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Objective: To estimate the incidence of major adverse cardiovascular events (MACE) with genotype test-guided antiplatelet therapy in patients undergoing percutaneous coronary intervention (PCI) for acute coronary syndrome. Methods: Patients who had undergone PCI for acute coronary syndrome as well as stable coronary artery disease were recruited. Salivary samples were obtained from these patients and genotyped for CYP2C19∗2, CYP2C19∗3 variations by sequencing method (GAAP x method). Patients were categorized as normal (GG, GG) (29%), intermediate (AG) (52%) or poor metabolizes (homozygous variant AA) (19%). Dual antiplatelets were given based on the genotyping data. Poor metabolizes received newer agent (ticagrelor), intermediate metabolizes received double-dose of clopidogrel and normal metabolizes received therapeutic doses of clopidogrel. All subjects were followed-up for six months. Results: Based on the genotyping data of CYP2C19∗2 and CYP2C19∗3 variations, it was found that most patients were categorized as ‘intermediate’ (78, 51.65%), followed by ‘normal’ (43, 28.48%) and ‘poor’ metabolizes (30, 19.87%). Only 3 (1.5%) of 151 patients reported MACE at follow-up. Conclusions: Genotyping for CYP2C19 variations to assess clopidogrel resistance in patients undergoing PCI and subsequent drug selection helps reduce MACE after coronary intervention.

The main focus of this research is to enhance the use of eco-friendly materials these days. The current materials used in building construction are chemical-based and are harmful to humans and the environment. This research work has developed a new type of hybrid brick by using natural fibres and waste materials. This research focuses on fabricating novel bricks reinforced with different percentages of coconut waste fibre, wheat straw fibre, waste wood animal dung ash, gypsum, sand, and cement. The fabricated novel brick’s physical, mechanical, chemical, acoustic, and heat-absorbing properties were evaluated.

Pyrolysis is the most important thermochemical process that can be used for the production of biofuel, from wood and wood-based lignocellulosic materials. In this study, bio-oil is produced from the bio-weed named Ficus religiosa by the thermal pyrolysis process by utilizing laboratory-scale fluidized bed reactor. This study deals with the production of maximum bio-oil by optimizing process parameters such as process temperature, particle size, and sweep gas flow rate. Further different analytical techniques were used to describe the properties of bio-oil for different applications. Wood and wood barks of Ficus religiosa were chosen as the raw material due to their higher volatile content (72.4%). The maximum yield of 47.5 wt% bio-oil was collected at the optimized operating conditions of 450°C temperature, 1.0 mm particle size, and 2.0 m3/h sweep gas flow rate. Compared with other operating parameters, temperature is observed as the most significant one to determine the product yield. Through chromatographic analysis, it was identified that the bio-oil is found with the variety of chemical compounds including alcohols, alkenes, phenols, saturated fatty acids, and esters.

Grewia optiva wheat straw waste fibre and PAN fibre are combined in this study to create new composite materials. The novel specimens were created in the hydraulic hind moulding machine with varying percentages of mass of wheat straw fibres, PAN fibre (2–8%) in an equivalent ratio with other materials, and Kevlar fibre-based composites (2–4%). Natural fibre-reinforced clothing is getting increasingly fashionable these days; thus, this research is important. In several papers, natural fibre has been stated to have the potential to replace synthetic fibres. Natural fibre reinforcing has also proven to be quite effective as composites. It is currently used in a range of fields, including medical fields, aerospace, and the automobile industry, among others. Synthetic fibres are used. The usage of synthetic fibres such as asbestos and Kevlar has already been linked to mesothelioma, a kind of lung cancer. Many people have died as a result of Kevlar and asbestos. As a result, an effort to replace these materials is ongoing. Fabricated material’s mechanical, chemical, physical, tribological, and thermal properties were evaluated.

