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1. Measurements of neutrino oscillation parameters from the T2K experiment using $$3.6\times 10^{21}$$ 3.6 × 10 21 protons on target

Author: K. Abe, N. Akhlaq, R. Akutsu, A. Ali, S. Alonso Monsalve, C. Alt, C. Andreopoulos, M. Antonova, S. Aoki, T. Arihara, Y. Asada, Y. Ashida, E. T. Atkin, M. Barbi, G. J. Barker, G. Barr, D. Barrow, M. Batkiewicz-Kwasniak, F. Bench, V. Berardi, L. Berns, S. Bhadra, A. Blanchet, A. Blondel, S. Bolognesi, T. Bonus, S. Bordoni, S. B. Boyd, A. Bravar, C. Bronner, S. Bron, A. Bubak, M. Buizza Avanzini, J. A. Caballero, N. F. Calabria, S. Cao, D. Carabadjac, A. J. Carter, S. L. Cartwright, M. G. Catanesi, A. Cervera, J. Chakrani, D. Cherdack, P. S. Chong, G. Christodoulou, A. Chvirova, M. Cicerchia, J. Coleman, G. Collazuol, L. Cook, A. Cudd, C. Dalmazzone, T. Daret, Yu. I. Davydov, A. De Roeck, G. De Rosa, T. Dealtry, C. C. Delogu, C. Densham, A. Dergacheva, F. Di Lodovico, S. Dolan, D. Douqa, T. A. Doyle, O. Drapier, J. Dumarchez, P. Dunne, K. Dygnarowicz, A. Eguchi, S. Emery-Schrenk, G. Erofeev, A. Ershova, G. Eurin, D. Fedorova, S. Fedotov, M. Feltre, A. J. Finch, G. A. Fiorentini Aguirre, G. Fiorillo, M. D. Fitton, J. M. Franco Patiño, M. Friend, Y. Fujii, Y. Fukuda, K. Fusshoeller, L. Giannessi, C. Giganti, V. Glagolev, M. Gonin, J. González Rosa, E. A. G. Goodman, A. Gorin, M. Grassi, M. Guigue, D. R. Hadley, J. T. Haigh, P. Hamacher-Baumann, D. A. Harris, M. Hartz, T. Hasegawa, S. Hassani, N. C. Hastings, Y. Hayato, D. Henaff, A. Hiramoto, M. Hogan, J. Holeczek, A. Holin, T. Holvey, N. T. Hong Van, T. Honjo, F. Iacob, A. K. Ichikawa, M. Ikeda, T. Ishida, M. Ishitsuka, H. T. Israel, K. Iwamoto, A. Izmaylov, N. Izumi, M. Jakkapu, B. Jamieson, S. J. Jenkins, C. Jesús-Valls, J. J. Jiang, P. Jonsson, S. Joshi, C. K. Jung, P. B. Jurj, M. Kabirnezhad, A. C. Kaboth, T. Kajita, H. Kakuno, J. Kameda, S. P. Kasetti, Y. Kataoka, Y. Katayama, T. Katori, M. Kawaue, E. Kearns, M. Khabibullin, A. Khotjantsev, T. Kikawa, H. Kikutani, S. King, V. Kiseeva, J. Kisiel, T. Kobata, H. Kobayashi, T. Kobayashi, L. Koch, S. Kodama, A. Konaka, L. L. Kormos, Y. Koshio, A. Kostin, T. Koto, K. Kowalik, Y. Kudenko, Y. Kudo, S. Kuribayashi, R. Kurjata, T. Kutter, M. Kuze, M. La Commara, L. Labarga, K. Lachner, J. Lagoda, S. M. Lakshmi, M. Lamers James, M. Lamoureux, A. Langella, J.-F. Laporte, D. Last, N. Latham, M. Laveder, L. Lavitola, M. Lawe, Y. Lee, C. Lin, S.-K. Lin, R. P. Litchfield, S. L. Liu, W. Li, A. Longhin, K. R. Long, A. Lopez Moreno, L. Ludovici, X. Lu, T. Lux, L. N. Machado, L. Magaletti, K. Mahn, M. Malek, M. Mandal, S. Manly, A. D. Marino, L. Marti-Magro, D. G. R. Martin, M. Martini, J. F. Martin, T. Maruyama, T. Matsubara, V. Matveev, C. Mauger, K. Mavrokoridis, E. Mazzucato, N. McCauley, J. McElwee, K. S. McFarland, C. McGrew, J. McKean, A. Mefodiev, G. D. Megias, P. Mehta, L. Mellet, C. Metelko, M. Mezzetto, E. Miller, A. Minamino, O. Mineev, S. Mine, M. Miura, L. Molina Bueno, S. Moriyama, P. Morrison, Th. A. Mueller, D. Munford, L. Munteanu, K. Nagai, Y. Nagai, T. Nakadaira, K. Nakagiri, M. Nakahata, Y. Nakajima, A. Nakamura, H. Nakamura, K. Nakamura, K. D. Nakamura, Y. Nakano, S. Nakayama, T. Nakaya, K. Nakayoshi, C. E. R. Naseby, T. V. Ngoc, V. Q. Nguyen, K. Niewczas, S. Nishimori, Y. Nishimura, K. Nishizaki, T. Nosek, F. Nova, P. Novella, J. C. Nugent, H. M. O’Keeffe, L. O’Sullivan, T. Odagawa, T. Ogawa, R. Okada, W. Okinaga, K. Okumura, T. Okusawa, N. Ospina, R. A. Owen, Y. Oyama, V. Palladino, V. Paolone, M. Pari, J. Parlone, S. Parsa, J. Pasternak, M. Pavin, D. Payne, G. C. Penn, D. Pershey, L. Pickering, C. Pidcott, G. Pintaudi, C. Pistillo, B. Popov, K. Porwit, M. Posiadala-Zezula, Y. S. Prabhu, F. Pupilli, B. Quilain, T. Radermacher, E. Radicioni, B. Radics, M. A. Ramírez, P. N. Ratoff, M. Reh, C. Riccio, E. Rondio, S. Roth, N. Roy, A. Rubbia, A. C. Ruggeri, C. A. Ruggles, A. Rychter, K. Sakashita, F. Sánchez, G. Santucci, C. M. Schloesser, K. Scholberg, M. Scott, Y. Seiya, T. Sekiguchi, H. Sekiya, D. Sgalaberna, A. Shaikhiev, F. Shaker, A. Shaykina, M. Shiozawa, W. Shorrock, A. Shvartsman, N. Skrobova, K. Skwarczynski, D. Smyczek, M. Smy, J. T. Sobczyk, H. Sobel, F. J. P. Soler, Y. Sonoda, A. J. Speers, R. Spina, I. A. Suslov, S. Suvorov, A. Suzuki, S. Y. Suzuki, Y. Suzuki, A. A. Sztuc, M. Tada, S. Tairafune, S. Takayasu, A. Takeda, Y. Takeuchi, K. Takifuji, H. K. Tanaka, Y. Tanihara, M. Tani, A. Teklu, V. V. Tereshchenko, N. Teshima, N. Thamm, L. F. Thompson, W. Toki, C. Touramanis, T. Towstego, K. M. Tsui, T. Tsukamoto, M. Tzanov, Y. Uchida, M. Vagins, D. Vargas, M. Varghese, G. Vasseur, C. Vilela, E. Villa, W. G. S. Vinning, U. Virginet, T. Vladisavljevic, T. Wachala, J. G. Walsh, Y. Wang, L. Wan, D. Wark, M. O. Wascko, A. Weber, R. Wendell, M. J. Wilking, C. Wilkinson, J. R. Wilson, K. Wood, C. Wret, J. Xia, Y.-H. Xu, K. Yamamoto, T. Yamamoto, C. Yanagisawa, G. Yang, T. Yano, K. Yasutome, N. Yershov, U. Yevarouskaya, M. Yokoyama, Y. Yoshimoto, N. Yoshimura, M. Yu, R. Zaki, A. Zalewska, J. Zalipska, K. Zaremba, G. Zarnecki, X. Zhao, T. Zhu, M. Ziembicki, E. D. Zimmerman, M. Zito, S. Zsoldos, and T2K Collaboration
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract The T2K experiment presents new measurements of neutrino oscillation parameters using $$19.7(16.3)\times 10^{20}$$ 19.7 ( 16.3 ) × 10 20 protons on target (POT) in (anti-)neutrino mode at the far detector (FD). Compared to the previous analysis, an additional $$4.7\times 10^{20}$$ 4.7 × 10 20 POT neutrino data was collected at the FD. Significant improvements were made to the analysis methodology, with the near-detector analysis introducing new selections and using more than double the data. Additionally, this is the first T2K oscillation analysis to use NA61/SHINE data on a replica of the T2K target to tune the neutrino flux model, and the neutrino interaction model was improved to include new nuclear effects and calculations. Frequentist and Bayesian analyses are presented, including results on $$\sin ^2\theta _{13}$$ sin 2 θ 13 and the impact of priors on the $$\delta _{\textrm{CP}}$$ δ CP measurement. Both analyses prefer the normal mass ordering and upper octant of $$\sin ^2\theta _{23}$$ sin 2 θ 23 with a nearly maximally CP-violating phase. Assuming the normal ordering and using the constraint on $$\sin ^2\theta _{13}$$ sin 2 θ 13 from reactors, $$\sin ^2\theta _{23}=0.561^{+0.021}_{-0.032}$$ sin 2 θ 23 = 0 . 561 - 0.032 + 0.021 using Feldman–Cousins corrected intervals, and $$\varDelta {}m^2_{32}=2.494_{-0.058}^{+0.041}\times 10^{-3}~\text {eV}^2$$ Δ m 32 2 = 2 . 494 - 0.058 + 0.041 × 10 - 3 eV 2 using constant $$\varDelta \chi ^{2}$$ Δ χ 2 intervals. The CP-violating phase is constrained to $$\delta _{\textrm{CP}}=-1.97_{-0.70}^{+0.97}$$ δ CP = - 1 . 97 - 0.70 + 0.97 using Feldman–Cousins corrected intervals, and $$\delta _{\textrm{CP}}=0,\pi $$ δ CP = 0 , π is excluded at more than 90% confidence level. A Jarlskog invariant of zero is excluded at more than $$2\sigma $$ 2 σ credible level using a flat prior in $$\delta _{\textrm{CP}},$$ δ CP , and just below $$2\sigma $$ 2 σ using a flat prior in $$\sin \delta _{\textrm{CP}}.$$ sin δ CP . When the external constraint on $$\sin ^2\theta _{13}$$ sin 2 θ 13 is removed, $$\sin ^2\theta _{13}=28.0^{+2.8}_{-6.5}\times 10^{-3},$$ sin 2 θ 13 = 28 . 0 - 6.5 + 2.8 × 10 - 3 , in agreement with measurements from reactor experiments. These results are consistent with previous T2K analyses.
Published: 2023
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2. DEEPLIO: DEEP LIDAR INERTIAL SENSOR FUSION FOR ODOMETRY ESTIMATION

Author: A. Javanmard-Gh., D. Iwaszczuk, and S. Roth
Subjects: Technology, Engineering (General). Civil engineering (General), TA1-2040, Applied optics. Photonics, TA1501-1820
Abstract: Having a good estimate of the position and orientation of a mobile agent is essential for many application domains such as robotics, autonomous driving, and virtual and augmented reality. In particular, when using LiDAR and IMU sensors as the inputs, most existing methods still use classical filter-based fusion methods to achieve this task. In this work, we propose DeepLIO, a modular, end-to-end learning-based fusion framework for odometry estimation using LiDAR and IMU sensors. For this task, our network learns an appropriate fusion function by considering different modalities of its input latent feature vectors. We also formulate a loss function, where we combine both global and local pose information over an input sequence to improve the accuracy of the network predictions. Furthermore, we design three sub-networks with different modules and architectures derived from DeepLIO to analyze the effect of each sensory input on the task of odometry estimation. Experiments on the benchmark dataset demonstrate that DeepLIO outperforms existing learning-based and model-based methods regarding orientation estimation and shows a marginal position accuracy difference.
Published: 2021
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3. Hidden bulk and surface effects in the spin polarization of the nodal-line semimetal ZrSiTe

Author: G. Gatti, D. Gosálbez-Martínez, S. Roth, M. Fanciulli, M. Zacchigna, M. Kalläne, K. Rossnagel, C. Jozwiak, A. Bostwick, E. Rotenberg, A. Magrez, H. Berger, I. Vobornik, J. Fujii, O. V. Yazyev, M. Grioni, and A. Crepaldi
Subjects: Astrophysics, QB460-466, Physics, QC1-999
Abstract: Local inversion symmetry breaking in centrosymmetric materials can lead to large spin polarization of the electronic band structure in separate sectors of the unit cell. Here, the authors reveal such hidden spin polarisation in ZrSiTe using spin and angle resolved photoemission spectroscopy in combination with ab initio band structure calculations and investigate the resultant spin polarised bulk and surface properties
Published: 2021
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4. Measurement of the charged-current electron (anti-)neutrino inclusive cross-sections at the T2K off-axis near detector ND280

Author: The T2K collaboration, K. Abe, N. Akhlaq, R. Akutsu, A. Ali, C. Alt, C. Andreopoulos, L. Anthony, M. Antonova, S. Aoki, A. Ariga, T. Arihara, Y. Asada, Y. Ashida, E. T. Atkin, Y. Awataguchi, S. Ban, M. Barbi, G. J. Barker, G. Barr, D. Barrow, C. Barry, M. Batkiewicz-Kwasniak, A. Beloshapkin, F. Bench, V. Berardi, L. Berns, S. Bhadra, S. Bienstock, A. Blondel, S. Bolognesi, T. Bonus, B. Bourguille, S. B. Boyd, D. Brailsford, A. Bravar, D. Bravo Berguño, C. Bronner, S. Bron, A. Bubak, M. Buizza Avanzini, J. Calcutt, T. Campbell, S. Cao, S. L. Cartwright, M. G. Catanesi, A. Cervera, A. Chappell, C. Checchia, D. Cherdack, N. Chikuma, G. Christodoulou, M. Cicerchia, J. Coleman, G. Collazuol, L. Cook, D. Coplowe, A. Cudd, A. Dabrowska, G. De Rosa, T. Dealtry, P. F. Denner, S. R. Dennis, C. Densham, F. Di Lodovico, N. Dokania, S. Dolan, T. A. Doyle, O. Drapier, J. Dumarchez, P. Dunne, A. Eguchi, L. Eklund, S. Emery-Schrenk, A. Ereditato, P. Fernandez, T. Feusels, A. J. Finch, G. A. Fiorentini, G. Fiorillo, C. Francois, M. Friend, Y. Fujii, R. Fujita, D. Fukuda, R. Fukuda, Y. Fukuda, K. Fusshoeller, C. Giganti, T. Golan, M. Gonin, A. Gorin, M. Guigue, D. R. Hadley, J. T. Haigh, P. Hamacher-Baumann, M. Hartz, T. Hasegawa, S. Hassani, N. C. Hastings, T. Hayashino, Y. Hayato, A. Hiramoto, M. Hogan, J. Holeczek, N. T. Hong Van, T. Honjo, F. Iacob, A. K. Ichikawa, M. Ikeda, T. Ishida, T. Ishii, M. Ishitsuka, K. Iwamoto, A. Izmaylov, N. Izumi, M. Jakkapu, B. Jamieson, S. J. Jenkins, C. Jesús-Valls, M. Jiang, S. Johnson, P. Jonsson, C. K. Jung, X. Junjie, P. B. Jurj, M. Kabirnezhad, A. C. Kaboth, T. Kajita, H. Kakuno, J. Kameda, D. Karlen, S. P. Kasetti, Y. Kataoka, Y. Katayama, T. Katori, Y. Kato, E. Kearns, M. Khabibullin, A. Khotjantsev, T. Kikawa, H. Kikutani, H. Kim, S. King, J. Kisiel, A. Knight, A. Knox, T. Kobata, T. Kobayashi, L. Koch, T. Koga, A. Konaka, L. L. Kormos, Y. Koshio, A. Kostin, K. Kowalik, H. Kubo, Y. Kudenko, N. Kukita, S. Kuribayashi, R. Kurjata, T. Kutter, M. Kuze, L. Labarga, J. Lagoda, M. Lamoureux, D. Last, M. Laveder, M. Lawe, M. Licciardi, T. Lindner, R. P. Litchfield, S. L. Liu, X. Li, A. Longhin, L. Ludovici, X. Lu, T. Lux, L. N. Machado, L. Magaletti, K. Mahn, M. Malek, S. Manly, L. Maret, A. D. Marino, L. Marti-Magro, J. F. Martin, T. Maruyama, T. Matsubara, K. Matsushita, V. Matveev, C. Mauger, K. Mavrokoridis, E. Mazzucato, M. McCarthy, N. McCauley, J. McElwee, K. S. McFarland, C. McGrew, A. Mefodiev, C. Metelko, M. Mezzetto, A. Minamino, O. Mineev, S. Mine, M. Miura, L. Molina Bueno, S. Moriyama, J. Morrison, Th. A. Mueller, L. Munteanu, S. Murphy, Y. Nagai, T. Nakadaira, M. Nakahata, Y. Nakajima, A. Nakamura, K. G. Nakamura, K. Nakamura, Y. Nakano, S. Nakayama, T. Nakaya, K. Nakayoshi, C. Nantais, C. E. R. Naseby, T. V. Ngoc, K. Niewczas, K. Nishikawa, Y. Nishimura, E. Noah, T. S. Nonnenmacher, F. Nova, P. Novella, J. Nowak, J. C. Nugent, H. M. O’Keeffe, L. O’Sullivan, T. Odagawa, T. Ogawa, R. Okada, K. Okumura, T. Okusawa, S. M. Oser, R. A. Owen, Y. Oyama, V. Palladino, J. L. Palomino, V. Paolone, M. Pari, W. C. Parker, S. Parsa, J. Pasternak, P. Paudyal, M. Pavin, D. Payne, G. C. Penn, L. Pickering, C. Pidcott, G. Pintaudi, E. S. Pinzon Guerra, C. Pistillo, B. Popov, K. Porwit, M. Posiadala-Zezula, A. Pritchard, B. Quilain, T. Radermacher, E. Radicioni, B. Radics, P. N. Ratoff, E. Reinherz-Aronis, C. Riccio, E. Rondio, S. Roth, A. Rubbia, A. C. Ruggeri, C. A. Ruggles, A. Rychter, K. Sakashita, F. Sánchez, G. Santucci, C. M. Schloesser, K. Scholberg, J. Schwehr, M. Scott, Y. Seiya, T. Sekiguchi, H. Sekiya, D. Sgalaberna, R. Shah, A. Shaikhiev, F. Shaker, A. Shaykina, M. Shiozawa, W. Shorrock, A. Shvartsman, A. Smirnov, M. Smy, J. T. Sobczyk, H. Sobel, F. J. P. Soler, Y. Sonoda, J. Steinmann, S. Suvorov, A. Suzuki, S. Y. Suzuki, Y. Suzuki, A. A. Sztuc, M. Tada, M. Tajima, A. Takeda, Y. Takeuchi, H. K. Tanaka, H. A. Tanaka, S. Tanaka, Y. Tanihara, M. Tani, N. Teshima, L. F. Thompson, W. Toki, C. Touramanis, T. Towstego, K. M. Tsui, T. Tsukamoto, M. Tzanov, Y. Uchida, M. Vagins, S. Valder, Z. Vallari, D. Vargas, G. Vasseur, C. Vilela, W. G. S. Vinning, T. Vladisavljevic, V. V. Volkov, T. Wachala, J. Walker, J. G. Walsh, Y. Wang, D. Wark, M. O. Wascko, A. Weber, R. Wendell, M. J. Wilking, C. Wilkinson, J. R. Wilson, R. J. Wilson, K. Wood, C. Wret, Y. Yamada, K. Yamamoto, C. Yanagisawa, G. Yang, T. Yano, K. Yasutome, S. Yen, N. Yershov, M. Yokoyama, T. Yoshida, M. Yu, A. Zalewska, J. Zalipska, K. Zaremba, G. Zarnecki, M. Ziembicki, E. D. Zimmerman, M. Zito, S. Zsoldos, and A. Zykova
Subjects: Other experiments, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract The electron (anti-)neutrino component of the T2K neutrino beam constitutes the largest background in the measurement of electron (anti-)neutrino appearance at the far detector. The electron neutrino scattering is measured directly with the T2K off-axis near detector, ND280. The selection of the electron (anti-)neutrino events in the plastic scintillator target from both neutrino and anti-neutrino mode beams is discussed in this paper. The flux integrated single differential charged-current inclusive electron (anti-)neutrino cross-sections, dσ/dp and dσ/d cos(θ), and the total cross-sections in a limited phase-space in momentum and scattering angle (p > 300 MeV/c and θ ≤ 45°) are measured using a binned maximum likelihood fit and compared to the neutrino Monte Carlo generator predictions, resulting in good agreement.
Published: 2020
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5. LR-CNN: LOCAL-AWARE REGION CNN FOR VEHICLE DETECTION IN AERIAL IMAGERY

