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1. Amendment of the OMERACT ultrasound definitions of joints’ features in healthy children when using the DOPPLER technique

Author: P. Collado, D. Windschall, J. Vojinovic, S. Magni-Manzoni, P. Balint, G. A. W. Bruyn, C. Hernandez-Diaz, J. C. Nieto, V. Ravagnani, N. Tzaribachev, A. Iagnocco, M. A. D’Agostino, E. Naredo, and on behalf of the OMERACT ultrasound subtask force on pediatric
Subjects: Ultrasonography, Power-Doppler, Pediatric rheumatology, Joint anatomy, Pediatrics, RJ1-570, Diseases of the musculoskeletal system, RC925-935
Abstract: Abstract Background Recently preliminary ultrasonography (US) definitions, in B mode, for normal components of pediatric joints have been developed by the OMERACT US group. The aim of the current study was to include Doppler findings in the evaluation and definition of normal joint features that can be visualized in healthy children at different age groups. Methods A multistep approach was used. Firstly, new additional definitions of joint components were proposed during an expert meeting. In the second step, these definitions, along with the preliminary B-mode-US definitions, were tested for feasibility in an exercise in healthy children at different age groups. In the last step, a larger panel of US experts were invited to join a web-based consensus process in order to approve the developed definitions using the Delphi methodology. A Likert scale of 1–5 was used to assess agreement. Results Physiological vascularity and fat pad tissue were identified and tested as two additional joint components in healthy children. Since physiological vascularity changes over the time in the growing skeleton, the final definition of Doppler findings comprised separate statements instead of a single full definition. A total of seven statements was developed and included in a written Delphi questionnaire to define and validate the new components. The final definitions for fat pad and physiological vascularity agreed by the group of experts reached 92.9% and 100% agreement respectively in a web survey. Conclusion The inclusion of these two additional joints components which are linked to detection of Doppler signal in pediatric healthy joints will improve the identification of abnormalities in children with joint pathologies.
Published: 2018
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2. Bernudagrass adaptation in the mediterranean climate: phenotypic traits of 44 accessions

Author: S. Magni, Monica Gaetani, N. Grossi, L. Caturegli, S. La Bella, C. Leto, G. Virga, T. Tuttolomondo, F. Lulli, and M. Volterrani
Subjects: colour, Cynodon dactylon, green-up, node density, quality, Biology (General), QH301-705.5, Botany, QK1-989
Abstract: The use of bermudagrass in the Mediterranean area is increasing for its outstanding tolerance to heat and drought, and its aggressive growth and high recuperative potential make it particularly suited to heavily worn areas and appreciated for sports turfs. However, the overall performance of a given genetic type can be affected by the adaptation to a specific environment. The objective of this research was to determine the variability of a number of phenotypic traits that can affect bermudagrass turf performance on a wide range of bermudagrass accessions grown in two locations in Italy. In May 2010, 44 accessions of bermudagrasses, grouped in “wild”, “improved” “hybrid” and “dwarf” types were transplanted in the center of field plots in Pisa and Palermo. In 2011, when the turf was completely established, the following traits were determined: shoot density, horizontal stem density, node density, leaf width, colour, quality, spring green-up, and fall colour retention. Dwarf and hybrid types yielded the best aesthetic characteristics. With respect to colour retention and spring green-up, great variability was recorded within the groups. Dwarf types presented the earliest dormancy, while the hybrid types were in general the ones to green-up first in spring.
Published: 2014
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3. Health Equity Implications of Missing Data Among Youths With Childhood‐Onset Systemic Lupus Erythematosus: A Proof‐of‐Concept Study in the Childhood Arthritis and Rheumatology Research Alliance Registry

Author: Woo, Jennifer M. P., Simmonds, Faith, Dennos, Anne, Son, Mary Beth F., Lewandowski, Laura B., Rubinstein, Tamar B., Abel, N., Abulaban, K., Adams, A., Adams, M., Agbayani, R., Aiello, J., Akoghlanian, S., Alejandro, C., Allenspach, E., Alperin, R., Alpizar, M., Amarilyo, G., Ambler, W., Anderson, E., Ardoin, S., Armendariz, S., Baker, E., Balboni, I., Balevic, S., Ballenger, L., Ballinger, S., Balmuri, N., Barbar‐Smiley, F., Barillas‐Arias, L., Basiaga, M., Baszis, K., Becker, M., Bell‐Brunson, H., Beltz, E., Benham, H., Benseler, S., Bernal, W., Beukelman, T., Bigley, T., Binstadt, B., Black, C., Blakley, M., Bohnsack, J., Boland, J., Boneparth, A., Bowman, S., Bracaglia, C., Brooks, E., Brothers, M., Brown, A., Brunner, H., Buckley, M., Buckley, M., Bukulmez, H., Bullock, D., Cameron, B., Canna, S., Cannon, L., Carper, P., Cartwright, V., Cassidy, E., Cerracchio, L., Chalom, E., Chang, J., Chang‐Hoftman, A., Chauhan, V., Chira, P., Chinn, T., Chundru, K., Clairman, H., Co, D., Confair, A., Conlon, H., Connor, R., Cooper, A., Cooper, J., Cooper, S., Correll, C., Corvalan, R., Costanzo, D., Cron, R., Curiel‐Duran, L., Curington, T., Curry, M., Dalrymple, A., Davis, A., Davis, C., Davis, C., Davis, T., De Benedetti, F., De Ranieri, D., Dean, J., Dedeoglu, F., DeGuzman, M., Delnay, N., Dempsey, V., DeSantis, E., Dickson, T., Dingle, J., Donaldson, B., Dorsey, E., Dover, S., Dowling, J., Drew, J., Driest, K., Du, Q., Duarte, K., Durkee, D., Duverger, E., Dvergsten, J., Eberhard, A., Eckert, M., Ede, K., Edelheit, B., Edens, C., Edens, C., Edgerly, Y., Elder, M., Ervin, B., Fadrhonc, S., Failing, C., Fair, D., Falcon, M., Favier, L., Federici, S., Feldman, B., Fennell, J., Ferguson, I., Ferguson, P., Ferreira, B., Ferrucho, R., Fields, K., Finkel, T., Fitzgerald, M., Fleming, C., Flynn, O., Fogel, L., Fox, E., Fox, M., Franco, L., Freeman, M., Fritz, K., Froese, S., Fuhlbrigge, R., Fuller, J., George, N., Gerhold, K., Gerstbacher, D., Gilbert, M., Gillispie‐Taylor, M., Giverc, E., Godiwala, C., Goh, I., Goheer, H., Goldsmith, D., Gotschlich, E., Gotte, A., Gottlieb, B., Gracia, C., Graham, T., Grevich, S., Griffin, T., Griswold, J., Grom, A., Guevara, M., Guittar, P., Guzman, M., Hager, M., Hahn, T., Halyabar, O., Hammelev, E., Hance, M., Hanson, A., Harel, L., Haro, S., Harris, J., Harry, O., Hartigan, E., Hausmann, J., Hay, A., Hayward, K., Heiart, J., Hekl, K., Henderson, L., Henrickson, M., Hersh, A., Hickey, K., Hill, P., Hillyer, S., Hiraki, L., Hiskey, M., Hobday, P., Hoffart, C., Holland, M., Hollander, M., Hong, S., Horwitz, M., Hsu, J., Huber, A., Huggins, J., Hui‐Yuen, J., Hung, C., Huntington, J., Huttenlocher, A., Ibarra, M., Imundo, L., Inman, C., Insalaco, A., Jackson, A., Jackson, S., James, K., Janow, G., Jaquith, J., Jared, S., Johnson, N., Jones, J., Jones, J., Jones, J., Jones, K., Jones, S., Joshi, S., Jung, L., Justice, C., Justiniano, A., Karan, N., Kaufman, K., Kemp, A., Kessler, E., Khalsa, U., Kienzle, B., Kim, S., Kimura, Y., Kingsbury, D., Kitcharoensakkul, M., Klausmeier, T., Klein, K., Klein‐Gitelman, M., Kompelien, B., Kosikowski, A., Kovalick, L., Kracker, J., Kramer, S., Kremer, C., Lai, J., Lam, J., Lang, B., Lapidus, S., Lapin, B., Lasky, A., Latham, D., Lawson, E., Laxer, R., Lee, P., Lee, P., Lee, T., Lentini, L., Lerman, M., Levy, D., Li, S., Lieberman, S., Lim, L., Lin, C., Ling, N., Lingis, M., Lo, M., Lovell, D., Lowman, D., Luca, N., Lvovich, S., Madison, C., Madison, J., Manzoni, S. Magni, Malla, B., Maller, J., Malloy, M., Mannion, M., Manos, C., Marques, L., Martyniuk, A., Mason, T., Mathus, S., McAllister, L., McCarthy, K., McConnell, K., McCormick, E., McCurdy, D., Stokes, P. McCurdy, McGuire, S., McHale, I., McMonagle, A., McMullen‐Jackson, C., Meidan, E., Mellins, E., Mendoza, E., Mercado, R., Merritt, A., Michalowski, L., Miettunen, P., Miller, M., Milojevic, D., Mirizio, E., Misajon, E., Mitchell, M., Modica, R., Mohan, S., Moore, K., Moorthy, L., Morgan, S., Dewitt, E. Morgan, Moss, C., Moussa, T., Mruk, V., Murphy, A., Muscal, E., Nadler, R., Nahal, B., Nanda, K., Nasah, N., Nassi, L., Nativ, S., Natter, M., Neely, J., Nelson, B., Newhall, L., Ng, L., Nicholas, J., Nicolai, R., Nigrovic, P., Nocton, J., Nolan, B., Oberle, E., Obispo, B., OʼBrien, B., OʼBrien, T., Okeke, O., Oliver, M., Olson, J., OʼNeil, K., Onel, K., Orandi, A., Orlando, M., Osei‐Onomah, S., Oz, R., Pagano, E., Paller, A., Pan, N., Panupattanapong, S., Pardeo, M., Paredes, J., Parsons, A., Patel, J., Pentakota, K., Pepmueller, P., Pfeiffer, T., Phillippi, K., Phillippi, K., Marafon, D. Pires, Ponder, L., Pooni, R., Prahalad, S., Pratt, S., Protopapas, S., Puplava, B., Quach, J., Quinlan‐Waters, M., Rabinovich, C., Radhakrishna, S., Rafko, J., Raisian, J., Rakestraw, A., Ramirez, C., Ramsay, E., Ramsey, S., Randell, R., Reed, A., Reed, A., Reed, A., Reid, H., Remmel, K., Repp, A., Reyes, A., Richmond, A., Riebschleger, M., Ringold, S., Riordan, M., Riskalla, M., Ritter, M., Rivas‐Chacon, R., Robinson, A., Rodela, E., Rodriquez, M., Rojas, K., Ronis, T., Rosenkranz, M., Rosolowski, B., Rothermel, H., Rothman, D., Roth‐Wojcicki, E., Rouster‐Stevens, K., Rubinstein, T., Ruth, N., Saad, N., Sabbagh, S., Sacco, E., Sadun, R., Sandborg, C., Sanni, A., Santiago, L., Sarkissian, A., Savani, S., Scalzi, L., Schanberg, L., Scharnhorst, S., Schikler, K., Schlefman, A., Schmeling, H., Schmidt, K., Schmitt, E., Schneider, R., Schollaert‐Fitch, K., Schulert, G., Seay, T., Seper, C., Shalen, J., Sheets, R., Shelly, A., Shenoi, S., Shergill, K., Shirley, J., Shishov, M., Shivers, C., Silverman, E., Singer, N., Sivaraman, V., Sletten, J., Smith, A., Smith, C., Smith, J., Smith, J., Smitherman, E., Soep, J., Son, M., Spence, S., Spiegel, L., Spitznagle, J., Sran, R., Srinivasalu, H., Stapp, H., Steigerwald, K., Rakovchik, Y. Sterba, Stern, S., Stevens, A., Stevens, B., Stevenson, R., Stewart, K., Stingl, C., Stokes, J., Stoll, M., Stringer, E., Sule, S., Sumner, J., Sundel, R., Sutter, M., Syed, R., Syverson, G., Szymanski, A., Taber, S., Tal, R., Tambralli, A., Taneja, A., Tanner, T., Tapani, S., Tarshish, G., Tarvin, S., Tate, L., Taxter, A., Taylor, J., Terry, M., Tesher, M., Thatayatikom, A., Thomas, B., Tiffany, K., Ting, T., Tipp, A., Toib, D., Torok, K., Toruner, C., Tory, H., Toth, M., Tse, S., Tubwell, V., Twilt, M., Uriguen, S., Valcarcel, T., Van Mater, H., Vannoy, L., Varghese, C., Vasquez, N., Vazzana, K., Vehe, R., Veiga, K., Velez, J., Verbsky, J., Vilar, G., Volpe, N., von Scheven, E., Vora, S., Wagner, J., Wagner‐Weiner, L., Wahezi, D., Waite, H., Walker, J., Walters, H., Muskardin, T. Wampler, Waqar, L., Waterfield, M., Watson, M., Watts, A., Weiser, P., Weiss, J., Weiss, P., Wershba, E., White, A., Williams, C., Wise, A., Woo, J., Woolnough, L., Wright, T., Wu, E., Yalcindag, A., Yee, M., Yen, E., Yeung, R., Yomogida, K., Yu, Q., Zapata, R., Zartoshti, A., Zeft, A., Zeft, R., Zhang, Y., Zhao, Y., Zhu, A., and Zic, C.
Published: 2023
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4. Childhood‐Onset Lupus Nephritis in the Childhood Arthritis and Rheumatology Research Alliance Registry: Short‐Term Kidney Status and Variation in Care