This study deals with the flash pyrolysis of Albizia odoratissima biomass wastes at different temperature, sweep gas flow rate, and heating rate in a fluidized bed reactor. In the first phase of the experimental work, the effect of temperature (350–550°C) on product yield was analyzed, the second and third phases of the work were to analyze the effect of sweeping gas (N2), flow rate (1.25–2.25 m3/hr), and heating rate (20–40°C/min). The experimental works were carried out to get maximum bio-oil production. The experimental results demonstrated that the maximum yield of bio-oil was obtained at a temperature of 450°C, N2 flow rate of 1.75 m3/hr, and heating rate of 30°C/min. Temperature was found to be the crucial factor rather than sweep gas flow rate in the product distribution. Fourier transform infrared spectroscopy (FT-IR), gas chromatography mass spectroscopy (GC-MS), and elemental analysis were done on the obtained bio-oil, biochar, and noncondensable gas products. The heating value of the bio-oil and biochar was identified as 18.15 and 23.47 MJ/kg, respectively. The chemical analysis of the bio-oil showed that the oil is a mixture of phenol and oxygenated elements. The gas analyses showed that hydrogen and carbon dioxide were dominant, followed by carbon monoxide and methane.

The main focus of this research is to enhance the use of eco-friendly materials these days. The current materials used in building construction are chemical-based and are harmful to humans and the environment. This research work has developed a new type of hybrid brick by using natural fibres and waste materials. This research focuses on fabricating novel bricks reinforced with different percentages of coconut waste fibre, wheat straw fibre, waste wood animal dung ash, gypsum, sand, and cement. The fabricated novel brick's physical, mechanical, chemical, acoustic, and heat-absorbing properties were evaluated., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2022 Naresh Kumar et al.)

Objectives: Complementary and Alternate medicine (CAM) remains as the major source of healthcare for majority of the Indian population. This widespread resource needs to be strengthened, adequately trained and effectively utilized in the national health care delivery system for delivering an integrated and effective health care system., Methods: A cross sectional study was conducted involving 200 adults in two different settings-a community setting (n=100), and a hospital setting (n=100). A semi-structured questionnaire was used., Results: Both in the community and in the hospital, siddha (80%) was the most well-known system of medicine, followed by Yoga (72%) and Naturopathy in the study population. However, the knowledge about the various available CAM therapies still seemed to be limited., Conclusions: Opinion on the integrated approach along with conventional medicine was welcoming. Still more awareness about these systems is required to facilitate integrative medicine in healthcare settings., (© 2021 Walter de Gruyter GmbH, Berlin/Boston.)

Objective: To estimate the incidence of major adverse cardiovascular events (MACE) with genotype test-guided antiplatelet therapy in patients undergoing percutaneous coronary intervention (PCI) for acute coronary syndrome., Methods: Patients who had undergone PCI for acute coronary syndrome as well as stable coronary artery disease were recruited. Salivary samples were obtained from these patients and genotyped for CYP2C19∗2, CYP2C19∗3 variations by sequencing method (GAAP x method). Patients were categorized as normal (GG, GG) (29%), intermediate (AG) (52%) or poor metabolizes (homozygous variant AA) (19%). Dual antiplatelets were given based on the genotyping data. Poor metabolizes received newer agent (ticagrelor), intermediate metabolizes received double-dose of clopidogrel and normal metabolizes received therapeutic doses of clopidogrel. All subjects were followed-up for six months., Results: Based on the genotyping data of CYP2C19∗2 and CYP2C19∗3 variations, it was found that most patients were categorized as 'intermediate' (78, 51.65%), followed by 'normal' (43, 28.48%) and 'poor' metabolizes (30, 19.87%). Only 3 (1.5%) of 151 patients reported MACE at follow-up., Conclusions: Genotyping for CYP2C19 variations to assess clopidogrel resistance in patients undergoing PCI and subsequent drug selection helps reduce MACE after coronary intervention., Competing Interests: Declaration of competing interest All authors have none to declare., (Copyright © 2020 Cardiological Society of India. Published by Elsevier B.V. All rights reserved.)