Author: W. Liao, X. Chen, J. Yang, S. Roth, M. Goesele, M. Y. Yang, and B. Rosenhahn
Subjects: Technology, Engineering (General). Civil engineering (General), TA1-2040, Applied optics. Photonics, TA1501-1820
Abstract: State-of-the-art object detection approaches such as Fast/Faster R-CNN, SSD, or YOLO have difficulties detecting dense, small targets with arbitrary orientation in large aerial images. The main reason is that using interpolation to align RoI features can result in a lack of accuracy or even loss of location information. We present the Local-aware Region Convolutional Neural Network (LR-CNN), a novel two-stage approach for vehicle detection in aerial imagery. We enhance translation invariance to detect dense vehicles and address the boundary quantization issue amongst dense vehicles by aggregating the high-precision RoIs’ features. Moreover, we resample high-level semantic pooled features, making them regain location information from the features of a shallower convolutional block. This strengthens the local feature invariance for the resampled features and enables detecting vehicles in an arbitrary orientation. The local feature invariance enhances the learning ability of the focal loss function, and the focal loss further helps to focus on the hard examples. Taken together, our method better addresses the challenges of aerial imagery. We evaluate our approach on several challenging datasets (VEDAI, DOTA), demonstrating a significant improvement over state-of-the-art methods. We demonstrate the good generalization ability of our approach on the DLR 3K dataset.
Published: 2020
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6. Off-Axis Characterisation of the CERN T10 Beam for low Momentum Proton Measurements with a High Pressure Gas Time Projection Chamber

Author: S.B. Jones, T.S. Nonnenmacher, E. Atkin, G.J. Barker, A. Basharina-Freshville, C. Betancourt, S.B. Boyd, D. Brailsford, Z. Chen-Wishart, L. Cremonesi, A. Deisting, A. Dias, P. Dunne, J. Haigh, P. Hamacher-Baumann, A. Kaboth, A. Korzenev, W. Ma, P. Mermod, M. Mironova, J. Monroe, R. Nichol, J. Nowak, W. Parker, H. Ritchie-Yates, S. Roth, R. Saakyan, N. Serra, Y. Shitov, J. Steinmann, A. Tarrant, M.A. Uchida, S. Valder, A.V. Waldron, M. Ward, and M.O. Wascko
Subjects: neutrino physics, time projection chamber, high pressure, CERN, beam test, time of flight, Physics, QC1-999, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: We present studies of proton fluxes in the T10 beamline at CERN. A prototype high pressure gas time projection chamber (TPC) was exposed to the beam of protons and other particles, using the 0.8 GeV/c momentum setting in T10, in order to make cross section measurements of low energy protons in argon. To explore the energy region comparable to hadrons produced by GeV-scale neutrino interactions at oscillation experiments, i.e., near 0.1 GeV of kinetic energy, methods of moderating the T10 beam were employed: the dual technique of moderating the beam with acrylic blocks and measuring scattered protons off the beam axis was used to decrease the kinetic energy of incident protons, as well as change the proton/minimum ionising particle (MIP) composition of the incident flux. Measurements of the beam properties were made using time of flight systems upstream and downstream of the TPC. The kinetic energy of protons reaching the TPC was successfully changed from ∼0.3 GeV without moderator blocks to less than 0.1 GeV with four moderator blocks (40 cm path length). The flux of both protons and MIPs off the beam axis was increased. The ratio of protons to MIPs vary as a function of the off-axis angle allowing for possible optimisation of the detector to select the type of required particles. Simulation informed by the time of flight measurements show that with four moderator blocks placed in the beamline, (5.6 ± 0.1) protons with energies below 0.1 GeV per spill traversed the active TPC region. Measurements of the beam composition and energy are presented.
Published: 2020
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7. The Pulse Azimuth effect as seen in induction coil magnetometers located in California and Peru 2007–2010, and its possible association with earthquakes

Author: J. C. Dunson, T. E. Bleier, S. Roth, J. Heraud, C. H. Alvarez, and A. Lira
Subjects: Environmental technology. Sanitary engineering, TD1-1066, Geography. Anthropology. Recreation, Environmental sciences, GE1-350, Geology, QE1-996.5
Abstract: The QuakeFinder network of magnetometers has recorded geomagnetic field activity in California since 2000. Established as an effort to follow up observations of ULF activity reported from before and after the M = 7.1 Loma Prieta earthquake in 1989 by Stanford University, the QuakeFinder network has over 50 sites, fifteen of which are high-resolution QF1005 and QF1007 systems. Pairs of high-resolution sites have also been installed in Peru and Taiwan. Increases in pulse activity preceding nearby seismic events are followed by decreases in activity afterwards in the three cases that are discussed here. In addition, longer term data is shown, revealing a rich signal structure not previously known in QuakeFinder data, or by many other authors who have reported on pre-seismic ULF phenomena. These pulses occur as separate ensembles, with demonstrable repeatability and uniqueness across a number of properties such as waveform, angle of arrival, amplitude, and duration. Yet they appear to arrive with exponentially distributed inter-arrival times, which indicates a Poisson process rather than a periodic, i.e., stationary process. These pulses were observed using three-axis induction coil magnetometers that are buried 1–2 m under the surface of the Earth. Our sites use a Nyquist frequency of 16 Hertz (25 Hertz for the new QF1007 units), and they record these pulses at amplitudes from 0.1 to 20 nano-Tesla with durations of 0.1 to 12 s. They are predominantly unipolar pulses, which may imply charge migration, and they are stronger in the two horizontal (north-south and east-west) channels than they are in the vertical channels. Pulses have been seen to occur in bursts lasting many hours. The pulses have large amplitudes and study of the three-axis data shows that the amplitude ratios of the pulses taken from pairs of orthogonal coils is stable across the bursts, suggesting a similar source. This paper presents three instances of increases in pulse activity in the 30 days prior to an earthquake, which are each followed by steep declines after the event. The pulses are shown, methods of detecting the pulses and calculating their azimuths is developed and discussed, and then the paper is closed with a brief look at future work.
Published: 2011
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8. Silent Spontaneous Uterine Rupture at 36 Weeks of Gestation

Author: J. Y. Woo, L. Tate, S. Roth, and A. C. Eke
Subjects: Gynecology and obstetrics, RG1-991
Abstract: Introduction. Silent spontaneous rupture of the uterus before term, with extrusion of an intact amniotic sac and delivery of a healthy neonate, with no maternal or neonatal morbidity or mortality is very rare. Very few cases have been reported in literature. Case Presentation. We report a case of silent spontaneous uterine rupture, found during a scheduled repeat cesarean section at 36 weeks of gestation. Patient had history of two prior classical cesarean sections. She underwent cesarean section, with delivery of a healthy male infant. She had a good postoperative recovery and was discharged on postoperative day 3. Conclusion. Silent spontaneous rupture of the uterus before term with extrusion of an intact amniotic sac is rare. A high index of suspicion and good imaging during pregnancy are important in making this diagnosis.
Published: 2015
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9. P5.12 CAROTID-FEMORAL AND BRACHIAL PULSE WAVE VELOCITY IN PERIPHERAL ARTERIAL DISEASE

Author: M. Frick, V. Jacomella, S. Roth, I. Wilkinson, B. Amann-Vesti, and M. Husmann
Subjects: Specialties of internal medicine, RC581-951, Diseases of the circulatory (Cardiovascular) system, RC666-701
Published: 2014
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10. An outreach activity to enhance biochemistry pedagogy

Author: Karl S. Roth, Tammy Bannerman, and Venkat Gopalan
Subjects: Molecular Biology, Biochemistry
Published: 2023

11. The Combination of Trametinib and Ganitumab is Effective in RAS-Mutated PAX-Fusion Negative Rhabdomyosarcoma Models

Author: Katie E. Hebron, Xiaolin Wan, Jacob S. Roth, David J. Liewehr, Nancy E. Sealover, William J.E. Frye, Angela Kim, Stacey Stauffer, Olivia L. Perkins, Wenyue Sun, Kristine A. Isanogle, Christina M. Robinson, Amy James, Parirokh Awasthi, Priya Shankarappa, Xiaoling Luo, Haiyan Lei, Donna Butcher, Roberta Smith, Elijah F. Edmondson, Jin-Qiu Chen, Noemi Kedei, Cody J. Peer, Jack F. Shern, W. Douglas Figg, Lu Chen, Matthew D. Hall, Simone Difilippantonio, Frederic G. Barr, Robert L. Kortum, Robert W. Robey, Angelina V. Vaseva, Javed Khan, and Marielle E. Yohe
Subjects: Cancer Research, Oncology
Abstract: Purpose: PAX-fusion negative rhabdomyosarcoma (FN RMS) is driven by alterations in the RAS/MAP kinase pathway and is partially responsive to MEK inhibition. Overexpression of IGF1R and its ligands is also observed in FN RMS. Preclinical and clinical studies have suggested that IGF1R is itself an important target in FN RMS. Our previous studies revealed preclinical efficacy of the MEK1/2 inhibitor, trametinib, and an IGF1R inhibitor, BMS-754807, but this combination was not pursued clinically due to intolerability in preclinical murine models. Here, we sought to identify a combination of an MEK1/2 inhibitor and IGF1R inhibitor, which would be tolerated in murine models and effective in both cell line and patient-derived xenograft models of RAS-mutant FN RMS. Experimental Design: Using proliferation and apoptosis assays, we studied the factorial effects of trametinib and ganitumab (AMG 479), a mAb with specificity for human and murine IGF1R, in a panel of RAS-mutant FN RMS cell lines. The molecular mechanism of the observed synergy was determined using conventional and capillary immunoassays. The efficacy and tolerability of trametinib/ganitumab was assessed using a panel of RAS-mutated cell-line and patient-derived RMS xenograft models. Results: Treatment with trametinib and ganitumab resulted in synergistic cellular growth inhibition in all cell lines tested and inhibition of tumor growth in four of six models of RAS-mutant RMS. The combination had little effect on body weight and did not produce thrombocytopenia, neutropenia, or hyperinsulinemia in tumor-bearing SCID beige mice. Mechanistically, ganitumab treatment prevented the phosphorylation of AKT induced by MEK inhibition alone. Therapeutic response to the combination was observed in models without a mutation in the PI3K/PTEN axis. Conclusions: We demonstrate that combined trametinib and ganitumab is effective in a genomically diverse panel of RAS-mutated FN RMS preclinical models. Our data also show that the trametinib/ganitumab combination likely has a favorable tolerability profile. These data support testing this combination in a phase I/II clinical trial for pediatric patients with relapsed or refractory RAS-mutated FN RMS.
Published: 2022

12. Bedeutung von intraoperativer Gefrierschnittanalyse und histopathologischen Ergebnissen von Wächterlymphknotenbiopsien: Vergleich von Z0011-Studie-geeigneten mit ungeeigneten Brustkrebspatientinnen

Author: Florian Reinhardt, Anna Fiedler, Felix Borgmeier, Petra Reinecke, Irene Esposito, Katalin Mattes-György, Mardjan Dabir, Verena Friebe, Natalia Krawczyk, Thomas Kaleta, Jürgen Hoffmann, Eugen Ruckhäberle, Tanja Fehm, Katrin S. Roth, and Svjetlana Mohrmann
Subjects: General Medicine
Abstract: Zusammenfassung Hintergrund Nach der Veröffentlichung der American College of Surgeons Oncology Group Z0011-Studie (ACOSOG Z0011) ist die Analyse der intraoperativen Gefrierschnitte von Wächterlymphknoten zurückgegangen. Aber für Patientinnen, welche die ACOSOG Z0011-Kriterien nicht erfüllen, bleibt die Gefrierschnittanalyse ein wichtiges Instrument für die intraoperative Entscheidungsfindung im Hinblick auf eine Axilladissektion. Ziel dieser Studie war es, eine retrospektive Evaluierung der Vorteile und der diagnostischen Genauigkeit von Gefrierschnittanalysen bei Brustkrebspatientinnen durchzuführen, welche die Kriterien der Z0011-Studie erfüllten oder nicht erfüllten, und dabei mögliche prädiktive Faktoren für falsch negative Ergebnisse festzustellen. Methoden Zwischen 2008 und 2013 wurde eine intraoperative Gefrierschnittanalyse der Wächterlymphknoten bei 522 cT1-T3-Brustkrebspatientinnen durchgeführt. Die klinisch-pathologischen Merkmale wurden retrospektiv mithilfe der Krankenakten evaluiert. Ergebnisse Insgesamt betrug die Sensitivität und Spezifität für alle Gefrierschnittanalysen 67,8 % bzw. 100 %. Generell war die Sensitivität für Makrometastasen höher als für Mikrometastasen. Bei der Gruppe, welche die Kriterien der Z0011-Studie erfüllte, betrugen die Sensitivität und Spezifität 72,7 % bzw. 100 %, verglichen mit 62,1 % bzw. 100 % für die Gruppe, welche die Z0011-Kriterien nicht erfüllte. In der Gruppe, welche die Z0011-Kriterien erfüllte, wurde eine Untergruppenanalyse durchgeführt, und die Ergebnisse für ≤ 2 positiven Wächterlymphknoten wurden mit den Ergebnissen für > 2 verglichen. Bei beiden Untergruppen betrugen Spezifität und Sensitivität jeweils 100 %. In der Patientinnengruppe, welche die Z0011-Kriterien nicht erfüllte, waren mehrere klinisch-pathologische Faktoren mit einer höheren Rate an falsch positiven Ergebnissen assoziiert. Im Hinblick auf die intraoperative Entscheidungsfindung für eine Axilladissektion brachte die Durchführung einer intraoperativen Gefrierschnittanalyse Vorteile für 22,2 % der Patientinnen, welche die Z0011-Kriterien nicht erfüllten, aber nur für 0,6 % der Patientinnen, welche die Z0011-Kriterien erfüllten. Schlussfolgerungen Die Gefrierschnittanalyse ist besonders für die intraoperative Evaluierung von Wächterlymphknoten bei Patientinnen, welche die Z0011-Kriterien nicht erfüllen, vorteilhaft, da dadurch eine Zweitoperation zur Axilladissektion vermieden werden kann. Obwohl die Sensitivität der Gefrierschnittanalyse in der Gruppe, welche die Z0011-Kriterien erfüllte, insgesamt niedriger war, hat die Gefrierschnittanalyse in beiden Gruppen eine vergleichbar hohe Sensitivität und diagnostische Genauigkeit für Makrometastasen.
Published: 2022

13. Warming and grazing independently and interactively impact plant defenses and palatability

Author: Jamila S. Roth, Todd Z. Osborne, and Laura K. Reynolds
Subjects: Ecology, Evolution, Behavior and Systematics
Published: 2023

14. Comparative long-term effectiveness between ventral hernia repairs with biosynthetic and synthetic mesh

Author: Benjamin G. Morrison, Kiah Gledhill, Margaret A. Plymale, Daniel L. Davenport, and John S. Roth
Subjects: Surgery
Published: 2023

15. Supplementary Table from SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk

Author: Nicolas Reynoird, Nima Mosammaparast, Pawel K. Mazur, Pierre Hainaut, Michiel Vermeulen, Yohann Couté, Pascal W.T.C. Jansen, Marianne Tardif, Rebecca Rodell, Jessica Vayr, Ana Morales Benitez, Florent Chuffart, Alexandre G. Casanova, Joshua R. Brickner, Ning Tsao, Tanveer Ahmad, Clement Oyeniran, Gael S. Roth, Simone Hausmann, and Valentina Lukinović
Abstract: Supplementary Table from SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk
Published: 2023

16. Data from SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk

Author: Nicolas Reynoird, Nima Mosammaparast, Pawel K. Mazur, Pierre Hainaut, Michiel Vermeulen, Yohann Couté, Pascal W.T.C. Jansen, Marianne Tardif, Rebecca Rodell, Jessica Vayr, Ana Morales Benitez, Florent Chuffart, Alexandre G. Casanova, Joshua R. Brickner, Ning Tsao, Tanveer Ahmad, Clement Oyeniran, Gael S. Roth, Simone Hausmann, and Valentina Lukinović
Abstract: Small cell lung cancer (SCLC) is the most fatal form of lung cancer, with dismal survival, limited therapeutic options, and rapid development of chemoresistance. We identified the lysine methyltransferase SMYD3 as a major regulator of SCLC sensitivity to alkylation-based chemotherapy. RNF113A methylation by SMYD3 impairs its interaction with the phosphatase PP4, controlling its phosphorylation levels. This cross-talk between posttranslational modifications acts as a key switch in promoting and maintaining RNF113A E3 ligase activity, essential for its role in alkylation damage response. In turn, SMYD3 inhibition restores SCLC vulnerability to alkylating chemotherapy. Our study sheds light on a novel role of SMYD3 in cancer, uncovering this enzyme as a mediator of alkylation damage sensitivity and providing a rationale for small-molecule SMYD3 inhibition to improve responses to established chemotherapy.Significance:SCLC rapidly becomes resistant to conventional chemotherapy, leaving patients with no alternative treatment options. Our data demonstrate that SMYD3 upregulation and RNF113A methylation in SCLC are key mechanisms that control the alkylation damage response. Notably, SMYD3 inhibition sensitizes cells to alkylating agents and promotes sustained SCLC response to chemotherapy.This article is highlighted in the In This Issue feature, p. 2007
Published: 2023

17. Supplementary Data from SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk

Author: Nicolas Reynoird, Nima Mosammaparast, Pawel K. Mazur, Pierre Hainaut, Michiel Vermeulen, Yohann Couté, Pascal W.T.C. Jansen, Marianne Tardif, Rebecca Rodell, Jessica Vayr, Ana Morales Benitez, Florent Chuffart, Alexandre G. Casanova, Joshua R. Brickner, Ning Tsao, Tanveer Ahmad, Clement Oyeniran, Gael S. Roth, Simone Hausmann, and Valentina Lukinović
Abstract: Supplementary Data from SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk
Published: 2023

18. Figure S2 from Efficacy of AKT Inhibitor ARQ 092 Compared with Sorafenib in a Cirrhotic Rat Model with Hepatocellular Carcinoma

Author: Thomas Decaens, Vincent Leroy, Patrice N. Marche, Benoit Busser, Yi Yu, Giovanni Abbadessa, Séyédéh Tayébéh Ahmad Pour, Keerthi Kurma, Ayca Zeybek Kuyucu, Zuzana Macek Jilkova, and Gaël S. Roth
Abstract: Migration
Published: 2023

19. Supplementary Table S6 from PRC2 Inhibitors Overcome Glucocorticoid Resistance Driven by NSD2 Mutation in Pediatric Acute Lymphoblastic Leukemia

Author: Jonathan D. Licht, Richard B. Lock, Matthew D. Hall, Adolfo A. Ferrando, Richard L. Bennett, Alberto Riva, Min Shen, Christine M. Will, Jon A. Oyer, Marta Kulis, Alok Swaroop, Catalina Troche, Heidi L. Casellas Román, Duohui Jing, Jacob S. Roth, Daphne Dupéré-Richér, Crissandra Piper, Jonathan H. Shrimp, Julia Hlavka-Zhang, and Jianping Li
Abstract: Differentially expressed genes in NSD2 p.E1099K RCH-ACV cells with the change of H3K27me3 peaks
Published: 2023

20. Supplementary Material and Method, Supplementary Tables 1-2, and Figure Legends from Efficacy of AKT Inhibitor ARQ 092 Compared with Sorafenib in a Cirrhotic Rat Model with Hepatocellular Carcinoma

Author: Thomas Decaens, Vincent Leroy, Patrice N. Marche, Benoit Busser, Yi Yu, Giovanni Abbadessa, Séyédéh Tayébéh Ahmad Pour, Keerthi Kurma, Ayca Zeybek Kuyucu, Zuzana Macek Jilkova, and Gaël S. Roth
Abstract: Supplementary Table 1: IC20 and IC50 values of ARQ 092 and sorafenib in Hep3B, Huh-7, HepG2, PLC/PRF/5 and HR4 cell lines after 48h of exposure; Supplementary Table 2: List of significantly different phospho-kinases from ARQ 092 treated rats compared to control group.
Published: 2023

21. Supplementary Methods and Figures from PRC2 Inhibitors Overcome Glucocorticoid Resistance Driven by NSD2 Mutation in Pediatric Acute Lymphoblastic Leukemia

Author: Jonathan D. Licht, Richard B. Lock, Matthew D. Hall, Adolfo A. Ferrando, Richard L. Bennett, Alberto Riva, Min Shen, Christine M. Will, Jon A. Oyer, Marta Kulis, Alok Swaroop, Catalina Troche, Heidi L. Casellas Román, Duohui Jing, Jacob S. Roth, Daphne Dupéré-Richér, Crissandra Piper, Jonathan H. Shrimp, Julia Hlavka-Zhang, and Jianping Li
Abstract: Supplementary Methods and Figures
Published: 2023

22. Data from PRC2 Inhibitors Overcome Glucocorticoid Resistance Driven by NSD2 Mutation in Pediatric Acute Lymphoblastic Leukemia

