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To investigate the changing trends in the prevalence of schistosomiasis in Anhui Province from 2004 to 2020, so as to provide the evidence for formulating the schistosomiasis elimination strategy in the province.The epidemiological data of schistosomiasis in Anhui Province from 2004 to 2020 were collected, and the trends in the endemic status of schistosomiasis were analyzed using a Joinpoint regression model. The trends in the prevalence ofThe prevalence ofThe prevalence of

Two new mixed-ligand coordination polymers of Cd(II), namely, [Cd(H2L)(ip)H2O]n (1) and [Cd(H2L)(Hbtc)]n (2) [H2L = 3-(1H-pyrazol-4-yl)-5-(pyridin-2-yl)-1,2,4-triazole, H2ip = isophthalic acid, H3btc = 1,3,5-benzenetricarboxylic acid], have been hydrothermally synthesized and characterized by elemental analysis, IR spectra, powder X-ray diffraction, and single-crystal X-ray diffraction. Compound 1 displays a one-dimensional chain structure, which upon hydrogen bonding generates 3D supramolecular framework. Compound 2 exhibits a one-dimensional double-chain structure connected by hydrogen bonds with formation of 2D supramolecular framework. Fluorescent properties of two compounds have been studied in the solid state at room temperature.

We studied the effects and mechanisms of action of conophylline in different concentrations in the original in vitro model of myocardial fibrosis (treatment of cardiac fibroblasts isolated form the hearts of newborn rats with angiotensin II). Viability, collagen content, and expression of related protein in cardiac fibroblasts were assessed using the MTT-test, Sircol assay, and Western blotting, respectively. Conophylline markedly protected the cultured cells against the development of angiotensin II-induced fibrosis, which was seen from reduced viability of fibroblasts, decreased collagen content, and down-regulation of the expression of α-smooth muscle actin (α-SMA). Conophylline did not affect the TGF-β pathway altered by angiotensin II, but markedly decreased the level of bone morphogenetic protein-4 (BMP4) enhanced by angiotensin II and BMP4 itself. Conophylline produced no effect on phosphorylation of α-SMA and Smad homologue-1/5/8, the classic BMP4 downstream pathway elements, but reduced the level of c-Jun N-terminal kinase (JNK) elevated by BMP4. Conophylline did not inhibit the development of myocardial fibrosis in the presence of JNK activator anisomycin. Thus, conophylline inhibited angiotensin II-provoked myocardial fibrosis via the BMP4/JNK pathway.

Preventive chemotherapy is one of the pivotal interventions for the control and elimination of schistosomiasis, which is effective to reduce the morbidity and prevalence of schistosomiasis. In order to promote the United Nations' sustainable development goals and the targets set for schistosomiasis control in the

To analyze the spatial-temporal distribution characteristics ofThe actual area of snail habitats gradually decreased in Anhui Province from 2011 to 2020. The actual area of snail habitats were 26 238.85 hmThere were spatial clusters in the distribution of

Currently, the national schistosomiasis control program of China is moving from transmission interruption to elimination, and there are multiple challenges during the stage moving towards the progression of schistosomiasis elimination, including a high difficulty in shrinking snail-infested areas, unstable achievements for infectious source control, imperfect surveillance system and a reduction in schistosomiasis control and administration. Based on the core suggestions proposed in the 2022 WHO guideline on control and elimination of human schistosomiasis, recommendations on schistosomiasis surveillance system building, development of novel diagnostics, adjustment of the schistosomiasis control strategy and maintaining and improvements of the schistosomiasis control capability are proposed for the national schistosomiasis control program of China in the new era according to the actual status of schistosomiasis control in China. Formulation of the national schistosomiasis control strategy and goal from One Health perspective, verification of transmission interruption and elimination of schistosomiasis, precision implementation of schistosomiasis control interventions with adaptations to local circumstances, development and application of highly sensitive and specific diagnostics are recommended for elimination of schistosomiasis in China. In addition, the implementation of the 2022 WHO guideline on control and elimination of human schistosomiasis may guide the elimination of schistosomiasis in China.