Author: Smitherman, Emily A., Chahine, Rouba A., Beukelman, Timothy, Lewandowski, Laura B., Rahman, A. K. M. Fazlur, Wenderfer, Scott E., Curtis, Jeffrey R., Hersh, Aimee O., Abel, N., Abulaban, K., Adams, A., Adams, M., Agbayani, R., Aiello, J., Akoghlanian, S., Alejandro, C., Allenspach, E., Alperin, R., Alpizar, M., Amarilyo, G., Ambler, W., Anderson, E., Ardoin, S., Armendariz, S., Baker, E., Balboni, I., Balevic, S., Ballenger, L., Ballinger, S., Balmuri, N., Barbar‐Smiley, F., Barillas‐Arias, L., Basiaga, M., Baszis, K., Becker, M., Bell‐Brunson, H., Beltz, E., Benham, H., Benseler, S., Bernal, W., Beukelman, T., Bigley, T., Binstadt, B., Black, C., Blakley, M., Bohnsack, J., Boland, J., Boneparth, A., Bowman, S., Bracaglia, C., Brooks, E., Brothers, M., Brown, A., Brunner, H., Buckley, M., Buckley, M., Bukulmez, H., Bullock, D., Cameron, B., Canna, S., Cannon, L., Carper, P., Cartwright, V., Cassidy, E., Cerracchio, L., Chalom, E., Chang, J., Chang‐Hoftman, A., Chauhan, V., Chira, P., Chinn, T., Chundru, K., Clairman, H., Co, D., Confair, A., Conlon, H., Connor, R., Cooper, A., Cooper, J., Cooper, S., Correll, C., Corvalan, R., Costanzo, D., Cron, R., Curiel‐Duran, L., Curington, T., Curry, M., Dalrymple, A., Davis, A., Davis, C., Davis, C., Davis, T., De Benedetti, F., De Ranieri, D., Dean, J., Dedeoglu, F., DeGuzman, M., Delnay, N., Dempsey, V., DeSantis, E., Dickson, T., Dingle, J., Donaldson, B., Dorsey, E., Dover, S., Dowling, J., Drew, J., Driest, K., Du, Q., Duarte, K., Durkee, D., Duverger, E., Dvergsten, J., Eberhard, A., Eckert, M., Ede, K., Edelheit, B., Edens, C., Edens, C., Edgerly, Y., Elder, M., Ervin, B., Fadrhonc, S., Failing, C., Fair, D., Falcon, M., Favier, L., Federici, S., Feldman, B., Fennell, J., Ferguson, I., Ferguson, P., Ferreira, B., Ferrucho, R., Fields, K., Finkel, T., Fitzgerald, M., Fleming, C., Flynn, O., Fogel, L., Fox, E., Fox, M., Franco, L., Freeman, M., Fritz, K., Froese, S., Fuhlbrigge, R., Fuller, J., George, N., Gerhold, K., Gerstbacher, D., Gilbert, M., Gillispie‐Taylor, M., Giverc, E., Godiwala, C., Goh, I., Goheer, H., Goldsmith, D., Gotschlich, E., Gotte, A., Gottlieb, B., Gracia, C., Graham, T., Grevich, S., Griffin, T., Griswold, J., Grom, A., Guevara, M., Guittar, P., Guzman, M., Hager, M., Hahn, T., Halyabar, O., Hammelev, E., Hance, M., Hanson, A., Harel, L., Haro, S., Harris, J., Harry, O., Hartigan, E., Hausmann, J., Hay, A., Hayward, K., Heiart, J., Hekl, K., Henderson, L., Henrickson, M., Hersh, A., Hickey, K., Hill, P., Hillyer, S., Hiraki, L., Hiskey, M., Hobday, P., Hoffart, C., Holland, M., Hollander, M., Hong, S., Horwitz, M., Hsu, J., Huber, A., Huggins, J., Hui‐Yuen, J., Hung, C., Huntington, J., Huttenlocher, A., Ibarra, M., Imundo, L., Inman, C., Insalaco, A., Jackson, A., Jackson, S., James, K., Janow, G., Jaquith, J., Jared, S., Johnson, N., Jones, J., Jones, J., Jones, J., Jones, K., Jones, S., Joshi, S., Jung, L., Justice, C., Justiniano, A., Karan, N., Kaufman, K., Kemp, A., Kessler, E., Khalsa, U., Kienzle, B., Kim, S., Kimura, Y., Kingsbury, D., Kitcharoensakkul, M., Klausmeier, T., Klein, K., Klein‐Gitelman, M., Kompelien, B., Kosikowski, A., Kovalick, L., Kracker, J., Kramer, S., Kremer, C., Lai, J., Lam, J., Lang, B., Lapidus, S., Lapin, B., Lasky, A., Latham, D., Lawson, E., Laxer, R., Lee, P., Lee, P., Lee, T., Lentini, L., Lerman, M., Levy, D., Li, S., Lieberman, S., Lim, L., Lin, C., Ling, N., Lingis, M., Lo, M., Lovell, D., Lowman, D., Luca, N., Lvovich, S., Madison, C., Madison, J., Manzoni, S. Magni, Malla, B., Maller, J., Malloy, M., Mannion, M., Manos, C., Marques, L., Martyniuk, A., Mason, T., Mathus, S., McAllister, L., McCarthy, K., McConnell, K., McCormick, E., McCurdy, D., Stokes, P. McCurdy, McGuire, S., McHale, I., McMonagle, A., McMullen‐Jackson, C., Meidan, E., Mellins, E., Mendoza, E., Mercado, R., Merritt, A., Michalowski, L., Miettunen, P., Miller, M., Milojevic, D., Mirizio, E., Misajon, E., Mitchell, M., Modica, R., Mohan, S., Moore, K., Moorthy, L., Morgan, S., Dewitt, E. Morgan, Moss, C., Moussa, T., Mruk, V., Murphy, A., Muscal, E., Nadler, R., Nahal, B., Nanda, K., Nasah, N., Nassi, L., Nativ, S., Natter, M., Neely, J., Nelson, B., Newhall, L., Ng, L., Nicholas, J., Nicolai, R., Nigrovic, P., Nocton, J., Nolan, B., Oberle, E., Obispo, B., OʼBrien, B., OʼBrien, T., Okeke, O., Oliver, M., Olson, J., OʼNeil, K., Onel, K., Orandi, A., Orlando, M., Osei‐Onomah, S., Oz, R., Pagano, E., Paller, A., Pan, N., Panupattanapong, S., Pardeo, M., Paredes, J., Parsons, A., Patel, J., Pentakota, K., Pepmueller, P., Pfeiffer, T., Phillippi, K., Marafon, D. Pires, Phillippi, K., Ponder, L., Pooni, R., Prahalad, S., Pratt, S., Protopapas, S., Puplava, B., Quach, J., Quinlan‐Waters, M., Rabinovich, C., Radhakrishna, S., Rafko, J., Raisian, J., Rakestraw, A., Ramirez, C., Ramsay, E., Ramsey, S., Randell, R., Reed, A., Reed, A., Reed, A., Reid, H., Remmel, K., Repp, A., Reyes, A., Richmond, A., Riebschleger, M., Ringold, S., Riordan, M., Riskalla, M., Ritter, M., Rivas‐Chacon, R., Robinson, A., Rodela, E., Rodriquez, M., Rojas, K., Ronis, T., Rosenkranz, M., Rosolowski, B., Rothermel, H., Rothman, D., Roth‐Wojcicki, E., Rouster – Stevens, K., Rubinstein, T., Ruth, N., Saad, N., Sabbagh, S., Sacco, E., Sadun, R., Sandborg, C., Sanni, A., Santiago, L., Sarkissian, A., Savani, S., Scalzi, L., Schanberg, L., Scharnhorst, S., Schikler, K., Schlefman, A., Schmeling, H., Schmidt, K., Schmitt, E., Schneider, R., Schollaert‐Fitch, K., Schulert, G., Seay, T., Seper, C., Shalen, J., Sheets, R., Shelly, A., Shenoi, S., Shergill, K., Shirley, J., Shishov, M., Shivers, C., Silverman, E., Singer, N., Sivaraman, V., Sletten, J., Smith, A., Smith, C., Smith, J., Smith, J., Smitherman, E., Soep, J., Son, M., Spence, S., Spiegel, L., Spitznagle, J., Sran, R., Srinivasalu, H., Stapp, H., Steigerwald, K., Rakovchik, Y. Sterba, Stern, S., Stevens, A., Stevens, B., Stevenson, R., Stewart, K., Stingl, C., Stokes, J., Stoll, M., Stringer, E., Sule, S., Sumner, J., Sundel, R., Sutter, M., Syed, R., Syverson, G., Szymanski, A., Taber, S., Tal, R., Tambralli, A., Taneja, A., Tanner, T., Tapani, S., Tarshish, G., Tarvin, S., Tate, L., Taxter, A., Taylor, J., Terry, M., Tesher, M., Thatayatikom, A., Thomas, B., Tiffany, K., Ting, T., Tipp, A., Toib, D., Torok, K., Toruner, C., Tory, H., Toth, M., Tse, S., Tubwell, V., Twilt, M., Uriguen, S., Valcarcel, T., Van Mater, H., Vannoy, L., Varghese, C., Vasquez, N., Vazzana, K., Vehe, R., Veiga, K., Velez, J., Verbsky, J., Vilar, G., Volpe, N., von Scheven, E., Vora, S., Wagner, J., Wagner‐Weiner, L., Wahezi, D., Waite, H., Walker, J., Walters, H., Muskardin, T. Wampler, Waqar, L., Waterfield, M., Watson, M., Watts, A., Weiser, P., Weiss, J., Weiss, P., Wershba, E., White, A., Williams, C., Wise, A., Woo, J., Woolnough, L., Wright, T., Wu, E., Yalcindag, A., Yee, M., Yen, E., Yeung, R., Yomogida, K., Yu, Q., Zapata, R., Zartoshti, A., Zeft, A., Zeft, R., Zhang, Y., Zhao, Y., Zhu, A., and Zic, C.
Published: 2023
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5. Pharmacokinetics of hydroxychloroquine in paediatric lupus: data from a novel, direct-to-family clinical trial

Author: E Schmitt, C Smith, G Schulert, S Canna, A Grom, E Mellins, A Brown, J Smith, A Stevens, M Watson, S Jones, K Stewart, E Baker, A Kemp, T Davis, A Smith, S Jackson, C Williams, K Jones, T Mason, A Hanson, Y Zhao, B Thomas, A Reed, J Jones, J Cooper, T Lee, J Chang, M Holland, S Joshi, L Lim, C Ramírez, A Murphy, K Moore, E Pagano, B ferreira, S Li, P Lee, H Schmeling, K Abulaban, R Agbayani, S Akoghlanian, E Anderson, L Barillas-Arias, K Baszis, M Becker, H Bell-Brunson, H Benham, S Benseler, T Beukelman, H Brunner, H Bukulmez, L Cerracchio, E Chalom, K Chundru, J Dean, F Dedeoglu, V Dempsey, J Drew, B Feldman, P Ferguson, C Fleming, L Franco, I Goh, D Goldsmith, B Gottlieb, T Graham, T Griffin, M Hance, K Hickey, M Hollander, J Hsu, A Huber, C Hung, A Huttenlocher, L Imundo, C Inman, J Jaquith, L Jung, D Kingsbury, K Klein, M Klein-Gitelman, S Kramer, S Lapidus, D Latham, B Malla, M Malloy, A Martyniuk, K McConnell, D McCurdy, C McMullen-Jackson, L Moorthy, E Muscal, J Olson, K Onel, L Ponder, S Prahalad, C Rabinovich, S Ringold, M Riordan, A Robinson, M Rosenkranz, B Rosolowski, N Ruth, K Schikler, H Stapp, R Syed, M Tesher, A Thatayatikom, R Vehe, E von Scheven, D Wahezi, A Watts, J Weiss, J Wagner, S Kim, Y Zhang, L Favier, J Patel, S Morgan, A Jackson, J Stokes, L Marques, Stephen J Balevic, K Hayward, A White, J Nicholas, D Lovell, A Zeft, J Harris, E Lawson, C Moss, N George, M Sutter, A Cooper, M Adams, S Cooper, M Miller, C Black, R Schneider, J Taylor, R Sran, M Oliver, M Twilt, M Tóth, J Walker, M Mitchell, F De Benedetti, N Singer, M Fox, K Kaufman, A Merritt, R Stevenson, J Fuller, M Fitzgerald, A Davis, C Davis, L Henderson, J Woo, S Mohan, H Reid, Y Kimura, L Harel, R Laxer, K McCarthy, I Ferguson, E McCormick, A Hay, M Guzman, E Fox, P Hill, A PARSONS, S McGuire, J Lam, C Sandborg, B Stevens, J Boland, S Ballinger, E MENDOZA, J NOCTON, M Ritter, N Johnson, J Shirley, S Bowman, M Ibarra, S Hong, M Guevara, K James, L Santiago, A Adams, B DONALDSON, M Son, C Kremer, K Schmidt, T Wright, L Cannon, R Nicolai, M Freeman, S Spence, D Levy, J Paredes, K Gerhold, A Insalaco, T O'Brien, W Bernal, E Kessler, C Lin, M Lerman, T Hahn, B O'Brien, Michael Cohen-Wolkowiez, Christoph P Hornik, N Abel, J Aiello, C Alejandro, E Allenspach, R Alperin, M Alpizar, G Amarilyo, W Ambler, S Ardoin, S Armendariz, I Balboni, S Balevic, L Ballenger, N Balmuri, F Barbar-Smiley, M Basiaga, E Beltz, T Bigley, B Binstadt, M Blakley, J Bohnsack, A Boneparth, C Bracaglia, E Brooks, M Brothers, M Buckley, D Bullock, B Cameron, P Carper, V Cartwright, E Cassidy, A Chang-Hoftman, V Chauhan, P Chira, T Chinn, H Clairman, D Co, A Confair, H Conlon, R Connor, C Correll, R Corvalan, D Costanzo, R Cron, L Curiel-Duran, T Curington, M Curry, A Dalrymple, D De Ranieri, M De Guzman, N Delnay, E DeSantis, T Dickson, J Dingle, E Dorsey, S Dover, J Dowling, K Driest, Q Du, K Duarte, D Durkee, E Duverger, J Dvergsten, A Eberhard, M Eckert, K Ede, B Edelheit, C Edens, Y Edgerly, M Elder, B Ervin, S Fadrhonc, C Failing, D Fair, M Falcon, S Federici, J Fennell, R Ferrucho, K Fields, T Finkel, O Flynn, L Fogel, K Fritz, S Froese, R Fuhlbrigge, D Gerstbacher, M Gilbert, M Gillispie-Taylor, E Giverc, C Godiwala, H Goheer, E Gotschlich, A Gotte, C Gracia, S Grevich, J Griswold, P Guittar, M Hager, O Halyabar, E Hammelev, S Haro, O Harry, E Hartigan, J Hausmann, J Heiart, K Hekl, M Henrickson, A Hersh, S Hillyer, L Hiraki, M Hiskey, P Hobday, C Hoffart, M Horwitz, J Huggins, J HuiYuen, J Huntington, G Janow, S Jared, C Justice, A Justiniano, N Karan, U Khalsa, B Kienzle, M Kitcharoensakkul, T Klausmeier, B Kompelien, A Kosikowski, L Kovalick, J Kracker, J Lai, B Lang, B Lapin, A Lasky, L Lentini, S Lieberman, N Ling, M Lingis, M Lo, D Lowman, N Luca, S Lvovich, C Madison, J Madison, S Magni Manzoni, J Maller, M Mannion, C Manos, S Mathus, L McAllister, P McCurdy Stokes, I McHale, A McMonagle, E Meidan, R Mercado, L Michalowski, P Miettunen, D Milojevic, E Mirizio, E Misajon, R Modica, E Morgan Dewitt, T Moussa, V Mruk, R Nadler, B Nahal, K Nanda, N Nasah, L Nassi, S Nativ, M Natter, J Neely, B Nelson, L Newhall, L Ng, P Nigrovic, B Nolan, E Oberle, B Obispo, O Okeke, K O'Neil, A Orandi, M Orlando, S Osei-Onomah, R Oz, A Paller, N Pan, S Panupattanapong, M Pardeo, K Pentakota, P Pepmueller, T Pfeiffer, K Phillippi, D Pires Marafon, R Pooni, S Pratt, S Protopapas, B Puplava, J Quach, M Quinlan-Waters, S Radhakrishna, J Rafko, J Raisian, A Rakestraw, E Ramsay, S Ramsey, R Randell, K Remmel, A Repp, A Reyes, A Richmond, M Riebschleger, M Riskalla, R Rivas-Chacon, E Rodela, M Rodriquez, K Rojas, T Ronis, H Rothermel, D Rothman, E Roth-Wojcicki, K Rouster-Stevens, T Rubinstein, N Saad, S Sabbagh, E Sacco, R Sadun, A Sanni, A Sarkissian, S Savani, L Scalzi, L Schanberg, S Scharnhorst, A Schlefman, K Schollaert-Fitch, T Seay, C Seper, J Shalen, R Sheets, A Shelly, S Shenoi, K Shergill, M Shishov, C Shivers, E Silverman, V Sivaraman, J Sletten, E Smitherman, J Soep, L Spiegel, J Spitznagle, H Srinivasalu, K Steigerwald, Y Sterba Rakovchik, S Stern, C Stingl, M Stoll, E Stringer, S Sule, J Sumner, R Sundel, G Syverson, A Szymanski, S Taber, R Tal, A Tambralli, A Taneja, T Tanner, S Tapani, G Tarshish, S Tarvin, L Tate, A Taxter, M Terry, K Tiffany, T Ting, A Tipp, D Toib, K Torok, C Toruner, H Tory, S Tse, V Tubwell, S Uriguen, T Valcarcel, H Van Mater, L Vannoy, C Varghese, N Vasquez, K Vazzana, K Veiga, J Velez, J Verbsky, G Vilar, N Volpe, S Vora, L Wagner-Weiner, H Waite, H Walters, T Wampler Muskardin, L Waqar, M Waterfield, P Weiser, P Weiss, E Wershba, A Wise, L Woolnough, E Wu, A Yalcindag, M Yee, E Yen, R Yeung, K Yomogida, Q Yu, R Zapata, A Zartoshti, R Zeft, A Zhu, C Zic, Daniel Weiner, Daniel Gonzalez, Rachel Randell, and Claire Beard
Subjects: Immunologic diseases. Allergy, RC581-607
Abstract: Objective Determine the pharmacokinetics (PK) and exposure–response of hydroxychloroquine (HCQ) and desethylhydroxychloroquine (DHCQ) in paediatric SLE (pSLE).Methods We conducted an exploratory phase 2, direct-to-family trial. Children enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry with a diagnosis of pSLE were eligible if they were receiving HCQ as standard of care for ≥3 months. Biological samples were collected at up to four visits over a 6-month period. At each visit, plasma was obtained to measure the concentrations of HCQ and DHCQ, as well as cytokines. HCQ and DHCQ plasma PK data were analysed using a population PK modelling approach.Results Twenty-five subjects provided a total of 88 plasma concentrations for PK analysis. There was a poor linear fit between HCQ concentrations and total body weight (R2=0.03). There was a decline in both interferon (IFN)-alpha and IFN-gamma with higher concentrations of HCQ and DHCQ. Volume of distribution for HCQ in plasma was higher in children compared with published values in adults (73 000 L vs 44 000 L), but clearance values in children were similar to adults.Conclusions We report the first population PK model for HCQ and DHCQ in children using data from a novel direct-to-family clinical trial. We observed high interindividual variability in HCQ PK and found that weight-based dosing for HCQ is poorly correlated with drug concentrations, suggesting the need to use therapeutic drug monitoring to individualise dosing. Furthermore, our results suggest that the current weight-based dosing paradigm for HCQ may result in suboptimal drug exposures, particularly for children with obesity. Accordingly, additional studies of HCQ are needed in pSLE to determine the optimal drug concentration and dosing to reduce disease activity and improve outcomes.Trial registration number NCT04358302.
Published: 2022
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6. Delivering clinical trials at home: protocol, design and implementation of a direct-to-family paediatric lupus trial