Author: Jonathan D. Licht, Richard B. Lock, Matthew D. Hall, Adolfo A. Ferrando, Richard L. Bennett, Alberto Riva, Min Shen, Christine M. Will, Jon A. Oyer, Marta Kulis, Alok Swaroop, Catalina Troche, Heidi L. Casellas Román, Duohui Jing, Jacob S. Roth, Daphne Dupéré-Richér, Crissandra Piper, Jonathan H. Shrimp, Julia Hlavka-Zhang, and Jianping Li
Abstract: Mutations in epigenetic regulators are common in relapsed pediatric acute lymphoblastic leukemia (ALL). Here, we uncovered the mechanism underlying the relapse of ALL driven by an activating mutation of the NSD2 histone methyltransferase (p.E1099K). Using high-throughput drug screening, we found that NSD2-mutant cells were specifically resistant to glucocorticoids. Correction of this mutation restored glucocorticoid sensitivity. The transcriptional response to glucocorticoids was blocked in NSD2-mutant cells due to depressed glucocorticoid receptor (GR) levels and the failure of glucocorticoids to autoactivate GR expression. Although H3K27me3 was globally decreased by NSD2 p.E1099K, H3K27me3 accumulated at the NR3C1 (GR) promoter. Pretreatment of NSD2 p.E1099K cell lines and patient-derived xenograft samples with PRC2 inhibitors reversed glucocorticoid resistance in vitro and in vivo. PRC2 inhibitors restored NR3C1 autoactivation by glucocorticoids, increasing GR levels and allowing GR binding and activation of proapoptotic genes. These findings suggest a new therapeutic approach to relapsed ALL associated with NSD2 mutation.Significance:NSD2 histone methyltransferase mutations observed in relapsed pediatric ALL drove glucocorticoid resistance by repression of the GR and abrogation of GR gene autoactivation due to accumulation of K3K27me3 at its promoter. Pretreatment with PRC2 inhibitors reversed resistance, suggesting a new therapeutic approach to these patients with ALL.This article is highlighted in the In This Issue feature, p. 1
Published: 2023

23. Supplementary Information and Data from The Combination of Vemurafenib and Procaspase-3 Activation Is Synergistic in Mutant BRAF Melanomas

Author: Paul J. Hergenrother, Howard S. Roth, Kathryn L. Wycislo, Timothy M. Fan, and Jessie Peh
Abstract: The supplementary information file contains details about primers used for this work, supplementary Figures S1-S8, supplementary Table S1, and results from cell line authentication and from mycoplasma testing.
Published: 2023

24. Supplementary Figure S3 from The Combination of Trametinib and Ganitumab is Effective in RAS-Mutated PAX-Fusion Negative Rhabdomyosarcoma Models

Author: Marielle E. Yohe, Javed Khan, Angelina V. Vaseva, Robert W. Robey, Robert L. Kortum, Frederic G. Barr, Simone Difilippantonio, Matthew D. Hall, Lu Chen, W. Douglas Figg, Jack F. Shern, Cody J. Peer, Noemi Kedei, Jin-Qiu Chen, Elijah F. Edmondson, Roberta Smith, Donna Butcher, Haiyan Lei, Xiaoling Luo, Priya Shankarappa, Parirokh Awasthi, Amy James, Christina M. Robinson, Kristine A. Isanogle, Wenyue Sun, Olivia L. Perkins, Stacey Stauffer, Angela Kim, William J.E. Frye, Nancy E. Sealover, David J. Liewehr, Jacob S. Roth, Xiaolin Wan, and Katie E. Hebron
Abstract: Pharmacodynamic response to trametinib/ganitumab in xenograft models does not predict tumor shrinkage
Published: 2023

25. Supplementary Data File S9 from The Combination of Trametinib and Ganitumab is Effective in RAS-Mutated PAX-Fusion Negative Rhabdomyosarcoma Models

Author: Marielle E. Yohe, Javed Khan, Angelina V. Vaseva, Robert W. Robey, Robert L. Kortum, Frederic G. Barr, Simone Difilippantonio, Matthew D. Hall, Lu Chen, W. Douglas Figg, Jack F. Shern, Cody J. Peer, Noemi Kedei, Jin-Qiu Chen, Elijah F. Edmondson, Roberta Smith, Donna Butcher, Haiyan Lei, Xiaoling Luo, Priya Shankarappa, Parirokh Awasthi, Amy James, Christina M. Robinson, Kristine A. Isanogle, Wenyue Sun, Olivia L. Perkins, Stacey Stauffer, Angela Kim, William J.E. Frye, Nancy E. Sealover, David J. Liewehr, Jacob S. Roth, Xiaolin Wan, and Katie E. Hebron
Abstract: Related to Figure 4
Published: 2023

26. Data from The Combination of Trametinib and Ganitumab is Effective in RAS-Mutated PAX-Fusion Negative Rhabdomyosarcoma Models

Author: Marielle E. Yohe, Javed Khan, Angelina V. Vaseva, Robert W. Robey, Robert L. Kortum, Frederic G. Barr, Simone Difilippantonio, Matthew D. Hall, Lu Chen, W. Douglas Figg, Jack F. Shern, Cody J. Peer, Noemi Kedei, Jin-Qiu Chen, Elijah F. Edmondson, Roberta Smith, Donna Butcher, Haiyan Lei, Xiaoling Luo, Priya Shankarappa, Parirokh Awasthi, Amy James, Christina M. Robinson, Kristine A. Isanogle, Wenyue Sun, Olivia L. Perkins, Stacey Stauffer, Angela Kim, William J.E. Frye, Nancy E. Sealover, David J. Liewehr, Jacob S. Roth, Xiaolin Wan, and Katie E. Hebron
Abstract: Purpose:PAX-fusion negative rhabdomyosarcoma (FN RMS) is driven by alterations in the RAS/MAP kinase pathway and is partially responsive to MEK inhibition. Overexpression of IGF1R and its ligands is also observed in FN RMS. Preclinical and clinical studies have suggested that IGF1R is itself an important target in FN RMS. Our previous studies revealed preclinical efficacy of the MEK1/2 inhibitor, trametinib, and an IGF1R inhibitor, BMS-754807, but this combination was not pursued clinically due to intolerability in preclinical murine models. Here, we sought to identify a combination of an MEK1/2 inhibitor and IGF1R inhibitor, which would be tolerated in murine models and effective in both cell line and patient-derived xenograft models of RAS-mutant FN RMS.Experimental Design:Using proliferation and apoptosis assays, we studied the factorial effects of trametinib and ganitumab (AMG 479), a mAb with specificity for human and murine IGF1R, in a panel of RAS-mutant FN RMS cell lines. The molecular mechanism of the observed synergy was determined using conventional and capillary immunoassays. The efficacy and tolerability of trametinib/ganitumab was assessed using a panel of RAS-mutated cell-line and patient-derived RMS xenograft models.Results:Treatment with trametinib and ganitumab resulted in synergistic cellular growth inhibition in all cell lines tested and inhibition of tumor growth in four of six models of RAS-mutant RMS. The combination had little effect on body weight and did not produce thrombocytopenia, neutropenia, or hyperinsulinemia in tumor-bearing SCID beige mice. Mechanistically, ganitumab treatment prevented the phosphorylation of AKT induced by MEK inhibition alone. Therapeutic response to the combination was observed in models without a mutation in the PI3K/PTEN axis.Conclusions:We demonstrate that combined trametinib and ganitumab is effective in a genomically diverse panel of RAS-mutated FN RMS preclinical models. Our data also show that the trametinib/ganitumab combination likely has a favorable tolerability profile. These data support testing this combination in a phase I/II clinical trial for pediatric patients with relapsed or refractory RAS-mutated FN RMS.
Published: 2023

27. Who gets caught by the emotion? Attentional biases toward emotional facial expressions and their link to social anxiety and autistic traits

Author: Julia Folz, Tom S. Roth, Milica Nikolić, and Mariska E. Kret
Subjects: General Psychology
Abstract: The emotional facial expressions of other individuals are a valuable information source in adapting behaviour to situational demands, and have been found to receive prioritized attention. Yet, enhanced attentional biases, such as a bias to social threat in Social Anxiety Disorder (SAD), or blunted attention to emotional information, as assumed in Autism Spectrum Disorder (ASD), can easily become maladaptive in daily life. In order to investigate individual differences in attentional biases toward different emotional expressions (angry, happy, sad, and fearful versus neutral) and their links to social anxiety and autistic traits, we tested 104 healthy participants with an emotional dot-probe paradigm on a touch screen, and measured clinical trait levels associated with ASD and SAD. While confirming the presence of attentional biases toward all emotional expressions, we did not find robust evidence for systematic links between these biases and either clinical trait dimension. Only an exploratory Bayesian analysis pointed to a less pronounced bias towards happy facial expressions with higher autistic trait levels. Moreover, a closer examination of the attentional bias towards angry facial expressions suggested that alterations in this bias might depend on a complex interplay between both trait dimensions. Novel approaches in the assessment of attentional biases might yield the potential to describe disorder-specific biases in attention to emotions more validly.
Published: 2023

28. Präklinisches Targeting des Angiotensin-II-Rezeptors 1 für MEN1-assoziierte neuroendokrine Neoplasien der Bauchspeicheldrüse

Author: D. Librizzi, J. Manoharan, J. Jedelska, S. Roth, K. Roth, P. Bertolino, C. X. Zhang, Y. Tu, G. B. Kotipalli, D. K. Bartsch, M. Luster, P. Di Fazio, and B. H. Yousefi
Published: 2023

29. Safety Evaluation of Automotive Electronics Using Virtual Prototypes: State of the Art and Research Challenges.

Author: Jan-Hendrik Oetjens, Nico Bannow, Markus Becker 0001, Oliver Bringmann 0001, Andreas Burger, Moomen Chaari, Samarjit Chakraborty, Rolf Drechsler, Wolfgang Ecker, Kim Grüttner, Thomas Kruse, Christoph Kuznik, Hoang Minh Le 0001, Andreas Mauderer, Wolfgang Müller 0003, Daniel Müller-Gritschneder, Frank Poppen, Hendrik Post, Sebastian Reiter 0003, Wolfgang Rosenstiel, S. Roth, Ulf Schlichtmann, Andreas von Schwerin, Bogdan-Andrei Tabacaru, and Alexander Viehl
Published: 2014
Full Text: View/download PDF

30. Exploring the Neandertal legacy of pancreatic ductal adenocarcinoma risk in Eurasians

Author: Manuel Gentiluomo, M. Piccardi, S. Bertoncini, E. Costello, L. Morelli, S. Landi, A. Milanetto, B. Schöttker, G. Di Franco, S. Ermini, A. Scarpa, J. Izbicki, R. Pezzilli, F. Uzunoglu, R. Talar-Wojnarowska, M. Goetz, R. Lawlor, M. Aoki, B. Bueno-de-Mesquita, O. Busch, R. Chammas, F. Tavano, H. van Laarhoven, G. Cavestro, H. Stocker, F. Bazzocchi, C. Pasquali, X. Chen, M. Puzzono, R. Ponz de Leon Pisani, C. Sperti, M. Lovecek, B. Erőss, D. Basso, J. Kupcinskas, T. Vanagas, D. Janciauskas, L. Poskiene, M. Tacelli, B. Mohelnikova Duchonova, F. Perri, A. Latiano, A. Mambrini, E. Maiello, P. Hegyi, A. Szentesi, S. Bunduc, T. Hussein, P. Arcidiacono, U. Boggi, T. Hackert, P. Soucek, M. Lucchesi, L. Ginocchi, M. Gazouli, A. Zerbi, S. Roth, K. Jamroziak, S. Carrara, V. Hlavac, M. Oliverius, J. Neoptolemos, G. Theodoropoulos, C. van Eijck, M. Dannemann, F. Canzian, S. Tofanelli, and D. Campa
Subjects: Hepatology, Endocrinology, Diabetes and Metabolism, Gastroenterology
Published: 2022

31. Observation of the $${{{\Lambda }} _{\text {b}}^{{0}}} \rightarrow {{\text {J}/\uppsi }} {{{\Xi }} ^{{-}}} {{\text {K}} ^{{+}}} $$ Λ b 0 → J / ψ Ξ - K + decay

Author: CMS Collaboration, A. Hayrapetyan, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, P. S. Hussain, M. Jeitler, N. Krammer, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M. R. Darwish, T. Janssen, P. Van Mechelen, E. S. Bols, J. D’Hondt, S. Dansana, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, I. Makarenko, D. Müller, A. R. Sahasransu, S. Tavernier, M. Tytgat, S. Van Putte, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, A. Khalilzadeh, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, Y. Hong, J. Knolle, L. Lambrecht, G. Mestdach, C. Rendón, A. Samalan, K. Skovpen, N. Van Den Bossche, L. Wezenbeek, A. Benecke, G. Bruno, C. Caputo, C. Delaere, I. S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, J. Lidrych, P. Mastrapasqua, K. Mondal, T. T. Tran, S. Wertz, G. A. Alves, E. Coelho, C. Hensel, T. Menezes De Oliveira, A. Moraes, P. Rebello Teles, M. Soeiro, W. L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, J. Martins, C. Mora Herrera, K. Mota Amarilo, L. Mundim, H. Nogima, A. Santoro, A. Sznajder, M. Thiel, A. Vilela Pereira, C. A. Bernardes, L. Calligaris, T. R. Fernandez Perez Tomei, E. M. Gregores, P. G. Mercadante, S. F. Novaes, B. Orzari, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Shopova, G. Sultanov, A. Dimitrov, T. Ivanov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, S. Thakur, T. Cheng, Q. Guo, T. Javaid, M. Mittal, L. Yuan, G. Bauer, Z. Hu, J. Liu, K. Yi, G. M. Chen, H. S. Chen, M. Chen, F. Iemmi, C. H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, F. Monti, M. A. Shahzad, R. Sharma, J. N. Song, J. Tao, C. Wang, J. Wang, Z. Wang, H. Zhang, A. Agapitos, Y. Ban, A. Levin, C. Li, Q. Li, Y. Mao, S. J. Qian, X. Sun, D. Wang, H. Yang, L. Zhang, C. Zhou, Z. You, N. Lu, X. Gao, D. Leggat, H. Okawa, Y. Zhang, Z. Lin, C. Lu, M. Xiao, C. Avila, D. A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J. A. Reyes Vega, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J. D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, A. Sculac, M. Kovac, T. Sculac, P. Bargassa, V. Brigljevic, B. K. Chitroda, D. Ferencek, S. Mishra, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, A. Kveton, E. Ayala, E. Carrera Jarrin, H. Abdalla, Y. Assran, M. Abdullah Al-Mashad, M. A. Mahmoud, R. K. Dewanjee, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, H. Kirschenmann, K. Osterberg, M. Voutilainen, S. 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Miguel Colin, B. P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, A. Bodek, P. de Barbaro, R. Demina, J. L. Dulemba, C. Fallon, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, P. Parygin, E. Popova, R. Taus, G. P. Van Onsem, K. Goulianos, B. Chiarito, J. P. Chou, Y. Gershtein, E. Halkiadakis, A. Hart, M. Heindl, D. Jaroslawski, O. Karacheban, I. Laflotte, A. Lath, R. Montalvo, K. Nash, H. Routray, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S. A. Thayil, S. Thomas, J. Vora, H. Wang, H. Acharya, D. Ally, A. G. Delannoy, S. Fiorendi, T. Holmes, N. Karunarathna, L. Lee, E. Nibigira, S. Spanier, D. Aebi, M. Ahmad, O. Bouhali, M. Dalchenko, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, S. Malhotra, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, V. Hegde, A. Hussain, Y. Kazhykarim, K. Lamichhane, A. Mankel, T. Mengke, S. Muthumuni, T. Peltola, I. Volobouev, A. Whitbeck, E. Appelt, S. Greene, A. Gurrola, W. Johns, R. Kunnawalkam Elayavalli, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, J. Hakala, R. Hirosky, A. Ledovskoy, A. Li, C. Neu, C. E. Perez Lara, P. E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C. K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W. H. Smith, D. Teague, H. F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, V. Chekhovsky, R. Chistov, M. Danilov, A. Dermenev, T. Dimova, D. Druzhkin, M. Dubinin, L. Dudko, A. Ershov, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, L. Kardapoltsev, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, O. Kodolova, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, V. Palichik, V. Perelygin, S. Petrushanko, S. Polikarpov, V. Popov, O. Radchenko, M. Savina, V. Savrin, M. Sergeev, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, A. Snigirev, D. Sosnov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, A. Vorobyev, N. Voytishin, B. S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract Using proton–proton collision data corresponding to an integrated luminosity of $$140\hbox { fb}^{-1}$$ 140 fb - 1 collected by the CMS experiment at $$\sqrt{s}= 13\,\text {Te}\hspace{-.08em}\text {V} $$ s = 13 Te V , the $${{{\Lambda }} _{\text {b}}^{{0}}} \rightarrow {{\text {J}/\uppsi }} {{{\Xi }} ^{{-}}} {{\text {K}} ^{{+}}} $$ Λ b 0 → J / ψ Ξ - K + decay is observed for the first time, with a statistical significance exceeding 5 standard deviations. The relative branching fraction, with respect to the $${{{\Lambda }} _{\text {b}}^{{0}}} \rightarrow {{{\uppsi }} ({2\textrm{S}})} {{\Lambda }} $$ Λ b 0 → ψ ( 2 S ) Λ decay, is measured to be $$\mathcal {B}({{{\Lambda }} _{\text {b}}^{{0}}} \rightarrow {{\text {J}/\uppsi }} {{{\Xi }} ^{{-}}} {{\text {K}} ^{{+}}} )/\mathcal {B}({{{\Lambda }} _{\text {b}}^{{0}}} \rightarrow {{{\uppsi }} ({2\textrm{S}})} {{\Lambda }} ) = [3.38\pm 1.02\pm 0.61\pm 0.03]\%$$ B ( Λ b 0 → J / ψ Ξ - K + ) / B ( Λ b 0 → ψ ( 2 S ) Λ ) = [ 3.38 ± 1.02 ± 0.61 ± 0.03 ] % , where the first uncertainty is statistical, the second is systematic, and the third is related to the uncertainties in $$\mathcal {B}({{{\uppsi }} ({2\textrm{S}})} \rightarrow {{\text {J}/\uppsi }} {{{\uppi }} ^{{+}}} {{{\uppi }} ^{{-}}} )$$ B ( ψ ( 2 S ) → J / ψ π + π - ) and $$\mathcal {B}({{{\Xi }} ^{{-}}} \rightarrow {{\Lambda }} {{{\uppi }} ^{{-}}} )$$ B ( Ξ - → Λ π - ) .
Published: 2024
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32. Search for Higgs boson pair production with one associated vector boson in proton-proton collisions at s $$ \sqrt{s} $$ = 13 TeV

