynk-001: A phase III, placebo- and active-controlled trial of pembrolizumab plus chemotherapy with olaparib maintenance for first-line treatment of advanced BRCA-nonmutated epithelial ovarian cancer
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R.L. Coleman, K. Fujiwara, J. Sehouli, V. Salutari, P. Zola, R. Madry, J. Korach, P. Pautier, D. Cibula, S. Lheureux, K. Hasegawa, B.G. Kim, C.H. Lai, A. Gonzalez-Martinez, Q. Liu, S. Keefe, M. Puglisi, S. Topuz, B.J. Monk, R.C. Arend, D.M. O'Malley, and I. Vergote
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Oncology ,Obstetrics and Gynecology - Published
- 2020
4. ENGOT-ov43/KEYLYNK-001: A phase III trial of pembrolizumab plus chemotherapy with olaparib maintenance for first-line treatment of BRCA¬-nonmutated advanced epithelial ovarian cancer
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A. Gonzalez-Martinez, M Puglisi, Jacob Korach, Stephen Michael Keefe, Keiichi Fujiwara, Vanda Salutari, David Cibula, Ignace Vergote, C.-H. Lai, Qi Liu, Jalid Sehouli, S. Topuz, Radoslaw Madry, Kosei Hasegawa, Robert M. Wenham, Patricia Pautier, Stephanie Lheureux, Byung-Tae Kim, and Paolo Zola
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0301 basic medicine ,Peritoneal cancer ,business.industry ,Advanced stage ,Stock options ,Hematology ,Management ,First line treatment ,03 medical and health sciences ,Stratification Factor ,030104 developmental biology ,0302 clinical medicine ,Oncology ,030220 oncology & carcinogenesis ,Medicine ,In patient ,Epithelial ovarian cancer ,business ,After treatment - Abstract
Background Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer and is often diagnosed at advanced stages. The current standard of care (SOC) for advanced EOC is primary debulking surgery (PDS) followed by adjuvant carboplatin/paclitaxel chemotherapy (CT). Although SOC may be effective initially, most patients experience relapse within 3 years after treatment. Combination therapy with PD-1 inhibitor pembrolizumab (pembro) plus PARP inhibitor niraparib resulted in efficacy in patients with platinum-resistant, relapsed OC in the phase 1/2 study TOPACIO/KEYNOTE-162. The PARP inhibitor olaparib is approved for women with newly diagnosed BRCA-mutated OC, as well as for platinum-sensitive, recurrent OC regardless of BRCA1/2 status. Pembro plus CT followed by olaparib maintenance therapy is being investigated in ENGOT-ov43/KEYLYNK-001 (NCT03740165), a phase 3, randomized, double-blind, active- and placebo-controlled study for first-line treatment of women with BRCA1/2-nonmutated advanced EOC. Trial design Women with stage III or IV BRCA-nonmutated EOC, primary peritoneal cancer, or fallopian tube cancer will be randomized 1:1:1 after one lead-in cycle of CT to receive pembro + CT followed by olaparib maintenance; pembro + CT followed by placebo; or placebo + CT followed by placebo. Stratification factors include surgery status (residual tumor after PDS [yes/no] or planned interval debulking), planned bevacizumab use (yes/no), and PD-L1 combined positive score (CPS; Clinical trial identification NCT03740165. Legal entity responsible for the study Merck & Co., Inc. Funding Funding for this study was provided by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA. Disclosure K. Fujiwara: Advisory / Consultancy, Research grant / Funding (institution): AstraZeneca; Honoraria (self), Advisory / Consultancy, Research grant / Funding (institution): Chugai Pharma; Honoraria (self), Advisory / Consultancy, Research grant / Funding (institution): Eisai; Advisory / Consultancy, Research grant / Funding (institution): Merck Sharpe & Dohme Corp.; Advisory / Consultancy, Research grant / Funding (institution): Pfizer; Honoraria (self), Advisory / Consultancy, Research grant / Funding (institution): Taiho Pharmaceutical; Advisory / Consultancy: Takeda; Honoraria (self): Bayer; Honoraria (self): Daiichi Sankyo; Honoraria (self): Janssen Oncology; Honoraria (self): Kyowa Hakko Kirin; Honoraria (self), Research grant / Funding (institution): Lilly Japan; Honoraria (self): Nippon Kayaku; Honoraria (self), Research grant / Funding (institution): Ono Pharmaceutical; Honoraria (self): Zeria Pharmaceutical; Research grant / Funding (institution): GlaxoSmithKline; Research grant / Funding (institution): Immunogen; Research grant / Funding (institution): Kaken Pharmaceutical; Research grant / Funding (institution): Oncotherapeutics; Research grant / Funding (institution): Shionogi. I.B. Vergote: Advisory / Consultancy, Travel / Accommodation / Expenses: AstraZeneca; Advisory / Consultancy: Eisai; Advisory / Consultancy, Travel / Accommodation / Expenses: PharmaMar; Advisory / Consultancy, Research grant / Funding (institution), Travel / Accommodation / Expenses: Roche; Advisory / Consultancy: Advaxis; Advisory / Consultancy: Merck Sharp & Dohme Corp.; Advisory / Consultancy, Research grant / Funding (institution), Travel / Accommodation / Expenses: Genmab; Advisory / Consultancy: Millennium Pharmaceuticals; Advisory / Consultancy: Clovis Oncology; Advisory / Consultancy: Immunogen; Advisory / Consultancy, Travel / Accommodation / Expenses: TESARO, Inc.; Advisory / Consultancy, Research grant / Funding (institution): Oncoinvent; Advisory / Consultancy: Roche; Advisory / Consultancy: Sotio; Travel / Accommodation / Expenses: Takeda; Research grant / Funding (institution): Amgen. J. Sehouli: Honoraria (self), Advisory / Consultancy, Travel / Accommodation / Expenses: AstraZeneca; Honoraria (self): Eisai; Honoraria (self), Advisory / Consultancy, Travel / Accommodation / Expenses: Clovis; Honoraria (self): Olympus; Honoraria (self): JohnsonJ Honoraria (self), Advisory / Consultancy, Travel / Accommodation / Expenses: Pfizer; Honoraria (self), Advisory / Consultancy, Travel / Accommodation / Expenses: PharmaMar; Honoraria (self): Teva Pharmaceutical Industries Ltd.; Honoraria (self), Advisory / Consultancy, Travel / Accommodation / Expenses: TESARO, Inc.; Honoraria (self), Advisory / Consultancy, Travel / Accommodation / Expenses: Merck Sharpe & Dohme Corp.; Advisory / Consultancy: Lilly; Advisory / Consultancy, Travel / Accommodation / Expenses: Roche. P. Zola: Advisory / Consultancy, Travel / Accommodation / Expenses: TESARO, Inc.; Advisory / Consultancy, Research grant / Funding (self), Travel / Accommodation / Expenses: AstraZeneca; Advisory / Consultancy, Research grant / Funding (self): Roche. R.M. Wenham: Research grant / Funding (self), Shareholder / Stockholder / Stock options: Ovation Diagnostics; Advisory / Consultancy, Speaker Bureau / Expert testimony: TESARO, Inc.; Advisory / Consultancy: Merck; Advisory / Consultancy, Speaker Bureau / Expert testimony: Clovis; Advisory / Consultancy, Speaker Bureau / Expert testimony: Genentech; Advisory / Consultancy: Mersana Therapeutics; Research grant / Funding (self): TapImmune; Research grant / Funding (self): Merck; Research grant / Funding (self): Prescient Therapeutics. P. Pautier: Advisory / Consultancy: Roche; Advisory / Consultancy, Travel / Accommodation / Expenses: PharmaMar; Advisory / Consultancy: GlaxoSmithKline. S. Lheureux: Advisory / Consultancy, Research grant / Funding (institution): AstraZeneca; Research grant / Funding (institution): TESARO, Inc.; Research grant / Funding (institution): Roche/Genentech; Research grant / Funding (institution): Regeneron. K. Hasegawa: Honoraria (self), Research grant / Funding (self): Daiichi-Sankyo; Honoraria (self): Chugai; Honoraria (self), Advisory / Consultancy: Merck Sharpe & Dohme Corp.; Honoraria (self): AstraZeneca; Research grant / Funding (self): Yakult Honsha; Research grant / Funding (self): Pfizer. C-H. Lai: Research grant / Funding (self): Roche; Research grant / Funding (self): TTY Biopharm. A. Gonzalez-Martinez: Advisory / Consultancy, Speaker Bureau / Expert testimony, Research grant / Funding (institution): Roche; Advisory / Consultancy, Speaker Bureau / Expert testimony: AstraZeneca; Advisory / Consultancy: Clovis; Advisory / Consultancy: Pfizer; Advisory / Consultancy: Merck Sharpe & Dohme Corp.; Advisory / Consultancy, Speaker Bureau / Expert testimony, Research grant / Funding (institution): TESARO, Inc.; Advisory / Consultancy, Speaker Bureau / Expert testimony: Pharmama. Q. Liu: Shareholder / Stockholder / Stock options, Full / Part-time employment: Merck & Co., Inc. S.M. Keefe: Travel / Accommodation / Expenses, Shareholder / Stockholder / Stock options, Full / Part-time employment: Merck & Co., Inc. M. Puglisi: Shareholder / Stockholder / Stock options, Full / Part-time employment: Merck & Co., Inc. All other authors have declared no conflicts of interest.