Author: Laura E Schanberg, S Canna, A Grom, E Mellins, A Brown, S Jones, E Baker, A Kemp, T Davis, S Jackson, K Jones, T Mason, A Hanson, J Jones, J Cooper, T Lee, J Chang, M Holland, S Joshi, L Lim, A Murphy, K Moore, B ferreira, S Li, P Lee, K Abulaban, R Agbayani, S Akoghlanian, E Anderson, L Barillas-Arias, K Baszis, M Becker, H Bell-Brunson, H Benham, S Benseler, T Beukelman, H Brunner, H Bukulmez, L Cerracchio, E Chalom, K Chundru, J Dean, F Dedeoglu, V Dempsey, J Drew, B Feldman, P Ferguson, C Fleming, L Franco, I Goh, D Goldsmith, B Gottlieb, T Graham, T Griffin, M Hance, K Hickey, M Hollander, J Hsu, A Huber, C Hung, A Huttenlocher, L Imundo, C Inman, J Jaquith, L Jung, D Kingsbury, K Klein, M Klein-Gitelman, S Kramer, S Lapidus, D Latham, B Malla, M Malloy, A Martyniuk, K McConnell, D McCurdy, C McMullen-Jackson, L Moorthy, E Muscal, S Kim, L Favier, S Morgan, A Jackson, L Marques, Stephen J Balevic, K Hayward, J Nicholas, D Lovell, J Harris, E Lawson, C Moss, N George, A Cooper, Rachel L Randell, M Adams, S Cooper, M Miller, C Black, M Mitchell, F De Benedetti, M Fox, K Kaufman, A Merritt, J Fuller, M Fitzgerald, A Davis, C Davis, L Henderson, S Mohan, Y Kimura, L Harel, R Laxer, K McCarthy, I Ferguson, E McCormick, A Hay, M Guzman, E Fox, P Hill, S McGuire, J Lam, J Boland, S Ballinger, E MENDOZA, J NOCTON, N Johnson, S Bowman, M Ibarra, S Hong, M Guevara, K James, A Adams, B DONALDSON, C Kremer, L Cannon, R Nicolai, M Freeman, D Levy, K Gerhold, A Insalaco, W Bernal, E Kessler, C Lin, M Lerman, T Hahn, Lindsay Singler, Anthony Cunningham, Michael Cohen-Wolkowiez, Christoph P Hornik, N Abel, J Aiello, C Alejandro, E Allenspach, R Alperin, M Alpizar, G Amarilyo, W Ambler, S Ardoin, S Armendariz, I Balboni, S Balevic, L Ballenger, N Balmuri, F Barbar-Smiley, M Basiaga, E Beltz, T Bigley, B Binstadt, M Blakley, J Bohnsack, A Boneparth, C Bracaglia, E Brooks, M Brothers, M Buckley, D Bullock, B Cameron, P Carper, V Cartwright, E Cassidy, A Chang-Hoftman, V Chauhan, P Chira, T Chinn, H Clairman, D Co, A Confair, H Conlon, R Connor, C Correll, R Corvalan, D Costanzo, R Cron, L Curiel-Duran, T Curington, M Curry, A Dalrymple, D De Ranieri, M De Guzman, N Delnay, E DeSantis, T Dickson, J Dingle, E Dorsey, S Dover, J Dowling, K Driest, Q Du, K Duarte, D Durkee, E Duverger, J Dvergsten, A Eberhard, M Eckert, K Ede, B Edelheit, C Edens, Y Edgerly, M Elder, B Ervin, S Fadrhonc, C Failing, D Fair, M Falcon, S Federici, J Fennell, R Ferrucho, K Fields, T Finkel, O Flynn, L Fogel, K Fritz, S Froese, R Fuhlbrigge, D Gerstbacher, M Gilbert, M Gillispie-Taylor, E Giverc, C Godiwala, H Goheer, E Gotschlich, A Gotte, C Gracia, S Grevich, J Griswold, P Guittar, M Hager, O Halyabar, E Hammelev, S Haro, O Harry, E Hartigan, J Hausmann, J Heiart, K Hekl, M Henrickson, A Hersh, S Hillyer, L Hiraki, M Hiskey, P Hobday, C Hoffart, M Horwitz, J Huggins, J HuiYuen, J Huntington, G Janow, S Jared, C Justice, A Justiniano, N Karan, U Khalsa, B Kienzle, M Kitcharoensakkul, T Klausmeier, B Kompelien, A Kosikowski, L Kovalick, J Kracker, J Lai, B Lang, B Lapin, A Lasky, L Lentini, S Lieberman, N Ling, M Lingis, M Lo, D Lowman, N Luca, S Lvovich, C Madison, J Madison, S Magni Manzoni, J Maller, M Mannion, C Manos, S Mathus, L McAllister, P McCurdy Stokes, I McHale, A McMonagle, E Meidan, R Mercado, L Michalowski, P Miettunen, D Milojevic, E Mirizio, E Misajon, R Modica, E Morgan Dewitt, T Moussa, V Mruk, R Nadler, B Nahal, K Nanda, N Nasah, L Nassi, S Nativ, M Natter, J Neely, B Nelson, L Newhall, L Ng, P Nigrovic, B Nolan, E Oberle, and B Obispo
Subjects: Immunologic diseases. Allergy, RC581-607
Abstract: Introduction Direct-to-family clinical trials efficiently provide data while reducing the participation burden for children and their families. Although these trials can offer significant advantages over traditional clinical trials, the process of designing and implementing direct-to-family studies is poorly defined, especially in children with rheumatic disease. This paper provides lessons learnt from the design and implementation of a self-controlled, direct-to-family pilot trial aimed to evaluate the effects of a medication management device on adherence to hydroxychloroquine in paediatric SLE.Methods Several design features accommodate a direct-to-family approach. Participants meeting eligibility criteria from across the USA were identified a priori through a disease registry, and all outcome data are collected remotely. The primary outcome (medication adherence) is evaluated using electronic medication event-monitoring, plasma drug levels, patient questionnaires and pill counts. Secondary and exploratory endpoints include (1) lupus disease activity measured by a remote SLE Disease Activity Index examination and the Systemic Lupus Activity Questionnaire; and (2) hydroxychloroquine pharmacokinetics and pharmacodynamics. Recruitment of the initial target of 20 participants was achieved within 10 days. Due to initial recruitment success, enrolment was increased to 26 participants. Additional participants who were interested were placed on a waiting list in case of dropouts during the study.Discussion and dissemination Direct-to-family trials offer several advantages but present unique challenges. Lessons learnt from the protocol development, design, and implementation of this trial will inform future direct-to-family trials for children and adults with rheumatic diseases. Additionally, the data collected remotely in this trial will provide critical information regarding the accuracy of teleresearch in lupus, the impact of adherence to hydroxychloroquine on disease activity and a pharmacokinetic analysis to inform paediatric-specific dosing of hydroxychloroquine.Trial registration number ClinicalTrials.gov Registry (NCT04358302).
Published: 2021
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7. Health Equity Implications of Missing Data Among Youths With Childhood‐OnsetSystemic Lupus Erythematosus: A Proof‐of‐ConceptStudy in the Childhood Arthritis and Rheumatology Research Alliance Registry