Author: The CMS collaboration, A. Hayrapetyan, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, P. S. Hussain, M. Jeitler, N. Krammer, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M. R. Darwish, T. Janssen, P. Van Mechelen, E. S. Bols, J. D’Hondt, S. Dansana, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, I. Makarenko, D. Müller, A. R. Sahasransu, S. Tavernier, M. Tytgat, S. Van Putte, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, A. Khalilzadeh, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, Y. Hong, J. Knolle, L. Lambrecht, G. Mestdach, C. Rendón, A. Samalan, K. Skovpen, N. Van Den Bossche, L. Wezenbeek, A. Benecke, G. Bruno, C. Caputo, C. Delaere, I. S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, J. Lidrych, P. Mastrapasqua, K. Mondal, T. T. Tran, S. Wertz, G. A. Alves, E. Coelho, C. Hensel, T. Menezes De Oliveira, A. Moraes, P. Rebello Teles, M. Soeiro, W. L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, J. Martins, C. Mora Herrera, K. Mota Amarilo, L. Mundim, H. Nogima, A. Santoro, S. M. Silva Do Amaral, A. Sznajder, M. Thiel, A. Vilela Pereira, C. A. Bernardes, L. Calligaris, T. R. Fernandez Perez Tomei, E. M. Gregores, P. G. Mercadante, S. F. Novaes, B. Orzari, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Shopova, G. Sultanov, A. Dimitrov, T. Ivanov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, S. Thakur, T. Cheng, Q. Guo, T. Javaid, M. Mittal, L. Yuan, G. Bauer, Z. Hu, K. Yi, G. M. Chen, H. S. Chen, M. Chen, F. Iemmi, C. H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, F. Monti, M. A. Shahzad, R. Sharma, J. N. Song, J. Tao, C. Wang, J. Wang, Z. Wang, H. Zhang, A. Agapitos, Y. Ban, A. Levin, C. Li, Q. Li, X. Lyu, Y. Mao, S. J. Qian, X. Sun, D. Wang, H. Yang, L. Zhang, C. Zhou, Z. You, N. Lu, X. Gao, D. Leggat, H. Okawa, Y. Zhang, Z. Lin, C. Lu, M. Xiao, C. Avila, D. A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J. A. Reyes Vega, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J. D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, A. Sculac, M. Kovac, T. Sculac, P. Bargassa, V. Brigljevic, B. K. Chitroda, D. Ferencek, S. Mishra, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, A. Kveton, E. Ayala, E. Carrera Jarrin, A. A. Abdelalim, E. Salama, A. Lotfy, M. A. Mahmoud, R. K. Dewanjee, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, H. Kirschenmann, K. Osterberg, M. Voutilainen, S. Bharthuar, E. Brücken, F. Garcia, J. Havukainen, K. T. S. Kallonen, M. S. Kim, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, M. Lotti, L. Martikainen, M. Myllymäki, M. m. Rantanen, H. Siikonen, E. Tuominen, J. Tuominiemi, P. Luukka, H. Petrow, T. Tuuva, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J. L. Faure, F. Ferri, S. Ganjour, P. Gras, G. Hamel de Monchenault, V. Lohezic, J. Malcles, J. Rander, A. Rosowsky, M. Ö. Sahin, A. Savoy-Navarro, P. Simkina, M. Titov, C. Baldenegro Barrera, F. Beaudette, A. Buchot Perraguin, P. Busson, A. Cappati, C. Charlot, F. Damas, O. Davignon, A. De Wit, G. Falmagne, B. A. Fontana Santos Alves, S. Ghosh, A. Gilbert, R. Granier de Cassagnac, A. Hakimi, B. Harikrishnan, L. Kalipoliti, G. Liu, J. Motta, M. Nguyen, C. Ochando, L. Portales, R. Salerno, U. Sarkar, J. B. Sauvan, Y. Sirois, A. Tarabini, E. Vernazza, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Apparu, D. Bloch, J.-M. Brom, E. C. Chabert, C. Collard, S. Falke, U. Goerlach, C. Grimault, R. Haeberle, A.-C. Le Bihan, M. A. Sessini, P. Van Hove, S. Beauceron, B. Blancon, G. Boudoul, N. Chanon, J. Choi, D. Contardo, P. Depasse, C. Dozen, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, C. Greenberg, G. Grenier, B. Ille, I. B. Laktineh, M. Lethuillier, L. Mirabito, S. Perries, M. Vander Donckt, P. Verdier, J. Xiao, G. Adamov, I. Lomidze, Z. Tsamalaidze, V. Botta, L. Feld, K. Klein, M. Lipinski, D. Meuser, A. Pauls, N. Röwert, M. Teroerde, S. Diekmann, A. Dodonova, N. Eich, D. Eliseev, F. Engelke, M. Erdmann, P. Fackeldey, B. Fischer, T. Hebbeker, K. Hoepfner, F. Ivone, A. Jung, M. y. Lee, L. Mastrolorenzo, M. Merschmeyer, A. Meyer, S. Mukherjee, D. Noll, A. Novak, F. Nowotny, A. Pozdnyakov, Y. Rath, W. Redjeb, F. Rehm, H. Reithler, V. Sarkisovi, A. Schmidt, S. C. Schuler, A. Sharma, A. Stein, F. Torres Da Silva De Araujo, L. Vigilante, S. Wiedenbeck, S. Zaleski, C. Dziwok, G. Flügge, W. Haj Ahmad, T. Kress, A. Nowack, O. Pooth, A. Stahl, T. Ziemons, A. Zotz, H. Aarup Petersen, M. Aldaya Martin, J. Alimena, S. Amoroso, Y. An, S. Baxter, M. Bayatmakou, H. Becerril Gonzalez, O. Behnke, A. Belvedere, S. Bhattacharya, F. Blekman, K. Borras, D. Brunner, A. Campbell, A. Cardini, C. Cheng, F. Colombina, S. Consuegra Rodríguez, G. Correia Silva, M. De Silva, G. Eckerlin, D. Eckstein, L. I. Estevez Banos, O. Filatov, E. Gallo, A. Geiser, A. Giraldi, G. Greau, V. Guglielmi, M. Guthoff, A. Hinzmann, A. Jafari, L. Jeppe, N. Z. Jomhari, B. Kaech, M. Kasemann, H. Kaveh, C. Kleinwort, R. Kogler, M. Komm, D. Krücker, W. Lange, D. Leyva Pernia, K. Lipka, W. Lohmann, R. Mankel, I.-A. Melzer-Pellmann, M. Mendizabal Morentin, J. Metwally, A. B. Meyer, G. Milella, A. Mussgiller, A. Nürnberg, Y. Otarid, D. Pérez Adán, E. Ranken, A. Raspereza, B. Ribeiro Lopes, J. Rübenach, A. Saggio, M. Scham, S. Schnake, P. Schütze, C. Schwanenberger, D. Selivanova, M. Shchedrolosiev, R. E. Sosa Ricardo, L. P. Sreelatha Pramod, D. Stafford, F. Vazzoler, A. Ventura Barroso, R. Walsh, Q. Wang, Y. Wen, K. Wichmann, L. Wiens, C. Wissing, S. Wuchterl, Y. Yang, A. Zimermmane Castro Santos, A. Albrecht, S. Albrecht, M. Antonello, S. Bein, L. Benato, M. Bonanomi, P. Connor, M. Eich, K. El Morabit, Y. Fischer, A. Fröhlich, C. Garbers, E. Garutti, A. Grohsjean, M. Hajheidari, J. Haller, H. R. Jabusch, G. Kasieczka, P. Keicher, R. Klanner, W. Korcari, T. Kramer, V. Kutzner, F. Labe, J. Lange, A. Lobanov, C. Matthies, A. Mehta, L. Moureaux, M. Mrowietz, A. Nigamova, Y. Nissan, A. Paasch, K. J. Pena Rodriguez, T. Quadfasel, B. Raciti, M. Rieger, D. Savoiu, J. Schindler, P. Schleper, M. Schröder, J. Schwandt, M. Sommerhalder, H. Stadie, G. Steinbrück, A. Tews, M. Wolf, S. Brommer, M. Burkart, E. Butz, T. Chwalek, A. Dierlamm, A. Droll, N. Faltermann, M. Giffels, A. Gottmann, F. Hartmann, R. Hofsaess, M. Horzela, U. Husemann, M. Klute, R. Koppenhöfer, M. Link, A. Lintuluoto, S. Maier, S. Mitra, M. Mormile, Th. Müller, M. Neukum, M. Oh, G. Quast, K. Rabbertz, B. Regnery, N. Shadskiy, I. Shvetsov, H. J. Simonis, N. Trevisani, R. Ulrich, J. van der Linden, R. F. Von Cube, M. Wassmer, S. Wieland, F. Wittig, R. Wolf, S. Wunsch, X. Zuo, G. Anagnostou, P. Assiouras, G. Daskalakis, A. Kyriakis, A. Papadopoulos, A. Stakia, P. Kontaxakis, G. Melachroinos, A. Panagiotou, I. Papavergou, I. Paraskevas, N. Saoulidou, K. Theofilatos, E. Tziaferi, K. Vellidis, I. Zisopoulos, G. Bakas, T. Chatzistavrou, G. Karapostoli, K. Kousouris, I. Papakrivopoulos, E. Siamarkou, G. Tsipolitis, A. Zacharopoulou, K. Adamidis, I. Bestintzanos, I. Evangelou, C. Foudas, P. Gianneios, C. Kamtsikis, P. Katsoulis, P. Kokkas, P. G. Kosmoglou Kioseoglou, N. Manthos, I. Papadopoulos, J. Strologas, M. Bartók, C. Hajdu, D. Horvath, F. Sikler, V. Veszpremi, M. Csanád, K. Farkas, M. M. A. Gadallah, Á. Kadlecsik, P. Major, K. Mandal, G. Pásztor, A. J. Rádl, G. I. Veres, P. Raics, B. Ujvari, G. Zilizi, G. Bencze, S. Czellar, J. Karancsi, J. Molnar, Z. Szillasi, T. Csorgo, F. Nemes, T. Novak, J. Babbar, S. Bansal, S. B. Beri, V. Bhatnagar, G. Chaudhary, S. Chauhan, N. Dhingra, R. Gupta, A. Kaur, H. Kaur, M. Kaur, S. Kumar, M. Meena, K. Sandeep, T. Sheokand, J. B. Singh, A. Singla, A. Ahmed, A. Bhardwaj, A. Chhetri, B. C. Choudhary, A. Kumar, M. Naimuddin, K. Ranjan, S. Saumya, S. Acharya, S. Baradia, S. Barman, D. Bhowmik, S. Dutta, B. Gomber, P. Palit, G. Saha, B. Sahu, S. Sarkar, M. M. Ameen, P. K. Behera, S. C. Behera, P. Jana, P. Kalbhor, J. R. Komaragiri, D. Kumar, L. Panwar, R. Pradhan, P. R. Pujahari, N. R. Saha, A. K. Sikdar, S. Verma, T. Aziz, I. Das, S. Dugad, M. Kumar, G. B. Mohanty, P. Suryadevara, A. Bala, S. Banerjee, R. M. Chatterjee, M. Guchait, S. Karmakar, G. Majumder, K. Mazumdar, A. Thachayath, S. Bahinipati, A. K. Das, C. Kar, D. Maity, P. Mal, T. Mishra, V. K. Muraleedharan Nair Bindhu, K. Naskar, A. Nayak, P. Sadangi, P. Saha, S. K. Swain, S. Varghese, D. Vats, A. Alpana, S. Dube, B. Kansal, A. Laha, A. Rastogi, S. Sharma, H. Bakhshiansohi, E. Khazaie, M. Zeinali, S. Chenarani, S. M. Etesami, M. Khakzad, M. Mohammadi Najafabadi, M. Grunewald, M. Abbrescia, R. Aly, A. Colaleo, D. Creanza, B. D’Anzi, N. De Filippis, M. De Palma, A. Di Florio, W. Elmetenawee, L. Fiore, G. Iaselli, G. Maggi, M. Maggi, I. Margjeka, V. Mastrapasqua, S. My, S. Nuzzo, A. Pellecchia, A. Pompili, G. Pugliese, R. Radogna, G. Ramirez-Sanchez, D. Ramos, A. Ranieri, L. Silvestris, F. M. Simone, Ü. Sözbilir, A. Stamerra, R. Venditti, P. Verwilligen, A. Zaza, G. Abbiendi, C. Battilana, D. Bonacorsi, L. Borgonovi, R. Campanini, P. Capiluppi, A. Castro, F. R. Cavallo, M. Cuffiani, G. M. Dallavalle, T. Diotalevi, F. Fabbri, A. Fanfani, D. Fasanella, P. Giacomelli, L. Giommi, L. Guiducci, S. Lo Meo, L. Lunerti, S. Marcellini, G. Masetti, F. L. Navarria, A. Perrotta, F. Primavera, A. M. Rossi, T. Rovelli, G. P. Siroli, S. Costa, A. Di Mattia, R. Potenza, A. Tricomi, C. Tuve, G. Barbagli, G. Bardelli, B. Camaiani, A. Cassese, R. Ceccarelli, V. Ciulli, C. Civinini, R. D’Alessandro, E. Focardi, T. Kello, G. Latino, P. Lenzi, M. Lizzo, M. Meschini, S. Paoletti, A. Papanastassiou, G. Sguazzoni, L. Viliani, L. Benussi, S. Bianco, S. Meola, D. Piccolo, P. Chatagnon, F. Ferro, E. Robutti, S. Tosi, A. Benaglia, G. Boldrini, F. Brivio, F. Cetorelli, F. De Guio, M. E. Dinardo, P. Dini, S. Gennai, A. Ghezzi, P. Govoni, L. Guzzi, M. T. Lucchini, M. Malberti, S. Malvezzi, A. Massironi, D. Menasce, L. Moroni, M. Paganoni, D. Pedrini, B. S. Pinolini, S. Ragazzi, N. Redaelli, T. Tabarelli de Fatis, D. Zuolo, S. Buontempo, A. Cagnotta, F. Carnevali, N. Cavallo, A. De Iorio, F. Fabozzi, A. O. M. Iorio, L. Lista, P. Paolucci, B. Rossi, C. Sciacca, R. Ardino, P. Azzi, N. Bacchetta, P. Bortignon, A. Bragagnolo, R. Carlin, P. Checchia, T. Dorigo, F. Gasparini, U. Gasparini, G. Grosso, L. Layer, E. Lusiani, M. Margoni, G. Maron, A. T. Meneguzzo, M. Migliorini, J. Pazzini, P. Ronchese, R. Rossin, F. Simonetto, G. Strong, M. Tosi, A. Triossi, S. Ventura, H. Yarar, M. Zanetti, P. Zotto, A. Zucchetta, G. Zumerle, S. Abu Zeid, C. Aimè, A. Braghieri, S. Calzaferri, D. Fiorina, P. Montagna, V. Re, C. Riccardi, P. Salvini, I. Vai, P. Vitulo, S. Ajmal, P. Asenov, G. M. Bilei, D. Ciangottini, L. Fanò, M. Magherini, G. Mantovani, V. Mariani, M. Menichelli, F. Moscatelli, A. Piccinelli, M. Presilla, A. Rossi, A. Santocchia, D. Spiga, T. Tedeschi, P. Azzurri, G. Bagliesi, R. Bhattacharya, L. Bianchini, T. Boccali, E. Bossini, D. Bruschini, R. Castaldi, M. A. Ciocci, M. Cipriani, V. D’Amante, R. Dell’Orso, S. Donato, A. Giassi, F. Ligabue, D. Matos Figueiredo, A. Messineo, M. Musich, F. Palla, S. Parolia, A. Rizzi, G. Rolandi, S. Roy Chowdhury, T. Sarkar, A. Scribano, P. Spagnolo, R. Tenchini, G. Tonelli, N. Turini, A. Venturi, P. G. Verdini, P. Barria, M. Campana, F. Cavallari, L. Cunqueiro Mendez, D. Del Re, E. Di Marco, M. Diemoz, F. Errico, E. Longo, P. Meridiani, J. Mijuskovic, G. Organtini, F. Pandolfi, R. Paramatti, C. Quaranta, S. Rahatlou, C. Rovelli, F. Santanastasio, L. Soffi, R. Tramontano, N. Amapane, R. Arcidiacono, S. Argiro, M. Arneodo, N. Bartosik, R. Bellan, A. Bellora, C. Biino, N. Cartiglia, M. Costa, R. Covarelli, N. Demaria, L. Finco, M. Grippo, B. Kiani, F. Legger, F. Luongo, C. Mariotti, S. Maselli, A. Mecca, E. Migliore, M. Monteno, R. Mulargia, M. M. Obertino, G. Ortona, L. Pacher, N. Pastrone, M. Pelliccioni, M. Ruspa, F. Siviero, V. Sola, A. Solano, D. Soldi, A. Staiano, C. Tarricone, M. Tornago, D. Trocino, G. Umoret, E. Vlasov, S. Belforte, V. Candelise, M. Casarsa, F. Cossutti, K. De Leo, G. Della Ricca, S. Dogra, J. Hong, C. Huh, B. Kim, D. H. Kim, J. Kim, H. Lee, S. W. Lee, C. S. Moon, Y. D. Oh, M. S. Ryu, S. Sekmen, Y. C. Yang, G. Bak, P. Gwak, H. Kim, D. H. Moon, E. Asilar, D. Kim, T. J. Kim, J. A. Merlin, J. Park, S. Choi, S. Han, B. Hong, K. S. Lee, S. Lee, S. K. Park, J. Yoo, J. Goh, H. S. Kim, Y. Kim, J. Almond, J. H. Bhyun, W. Jun, J. S. Kim, S. Ko, H. Kwon, J. Lee, B. H. Oh, S. B. Oh, H. Seo, U. K. Yang, I. Yoon, W. Jang, D. Y. Kang, Y. Kang, S. Kim, B. Ko, J. S. H. Lee, Y. Lee, I. C. Park, Y. Roh, I. J. Watson, S. Yang, S. Ha, H. D. Yoo, M. Choi, M. R. Kim, I. Yu, T. Beyrouthy, Y. Maghrbi, K. Dreimanis, A. Gaile, G. Pikurs, A. Potrebko, M. Seidel, V. Veckalns, N. R. Strautnieks, M. Ambrozas, A. Juodagalvis, A. Rinkevicius, G. Tamulaitis, N. Bin Norjoharuddeen, I. Yusuff, Z. Zolkapli, J. F. Benitez, A. Castaneda Hernandez, H. A. Encinas Acosta, L. G. Gallegos Maríñez, M. León Coello, J. A. Murillo Quijada, A. Sehrawat, L. Valencia Palomo, G. Ayala, H. Castilla-Valdez, E. De La Cruz-Burelo, I. Heredia-De La Cruz, R. Lopez-Fernandez, C. A. Mondragon Herrera, A. Sánchez Hernández, C. Oropeza Barrera, M. Ramírez García, I. Bautista, I. Pedraza, H. A. Salazar Ibarguen, C. Uribe Estrada, I. Bubanja, N. Raicevic, P. H. Butler, A. Ahmad, M. I. Asghar, A. Awais, M. I. M. Awan, H. R. Hoorani, W. A. Khan, V. Avati, L. Grzanka, M. Malawski, H. Bialkowska, M. Bluj, B. Boimska, M. Górski, M. Kazana, M. Szleper, P. Zalewski, K. Bunkowski, K. Doroba, A. Kalinowski, M. Konecki, J. Krolikowski, A. Muhammad, K. Pozniak, W. Zabolotny, M. Araujo, D. Bastos, C. Beirão Da Cruz E Silva, A. Boletti, M. Bozzo, P. Faccioli, M. Gallinaro, J. Hollar, N. Leonardo, T. Niknejad, A. Petrilli, M. Pisano, J. Seixas, J. Varela, J. W. Wulff, P. Adzic, P. Milenovic, M. Dordevic, J. Milosevic, V. Rekovic, M. Aguilar-Benitez, J. Alcaraz Maestre, Cristina F. Bedoya, M. Cepeda, M. Cerrada, N. Colino, B. De La Cruz, A. Delgado Peris, D. Fernández Del Val, J. P. Fernández Ramos, J. Flix, M. C. Fouz, O. Gonzalez Lopez, S. Goy Lopez, J. M. Hernandez, M. I. Josa, J. León Holgado, D. Moran, C. M. Morcillo Perez, Á. Navarro Tobar, C. Perez Dengra, A. Pérez-Calero Yzquierdo, J. Puerta Pelayo, I. Redondo, D. D. Redondo Ferrero, L. Romero, S. Sánchez Navas, L. Urda Gómez, J. Vazquez Escobar, C. Willmott, J. F. de Trocóniz, B. 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Kachanov, L. Kardapoltsev, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, O. Kodolova, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, V. Palichik, V. Perelygin, M. Perfilov, S. Petrushanko, S. Polikarpov, V. Popov, O. Radchenko, M. Savina, V. Savrin, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, D. Sosnov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, A. Vorobyev, N. Voytishin, B. S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: Hadron-Hadron Scattering, Higgs Physics, Vector Boson Production, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract A search for Higgs boson pair (HH) production in association with a vector boson V (W or Z boson) is presented. The search is based on proton-proton collision data at a center-of-mass energy of 13 TeV, collected with the CMS detector at the LHC, corresponding to an integrated luminosity of 138 fb −1. Both hadronic and leptonic decays of V bosons are used. The leptons considered are electrons, muons, and neutrinos. The HH production is searched for in the b b ¯ b b ¯ $$ \textrm{b}\overline{\textrm{b}}\textrm{b}\overline{\textrm{b}} $$ decay channel. An observed (expected) upper limit at 95% confidence level of VHH production cross section is set at 294 (124) times the standard model prediction. Constraints are also set on the modifiers of the Higgs boson trilinear self-coupling, k λ , assuming k 2V = 1, and vice versa on the coupling of two Higgs bosons with two vector bosons, k 2V. The observed (expected) 95% confidence intervals of these coupling modifiers are −37.7 < k λ < 37.2 (−30.1 < k λ < 28.9) and −12.2 < k 2V < 13.5 (−7.2 < k 2V < 8.9), respectively.
Published: 2024
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33. Search for a resonance decaying to a W boson and a photon in proton-proton collisions at s $$ \sqrt{s} $$ = 13 TeV using leptonic W boson decays