As a non-destructive technique, Acoustic emission (AE) can be employed to detect the damage inside the material passively and then locate the damage source. However, fatigue loading poses challenges to AE signal acquisition and processing. In this paper, AE monitoring is performed on glass fiber/epoxy composite laminates under fatigue loads. Due to the intrinsic noise, wavelet packet decomposition is used for noise elimination. Results show that the noise components in original AE signals can be effectively eliminated by the wavelet analysis. Based on the difference of the arrival times, the line positioning method is shown to locate AE sources appearing in the laminates successfully. The peak frequency characteristic of each AE signal is utilized for damage mode classification. The fracture of the laminate is governed by delamination and fiber/breakage, followed by fiber/matrix interface debonding.

Glaucoma is a serious irreversible blinding disease. The pathogenesis is still unknown, and the diagnosis and treatment effect is not good. An effective early diagnosis method is urgently needed. In recent years, a number of glaucoma-related biomarkers have been discovered. In order to promote clinical application of these biomarkers, a series of studies are actively carried out to clarify specificity and sensitivity of these molecules, to verify the criteria by clinical randomized controlled trials, and to provide large sample data by multi-center clinical trials. However, the samples of these biomarkers are provided by patients who have been diagnosed with glaucoma by clinical examinations. The differences may represent the molecular features of middle-stage and advanced glaucoma. Whether they are helpful for early diagnosis and the exploration of pathological mechanisms should be further investigated. This article describes the potential molecular targets that can help in diagnosis of glaucoma from the aspects of DNA, RNA and protein, and discusses further research pathways and clinical application prospects. It is hoped to explore the effective molecular marker for early diagnosis of glaucoma.青光眼是一类严重的不可逆性致盲眼病，至今病因未明，诊疗效果不佳，亟需有效的早期诊断方案。近年，众多青光眼相关生物标志物被发现，为促进临床应用一系列研究正在积极开展。但目前获得的生物标志物样本来自临床已确诊为青光眼的患者，即这些生物标志物的改变可能是中晚期青光眼的分子生物学特征，对青光眼的早期诊断及其病理机制的阐明是否有帮助仍有待探讨。本文从DNA、RNA、蛋白质等方面阐述可以帮助青光眼诊断的潜在分子靶标，并讨论其进一步的研究路径，希望从分子水平为青光眼的早期诊断探寻靶点。

Possible bound nuclei beyond the two-neutron drip line in the $50\ensuremath{\le}Z\ensuremath{\le}70$ region are investigated by using the deformed relativistic Hartree-Bogoliubov theory in continuum with density functional PC-PK1. Bound nuclei beyond the drip lines of $_{56}\mathrm{Ba}$, $_{58}\mathrm{Ce}$, $_{62}\mathrm{Sm}$, $_{64}\mathrm{Gd}$, and $_{66}\mathrm{Dy}$ are predicted, forming peninsulas of stability in the nuclear landscape. Near these peninsulas, several multineutron emitters are predicted. The underlying mechanism of the peninsulas of stability is investigated by studying the total energy, Fermi surface, quadrupole deformation, and the single-neutron spectrum in the canonical basis. It is found that the deformation effect is crucial for forming the peninsulas of stability, and pairing correlations are also essential in specific cases. The dependence on the deformation evolution is also discussed. The decay rates of multineutron radioactivity in Ba and Sm isotopic chains are estimated by using the direct decay model.