Author: Woo, Jennifer M. P., Simmonds, Faith, Dennos, Anne, Son, Mary Beth F., Lewandowski, Laura B., Rubinstein, Tamar B., Abel, N., Abulaban, K., Adams, A., Adams, M., Agbayani, R., Aiello, J., Akoghlanian, S., Alejandro, C., Allenspach, E., Alperin, R., Alpizar, M., Amarilyo, G., Ambler, W., Anderson, E., Ardoin, S., Armendariz, S., Baker, E., Balboni, I., Balevic, S., Ballenger, L., Ballinger, S., Balmuri, N., Barbar‐Smiley, F., Barillas‐Arias, L., Basiaga, M., Baszis, K., Becker, M., Bell‐Brunson, H., Beltz, E., Benham, H., Benseler, S., Bernal, W., Beukelman, T., Bigley, T., Binstadt, B., Black, C., Blakley, M., Bohnsack, J., Boland, J., Boneparth, A., Bowman, S., Bracaglia, C., Brooks, E., Brothers, M., Brown, A., Brunner, H., Buckley, M., Buckley, M., Bukulmez, H., Bullock, D., Cameron, B., Canna, S., Cannon, L., Carper, P., Cartwright, V., Cassidy, E., Cerracchio, L., Chalom, E., Chang, J., Chang‐Hoftman, A., Chauhan, V., Chira, P., Chinn, T., Chundru, K., Clairman, H., Co, D., Confair, A., Conlon, H., Connor, R., Cooper, A., Cooper, J., Cooper, S., Correll, C., Corvalan, R., Costanzo, D., Cron, R., Curiel‐Duran, L., Curington, T., Curry, M., Dalrymple, A., Davis, A., Davis, C., Davis, C., Davis, T., De Benedetti, F., De Ranieri, D., Dean, J., Dedeoglu, F., DeGuzman, M., Delnay, N., Dempsey, V., DeSantis, E., Dickson, T., Dingle, J., Donaldson, B., Dorsey, E., Dover, S., Dowling, J., Drew, J., Driest, K., Du, Q., Duarte, K., Durkee, D., Duverger, E., Dvergsten, J., Eberhard, A., Eckert, M., Ede, K., Edelheit, B., Edens, C., Edens, C., Edgerly, Y., Elder, M., Ervin, B., Fadrhonc, S., Failing, C., Fair, D., Falcon, M., Favier, L., Federici, S., Feldman, B., Fennell, J., Ferguson, I., Ferguson, P., Ferreira, B., Ferrucho, R., Fields, K., Finkel, T., Fitzgerald, M., Fleming, C., Flynn, O., Fogel, L., Fox, E., Fox, M., Franco, L., Freeman, M., Fritz, K., Froese, S., Fuhlbrigge, R., Fuller, J., George, N., Gerhold, K., Gerstbacher, D., Gilbert, M., Gillispie‐Taylor, M., Giverc, E., Godiwala, C., Goh, I., Goheer, H., Goldsmith, D., Gotschlich, E., Gotte, A., Gottlieb, B., Gracia, C., Graham, T., Grevich, S., Griffin, T., Griswold, J., Grom, A., Guevara, M., Guittar, P., Guzman, M., Hager, M., Hahn, T., Halyabar, O., Hammelev, E., Hance, M., Hanson, A., Harel, L., Haro, S., Harris, J., Harry, O., Hartigan, E., Hausmann, J., Hay, A., Hayward, K., Heiart, J., Hekl, K., Henderson, L., Henrickson, M., Hersh, A., Hickey, K., Hill, P., Hillyer, S., Hiraki, L., Hiskey, M., Hobday, P., Hoffart, C., Holland, M., Hollander, M., Hong, S., Horwitz, M., Hsu, J., Huber, A., Huggins, J., Hui‐Yuen, J., Hung, C., Huntington, J., Huttenlocher, A., Ibarra, M., Imundo, L., Inman, C., Insalaco, A., Jackson, A., Jackson, S., James, K., Janow, G., Jaquith, J., Jared, S., Johnson, N., Jones, J., Jones, J., Jones, J., Jones, K., Jones, S., Joshi, S., Jung, L., Justice, C., Justiniano, A., Karan, N., Kaufman, K., Kemp, A., Kessler, E., Khalsa, U., Kienzle, B., Kim, S., Kimura, Y., Kingsbury, D., Kitcharoensakkul, M., Klausmeier, T., Klein, K., Klein‐Gitelman, M., Kompelien, B., Kosikowski, A., Kovalick, L., Kracker, J., Kramer, S., Kremer, C., Lai, J., Lam, J., Lang, B., Lapidus, S., Lapin, B., Lasky, A., Latham, D., Lawson, E., Laxer, R., Lee, P., Lee, P., Lee, T., Lentini, L., Lerman, M., Levy, D., Li, S., Lieberman, S., Lim, L., Lin, C., Ling, N., Lingis, M., Lo, M., Lovell, D., Lowman, D., Luca, N., Lvovich, S., Madison, C., Madison, J., Manzoni, S. Magni, Malla, B., Maller, J., Malloy, M., Mannion, M., Manos, C., Marques, L., Martyniuk, A., Mason, T., Mathus, S., McAllister, L., McCarthy, K., McConnell, K., McCormick, E., McCurdy, D., Stokes, P. McCurdy, McGuire, S., McHale, I., McMonagle, A., McMullen‐Jackson, C., Meidan, E., Mellins, E., Mendoza, E., Mercado, R., Merritt, A., Michalowski, L., Miettunen, P., Miller, M., Milojevic, D., Mirizio, E., Misajon, E., Mitchell, M., Modica, R., Mohan, S., Moore, K., Moorthy, L., Morgan, S., Dewitt, E. Morgan, Moss, C., Moussa, T., Mruk, V., Murphy, A., Muscal, E., Nadler, R., Nahal, B., Nanda, K., Nasah, N., Nassi, L., Nativ, S., Natter, M., Neely, J., Nelson, B., Newhall, L., Ng, L., Nicholas, J., Nicolai, R., Nigrovic, P., Nocton, J., Nolan, B., Oberle, E., Obispo, B., O'Brien, B., O'Brien, T., Okeke, O., Oliver, M., Olson, J., O'Neil, K., Onel, K., Orandi, A., Orlando, M., Osei‐Onomah, S., Oz, R., Pagano, E., Paller, A., Pan, N., Panupattanapong, S., Pardeo, M., Paredes, J., Parsons, A., Patel, J., Pentakota, K., Pepmueller, P., Pfeiffer, T., Phillippi, K., Phillippi, K., Marafon, D. Pires, Ponder, L., Pooni, R., Prahalad, S., Pratt, S., Protopapas, S., Puplava, B., Quach, J., Quinlan‐Waters, M., Rabinovich, C., Radhakrishna, S., Rafko, J., Raisian, J., Rakestraw, A., Ramirez, C., Ramsay, E., Ramsey, S., Randell, R., Reed, A., Reed, A., Reed, A., Reid, H., Remmel, K., Repp, A., Reyes, A., Richmond, A., Riebschleger, M., Ringold, S., Riordan, M., Riskalla, M., Ritter, M., Rivas‐Chacon, R., Robinson, A., Rodela, E., Rodriquez, M., Rojas, K., Ronis, T., Rosenkranz, M., Rosolowski, B., Rothermel, H., Rothman, D., Roth‐Wojcicki, E., Rouster‐Stevens, K., Rubinstein, T., Ruth, N., Saad, N., Sabbagh, S., Sacco, E., Sadun, R., Sandborg, C., Sanni, A., Santiago, L., Sarkissian, A., Savani, S., Scalzi, L., Schanberg, L., Scharnhorst, S., Schikler, K., Schlefman, A., Schmeling, H., Schmidt, K., Schmitt, E., Schneider, R., Schollaert‐Fitch, K., Schulert, G., Seay, T., Seper, C., Shalen, J., Sheets, R., Shelly, A., Shenoi, S., Shergill, K., Shirley, J., Shishov, M., Shivers, C., Silverman, E., Singer, N., Sivaraman, V., Sletten, J., Smith, A., Smith, C., Smith, J., Smith, J., Smitherman, E., Soep, J., Son, M., Spence, S., Spiegel, L., Spitznagle, J., Sran, R., Srinivasalu, H., Stapp, H., Steigerwald, K., Rakovchik, Y. Sterba, Stern, S., Stevens, A., Stevens, B., Stevenson, R., Stewart, K., Stingl, C., Stokes, J., Stoll, M., Stringer, E., Sule, S., Sumner, J., Sundel, R., Sutter, M., Syed, R., Syverson, G., Szymanski, A., Taber, S., Tal, R., Tambralli, A., Taneja, A., Tanner, T., Tapani, S., Tarshish, G., Tarvin, S., Tate, L., Taxter, A., Taylor, J., Terry, M., Tesher, M., Thatayatikom, A., Thomas, B., Tiffany, K., Ting, T., Tipp, A., Toib, D., Torok, K., Toruner, C., Tory, H., Toth, M., Tse, S., Tubwell, V., Twilt, M., Uriguen, S., Valcarcel, T., Van Mater, H., Vannoy, L., Varghese, C., Vasquez, N., Vazzana, K., Vehe, R., Veiga, K., Velez, J., Verbsky, J., Vilar, G., Volpe, N., Scheven, E., Vora, S., Wagner, J., Wagner‐Weiner, L., Wahezi, D., Waite, H., Walker, J., Walters, H., Muskardin, T. Wampler, Waqar, L., Waterfield, M., Watson, M., Watts, A., Weiser, P., Weiss, J., Weiss, P., Wershba, E., White, A., Williams, C., Wise, A., Woo, J., Woolnough, L., Wright, T., Wu, E., Yalcindag, A., Yee, M., Yen, E., Yeung, R., Yomogida, K., Yu, Q., Zapata, R., Zartoshti, A., Zeft, A., Zeft, R., Zhang, Y., Zhao, Y., Zhu, A., and Zic, C.
Abstract: Health disparities in childhood‐onset systemic lupus erythematosus (SLE) disproportionately impact marginalized populations. Socioeconomically patterned missing data can magnify existing health inequities by supporting inferences that may misrepresent populations of interest. Our objective was to assess missing data and subsequent health equity implications among participants with childhood‐onset SLE enrolled in a large pediatric rheumatology registry. We evaluated co‐missingness of 12 variables representing demographics, socioeconomic position, and clinical factors (e.g., disease‐related indices) using Childhood Arthritis and Rheumatology Research Alliance Registry childhood‐onset SLE enrollment data (2015–2022; n = 766). We performed logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs) for missing disease‐related indices at enrollment (Systemic Lupus Erythematosus Disease Activity Index 2000 [SLEDAI‐2K] and/or Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index [SDI]) associated with data missingness. We used linear regression to assess the association between socioeconomic factors and SLEDAI‐2K at enrollment using 3 analytic methods for missing data: complete case analysis, multiple imputation, and nonprobabilistic bias analyses, with missing values imputed to represent extreme low or high disadvantage. On average, participants were missing 6.2% of data, with over 50% of participants missing at least 1 variable. Missing data correlated most closely with variables within data categories (i.e., demographic). Government‐assisted health insurance was associated with missing SLEDAI‐2K and/or SDI scores compared to private health insurance (OR 2.04 [95% CI 1.22, 3.41]). The different analytic approaches resulted in varying analytic sample sizes and fundamentally conflicting estimated associations. Our results support intentional evaluation of missing data to inform effect estimate interpretation and critical assessment of causal statements that might otherwise misrepresent health inequities.
Published: 2023
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8. Childhood‐OnsetLupus Nephritis in the Childhood Arthritis and Rheumatology Research Alliance Registry: Short‐TermKidney Status and Variation in Care

Author: Smitherman, Emily A., Chahine, Rouba A., Beukelman, Timothy, Lewandowski, Laura B., Rahman, A. K. M. Fazlur, Wenderfer, Scott E., Curtis, Jeffrey R., Hersh, Aimee O., Abel, N., Abulaban, K., Adams, A., Adams, M., Agbayani, R., Aiello, J., Akoghlanian, S., Alejandro, C., Allenspach, E., Alperin, R., Alpizar, M., Amarilyo, G., Ambler, W., Anderson, E., Ardoin, S., Armendariz, S., Baker, E., Balboni, I., Balevic, S., Ballenger, L., Ballinger, S., Balmuri, N., Barbar‐Smiley, F., Barillas‐Arias, L., Basiaga, M., Baszis, K., Becker, M., Bell‐Brunson, H., Beltz, E., Benham, H., Benseler, S., Bernal, W., Beukelman, T., Bigley, T., Binstadt, B., Black, C., Blakley, M., Bohnsack, J., Boland, J., Boneparth, A., Bowman, S., Bracaglia, C., Brooks, E., Brothers, M., Brown, A., Brunner, H., Buckley, M., Buckley, M., Bukulmez, H., Bullock, D., Cameron, B., Canna, S., Cannon, L., Carper, P., Cartwright, V., Cassidy, E., Cerracchio, L., Chalom, E., Chang, J., Chang‐Hoftman, A., Chauhan, V., Chira, P., Chinn, T., Chundru, K., Clairman, H., Co, D., Confair, A., Conlon, H., Connor, R., Cooper, A., Cooper, J., Cooper, S., Correll, C., Corvalan, R., Costanzo, D., Cron, R., Curiel‐Duran, L., Curington, T., Curry, M., Dalrymple, A., Davis, A., Davis, C., Davis, C., Davis, T., De Benedetti, F., De Ranieri, D., Dean, J., Dedeoglu, F., DeGuzman, M., Delnay, N., Dempsey, V., DeSantis, E., Dickson, T., Dingle, J., Donaldson, B., Dorsey, E., Dover, S., Dowling, J., Drew, J., Driest, K., Du, Q., Duarte, K., Durkee, D., Duverger, E., Dvergsten, J., Eberhard, A., Eckert, M., Ede, K., Edelheit, B., Edens, C., Edens, C., Edgerly, Y., Elder, M., Ervin, B., Fadrhonc, S., Failing, C., Fair, D., Falcon, M., Favier, L., Federici, S., Feldman, B., Fennell, J., Ferguson, I., Ferguson, P., Ferreira, B., Ferrucho, R., Fields, K., Finkel, T., Fitzgerald, M., Fleming, C., Flynn, O., Fogel, L., Fox, E., Fox, M., Franco, L., Freeman, M., Fritz, K., Froese, S., Fuhlbrigge, R., Fuller, J., George, N., Gerhold, K., Gerstbacher, D., Gilbert, M., Gillispie‐Taylor, M., Giverc, E., Godiwala, C., Goh, I., Goheer, H., Goldsmith, D., Gotschlich, E., Gotte, A., Gottlieb, B., Gracia, C., Graham, T., Grevich, S., Griffin, T., Griswold, J., Grom, A., Guevara, M., Guittar, P., Guzman, M., Hager, M., Hahn, T., Halyabar, O., Hammelev, E., Hance, M., Hanson, A., Harel, L., Haro, S., Harris, J., Harry, O., Hartigan, E., Hausmann, J., Hay, A., Hayward, K., Heiart, J., Hekl, K., Henderson, L., Henrickson, M., Hersh, A., Hickey, K., Hill, P., Hillyer, S., Hiraki, L., Hiskey, M., Hobday, P., Hoffart, C., Holland, M., Hollander, M., Hong, S., Horwitz, M., Hsu, J., Huber, A., Huggins, J., Hui‐Yuen, J., Hung, C., Huntington, J., Huttenlocher, A., Ibarra, M., Imundo, L., Inman, C., Insalaco, A., Jackson, A., Jackson, S., James, K., Janow, G., Jaquith, J., Jared, S., Johnson, N., Jones, J., Jones, J., Jones, J., Jones, K., Jones, S., Joshi, S., Jung, L., Justice, C., Justiniano, A., Karan, N., Kaufman, K., Kemp, A., Kessler, E., Khalsa, U., Kienzle, B., Kim, S., Kimura, Y., Kingsbury, D., Kitcharoensakkul, M., Klausmeier, T., Klein, K., Klein‐Gitelman, M., Kompelien, B., Kosikowski, A., Kovalick, L., Kracker, J., Kramer, S., Kremer, C., Lai, J., Lam, J., Lang, B., Lapidus, S., Lapin, B., Lasky, A., Latham, D., Lawson, E., Laxer, R., Lee, P., Lee, P., Lee, T., Lentini, L., Lerman, M., Levy, D., Li, S., Lieberman, S., Lim, L., Lin, C., Ling, N., Lingis, M., Lo, M., Lovell, D., Lowman, D., Luca, N., Lvovich, S., Madison, C., Madison, J., Manzoni, S. Magni, Malla, B., Maller, J., Malloy, M., Mannion, M., Manos, C., Marques, L., Martyniuk, A., Mason, T., Mathus, S., McAllister, L., McCarthy, K., McConnell, K., McCormick, E., McCurdy, D., Stokes, P. McCurdy, McGuire, S., McHale, I., McMonagle, A., McMullen‐Jackson, C., Meidan, E., Mellins, E., Mendoza, E., Mercado, R., Merritt, A., Michalowski, L., Miettunen, P., Miller, M., Milojevic, D., Mirizio, E., Misajon, E., Mitchell, M., Modica, R., Mohan, S., Moore, K., Moorthy, L., Morgan, S., Dewitt, E. Morgan, Moss, C., Moussa, T., Mruk, V., Murphy, A., Muscal, E., Nadler, R., Nahal, B., Nanda, K., Nasah, N., Nassi, L., Nativ, S., Natter, M., Neely, J., Nelson, B., Newhall, L., Ng, L., Nicholas, J., Nicolai, R., Nigrovic, P., Nocton, J., Nolan, B., Oberle, E., Obispo, B., O'Brien, B., O'Brien, T., Okeke, O., Oliver, M., Olson, J., O'Neil, K., Onel, K., Orandi, A., Orlando, M., Osei‐Onomah, S., Oz, R., Pagano, E., Paller, A., Pan, N., Panupattanapong, S., Pardeo, M., Paredes, J., Parsons, A., Patel, J., Pentakota, K., Pepmueller, P., Pfeiffer, T., Phillippi, K., Marafon, D. Pires, Phillippi, K., Ponder, L., Pooni, R., Prahalad, S., Pratt, S., Protopapas, S., Puplava, B., Quach, J., Quinlan‐Waters, M., Rabinovich, C., Radhakrishna, S., Rafko, J., Raisian, J., Rakestraw, A., Ramirez, C., Ramsay, E., Ramsey, S., Randell, R., Reed, A., Reed, A., Reed, A., Reid, H., Remmel, K., Repp, A., Reyes, A., Richmond, A., Riebschleger, M., Ringold, S., Riordan, M., Riskalla, M., Ritter, M., Rivas‐Chacon, R., Robinson, A., Rodela, E., Rodriquez, M., Rojas, K., Ronis, T., Rosenkranz, M., Rosolowski, B., Rothermel, H., Rothman, D., Roth‐Wojcicki, E., Rouster – Stevens, K., Rubinstein, T., Ruth, N., Saad, N., Sabbagh, S., Sacco, E., Sadun, R., Sandborg, C., Sanni, A., Santiago, L., Sarkissian, A., Savani, S., Scalzi, L., Schanberg, L., Scharnhorst, S., Schikler, K., Schlefman, A., Schmeling, H., Schmidt, K., Schmitt, E., Schneider, R., Schollaert‐Fitch, K., Schulert, G., Seay, T., Seper, C., Shalen, J., Sheets, R., Shelly, A., Shenoi, S., Shergill, K., Shirley, J., Shishov, M., Shivers, C., Silverman, E., Singer, N., Sivaraman, V., Sletten, J., Smith, A., Smith, C., Smith, J., Smith, J., Smitherman, E., Soep, J., Son, M., Spence, S., Spiegel, L., Spitznagle, J., Sran, R., Srinivasalu, H., Stapp, H., Steigerwald, K., Rakovchik, Y. Sterba, Stern, S., Stevens, A., Stevens, B., Stevenson, R., Stewart, K., Stingl, C., Stokes, J., Stoll, M., Stringer, E., Sule, S., Sumner, J., Sundel, R., Sutter, M., Syed, R., Syverson, G., Szymanski, A., Taber, S., Tal, R., Tambralli, A., Taneja, A., Tanner, T., Tapani, S., Tarshish, G., Tarvin, S., Tate, L., Taxter, A., Taylor, J., Terry, M., Tesher, M., Thatayatikom, A., Thomas, B., Tiffany, K., Ting, T., Tipp, A., Toib, D., Torok, K., Toruner, C., Tory, H., Toth, M., Tse, S., Tubwell, V., Twilt, M., Uriguen, S., Valcarcel, T., Van Mater, H., Vannoy, L., Varghese, C., Vasquez, N., Vazzana, K., Vehe, R., Veiga, K., Velez, J., Verbsky, J., Vilar, G., Volpe, N., Scheven, E., Vora, S., Wagner, J., Wagner‐Weiner, L., Wahezi, D., Waite, H., Walker, J., Walters, H., Muskardin, T. Wampler, Waqar, L., Waterfield, M., Watson, M., Watts, A., Weiser, P., Weiss, J., Weiss, P., Wershba, E., White, A., Williams, C., Wise, A., Woo, J., Woolnough, L., Wright, T., Wu, E., Yalcindag, A., Yee, M., Yen, E., Yeung, R., Yomogida, K., Yu, Q., Zapata, R., Zartoshti, A., Zeft, A., Zeft, R., Zhang, Y., Zhao, Y., Zhu, A., and Zic, C.
Abstract: The goal was to characterize short‐term kidney status and describe variation in early care utilization in a multicenter cohort of patients with childhood‐onset systemic lupus erythematosus (cSLE) and nephritis. We analyzed previously collected prospective data from North American patients with cSLE with kidney biopsy‐proven nephritis enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry from March 2017 through December 2019. We determined the proportion of patients with abnormal kidney status at the most recent registry visit and applied generalized linear mixed models to identify associated factors. We also calculated frequency of medication use, both during induction and ever recorded. We identified 222 patients with kidney biopsy–proven nephritis, with 64% class III/IV nephritis on initial biopsy. At the most recent registry visit at median (interquartile range) of 17 (8–29) months from initial kidney biopsy, 58 of 106 patients (55%) with available data had abnormal kidney status. This finding was associated with male sex (odds ratio [OR] 3.88, 95% confidence interval [95% CI] 1.21–12.46) and age at cSLE diagnosis (OR 1.23, 95% CI 1.01–1.49). Patients with class IV nephritis were more likely than class III to receive cyclophosphamide and rituximab during induction. There was substantial variation in mycophenolate, cyclophosphamide, and rituximab ever use patterns across rheumatology centers. In this cohort with predominately class III/IV nephritis, male sex and older age at cSLE diagnosis were associated with abnormal short‐term kidney status. We also observed substantial variation in contemporary medication use for pediatric lupus nephritis between pediatric rheumatology centers. Additional studies are needed to better understand the impact of this variation on long‐term kidney outcomes.
Published: 2023
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9. Delivering clinical trials at home: protocol, design and implementation of a direct-to-family paediatric lupus trial