Author: The CMS collaboration, A. Hayrapetyan, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, P. S. Hussain, M. Jeitler, N. Krammer, A. Li, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, T. Janssen, T. Van Laer, P. Van Mechelen, N. Breugelmans, J. D’Hondt, S. Dansana, A. De Moor, M. Delcourt, F. Heyen, S. Lowette, I. Makarenko, D. Müller, S. Tavernier, M. Tytgat, G. P. Van Onsem, S. Van Putte, D. Vannerom, B. Bilin, B. Clerbaux, A. K. Das, G. De Lentdecker, H. Evard, L. Favart, P. Gianneios, J. Jaramillo, A. Khalilzadeh, F. A. Khan, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, M. A. Shahzad, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, G. Gokbulut, Y. Hong, J. Knolle, L. Lambrecht, D. Marckx, K. Mota Amarilo, A. Samalan, K. Skovpen, N. Van Den Bossche, J. van der Linden, L. Wezenbeek, A. Benecke, A. Bethani, G. Bruno, C. Caputo, J. De Favereau De Jeneret, C. Delaere, I. S. Donertas, A. Giammanco, A. O. Guzel, Sa. Jain, V. Lemaitre, J. Lidrych, P. Mastrapasqua, T. T. Tran, S. Wertz, G. A. Alves, M. Alves Gallo Pereira, E. Coelho, G. Correia Silva, C. Hensel, T. Menezes De Oliveira, C. Mora Herrera, A. Moraes, P. Rebello Teles, M. Soeiro, A. Vilela Pereira, W. L. Aldá Júnior, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, R. Gomes De Souza, M. Macedo, J. Martins, L. Mundim, H. Nogima, J. P. Pinheiro, A. Santoro, A. Sznajder, M. Thiel, C. A. Bernardes, L. Calligaris, T. R. Fernandez Perez Tomei, E. M. Gregores, B. Lopes Da Costa, I. Maietto Silverio, P. G. Mercadante, S. F. Novaes, B. Orzari, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, D. Laroze, S. Thakur, T. Cheng, T. Javaid, L. Yuan, Z. Hu, Z. Liang, J. Liu, K. Yi, G. M. Chen, H. S. Chen, M. Chen, F. Iemmi, C. H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, R. Sharma, J. N. Song, J. Tao, C. Wang, J. Wang, Z. Wang, H. Zhang, J. Zhao, A. Agapitos, Y. Ban, S. Deng, B. Guo, C. Jiang, A. Levin, C. Li, Q. Li, Y. Mao, S. Qian, S. J. Qian, X. Qin, X. Sun, D. Wang, H. Yang, L. Zhang, Y. Zhao, C. Zhou, S. Yang, Z. You, K. Jaffel, N. Lu, G. Bauer, B. Li, J. Zhang, X. Gao, Y. Li, Z. Lin, C. Lu, M. Xiao, C. Avila, D. A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J. A. Reyes Vega, F. Ramirez, C. Rendón, M. Rodriguez, A. A. Ruales Barbosa, J. D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, A. Sculac, M. Kovac, A. Petkovic, T. Sculac, P. Bargassa, V. Brigljevic, B. K. Chitroda, D. Ferencek, K. Jakovcic, S. Mishra, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, A. Hadjiagapiou, C. Leonidou, J. Mousa, C. Nicolaou, L. Paizanos, F. Ptochos, P. A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, A. Kveton, E. Carrera Jarrin, Y. Assran, B. El-mahdy, S. Elgammal, M. A. Mahmoud, Y. Mohammed, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, H. Kirschenmann, K. Osterberg, M. Voutilainen, S. Bharthuar, N. Bin Norjoharuddeen, E. Brücken, F. Garcia, P. Inkaew, K. T. S. Kallonen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, L. Martikainen, M. Myllymäki, M. m. Rantanen, H. Siikonen, J. Tuominiemi, P. Luukka, H. Petrow, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J. L. Faure, F. Ferri, S. Ganjour, P. Gras, G. Hamel de Monchenault, M. Kumar, V. Lohezic, J. Malcles, F. Orlandi, L. Portales, A. Rosowsky, M. Ö. Sahin, A. Savoy-Navarro, P. Simkina, M. Titov, M. Tornago, F. Beaudette, G. Boldrini, P. Busson, A. Cappati, C. Charlot, M. Chiusi, F. Damas, O. Davignon, A. De Wit, I. T. Ehle, B. A. Fontana Santos Alves, S. Ghosh, A. Gilbert, R. Granier de Cassagnac, A. Hakimi, B. Harikrishnan, L. Kalipoliti, G. Liu, M. Nguyen, C. Ochando, R. Salerno, J. B. Sauvan, Y. Sirois, L. Urda Gómez, E. Vernazza, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Apparu, D. Bloch, J.-M. Brom, E. C. Chabert, C. Collard, S. Falke, U. Goerlach, R. Haeberle, A.-C. Le Bihan, M. Meena, O. Poncet, G. Saha, M. A. Sessini, P. Van Hove, P. Vaucelle, A. Di Florio, D. Amram, S. Beauceron, B. Blancon, G. Boudoul, N. Chanon, D. Contardo, P. Depasse, C. Dozen, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, C. Greenberg, G. Grenier, B. Ille, E. Jourd‘huy, I. B. Laktineh, M. Lethuillier, L. Mirabito, S. Perries, A. Purohit, M. Vander Donckt, P. Verdier, J. Xiao, I. Bagaturia, I. Lomidze, Z. Tsamalaidze, V. Botta, S. Consuegra Rodríguez, L. Feld, K. Klein, M. Lipinski, D. Meuser, A. Pauls, D. Pérez Adán, N. Röwert, M. Teroerde, S. Diekmann, A. Dodonova, N. Eich, D. Eliseev, F. Engelke, J. Erdmann, M. Erdmann, P. Fackeldey, B. Fischer, T. Hebbeker, K. Hoepfner, F. Ivone, A. Jung, M. y. Lee, F. Mausolf, M. Merschmeyer, A. Meyer, S. Mukherjee, D. Noll, F. Nowotny, A. Pozdnyakov, Y. Rath, W. Redjeb, F. Rehm, H. Reithler, V. Sarkisovi, A. Schmidt, C. Seth, A. Sharma, J. L. Spah, A. Stein, F. Torres Da Silva De Araujo, S. Wiedenbeck, S. Zaleski, C. Dziwok, G. Flügge, T. Kress, A. Nowack, O. Pooth, A. Stahl, T. Ziemons, A. Zotz, H. Aarup Petersen, M. Aldaya Martin, J. Alimena, S. Amoroso, Y. An, J. Bach, S. Baxter, M. Bayatmakou, H. Becerril Gonzalez, O. Behnke, A. Belvedere, F. Blekman, K. Borras, A. Campbell, A. Cardini, C. Cheng, F. Colombina, M. De Silva, G. Eckerlin, D. Eckstein, L. I. Estevez Banos, O. Filatov, E. Gallo, A. Geiser, V. Guglielmi, M. Guthoff, A. Hinzmann, L. Jeppe, B. Kaech, M. Kasemann, C. Kleinwort, R. Kogler, M. Komm, D. Krücker, W. Lange, D. Leyva Pernia, K. Lipka, W. Lohmann, F. Lorkowski, R. Mankel, I.-A. Melzer-Pellmann, M. Mendizabal Morentin, A. B. Meyer, G. Milella, K. Moral Figueroa, A. Mussgiller, L. P. Nair, J. Niedziela, A. Nürnberg, Y. Otarid, J. Park, E. Ranken, A. Raspereza, D. Rastorguev, J. Rübenach, L. Rygaard, A. Saggio, M. Scham, S. Schnake, P. Schütze, C. Schwanenberger, D. Selivanova, K. Sharko, M. Shchedrolosiev, D. Stafford, F. Vazzoler, A. Ventura Barroso, R. Walsh, Q. Wang, Y. Wen, K. Wichmann, L. Wiens, C. Wissing, Y. Yang, A. Zimermmane Castro Santos, A. Albrecht, S. Albrecht, M. Antonello, S. Bein, L. Benato, S. Bollweg, M. Bonanomi, P. Connor, K. El Morabit, Y. Fischer, E. Garutti, A. Grohsjean, J. Haller, H. R. Jabusch, G. Kasieczka, P. Keicher, R. Klanner, W. Korcari, T. Kramer, C. c. Kuo, V. Kutzner, F. Labe, J. Lange, A. Lobanov, C. Matthies, L. Moureaux, M. Mrowietz, A. Nigamova, Y. Nissan, A. Paasch, K. J. Pena Rodriguez, T. Quadfasel, B. Raciti, M. Rieger, D. Savoiu, J. Schindler, P. Schleper, M. Schröder, J. Schwandt, M. Sommerhalder, H. Stadie, G. Steinbrück, A. Tews, M. Wolf, S. Brommer, M. Burkart, E. Butz, T. Chwalek, A. Dierlamm, A. Droll, U. Elicabuk, N. Faltermann, M. Giffels, A. Gottmann, F. Hartmann, R. Hofsaess, M. Horzela, U. Husemann, J. Kieseler, M. Klute, R. Koppenhöfer, J. M. Lawhorn, M. Link, A. Lintuluoto, B. Maier, S. Maier, S. Mitra, M. Mormile, Th. Müller, M. Neukum, M. Oh, E. Pfeffer, M. Presilla, G. Quast, K. Rabbertz, B. Regnery, N. Shadskiy, I. Shvetsov, H. J. Simonis, L. Sowa, L. Stockmeier, K. Tauqeer, M. Toms, N. Trevisani, R. F. Von Cube, M. Wassmer, S. Wieland, F. Wittig, R. Wolf, X. Zuo, G. Anagnostou, G. Daskalakis, A. Kyriakis, A. Papadopoulos, A. Stakia, P. Kontaxakis, G. Melachroinos, Z. Painesis, I. Papavergou, I. Paraskevas, N. Saoulidou, K. Theofilatos, E. Tziaferi, K. Vellidis, I. Zisopoulos, G. Bakas, T. Chatzistavrou, G. Karapostoli, K. Kousouris, I. Papakrivopoulos, E. Siamarkou, G. Tsipolitis, A. Zacharopoulou, K. Adamidis, I. Bestintzanos, I. Evangelou, C. Foudas, C. Kamtsikis, P. Katsoulis, P. Kokkas, P. G. Kosmoglou Kioseoglou, N. Manthos, I. Papadopoulos, J. Strologas, C. Hajdu, D. Horvath, K. Márton, A. J. Rádl, F. Sikler, V. Veszpremi, M. Csanád, K. Farkas, A. Fehérkuti, M. M. A. Gadallah, Á. Kadlecsik, P. Major, G. Pásztor, G. I. Veres, B. Ujvari, G. Zilizi, G. Bencze, S. Czellar, J. Molnar, Z. Szillasi, F. Nemes, T. Novak, S. Bansal, S. B. Beri, V. Bhatnagar, G. Chaudhary, S. Chauhan, N. Dhingra, A. Kaur, H. Kaur, M. Kaur, S. Kumar, K. Sandeep, T. Sheokand, J. B. Singh, A. Singla, A. Ahmed, A. Bhardwaj, A. Chhetri, B. C. Choudhary, A. Kumar, M. Naimuddin, K. Ranjan, M. K. Saini, S. Saumya, S. Baradia, S. Barman, S. Bhattacharya, S. Das Gupta, S. Dutta, S. Sarkar, M. M. Ameen, P. K. Behera, S. C. Behera, G. Dash, P. Jana, P. Kalbhor, S. Kamble, J. R. Komaragiri, D. Kumar, P. R. Pujahari, N. R. Saha, A. K. Sikdar, R. K. Singh, P. Verma, S. Verma, A. Vijay, S. Dugad, G. B. Mohanty, B. Parida, M. Shelake, P. Suryadevara, A. Bala, S. Banerjee, R. M. Chatterjee, M. Guchait, Sh. Jain, A. Jaiswal, G. Majumder, K. Mazumdar, S. Parolia, A. Thachayath, S. Bahinipati, C. Kar, D. Maity, P. Mal, T. Mishra, V. K. Muraleedharan Nair Bindhu, K. Naskar, A. Nayak, S. Nayak, K. Pal, P. Sadangi, S. K. Swain, S. Varghese, D. Vats, S. Acharya, A. Alpana, S. Dube, B. Gomber, P. Hazarika, B. Kansal, A. Laha, B. Sahu, S. Sharma, K. Y. Vaish, H. Bakhshiansohi, A. Jafari, M. Zeinali, S. Bashiri, S. Chenarani, S. M. Etesami, Y. Hosseini, M. Khakzad, E. Khazaie, M. Mohammadi Najafabadi, S. Tizchang, M. Felcini, M. Grunewald, M. Abbrescia, A. Colaleo, D. Creanza, B. D’Anzi, N. De Filippis, M. De Palma, W. Elmetenawee, L. Fiore, G. Iaselli, L. Longo, M. Louka, G. Maggi, M. Maggi, I. Margjeka, V. Mastrapasqua, S. My, S. Nuzzo, A. Pellecchia, A. Pompili, G. Pugliese, R. Radogna, D. Ramos, A. Ranieri, L. Silvestris, F. M. Simone, Ü. Sözbilir, A. Stamerra, D. Troiano, R. Venditti, P. Verwilligen, A. Zaza, G. Abbiendi, C. Battilana, D. Bonacorsi, P. Capiluppi, A. Castro, F. R. Cavallo, M. Cuffiani, G. M. Dallavalle, T. Diotalevi, F. Fabbri, A. Fanfani, D. Fasanella, P. Giacomelli, L. Giommi, C. Grandi, L. Guiducci, S. Lo Meo, M. Lorusso, L. Lunerti, S. Marcellini, G. Masetti, F. L. Navarria, G. Paggi, A. Perrotta, F. Primavera, A. M. Rossi, S. Rossi Tisbeni, T. Rovelli, G. P. Siroli, S. Costa, A. Di Mattia, A. Lapertosa, R. Potenza, A. Tricomi, C. Tuve, P. Assiouras, G. Barbagli, G. Bardelli, B. Camaiani, A. Cassese, R. Ceccarelli, V. Ciulli, C. Civinini, R. D’Alessandro, E. Focardi, T. Kello, G. Latino, P. Lenzi, M. Lizzo, M. Meschini, S. Paoletti, A. Papanastassiou, G. Sguazzoni, L. Viliani, L. Benussi, S. Bianco, S. Meola, D. Piccolo, P. Chatagnon, F. Ferro, E. Robutti, S. Tosi, A. Benaglia, F. Brivio, F. Cetorelli, F. De Guio, M. E. Dinardo, P. Dini, S. Gennai, R. Gerosa, A. Ghezzi, P. Govoni, L. Guzzi, M. T. Lucchini, M. Malberti, S. Malvezzi, A. Massironi, D. Menasce, L. Moroni, M. Paganoni, S. Palluotto, D. Pedrini, A. Perego, B. S. Pinolini, G. Pizzati, S. Ragazzi, T. Tabarelli de Fatis, S. Buontempo, A. Cagnotta, F. Carnevali, N. Cavallo, F. Fabozzi, A. O. M. Iorio, L. 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Roy Chowdhury, T. Sarkar, A. Scribano, P. Spagnolo, R. Tenchini, G. Tonelli, N. Turini, F. Vaselli, A. Venturi, P. G. Verdini, C. Baldenegro Barrera, P. Barria, C. Basile, M. Campana, F. Cavallari, L. Cunqueiro Mendez, D. Del Re, E. Di Marco, M. Diemoz, F. Errico, E. Longo, J. Mijuskovic, G. Organtini, F. Pandolfi, R. Paramatti, C. Quaranta, S. Rahatlou, C. Rovelli, F. Santanastasio, L. Soffi, N. Amapane, R. Arcidiacono, S. Argiro, M. Arneodo, N. Bartosik, R. Bellan, A. Bellora, C. Biino, C. Borca, N. Cartiglia, M. Costa, R. Covarelli, N. Demaria, L. Finco, M. Grippo, B. Kiani, F. Legger, F. Luongo, C. Mariotti, L. Markovic, S. Maselli, A. Mecca, L. Menzio, P. Meridiani, E. Migliore, M. Monteno, R. Mulargia, M. M. Obertino, G. Ortona, L. Pacher, N. Pastrone, M. Pelliccioni, M. Ruspa, F. Siviero, V. Sola, A. Solano, A. Staiano, C. Tarricone, D. Trocino, G. Umoret, R. White, J. Babbar, S. Belforte, V. Candelise, M. Casarsa, F. Cossutti, K. De Leo, G. Della Ricca, S. Dogra, J. Hong, C. 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De La Cruz-Burelo, I. Heredia-De La Cruz, R. Lopez-Fernandez, J. Mejia Guisao, C. A. Mondragon Herrera, A. Sánchez Hernández, C. Oropeza Barrera, D. L. Ramirez Guadarrama, M. Ramírez García, I. Bautista, I. Pedraza, H. A. Salazar Ibarguen, C. Uribe Estrada, I. Bubanja, N. Raicevic, P. H. Butler, A. Ahmad, M. I. Asghar, A. Awais, M. I. M. Awan, H. R. Hoorani, W. A. Khan, V. Avati, L. Grzanka, M. Malawski, H. Bialkowska, M. Bluj, M. Górski, M. Kazana, M. Szleper, P. Zalewski, K. Bunkowski, K. Doroba, A. Kalinowski, M. Konecki, J. Krolikowski, A. Muhammad, K. Pozniak, W. Zabolotny, M. Araujo, D. Bastos, C. Beirão Da Cruz E Silva, A. Boletti, M. Bozzo, T. Camporesi, G. Da Molin, P. Faccioli, M. Gallinaro, J. Hollar, N. Leonardo, G. B. Marozzo, T. Niknejad, A. Petrilli, M. Pisano, J. Seixas, J. Varela, J. W. Wulff, P. Adzic, P. Milenovic, M. Dordevic, J. Milosevic, V. Rekovic, J. Alcaraz Maestre, Cristina F. Bedoya, Oliver M. Carretero, M. Cepeda, M. Cerrada, N. Colino, B. De La Cruz, A. Delgado Peris, A. Escalante Del Valle, D. Fernández Del Val, J. P. Fernández Ramos, J. Flix, M. C. Fouz, O. Gonzalez Lopez, S. Goy Lopez, J. M. Hernandez, M. I. Josa, E. Martin Viscasillas, D. Moran, C. M. Morcillo Perez, Á. Navarro Tobar, C. Perez Dengra, A. Pérez-Calero Yzquierdo, J. Puerta Pelayo, I. Redondo, S. Sánchez Navas, J. Sastre, J. Vazquez Escobar, J. F. de Trocóniz, B. Alvarez Gonzalez, J. Cuevas, J. Fernandez Menendez, S. Folgueras, I. Gonzalez Caballero, J. R. González Fernández, P. Leguina, E. Palencia Cortezon, J. Prado Pico, C. Ramón Álvarez, V. Rodríguez Bouza, A. Soto Rodríguez, A. Trapote, C. Vico Villalba, P. Vischia, S. Bhowmik, S. Blanco Fernández, J. A. Brochero Cifuentes, I. J. Cabrillo, A. Calderon, J. Duarte Campderros, M. Fernandez, G. Gomez, C. Lasaosa García, R. Lopez Ruiz, C. Martinez Rivero, P. Martinez Ruiz del Arbol, F. Matorras, P. Matorras Cuevas, E. Navarrete Ramos, J. Piedra Gomez, L. Scodellaro, I. Vila, J. M. Vizan Garcia, B. Kailasapathy, D. D. C. Wickramarathna, W. G. D. Dharmaratna, K. Liyanage, N. Perera, D. Abbaneo, C. Amendola, E. Auffray, G. Auzinger, J. Baechler, D. Barney, A. Bermúdez Martínez, M. Bianco, A. A. Bin Anuar, A. Bocci, L. Borgonovi, C. Botta, E. Brondolin, C. Caillol, G. Cerminara, N. Chernyavskaya, D. d’Enterria, A. Dabrowski, A. David, A. De Roeck, M. M. Defranchis, M. Deile, M. Dobson, G. Franzoni, W. Funk, S. Giani, D. Gigi, K. Gill, F. Glege, J. Hegeman, J. K. Heikkilä, B. Huber, V. Innocente, T. James, P. Janot, O. Kaluzinska, O. Karacheban, S. Laurila, P. Lecoq, E. Leutgeb, C. Lourenço, L. Malgeri, M. Mannelli, M. Matthewman, A. Mehta, F. Meijers, S. Mersi, E. Meschi, V. Milosevic, F. Monti, F. Moortgat, M. Mulders, I. Neutelings, S. Orfanelli, F. Pantaleo, G. Petrucciani, A. Pfeiffer, M. Pierini, H. Qu, D. Rabady, B. Ribeiro Lopes, M. Rovere, H. Sakulin, S. Sanchez Cruz, S. Scarfi, C. Schwick, M. Selvaggi, K. Shchelina, P. Silva, P. Sphicas, A. G. Stahl Leiton, A. Steen, S. Summers, D. Treille, P. Tropea, D. Walter, J. Wanczyk, K. A. Wozniak, S. Wuchterl, P. Zehetner, P. Zejdl, W. D. Zeuner, T. Bevilacqua, L. Caminada, A. Ebrahimi, W. Erdmann, R. Horisberger, Q. Ingram, H. C. Kaestli, D. Kotlinski, C. Lange, M. Missiroli, L. Noehte, T. Rohe, T. K. Aarrestad, K. Androsov, M. Backhaus, G. Bonomelli, A. Calandri, C. Cazzaniga, K. Datta, P. De Bryas Dexmiers D‘archiac, A. De Cosa, G. Dissertori, M. Dittmar, M. Donegà, F. Eble, M. Galli, K. Gedia, F. Glessgen, C. Grab, N. Härringer, T. G. Harte, D. Hits, W. Lustermann, A.-M. Lyon, R. A. Manzoni, M. Marchegiani, L. Marchese, C. Martin Perez, A. Mascellani, F. Nessi-Tedaldi, F. Pauss, V. Perovic, S. Pigazzini, C. Reissel, B. Ristic, F. Riti, R. Seidita, J. Steggemann, A. Tarabini, D. Valsecchi, R. Wallny, C. Amsler, P. Bärtschi, M. F. Canelli, K. Cormier, M. Huwiler, W. Jin, A. Jofrehei, B. Kilminster, S. Leontsinis, S. P. Liechti, A. Macchiolo, P. Meiring, F. Meng, U. Molinatti, J. Motta, A. Reimers, P. Robmann, M. Senger, E. Shokr, F. Stäger, R. Tramontano, C. Adloff, D. Bhowmik, C. M. Kuo, W. Lin, P. K. Rout, P. C. Tiwari, S. S. Yu, L. Ceard, K. F. Chen, P. s. Chen, Z. g. Chen, A. De Iorio, W.-S. Hou, T. h. Hsu, Y. w. Kao, S. Karmakar, G. Kole, Y. y. Li, R.-S. Lu, E. Paganis, X. f. Su, J. Thomas-Wilsker, L. s. Tsai, D. Tsionou, H. y. Wu, E. Yazgan, C. Asawatangtrakuldee, N. Srimanobhas, V. Wachirapusitanand, D. Agyel, F. Boran, F. Dolek, I. Dumanoglu, E. Eskut, Y. Guler, E. Gurpinar Guler, C. Isik, O. Kara, A. Kayis Topaksu, U. Kiminsu, G. Onengut, K. Ozdemir, A. Polatoz, B. Tali, U. G. Tok, S. Turkcapar, E. Uslan, I. S. Zorbakir, G. Sokmen, M. Yalvac, B. Akgun, I. O. Atakisi, E. Gülmez, M. Kaya, O. Kaya, S. Tekten, A. Cakir, K. Cankocak, G. G. Dincer, Y. Komurcu, S. Sen, O. Aydilek, B. Hacisahinoglu, I. Hos, B. Kaynak, S. Ozkorucuklu, O. Potok, H. Sert, C. Simsek, C. Zorbilmez, S. Cerci, B. Isildak, D. Sunar Cerci, T. Yetkin, A. Boyaryntsev, B. Grynyov, L. Levchuk, D. Anthony, J. J. Brooke, A. Bundock, F. Bury, E. Clement, D. Cussans, H. Flacher, M. Glowacki, J. Goldstein, H. F. Heath, M.-L. Holmberg, L. Kreczko, S. Paramesvaran, L. Robertshaw, S. Seif El Nasr-Storey, V. J. Smith, N. Stylianou, K. Walkingshaw Pass, A. H. Ball, K. W. Bell, A. Belyaev, C. Brew, R. M. Brown, D. J. A. Cockerill, C. Cooke, A. Elliot, K. V. Ellis, K. Harder, S. Harper, J. Linacre, K. Manolopoulos, D. M. Newbold, E. Olaiya, D. Petyt, T. Reis, A. R. Sahasransu, G. Salvi, T. Schuh, C. H. Shepherd-Themistocleous, I. R. Tomalin, K. C. Whalen, T. Williams, I. Andreou, R. Bainbridge, P. Bloch, C. E. Brown, O. Buchmuller, V. Cacchio, C. A. Carrillo Montoya, G. S. Chahal, D. Colling, J. S. Dancu, I. Das, P. Dauncey, G. Davies, J. Davies, M. Della Negra, S. Fayer, G. Fedi, G. Hall, M. H. Hassanshahi, A. Howard, G. Iles, C. R. Knight, J. Langford, J. León Holgado, L. Lyons, A.-M. Magnan, S. Mallios, M. Mieskolainen, J. Nash, M. Pesaresi, P. B. Pradeep, B. C. Radburn-Smith, A. Richards, A. Rose, K. Savva, C. Seez, R. Shukla, A. Tapper, K. Uchida, G. P. Uttley, L. H. Vage, T. Virdee, M. Vojinovic, N. Wardle, D. Winterbottom, K. Coldham, J. E. Cole, A. Khan, P. Kyberd, I. D. Reid, S. Abdullin, A. Brinkerhoff, E. Collins, M. R. Darwish, J. Dittmann, K. Hatakeyama, J. Hiltbrand, B. McMaster, J. Samudio, S. Sawant, C. Sutantawibul, J. Wilson, R. Bartek, A. Dominguez, C. Huerta Escamilla, A. E. Simsek, R. Uniyal, A. M. Vargas Hernandez, B. Bam, A. Buchot Perraguin, R. Chudasama, S. I. Cooper, C. Crovella, S. V. Gleyzer, E. Pearson, C. U. Perez, P. Rumerio, E. Usai, R. Yi, A. Akpinar, C. Cosby, G. De Castro, Z. Demiragli, C. Erice, C. Fangmeier, C. Fernandez Madrazo, E. Fontanesi, D. Gastler, F. Golf, S. Jeon, J. O‘cain, I. Reed, J. Rohlf, K. Salyer, D. Sperka, D. Spitzbart, I. Suarez, A. Tsatsos, A. G. Zecchinelli, G. Benelli, D. Cutts, L. Gouskos, M. Hadley, U. Heintz, J. M. Hogan, T. Kwon, G. Landsberg, K. T. Lau, D. Li, J. Luo, S. Mondal, N. Pervan, T. Russell, S. Sagir, X. Shen, F. Simpson, M. Stamenkovic, N. Venkatasubramanian, X. Yan, S. Abbott, C. Brainerd, R. Breedon, H. Cai, M. Calderon De La Barca Sanchez, M. Chertok, M. Citron, J. Conway, P. T. Cox, R. Erbacher, F. Jensen, O. Kukral, G. Mocellin, M. Mulhearn, S. Ostrom, W. Wei, S. Yoo, F. Zhang, M. Bachtis, R. Cousins, A. Datta, G. Flores Avila, J. Hauser, M. Ignatenko, M. A. Iqbal, T. Lam, E. Manca, A. Nunez Del Prado, D. Saltzberg, V. Valuev, R. Clare, J. W. Gary, M. Gordon, G. Hanson, W. Si, A. Aportela, A. Arora, J. G. Branson, S. Cittolin, S. Cooperstein, D. Diaz, J. Duarte, L. Giannini, Y. Gu, J. Guiang, R. Kansal, V. Krutelyov, R. Lee, J. Letts, M. Masciovecchio, F. Mokhtar, M. Pieri, M. Quinnan, B. V. Sathia Narayanan, V. Sharma, M. Tadel, E. Vourliotis, F. Würthwein, Y. Xiang, A. Yagil, A. Barzdukas, L. Brennan, C. Campagnari, K. Downham, C. Grieco, J. Incandela, A. J. Li, P. Masterson, H. Mei, J. Richman, S. N. Santpur, U. Sarica, R. Schmitz, F. Setti, J. Sheplock, D. Stuart, T. Á. Vámi, S. Wang, D. Zhang, A. Bornheim, O. Cerri, A. Latorre, J. Mao, H. B. Newman, G. Reales Gutiérrez, M. Spiropulu, J. R. Vlimant, S. Xie, R. Y. Zhu, J. Alison, S. An, P. Bryant, M. Cremonesi, V. Dutta, T. Ferguson, T. A. Gómez Espinosa, A. Harilal, A. Kallil Tharayil, C. Liu, T. Mudholkar, S. Murthy, P. Palit, K. Park, M. Paulini, A. Roberts, A. Sanchez, W. Terrill, J. P. Cumalat, W. T. Ford, A. Hart, A. Hassani, G. Karathanasis, N. Manganelli, J. Pearkes, C. Savard, N. Schonbeck, K. Stenson, K. A. Ulmer, S. R. Wagner, N. Zipper, D. Zuolo, J. Alexander, S. Bright-Thonney, X. Chen, D. J. Cranshaw, J. Fan, X. Fan, S. Hogan, P. Kotamnives, J. Monroy, M. Oshiro, J. R. Patterson, M. Reid, A. Ryd, J. Thom, P. Wittich, R. Zou, M. Albrow, M. Alyari, O. Amram, G. Apollinari, A. Apresyan, L. A. T. Bauerdick, D. Berry, J. Berryhill, P. C. Bhat, K. Burkett, J. N. Butler, A. Canepa, G. B. Cerati, H. W. K. Cheung, F. Chlebana, G. Cummings, J. Dickinson, I. Dutta, V. D. Elvira, Y. Feng, J. Freeman, A. Gandrakota, Z. Gecse, L. Gray, D. Green, A. Grummer, S. Grünendahl, D. Guerrero, O. Gutsche, R. M. Harris, R. Heller, T. C. Herwig, J. Hirschauer, B. Jayatilaka, S. Jindariani, M. Johnson, U. Joshi, T. Klijnsma, B. Klima, K. H. M. Kwok, S. Lammel, D. Lincoln, R. Lipton, T. Liu, C. Madrid, K. Maeshima, C. Mantilla, D. Mason, P. McBride, P. Merkel, S. Mrenna, S. Nahn, J. Ngadiuba, D. Noonan, S. Norberg, V. Papadimitriou, N. Pastika, K. Pedro, C. Pena, F. Ravera, A. Reinsvold Hall, L. Ristori, M. Safdari, E. Sexton-Kennedy, N. Smith, A. Soha, L. Spiegel, S. Stoynev, J. Strait, L. Taylor, S. Tkaczyk, N. V. Tran, L. Uplegger, E. W. Vaandering, I. Zoi, C. Aruta, P. Avery, D. Bourilkov, P. Chang, V. Cherepanov, R. D. Field, E. Koenig, M. Kolosova, J. Konigsberg, A. Korytov, K. Matchev, N. Menendez, G. Mitselmakher, K. Mohrman, A. Muthirakalayil Madhu, N. Rawal, S. Rosenzweig, Y. Takahashi, T. Adams, A. Al Kadhim, A. Askew, S. Bower, V. Hagopian, R. Hashmi, R. S. Kim, T. Kolberg, G. Martinez, H. Prosper, P. R. Prova, M. Wulansatiti, R. Yohay, B. Alsufyani, M. M. Baarmand, S. Butalla, S. Das, T. Elkafrawy, M. Hohlmann, E. Yanes, M. R. Adams, A. Baty, C. Bennett, R. Cavanaugh, R. Escobar Franco, O. Evdokimov, C. E. Gerber, M. Hawksworth, A. Hingrajiya, D. J. Hofman, J. h. Lee, D. S. Lemos, A. H. Merrit, C. Mills, S. Nanda, G. Oh, B. Ozek, D. Pilipovic, R. Pradhan, E. Prifti, T. Roy, S. Rudrabhatla, M. B. Tonjes, N. Varelas, M. A. Wadud, Z. Ye, M. Alhusseini, D. Blend, K. Dilsiz, L. Emediato, G. Karaman, O. K. Köseyan, J.-P. Merlo, A. Mestvirishvili, O. Neogi, H. Ogul, Y. Onel, A. Penzo, C. Snyder, E. Tiras, B. Blumenfeld, L. Corcodilos, J. Davis, A. V. Gritsan, L. Kang, S. Kyriacou, P. Maksimovic, M. Roguljic, J. Roskes, S. Sekhar, M. Swartz, A. Abreu, L. F. Alcerro Alcerro, J. Anguiano, S. Arteaga Escatel, P. Baringer, A. Bean, Z. Flowers, D. Grove, J. King, G. Krintiras, M. Lazarovits, C. Le Mahieu, J. Marquez, M. Murray, M. Nickel, M. Pitt, S. Popescu, C. Rogan, C. Royon, R. Salvatico, S. Sanders, C. Smith, G. Wilson, B. Allmond, R. Gujju Gurunadha, A. Ivanov, K. Kaadze, Y. Maravin, J. Natoli, D. Roy, G. Sorrentino, A. Baden, A. Belloni, J. Bistany-riebman, Y. M. Chen, S. C. Eno, N. J. Hadley, S. Jabeen, R. G. Kellogg, T. Koeth, B. Kronheim, Y. Lai, S. Lascio, A. C. Mignerey, S. Nabili, C. Palmer, C. Papageorgakis, M. M. Paranjpe, E. Popova, A. Shevelev, L. Wang, J. Bendavid, I. A. Cali, P. c. Chou, M. D’Alfonso, J. Eysermans, C. Freer, G. Gomez-Ceballos, M. Goncharov, G. Grosso, P. Harris, D. Hoang, D. Kovalskyi, J. Krupa, L. Lavezzo, Y.-J. Lee, K. Long, C. Mcginn, A. Novak, C. Paus, C. Roland, G. Roland, S. Rothman, G. S. F. Stephans, B. Wyslouch, T. J. Yang, B. Crossman, B. M. Joshi, C. Kapsiak, M. Krohn, D. Mahon, J. Mans, B. Marzocchi, M. Revering, R. Rusack, R. Saradhy, N. Strobbe, K. Bloom, D. R. Claes, G. Haza, J. Hossain, C. Joo, I. Kravchenko, J. E. Siado, W. Tabb, A. Vagnerini, A. Wightman, F. Yan, D. Yu, H. Bandyopadhyay, L. Hay, H. w. Hsia, I. Iashvili, A. Kalogeropoulos, A. Kharchilava, M. Morris, D. Nguyen, J. Pekkanen, S. Rappoccio, H. Rejeb Sfar, A. Williams, P. Young, G. Alverson, E. Barberis, J. Bonilla, J. Dervan, Y. Haddad, Y. Han, A. Krishna, J. Li, M. Lu, G. Madigan, R. Mccarthy, D. M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, D. Wood, J. Bueghly, S. Dittmer, K. A. Hahn, Y. Liu, Y. Miao, D. G. Monk, M. H. Schmitt, A. Taliercio, M. Velasco, G. Agarwal, R. Band, R. Bucci, S. Castells, A. Das, R. Goldouzian, M. Hildreth, K. W. Ho, K. Hurtado Anampa, T. Ivanov, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, C. Moore, Y. Musienko, H. Nelson, M. Osherson, A. Piccinelli, R. Ruchti, A. Townsend, Y. Wan, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, A. Basnet, B. Bylsma, M. Carrigan, L. S. Durkin, C. Hill, M. Joyce, M. Nunez Ornelas, K. Wei, B. L. Winer, B. R. Yates, H. Bouchamaoui, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, K. Kennedy, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, D. Stickland, C. Tully, S. Malik, A. S. Bakshi, S. Chandra, R. Chawla, A. Gu, L. Gutay, M. Jones, A. W. Jung, A. M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, V. Scheurer, J. F. Schulte, M. Stojanovic, J. Thieman, A. K. Virdi, F. Wang, A. Wildridge, W. Xie, Y. Yao, J. Dolen, N. Parashar, A. Pathak, D. Acosta, T. Carnahan, K. M. Ecklund, P. J. Fernández Manteca, S. Freed, P. Gardner, F. J. M. Geurts, I. Krommydas, W. Li, J. Lin, O. Miguel Colin, B. P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, Y. Zhang, A. Bodek, P. de Barbaro, R. Demina, J. L. Dulemba, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, N. Parmar, P. Parygin, R. Taus, B. Chiarito, J. P. Chou, S. V. Clark, D. Gadkari, Y. Gershtein, E. Halkiadakis, M. Heindl, C. Houghton, D. Jaroslawski, S. Konstantinou, I. Laflotte, A. Lath, R. Montalvo, K. Nash, J. Reichert, H. Routray, P. Saha, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S. A. Thayil, S. Thomas, J. Vora, H. Wang, D. Ally, A. G. Delannoy, S. Fiorendi, S. Higginbotham, T. Holmes, A. R. Kanuganti, N. Karunarathna, L. Lee, E. Nibigira, S. Spanier, D. Aebi, M. Ahmad, T. Akhter, O. Bouhali, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, N. Gogate, V. Hegde, A. Hussain, Y. Kazhykarim, K. Lamichhane, A. Mankel, T. Peltola, I. Volobouev, E. Appelt, Y. Chen, S. Greene, A. Gurrola, W. Johns, R. Kunnawalkam Elayavalli, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, H. Chung, B. Cox, J. Hakala, R. Hirosky, A. Ledovskoy, C. Neu, P. E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C. K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, L. Pétré, D. Pinna, A. Savin, V. Shang, W. H. Smith, D. Teague, H. F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Alexakhin, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, V. Bunichev, V. Chekhovsky, R. Chistov, M. Danilov, A. Dermenev, T. Dimova, D. Druzhkin, M. Dubinin, L. Dudko, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, O. Kodolova, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, V. Palichik, V. Perelygin, M. Perfilov, S. Petrushanko, S. Polikarpov, V. Popov, O. Radchenko, M. Savina, V. Savrin, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, D. Sosnov, V. Sulimov, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, A. Vorobyev, G. Vorotnikov, N. Voytishin, B. S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: Beyond Standard Model, Hadron-Hadron Scattering, Particle and Resonance Production, Photon Production, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract A search for a new charged particle X with mass between 0.3 and 2.0 TeV decaying to a W boson and a photon is presented, using proton-proton collision data at a center-of-mass energy of 13 TeV, collected by the CMS experiment and corresponding to an integrated luminosity of 138 fb −1. Particle X has electric charge ±1 and is assumed to have spin 0. The search is performed using the electron and muon decays of the W boson. No significant excess above the predicted background is observed. The upper limit at 95% confidence level on the product of the production cross section of the X and its branching fraction to a W boson and a photon is found to be 94 (137) fb for a 0.3 TeV resonance and 0.75 (0.81) fb for a 2.0 TeV resonance, for an X width-to-mass ratio of 0.01% (5%). This search presents the most stringent constraints to date on the existence of such resonances across the probed mass range. A statistical combination with an earlier study based on the hadronic decay mode of the W boson is also performed, and the upper limit at 95% confidence level for a 2.0 TeV resonance is reduced to 0.50 (0.63) fb for an X width-to-mass ratio of 0.01% (5%).
Published: 2024
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34. 3D-Druck in der Wirbelsäulenchirurgie – Update