Surveillance is an important part of the national schistosomiasis control program of China, which play a critical role in facilitating the progress towards elimination of schistosomiasis in China. The coverage of schistosomiasis surveillance has shifted from the high-risk regions at the initial stage of the national schistosomiasis control program of China to the current all endemic counties (cities, districts), and the surveillance contents have extended from single surveillance of endemic status to comprehensive surveillance of endemic status, epidemic factors and transmission risks. With the continuous progress towards schistosomiasis elimination, the national schistosomiasis control program has shifted from "extensive control" to surveillance and early warning-based "precision control" in China, which proposes much higher requirements for schistosomiasis surveillance. Currently, the surveillance of schistosomiasis has been covered in all schistosomiasis-endemic counties (cities, districts) of China, and the development of rapid and early identification of

Osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) is vital for bone formation, and its dysfunction is linked to osteoporosis (OP). In this work, we explored the function of long non-coding RNA (lncRNA) small nucleolar RNA host gene 14 (SNHG14) in regulating osteogenic differentiation of hBMSCs. In the present study, the expression of SNHG14 in hBMSCs obtained from OP patients was measured by quantitative real-time polymerase chain reaction (qRT-PCR). SNHG14 was over-expressed or knocked down in hBMSCs, and the expression levels of OP-related genes (ALP, OCN, and OPN) in hBMSCs were detected by qRT-PCR and Western blot. StarBase database and miRanda database were used to predict the binding sites between SNHG14 and miR-185-5p, and between miR-185-5p and 3'UTR of WNT1 inducible signaling pathway protein 2 (WISP2), respectively. Luciferase reporter gene assay was used to validate the binding relationship between SNHG14 and miR-185-5p, and miR-185-5p and 3'UTR of WISP2, respectively. Here, we report that SNHG14 was significantly down-regulated in hBMSCs obtained from patients with OP. Overexpression of SNHG14 promoted osteogenic differentiation, while knockdown of SNHG14 worked oppositely. Mechanistically, miR-185-5p was demonstrated to be a target of SNHG14, and could reverse the function of SNHG14. Additionally, WISP2 was identified as a target gene of miR-185-5p in hBMSCs and could be indirectly regulated by SNHG14. Taken together, down-regulation of SNHG14 in hBMSCs accelerated the progression of OP via regulating miR-185-5p/WISP2 axis.

Since 2015 when the transmission of schistosomiasis was controlled in China, the country has been moving towards elimination of schistosomiasis, with the surveillance

New transitions in neutron rich $^{100}$Y have been identified in a $^9$Be+$^{238}$U experiment with mass- and Z- gates to provide full fragment identification. These transitions and high spin levels of $^{100}$Y have been investigated by analyzing the high statistics $\gamma$-$\gamma$-$\gamma$ and $\gamma$-$\gamma$-$\gamma$-$\gamma$ coincidence data from the spontaneous fission of $^{252}$Cf at the Gammasphere detector array. Two new bands, 14 new levels and 23 new transitions have been identified. The $K^{\pi}=4^+$ new band decaying to an 1s isomeric state is assigned to be the high-$K$ Gallagher-Moszkowski (GM) partner of the known $K^{\pi}=1^+$ band, with the $\pi 5/2[522] \otimes \nu 3/2[411]$ configuration. This 4$^+$ band is also proposed to be the pseudo spin partner of the new $K^{\pi}=5^+$ band with a 5$^{+}$ $\pi 5/2[422] \otimes \nu 5/2[413]$ configuration, to form a $\pi 5/2[422] \otimes \nu [312$ $5/2,3/2]$ neutron pseudospin doublet. Constrained triaxial covariant density functional theory and quantal particle rotor model calculations have been applied to interpret the band structure and available electromagnetic transition probabilities and are found in good agreement with experimental values.

2020年初，新型冠状病毒肺炎（简称新冠肺炎）在湖北省武汉市呈现集中暴发流行。疫情期间，武汉市大多医院被征用为新冠肺炎定点医院，武汉大学人民医院（本部院区）作为武汉市仅有的五家收治急危重症患者的医院之一，承担了大量急危重症患者的诊疗工作。本文阐述了武汉大学人民医院神经外科在新冠肺炎疫情期间，依据该病毒的流行病学特点，结合国家卫生健康委员会发布的新冠肺炎诊疗方案，及时制定了疫情期间神经外科急危重症患者规范化诊疗流程，包括：门急诊管理、住院患者管理、病区的改造与分区以及医护人员的防护等。该流程的制定有效地提高了神经外科急危重症患者的诊疗效率与就医体验，同时最大程度上保障了医护人员的身心健康。.