Author: E Schmitt, C Smith, G Schulert, S Canna, A Grom, E Mellins, A Brown, A Stevens, M Watson, K Stewart, E Baker, A Kemp, T Davis, A Smith, S Jackson, K Jones, T Mason, A Hanson, Y Zhao, J Jones, J Chang, M Holland, K Moore, B ferreira, H Schmeling, K Abulaban, R Agbayani, S Akoghlanian, E Anderson, L Barillas-Arias, K Baszis, M Becker, H Bell-Brunson, H Benham, S Benseler, T Beukelman, H Brunner, H Bukulmez, L Cerracchio, E Chalom, K Chundru, J Dean, F Dedeoglu, V Dempsey, J Drew, B Feldman, P Ferguson, C Fleming, L Franco, I Goh, D Goldsmith, B Gottlieb, T Graham, T Griffin, M Hance, K Hickey, M Hollander, J Hsu, A Huber, C Hung, A Huttenlocher, L Imundo, C Inman, J Jaquith, L Jung, D Kingsbury, K Klein, M Klein-Gitelman, S Kramer, S Lapidus, D Latham, B Malla, M Malloy, A Martyniuk, K McConnell, D McCurdy, C McMullen-Jackson, L Moorthy, E Muscal, J Olson, K Onel, L Ponder, S Prahalad, C Rabinovich, S Ringold, M Riordan, A Robinson, M Rosenkranz, B Rosolowski, N Ruth, K Schikler, H Stapp, R Syed, M Tesher, A Thatayatikom, R Vehe, E von Scheven, D Wahezi, A Watts, J Weiss, S Kim, J Patel, J Stokes, L Marques, Stephen J Balevic, D Lovell, A Zeft, J Harris, E Lawson, C Moss, N George, Rachel L Randell, M Adams, S Cooper, M Miller, C Black, R Schneider, J Taylor, R Sran, M Oliver, M Twilt, M Tóth, J Walker, M Mitchell, F De Benedetti, N Singer, M Fox, K Kaufman, A Merritt, R Stevenson, J Fuller, M Fitzgerald, A Davis, C Davis, L Henderson, J Woo, S Mohan, H Reid, Y Kimura, L Harel, R Laxer, K McCarthy, I Ferguson, E McCormick, M Guzman, P Hill, A PARSONS, S McGuire, J Lam, C Sandborg, B Stevens, J Boland, S Ballinger, E MENDOZA, J NOCTON, M Ritter, N Johnson, J Shirley, S Bowman, M Ibarra, S Hong, M Guevara, K James, L Santiago, A Adams, B DONALDSON, M Son, C Kremer, K Schmidt, T Wright, L Cannon, R Nicolai, M Freeman, S Spence, D Levy, J Paredes, K Gerhold, A Insalaco, T O'Brien, W Bernal, E Kessler, C Lin, M Lerman, T Hahn, B O'Brien, Lindsay Singler, Anthony Cunningham, Michael Cohen-Wolkowiez, Christoph P Hornik, N Abel, J Aiello, C Alejandro, E Allenspach, R Alperin, M Alpizar, G Amarilyo, W Ambler, S Ardoin, S Armendariz, I Balboni, S Balevic, L Ballenger, N Balmuri, F Barbar-Smiley, M Basiaga, E Beltz, T Bigley, B Binstadt, M Blakley, J Bohnsack, A Boneparth, C Bracaglia, E Brooks, M Brothers, M Buckley, D Bullock, B Cameron, P Carper, V Cartwright, E Cassidy, A Chang-Hoftman, V Chauhan, P Chira, T Chinn, H Clairman, D Co, A Confair, H Conlon, R Connor, C Correll, R Corvalan, D Costanzo, R Cron, L Curiel-Duran, T Curington, M Curry, A Dalrymple, D De Ranieri, M De Guzman, N Delnay, E DeSantis, T Dickson, J Dingle, E Dorsey, S Dover, J Dowling, K Driest, Q Du, K Duarte, D Durkee, E Duverger, J Dvergsten, A Eberhard, M Eckert, K Ede, B Edelheit, C Edens, Y Edgerly, M Elder, B Ervin, S Fadrhonc, C Failing, D Fair, M Falcon, S Federici, J Fennell, R Ferrucho, K Fields, T Finkel, O Flynn, L Fogel, K Fritz, S Froese, R Fuhlbrigge, D Gerstbacher, M Gilbert, M Gillispie-Taylor, E Giverc, C Godiwala, H Goheer, E Gotschlich, A Gotte, C Gracia, S Grevich, J Griswold, P Guittar, M Hager, O Halyabar, E Hammelev, S Haro, O Harry, E Hartigan, J Hausmann, J Heiart, K Hekl, M Henrickson, A Hersh, S Hillyer, L Hiraki, M Hiskey, P Hobday, C Hoffart, M Horwitz, J Huggins, J HuiYuen, J Huntington, G Janow, S Jared, C Justice, A Justiniano, N Karan, U Khalsa, B Kienzle, M Kitcharoensakkul, T Klausmeier, B Kompelien, A Kosikowski, L Kovalick, J Kracker, J Lai, B Lang, B Lapin, A Lasky, L Lentini, S Lieberman, N Ling, M Lingis, M Lo, D Lowman, N Luca, S Lvovich, C Madison, J Madison, S Magni Manzoni, J Maller, M Mannion, C Manos, S Mathus, L McAllister, P McCurdy Stokes, I McHale, A McMonagle, E Meidan, R Mercado, L Michalowski, P Miettunen, D Milojevic, E Mirizio, E Misajon, R Modica, E Morgan Dewitt, T Moussa, V Mruk, R Nadler, B Nahal, K Nanda, N Nasah, L Nassi, S Nativ, M Natter, J Neely, B Nelson, L Newhall, L Ng, P Nigrovic, B Nolan, E Oberle, B Obispo, O Okeke, K O'Neil, A Orandi, M Orlando, S Osei-Onomah, R Oz, A Paller, N Pan, S Panupattanapong, M Pardeo, K Pentakota, P Pepmueller, T Pfeiffer, K Phillippi, D Pires Marafon, R Pooni, S Pratt, S Protopapas, B Puplava, J Quach, M Quinlan-Waters, S Radhakrishna, J Rafko, J Raisian, A Rakestraw, E Ramsay, S Ramsey, R Randell, K Remmel, A Repp, A Reyes, A Richmond, M Riebschleger, M Riskalla, R Rivas-Chacon, E Rodela, M Rodriquez, K Rojas, T Ronis, H Rothermel, D Rothman, E Roth-Wojcicki, K Rouster-Stevens, T Rubinstein, N Saad, S Sabbagh, E Sacco, R Sadun, A Sanni, A Sarkissian, S Savani, L Scalzi, L Schanberg, S Scharnhorst, A Schlefman, K Schollaert-Fitch, T Seay, C Seper, J Shalen, R Sheets, A Shelly, S Shenoi, K Shergill, M Shishov, C Shivers, E Silverman, V Sivaraman, J Sletten, E Smitherman, J Soep, L Spiegel, J Spitznagle, H Srinivasalu, K Steigerwald, Y Sterba Rakovchik, S Stern, C Stingl, M Stoll, E Stringer, S Sule, J Sumner, R Sundel, G Syverson, A Szymanski, S Taber, R Tal, A Tambralli, A Taneja, T Tanner, S Tapani, G Tarshish, S Tarvin, L Tate, A Taxter, M Terry, K Tiffany, T Ting, A Tipp, D Toib, K Torok, C Toruner, H Tory, S Tse, V Tubwell, S Uriguen, T Valcarcel, H Van Mater, L Vannoy, C Varghese, N Vasquez, K Vazzana, K Veiga, J Velez, J Verbsky, G Vilar, N Volpe, S Vora, L Wagner-Weiner, H Waite, H Walters, T Wampler Muskardin, L Waqar, M Waterfield, P Weiser, P Weiss, E Wershba, A Wise, L Woolnough, E Wu, A Yalcindag, M Yee, E Yen, R Yeung, K Yomogida, Q Yu, R Zapata, A Zartoshti, R Zeft, A Zhu, and C Zic
Subjects: medicine.medical_specialty, antirheumatic agents, Immunology, 03 medical and health sciences, 0302 clinical medicine, Disease registry, systemic lupus erythematosus, Protocol design, medicine, Protocol, Humans, Lupus Erythematosus, Systemic, autoimmune diseases, 030212 general & internal medicine, Dosing, Intensive care medicine, Child, 030203 arthritis & rheumatology, Protocol (science), Clinical Trials as Topic, Systemic lupus erythematosus, business.industry, SARS-CoV-2, COVID-19, Hydroxychloroquine, General Medicine, RC581-607, medicine.disease, Clinical trial, Treatment Outcome, Pill, Immunologic diseases. Allergy, Drug Monitoring, business, medicine.drug
Abstract: IntroductionDirect-to-family clinical trials efficiently provide data while reducing the participation burden for children and their families. Although these trials can offer significant advantages over traditional clinical trials, the process of designing and implementing direct-to-family studies is poorly defined, especially in children with rheumatic disease. This paper provides lessons learnt from the design and implementation of a self-controlled, direct-to-family pilot trial aimed to evaluate the effects of a medication management device on adherence to hydroxychloroquine in paediatric SLE.MethodsSeveral design features accommodate a direct-to-family approach. Participants meeting eligibility criteria from across the USA were identified a priori through a disease registry, and all outcome data are collected remotely. The primary outcome (medication adherence) is evaluated using electronic medication event-monitoring, plasma drug levels, patient questionnaires and pill counts. Secondary and exploratory endpoints include (1) lupus disease activity measured by a remote SLE Disease Activity Index examination and the Systemic Lupus Activity Questionnaire; and (2) hydroxychloroquine pharmacokinetics and pharmacodynamics. Recruitment of the initial target of 20 participants was achieved within 10 days. Due to initial recruitment success, enrolment was increased to 26 participants. Additional participants who were interested were placed on a waiting list in case of dropouts during the study.Discussion and disseminationDirect-to-family trials offer several advantages but present unique challenges. Lessons learnt from the protocol development, design, and implementation of this trial will inform future direct-to-family trials for children and adults with rheumatic diseases. Additionally, the data collected remotely in this trial will provide critical information regarding the accuracy of teleresearch in lupus, the impact of adherence to hydroxychloroquine on disease activity and a pharmacokinetic analysis to inform paediatric-specific dosing of hydroxychloroquine.Trial registration numberClinicalTrials.gov Registry (NCT04358302).
Published: 2021

10. 27 Therapeutic role of pelvic and para-aortic lymphadenectomy in apparent early stage epithelial ovarian cancer

Author: N Bizzarri, A Du Bois, R Fruscio, F De Felice, P De Iaco, J Casarin, E Vizza, V Chiantera, G Corrado, S Cianci, P Harter, B Ataseven, M Bommert, AM Perrone, S Magni, D Ferrari, B Zambetti, G Scambia, and A Fagotti
Published: 2020
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11. POS1385 INTERNATIONAL CONSENSUS FOR ULTRASOUND DEFINITIONS OF TENOSYNOVITIS IN JUVENILE IDIOPATHIC ARTHRITIS: RESULTS OF A DELPHI PROCESS

Author: P. Collado, S. Lanni, O. De Lucia, P. Balint, S. Guillaume, C. Hernandez-Diaz, N. M. K. Sande, S. Magni-Manzoni, C. Malattia, V. Martire, L. Rossi-Semerano, J. Roth, T. Ting, P. Vega Fernandez, D. Windschall, M. A. D’agostino, and E. Naredo
Subjects: Rheumatology, Immunology, Immunology and Allergy, General Biochemistry, Genetics and Molecular Biology
Abstract: BackgroundMusculoskeletal Ultrasonography (US) is a suitable tool for the clinical assessment in juvenile idiopathic arthritis (JIA). Recently US definitions for normal components of pediatric joints and synovitis have been developed by the OMERACT US working group. Currently this group is working on development and validation of US definition for tenosynovitis as it is also an essential prerequisite for the reliable use of this technology in the pediatric age group.ObjectivesTo produce consensus-based definitions for US tenosynovitis in JIA through a Delphi process.MethodsWe undertook a Delphi process on US-defined tenosynovitis in children that consisted of two steps. As a prior systematic literature review showed that US anatomy of the tendons is similar to adults, a Delphi questionnaire was written based on the consensual definitions developed for and used in adults with rheumatoid arthritis [1, 2]. The Delphi questionnaire was sent to rheumatologists and pediatricians who perform pediatric US examination, asking them to rate their level of agreement with each statement of US-defined tenosynovitis. Group agreement was considered if ≥80% of responders scored an item as either 4 or 5.In the second step, the definitions were validated on 88 standardized US images displaying various degrees of tenosynovitis obtained from JIA patients at various ages. Tendons often involved in JIA were selected (foot and ankle tendons, hand and wrist tendons, bicep tendon.). US images of both normal and tenosynovitis elementary lesions were collected by the 18 experts participating in the OMERACT US task force on pediatric tenosynovitis. An agreement ≥70% was considered mandatory for accepting the definition as applicable in the rated image.ResultsThe response rate was 75% (28 out of 37) from the first Delphi questionnaire. Strong group agreement (≥86%) was obtained for the US definitions tested. The response rate was 88.9% (16 out of 18) from the Web-exercise after four rounds. The final definitions were validated on still images for all tendons, except for the biceps tenosynovitis in the age group 2-4 years (the definitions of elementary lesions and the global definition of tenosynovitis) as no image was available for this location and age group. Despite not reaching group agreement after the second and the third round for the US-defined normal finger pulley in children aged 8 years and younger (roughly 68% and 69% respectively), it reached a score of 99.8% after the fourth round.ConclusionUS definitions of tenosynovitis and its elementary components covering a wide pediatric age range were successfully developed through a Delphi questionnaire and validated in a web-based still images exercise. These results provide the basis for the standardized US assessment of tenosynovitis in clinical practice.References[1]Ultrasound in the assessment of tenosynovitis in juvenile idiopathic arthritis: systematic literature review. Collado P on behalf of the OMERACT Ultrasound Task Force. DOI: 10.1136/annrheumdis-2019-eular.3493[2]Reliability of a consensus-based ultrasound score for tenosynovitis in rheumatoid arthritis. Naredo E on behalf of the OMERACT Ultrasound Task Force. Ann Rheum Dis 2013;72:1328AcknowledgementsAG Bruyn, L Terslev, S Jousse-Joulin, A Rodriguez, M Steiner, E Inarejos, P Bøyesen, K Misaki, A Iagnocco, B Marston, T Cazenave, P Mandl, A Bruns.Disclosure of InterestsNone declared
Published: 2022
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12. Evaluation of the power of six clustering features in identifying a homogeneous disease subset in juvenile idiopathic arthritis (JIA)