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- 2019
5. THU0529 The comparison of physical activity level in pregnant women with and without low back pain
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Ceren Orhan, Türkan Akbayrak, S. Topuz, Sinan Beksaç, Esra Üzelpasaci, Gülbala Nakip, Emine Baran, and Serap Özgül
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030203 arthritis & rheumatology ,medicine.medical_specialty ,Pregnancy ,business.industry ,medicine.disease ,Low back pain ,Physical activity level ,03 medical and health sciences ,0302 clinical medicine ,Lumbar ,Quality of life ,Physical therapy ,medicine ,Gestation ,Observational study ,medicine.symptom ,business ,Body mass index ,030217 neurology & neurosurgery - Abstract
Background Low back pain (LBP) is one of the most common musculoskeletal problems during pregnancy that occurs due to a combination of mechanical, hormonal, circulatory and psychological factors. The changes in the load, body mechanics and centre of gravity, increased levels of relaxin, and decreased venous circulation in the pelvic and lumbar region may contribute to LBP in pregnant women.1,2 It has been reported that the prevalence of LBP ranges between 50% and 80%. Pregnant women suffer from LBP may experience significant physical, psychological and social problems which adversely affect their quality of life.3 Objectives The aim of the study was to compare the physical activity level of pregnant women with and without LBP. Methods A total of 151 pregnant women without obstetric and medical complications were included in this study. Sociodemographic and obstetric characteristics of the participants were assessed with a standart questionnaire. The presence of LBP was recorded as “yes” and “no”. The level of physical activity was assessed with the Pregnancy Physical Activity Questionnaire (PPAQ). The PPAQ is self-administered and asks respondents to report the time spent participating in 32 activities including household/caregiving, occupational, sports/exercise, transportation and inactivity. Independent samples t test was used to determine whether there was a difference in physical activity level between two independent groups (Group 1: Pregnant women with LBP, Group 2: Pregnant women without LBP). Results 77 pregnant women (mean age: 29.28±5.14 years, mean body mass index (BMI): 25.95±3.86 kg/m2) had no LBP. However, 74 pregnant women (mean age: 29.22±4.90 years, BMI: 26.85±2.78 kg/m2) have experienced LBP. There was no statistically significant difference in gestational week between two groups (p>0.05). Exercise-sports activity (mean: 5.69±7.29 MET–h.week-1) and vigorous activity (mean: 2.39±3.80 MET–h.week-1) scores of PPAQ were significantly lower in the pregnants with LBP than in those without LBP. Other activity scores were similar between groups (p>0.05). Conclusions The presence of LBP during pregnancy causes decreased levels of sports and exercise activities in the pregnant women while household/caregiving and occupational activities are being carried out. LBP can be a barrier to perform physical activities and exercises for pregnant women. Therefore, it should be treated with appropriate methods and pregnant women should be encouraged to regularly participate to exercise programs. References [1] Ryan, Cormac G, et al. Individuals with chronic low back pain have a lower level, and an altered pattern, of physical activity compared with matched controls: an observational study. Australian Journal of Physiotherapy2009; 55(1): 53–58. [2] Katonis P, et al. Pregnancy-related low back pain. Hippokratia2011;15(3):205. [3] Lima ACDN, Oliveira FBD, Avolio GP, Silva GDD, et al. Prevalence of low back pain and interference with quality of life of pregnant women. Revista Dor2017;18(2):119–123. Acknowledgements None. Disclosure of Interest None declared
- Published
- 2018
6. General gynecology
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A. Salfelder, R. P. Lueken, C. Bormann, A. Gallinat, C. P. Moeller, D. Busche, W. Nugent, E. Krueger, A. Nugent, G. Caglar, Y. Tasci, F. Kayikcioglu, A. Haberal, Th. Hasskamp, M. Krichbaum, N. Aka, G. Köse, G. Sabah, E. S. Sayharman, P. Kumru, K. Karaca, B. Haydardedeoglu, E. Simsek, E. Kilicdag, E. Tarim, T. Bagis, F. S. Dede, B. Dilbaz, H. Dede, A. K. Ilhan, S. Oral, A. Erten, I. E. Ertas, S. Kahyaoglu, I. Turgay, M. Tug, S. Kalyoncu, S. Batioglu, G. Zorlu, C. Arici, M. E. Akar, E. S. Ari, E. Ari, O. U. Erbay, M. O. Caliskan, M. Simsek, O. Taskm, Il. Gümüs, N. O. Turhan, G. Arikan, A. Giuliani, S. Kelekci, Z. Yorgancioglu, B. Yilmaz, L. Yasar, K. Savan, S. Sonmez, C. Kart, M. Vural, H. A. Tanriverdi, E. Cinar, A. Barut, K. Özbay, T. Yardim, B. Demir, N. Kilinc, T. Gul, A. C. Erden, M. K. Kokanali, E. B. Kilicdag, E. Aslan, M. Seval, S. Taskin, B. Özmen, K. Kahraman, A. Yarci, T. Tasci, C. Unlü, M. Gözükücük, S. Kurt, E. A. Bozaci, F. Ortac, A. S. Sönmez, A. G. Zebitay, N. Gezer, H. F. Yazicioglu, G. Mehmetoglu, M. Kocak, Y. L. Algül, J. Ozcan, O. Duman, F. Yazicioglu, Y. Sensoy, S. Koc, Z. Cebi, J. Özcan, S. Sönmez, I. Mendilcioglu, M. Özekinci, M. Ulukus, E. C. Ulukus, Y. Seval, O. Cinar, W. Zheng, A. Arici, L. Erkan, F. Soylu, O. Tatli, V. Ozkent, A. R. Dogan, I. Gün, E. Erdemoglu, H. Sargin, M. Kamaci, F. Sendag, L. Akman, S. Yucebilgin, N. Karadadas, K. Oztekin, O. Bilgin, S. Topuz, E. Cigerli, C. A. Iyibozkurt, E. S. Akhan, H. Saygili, S. Berkman, I. Bezircioglu, E. Karakaya, N. Baran, A. Baloglu, C. Aydin, N. Hizli, B. Cetinkaya, A. Kavas, K. Cukurova, A. Köksal, H. Yetimalar, A. Yildiz, H. Ivit, A. Keklik, F. Pinar, N. Tosun, T. Tuncel, K. Boynukalin, M. C. Salman, O. Ozyuncu, G. Bozdag, A. Ayhan, U. Ates, T. Usta, A. Seyhan, B. Ata, B. Sidal, O. T. Guler, S. Esin, S. Guven, A. Gürban, G. Gürban, S. Özen, A. Kirecci, B. Özkesici, S. Yücel, N. Süer, C. E. Erdemoglu, S. E. Akhan, I. Citil, C. Iyibozkurt, M. D. Kesim, A. Atis, Y. Aydin, D. Özpak, F. Tashan, S. Zeteroglu, A. Kolusari, H. Altunay, H. G. Sahin, O. Erol, S. Sarici, B. S. Dingiloglu, T. Güngör, B. Özdal, S. Cavkaytar, Ü. Bilge, L. Mollamahmutoglu, Konca M. Toprak, S. Özsoy, N. Hekim, E. Özel, M. Senates, C. Yener, N. Göker, E. Caliskan, T. Filiz, G. Yucesoy, E. Coskun, B. Vural, A. Corakci, M. A. Narin, M. M. Meydanli, B. Yildizbas, G. Bolluk, B. Ozdemir, B. S. Ünlü, H. Aytan, S. Evsen, Ö L. Tapisiz, S. Zergeroglu, A. Guler, M. M. Altay, A. Can, A. Ungormus, and A. Polat
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Obstetrics and Gynecology ,General Medicine - Published
- 2005
7. Gynecologic oncology
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G. Oskav-Özcelik, H. J. Hindenburg, P. Klare, D. Könsgen, A. Mustea, G. Heinrich, O. Camara, W. Lichtenegger, J. Sehouli, L. Tutuncu, A. R. Ergur, I. Gul, A. Ertekin, Y. Z. Yergok, T. Ornek, G. Tulunay, A. Fetiel, O. Tan, F. Kose, A. Haberal, F. Noftolin, E. Yermez, N. Ata, M. Sanci, I. Sekü, C. Karanfil, C. Ispahi, M. E. Akar, T. Simsek, E. Tamburaci, G. Erdogan, E. Pestereli, M. Ingec, S. Kadanali, F. Erdogan, M. M. Naki, C. Tekcan, Y. S. Ergüler, A. Uysal, S. Songülalp, F. Kanadikirik, K. Gezginc, H. Görkemli, C. Celik, A. Acar, M. C. Colakoglu, M. Capar, C. Akyürek, K. Özbay, T. Yardim, S. Kurt, B. Pilanci, S. Tinar, H. Camuzcuoglu, N. Dicle, M. Hanhan, M. Inal, D. Öztekin, Z. Özsaran, B. Demir, S. Demir, T. Gul, A. C. Erden, E. A. Bozaci, C. Atabekoglu, S. Taskin, A. Sertcelik, C. Ünlü, F. Ortac, B. Cengiz, M. Seval, A. Yarci, K. Kahraman, B. Özmen, M. Güngör, S. Hascalik, O. Celik, Y. Ustun, G. Erdem, N. Karadag, A. Alkan, H. M. Karakas, U. Usta, B. Mizrak, K. Güzin, Eser S. Kayatas, E. Zemheri, O. Karalti, G. Gunaydin, A. Onan, C. Taskiran, A. Turp, E. Yilmaz, M. Kurdoglu, G. Bozdayi, O. Himmetoglu, Z. Kurdoglu, M. Gultekin, P. Dursun, N. Y. Celik, K. Boynukalin, K. Yuce, A. Ayhan, M. Velipasaoglu, G. Bozdag, Z. Guler, L. Erkan, F. Soylu, O. Oztekin, O. Tatli, T. Eraslan, D. Uysal, A. Yavuzcan, U. Yensel, A. Baloglu, A. Yildiz, A. Köksal, Ö. Tatli, H. Ivit, H. Yetimalar, K. Cukurova, E. Simsek, B. Haydardedeoglu, E. Asian, Kilicdag E. Bulgan, S. Erkanli, Tarim E. Ozyurtseven, S. Kayatas, F. Kayabasoglu, C. Aydin, M. C. Salman, U. Otegen, O. Ozyuncu, S. Guven, A. Usubutun, D. Oztekin, T. Mit, D. Balsak, S. Seyhan, T. Turan, S. Altinbas, N. Boran, N. Ozgul, S. Ozer, A. Ozfuttu, M. F. Kose, D. Hizli, F. Halici, S. Koc, D. Bulbul, M. F. Köse, M. Vural, A. Barut, H. A. Tanriverdi, M. Sancaktar, A. C. Iyibozkurt, S. Topuz, E. Bengisu, R. Ilhan, S. Berkman, S. Sarici, R. Ocalan, D. Cavusoglu, Ö. Karacay, E. Öztürkoglu, A. Cil, O. F. Otken, F. Öztürk, N. Özgül, Z. Erdogan, H. Otken, K. Yüksel, B. Özdal, T. Güngör, D. Taner, I. Tarhan, H. Reyhan, T. Aydogdu, L. Mollamahmutoglu, B. H. Daylan, S. Zergeroglu, I. Tunc, N. Kahraman, T. Gungor, U. Bilge, H. Aytan, M. T. Tug, M. Tug, S. Cavkaytar, H. B. Daylan, I. Tune, Ö. Koc, S. Gözübüyük, S. Seckin, T. Özdemir, R. Abali, S. Bozkurt, I. Arikan, D. Arikan, A. Sahin, O. Erdener, Ö. Tülay, S. Ergin, K. Midilli, A. Fatial, J. Luk, F. Neftolin, E. Aslan, E. Kilicdag, F. Bolat, N. Bal, E. Kuscu, A. Ayar, Y. Güzel, M. H. Yetimalar, U. Zeteroglu, and S. Zeteroglu
- Subjects
Obstetrics and Gynecology ,General Medicine - Published
- 2005
8. Factors affecting recurrence and disease-free survival in granulosa cell tumors of the ovary
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A C, Iyibozkurt, S, Topuz, F, Gungor, S E, Akhan, F, Demirci, Y, Salihoglu, S, Berkman, and E, Bengisu
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Adult ,Ovarian Neoplasms ,Turkey ,Liver Neoplasms ,Age Factors ,Middle Aged ,Prognosis ,Young Adult ,Recurrence ,Risk Factors ,Disease Progression ,Humans ,Women's Health ,Female ,Neoplasm Metastasis ,Follow-Up Studies ,Granulosa Cell Tumor ,Pelvic Neoplasms ,Retrospective Studies - Abstract
To determine risk factors for prognosis and recurrence in ovarian adult-type granulosa cell tumor (GCT).A retrospective review of GCT cases treated at our university hospital between 1991-2006.Of 39 patients with GCT, 82% had Stage I disease. The median follow-up period was 71 months. There were 12 cases of recurrence (30.8%) and seven of them had died of disease. The pelvis and liver were the most common sites of recurrence (8 and 3 patients, respectively). Interestingly lymph node recurrence was encountered in two patients. Estimated disease-free survival for five years was 82%. Stage and presence of residual tumor were calculated to be the only associated risk factors for recurrence and prognosis (p0.05).Recurrences in GCT might be associated with stage and presence of residual tumor during primary surgery. Although rarely present during diagnosis, lymph node metastasis might be more common in recurrent disease.
- Published
- 2011
9. Groin recurrence following stage IA squamous cell carcinoma of the vulva with negative nodes on superficial inguinal lymphadenectomy
- Author
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A C, Iyibozkurt, O C, Dural, S, Topuz, S, Berkman, and E, Bengisu
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Vulvar Neoplasms ,Lymphatic Metastasis ,Carcinoma, Squamous Cell ,Humans ,Lymph Node Excision ,Female ,Middle Aged ,Neoplasm Recurrence, Local ,Groin ,Neoplasm Staging - Abstract
Stage IA vulvar cancer with a depth of stromal invasion less than 1 mm is generally managed by wide local excision alone since there is less than 1% risk of lymph node involvement.A 62-year-old patient was admitted to a university hospital with a suspicious vulvar lesion.We present the first case of inguinal node and a possible contralateral pubic ramus recurrence following bilateral superficial inguinal lymphadenectomy and wide local resection for Stage 1A vulvar cancer.There is no evidence that extended radical surgery provides a better overall survival or reduces recurrence rate in Stage 1A vulvar carcinomas. Conservative vulvar resection and sentinel node dissection seem to be a rational choice. Nevertheless the disease may recur in the inguinal areas and frequently be lethal, therefore close surveillance and early attempts to treat the recurrent disease before infection and inflammation ensues should be the aim of current treatment strategies.