To solve the problem of grouted spliced sleeve in PC shear wall such as increasing material costs and poor quality, a new type of PC shear wall had been developed whose vertical distributing reinforcement were unconnected. The longitudinal reinforcements in boundary elements were enlarged by Equal-capacity Design Method proposed in this paper to offset the reduction of bearing capacity caused by unconnected vertical distributing reinforcement. To verify the accuracy of the design method and the rationality of the new type shear wall, 10 models had been analysed by finite element method. The results shown that models with unconnected vertical distributing reinforcement had lower bearing capacity, and the contribution of vertical distributing reinforcement to bearing capacity was inversely proportional to axial compression ratio. On this basis, if the longitudinal reinforcements were enlarged by the proposed design method, the capacity of PC models were as well as cast-in-situ ones which proved that the new type of shear wall designed by proposed method was reasonable and available.

Currently, the endemic situation of schistosomiasis has dropped to the lowest level in China; however, there are still factors affecting the transmission of schistosomiasis. Flood disasters may pose a great impact on the transmission of schistosomiasis and even affect the progress of schistosomiasis control and the consolidation of schistosomiasis control achievements. In 2020, major flood disasters occur across China. This paper analyzes the current status of schistosomiasis and the impact of flood disasters on the transmission of schistosomiasis in China, and systematically describes the assessment of and response to schistosomiasis transmission risk before flood disasters, the prevention of

We studied the effects and mechanisms of action of conophylline in different concentrations in the original in vitro model of myocardial fibrosis (treatment of cardiac fibroblasts isolated form the hearts of newborn rats with angiotensin II). Viability, collagen content, and expression of related protein in cardiac fibroblasts were assessed using the MTT-test, Sircol assay, and Western blotting, respectively. Conophylline markedly protected the cultured cells against the development of angiotensin II-induced fibrosis, which was seen from reduced viability of fibroblasts, decreased collagen content, and down-regulation of the expression of α-smooth muscle actin (α-SMA). Conophylline did not affect the TGF-β pathway altered by angiotensin II, but markedly decreased the level of bone morphogenetic protein-4 (BMP4) enhanced by angiotensin II and BMP4 itself. Conophylline produced no effect on phosphorylation of α-SMA and Smad homologue-1/5/8, the classic BMP4 downstream pathway elements, but reduced the level of c-Jun N-terminal kinase (JNK) elevated by BMP4. Conophylline did not inhibit the development of myocardial fibrosis in the presence of JNK activator anisomycin. Thus, conophylline inhibited angiotensin II-provoked myocardial fibrosis via the BMP4/JNK pathway.

BACKGROUND The short-term effect of ambient air pollution on atopic dermatitis (AD), along with its effect modifiers, has not been fully addressed. OBJECTIVES To examine the short-term associations between air pollution and AD, and to identify effect modifications by age and season. METHODS We used the generalized additive model to evaluate the short-term effect of ambient air pollution on daily hospital visits for AD, adjusting for potential confounders. Subgroup analyses were performed to identify potential effect modifications by season and age (< 18 years and ≥ 18 years). RESULTS A total of 29 972 hospital visits for AD were recorded in Guangzhou, China, from 19 January 2013 to 31 December 2017. Among them, 72·8% were visits by children and 51·4% occurred in the cool season. Acute and delayed effects on AD hospital visits were significant for all air pollutants. Stronger effects were seen in the cool season (approximately 1·7-3·0 times higher than effects in the warm season). Stronger effects were also observed in children (approximately 1·3-1·8 times higher than effects in adults). Sensitivity analyses indicated the results were robust. CONCLUSIONS Air pollution might be an important trigger for AD in subtropical Guangzhou, China. Children are more vulnerable than adults, and the effects are stronger in the cool season.