Author: S. Roth, S. Sehmisch, and S. Decker
Subjects: Emergency Medicine, Orthopedics and Sports Medicine, Surgery
Published: 2022

35. PRC2 Inhibitors Overcome Glucocorticoid Resistance Driven by NSD2 Mutation in Pediatric Acute Lymphoblastic Leukemia

Author: Crissandra Piper, Matthew D. Hall, Marta Kulis, Richard L. Bennett, Alok Swaroop, Min Shen, Richard B. Lock, Jonathan H. Shrimp, Jon A. Oyer, Christine Will, Alberto Riva, Heidi L. Casellas Roman, Duohui Jing, Jianping Li, Catalina Troche, Adolfo A. Ferrando, Jacob S. Roth, Daphné Dupéré-Richer, Jonathan D. Licht, and Julia Cathryn Hlavka-Zhang
Subjects: Mutation, biology, business.industry, medicine.disease_cause, Glucocorticoid receptor, Glucocorticoid Sensitivity, Oncology, In vivo, Cell culture, Histone methyltransferase, medicine, Cancer research, biology.protein, Epigenetics, PRC2, business, hormones, hormone substitutes, and hormone antagonists
Abstract: Mutations in epigenetic regulators are common in relapsed pediatric acute lymphoblastic leukemia (ALL). Here, we uncovered the mechanism underlying the relapse of ALL driven by an activating mutation of the NSD2 histone methyltransferase (p.E1099K). Using high-throughput drug screening, we found that NSD2-mutant cells were specifically resistant to glucocorticoids. Correction of this mutation restored glucocorticoid sensitivity. The transcriptional response to glucocorticoids was blocked in NSD2-mutant cells due to depressed glucocorticoid receptor (GR) levels and the failure of glucocorticoids to autoactivate GR expression. Although H3K27me3 was globally decreased by NSD2 p.E1099K, H3K27me3 accumulated at the NR3C1 (GR) promoter. Pretreatment of NSD2 p.E1099K cell lines and patient-derived xenograft samples with PRC2 inhibitors reversed glucocorticoid resistance in vitro and in vivo. PRC2 inhibitors restored NR3C1 autoactivation by glucocorticoids, increasing GR levels and allowing GR binding and activation of proapoptotic genes. These findings suggest a new therapeutic approach to relapsed ALL associated with NSD2 mutation. Significance: NSD2 histone methyltransferase mutations observed in relapsed pediatric ALL drove glucocorticoid resistance by repression of the GR and abrogation of GR gene autoactivation due to accumulation of K3K27me3 at its promoter. Pretreatment with PRC2 inhibitors reversed resistance, suggesting a new therapeutic approach to these patients with ALL. This article is highlighted in the In This Issue feature, p. 1
Published: 2022

36. Development of an in-house ELISA method for determining the anti-capsid AAV IgG titerin blood donors and hemophilic patients

Author: P Milanov, S Roth, S Rauchfuß, E Seifried, J Schwäble, and W Miesbach
Published: 2023

37. Investigation Of endometriosis symptoms and tumor marker CA 125 in patients With hereditary Von Willebrand disease

Author: J Finger, F Eladly, S Roth, S Rauchfuß, M Tahmasbi Rad, and W Miesbach
Published: 2023

38. Analysis of test beam data taken with a prototype of TPC with resistive Micromegas for the T2K Near Detector upgrade

Author: D. Attié, O. Ballester, M. Batkiewicz-Kwasniak, P. Billoir, A. Blanchet, A. Blondel, S. Bolognesi, R. Boullon, D. Calvet, M.P. Casado, M.G. Catanesi, M. Cicerchia, G. Cogo, P. Colas, G. Collazuol, C. Dalmazzone, T. Daret, A. Delbart, A. De Lorenzis, S. Dolan, K. Dygnarowicz, J. Dumarchez, S. Emery-Schrenk, A. Ershova, G. Eurin, M. Feltre, C. Forza, L. Giannessi, C. Giganti, F. Gramegna, M. Grassi, M. Guigue, P. Hamacher-Baumann, S. Hassani, D. Henaff, F. Iacob, C. Jesús-Valls, S. Joshi, R. Kurjata, M. Lamoureux, A. Langella, J.F. Laporte, L. Lavitola, M. Lehuraux, A. Longhin, T. Lux, L. Magaletti, T. Marchi, L. Mellet, M. Mezzetto, L. Munteanu, Q.V. Nguyen, Y. Orain, M. Pari, J.-M. Parraud, C. Pastore, A. Pepato, E. Pierre, C. Pio Garcia, B. Popov, J. Porthault, H. Przybiliski, F. Pupilli, T. Radermacher, E. Radicioni, F. Rossi, S. Roth, S. Russo, A. Rychter, L. Scomparin, D. Smyczek, J. Steinmann, S. Suvorov, J. Swierblewski, D. Terront, N. Thamm, F. Toussenel, V. Valentino, M. Varghese, G. Vasseur, U. Virginet, U. Yevarouskaya, M. Ziembicki, M. Zito, HEP, INSPIRE, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, irradiation, energy loss, FOS: Physical sciences, KAMIOKANDE, Instrumentation and Detectors (physics.ins-det), near detector: upgrade, time projection chamber, [PHYS.PHYS.PHYS-INS-DET] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], electronics: readout, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Detectors and Experimental Techniques, Resistive micromegas T2K Near Detector Time Projection Chambers, physics.ins-det, spatial resolution, Instrumentation, performance, Micromegas, detector: design
Abstract: In this paper we describe the performance of a prototype of the High Angle Time Projection Chambers (HA-TPCs) that are being produced for the Near Detector (ND280) upgrade of the T2K experiment. The two HA-TPCs of ND280 will be instrumented with eight Encapsulated Resistive Anode Micromegas (ERAM) on each endplate, for a total of 32 ERAMs. This innovative technique allows the detection of the charge emitted by ionization electrons over several pads, improving the determination of the track position. The TPC prototype has been equipped with the first ERAM module produced for T2K and with the HA-TPC readout electronics chain and it has been exposed to an electron beam at DESY in order to measure spatial and dE/dx resolution. In this paper we characterize the performances of the ERAM and, for the first time, we compare them with a newly developed simulation of the detector response. Spatial resolution better than 800 μm and dE/dx resolution better than 10% are observed for all the incident angles and for all the drift distances of interest. All the main features of the data are correctly reproduced by the simulation and these performances fully fulfill the requirements for the HA-TPCs of T2K. In this paper we describe the performance of a prototype of the High Angle Time Projection Chambers (HA-TPCs) that are being produced for the Near Detector (ND280) upgrade of the T2K experiment. The two HA-TPCs of ND280 will be instrumented with eight Encapsulated Resistive Anode Micromegas (ERAM) on each endplate, thus constituting in total 32 ERAMs. This innovative technique allows the detection of the charge emitted by ionization electrons over several pads, improving the determination of the track position. The TPC prototype has been equipped with the first ERAM module produced for T2K and with the HA-TPC readout electronics chain and it has been exposed to the DESY Test Beam in order to measure spatial and dE/dx resolution. In this paper we characterize the performances of the ERAM and, for the first time, we compare them with a newly developed simulation of the detector response. Spatial resolution better than 800 ${\mu \rm m}$ and dE/dx resolution better than 10% are observed for all the incident angles and for all the drift distances of interest. All the main features of the data are correctly reproduced by the simulation and these performances fully fulfill the requirements for the HA-TPCs of T2K.
Published: 2023

39. Cholangiocarcinoma: what are the options in all comers and how has the advent of molecular profiling opened the way to personalised medicine ?