- Published
- 2010
10. Optimization of public bus transport in Istanbul
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M. Ergun, N. Caliskan, and S. Topuz Kiremitci
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Backbone network ,Engineering ,business.industry ,media_common.quotation_subject ,Discount points ,Visualization ,Task (project management) ,Transport engineering ,Public transport ,Quality (business) ,Mode choice ,business ,media_common ,Network model - Abstract
This paper will discuss how Istanbul’s public transport is very complex with many interactions between different modes of transportation, carriers and new projects. All of them had to be considered in this project, with the knowledge that the optimization had to be focused on the public bus transport provided by the IETT Company. Due to the lack of available basic demand data for private busses, only scheduled services can be considered and not passenger requested services. For public bus transport (mainly company busses), the demand data was gathered from counting data and the Intelligent Ticketing System (Akbil) data. This is the central basic data of the project. Additionally the data for bus, railway, light railway and seaway transportation were handed over and adapted to build up the digital public transport model. After the detailed analysis of the network model and its visualization and reporting features, the weak points of the existing network were found (e.g. parts with low capacity usage of vehicles). Beside the very time intense development of the public transport model, the finding of adequate solutions and proposals for the amelioration of the actual situation was a main task of this project. Different general modes of optimization were found, described and defined in close adjustment with the IETT Company. The study shows the positive effects that can be achieved by different kinds of optimization. Further on, it gives practical examples for the different kinds of optimization and shows the results from the IETT Company – and passenger – point of view. Some improvements are suggested for a more efficient public bus system. Finally, the numbers of the maximum possible savings for the complete region of Istanbul without cutting down the quality of transportation for passengers are given. With the realization of the suggested improvements for the IETT Company bus traffic, the IETT Company can save a lot of money. The passengers will find faster bus lines and reduced travel times; however, the number of transfers between lines will increase. With the supposed acceleration of bus transportation on the future backbone network, there will be a flexible, high quality and reliable bus transportation system for Istanbul to face the challenges of the future.
- Published
- 2009
11. Conservative management of a patient with endometrial carcinoma desiring fertility: how to inform?
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S, Topuz, I, Kalelioğlu, C, Iyibozkurt, and B, Ergun
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Adult ,Fertility ,Antineoplastic Agents, Hormonal ,Pregnancy ,Megestrol Acetate ,Humans ,Female ,Patient Participation ,Carcinoma, Endometrioid ,Endometrial Neoplasms - Abstract
Conservative management of patients with endometrial cancer who desire fertility is becoming widespread in certain circumstances. A 36-year-old women desiring fertility with early-stage endometroid type adenocarcinoma of the endometrium was treated with 160 mg/d megestrol acetate for six months. After confirmation of a normal endometrial biopsy she became pregnant spontaneously. Following an uneventful pregnancy a healthy baby at term was delivered by cesarean section. Definitive surgery was performed. The risks and benefits of this thereupeutic approach are discussed and informing style of the patients emphasized.
- Published
- 2009
12. Malignant germ cell tumors of the ovary: a review of 41 cases and risk factors for recurrence
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S, Topuz, A Cem, Iyibozkurt, S Engin, Akhan, N, Keskin, E, Yavuz, Y, Salihoglu, E, Bengisu, and S, Berkman
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Adult ,Ovarian Neoplasms ,Adolescent ,Dysgerminoma ,Middle Aged ,Neoplasms, Germ Cell and Embryonal ,Cohort Studies ,Young Adult ,Risk Factors ,Humans ,Female ,Neoplasm Recurrence, Local ,Child ,Aged ,Neoplasm Staging ,Retrospective Studies - Abstract
To review the outcome of treatment in patients with malignant ovarian germ cell tumors and to define the risk factors for recurrence.Forty-one patients with malignant ovarian germ cell tumors were reviewed retrospectively. Survival time and survival rate were obtained. Risk factors such as stage, histological type, and type of operation were evaluated for reccurrence.Twenty-three (56%) had dysgerminomas, eight (19.5%) had mixed germ cell tumors, three (7.3%) had yolk sac tumors, three (7.3%) had immature teratomas, two (4.8%) had squamous cell carcinoma arising from a mature teratoma, one (2.4%) had embryonal carcinoma and one choriocarcinoma. Most of the cases (73%) were in Stage I. Twenty-nine patients (70.7%) underwent conservative surgery and 12 patients (29.3%) had at least bilateral salpingo-oophorectomy. Thirty patients were operated on optimally with surgical staging and 11 suboptimally. Seven patients (17%) had recurrence after remission. The overall survival time was 187 +/- 8.43 months for all cases, 195 +/- 8.49 for dysgerminoma and 161 +/- 10.96 for non-dysgerminoma cases with a median follow-up time of 98.52 (8-204) months. Non-dysgerminoma histologic type, being operated on suboptimally and radically, and advanced tumor stage have been found to be risk factors for recurrence.Regardless of histologic types and stages the prognosis of germ cell tumors are satisfactory with current therapeutic strategies.
- Published
- 2009
13. Life-saving hysterectomy in choriocarcinoma: presentation of two cases
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S, Topuz, C, Iyibozkurt, O, Mete, S, Akhan, Y, Salihoğlu, E, Bengisu, and S, Berkman
- Subjects
Adult ,Uterine Neoplasms ,Humans ,Female ,Choriocarcinoma ,Uterine Hemorrhage ,Middle Aged ,Hysterectomy - Abstract
Choriocarcinoma is a malignant tumor of the placenta. Life-saving hysterectomy was performed in two cases with choriocarcinoma who had profuse vaginal bleeding. CASE 1: A 25-year-old, gravida 3, para 1, woman was referred to our emergency clinic with the diagnosis of choriocarcinoma and massive vaginal bleeding. She had been transfused seven units of blood at the hospital where she was first admitted. Pelvic examination demonstrated heavy vaginal bleeding and a uterus equivalent to the size of 14 weeks of gestation. Her beta-hCG level was 560,000 mIU/ml. Despite four units of blood transfusion, she had a pulse rate of 130/min, arterial pressure of 90/60 mm/Hg and HCT of 19%. An emergency hysterectomy with vertical incision was performed. CASE 2: A 54-year-old, gravida 3, para 3, woman was referred to our clinic with heavy bleeding with the diagnosis of choriocarcinoma. She was scanned to look for possible metastases and pulmonary metastasis was detected. Chemotherapy was planned but as sudden vaginal bleeding began she was referred to the Gynecology Department. At pelvic examination a soft uterus the size of 20 weeks of gestation was palpated. The beta-hCG level was 554,700 mIU/ml. Due to hemodynamic instability and continuous vaginal bleeding an emergency hysterectomy was performed.Although chemotherapy is the cornerstone of treatment for choriocarcinoma, optimal treatment results may depend on the addition of surgery in selected circumstances. Hysterectomy is indicated in cases with life-threatening hemorrhage.
- Published
- 2009
14. Invasive squamous carcinoma of the vulva in women aged less than 40 years: report of two cases and a third case diagnosed during pregnancy
- Author
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N, Keskin, A C, Iyibozkurt, S, Topuz, Y, Salihoğlu, E, Bengisu, and S, Berkman
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Adult ,Vulvar Neoplasms ,Pregnancy ,Biopsy ,Carcinoma, Squamous Cell ,Humans ,Female ,Neoplasm Invasiveness ,Pregnancy Complications, Neoplastic ,Medical Records ,Retrospective Studies - Abstract
Invasive squamous cell cancer of the vulva (ISCC) is a rare disease in young patients and in pregnant women. The purpose of this paper was to investigate this type of cancer in women less than 40 years old and to present three cases, one which was diagnosed in the third trimester of pregnancy.Three cases of invasive squamous cell cancer in women under age 40 among the retrospectively analyzed 52 vulvar cancer cases diagnosed between 1995-2002 were investigated.Women aged 25, 39 and 31, respectively, had Stage 1, 2 and 3 ISCC of the vulva. The first two cases had been spared by surgery and radiotherapy. The third patient was diagnosed during the last trimester of pregnancy. Although she was treated by radical surgery and postoperative radiotherapy, she had a recurrence in the inguinal region at 36 months, and died of disease 12 months later.Vulvar ISCC in young women may occur in association with or without predisposing factors. Although HPV-related type is predominant in the literature, keratinizing type of carcinoma may also be seen in this group of patients. Biopsy from suspected lesions is of paramount importance.
- Published
- 2008
15. Pelvic actinomycosis mimicking ovarian malignancy: three cases
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S E, Akhan, Y, Dogan, S, Akhan, A C, Iyibozkurt, S, Topuz, and O, Yalcin
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Adult ,Diagnosis, Differential ,Ovarian Neoplasms ,Actinomyces ,Humans ,Female ,Ovarian Diseases ,Middle Aged ,Actinomycosis ,Intrauterine Devices ,Pelvic Inflammatory Disease ,Pelvis - Abstract
Three cases of pelvic actinomycosis initially diagnosed as pelvic malignancy and treated surgically are reported.The first case was a 38-year-old multiparous woman who was referred to our clinic because of bilateral ovarian solid masses. With the impression of ovarian carcinoma, a laparotomy was performed. During surgery adhesiolysis, total abdominal hysterectomy, bilateral salpingo-oophorectomy, infracolic omentectomy, appendectomy, peritoneal washings, and peritoneal abscess drainage were performed. The second patient was a 37-year-old woman who presented with a left-sided fixed solid mass highly suggestive of pelvic malignancy. Both ureters were found to be dilated with hydronephrosis in the right kidney supporting the diagnosis of retroperitoneal fibrosis. Excision of the mass, colectomy and temporary diverting colostomy and stent insertion to the left ureter were performed. Colostomy repair was performed five months later. On the fifth day postoperatively, fascial necrosis developed so a Bogota-bag was placed on the anterior abdominal wall and left for secondary healing. The third patient was a 51-year-old postmenopausal woman incidentally diagnosed as having a pelvic mass while having been investigated for constipation and nausea. She had had a colostomy one year before and a reanastomosis two months after. Total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed. In all cases, histopathologic staining of the specimens revealed chronic inflammation containing actinomycosis abscesses confirmed with microbiologic identification.Pelvic actinomycosis is an uncommon cause of a pelvic mass. However, it should be kept in mind in the differential diagnosis of pelvic masses, especially in the patients with a history of IUD use to avoid an unnecessary extensive surgical procedure.
- Published
- 2008
16. Conservative treatment of an early ectopic pregnancy in a cesarean scar with systemic methotrexate--case report
- Author
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A C, Iyibozkurt, S, Topuz, F, Gungor, I H, Kalelioglu, E, Cigerli, and S E, Akhan
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Adult ,Abortifacient Agents, Nonsteroidal ,Endometrium ,Methotrexate ,Cesarean Section ,Pregnancy ,Pregnancy, Abdominal ,Humans ,Female ,Injections, Intramuscular ,Ultrasonography - Abstract
Pregnancy implanted in a cesarean scar is rare, and is a life-threatening condition due to high risk of uterine rupture, hemorrhage, hysterectomy, and maternal mortality.We describe a 26-year-old woman who presented with five weeks of amenorrhea and a serum hCG level of 10,440 mIU/ml. Transvaginal sonography revealed a gestational sac of 15 x 11 mm containing a yolk sac located in a previous cesarean scar. She was successfully treated conservatively with multi-dose methotrexate. No side-effects were encountered. The serum hCG levels were undetectable in 58 days. The patient had normal menstrual cycles afterwards.In the view of increasing cesarean rates, healthcare professionals should be aware of the possibility of a scar pregnancy and the potentially life threatening sequelae. Early diagnosis by transvaginal sonography can improve outcome and minimize the need for emergent surgery. Conservative treatment with systemic methotrexate is an effective option in selected patients.