Asbestos is classified as a Class 1 carcinogen by the International Cancer Organization (IARC) , and almost all types of asbestos are carcinogenic. The clinical data of 30 asbestos-induced occupational tumor patients in Qingdao city from January 2002 to May 2019 were analyzed, including 24 cases of asbestos-induced lung cancer and 6 cases of asbestos-induced malignant mesothelioma. Mesothelioma was significantly worse than lung cancer in terms of malignancy, the survival time of patients is shorter, and the mortality rate was higher. Both its diagnostic methods and treatment methods should be improved. The high incidence of asbestos-caused tumors is coming. It is recommended that workers exposed to asbestos dust should undergo regular chest CT examinations for early detection, early diagnosis and early treatment.国际癌症组织（IARC）将石棉列为1类致癌物，几乎所有类型的石棉均有致癌性。本文对收集的青岛市2002年1月至2019年5月诊断的30例石棉所致职业性肿瘤患者临床资料进行分析，其中石棉所致肺癌24例，石棉所致恶性间皮瘤6例。间皮瘤恶性程度高于肺癌，患者生存期短，病死率高，诊断及治疗手段均有待于提高。我国逐步进入石棉所致肿瘤的高发期，建议石棉粉尘暴露的劳动者定期进行胸部CT检查，以期早发现、早诊断、早治疗。.

We studied the mechanisms by which microRNA-126 regulates proliferation and migration of human umbilical vein endothelial cells (HUVEC) cultured in a medium with high glucose concentration and treated with chemokine CXCL8. Cell proliferation, apoptosis, and migration were analyzed by the CCK-8 assay, Annexin V-PI staining, and Transwell assay, respectively. The ratios of p-ERK/ERK, p-P38/P38, p-JNK/JNK were determined by ELISA. HUVEC cells cultured in the presence of high glucose concentration (30 mmol/ml) and treated with CXCL8 (50 ng/ml) demonstrated more intensive proliferation, migration, and p-ERK/ERK, p-P38/P38, and p-JNK/JNK ratios and significantly lower apoptosis rate than control cells (high glucose, no treatment) and cells treated with CXCL8 and transfected with microRNA-126-mimic. Thus, microRNA-126 regulates proliferation and migration of HUVEC cells cultured in the presence of high glucose concentrations and treated with CXCL8 through inhibition of MAPK signaling pathway.

The decay ψ′→π+π−π0 is analyzed using a sample of 14 million ψ′ events taken with the BESII detector at the BEPC, and the branching fraction is measured to be B(ψ′→π+π−π0)=(18.1±1.8±1.9)×10−5. A partial wave analysis is carried out using the helicity amplitude method. ψ′→ρ(770)π is observed, and the branching fraction is measured to be B(ψ′→ρ(770)π)=(5.1±0.7±1.1)×10−5, where the first error is statistical and the second one is systematic. A high mass enhancement with mass around 2.15 GeV/c2 is also observed. Attributing this enhancement to the ρ(2150) resonance, the branching fraction is measured to be B(ψ′→ρ(2150)π→π+π−π0)=(19.4±2.5−3.4+11.5)×10−5. The results will help in the understanding of the longstanding “ρπ puzzle” between J/ψ and ψ′ hadronic decays.

The cross section for the process e(+)e(-)-> pi(+) pi(-) J/psi is measured precisely at center-of-mass energies from 3.77 to 4.60 GeV using 9 fb(-1) of data collected with the BESIII detector operating at the BEPCII storage ring. Two resonant structures are observed in a fit to the cross section. The first resonance has a mass of (222.0 +/- 3.1 +/- 1.4) MeV/ c(2) and a width of (44.1 +/- 4.3 +/- 2.0)MeV, while the second one has a mass of (4320.0 +/- 10.4 +/- 7.0)MeV/c(2) and a width of (101.4(- 19.7)(+25.3) +/- 10.2) MeV, where the first errors are statistical and second ones are systematic. The first resonance agrees with the Y(4260) resonance reported by previous experiments. The precision of its resonant parameters is improved significantly. The second resonance is observed in e(+)e(-)-> pi(+) pi(-) J/psi for the first time. The statistical significance of this resonance is estimated to be larger than 7.6 sigma. The mass and width of the second resonance agree with the Y(4360) resonance reported by the BABAR and Belle experiments within errors. Finally, the Y(4008) resonance previously observed by the Belle experiment is not confirmed in the description of the BESIII data.