Author: Magnani A, Oliveira S, Castell E, Arguedas O, Ullmann N, Pederzoli S, Manzoni S Magni, Pistorio A, Ruperto N, Martini A, and Ravelli A
Subjects: Pediatrics, RJ1-570, Diseases of the musculoskeletal system, RC925-935
Published: 2008
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13. CARBON DIOXIDE AND METHANE EMISSIONS BY URBAN TURFGRASSES UNDER DIFFERENT NITROGEN RATES: A COMPARISON BETWEEN TALL FESCUE (FESTUCA ARUNDINACEA SCHREB.) AND HYBRID BERMUDAGRASS (CYNODON DACTYLON [L.] PERS. VAR. DACTYLON X CYNODON TRANSVAALENSIS BURTT-DAVY).

Author: G., BRANDANI, A., BALDI, L., CATUREGLI, M., GAETANI, N., GROSSI, S., MAGNI, A., PARDINI, M., VOLTERRANI, S., ORLANDINI, and L., VERDI
Subjects: BERMUDA grass, TALL fescue, CARBON emissions, TURFGRASSES, URBAN plants, URBAN climatology, CLIMATIC zones
Abstract: Turfgrass is a major vegetation type in urban and peri-urban areas. Being high maintenance ecosystems, turfs can contribute substantially to urban climate change. The object of this study was to evaluate the contribution to GHG emissions by urban turfgrasses in Mediterranean conditions (Tuscany, central Italy). CO2 and CH4 emission fluxes from a mature stand of tall fescue and bermudagrass were evaluated, by static chambers method, for the assessment of C emission under different nitrogen fertilization rates (0 - 50 - 150 kg N ha-1 ). Both species showed a correlation between N fertilization rate and CO2 emissions, whilst, no correlation was observed for CH4. In the case of tall fescue, cumulative CO2 emissions were significantly higher with 150 kg N ha-1 and no differences were observed between 0 and 50 kg N ha-1 . As for bermudagrass differences were found between control and other treatments but no differences were observed on cumulative CO2 emissions between 50 and 150 kg N ha-1 . In both species, N fertilization did not affect CH4 emissions. Results indicate that both N rate and turfgrass species influence C emissions, for this reason they should be considered in the management of green areas in the climatic transition zone. [ABSTRACT FROM AUTHOR]
Published: 2021
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14. Geant4—a simulation toolkit

Author: I. González, K. Murakami, A. Walkden, A. Heikkinen, Francesco Longo, M. Kawaguti, F. Lei, A. Grossheim, H. Uno, S. Agostinelli, Stefan Scherer, D. Zschiesche, M. Nagamatu, M. Takahata, W. S. Lockman, S. Garelli, Gene Cooperman, S. Magni, Veronique Lefebure, G. Gracia Abril, J Perl, K. Ohtsubo, Satoshi Tanaka, Torre Wenaus, F. Ranjard, G. Depaola, John Allison, Andreas Pfeiffer, M. Verderi, J. Chuma, G. Cosmo, R. Hamatsu, M. Liendl, Franca Foppiano, H. Fesefeldt, Naoko Kanaya, T. Kodama, Hisaya Kurashige, K. Minamimoto, E. Medernach, Vladimir Grichine, H. Hasui, Douglas Wright, Walter Greiner, A. Kimura, Andrea Dell'Acqua, R. Enami, S. Gianì, Stephane Chauvie, A. S. Howard, S. Banerjee, Lorenzo Bellagamba, Maria Grazia Pia, P. Arce, David J. Smith, M. Tropeano, M. Okamura, R. Nartallo, G. Greeniaus, K. Paech, Susanna Guatelli, T. Yamada, Vladimir Ivanchenko, D. Gibin, A. Johnson, J. Boudreau, P. Urban, Gunter Folger, M. Maire, J. Sulkimo, F.W. Jones, Y. Oohata, D. Dietrich, E. Lamanna, N. Starkov, Y. Kawabata, R. P. Kokoulin, P. Gumplinger, Petteri Nieminen, V. Sirotenko, S.S Sadilov, J. Kallenbach, J.P. Wellisch, P. Truscott, R. Giannitrapani, K. Hashimoto, M. Kawabata, D. Axen, Henrique Araujo, Makoto Asai, S. W. O'Neale, D.C. Williams, M. Kossov, L. Broglia, P. V. Degtyarenko, S. Sei, K. Amako, W. Wander, Paul R. C. Kent, E. Di Salvo, A. Brunengo, H. Yoshida, Giovanni Santin, H. Stoecker, C. Ferguson, Alessandra Forti, Y. Sawada, T. Nishimura, P. Mora de Freitas, A. Feliciello, J. Apostolakis, A.M. Rybin, J. J. Gomez Y Cadenas, G. Barrand, F. Behner, V. Lara, Tapio Lampén, N. Savvas, H. Burkhardt, H. Weber, E. Tcherniaev, Takashi Sasaki, L. Urbán, R. Chytracek, S.R. Kelner, Yoshiyuki Morita, E. Safai Tehrani, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), S., Agostinelli, J., Allison, K., Amako, J., Apostolaki, H., Araujo, P., Arce, M., Asai, D., Axen, S., Banerjee, G., Barrand, F., Behner, L., Bellagamba, J., Boudreau, L., Broglia, A., Brunengo, H., Burkhardt, S., Chauvie, J., Chuma, R., Chytracek, G., Cooperman, G., Cosmo, P., Degtyarenko, A., Dell'Acqua, G., Depaola, D., Dietrich, R., Enami, A., Feliciello, C., Ferguson, H., Fesefeldt, G., Folger, F., Foppiano, A., Forti, S., Garelli, S., Giani, R., Giannitrapani, D., Gibin, J. J., Gomez, I., Gonzalez, Abril, G., G., Greeniau, W., Greiner, V., Grichine, A., Grossheim, S., Guatelli, P., Gumplinger, R., Hamatsu, K., Hashimoto, H., Hasui, A., Heikkinen, A., Howard, V., Ivanchenko, A., Johnson, F. W., Jone, J., Kallenbach, N., Kanaya, M., Kawabata, Y., Kawabata, M., Kawaguti, S., Kelner, P., Kent, A., Kimura, T., Kodama, R., Kokoulin, M., Kossov, H., Kurashige, E., Lamanna, T., Lampen, V., Lara, V., Lefebure, F., Lei, M., Liendl, W., Lockman, Longo, Francesco, S., Magni, M., Maire, E., Medernach, K., Minamimoto, De, P., Y., Morita, K., Murakami, M., Nagamatu, R., Nartallo, P., Nieminen, T., Nishimura, K., Ohtsubo, M., Okamura, S., O'Neale, Y., Oohata, K., Paech, J., Perl, A., Pfeiffer, M. G., Pia, F., Ranjard, A., Rybin, S., Sadilov, Salvo, E., G., Santin, T., Sasaki, N., Savva, Y., Sawada, S., Scherer, S., Sei, V., Sirotenko, D., Smith, N., Starkov, H., Stoecker, J., Sulkimo, M., Takahata, S., Tanaka, E., Tcherniaev, Tehrani, E., M., Tropeano, P., Truscott, H., Uno, L., Urban, P., Urban, M., Verderi, A., Walkden, W., Wander, H., Weber, J. P., Wellisch, T., Wenau, D. C., William, D., Wright, T., Yamada, H., Yoshida, and D., Zschiesche
Subjects: Physics, Nuclear and High Energy Physics, Applied physics, business.industry, ATLAS experiment, Object Oriented Programming, 07.05.Tp, 13, 23, Tracking (particle physics), Search for the Higgs boson, Computing and Computers, Computational science, Montecarlo simulations, Radiation Interactions, Software, Particle shower, Montecarlo simulation, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], business, Adaptation (computer science), Instrumentation, Range (computer programming)
Abstract: G eant 4 is a toolkit for simulating the passage of particles through matter. It includes a complete range of functionality including tracking, geometry, physics models and hits. The physics processes offered cover a comprehensive range, including electromagnetic, hadronic and optical processes, a large set of long-lived particles, materials and elements, over a wide energy range starting, in some cases, from 250 eV and extending in others to the TeV energy range. It has been designed and constructed to expose the physics models utilised, to handle complex geometries, and to enable its easy adaptation for optimal use in different sets of applications. The toolkit is the result of a worldwide collaboration of physicists and software engineers. It has been created exploiting software engineering and object-oriented technology and implemented in the C++ programming language. It has been used in applications in particle physics, nuclear physics, accelerator design, space engineering and medical physics.
Published: 2003
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15. First look at the beam test results of the FPIX2 readout chip for the BTeV silicon pixel detector

Author: C. R. Newsom, H.P. Cease, Jing Wang, R. Coluccia, Simon Kwan, R.J. Yarema, V. Papavassiliou, J. Hoff, Dario Menasce, G. Cardoso, Marina Artuso, S. Magni, A. Schreiner, A. Mekkaoui, J.A. Appel, M. Turqueti, D.A. Cinabro, Lorenzo Uplegger, G. Chiodini, and D. C. Christian
Subjects: Physics, Nuclear and High Energy Physics, Pixel, Physics::Instrumentation and Detectors, business.industry, Detector, BTeV experiment, law.invention, Telescope, Nuclear Energy and Engineering, law, Nuclear electronics, Optoelectronics, High Energy Physics::Experiment, Fermilab, Electrical and Electronic Engineering, business, Beam (structure), Diode
Abstract: High energy and nuclear physics experiments need tracking devices with increasing spatial precision and readout speed in the face of ever-higher track densities and increased radiation environments. The new generation of hybrid pixel detectors (arrays of silicon diodes bump bonded to arrays of front-end electronic cells) is the technology able to meet these challenges. We report the first results of the BTeV silicon pixel detector beam test carried out at Fermilab in summer 2004. Tests were performed using a 120 GeV/c proton beam incident on a 6 plane pixel detector telescope. The last prototype developed for the BTeV experiment (FPIX2) is tested in the middle of the telescope. There is no external trigger, and events were built using the time-stamp information provided by the readout chips
Published: 2006
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16. Side-chain alkylation of toluene with methanol on Cs-exchanged NaY zeolites: effect of Cs loading

Author: A. Borgna, Jorge Sepúlveda, S. Magni, C.L. Padró, and Carlos Rodolfo Apesteguia
Subjects: chemistry.chemical_compound, chemistry, Inorganic chemistry, Side reaction, General Chemistry, Methanol, Alkylation, Zeolite, Ethylbenzene, Toluene, Catalysis, Styrene
Abstract: The side-chain alkylation of toluene with methanol was studied on Cs-exchanged NaY zeolites containing up to 31% Cs (exchange degree, ED, up to 70%). Formation of styrene and ethylbenzene was significant only on Na(Cs)Y zeolites of ED higher than about 40%. Bimolecular side-chain alkylation reaction would require a proper surface geometric configuration of Oδ−-Cs+ pairs that is achieved only on Cs-rich zeolites. In contrast, the side reaction forming carbon monoxide from methanol increases monotonically with increasing ED because it is essentially controlled by the basicity of the oxygen lattice.
Published: 2005
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17. Perturbated turbulent transport in a laboratory magnetoplasma: fluctuations, correlations and intermittency

Author: H. E. Roman, S. Magni, C Riccardi, Roman, H, Riccardi, C, and Magni, S
Subjects: Physics, History, Toroid, Field (physics), Turbulence, turbulence, Flux, Plasma, Computer Science Applications, Education, Computational physics, law.invention, Radial velocity, FIS/01 - FISICA SPERIMENTALE, Classical mechanics, Physics::Plasma Physics, law, Intermittency, intermittency, magnetoplasma, Particle density, FIS/03 - FISICA DELLA MATERIA
Abstract: The effects of an edge biasing potential on the intermittent behaviour of the anomalous flux in a cold toroidal magnetoplasma is studied at different radial positions in the poloidal plane. It is found that both the fluctuations and cross-correlations between particle density and radial velocity vary as a function of the applied bias potential, leading to a strong reduction of the flux at the plasma core. The reduction is due to a large extent to the conspicuous decorrelation between density and velocity signals, while the corresponding fluctuations are much less sensitive to the applied field. The study of intermittent bursts indicates that a strong increase in their mean waiting times takes place at the core.
Published: 2005
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18. Headache in the emergency department

Author: M. Bernareggi, S. Magni, and M. Gardinali
Subjects: Emergency Medical Services, medicine.medical_specialty, Headache Disorders, business.industry, Cluster headache, MEDLINE, Dermatology, General Medicine, Emergency department, medicine.disease, Psychiatry and Mental health, Primary headache, Migraine, Emergency medical services, medicine, Humans, Subarachnoid haemorrhage, Neurology (clinical), Neurosurgery, Medical emergency, business, Pain Measurement
Abstract: Patients with headache commonly seek care at an emergency department (ED). Patients with headache in fact account for between 1 and 2% of admissions to an ED. Therefore the ED physician must recognize symptoms and characteristics of headache that signal a potential significant organic problem in order to select appropriate tests and treatment. Key to the correct management of headache in ED is a careful, thorough history of the patient. This article summarizes what the ED physician should take into consideration in order to distinguish who simply needs reassurance and analgesia and who needs further investigation.
Published: 2004
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19. Effect of conjugated linoleic acid on meat quality, lipid metabolism, and sensory characteristics of dry-cured hams from heavy pigs1