- Published
- 2008
17. Analysis of vaginal recurrences in stage I endometrial adenocarcinoma
- Author
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Y, Salihoğlu, N, Keskin, S, Topuz, S, Küçücük, and C, Iyibozkurt
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Cohort Studies ,Vagina ,Carcinoma, Squamous Cell ,Myometrium ,Humans ,Female ,Neoplasm Invasiveness ,Neoplasm Recurrence, Local ,Survival Analysis ,Adenocarcinoma, Clear Cell ,Endometrial Neoplasms ,Neoplasm Staging - Abstract
To determine the risk of vaginal recurrence in Stage 1 endometrial cancer and treatment morbidity associated with different therapeutic approachesBetween 1995 and 2005, 341 patients with clinical Stage I endometrial cancer were treated at Istanbul Medical Faculty. One hundred and forty-four women were included in this study as the follow-ups and records were complete. The patients with no myometrial invasion received no further therapy following hysterectomy. When there was superficial myometrial invasion postoperative vaginal vault radiation was used, and if deep myometrial invasion was present, external pelvic radiation was given.Overall 5-year survival rate for all patients with Stage I disease was 80%. Nine patients (6.25%) developed recurrent disease, three of whom had vaginal recurrences. All three vaginal recurrences were small and diagnosed at routine follow-up exam within 51 months of primary therapy.This selective treatment protocol for patients with Stage I endometrial cancer avoided radiation entirely in 38% of the patients while achieving a very low rate of vaginal recurrence and good overall survival.
- Published
- 2007
18. Differentiation of benign and malignant adnexal masses: value of a morphologic scoring system
- Author
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S, Topuz, H, Saygili, S, Akhan, E, Yavuz, A, Turfanda, and S, Berkman
- Subjects
Adult ,Aged, 80 and over ,Diagnosis, Differential ,Adolescent ,Predictive Value of Tests ,Adnexal Diseases ,Neoplasms ,Humans ,Female ,Prospective Studies ,Middle Aged ,Aged ,Ultrasonography - Abstract
The purpose of this study was to assess the value of conventional gray-scale ultrasonography, based on a morphologic scoring system, in the differential diagnosis of malignant and benign adnexal tumors.A total of 58 adnexal masses in 51 patients were classified prospectively as suggestive of malignant or benign, on the basis of gray-scale ultrasonographic morphology. The results were correlated with histopathological diagnosis.Histopathology of 42 masses was found to be benign and 16 masses were found to be malignant. On gray-scale analysis 15 of 16 malignant masses were classified as suggestive of malignant and 37 of 42 benign masses were classified as suggestive of benign. The sensitivity, specificity, positive predictive value and negative predictive value are calculated as 93%, 88%, 75%, and 97%, respectively.Prediction of malignancy using gray scale ultrasonograhy based on a morphological scoring system was reliable (NPV = 97%, PPV = 93%). However further investigations about the assessment of adnexal masses with ultrasonography are needed
- Published
- 2005
19. Laparoscopic evaluation of metastatic ovarian cancer: a case report
- Author
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A C, Iyibozkurt, S E, Akhan, S, Topuz, I, Citil, and S, Berkman
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Adult ,Diagnosis, Differential ,Ovarian Neoplasms ,Laparotomy ,Stomach Neoplasms ,Humans ,Female ,Neoplasm Metastasis ,Carcinoma, Signet Ring Cell ,Magnetic Resonance Imaging - Abstract
OBJECTIVE AND CASE: Both noninvasive and invasive methods have limited value in the diagnosis of metastatic ovarian cancer. We present a case with the initial complaint of abdominal distention in whom primary and metastatic tumor sites were safely diagnosed by using laparoscopy: a gastric tumor with ovarian metastasis.Diagnostic laparoscopy by the open technique provides a safe and effective diagnostic option in patients with metastatic ovarian cancer.
- Published
- 2005
20. Spontaneous uterine rupture at an unusual site due to placenta percreta in a 21-week twin pregnancy with previous cesarean section
- Author
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S, Topuz
- Subjects
Adult ,Uterine Rupture ,Cesarean Section ,Pregnancy ,Pregnancy Trimester, Second ,Hemoperitoneum ,Twins ,Humans ,Female ,Placenta Accreta ,Pregnancy, Multiple ,Hysterectomy - Abstract
Spontaneous uterine rupture is a rare, but serious complication of placenta percreta. This case report is about a spontaneous uterine rupture at an unusual site due to placenta percreta in a 21-week twin pregnancy with previous cesarean section. A 30-year-old, G3, P2 woman was referred to our unit in the 21st week of a twin pregnancy with acute abdomen. An emergency laparotomy was performed with the diagnosis of uterine rupture and intra-abdominal hemorrhage. A significant hemoperitoneum was found, with both fetuses freely floating in the peritoneal cavity. A large transverse rupture at the posterior isthmus wall was detected. Subtotal hysterectomy with preservation of both ovaries was performed. Pathological investigation of the uterus revealed placenta percreta.
- Published
- 2004
21. P24 Nursing students' knowledge and opinions towards Complementary and Alternative Medicine (CAM) in cancer patients
- Author
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S. Topuz, A. Akman, G. Uysal, and L. Büyükgönenc
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medicine.medical_specialty ,Nursing ,Oncology (nursing) ,business.industry ,Family medicine ,Alternative medicine ,Medicine ,Cancer ,General Medicine ,business ,medicine.disease - Published
- 2010
22. Impact of adjuvant treatments and risk factors on survival in 2023 FIGO stage IIB endometrial cancer patients: Turkish Gynecologic Oncology Group Study.
- Author
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Akgör U, Basaran D, Meydanli MM, Kuscu E, Demirkiran F, Topuz S, Sancı M, Akbayır O, Gultekin M, Salihoglu MY, Akilli H, Bese T, Fırat Z, Sozen H, Ozgul N, and Ayhan A
- Subjects
- Humans, Female, Retrospective Studies, Middle Aged, Aged, Turkey epidemiology, Radiotherapy, Adjuvant, Risk Factors, Adult, Chemotherapy, Adjuvant, Neoplasm Recurrence, Local pathology, Neoplasm Recurrence, Local therapy, Neoplasm Recurrence, Local mortality, Aged, 80 and over, Endometrial Neoplasms pathology, Endometrial Neoplasms therapy, Endometrial Neoplasms mortality, Neoplasm Staging
- Abstract
Objective: The aim of this study was to investigate the impact of adjuvant treatments, factors influencing recurrence, and survival data in patients with 2023 International Federation of Gynecology and Obstetrics (FIGO) stage IIB endometrial cancer., Methods: A retrospective analysis was conducted on patients with endometrial cancer who underwent surgery between 2005 and 2022 at seven different centers in Turkey. Demographic, clinicopathological, and survival data were collected and analyzed., Results: Among 7323 patients, 565 (7.7%) were classified as 2023 FIGO stage IIB based on pathological results. Of 565 patients, 214 were followed without receiving adjuvant treatment, while 335 (95.4%) received adjuvant radiotherapy, and 16 (4.6%) received radiotherapy and chemotherapy. The locoregional recurrence rate was higher in patients with a tumor size >4 cm (p=0.038) and myometrial invasion >50% (p=0.045). In patients with distant metastasis, the recurrence rate was lower in those with myometrial invasion <50% compared with myometrial invasion ≥50% (p=0.031). The impact of adjuvant treatment on endometrial cancer patients revealed no significant differences for both disease free survival (p=0.85) and overall survival (p=0.54). Subgroup analyses showed that in patients with deep myometrial invasion, adjuvant treatment was associated with a significant increase in overall survival (p=0.044), but there was no effect on disease-free survival (p=0.12)., Conclusions: Patients with stage IIB endometrial cancer with myometrial invasion ≥50% were more likely to have locoregional and distant metastases. Adjuvant radiotherapy or chemoradiotherapy did not demonstrate an overall survival benefit in these patients., Competing Interests: Competing interests: None declared., (© IGCS and ESGO 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2024
- Full Text
- View/download PDF
23. Effects of cycling training on balance and gait in children with Duchenne muscular dystrophy: A randomized controlled study.
- Author
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Bulut N, Yalçın Aİ, Topuz S, Gürbüz İ, Yılmaz Ö, and Karaduman A
- Subjects
- Humans, Child, Male, Female, Bicycling physiology, Treatment Outcome, Muscular Dystrophy, Duchenne rehabilitation, Muscular Dystrophy, Duchenne physiopathology, Postural Balance physiology, Exercise Therapy methods, Gait physiology
- Abstract
Background and Aims: Although aerobic exercises such as cycling and swimming are increasingly being recommended in Duchenne muscular dystrophy (DMD), their effect on gait and balance parameters is unclear. This study was aimed to investigate the effect of cycling training on balance and spatio-temporal gait parameters in children with DMD., Methods: Ambulant children (age range: 6.17-11.33 years) were randomly divided into two groups: home-based exercise training applied in the control group (n = 12) while 12 weeks of supervised submaximal lower extremity cycling training in addition to home-based exercise training performed in the study group (n = 11). Gait and balance parameters were evaluated using the GAITRite electronic walkway system and the Bertec Balance Check Screener™, respectively. Assessments were applied before and after 12 weeks of training., Results: The mean ages of the children in the study and control groups were 8.20 (SD:1.34) and 8.86 (SD:1.30) years, consecutively (p > 0.05). Considering the baseline values, the balance and spatio-temporal gait parameters of the children were similar except for the antero-posterior postural sway on the perturbed surface with eyes open (p > 0.05). There was a significant time x group interaction effect in favor of the study group for the antero-posterior postural sway of children on the normal surface with eyes open (F (1,58) = 12.62, p = 0.002). It was found that the antero-posterior postural sway on the normal surface with eyes open was improved in the study group within group comparison (F (1,10) = 8.50, p = 0.015)., Conclusions: The study showed that both the cycling and the home-based exercise training groups may maintain gait and balance parameters during the study. Adding a cycling training to the rehabilitation program can also provide additional contribution to improve antero-posterior balance., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
24. Investigation of Spatiotemporal Gait Characteristics, Balance, and Pain in Forefoot and Rearfoot Problems: Preliminary Results.
- Author
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Yıldız S, Kirdi E, Topuz S, and Bek N
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- Humans, Male, Female, Prospective Studies, Middle Aged, Adult, Pain Measurement, Foot Diseases physiopathology, Aged, Gait Analysis, Pain etiology, Pain physiopathology, Postural Balance physiology, Gait physiology, Forefoot, Human physiopathology
- Abstract
Background: Foot problems are common in the general adult population. Whereas older people experience foot problems because of multiple chronic diseases, younger people often have musculoskeletal foot problems related to overuse. Symptoms and severity may differ depending on the anatomical location of the problem, such as forefoot and rearfoot problems. We aimed to compare the differences in spatiotemporal gait characteristics, balance, and pain in musculoskeletal forefoot and rearfoot problems., Methods: Twenty-six patients with forefoot (14 participants) and rearfoot (12 participants) problems participated in this prospective study. Spatiotemporal gait characteristics (velocity, cadence, step time, step length, step-extremity ratio, stride length, base support, percentage of swing phase, percentage of stance phase, swing time, and stance time) were evaluated using an electronic walkway, and balance assessment was made using a balance check screener and trainer. The visual analog scale foot and ankle was used to determine patient pain levels. The Mann-Whitney U test was used to determine differences between groups., Results: There were no significant differences between groups regarding spatiotemporal gait characteristics (P > .05). The eyes closed normal stability and eyes open perturbed stability scores were lower in patients with rearfoot problems (P < .05). Pain intensity evaluated with the visual analog scale foot and ankle was higher in patients with rearfoot problems (P < .05)., Conclusions: Pain levels and balance deficits in this study were higher in patients with rearfoot problems. The balance evaluation and possible effects of pain management on balance should be considered, especially in patients with rearfoot problems, in aspects of treatment.