To analyze the endemic situation of schistosomiasis in national surveillance sites of Anhui Province from 2015 to 2018, so as to provide scientific evidence for schistosomiasis control and prevention in Anhui Province.According to the National Schistosomiasis Surveillance Programme (2014 version), a total of 51 national schistosomiasis surveillance sites were assigned in Anhui Province in 2015, andA total of 89 638 local residents and 42 609 mobile populations received serological screening of schistosomiasis in 51 national surveillance sites of Anhui Province from 2015 to 2018, and the sero-prevalence ofThe endemic situation of schistosomiasis is at a low level in Anhui Province; however, the risk of schistosomiasis transmission remains in local regions of the province. The construction of the surveillance-responsesystemshouldbereinforcedtoconsolidatetheachievementsofschistosomiasis control in Anhui Province.

To investigate the spatiotemporal distribution ofBased on the snail survey data in Anhui Province in 2016, the distribution of snails and infected snails were analyzed, and the spatial distribution of snails and spatial cluster patterns of infected snails were investigated in snail habitats in Anhui Province from 1950 to 2016.A total of 22 757 snail habitats and 5 004 infected snail habitats were identified in Anhui Province from 1950 to 2016, which appeared single-peak and double-peak patterns, with an inflection point seen in 1970. There were 141 000 hmThe current snail habitats have been present for a long period of time, and snails are difficult to be eliminated by chemical treatment alone, which requires the combination of environment improvements. There are spatial clusters of living snail density in current snail habitats in Anhui Province. The epidemic factors and risk of human and animal infections still remain in some clusters of historical infected snail habitats revealed by spatiotemporal scan analysis, which should be consid- ered as the key target areas for snail control in Anhui Province.

目的 探讨异基因造血干细胞移植（allo-HSCT）治疗合并中枢神经系统白血病（CNSL）患者的疗效。 方法 对2012年5月至2017年12月收治的48例合并CNSL患者进行回顾性分析。 结果 ①全部48例患者中，男38例，女10例，中位年龄20（6~48）岁；急性淋巴细胞白血病（ALL）22例，急性髓系白血病（AML）21例，慢性髓性白血病（CML）5例。移植前骨髓完全缓解（CR）19例（CR组），未缓解（NR）29例（NR组）。②预处理方案：成人采用以全身照射（TBI）为主方案，其中6例患者联合全脑全脊髓放疗，2例患者联合射波刀治疗；儿童患者采用改良伊达比星（IDA）联合Bu-Cy（白消安+环磷酰胺）方案。③48例患者均顺利植活，粒细胞植活中位时间为14（10~23）d，血小板植活的中位时间为16（6~78）d。④移植后28天评估骨髓，48例患者均达CR，经DNA检测证实均为完全供者嵌合状态。⑤中位随访时间为14（2~69）个月，28例患者存活，10例复发，其中CNSL复发3例。移植前CR组、NR组allo-HSCT后1年总生存（OS）率分别为（77.3±10.0）%、（57.6±9.3）%（P=0.409），无病生存率（DFS）分别为（71.2±11.0）%、（53.9±9.5）%（P=0.386）。ALL、AML组移植后1年OS率分别为（54.2±10.7）%、（80.1±8.9）%（P=0.200），DFS率分别为（49.2±10.8）%、（75.0±9.7）%（P=0.190）。 结论 allo-HSCT治疗CNSL是安全、有效的。

This work presents a study on the controlled growth of WO