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The Isoxazole ring system belongs to a much studied class of compound. In the last few decades, the chemistry of Isoxazoles and their fused heterocyclic derivatives have received considerable attention owing to their significant and effective biological activity. The present study aimed to design and synthesize novel derivatives of Isoxazole from 4-methoxy aniline gives N-(4-methoxyphenyl) acetamide which was hydrolysis with sodium hydroxide and treated aromatic aldehydes yields resultant compound N-(4-methoxyphenyl) 3-phenyl propanamide (BSM-IIIA-IIIJ). Title compound were synthesized and the structures of newly synthesized compounds were confirmed by IR, Mass and 1H-NMR spectroscopy. All the compounds synthesized were evaluated for their analgesic activity by using Eddy’s hot plate method. The compounds 5- (4-bromophenyl)-N-(4- methoxyphenyl) 4,5- dihydroisoxazole-3-amine (BSM-IIID) and 5- (4-chloro-3-nitrophenyl)-N-(4- methoxyphenyl) 4,5- dihydroisoxazole-3-amine (BSM-IIIF) were shown good analgesic activity and remaining compounds were shown poor analgesic activity.

Coronavirus (covid-19) disease is caused by SARS-COV-2 virus,it is known as severe acute respiratory syndrome coronavirus 2, firstly seen in china in December 2019in human it is characterized by pulmonary infection.The intension of this systematic review was to encapsulate the evidence regarding chloroquine efficacy for the covid -19 treatment. Chloroquine is part of WHO (World health organization) essential medicine model list and it is set clinical safety profile and it is also cheap and has been worldwide used for additionally 70 years.Chloroquine has many activities, one of which is to alkalise the phagolysosome, which hampers the low-pH-dependent steps of viral replication, including uncoating and fusion, In vitro study revealed that Chloroquine is effective at both entry, and at post entry stages of SARS-COV-2 infection in Vero E6 cells. In vitro, chloroquine appears as a versatile bioactive agent reported to possess antiviral activity against RNA viruses as diverse as rabies virus ,Dengue virus , HIV ,hepatitis C virus, hepatitis A virus, poliovirus , influenza A and B viruses, Zika virus, influenza A H5N1 virus, Chikungunya virus , as well as various DNA viruses such as hepatitis B virus and herpes simplex virus.chloroquine is effective in reducing viral replication in other infections , including SARS-associated coronavirus (COV)and MERSCOV.

Coronavirus (covid-19) disease is caused by SARS-COV-2 virus,it is known as severe acute respiratory syndrome coronavirus 2, firstly seen in china in December 2019in human it is characterized by pulmonary infection.The intension of this systematic review was to encapsulate the evidence regarding chloroquine efficacy for the covid -19 treatment. Chloroquine is part of WHO (World health organization) essential medicine model list and it is set clinical safety profile and it is also cheap and has been worldwide used for additionally 70 years.Chloroquine has many activities, one of which is to alkalise the phagolysosome, which hampers the low-pH-dependent steps of viral replication, including uncoating and fusion, In vitro study revealed that Chloroquine is effective at both entry, and at post entry stages of SARS-COV-2 infection in Vero E6 cells. In vitro, chloroquine appears as a versatile bioactive agent reported to possess antiviral activity against RNA viruses as diverse as rabies virus ,Dengue virus , HIV ,hepatitis C virus, hepatitis A virus, poliovirus , influenza A and B viruses, Zika virus, influenza A H5N1 virus, Chikungunya virus , as well as various DNA viruses such as hepatitis B virus and herpes simplex virus.chloroquine is effective in reducing viral replication in other infections , including SARS-associated coronavirus (COV)and MERSCOV.

Background Most of the edible portions like peel and skin of some fruits is discarded while consuming it, though they are rich in several health beneficial phytochemicals or nutrients. Many reports from literature are about fruit pulp of (Sapota) Manilkara zapota (L) P. Royen having high radical scavenging and antioxidant potential, but the studies relating to peel extracts are scanty. Regardless of its commendable phytoconstituents which could have free radical scavenging potential, this fruit peel is as yet still needed to be assessed for in vitro antidiabetic prospects. Hence, the present study aims at evaluating in vitro free radical scavenging and α-glucosidase enzyme hindrance abilities of this fruit peel. Results With a maximum considerable % extractive yield (18.90%) in 70% ethanol, this study has demonstrated that 70% ethanolic extract of Manilkara Zapota (L.) P. Royen Fruit Peel (MZFP) has the highest in vitro free radical scavenging potential as compared to extracts of other solvents viz. n-hexane, chloroform, acetone, absolute ethanol, and water by DPPH and H2O2 assays. In order to optimize the extraction condition parameters, MZFP sample evaluated with three different concentrations of ethanol (40%, 70%, 100%), extraction times (6 h, 9 h, 12 h), and temperatures (40 °C, 50 °C, 60 °C) to get the highest radical scavenging potential. The MZFP when extracted with 70% ethanol, at 50 °C for 12 h, showed higher DPPH (IC50 = 0.34 and 88.42% inhibition at 1 mg/ml) and H2O2 (IC50 = 32.69 and 65.78% inhibition at 50 μg/ml) radical scavenging potential than absolute and 40% ethanolic extracts, when ascorbic acid was used as a reference standard. While further evaluation for in vitro α-glucosidase enzyme inhibition, 70% ethanolic MZFP extract demonstrated high inhibition activity (IC50 = 104.23 ± 1.75 μg/ml) than absolute ethanolic extract (IC50 = 111.65 ± 1.57 μg/ml) with a significant difference (p < 0.05), when acarbose was taken as reference inhibitor (IC50 = 86.93 ± 0.74 μg/ml). Conclusions Overall results indicated that MZFP 70% ethanolic extract exhibited promising in vitro radical scavenging and α-glucosidase enzyme inhibition potential. Thus, suggesting further studies with isolated phytochemicals from peel to explore its potentials for antidiabetic activity through in vitro α-glucosidase enzyme inhibition.