- Published
- 2024
- Full Text
- View/download PDF
25. A dataset of 40'000 trees with section-wise measured stem diameter and branch volume from across Switzerland.
- Author
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Didion M, Herold A, Thürig E, Topuz S, Vulovic Z, Abegg M, Nitzsche J, Stillhard J, and Glatthorn J
- Subjects
- Switzerland, Plant Stems anatomy & histology, Forests, Trees
- Abstract
Estimating growing stock is one of the main objectives of forest inventories. It refers to the stem volume of individual trees which is typically derived by models as it cannot be easily measured directly. These models are thus based on measurable tree dimensions and their parameterization depends on the available empirical data. Historically, such data were collected by measurements of tree stem sizes, which is very time- and cost-intensive. Here, we present an exceptionally large dataset with section-wise stem measurements on 40'349 felled individual trees collected on plots of the Experimental Forest Management project. It is a revised and expanded version of previously unpublished data and contains the empirically derived coarse (diameter ≥7 cm) and fine branch volume of 27'297 and 18'980, respectively, individual trees. The data were collected between 1888 and 1974 across Switzerland covering a large topographic gradient and a diverse species range and can thus support estimations and verification of volume functions also outside Switzerland including the derivation of whole tree volume in a consistent manner., (© 2024. The Author(s).)
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- 2024
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26. The evaluation of miR-1181 and miR-4314 as serum microRNA biomarkers for epithelial ovarian cancer diagnosis and prognosis.
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Minareci Y, Ak N, Sozen H, Tosun OA, Kucukgergin C, Aydin F, Bingul İ, Salihoglu MY, and Topuz S
- Subjects
- Humans, Female, Carcinoma, Ovarian Epithelial diagnosis, Carcinoma, Ovarian Epithelial genetics, Biomarkers, Tumor genetics, Real-Time Polymerase Chain Reaction, Gene Expression Regulation, Neoplastic genetics, MicroRNAs metabolism, Ovarian Neoplasms diagnosis, Ovarian Neoplasms genetics, Ovarian Neoplasms pathology, Neoplasms, Glandular and Epithelial diagnosis, Neoplasms, Glandular and Epithelial genetics
- Abstract
Aim: Epithelial ovarian cancer (EOC) is the most ominous tumor of gynecological cancers due to its poor early detection rate and unfavorable prognosis. To date, there is no reliable screening method for the diagnosis of ovarian cancer at an early stage. MiRNAs are small non-coding RNA molecules, and their main function is to regulate gene expression. The present study compared the serum miR-1181 and miR-4314 levels in patients with EOC and healthy controls to measure the diagnostic and prognostic value as candidate biomarkers., Materials and Methods: We collected serum samples from a total of 135 participants (69 patients with EOC and 66 healthy controls). Relative expressions of miR-1181 and miR-4314 were measured by quantitative real-time polymerase chain reaction assay (qPCR)., Results: The present study revealed that both serum miR-1181 and miR-4314 levels in patients with EOC were significantly increased compared to healthy controls for each marker. In addition, there was a significant relationship between miR-1181 and miR-4314 overexpressions and the stage and prognosis of the disease. Finally, patients with high expression levels of miR-1181 and miR-4314 had significantly shorter survival rates than those with low expression levels., Conclusion: The current study proposed that serum miR-1181 and miR-4314 could discriminate the EOC patients from healthy controls. In addition, both miR-1181 and miR-4314 may be predictive biomarkers for ovarian cancer prognosis. Further studies are needed to confirm the findings of the present study., (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
- Published
- 2024
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27. Sentinel lymph node biopsy with carbon dye in endometrial cancer: a single center, prospective cohort study.
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Minareci Y, Sozen H, Altinkara Hacioglu B, Yuvanc HO, Topuz S, and Salihoglu MY
- Subjects
- Female, Humans, Sentinel Lymph Node Biopsy methods, Prospective Studies, Cohort Studies, Carbon, Lymph Nodes pathology, Lymph Node Excision, Indocyanine Green, Sentinel Lymph Node diagnostic imaging, Sentinel Lymph Node surgery, Sentinel Lymph Node pathology, Endometrial Neoplasms surgery
- Abstract
Background: Many agents have been used for the detection of sentinel lymph nodes in endometrial cancer. Carbon dye, which has a strong staining ability and high contrast due to its dark black color, identifies the lymph nodes efficiently. Our aim was to evaluate the safety and efficacy of carbon dye for the detection of sentinel lymph nodes in endometrial cancer., Methods: We conducted a single-center, prospective, cohort study in 89 patients with early-stage endometrial cancer between September 2021 and August 2022. The procedure was performed under laparoscopy., Results: The sensitivity and negative predictive value of the sentinel lymph node biopsy (SLNB) with carbon dye injection were 83.3% and 98.8%, respectively. Mapping identified at least one sentinel lymph node in 84 patients (94.4%) on one pelvic side and at least one sentinel lymph node in 73 patients (82.0%) on each pelvic side out of 89 patients. In addition, no carbon dye-associated allergic reaction was detected., Conclusion: Carbon dye is a non-allergenic, inexpensive, and effective agent for SLNB with a satisfying sensitivity and a negative predictive value. In addition, both unilateral and bilateral detection rates were sufficient. Accordingly, carbon dye may be a promising tracer and a considerable option, particularly for low-income countries., (© 2024. The Author(s).)
- Published
- 2024
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28. Hormonal Therapy in Pretreated Patients With Recurrent Ovary Granulosa Cell Tumor.
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Dogan I, Aydin E, Topuz S, Saip P, Salihoglu MY, and Aydiner A
- Subjects
- Adult, Female, Humans, Middle Aged, Anastrozole therapeutic use, Leuprolide therapeutic use, Retrospective Studies, Tamoxifen therapeutic use, Granulosa Cell Tumor drug therapy, Granulosa Cell Tumor surgery, Ovarian Neoplasms drug therapy, Ovarian Neoplasms surgery
- Abstract
Objective: To evaluate the effectiveness of hormonal therapy (HT) in patients with recurrent adult ovary granulosa cell tumors. Methods: The clinical and treatments features of the patients who received HT were studied retrospectively. The efficacy and safety of HT were evaluated. The Kaplan-Meier technique was used to conduct survival analysis. Results: The research involved a total of thirteen patients. The median age of the participants was 49 years (range: 34-61). Since diagnosis, the median number of surgeries has been three (range: 2-8). At least one chemotherapy regimen has been administered to 12 (92.3%) patients. Ten of the patients (76.9%) had at least two metastatic areas. Lung metastases were found in two (15.4%) of the patients. Inhibin B levels were elevated in 81.2% of patients before hormone treatment. The patients received different HTs (Leuprolide acetate + anastrozole-three patients, leuprolide acetate + tamoxifen-six patients, only anastrozole-three patients, only tamoxifen-one patients). The median progression-free survival was found 17.7 months (95 % CI: 14.7-20.6). In four (33.4%) patients, an overall response (complete or partial) was identified. A stable response was observed in eight (66.7%) patients. Conclusions: HT is effective in pretreated individuals with recurrent ovarian granulosa cell tumors, according to this research. Despite the limited number of patients and treatment variability, disease control was achieved in all patients. Also, we found that Inhibin B levels were associated with treatment response., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Published
- 2024
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29. Effectiveness of adjuvant systemic therapy following complete cytoreductive surgery in patients with recurrent granulosa cell tumours of the ovary.
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Yumru Celiksoy H, Dickie C, Seckl MJ, Aydın E, Sozen H, Topuz S, and Fotopoulou C
- Subjects
- Adult, Female, Humans, Cytoreduction Surgical Procedures, Neoplasm Recurrence, Local drug therapy, Neoplasm Recurrence, Local surgery, Adjuvants, Immunologic, Adjuvants, Pharmaceutic, Granulosa Cell Tumor drug therapy, Granulosa Cell Tumor surgery, Ovarian Neoplasms drug therapy, Ovarian Neoplasms surgery
- Abstract
Aim of the present analysis is to compare the impact of antihormonal therapy versus cytotoxic chemotherapy versus a watch a wait approach on disease-free survival (DFS) in the adjuvant setting of patients who underwent complete cytoreductive surgery(CRS) for recurrent adult type granulosa cell tumours of the ovary (GCT). Moreover, we wished to identify prognostic risk factors for recurrence. We included recurrent GCT-patients who underwent CRS resulting in total macroscopic tumour clearance, treated in two gynaecological cancer centres over a 20-year period (2000-2020). CRS was performed for 51 recurrences in 26 GCT-patients. Adjuvant systemic treatments were as follows: chemotherapy in 21 cases, hormonotherapy in 10 cases, no systemic treatment in 20 cases. There were no statistically significant differences in DFS between chemotherapy, hormonotherapy and no systemic treatment: median DFS was 57, 36 and 57 months, respectively (p = 0.616). Extra-pelvic and/or multifocal tumour dissemination were found to be independent predictive factors for subsequent recurrences. In the cases with both lower and upper abdominal involvement (n = 18), patients who received chemotherapy (n = 9) had longer DFS than those who had hormonotherapy (n = 2) or no adjuvant therapy (n = 7) at all: median DFS was 36, 13 and 15 months, respectively (p = 0.9). Our findings do not encourage the administration of adjuvant therapy following complete CRS for GCT-relapse. Selected high-risk patients with disseminated disease may derive clinical benefit from additional chemotherapy, larger-scale multicentre studies are warranted to define treatment algorithms for this rare disease., (© 2024. The Author(s).)
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- 2024
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30. Clarifying the relationships between trunk muscle endurance, respiratory muscle strength and static/dynamic postural control in Latin dancers.
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Özkal Ö, Demircioğlu A, and Topuz S
- Abstract
Sufficient study has not been performed to clarify the role of trunk/respiratory muscles strength/endurance in providing postural control in dancers. The purpose of this study was to identify predictors affecting static/dynamic postural control in Latin dancers and to compare these measurements with non-dancers. The study included 38 (26F; 12 M) Latin dancers and 33 (21F; 11 M) non-dancers. Static/dynamic postural control, trunk muscle endurance, respiratory muscle strength/pulmonary functions, flexibility, and reaction tests were assessed with a force platform system, the McGill battery, spirometer, sit-and-reach test and Nelson-reaction-tests, respectively. Trunk muscle endurance times, respiratory muscle strength, FEV
1 /FVC, gender, hours of training per week and dancing experience were significant predictors of static/dynamic postural control in dancers ( p < 0.05). All the trunk muscle endurance times, reaction tests results, and maximal inspiratory pressure were higher in the dancers compared to the non-dancers ( p < 0.05). The limits of stability for forward and backward directions were higher, and anteroposterior sway in normal stability with eyes open was lower in the dancers compared to the non-dancers ( p < 0.05). Trunk muscles endurance, respiratory muscle strength, dancing experience, and hours of training per week were positively associated with static/dynamic postural control. These predictors should be taken into consideration to improve postural control in dancers.- Published
- 2024
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31. Comparison of transumbilical and periumbilical median incisions in ovarian cancer surgery
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Yumru Çeliksoy H, Cantürk MM, Sözen H, Çelik E, Baktıroğlu HM, Salihoğlu Y, and Topuz S
- Abstract
Objective: The umbilicus is traditionally circumvented while performing a vertical midline abdominal incision. There is a gap in knowledge pertaining to avoiding the umbilicus. Our aim was to investigate whether a transumbilical (TU) or periumbilical (PU) midline incision conferred any advantage to the patient., Material and Methods: This was a retrospective cohort study of patients undergoing ovarian cancer surgery with a midline incision, from the pubic tubercle to the xiphoid. All surgery was performed by the same team of gyneacological oncologists. Patients were classified into two groups according to the midline incision used, TU or PU. The primary endpoint was the incision wound complication rate., Results: TU and PU midline incisions were performed in 54 and 68 patients, respectively. There were no differences between the two groups in terms of patient characteristics and operative details. The two groups had comparable rates of complications, including wound infection (7.4% vs. 10.3%, p=0.75), deep surgical site infection (11.1% vs. 4.4%, p=0.18), evisceration (3.7% vs. 4.4%, p=0.99) and incisional hernia (33.3% vs. 33.8%, p=0.99)., Conclusion: Our findings suggest that circumventing the umbilicus during laparotomy did not have any advantage. Future prospective randomized trials are warranted to validate this finding., Competing Interests: Conflict of Interest: No conflict of interest is declared by the authors., (©Copyright 2023 by the Turkish-German Gynecological Education and Research Foundation. Journal of the Turkish-German Gynecological Association is published by Galenos Publishing House.)