Author: Gael S. Roth, Cindy Neuzillet, Matthieu Sarabi, Julien Edeline, David Malka, Astrid Lièvre, Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Institut Curie [Paris], Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CRLCC Eugène Marquis (CRLCC), Institut Mutualiste de Montsouris (IMM), Oncogenesis, Stress, Signaling (OSS), Université de Rennes (UR)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], and None
Subjects: Cholangiocarcinoma, Cancer Research, Molecular profiling, FGFR2 fusion, Oncology, HER2 amplification, Bile tract cancer, [SDV.CAN]Life Sciences [q-bio]/Cancer, Personnalized medicine, IDH1 mutation
Abstract: International audience; Cholangiocarcinoma is a deadly cancer comprising very heterogenous subtypes with a limited therapeutic arsenal in all comers. However, recent significant advances were made with immunotherapy in the first-line treatment of advanced cholangiocarcinoma, with the addition of durvalumab to cisplatin–gemcitabine chemotherapy showing a survival benefit. In the second line setting, only FOLFOX (5FU/folinic acid-oxaliplatin) is validated by a phase 3 trial, yet with a very modest benefit on survival; new options using 5FU with nanoliposomal-irinotecan may emerge in the next few years. The advent of molecular profiling in advanced cholangiocarcinoma in the last decade revealed frequent targetable alterations such as IDH1 mutations, FGFR2 fusions or rearrangements, HER2 amplification, BRAF V600E mutation and others. This strategy opened the way to personalised medicine for patients which are still fit after first-line treatment and the use of targeted inhibitors in first line constitutes a huge challenge with many ongoing trials to improve patients’ care. This review exposes the recent clinical trial findings in non-molecularly selected advanced cholangiocarcinoma, offers a focus on how systematic molecular screening should be structured to allow patients to access to personalised medicine, and details which are the therapeutic options accessible in case of actionable alteration.
Published: 2023

40. Chapter 15 Trauma: A Dystopia of the Spirit

Author: Michael S. Roth
Published: 2022

41. Immunotherapy in hepatocellular carcinoma: How does underlying liver disease influence therapeutic strategy and outcomes?

Author: Gael S. Roth, François Villeret, Thomas Decaens, Philippe Merle, and Pierre Nahon
Subjects: Hepatology
Abstract: Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide, with up to 90% of HCC cases occurring in the setting of underlying cirrhosis. Therapeutic landscape for advanced HCC has dramatically changed in recent years with the advent of immunotherapy, including several combinations. Data suggest that the surrounding liver milieu may influence tumour response. In addition, different aetiologies of HCC and their effects on the host liver may impact response to immunotherapy. However, to date, guidelines do not take into account this parameter to guide therapeutic selection, and phase III trials are likewise performed in patients irrespective of HCC aetiology. Moreover, most clinical trial data are collected in highly selected patients with preserved liver function (defined as Child-Pugh class A) and controlled portal hypertension, which does not accurately reflect routine clinical practice. In this review, we discuss the influence of liver disease aetiology on the response to immunotherapy in patients with advanced HCC. We also discuss the safety and efficacy of various immunotherapeutic agents in Child-Pugh B patients to determine if these treatments are beneficial in this vulnerable patient population.
Published: 2022

42. Absorbable mesh in a contaminated field: hernia repair outcomes

Author: Victoria Wagner, Brittany E. Levy, Jennifer T. Castle, Margret Plymale, John S. Roth, and Crystal Totten
Subjects: Surgery
Published: 2022

43. No evidence for biased attention towards emotional scenes in Bornean orangutans (Pongo pygmaeus)

Author: D. W. Laméris, E. van Berlo, T. S. Roth, and M. E. Kret
Subjects: General Medicine
Abstract: Attention may be swiftly and automatically tuned to emotional expressions in social primates, as has been demonstrated in humans, bonobos, and macaques, and with mixed evidence in chimpanzees, where rapid detection of emotional expressions is thought to aid in navigating their social environment. Compared to the other great apes, orangutans are considered semi-solitary, but still form temporary social parties in which sensitivity to others’ emotional expressions may be beneficial. The current study investigated whether implicit emotion-biased attention is also present in orangutans (Pongo pygmaeus). We trained six orangutans on the dot-probe paradigm: an established paradigm used in comparative studies which measures reaction time in response to a probe replacing emotional and neutral stimuli. Emotional stimuli consisted of scenes depicting conspecifics having sex, playing, grooming, yawning, or displaying aggression. These scenes were contrasted with neutral scenes showing conspecifics with a neutral face and body posture. Using Bayesian mixed modeling, we found no evidence for an overall emotion bias in this species. When looking at emotion categories separately, we also did not find substantial biases. We discuss the absence of an implicit attention bias for emotional expressions in orangutans in relation to the existing primate literature, and the methodological limitations of the task. Furthermore, we reconsider the emotional stimuli used in this study and their biological relevance.
Published: 2022

44. Structural and Socio-Spatial Determinants Influencing Care and Survival of Patients with a Pancreatic Adenocarcinoma: Results of the PANDAURA Cohort

Author: Gaël S. Roth, Yohan Fayet, Sakina Benmameche-Medjahed, Françoise Ducimetière, Amandine Charreton, Claire Cropet, Sylvie Chabaud, Anne-Marie Marion-Audibert, Olivier Berthelet, Thomas Walter, Mustapha Adham, Mathieu Baconnier, David Tavan, Nicolas Williet, Pascal Artru, Floriane Huet-Penz, Isabelle Ray-Coquard, Fadila Farsi, Hélène Labrosse, and Christelle de la Fouchardière
Subjects: Cancer Research, Oncology, pancreatic adenocarcinoma, socio-spatial disparities, care delays, general practitioner, localized potential accessibility, pancreatic surgery
Abstract: Background and aims: Pancreatic cancer is highly lethal and often diagnosed at an advanced stage. This cohort study analyzes the impact of care pathways, delays, and socio-spatial determinants on pancreatic cancer patients’ diagnosis, treatment, and prognosis. Method: Patients with pancreatic adenocarcinoma newly diagnosed at all stages between January and June 2016 in the AuRA French region were included. The influence on survival of delays of care, healthcare centers’ expertise, and socio-spatial determinants was evaluated. Results: Here, 538 patients were included in 76 centers including 116 patients (21.8%) with resectable, 64 (12.0%) borderline-resectable, 147 (27.6%) locally-advanced tumors, and 205 (38.5%) with metastatic disease. A delay between first symptoms and CT scans did not statistically influence overall survival (OS). In resected patients, OS was significantly higher in centers with more than 20 surgeries (HR 20 surgeries/year p = 0.0081). Regarding socio-spatial determinants, patients living in municipalities with greater access to a general practitioner (HR = 1.673, p = 0.0153) or with a population density below 795.1 people/km2 (HR = 1.881, p = 0.0057) were significantly more often resectable. Conclusion: This cohort study supports the pivotal role of general practitioner in cancer care and the importance of the centralization of pancreatic surgery to optimize pancreatic cancer patients’ care and outcomes. However, delays of care did not impact patient survival.
Published: 2022

45. Neoadjuvante Behandlungskonzepte bei Borderline-resektablem Pankreaskarzinom

Author: S. Roth and M. Schneider
Published: 2022

46. [Neoadjuvant treatment concepts for borderline-resectable adenocarcinoma of the pancreas]

Author: S, Roth and M, Schneider
Subjects: Pancreatic Neoplasms, Humans, Adenocarcinoma, Pancreas, Neoadjuvant Therapy, Carcinoma, Pancreatic Ductal
Published: 2022

47. The influence of prior dental pathology on medical complications and peri-prosthetic joint infections following primary shoulder arthroplasty

Author: Adam M. Gordon, Andrew R. Horn, Keith B. Diamond, Eric S. Roth, Miriam D. Weisberg, Ramin Sadeghpour, and Jack Choueka
Subjects: Orthopedics and Sports Medicine, Surgery
Published: 2022