Author: Raffaella Rossi, S. Magni, Grazia Pastorelli, Jacques Mourot, and Carlo Corino
Subjects: Taste, integumentary system, Chemistry, Animal feed, Conjugated linoleic acid, food and beverages, Lipid metabolism, General Medicine, Loin, chemistry.chemical_compound, Dose–response relationship, Longissimus, Semimembranosus muscle, Genetics, lipids (amino acids, peptides, and proteins), Animal Science and Zoology, Food science, Food Science
Abstract: We investigated conjugated linoleic acid (CLA) supplementation administered to heavy pigs, assessing carcass characteristics, meat quality, and sensory characteristics of dry-cured (Parma) ham. Thirty-six pigs, averaging 97 kg BW, were assigned randomly to three feeding groups in which diets were supplemented with either 0, 0.25, or 0.5% (as-fed basis) of a CLA preparation containing 65% CLA isomers. All pigs were slaughtered at 172 kg BW. No (P > 0.05) differences were observed in dressing percentage, loin and ham weight, or pH and color of longissimus and semimembranosus muscle. Tenth-rib backfat thickness tended to be lower (P 0.05) affected by incorporation of CLA. Results indicated that dietary CLA alters lipid metabolism, producing lower concentrations of monounsaturated fatty acids and increased concentrations of CLA isomers in the fat of heavy pigs. Moreover, supplementing diets with CLA produced only minimal improvements in Parma ham sensory traits and had no appreciable effects on fresh pork quality.
Published: 2003
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20. Influence of dietary conjugated linoleic acid on growth, meat quality, lipogenesis, plasma leptin and physiological variables of lipid metabolism in rabbits1

Author: F. Rosi, Jacques Mourot, Grazia Pastorelli, S. Magni, and Carlo Corino
Subjects: medicine.medical_specialty, Conjugated linoleic acid, Leptin, Linoleic acid, food and beverages, Adipose tissue, Lipid metabolism, General Medicine, Biology, Feed conversion ratio, chemistry.chemical_compound, Endocrinology, chemistry, Internal medicine, Lipogenesis, Genetics, medicine, Animal Science and Zoology, medicine.symptom, Weight gain, Food Science
Abstract: We investigated the effects of conjugated linoleic acid (CLA) supplementation on growth, feed efficiency, carcass characteristics, meat quality, lipogenesis, and lipid metabolism in rabbits. One hundred forty-four New Zealand White rabbits, half males, half females, age 55 d, mean 1.8 kg BW, were randomly assigned to three weight- and sex-balanced feeding groups in which conventional pelleted diets were supplemented with 0, 0.25, or 0.5% of a CLA preparation. The CLA preparation contained 65% CLA isomers. Twelve rabbits (six males and six females from each group) were slaughtered at each of three slaughtering trials (2.5, 2.8, and 3.1 kg BW, or 76, 90, and 104 d of age). Conjugated linoleic acid supplementation did not influence growth performance (P > or = 0.05) or carcass characteristics but reduced perirenal fat at heavier slaughtering weights (P = 0.09 at 2.8 kg BW; P < 0.01 at 3.1 kg BW). Conjugated linoleic acid reduced acetyl-CoA-carboxylase (CBX) activity in liver (P < 0.05) and adipose tissues (P < 0.01) but did not influence malic enzyme (ME) or glucose-6-phosphate dehydrogenase activity. Significant differences were found between sex in interscapular fat (P < 0.05) for CBX, in perirenal (P < 0.01) and interscapular (P < 0.05) fat for ME, and a tendency (P = 0.070) in liver for glucose-6-phosphate dehydrogenase. The oxidative stability of longissimus lumborum muscle was increased at the higher level of supplementation (P < 0.05). Conjugated linoleic acid reduced (P < 0.05) triglycerides and total cholesterol in plasma with a trend to increased serum leptin (P = 0.06). Plasma triglycerides were higher in males than females (P < 0.01) and plasma leptin tended to be higher in females (2.57 vs. 2.13 ng/ml, P = 0.06). It is concluded that dietary CLA reduced carcass fat in rabbits slaughtered at 2.8 kg or above and altered lipid metabolism to produce lower concentrations of serum triglycerides and total cholesterol and higher concentrations of leptin.
Published: 2002
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21. Borexino

Author: Gioacchino Ranucci, G. Alimonti, C. Arpesella, H.O. Beck, M. Balata, T. Beau, G. Bellini, J. Benziger, S. Bonetti, A. Brigatti, B. Caccianiga, L. Cadonati, F.P. Calaprice, G. Cecchet, M. Chen, A. De Bari, E. De Haas, O. Donghi, M. Deutsch, F. Elisei, A. Etenko, F. Von Feilitzsch, R. Fernholz, R. Ford, B. Freudiger, A. Garagiola, F. Gatti, S. Gazzana, M.G. Giammarchi, D. Giugni, A. Golubchikov, A. Goretti, C. Grieb, C. Hagner, T. Hagner, W. Hampel, E. Harding, F.X. Hartmann, R. von Hentig, H. Hess, G. Heusser, A. Ianni, P. Inzani, H. De Kerret, S. Kidner, J. Kiko, T. Kirsten, G. Korga, G. Korschinek, D. Kryn, V. Lagomarsino, M. Laubenstein, F. Loeser, P. Lombardi, S. Magni, S. Malvezzi, J. Maneira, I. Manno, G. Manuzio, F. Masetti, U. Mazzucato, E. Meroni, P. Musico, H. Neder, M. Neff, S. Nisi, L. Oberauer, M. Obolensky, M. Pallavicini, L. Papp, L. Perasso, A. Pocar, R.S. Raghavan, G. Ranucci, W. Rau, A. Razeto, E. Resconi, T. Riedel, A. Sabelnikov, P. Saggese, C. Salvo, R. Scardaoni, S. Schnert, K.H. Schuubeck, H. Seidel, T. Shutt, A. Sonnenschein, O. Smirnov, A. Sotnikov, M. Skorokhvatov, S. Sukhotin, R. Tartaglia, G. Testera, R.B. Vogelaar, S. Vitale, M. Woijcik, O. Zaimidoroga, and Y. Zakharov
Subjects: Nuclear and High Energy Physics, Atomic and Molecular Physics, and Optics
Published: 2001
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22. CMS technical design report, volume II: Physics performance