- Published
- 2023
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32. Comparison of gait and sagittal plane arm swing between individuals with adolescent idiopathic scoliosis and healthy individuals.
- Author
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Tekin S, Yagci G, Topuz S, and Demirkiran G
- Subjects
- Adolescent, Humans, Arm, Gait, Scoliosis
- Abstract
Arm swing and energy consumption play an important role in the realization of an effective gait. However, research on arm swing and energy consumption during gait in individuals with adolescent idiopathic scoliosis (AIS) is limited. The aim of this study was to investigate the spatiotemporal characteristics of gait, arm swing angles in the sagittal plane, energy consumption in individuals with AIS, to compare them with their healthy peers in this regard. 26 diagnosed with AIS and 21 healthy were included in this study. Evaluation measures were based on the Cobb angle, axial trunk rotation, trunk symmetry, sagittal curve measurements, spatiotemporal characteristics of gait with the GAITRite electronic walkway, sagittal plane arm swing with two video-camera recordings, and energy consumption. There were a decrease in right- sided sagittal arm swing, an increase in energy consumption, in left-side step time and right-side double support time in the scoliosis group compared to the control group. The other spatiotemporal characteristics of the gait were similar in both groups. The evaluation of arm swing, energy consumption, and gait of individuals with AIS may contribute to the development of rehabilitation programs by better identifying the deficiencies of individuals with AIS.
- Published
- 2023
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33. Gait initiation in multiple sclerosis patients with and without functional loss.
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Salamci M, Salcı Y, Topuz S, Yalçın Aİ, Acar Özen P, and Tuncer A
- Subjects
- Humans, Cross-Sectional Studies, Prospective Studies, Postural Balance physiology, Gait physiology, Multiple Sclerosis complications
- Abstract
Background: Gait initiation (GI) is an important functional task related to balance and gait performance. In addition, it has predictive importance for falls and postural instability in patient with multiple sclerosis (MS). However, it is uncertain how GI is affected in patients in the early stage of MS (Expanded Disability Status Scale (EDSS) ≤3). In this study, it was aimed to investigate the anticipatory postural adjustments (APAs), posterior center of pressure (COPap) displacement, and spatiotemporal variability during GI in patients with and without functional loss in the early stage of MS., Methods: Forty-four participants (31 MS patients and 13 healthy subjects) involved in this prospective cross-sectional study were divided into three groups: Group-I: Patients without functional loss (EDSS 0 to 1.5) (n = 14), Group-II: Patients with functional loss (EDSS 2 to 3) (n = 17) and Group-III: Healthy subjects (n = 13). Electromyographic activity of the bilateral tibialis anterior (TA) and gastrocnemius medialis (GM) and COPap displacement were recorded during the postural phase of GI. Additionally, spatiotemporal parameters were recorded within the first three steps, and the coefficient of variation was calculated with 40 walks for variability., Results: There were significant differences in the Kruskal-Wallis tests of variables (p<0.05). Group-I demonstrated smaller APAs magnitudes in TA [stance (p = 0.01), swing (p = 0.01)], GM of swing limb (p<0.0001), and smaller COPap displacement (p<0.0001) compared to group-III. Group-II demonstrated smaller APAs magnitudes in all muscles (p<0.0001) compared to group-III and the smallest COPap displacement (p<0.0001). Group-I showed a significant increase in stride width variability compared to group-III (p = 0.01). Group-II showed a significant increase in several variabilities [first stride length (p<0.0001), second stride time (p<0.0001), first double support time (p<0.0001), stride width (p<0.0001)] compared to group-III., Conclusion: Patients in the early stage of MS had impairment in both the postural and locomotor phases of GI with more obvious in the patients with functional loss. The results indicate that MS patients without functional loss have difficulty initiating gait. Although there is no functional loss, the patients have a risk of falls, postural instability, and gait impairment due to their inability to initiate gait effectively. As a result, rehabilitation is necessary even if there is no functional loss in patients with MS., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)
- Published
- 2023
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34. Incisional hernia after ovarian debulking surgery.
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Yumru Celiksoy H, Sozen H, Canturk MM, Baktiroglu HM, Salihoglu Y, and Topuz S
- Abstract
Objectives: The purpose of our study was to explore the incidence and contributing variables of an incisional hernia after debulking surgery for advanced ovarian cancer., Material and Methods: The imaging of patients who underwent debulking surgery with an extended vertical incision was re-evaluated for incisional hernias at one-year follow-up, and their medical records were reviewed. We performed univariate and multivariate analysis to find out the risk factors for an incisional hernia., Results: The overall annual incidence of incisional hernia was 26.7 percent (46 of 172). Univariate analysis revealed a statistically significant relationship between age, body mass index (BMI), and the length of the incision and the incidence of an incisional hernia. The only factor identified by multivariate analysis as being independently related with the development of an incisional hernia within a year of the operation was BMI (OR 1.12, 95% CI 1.01-1.25, p = 0.04)., Conclusions: Incisional hernia rates were high after ovarian cancer surgeries, and BMI was the independent factor significantly linked to hernia formation. To reduce the high ratio of incisional hernia among these group of patients, preventative strategies should be researched and applied.
- Published
- 2023
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35. The role of ultrasonographically measured rectus femoris muscle on falls in community-dwelling older adults: a single-center study.
- Author
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Güner M, Boğa İ, Topuz S, Okyar Baş A, Ceylan S, Çöteli S, Kahyaoğlu Z, Balcı C, Doğu BB, Cankurtaran M, and Halil M
- Abstract
Background: There are many risk factors for falls and sarcopenia has emerged as an important risk factor. Measuring muscle mass is a useful method to determine sarcopenia. Our aim was to determine the difference in muscle mass between older adults with (fallers) and without history of falls (non-fallers) using ultrasonography (US)., Methods: Two hundred ten geriatric patients were enrolled. Fall was defined as an event declared by the person who fell. Sarcopenia was defined by EWGSOP2 criteria. Muscle mass was assessed by muscle ultrasonography of five different muscles., Results: The mean age of the whole study group was 74.1 ± 6.3 years and 58.1% (n = 122) of the total study population was female. Among the participants, 69 patients (31.3%) had a fall history. The sarcopenia ratio was 23.2% in the fallers, and it was 13.7% in the non-fallers, the difference was statistically insignificant (p > 0.05), the measurement of rectus femoris muscle (RF) thickness and cross-sectional area (RFCSA) were significantly smaller among the fallers than non-fallers (p < 0.05). The ROC analysis revealed that RF and RFCSA could determine the history of falls [for RF area under curve (AUC): 0.606, 95% confidence interval (CI) 0.526-0.686, p = 0.010 and for RFCSA AUC: 0.621, 95% CI 0.538-0.704, p = 0.004]. RFCSA was statistically relevant with a history of falls, regardless of age, sex, multimorbidity, incontinence, nutritional status, and frailty status., Conclusion: Decreased RF and RFCSA determined by muscle US is a potentially modifiable risk factor for falls in older adults. Muscle US may be used for determining the risk of falls in older adults., (© 2023. The Author(s), under exclusive licence to European Geriatric Medicine Society.)
- Published
- 2023
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36. Development of a new instrument to evaluate gait characteristics of individuals with Duchenne Muscular Dystrophy: Gait Assessment Scale for Duchenne Muscular Dystrophy, and its validity and reliability.
- Author
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Aydın Yağcıoğlu G, Alemdaroğlu Gürbüz İ, Topuz S, and Yılmaz Ö
- Abstract
Background: Patients with Duchenne Muscular Dystrophy (DMD) have gait disorders. Therefore, specific gait assessment tools are needed., Aims: The aim of this study was to develop a gait assessment instrument for DMD patients (DMD-GAS), and investigate its validity and reliability., Study Design: The scale was developed considering the expert opinions which included 10 physiotherapists who had experience in the management of patients with DMD, and the Content Validity Index (CVI) was calculated. The final version of the DMD-GAS that was agreed upon the experts consisted of 10 items, and each item scored between 0 and 2. The intra-rater reliability was established by the video analysis of children with a 1-month interval and inter-rater reliability was determined by the scores of 3 physiotherapists., Subjects: The study included 56 patients with DMD., Outcome Measures: The criterion validity was determined by investigating the relationship between the total score of the DMD-GAS and Motor Function Measure (MFM), 6 Minute Walk Test (6MWT), and the data obtained from GAITRite., Results: The CVI of the DMD-GAS was 0.90 (p < 0.05). The construct validity and internal consistency of the DMD-GAS were excellent as well as the intra- and inter-rater reliability (>0.90). Moderate-to-very strong correlations were found between the total score of the DMD-GAS and the MFM-total score (r = 0.78), 6MWT (r = 0.71), gait speed (r = 0.50), stride length (r = 0.56), and base of support (r = -0.70) (p < 0.01)., Conclusions: The results indicated that DMD-GAS was a reliable and valid instrument to determine gait characteristics of the patients with DMD in clinical settings., Clinical Trial Number: NCT05244395., Competing Interests: Declaration of competing interest The authors report there are no competing interests to declare., (Copyright © 2023 Elsevier B.V. All rights reserved.)
- Published
- 2023
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37. The effect of mirror therapy on joint movement, pain and functionality in acute upper limb burns.
- Author
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Seyyah M and Topuz S
- Subjects
- Humans, Male, Female, Adolescent, Young Adult, Adult, Middle Aged, Aged, Mirror Movement Therapy, Pain etiology, Exercise Therapy, Upper Extremity injuries, Range of Motion, Articular, Treatment Outcome, Burns complications, Burns therapy, Arm Injuries therapy
- Abstract
Objective: Mirror therapy is aimed at developing a normal proprioceptive perception for the area with pain or movement restriction by making use of the person's monitoring of the healthy side movements thanks to the mirror's reflective feature. The aim of this study is to investigate the effect of mirror therapy on joint range of motion, pain and functionality in acute upper extremity burn injuries., Methods: Demographic and burn-specific data of individuals with upper extremity burns were recorded. Individuals were divided into two groups. Standard treatment was applied to the first group, and mirror treatment in addition to the standard treatment was applied to the second group for 30 sessions, 5 days a week for 6 weeks. In the standard treatment program, passive, active-assisted and active ROM, strengthening, stretching, resistant and functional exercises were applied. In the mirror therapy group, active exercises were performed on the healthy side by covering the burn area in the mirror box. Before and after the treatment, joint range of motion(ROM) was evaluated with Universal Goniometer, pain intensity was evaluated with Visual Analog Scale and upper extremity functions were evaluated with QuickDASH., Results: A total of 32 (23 Male, 9 Female) individuals between the ages of 18-65 were included. The mean total burn surface area was 12.93 ± 9.80 in the standard treatment and 6.12 ± 2.96 in the mirror treatment. The groups were similar in terms of ROM change (p > 0.05). The pretest/posttest pain scores of both the standard therapy and mirror therapy groups were similar (p > 0.05). There was no statistically significant difference in terms of pretest and posttest QuickDASH scores according to the groups (p > 0.05). The difference between the pretest/posttest QuickDASH scores of both Standard treatment and Mirror treatment groups was statistically significant., Conclusion: This study showed that the standard physiotherapy and rehabilitation program applied in the acute period in upper extremity burns and the mirror treatment applied in addition to this program provide similar improvements in joint range of motion and pain., (Copyright © 2023 Elsevier Ltd and International Society of Burns Injuries. All rights reserved.)
- Published
- 2023
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38. Smartphone use affects gait performance, spinal kinematics and causes spinal musculoskeletal discomfort in young adults.