48. Supernova model discrimination with hyper-kamiokande

Author: Y. Nagao, H. Tanaka, A. Minamino, B. Navarro-Garcia, Z. Xie, L. Nascimento Machado, J. Lagoda, M. Shinoki, S. Cuen-Rochin, Arman Esmaili, F. Ballester, S. Parsa, N. McCauley, Jung-Hyun Kim, K. Frankiewicz, L. L. Kormos, Masaki Ishitsuka, M. Malek, V. Valentino, N. Kazarian, T. Wachala, E. Drakopoulou, G. Grella, V. Paolone, L. F. Thompson, A. K. Tomatani-Sánchez, A. Blanchet, R. A. Wendell, John Ellis, J. Y. Kim, N. W. Prouse, O. V. Mineev, M. R. Vagins, T. Boschi, T. Lindner, J. González-Nuevo, Hiroshi Ito, N. Skrobova, M. La Commara, L. Gialanella, F. Orozco-Luna, T. Kumita, A. Garfagnini, S. H. Jeon, A. Dergacheva, Hiroaki Menjo, A. T. Suzuki, K. Okamoto, C. E. R. Naseby, J. F. Martin, T. Iijima, M. Mezzetto, G. Ricciardi, J. R. Wilson, P. Gumplinger, Y. Takemoto, G. Galinski, K. Zaremba, T. Nakadaira, D. Vivolo, A. Carroll, C. Vilela, A. Blondel, A. Rychter, T. A. Doyle, C. Garde, G. De Rosa, A. Oshlianskyi, Hiroyuki Sekiya, R. Matsumoto, G. Pastuszak, P. J. Rajda, F. Monrabal, Yoichi Asaoka, G. Díaz López, K. L. Stankevich, C. D. Shin, Y. Fukuda, Yuto Ashida, Michal Malinský, T. Suganuma, B. Radics, Kohta Murase, Marco Grassi, P. Mehta, F. Cafagna, Ahmed Ali, L. Koerich, Vincenzo Berardi, Etam Noah, F. J. P. Soler, Alan Cosimo Ruggeri, M. Kekic, G. Vasseur, S. Wronka, M. Thiesse, B. Ferrazzi, K. Iwamoto, Yu. Kudenko, Atsushi Takeda, Kendall Mahn, David Hadley, B. Roskovec, M. Bergevin, A. Korzenev, J.J. Gómez-Cadenas, M. Batkiewicz-Kwasniak, M. Tzanov, M. Ikeda, Federico Sanchez, W. Obrębski, H. S. Jo, Y. Takeuchi, Piotr Kalaczyński, S. Chakraborty, J. C. Nugent, S. King, P. Paganini, M. Miura, F. Ameli, D. N. Yeum, C. J. Metelko, Akito Araya, T. Kajita, M. Tanaka, I. T. Lim, L. Mellet, S. Y. Kim, S. Bolognesi, A. Bravar, J. S. Jang, D. Svirida, A. Fiorentini, J. Renner, M. Chabera, L. O'Sullivan, V. Herrero, F. Iacob, K. Nakamura, Ko Okumura, Lukasz Stawarz, N. Ogawa, Laura Bonavera, Y. Maekawa, Takatomi Yano, Ll. Marti, H. J. Rose, S. El Hedri, L. Maret, G. Zarnecki, L. Bernard, S. H. Seo, H. Nakamura, H. Ozaki, A. P. Kryukov, A. Popov, Hisakazu Minakata, M. Buizza Avanzini, P. Sarmah, K. Martens, Sergio Luis Suárez Gómez, Hiroaki Aihara, V. Lezaun, G. A. Cowan, C. Riccio, S. Garode, R. Akutsu, M. Lamers James, T. Nicholls, I. Alekseev, K. Kowalik, J. Kasperek, T. Zakrzewski, S. B. Kim, T. Kutter, Evan O'Connor, B. Jamieson, F. Nova, M. Barbi, Xianguo Lu, Y. Sonoda, M. Friend, Teppei Katori, L. H. V. Anthony, A. Shaikhiev, C. J. Densham, V. Gousy-Leblanc, I. Bandac, J. H. Choi, S. Sano, A. K. Ichikawa, Magda Cicerchia, S. Valder, S. Roth, J. Kameda, M. Zito, A. Vijayvargi, S. Nakai, Y. Kotsar, K. M. Tsui, K. Hoshina, K. K. Joo, C. Pastore, T. Marchi, K. Niewczas, K. Nakayoshi, G. Fiorillo, C. McGrew, P. F. Loverre, S. Playfer, G.D. Barr, L. Labarga, T. Kobayashi, E. S. Pinzon Guerra, André Rubbia, D. Karlen, Th. A. Mueller, L. Koch, F. J. Mora, M. M. Khabibullin, Hidekazu Kakuno, Yoshitaka Itow, H. K. Tanaka, P. Adrich, Jeong-Eun Lee, S. Samani, M. G. Catanesi, M. Yu, M. J. Wilking, Robert Svoboda, P. Mijakowski, N. Kolev, Yu. Onishchuk, A. Kato, J. M. Poutissou, C. Bronner, Yutaka Nakajima, B. Richards, C. Ruggles, M. Needham, P. Jonsson, Y. Hayato, S. Mine, A. Konaka, L. Munteanu, Kunio Inoue, O. Drapier, Kenneth Long, M. McCarthy, T. Kinoshita, G. Tortone, Yuuki Nakano, T. Feusels, N. Izumi, Reetanjali Moharana, T. Dealtry, S. Hassani, G. Pronost, K. Sakashita, J. G. Learned, H. M. O'Keeffe, Shintaro Ito, E. Rondio, Toru Ogitsu, D. A. Patel, Tatiana Ovsiannikova, M. Guigue, Yusuke Koshio, T. Matsubara, S. M. Stellacci, R. J. Wilkes, G. Santucci, S. Y. Suzuki, S. D. Rountree, K. Zietara, A. A. Quiroga, M. Jakkapu, A. Boiano, L. Berns, M. O. Wascko, M. M. Vyalkov, K. Porwit, M. Taani, A. Evangelisti, I. Sashima, Michal Dziewiecki, J. Feng, Y. Seiya, M. Yonenaga, B. Spisso, B. W. Pointon, C. M. Mollo, N. Booth, S. V. Cao, N. Ospina, A. J. Finch, V. Takhistov, E. Radicioni, P. Przewlocki, S. Nakayama, S. Yen, T. Sekiguchi, Yudai Suwa, J. M. Calvo-Mozota, S. Zsoldos, C. Checchia, M. Posiadala-Zezula, E. O'Sullivan, Janusz Marzec, F. Retiere, Jan T. Sobczyk, P. Migliozzi, S. Borjabad, I. Di Palma, John Hill, K. A. Kouzakov, D. L. Wark, L. Cook, D. Sgalaberna, E. W. Miller, M. Lamoureux, M. Y. Pac, S. Russo, S. L. Cartwright, Yasunari Suzuki, D. Bose, B. Zaldivar, D. Martin, Dongsu Ryu, Z. Shan, S. Miki, M. Jiang, J. Kisiel, N. Yershov, M. Matusiak, C. Pea-Garay, K. Sato, Jesús Daniel Santos, Y. Yamaguchi, D. Bravo-Berguo, Chad Finley, T. Tashiro, Lawrence D. Brown, A. Gorin, Hiromasa Tanaka, M. Ziembicki, T. Vladisavljevic, J. Zalipska, J. Insler, C. Yanagisawa, Abinash Medhi, L. Kravchuk, W. Idrissi Ibnsalih, Hirokazu Ishino, J. Bian, K. Magar, S. Cebrian, Philippe Mermod, R. Gornea, Juan Pedro Ochoa-Ricoux, Sergei Fedotov, S. Izumiyama, C. Bozza, R. Esteve, Seiko Hirota, T. Tsukamoto, K. Skwarczynski, E. De la Fuente, T. Kikawa, M. Gonin, J. Xia, Intae Yu, Gareth J. Barker, A. Marinelli, E. Kearns, L. Lavitola, Michal Ostrowski, N. Deshmukh, Y. Kataoka, F. d. M. Blaszczyk, Carsten Rott, C. Mariani, T. Ishida, Roberto Spina, J. W. Seo, Masashi Yokoyama, F. Gramegna, K. Hultqvist, G. Collazuol, P. Spradlin, Gus Sinnis, A. Takenaka, T. Xin, M. Bellato, Yuki Fujii, Mark Scott, J. A. Hernando-Morata, P. Ferrario, A. Buchowicz, S. J. Jenkins, J. Walker, J. Toledo, Pablo Fernandez, Sandhya Choubey, S. Emery, A. Mefodiev, R.P. Kurjata, M. Mongelli, J. Dumarchez, Tsuyoshi Nakaya, M. Antonova, M. Danilov, M. Feely, A. Holin, Ara Ioannisian, B. A. Popov, K Stopa, W. G. S. Vinning, M. L. Sánchez, Masato Shiozawa, L. Ludovici, J. Gao, S. Bhadra, Koji Ishidoshiro, Hiroshi Nunokawa, V. Aushev, M. Hartz, I. Shimizu, C. S. Moon, M. B. Smy, S. Matsuno, I. Anghel, J. Migenda, T. Mondal, F. Di Lodovico, M. Tada, D. J. Payne, M. Kuze, N. C. Hastings, P. Di Meo, Y. Nishimura, M. Inomoto, L. Magaletti, C. Giganti, A. Klekotko, Patrick Dunne, J. Yoo, M. C. Sanchez, A. N. Khotjantsev, Kyujin Kwak, Lars Eklund, M. Lawe, A. Mitra, H. W. Sobel, Jürgen Pozimski, Yasuhiro Makida, A. Bubak, Jaroslaw Pasternak, B. Quilain, R. Leitner, Marco Laveder, J. P. Coleman, N. F. Calabria, H. I. Jang, S. B. Boyd, Moon Moon Devi, M. Fitton, M. Harada, Artur F. Izmaylov, J. McElwee, Shunsaku Horiuchi, P. de Perio, K. Nakagiri, Y. Kano, M. Rescigno, S. Moriyama, Masayuki Nakahata, C. Pidcott, Y. Uchida, V. Palladino, A. Longhin, A. Shaykina, Michelangelo Pari, Akimichi Taketa, Yuichi Oyama, S. Suvorov, R. P. Litchfield, D. H. Moon, Katsuki Hiraide, M. Pavin, M. Koga, R. B. Vogelaar, Enrique Fernandez-Martinez, B. L. Hartfiel, Koji Yamamoto, K. Ohta, K. Abe, Alexander Studenikin, E. Mazzucato, Elisa Bernardini, Abe, K., Adrich, P., Aihara, H., Akutsu, R., Alekseev, I., Ali, A., Ameli, F., Anghel, I., Anthony, L. H. V., Antonova, M., Araya, A., Asaoka, Y., Ashida, Y., Aushev, V., Ballester, F., Bandac, I., Barbi, M., Barker, G. J., Barr, G., Batkiewicz-Kwasniak, M., Bellato, M., Berardi, V., Bergevin, M., Bernard, L., Bernardini, E., Berns, L., Bhadra, S., Bian, J., Blanchet, A., Blaszczyk, F. D. M., Blondel, A., Boiano, A., Bolognesi, S., Bonavera, L., Booth, N., Borjabad, S., Boschi, T., Bose, D., Boyd, S. B., Bozza, C., Bravar, A., Bravo-Berguo, D., Bronner, C., Brown, L., Bubak, A., Buchowicz, A., Buizza Avanzini, M., Cafagna, F. S., Calabria, N. F., Calvo-Mozota, J. M., Cao, S., Cartwright, S. L., Carroll, A., Catanesi, M. G., Cebrian, S., Chabera, M., Chakraborty, S., Checchia, C., Choi, J. H., Choubey, S., Cicerchia, M., Coleman, J., Collazuol, G., Cook, L., Cowan, G., Cuen-Rochin, S., Danilov, M., Diaz Lopez, G., De La Fuente, E., De Perio, P., De Rosa, G., Dealtry, T., Densham, C. J., Dergacheva, A., Deshmukh, N., Devi, M. M., Di Lodovico, F., Di Meo, P., Di Palma, I., Doyle, T. A., Drakopoulou, E., Drapier, O., Dumarchez, J., Dunne, P., Dziewiecki, M., Eklund, L., El Hedri, S., Ellis, J., Emery, S., Esmaili, A., Esteve, R., Evangelisti, A., Feely, M., Fedotov, S., Feng, J., Fernandez, P., Fernandez-Martinez, E., Ferrario, P., Ferrazzi, B., Feusels, T., Finch, A., Finley, C., Fiorentini, A., Fiorillo, G., Fitton, M., Frankiewicz, K., Friend, M., Fujii, Y., Fukuda, Y., Galinski, G., Gao, J., Garde, C., Garfagnini, A., Garode, S., Gialanella, L., Giganti, C., Gomez-Cadenas, J. J., Gonin, M., Gonzalez-Nuevo, J., Gorin, A., Gornea, R., Gousy-Leblanc, V., Gramegna, F., Grassi, M., Grella, G., Guigue, M., Gumplinger, P., Hadley, D. R., Harada, M., Hartfiel, B., Hartz, M., Hassani, S., Hastings, N. C., Hayato, Y., Hernando-Morata, J. A., Herrero, V., Hill, J., Hiraide, K., Hirota, S., Holin, A., Horiuchi, S., Hoshina, K., Hultqvist, K., Iacob, F., Ichikawa, A. K., Idrissi Ibnsalih, W., Iijima, T., Ikeda, M., Inomoto, M., Inoue, K., Insler, J., Ioannisian, A., Ishida, T., Ishidoshiro, K., Ishino, H., Ishitsuka, M., Ito, H., Ito, S., Itow, Y., Iwamoto, K., Izmaylov, A., Izumi, N., Izumiyama, S., Jakkapu, M., Jamieson, B., Jang, H. I., Jang, J. S., Jenkins, S. J., Jeon, S. H., Jiang, M., Jo, H. S., Jonsson, P., Joo, K. K., Kajita, T., Kakuno, H., Kameda, J., Kano, Y., Kalaczynski, P., Karlen, D., Kasperek, J., Kataoka, Y., Kato, A., Katori, T., Kazarian, N., Kearns, E., Khabibullin, M., Khotjantsev, A., Kikawa, T., Kekic, M., Kim, J. H., Kim, J. Y., Kim, S. B., Kim, S. Y., King, S., Kinoshita, T., Kisiel, J., Klekotko, A., Kobayashi, T., Koch, L., Koga, M., Koerich, L., Kolev, N., Konaka, A., Kormos, L. L., Koshio, Y., Korzenev, A., Kotsar, Y., Kouzakov, K. A., Kowalik, K. L., Kravchuk, L., Kryukov, A. P., Kudenko, Y., Kumita, T., Kurjata, R., Kutter, T., Kuze, M., Kwak, K., La Commara, M., Labarga, L., Lagoda, J., Lamers James, M., Lamoureux, M., Laveder, M., Lavitola, L., Lawe, M., Learned, J. G., Lee, J., Leitner, R., Lezaun, V., Lim, I. T., Lindner, T., Litchfield, R. P., Long, K. R., Longhin, A., Loverre, P., Lu, X., Ludovici, L., Maekawa, Y., Magaletti, L., Magar, K., Mahn, K., Makida, Y., Malek, M., Malinsky, M., Marchi, T., Maret, L., Mariani, C., Marinelli, A., Martens, K., Marti, L., Martin, J. F., Martin, D., Marzec, J., Matsubara, T., Matsumoto, R., Matsuno, S., Matusiak, M., Mazzucato, E., Mccarthy, M., Mccauley, N., Mcelwee, J., Mcgrew, C., Mefodiev, A., Medhi, A., Mehta, P., Mellet, L., Menjo, H., Mermod, P., Metelko, C., Mezzetto, M., Migenda, J., Migliozzi, P., Mijakowski, P., Miki, S., Miller, E. W., Minakata, H., Minamino, A., Mine, S., Mineev, O., Mitra, A., Miura, M., Moharana, R., Mollo, C. M., Mondal, T., Mongelli, M., Monrabal, F., Moon, D. H., Moon, C. S., Mora, F. J., Moriyama, S., Mueller, T. A., Munteanu, L., Murase, K., Nagao, Y., Nakadaira, T., Nakagiri, K., Nakahata, M., Nakai, S., Nakajima, Y., Nakamura, K., Nakamura, K. I., Nakamura, H., Nakano, Y., Nakaya, T., Nakayama, S., Nakayoshi, K., Nascimento Machado, L., Naseby, C. E. R., Navarro-Garcia, B., Needham, M., Nicholls, T., Niewczas, K., Nishimura, Y., Noah, E., Nova, F., Nugent, J. C., Nunokawa, H., Obrebski, W., Ochoa-Ricoux, J. P., O'Connor, E., Ogawa, N., Ogitsu, T., Ohta, K., Okamoto, K., O'Keeffe, H. M., Okumura, K., Onishchuk, Y., Orozco-Luna, F., Oshlianskyi, A., Ospina, N., Ostrowski, M., O'Sullivan, E., O'Sullivan, L., Ovsiannikova, T., Oyama, Y., Ozaki, H., Pac, M. Y., Paganini, P., Palladino, V., Paolone, V., Pari, M., Parsa, S., Pasternak, J., Pastore, C., Pastuszak, G., Patel, D. A., Pavin, M., Payne, D., Pea-Garay, C., Pidcott, C., Pinzon Guerra, E., Playfer, S., Pointon, B. W., Popov, A., Popov, B., Porwit, K., Posiadala-Zezula, M., Poutissou, J. -M., Pozimski, J., Pronost, G., Prouse, N. W., Przewlocki, P., Quilain, B., Quiroga, A. A., Radicioni, E., Radics, B., Rajda, P. J., Renner, J., Rescigno, M., Retiere, F., Ricciardi, G., Riccio, C., Richards, B., Rondio, E., Rose, H. J., Roskovec, B., Roth, S., Rott, C., Rountree, S. D., Rubbia, A., Ruggeri, A. C., Ruggles, C., Russo, S., Rychter, A., Ryu, D., Sakashita, K., Samani, S., Sanchez, F., Sanchez, M. L., Sanchez, M. C., Sano, S., Santos, J. D., Santucci, G., Sarmah, P., Sashima, I., Sato, K., Scott, M., Seiya, Y., Sekiguchi, T., Sekiya, H., Seo, J. W., Seo, S. H., Sgalaberna, D., Shaikhiev, A., Shan, Z., Shaykina, A., Shimizu, I., Shin, C. D., Shinoki, M., Shiozawa, M., Sinnis, G., Skrobova, N., Skwarczynski, K., Smy, M. B., Sobczyk, J., Sobel, H. W., Soler, F. J. P., Sonoda, Y., Spina, R., Spisso, B., Spradlin, P., Stankevich, K. L., Stawarz, L., Stellacci, S. M., Stopa, K., Studenikin, A. I., Suarez Gomez, S. L., Suganuma, T., Suvorov, S., Suwa, Y., Suzuki, A. T., Suzuki, S. Y., Suzuki, Y., Svirida, D., Svoboda, R., Taani, M., Tada, M., Takeda, A., Takemoto, Y., Takenaka, A., Taketa, A., Takeuchi, Y., Takhistov, V., Tanaka, H., Tanaka, H. A., Tanaka, H. I., Tanaka, M., Tashiro, T., Thiesse, M., Thompson, L. F., Toledo, J., Tomatani-Sanchez, A. K., Tortone, G., Tsui, K. M., Tsukamoto, T., Tzanov, M., Uchida, Y., Vagins, M. R., Valder, S., Valentino, V., Vasseur, G., Vijayvargi, A., Vilela, C., Vinning, W. G. S., Vivolo, D., Vladisavljevic, T., Vogelaar, R. B., Vyalkov, M. M., Wachala, T., Walker, J., Wark, D., Wascko, M. O., Wendell, R. A., Wilkes, R. J., Wilking, M. J., Wilson, J. R., Wronka, S., Xia, J., Xie, Z., Xin, T., Yamaguchi, Y., Yamamoto, K., Yanagisawa, C., Yano, T., Yen, S., Yershov, N., Yeum, D. N., Yokoyama, M., Yonenaga, M., Yoo, J., Yu, I., Yu, M., Zakrzewski, T., Zaldivar, B., Zalipska, J., Zaremba, K., Zarnecki, G., Ziembicki, M., Zietara, K., Zito, M., Zsoldos, S., Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Hyper-Kamiokande, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Physics - Instrumentation and Detectors, 09.- Desarrollar infraestructuras resilientes, promover la industrialización inclusiva y sostenible, y fomentar la innovación, KAMIOKANDE, Astrophysics, 01 natural sciences, neutrino: flux, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), neutrino, accretion, black hole, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Core-collapse supernovae, neutron star, Monte Carlo, physics.ins-det, 010303 astronomy & astrophysics, astro-ph.HE, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, Instrumentation and Detectors (physics.ins-det), 16. Peace & justice, Supernova, neutrino: detector, 07.- Asegurar el acceso a energías asequibles, fiables, sostenibles y modernas para todos, supernova, neutrino astronomy, neutrino physics, Neutrino detector, Neutrino, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, supernova: collapse, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Observable universe, Astrophysics::Cosmology and Extragalactic Astrophysics, Hyper-Kamiokande, 0103 physical sciences, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], High energy physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), High Energy Astrophysical Phenomena, Astrophysics::Galaxy Astrophysics, hep-ex, 010308 nuclear & particles physics, supernova: model, Astronomy and Astrophysics, Galaxy, Black hole, Neutron star, Space and Planetary Science, neutrino: burst, galaxy, Neutrino astronomy, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], astro-ph.IM
Abstract: Autorzy: Abe K., Adrich P., Aihara H., Akutsu, R., Alekseev I., Ali A. , Ameli F., Anghel I., Anthony L. H. V., Antonova M. , Araya A., Asaoka Y., Ashida Y., Aushev V., Ballester F., Bandac I., Barbi M., Barker G. J., Barr G., Batkiewicz-Kwasniak M., Bellato M., Berardi V., Bergevin M., Bernard L., Bernardini E., Berns L., Bhadra S., Bian J., Blanchet A., Blaszczyk F. d. M., Blonde A., Boiano A., Bolognesi S., Bonavera L., Booth N., Borjabad S., Boschi, T., Bose D., Boyd S . B., Bozza C., Bravar A., Bravo-Berguño D., Bronner C., Brown L., Bubak Arkadiusz, Buchowicz A., Buizza Avanzini M., Cafagna F. S., Calabria N. F., Calvo-Mozota J. M., Cao S., Cartwright S.L., Carroll A., Catanesi M. G., Cebriàn, S., Chabera M., Chakraborty, S., Checchia C., Choi J.H., Choubey S., Cicerchia M., Coleman J., Collazuol G., Cook L., Cowan G., Cuen-Rochin, S., Danilov M., Díaz López G., De la Fuente E., de Perio P., De Rosa G., Dealtry T., Densham C. J., Dergacheva A., Deshmukh N., Devi M. M., Di Lodovico F., Di Meo, P., Di Palma I., Doyle T. A., Drakopoulou E., Drapier O., Dumarchez J., Dunne P., Dziewiecki M., Eklund L., El Hedri S., Ellis J., Emery S., Esmaili A., Esteve R., Evangelisti A., Feely M., Fedotov S., Feng J., Fernandez P., Fernández-Martinez E., Ferrario P., Ferrazzi,B., Feusels T., Finch A., Finley C., Fiorentini A., Fiorillo G., Fitton M., Frankiewicz K., Friend M., Fujii Y., Fukuda Y., Galinski G., Gao J., Garde C., Garfagnini A., Garode S., Gialanella L., Giganti C., Gomez-Cadenas J.J., Gonin M., González-Nuevo J., Gorin A., Gornea R., Gousy-Leblanc V. Gramegna F. Grassi M. Grella G. Guigue M. Gumplinger P. Hadley D.R. Harada M., Hartfiel B., Hartz M., Hassani S., Hastings N.C., Hayato Y., Hernando-Morata J.A., Herrero V., Hill J., Hiraide K., Hirota S., Holin A., Horiuchi S., Hoshina K., Hultqvist K., Iacob F., Ichikawa A.K., Idrissi Ibnsalih W., Iijima T., Ikeda M., Inomoto M., Inoue K., Insler J., Ioannisian A., Ishida T., Ishidoshiro K., Ishino H., Ishitsuka M., Ito H., Ito S., Itow Y., Iwamoto K., Izmaylov A., Izumi N., Izumiyama S., Jakkapu M., Jamieson B., Jang H.I., Jang J.S., Jenkins S.J., Jeon S.H., Jiang M., Jo H.S., Jonsson P., Joo K.K., Kajita T., Kakuno H., Kameda J., Kano Y., Kalaczynski P., Karlen D., Kasperek J., Kataoka Y., Kato A., Katori T., Kazarian N., Kearns E., Khabibullin M., Khotjantsev A., Kikawa T., Kekic M., Kim J.H., Kim J.Y., Kim S.B., Kim S.Y., King S., Kinoshita T., Kisiel Jan, Klekotko A., Kobayashi T., Koch L., Koga M., Koerich L., Kolev N., Konaka A., Kormos L.L., Koshio Y., Korzenev A., Kotsar Y., Kouzakov K.A., Kowalik K.L., Kravchuk L., Kryukov A.P., Kudenko Y., Kumita T., Kurjata R., Kutter T., Kuze M., Kwak K., La Commara M., Labarga L., Lagoda J., Lamers James J., Lamoureux M., Laveder M., Lavitola L., Lawe M., Learned J.G., Lee J., Leitner R., Lezaun V., Lim I.T., Lindner T., Litchfield R.P., Long K.R., Longhin A., Loverre P., Lu X., Ludovici L., Maekawa Y., Magaletti L., Magar K., Mahn K., Makida Y., Malek M., Malinský M., Marchi T., Maret L., Mariani C., Marinelli A., Martens K., Marti L., Martin J.F. Martin D., Marzec J., Matsubara T., Matsumoto R., Matsuno S., Matusiak M., Mazzucato E., McCarthy M., McCauley N., McElwee J., McGrew C., Mefodiev A., Medhi A., Mehta P., Mellet L., Menjo H., Mermod P., Metelko C., Mezzetto M., Migenda J., Migliozzi P., Mijakowski P., Miki S., Miller E.W., Minakata H., Minamino A., Mine S., Mineev O., Mitra A., Miura M., Moharana R., Mollo C.M., Mondal T., Mongelli M., Monrabal F., Moon D.H., Moon C.S., Mora F.J., Moriyama S., Mueller Th.A., Munteanu L., Murase K., Nagao Y., Nakadaira T., Nakagiri K., Nakahata M., Nakai S., Nakajima Y., Nakamura K., Nakamura KI., Nakamura H., Nakano Y., Nakaya T., Nakayama S., Nakayoshi K., Nascimento Machado L., Naseby C.E.R., Navarro-Garcia B., Needham M., Nicholls T., Niewczas K., Nishimura Y., Noah E., Nova F., Nugent J.C., Nunokawa H., Obrebski W., Ochoa-Ricoux J.P., O’Connor E., Ogawa N., Ogitsu T., Ohta K., Okamoto K., O’Keeffe H.M., Okumura K., Onishchuk Y., Orozco-Luna F., Oshlianskyi A., Ospina N., Ostrowski M., O’Sullivan E., O’Sullivan L., Ovsiannikova T., Oyama Y., Ozaki H., Pac M.Y., Paganini P., Palladino V., Paolone V., Pari M., Parsa S., Pasternak J., Pastore C., Pastuszak G., Patel D.A., Pavin M., Payne D., Peña-Garay C., Pidcott C., Pinzon Guerra E., Playfer S., Pointon B.W., Popov A., Popov B., Porwit Kamil, Posiadala-Zezula M., Poutissou J.M., Pozimski J., Pronost G., Prouse N.W., Przewlocki P., Quilain B., Quiroga A.A., Radicioni E., Radics B., Rajda P.J., Renner J., Rescigno M., Retiere F., Ricciardi G., Riccio C., Richards B., Rondio E., Rose H.J., Roskovec B., Roth S., Rott C., Rountree S.D., Rubbia A., Ruggeri A.C., Ruggles C., Russo S., Rychter A., Ryu D., Sakashita K., Samani S., Sánchez F., Sánchez M.L., Sanchez M.C., Sano S., Santos J.D., Santucci G., Sarmah P., Sashima I., Sato K., Scott M., Seiya Y., Sekiguchi T., Sekiya H., Seo J.W., Seo S.H., Sgalaberna D., Shaikhiev A., Shan Z., Shaykina A., Shimizu I., Shin C.D., Shinoki M., Shiozawa M., Sinnis G., Skrobova N., Skwarczynski K., Smy M.B., Sobczyk J., Sobel H.W., Soler F. J. P., Sonoda Y., Spina R., Spisso B., Spradlin B., Stankevich K.L., Stawarz L., Stellacci S.M., Stopa K., Studenikin A.I., Suárez Gómez S.L., Suganuma T., Suvorov S., Suwa Y., Suzuki A.T., Suzuki S.Y., Suzuki Y., Svirida D., Svoboda R., Taani M., Tada M., Takeda A., Takemoto Y., Takenaka A., Taketa A., Takeuchi Y., Takhistov V., Tanaka H., Tanaka H.A., Tanaka H.I., Tanaka M., Tashiro T., Thiesse M., Thompson L.F., Toledo J., Tomatani-Sánchez A.K., Tortone G., Tsui K.M., Tsukamoto T., Tzanov M., Uchida Y., Vagins M.R., Valder S., Valentino V., Vasseur G., Vijayvargi A., Vilela C., Vinning W. G. S., Vivolo D., Vladisavljevic T., Vogelaar R.B., Vyalkov M.M., Wachala T., Walker J., Wark D., Wascko M.O., Wendell R.A., Wilkes R.J., Wilking M.J., Wilson M.R., Wronka S., Xia J., Xie Z., Xin T., Yamaguchi Y., Yamamoto K., Yanagisawa C., Yano T., Yen S., Yershov N., Yeum D.N., Yokoyama M., Yonenaga M., Yoo J., Yu I., Yu M., Zakrzewski T., Zaldivar B., Zalipska J., Zaremba K., Zarnecki G., Ziembicki M., Zietara K., Zito M., Zsoldos S., Core-collapse supernovae are among the most magnificent events in the observable universe. They produce many of the chemical elements necessary for life to exist and their remnants-neutron stars and black holes-are interesting astrophysical objects in their own right. However, despite millennia of observations and almost a century of astrophysical study, the explosion mechanism of core-collapse supernovae is not yet well understood. Hyper-Kamiokande is a next-generation neutrino detector that will be able to observe the neutrino flux from the next galactic core-collapse supernova in unprecedented detail. We focus on the first 500 ms of the neutrino burst, corresponding to the accretion phase, and use a newly-developed, high-precision supernova event generator to simulate Hyper-Kamiokandeʼs response to five different supernova models. We show that Hyper-Kamiokande will be able to distinguish between these models with high accuracy for a supernova at a distance of up to 100 kpc. Once the next galactic supernova happens, this ability will be a powerful tool for guiding simulations toward a precise reproduction of the explosion mechanism observed in nature.
Published: 2022

49. [Long-term outcomes after resection of non-functional pancreatic neuroendocrine tumors]

Author: S, Roth and M A, Schneider
Subjects: Pancreatic Neoplasms, Neuroendocrine Tumors, Humans
Published: 2022

50. [Artificial intelligence for determining the optimal tumor-free resection margin in colorectal liver metastases]

Author: S, Roth and M, Schneider
Subjects: Artificial Intelligence, Liver Neoplasms, Hepatectomy, Humans, Margins of Excision, Colorectal Neoplasms
Published: 2022

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