- Author
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Metin G, Topuz S, and Yagci G
- Subjects
- Humans, Young Adult, Biomechanical Phenomena, Cross-Sectional Studies, Walking, Smartphone, Gait
- Abstract
Background: Smartphone use may lead to alterations in spinal kinematics and musculoskeletal discomfort., Objectives: The aim of this study was to evaluate the effect of smartphone use on spinal kinematics, and to examine the relationship between smartphone addiction, spinal discomfort, and gait parameters., Design: Cross-Sectional Study., Methods: The study included 42 healthy adults aged 18-30 years. A photographic method was used for spinal kinematic evaluation in sitting, standing and at the end of a 3-min walk. GAITRite electronic walkway was used for spatiotemporal gait parameters. Smartphone addiction was evaluated with the Smartphone Addiction Scale - Short Version (SAS-SV). The Cornell Musculoskeletal System Discomfort Questionnaire (CMDQ) was used to evaluate feelings of discomfort and pain., Results: There was an increase in head, cervical, and thoracic flexion angles while sitting, standing, and at the end of a 3-min walk. Similarly, an increase in thoracolumbar and lumbar flexion angles was observed only in the sitting position (p < 0.05). While using a smartphone during walking, cadence, walking speed, step length decreased, while step duration and double support duration increased (p < 0.05). A statistically significant correlation was determined between the SAS-SV and CMDQ scores (p < 0.05)., Conclusion: The study showed that smartphone use has an impact on spinal kinematics during sitting, standing and at the end of a 3 min-walk, as well as on the spatiotemporal parameters of gait. This study suggest that smartphone addiction should be taken into consideration due to its potential to cause musculoskeletal discomfort and there may be a need to raise public awareness on this matter., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper, (Copyright © 2023 Elsevier Ltd. All rights reserved.)
- Published
- 2023
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39. Examination of the relationship between foot-body posture and balance and gait in Duchenne muscular dystrophy.
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Aydın Yağcıoğlu G, Yılmaz Ö, Alemdaroğlu Gürbüz İ, Bulut N, Karaduman A, Özkal Ö, and Topuz S
- Subjects
- Child, Humans, Biomechanical Phenomena, Gait, Lower Extremity, Posture, Muscular Dystrophy, Duchenne complications, Muscular Dystrophy, Duchenne diagnosis
- Abstract
Background: Although the gait and balance disturbances of Duchenne muscular dystrophy (DMD) patients were evaluated by using different methods in literature, the impact of the foot and body posture on gait and balance has not been clearly described yet in DMD., Aim: The aim of this study was to examine the relationship between foot-body posture and gait and balance in patients with DMD., Methods: Ambulatory patients with DMD who had > 90° range of motion at ankle joint were included in the study. Foot and body posture were evaluated with the Foot Posture Index (FPI-6) and the New York Posture Rating (NYPR). The limitation degree at the ankle joint (ALD) was recorded. Gait characteristics and balance were evaluated objectively by using the GAITRite system and the Bertec Balance Check Screener
™ force platform system, respectively., Results: A total of 38 ambulatory patients with DMD (age: 92.44 ± 17.91 months) were recruited. Both the right and left foot FPI-6 scores were correlated with GAITRite parameters such as ambulation time, gait speed, number of steps, and left and right stride lengths (p < 0.05). A relationship was determined between right foot FPI-6 score and anterior-posterior limits of stability (LoS) obtained by force platform (p < 0.05). NYPR score was also correlated with the postural control parameters such as left and right base of support and anterior posterior LoS (p < 0.05)., Conclusion: The current findings indicate a contribution of foot and body posture to gait and balance disorders of children with DMD., Clinical Trial Number: NCT04353167, Date of registration: April 16, 2020., (© 2022. The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland.)- Published
- 2023
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40. Validity, reliability, and Rasch analysis of the orthotics and prosthetics users' survey: Turkish version of the lower-extremity functional status.
- Author
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Soyer K, Demirdel S, Erol Çelik S, Topuz S, and Karahan S
- Subjects
- Humans, Reproducibility of Results, Functional Status, Surveys and Questionnaires, Orthotic Devices, Lower Extremity, Psychometrics methods, Artificial Limbs
- Abstract
Background: It is well known that questionnaires and scales are easy to use, cheap, and provide fast results. In the clinical setting, it will be easier and more comfortable to evaluate lower-extremity functions in both prosthesis and orthosis users with a single questionnaire., Objectives: To study the Turkish version of the orthotics and prosthetics users' survey lower-extremity functional status (OPUS-LEFS) and investigate its reliability and validity in the Turkish prosthesis and orthosis users., Study Design: After forward and backward translation process, test-retest, internal consistency, validity, dimensionality, and Rasch analysis were done for 139 participants., Methods: Participants with a lower-limb prosthesis or orthosis were recruited in this study. Test and retest of the survey was done 1-3 days apart. For convergent validity, Nottingham Health Profile was used. Pearson correlation coefficient was used to analyze test-retest reliability; Cronbach's alpha for internal consistency, Spearman's correlation coefficient for validity, exploratory factor analysis by means of Kaiser-Meyer-Olkin and Bartlett's value of sphericity for dimensionality, and Rasch analysis were used., Results: Test-retest reliability of OPUS-LEFS showed very strong correlation (0.994) and for internal consistency with Cronbach's alpha value 0.71 of the Turkish version of OPUS-LEFS. Analyses showed that OPUS-LEFS is valid ( p < 0.001) and significant ( p < 0.001)., Conclusions: The Turkish version of the OPUS-LEFS has been shown to be a valid and reliable tool in evaluating both orthosis and prosthesis users with a self-administered questionnaire for LEFS., (Copyright © 2023 International Society for Prosthetics and Orthotics.)
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- 2023
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41. Early spontaneous movements and spatiotemporal gait characteristics in preterm children.
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Topal Y, Yardımcı-Lokmanoğlu BN, Topuz S, and Mutlu A
- Subjects
- Infant, Newborn, Humans, Child, Adult, Child, Preschool, Prospective Studies, Gestational Age, Peer Group, Gait, Walking
- Abstract
This study aimed to analyze spatiotemporal gait characteristics of preterm children from 3 to 4 years of age according to different gestational age groups and to examine the relationship between the detailed general movements assessment and spatiotemporal gait characteristics. A total of 74 preterm children, 32 extremely preterm and very preterm (EP-VP, < 32 weeks gestational age) and 42 moderate to late preterm (MLP, 32 to < 37 weeks gestational age), were included in this prospective study, along with 38 term children. Early spontaneous movements of preterm children were assessed from videos at 9-20 weeks post-term according to the general movements assessment, which determines the Motor Optimality Score-Revised (MOS-R). The spatiotemporal gait characteristics of all children were evaluated using the GAITRite
® electronic walkway at self-selected walking speeds. EP-VP children walked with shorter step lengths (p = 0.039), and MLP children walked with greater step length variability (p = 0.003) than their term peers. The MOS-R results were related to step length (r = 0.36, p = 0.042), step length variability (r = -0.56, p = 0.001), and base of support (r = -0.37, p = 0.038) in EP-VP children. The MOS-R subcategories, age-adequate movement repertoire, and postural patterns were related to some of the spatiotemporal gait characteristics, including step length, step length variability, and base of support (p < 0.05). Conclusion: EP-VP and MLP children might catch up to their term peers at 3 to 4 years of age in terms of most gait parameters. In addition to the MOS-R, age-adequate movement repertoire and postural patterns of preterm children without cerebral palsy in early life may be a marker of later neurodevelopmental dysfunction. What is Known: • Preterm children walk with a wider step width, a greater step length asymmetry and step time, and a shorter stride length at 18 to 22 months of age compared with term children at a self-selected speed, while these differences disappear in children 4.5-5 years old and older. What is New: • Early spontaneous movements were related to some spatiotemporal gait characteristics. • Preterm children might catch up to term children at 3-4 years of age in spatiotemporal gait characteristics while walking at a self-selected speed., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)- Published
- 2023
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42. Relationships of Fall Risk With Frailty, Sarcopenia, and Balance Disturbances in Mild-to-Moderate Alzheimer's Disease.
- Author
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Güner Oytun M, Topuz S, Baş AO, Çöteli S, Kahyaoğlu Z, Boğa İ, Ceylan S, Doğu BB, Cankurtaran M, and Halil M
- Abstract
Background and Purpose: Cognitive impairment is one of the main risk factors for falls, and hence it commonly coexists with balance issues. Frailty and sarcopenia are intertwined and prevalent in dementia, and are closely related to falls. We aimed to determine the relationships of the fall risk with balance disturbances, sarcopenia, and frailty in mild-to-moderate Alzheimer's disease (AD)., Methods: The study enrolled 56 patients with probable AD. A comprehensive geriatric assessment was performed, and muscle strength and mass, performance status, gait, and balance were evaluated. All parameters were compared between fallers and nonfallers with AD., Results: Fallers comprised 53.6% of the study population. The demographic features and AD stages did not differ between fallers and nonfallers. Fallers were more frail than nonfallers ( p <0.05). Frailty was found to be independently associated with fall history (odds ratio=2.15, 95% confidence interval=1.20-3.82, p =0.031). We found that falls were not associated with AD stage, muscle mass and function, balance and geriatric syndromes except urinary incontinence in patients with AD ( p >0.05)., Conclusions: We found that falls were not influenced by AD stage. Both physical and cumulative frailty were strongly associated with falls in patients with mild-to-moderate AD., Competing Interests: The authors have no potential conflicts of interest to disclose., (Copyright © 2023 Korean Neurological Association.)
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- 2023
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43. A Modified Version of the Forgotten Joint Score-12 in Lower Limb Amputees: Validity and Reliability Study.
- Author
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Karakaş G, Özçadırcı A, and Topuz S
- Subjects
- Humans, Quality of Life, Reproducibility of Results, Amputation, Surgical, Lower Extremity, Surveys and Questionnaires, Amputees rehabilitation
- Abstract
Adaptation to prosthesis is important for occupation, quality of life, and participation in social life, so it needs to be evaluated. The aim of this study was to determine the validity and reliability of the Forgotten Joint Score-12 (FJS-12) in lower limb amputees. The FJS-12 was applied to 80 amputees. Criterion-referenced validity was assessed using the activity restriction subparameter of Trinity Amputation and Prosthesis Experience Scale (TAPES). The internal consistency of the FJS-12 was high (Cronbach's α = .943). A statistically significant very good negative correlation was determined between the FJS-12 and the activity restriction subparameter of TAPES ( r = -.641; p < .001). The results of this study showed that FJS-12 is a valid and reliable measurement tool that can be used to assess the adaptation to prosthesis in amputees. Evaluation of prosthesis awareness in daily living activities of amputees is important in terms of establishing occupational therapy and rehabilitation programs.
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- 2023
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44. Metabolic pathways of potential miRNA biomarkers derived from liquid biopsy in epithelial ovarian cancer.
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Gumusoglu-Acar E, Gunel T, Hosseini MK, Dogan B, Tekarslan EE, Gurdamar B, Cevik N, Sezerman U, Topuz S, and Aydinli K
- Abstract
Epithelial ovarian cancer (EOC) is the type of OC with the highest mortality rate. Due to the asymptomatic nature of the disease and few available diagnostic tests, it is mostly diagnosed at the advanced stage. Therefore, the present study aimed to discover predictive and/or early diagnostic novel circulating microRNAs (miRNAs or miRs) for EOC. Firstly, microarray analysis of miRNA expression levels was performed on 32 samples of female individuals: Eight plasma samples from patients with pathologically confirmed EOC (mean age, 45 (30-54) years), eight plasma samples from matched healthy individuals (HIs) (mean age, 44 (30-65) years), eight EOC tissue samples (mean age, 45 (30-54) years) and eight benign ovarian (mean age, 35 (17-70) years) neoplastic tissue samples A total of 31 significantly dysregulated miRNAs in serum and three miRNAs in tissue were identified by microarray. The results were validated using reverse transcription-quantitative PCR on samples from 10 patients with pathologically confirmed EOC (mean age, 47(30-54) years), 10 matched His (mean age, 40(26-65) years], 10 EOC tissue samples (mean age, 47(30-54) years) and 10 benign ovarian neoplastic tissue samples (mean age, 40(17-70) years). The 'Kyoto Encyclopedia of Genes and Genomes' (KEGG) database was used for target gene and pathway analysis. A total of three miRNAs from EOC serum (hsa-miR-1909-5p, hsa-miR-885-5p and hsa-let-7d-3p) and one microRNA from tissue samples (hsa-miR-200c-3p) were validated as significant to distinguish patients with EOC from HIs. KEGG pathway enrichment analysis showed seven significant pathways, which included 'prion diseases', 'proteoglycans in cancer', 'oxytocin signaling pathway', 'hippo signaling pathway', 'adrenergic signaling in cardiomyocytes', 'oocyte meiosis' and 'thyroid hormone signaling pathway', in which the validated miRNAs served a role. This supports the hypothesis that four validated miRNAs, have the potential to be a biomarker of EOC diagnosis and target for treatment., Competing Interests: The authors declare that they have no competing interests., (Copyright: © Gumusoglu-Acar et al.)
- Published
- 2023
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45. Central nervous system metastasis in gynecologic cancers: Seeking the prognostic factors.
- Author
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Minareci Y, Ak N, Tosun OA, Sozen H, Saip PM, Topuz S, and Salihoglu MY
- Subjects
- Humans, Female, Prognosis, Retrospective Studies, Central Nervous System pathology, Central Nervous System Neoplasms therapy, Genital Neoplasms, Female, Ovarian Neoplasms pathology
- Abstract
Objective: Central nervous system (CNS) metastasis originating from gynecological cancer is a very rare and late manifestation of the disease. Therefore, there is still limited data on prognostic factors for survival. The objective of the present study is to identify prognostic factors for survival in patients with CNS metastasis originating from gynecological cancer., Study Design: The present retrospective study analyzed the patients with gynecological cancers who were treated due to CNS metastases between January 1999 and December 2019 at Istanbul University Hospital., Results: Forty-seven patients with CNS metastasis of gynecological origin were included in the study. The median age at the time of CNS metastasis was 59 (range 34-93). The median time from initial cancer diagnosis to CNS metastasis was 24.9 (range: 0-108.2) months. Most patients had epithelial ovarian cancer (EOC) (76.6%), followed by endometrial cancer (EC) (14.8%), cervical cancer (CC) (4.3%), and vulvar cancer (VC) (4.3%). By multivariate analysis, the presence of extracranial metastasis (HR: 5.10; 95% CI: 1.71-15.18), Eastern Cooperative Oncology Group (ECOG) performance status ≥3 (HR: 2.92; 95% CI: 1.36-6.26), palliative care only for the treatment of CNS metastasis (HR: 1.47; 95% CI: 0.58-4.11), and treatment-free interval (TFI) <6 months (HR: 2.74; 95% CI: 1.23-6.08) were independent factors that associated with worse survival., Conclusion: Patients with CNS metastasis who have favorable prognostic factors are considered to be appropriate candidates for aggressive and long-term treatment strategies. Extracranial metastasis, ECOG performance status, treatment history of CNS metastasis, and TFI were determined as independent prognostic factors that improved survival. TFI might be taken into account as a prognostic factor for patients with CNS metastasis in gynecological cancer., (Copyright © 2023 Copyright: © 2023 Journal of Cancer Research and Therapeutics.)
- Published
- 2023
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46. Do Children with Attention Deficit and Hyperactivity Disorder Present with Different Spatio-Temporal Gait Parameters? An Evaluation of the Relationship Between Gait and Gross Motor Skills.
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Demircioğlu A, Atasavun Uysal S, Şanlı Dumankaya BB, Kırdı E, Tuna Çak Esen H, Dağ O, and Topuz S
- Abstract
Objective: The aim of the current study was to compare the spatio-temporal parameters of gait and gross motor skills in children with attention deficit hyperactivity disorder-combined type with those of typically developing children and to search the effect of motor skills on gait parameters in children with attention deficit hyperactivity disorder-combined type., Methods: A total of 50 children (n = 25 attention deficit hyperactivity disorder-combined type, n = 25 typically developing children) aged 5-12 years were included. Gross motor skills were evaluated using the Bruininks-Oseretsky Test Second Edition-Short Form. Spatio-temporal parameters of gait were assessed with a GAITRite
® computer-based system., Results: In the subtests of Bruininks-Oseretsky Test Second Edition-Short Form (bilateral coordination ( P < .001), balance ( P = .013), running speed and agility ( P = .003)), lower scores were obtained by the children with attention deficit hyperactivity disorder-combined type. The swing phase of gait was found to be longer in children with attention deficit hyperactivity disorder-combined type ( P = .01)., Conclusion: The current study results show that gross motor skills are affected negatively and the swing phase is prolonged in children with attention deficit hyperactivity disorder-combined type. Upper limb coordination and balance were also seen to have an effect on the velocity, step, and stride length. It is important to include an objective gait assessment as well as gross motor skills in the comprehensive clinical evaluation of children with attention deficit hyperactivity disorder-combined type., (2023 authors.)- Published
- 2023
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47. The etiology of adnexal masses in women with a history of non-gynaecological malignancy: recurrence, second, primary or none?
- Author
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Yumru Çeliksoy H, Sözen H, Baktıroğlu M, Topuz S, and Salihoğlu Y
- Abstract
Objective: The occurrence of adnexal masses in patients with a history of non-gynaecological malignancy (NGM) raises concerns for malignancy, either primary or metastasis. Subsequent treatment and prognosis depends on the etiology. Our aim was to investigate the characteristics and results of the patients with suspicious adnexal masses, who had a history of NGM., Material and Methods: The records of 61 patients with a history of NGM were analyzed, who were operated for an adnexal mass. Complex adnexal masses were included in the analysis while simple cysts were excluded., Results: The most common NGM origins were gastrointestinal (gastric and colorectal) tract and breast. Of all adnexal masses, four were benign (6.5%), 22 were primary ovarian malignancy (36.1%) and 35 were metastasis (57.4%). Two of the 22 primary cases were borderline ovarian tumor. Among the characteristics of primary and metastatic groups, laterality in pathology results and serum CA125 levels were statistically different (p<0.05). Among the patients with history of gastrointestinal cancers, the percentage of ovarian metastasis was 81%. Primary ovarian malignancy was most frequently (64%) observed among the patients with history of breast cancers., Conclusion: For patients with a history of gastrointestinal cancer, recurrence of the cancer in the form of ovarian metastasis was more likely, rather than a second primary cancer. The risk of primary ovarian cancer (POC) was remarkable in those with history of a breast cancer. A multidisciplinary strategy, including a gynaecological oncologist, plays an important role in managing these cases, regardless of whether or not it is a POC.
- Published
- 2022
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48. Bedside decompression of abdominal compartment syndrome caused by spontaneous pneumoperitoneum: A case report.
- Author
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Topuz S
- Subjects
- Decompression adverse effects, Female, Humans, Laparotomy adverse effects, Middle Aged, Peritoneal Lavage adverse effects, Intra-Abdominal Hypertension etiology, Intra-Abdominal Hypertension surgery, Pneumoperitoneum diagnostic imaging, Pneumoperitoneum etiology, Pneumoperitoneum surgery
- Abstract
Pneumoperitoneum is the presence of free air within the peritoneal cavity and indicates perforation of a hollow viscus. However, it may also occur in the absence of perforation and in this case, it is called spontaneous pneumoperitoneum (SP). A 57-year-old female patient who was intubated and mechanically ventilated due to respiratory failure developed abdominal compartment syndrome (ACS) secondary to massive SP. Peritoneal lavage was performed for the patient both to achieve decompression and to support the diagnosis. Many surgeons proceed with laparotomy as a reflex response for SP due to lack of awareness of the condition. However, laparotomy has no place in this setting. SP coexisting with ACS is extremely rare. With this case report, we aimed to raise awareness of SP among physicians and help avoid unnecessary laparotomies.
- Published
- 2022
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49. Investigation of postural control and spatiotemporal parameters of gait during dual tasks in ataxic individuals.
- Author
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Sütçü G, Doğan M, and Topuz S
- Subjects
- Activities of Daily Living, Cognition physiology, Humans, Ataxia, Gait physiology, Postural Balance physiology
- Abstract
Background: Concurrent cognitive and motor tasks in ataxic individuals cause functional limitations and negatively affect the independence of patients in daily life., Objectives: This study aimed to examine the effects of dual task on postural control and spatiotemporal parameters of gait in ataxic individuals., Methods: The study included 20 individuals with ataxia. Disease severity was evaluated using the International Cooperative Ataxia Rating Scale. A force platform was used to evaluate postural sway and limits of stability and a GAITRite electronic walkway to evaluate the spatiotemporal parameters of gait. Postural control and gait were evaluated without a simultaneous task (task-1) and with dual tasks consisting of counting the names starting with "a selected letter such as A" (task-2), counting backwards aloud in threes from 100 (task-3), carrying a glass of water with a tray (task-4), and speaking on a mobile phone (task-5). The effects of dual task on postural control and gait parameters were examined with multiple comparisons., Results: The tasks requiring cognitive skills (tasks 2, 3, 5) were determined to have a greater effect on the increase of body sway, and gait was seen to be affected by motor and/or cognitive tasks (tasks 2, 4, 5)., Conclusion: From the results of the present study, it is thought that evaluations of postural control and gait performance of ataxic individuals together with the dual tasks they may encounter in daily life are important in terms of their independence in activities of daily living., (© 2022. Fondazione Società Italiana di Neurologia.)
- Published
- 2022
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50. Angiotensin (1-7) peptide replacement therapy with plasma transfusion in COVID-19.
- Author
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Onal H, Ergun NU, Arslan B, Topuz S, Semerci SY, Ugurel OM, Topuzogullari M, Kalkan A, Yoldemir SA, Suner N, and Kocatas A
- Subjects
- Adult, Aged, 80 and over, Angiotensin I, Blood Component Transfusion, Critical Illness, Female, Humans, Male, Oxygen, Peptide Fragments, Plasma, SARS-CoV-2, Treatment Outcome, COVID-19 therapy
- Abstract
Aim: To determine whether convalescent angiotensin (1-7) peptide replacement therapy with plasma (peptide plasma) transfusion can be beneficial in the treatment of critically ill patients with severe coronavirus 2 (SARS-CoV-2) infection., Study Design: Case series of 9 critically ill patients with laboratory-confirmed COVID-19 who met the following criteria: severe pneumonia with rapid progression and continuously high viral load despite antiviral treatment. Peptide plasma: Plasma with angiotensin (1-7) content 8-10 times higher than healthy plasma donors was obtained from suitable donors. Peptide plasma transfusion was applied to 9 patients whose clinical status and/or laboratory profile deteriorated and who needed intensive care for 2 days., Results: In our COVID-19 cases, favipiravir, low molecular weight heparin treatment, which is included in the treatment protocol of the ministry of health, was started. Nine patients with oxygen saturation of 93% and below despite nasal oxygen support, whose clinical and/or laboratory deteriorated, were identified. The youngest of the cases was 36 years old, and the oldest patient was 85 years old. 6 of the 9 cases had male gender. 3 cases had been smoking for more than 10 years. 4 cases had at least one chronic disease. In all of our cases, SARS CoV2 lung involvement was bilateral and peptide plasma therapy was administered in cases when oxygen saturation was 93% and below despite nasal oxygen support of 5 liters/minute and above, and intensive care was required. Although it was not reflected in the laboratory parameters in the early period, 8 patients whose saturations improved with treatment were discharged without the need for intensive care. However, a similar response was not obtained in one case. Oxygen requirement increased gradually and, he died in intensive care process. An increase of the platelet count was observed in all cases following the peptide plasma treatment., Conclusion: In this preliminary case series of 9 critically ill patients with COVID-19, administration of plasma containing angiotensin (1-7) was followed by improvement in their clinical status. The limited sample size and study design preclude a definitive statement about the potential effectiveness of this treatment, and these observations require evaluation in clinical trials., (Copyright © 2022 Elsevier Ltd. All rights reserved.)
- Published
- 2022
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