Author: G. L. BAYATIAN, S. CHATRCHYAN, G. HMAYAKYAN, A. M. SIRUNYAN, W. ADAM, T. BERGAUER, M. DRAGICEVIC, J. ERO, M. FRIEDL, R. FRUEHWIRTH, V. GHETE, P. GLASER, J. HRUBEC, M. JEITLER, M. KRAMMER, I. MAGRANS, I. MIKULEC, W. MITAROFF, T. NOEBAUER, M. PERNICKA, P. PORTH, H. ROHRINGER, J. STRAUSS, A. TAUROK, W. WALTENBERGER, G. WALZEL, E. WIDL, C. E. WULZ, A. FEDOROV, M. KORZHIK, O. MISSEVITCH, R. ZUYEUSKI, V. CHEKHOVSKY, O. DVORNIKOV, I. EMELIANTCHIK, A. LITOMIN, V. MOSSOLOV, N. SHUMEIKO, A. SOLIN, R. STEFANOVITCH, J. SUAREZ GONZALEZ, A. TIKHONOV, V. PETROV, J. D'HONDT, S. DE WEIRDT, R. GOORENS, J. HEYNINCK, S. LOWETTE, S. TAVERNIER, W. VAN DONINCK, L. VAN LANCKER, O. BOUHALI, B. CLERBAUX, G. DE LENTDECKER, J. P. DEWULF, T. MAHMOUD, P. E. MARAGE, L. NEUKERMANS, V. SUNDARARAJAN, C. VANDER VELDE, P. VANLAER, J. WICKENS, S. ASSOUAK, J. L. BONNET, G. BRUNO, J. CAUDRON, B. DE CALLATAY, J. DE FAVEREAU DE JENERET, S. DE VISSCHER, C. DELAERE, P. DEMIN, D. FAVART, E. FELTRIN, E. FORTON, G. GREGOIRE, S. KALININ, D. KCIRA, T. KEUTGEN, G. LEIBENGUTH, V. LEMAITRE, Y. LIU, D. MICHOTTE, O. MILITARU, A. NINANE, S. OVYN, T. PIERZCHALA, K. PIOTRZKOWSKI, V. ROBERFROID, X. ROUBY, D. TEYSSIER, O. VAN DER AA, M. VANDER DONCKT, E. DAUBIE, P. HERQUET, A. MOLLET, A. ROMEYER, W. BEAUMONT, M. CARDACI, E. DE LANGHE, E. A. DE WOLF, L. RURUA, M. H. G. SOUZA, V. OGURI, A. SANTORO, A. SZNAJDER, M. VAZ, E. M. GREGORES, S. F. NOVAES, T. ANGUELOV, G. ANTCHEV, I. ATANASOV, J. DAMGOV, N. DARMENOV, L. DIMITROV, V. GENCHEV, P. IAYDJIEV, B. PANEV, S. PIPEROV, S. STOYKOVA, G. SULTANOV, I. VANKOV, A. DIMITROV, V. KOZHUHAROV, L. LITOV, M. MAKARIEV, A. MARINOV, E. MARINOVA, S. MARKOV, M. MATEEV, B. PAVLOV, P. PETKOV, C. SABEV, S. STOYNEV, Z. TOTEVA, V. VERGUILOV, G. M. CHEN, H. S. CHEN, K. L. HE, C. H. JIANG, W. G. LI, H. M. LIU, X. MENG, X. Y. SHEN, H. S. SUN, M. YANG, W. R. ZHAO, H. L. ZHUANG, Y. BAN, J. CAI, S. LIU, S. J. QIAN, Z. C. YANG, Y. L. YE, J. YING, J. WU, Z. P. ZHANG, N. GODINOVIC, I. PULJAK, I. SORIC, Z. ANTUNOVIC, M. DZELALIJA, K. MARASOVIC, V. BRIGLJEVIC, D. FERENCEK, K. KADIJA, S. MOROVIC, M. PLANINIC, C. NICOLAOU, A. PAPADAKIS, P. A. RAZIS, D. TSIAKKOURI, A. HEKTOR, M. KADASTIK, K. KANNIKE, E. LIPPMAA, M. MUNTEL, M. RAIDAL, P. A. AARNIO, S. CZELLAR, E. HAEGGSTROEM, A. HEIKKINEN, J. HARKONEN, V. KARIMAKI, R. KINNUNEN, T. LAMPEN, K. LASSILA PERINI, S. LEHTI, T. LINDEN, P. R. LUUKKA, S. MICHAL, T. MAENPAA, J. NYSTEN, M. STETTLER, E. TUOMINEN, J. TUOMINIEMI, L. WENDLAND, T. TUUVA, J. P. GUILLAUD, P. NEDELEC, D. SILLOU, M. ANFREVILLE, S. BEAUCERON, E. BOUGAMONT, P. BREDY, R. CHIPAUX, M. DEJARDIN, D. DENEGRI, J. DESCAMPS, B. FABBRO, J. L. FAURE, S. GANJOUR, F. X. GENTIT, A. GIVERNAUD, P. GRAS, G. HAMEL DE MONCHENAULT, P. JARRY, F. KIRCHER, M. C. LEMAIRE, B. LEVESY, E. LOCCI, J. P. LOTTIN, I. MANDJAVIDZE, M. MUR, E. PASQUETTO, A. PAYN, J. RANDER, J. M. REYMOND, F. RONDEAUX, A. ROSOWSKY, Z. H. SUN, P. VERRECCHIA, S. BAFFIONI, F. BEAUDETTE, M. BERCHER, U. BERTHON, S. BIMBOT, J. BOUROTTE, P. BUSSON, M. CERUTTI, D. CHAMONT, C. CHARLOT, C. COLLARD, D. DECOTIGNY, E. DELMEIRE, L. DOBRZYNSKI, A. M. GAILLAC, Y. GEEREBAERT, J. GILLY, M. HAGUENAUER, A. KARAR, A. MATHIEU, G. MILLERET, P. MINE, P. PAGANINI, T. ROMANTEAU, I. SEMENIOUK, Y. SIROIS, J. D. BERST, J. M. BROM, F. DIDIERJEAN, F. DROUHIN, J. C. FONTAINE, U. GOERLACH, P. GRAEHLING, L. GROSS, L. HOUCHU, P. JUILLOT, A. LOUNIS, C. MAAZOUZI, D. MANGEOL, C. OLIVETTO, T. TODOROV, P. VAN HOVE, D. VINTACHE, M. AGERON, J. L. AGRAM, G. BAULIEU, M. BEDJIDIAN, J. BLAHA, A. BONNEVAUX, G. BOUDOUL, E. CHABANAT, C. COMBARET, D. CONTARDO, R. DELLA NEGRA, P. DEPASSE, T. DUPASQUIER, H. EL MAMOUNI, N. ESTRE, J. FAY, S. GASCON, N. GIRAUD, C. GIRERD, R. HAROUTUNIAN, J. C. IANIGRO, B. ILLE, M. LETHUILLIER, N. LUMB, H. MATHEZ, G. MAURELLI, L. MIRABITO, S. PERRIES, O. RAVAT, R. KVATADZE, V. ROINISHVILI, R. ADOLPHI, R. BRAUER, W. BRAUNSCHWEIG, H. ESSER, L. FELD, A. HEISTER, W. KARPINSKI, K. KLEIN, C. KUKULIES, J. OLZEM, A. 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SCHEURER, D. SCHIEFERDECKER, A. SCHMIDT, H. J. SIMONIS, A. THEEL, A. VEST, T. WEILER, C. WEISER, J. WENG, V. ZHUKOV, G. KARAPOSTOLI, P. KATSAS, P. KREUZER, A. PANAGIOTOU, C. PAPADIMITROPOULOS, G. ANAGNOSTOU, M. BARONE, T. GERALIS, C. KALFAS, A. KOIMAS, A. KYRIAKIS, S. KYRIAZOPOULOU, D. LOUKAS, A. MARKOU, C. MARKOU, C. MAVROMMATIS, K. THEOFILATOS, G. VERMISOGLOU, A. ZACHARIADOU, X. ASLANOGLOU, I. EVANGELOU, P. KOKKAS, N. MANTHOS, I. PAPADOPOULOS, G. SIDIROPOULOS, F. A. TRIANTIS, G. BENCZE, L. BOLDIZSAR, C. HAJDU, D. HORVATH, A. LASZLO, G. ODOR, F. SIKLER, N. TOTH, G. VESZTERGOMBI, P. ZALAN, J. MOLNAR, N. BENI, A. KAPUSI, G. MARIAN, P. RAICS, Z. SZABO, Z. SZILLASI, G. ZILIZ, H. S. BAWA, S. B. BERI, V. BHANDARI, V. BHATNAGAR, M. KAUR, R. KAUR, J. M. KOHLI, A. KUMAR, J. B. SINGH, A. BHARDWAJ, S. BHATTACHARYA, S. CHATTERJI, S. CHAUHAN, B. C. CHOUDHARY, P. GUPTA, M. JHA, K. RANJAN, R. K. SHIVPURI, A. K. SRIVASTAVA, S. BORKAR, M. DIXIT, M. GHODGAONKAR, S. K. KATARIA, S. K. LALWANI, V. 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WIJNANT, M. WILHELMSSON, I.M. WILLERS, W. BERTL, K. DEITERS, W. ERDMANN, K. GABATHULER, S. HEISING, R. HORISBERGER, Q. INGRAM, H.C. KAESTLI, D. KOTLINSKI, S. KONIG, D. RENKER, T. ROHE, M. SPIRA, B. BETEV, G. DAVATZ, G. DISSERTORI, M. DITTMAR, L. DJAMBAZOV, J. EHLERS, R. EICHLER, G. FABER, K. FREUDENREICH, J.F. FUCHS, C. GRAB, A. HOLZNER, P. INGENITO, U. LANGENEGGER, P. LECOMTE, G. LESHEV, A. LISTER, P.D. LUCKEY, W. LUSTERMANN, J.D. MAILLEFAUD, F. MOORTGAT, A. NARDULLI, F. NESSI-TEDALDI, L. PAPE, F. PAUSS, H. RYKACZEWSKI, U. ROSER, D. SCHINZEL, A. STARODUMOV, F. STOCKLI, H. SUTER, L. TAUSCHER, P. TRUB, H.P. VON GUNTEN, M. WENSVEEN, E. ALAGOZ, C. AMSLER, V. CHIOCHIA, C. HOERMANN, K. PROKOFIEV, C. REGENFUS, P. ROBMANN, T. SPEER, S. STEINER, L. WILKE, S. BLYTH, Y.H. CHANG, E.A. CHEN, A. GO, C.C. HUNG, C.M. KUO, W. LIN, P. CHANG, Y. CHAO, K.F. CHEN, Z. GAO, Y. HSIUNG, Y.J. LEI, J. SCHUMANN, J.G. SHIU, K. UENO, Y. VELIKZHANIN, P. YEH, S. AYDIN, M.N. BAKIRCI, S. CERCI, I. DUMANOGLU, S. ERTURK, S. ESEN, E. ESKUT, A. KAYIS TOPAKSU, P. KURT, H. OZKURT, A. POLATOZ, K. SOGUT, H. TOPAKLI, M. VERGILI, T. YETKIN, G. ONENGUT, H. GAMSIZKAN, C. OZKAN, S. SEKMEN, M. SERIN-ZEYREK, R. SEVER, E. YAZGAN, M. ZEYREK, A. CAKIR, K. CANKOCAK, M. DELIOMEROGLU, D. DEMIR, K. DINDAR, E. GULMEZ, E. ISIKSAL, M. KAYA, O. KAYA, S. OZKORUCUKLU, N. SONMEZ, B. GRINEV, V. LYUBYNSKIY, V. SENCHYSHYN, L. LEVCHUK, P. SOROKIN, D.S. BAILEY, T. BARRASS, J.J. BROOKE, R. CROFT, D. CUSSANS, D. EVANS, R. FRAZIER, N. GRANT, G.P. HEATH, H.F. HEATH, B. HUCKVALE, C. LYNCH, C.K. MACKAY, S. METSON, D.M. NEWBOLD, V.J. SMITH, R.J. TAPPER, S.A. BAIRD, K.W. BELL, R.M. BROWN, D.J.A. COCKERILL, J.A. COUGHLAN, P.S. FLOWER, V.B. FRANCIS, M. FRENCH, J. GREENHALGH, R. HALSALL, J. HILL, L. JONES, B.W. KENNEDY, L. LINTERN, A.B. LODGE, J. MADDOX, Q. MORRISSEY, P. MURRAY, M. PEARSON, S. QUINTON, J. SALISBURY, A. SHAH, C. SHEPHERD-THEMISTOCLEOUS, B. SMITH, M. SPROSTON, R. STEPHENSON, S. TAGHAVIRAD, I.R. TOMALIN, J.H. WILLIAMS, F. ARTECHE, R. BAINBRIDGE, G. BARBER, P. BARRILLON, R. BEUSELINCK, F. BLEKMAN, D. BRITTON, D. COLLING, G. DASKALAKIS, G. DEWHIRST, S. DRIS, C. FOUDAS, J. FULCHER, S. GREDER, G. HALL, J. JONES, J. LEAVER, B.C. MACEVOY, O. MARONEY, A. NIKITENKO, A. PAPAGEORGIOU, D.M. RAYMOND, M.J. RYAN, C. SEEZ, P. SHARP, M. TAKAHASHI, C. TIMLIN, T. VIRDEE, S. WAKEFIELD, M. WINGHAM, A. ZABI, Y. ZHANG, O. ZORBA, C. DA VIA, I. GOITOM, P.R. HOBSON, P. KYBERD, C. MUNRO, J. NEBRENSKY, I. REID, O. SHARIF, R. TAYLOR, L. TEODORESCU, S.J. WATTS, I. YASELLI, E. HAZEN, A.H. HEERING, D. LAZIC, E. MACHADO, D. OSBORNE, J. ROHLF, L. SULAK, F. VARELA RODRIGUEZ, S. WU, D. CUTTS, R. HOOPER, G. LANDSBERG, R. PARTRIDGE, S. VANINI, R. BREEDON, M. CASE, M. CHERTOK, J. CONWAY, P.T. COX, R. ERBACHER, J. GUNION, B. HOLBROOK, W. KO, R. LANDER, D. PELLETT, J. SMITH, A. SOHA, M. TRIPATHI, R. VOGT, V. ANDREEV, K. ARISAKA, D. CLINE, R. COUSINS, S. ERHAN, M. FELCINI, J. HAUSER, M. IGNATENKO, B. LISOWSKI, D. MATLOCK, C. MATTHEY, B. MOHR, J. MUMFORD, S. OTWINOWSKI, G. RAKNESS, P. SCHLEIN, Y. SHI, J. TUCKER, V. VALUEV, R. WALLNY, H.G. WANG, X. YANG, Y. ZHENG, R. CLARE, D. FORTIN, D. FUTYAN, J.W. GARY, M. GIUNTA, G. HANSON, G.Y. JENG, S.C. KAO, H. LIU, G. PASZTOR, A. SATPATHY, B.C. SHEN, R. STRINGER, V. SYTNIK, R. WILKEN, D. ZER-ZION, J.G. BRANSON, E. DUSINBERRE, J. LETTS, T. MARTIN, M. MOJAVER, H.P. PAAR, H. PI, M. PIERI, A. RANA, V. SHARMA, A. WHITE, F. WURTHWEIN, A. AFFOLDER, C. CAMPAGNARI, C. HILL, J. INCANDELA, S. KYRE, J. LAMB, J. RICHMAN, D. STUART, D. WHITE, J. ALBERT, A. BORNHEIM, J. BUNN, J. CHEN, G. DENIS, P. GALVEZ, M. GATAULLIN, I. LEGRAND, V. LITVINE, Y. MA, D. NAE, H.B. NEWMAN, S. RAVOT, S. SHEVCHENKO, S. SINGH, C. STEENBERG, X. SU, V. TIMCIUC, F. VAN LINGEN, J. VEVERKA, B.R. VOICU, A. WEINSTEIN, R. WILKINSON, Y. YANG, L.Y. ZHANG, K. ZHU, R.Y. ZHU, T. FERGUSON, M. PAULINI, J. RUSS, N. TERENTYEV, H. VOGEL, I. VOROBIEV, J.P. CUMALAT, W.T. FORD, D. JOHNSON, U. NAUENBERG, K. STENSON, S.R. WAGNER, J. ALEXANDER, D. CASSEL, K. ECKLUND, B. HELTSLEY, C.D. JONES, V. KUZNETSOV, J.R. PATTERSON, A. RYD, J. THOM, P. WITTICH, C.P. BEETZ, G. CIRINO, V. PODRASKY, C. SANZENI, D. WINN, S. ABDULLIN, M.A. AFAQ, M. ALBROW, J. AMUNDSON, G. APOLLINARI, M. ATAC, W. BADGETT, J.A. BAKKEN, B. BALDIN, L.A.T. BAUERDICK, A. BAUMBAUGH, U. BAUR, P.C. BHAT, F. BORCHERDING, K. BURKETT, J.N. BUTLER, H. CHEUNG, I. CHURIN, S. CIHANGIR, M. DEMARTEAU, D.P. EARTLY, J.E. ELIAS, V.D. ELVIRA, I. FISK, J. FREEMAN, P. GARTUNG, F.J.M. GEURTS, D.A. GLENZINSKI, E. GOTTSCHALK, G. GRAHAM, D. GREEN, G.M. GUGLIELMO, Y. GUO, O. GUTSCHE, A. HAHN, J. HANLON, S. HANSEN, R.M. HARRIS, T. HESSELROTH, S.L. HOLM, B. HOLZMAN, S. IQBAL, E. JAMES, M. JOHNSON, U. JOSHI, B. KLIMA, J. KOWALKOWSKI, T. KRAMER, S. KWAN, E. LA VALLIE, M. LARWILL, S. LOS, L. LUEKING, G. LUKHANIN, S. LUSIN, K. MAESHIMA, P. MCBRIDE, S.J. MURRAY, V. O'DELL, M. PATERNO, J. PATRICK, D. PETRAVICK, R. PORDES, O. PROKOFYEV, V. RASMISLOVICH, N. RATNIKOVA, A. RONZHIN, V. SEKHRI, E. SEXTON-KENNEDY, T. SHAW, D. SKOW, R.P. SMITH, W.J. SPALDING, L. SPIEGEL, M. STAVRIANAKOU, G. STIEHR, I. SUZUKI, P. TAN, W. TANENBAUM, S. TKACZYK, S. VESELI, R. VIDAL, H. WENZEL, J. WHITMORE, W.J. WOMERSLEY, W.M. WU, Y. WU, A. YAGIL, J. YARBA, J.C. YUN, D. ACOSTA, P. AVERY, V. BARASHKO, P. BARTALINI, D. BOURILKOV, R. CAVANAUGH, A. DROZDETSKIY, R.D. FIELD, Y. FU, L. GRAY, D. HOLMES, B.J. KIM, S. KLIMENKO, J. KONIGSBERG, A. KORYTOV, K. KOTOV, P. LEVCHENKO, A. MADORSKY, K. MATCHEV, GUENAKH MITSELMAKHER, Y. PAKHOTIN, C. PRESCOTT, P. RAMOND, J.L. RODRIGUEZ, M. SCHMITT, B. SCURLOCK, H. STOECK, J. YELTON, W. BOEGLIN, V. GAULTNEY, L. KRAMER, S. LINN, P. MARKOWITZ, G. MARTINEZ, B. RAUE, J. REINHOLD, A. ASKEW, M. BERTOLDI, W.G.D. DHARMARATNA, Y. GERSHTEIN, S. HAGOPIAN, V. HAGOPIAN, M. JENKINS, K.F. JOHNSON, H. PROSPER, H. WAHL, M. BAARMAND, L. BAKSAY, S. GURAGAIN, M. HOHLMANN, H. MERMERKAYA, R. RALICH, I. VODOPIYANOV, M.R. ADAMS, R.R. BETTS, C.E. GERBER, E. SHABALINA, C. SMITH, T. TEN, U. AKGUN, A.S. AYAN, A. COOPER, P. DEBBINS, F. DURU, M. FOUNTAIN, N. GEORGE, E. MCCLIMENT, J.P. MERLO, A. MESTVIRISHVILI, M.J. MILLER, C.R. NEWSOM, E. NORBECK, Y. ONEL, I. SCHMIDT, S. WANG, E.W. ANDERSON, O. ATRAMENTOV, J.M. HAUPTMAN, J. LAMSA, B.A. BARNETT, B. BLUMENFELD, C.Y. CHIEN, D.W. KIM, P. MAKSIMOVIC, S. SPANGLER, M. SWARTZ, P. BARINGER, A. BEAN, D. COPPAGE, O. GRACHOV, E.J. KIM, M. MURRAY, D. BANDURIN, T. BOLTON, A. KHANOV, Y. MARAVIN, D. ONOPRIENKO, F. RIZATDINOVA, R. SIDWELL, N. STANTON, E. VON TOERNE, D. BADEN, R. BARD, S.C. ENO, T. GRASSI, N.J. HADLEY, R.G. KELLOGG, S. KUNORI, F. RATNIKOV, A. SKUJA, R. ARCIDIACONO, M. BALLINTIJN, G. BAUER, P. HARRIS, I. KRAVCHENKO, C. LOIZIDES, S. NAHN, C. PAUS, S. PAVLON, C. ROLAND, G. ROLAND, K. SUMOROK, S. VAURYNOVICH, G. VERES, B. WYSLOUCH, D. BAILLEUX, S. CORUM, P. CUSHMAN, A. DE BENEDETTI, A. DOLGOPOLOV, R. EGELAND, G. FRANZONI, W.J. GILBERT, J. GRAHL, J. HAUPT, Y. KUBOTA, J. MANS, N. PEARSON, R. RUSACK, A. SINGOVSKY, L.M. CREMALDI, R. GODANG, R. KROEGER, D.A. SANDERS, D. SUMMERS, K. BLOOM, D.R. CLAES, A. DOMINGUEZ, M. EADS, C. LUNDSTEDT, S. MALIK, G.R. SNOW, A. SOBOL, I. IASHVILI, A. KHARCHILAVA, G. ALVERSON, E. BARBERIS, O. BOERIU, G. EULISSE, Y. MUSIENKO, S. MUZAFFAR, I. OSBORNE, S. REUCROFT, J. SWAIN, L. TAYLOR, L. TUURA, D. WOOD, B. GOBBI, M. KUBANTSEV, H. SCHELLMAN, E. SPENCER, M. VELASCO, B. BAUMBAUGH, N.M. CASON, M. HILDRETH, D.J. KARMGARD, N. MARINELLI, R. RUCHTI, J. WARCHOL, M. WAYNE, B. BYLSMA, L.S. DURKIN, J. GILMORE, J. GU, D. HERMAN, P. KILLEWALD, K. KNOBBE, T.Y. LING, P. ELMER, D. MARLOW, P. PIROUE, D. STICKLAND, C. TULLY, T. WILDISH, S. WYNHOFF, Z. XIE, A. APRESYAN, K. ARNDT, K. BANICZ, V.E. BARNES, G. BOLLA, D. BORTOLETTO, A. BUJAK, A.F. GARFINKEL, O. GONZALEZ LOPEZ, L. GUTAY, N. IPPOLITO, Y. KOZHEVNIKOV, A.T. LAASANEN, C. LIU, V. MAROUSSOV, P. MERKEL, D.H. MILLER, J. MIYAMOTO, N. NEUMEISTER, C. ROTT, A. ROY, A. SEDOV, I. SHIPSEY, N. PARASHAR, G. EPPLEY, S.J. LEE, J. LIU, M. MATVEEV, T. NUSSBAUM, B.P. PADLEY, J. ROBERTS, A. TUMANOV, P. YEPES, A. BODEK, H. BUDD, Y.S. CHUNG, P. DE BARBARO, R. DEMINA, R. EUSEBI, G. GINTHER, Y. GOTRA, A. HOCKER, U. HUSEMANN, S. KORJENEVSKI, W. SAKUMOTO, P. SLATTERY, P. TIPTON, M. ZIELINSKI, E. BARTZ, J. DOROSHENKO, E. HALKIADAKIS, P.F. JACQUES, M.S. KALELKAR, D. KHITS, A. LATH, A. MACPHERSON, L. PERERA, R. PLANO, K. ROSE, S. SCHNETZER, S. SOMALWAR, R. STONE, G. THOMSON, T.L. WATTS, N. AKCHURIN, K.W. CARRELL, K. GUMUS, C. JEONG, H. KIM, V. PAPADIMITRIOU, A. SILL, M. SPEZZIGA, E. WASHINGTON, R. WIGMANS, L. ZHANG, T. BAPTY, D. ENGH, W. JOHNS, T. KESKINPALA, E. LUIGGI LOPEZ, S. NEEMA, S. NORDSTROM, S. PATHAK, P. SHELDON, E.W. VAANDERING, M. WEBSTER, M.W. ARENTON, S. CONETTI, B. COX, R. HIROSKY, R. IMLAY, A. LEDOVSKOY, D. PHILLIPS, H. POWELL, M. RONQUEST, D. SMITH, Y.W. BAEK, J.N. BELLINGER, D. BRADLEY, D. CARLSMITH, I. CROTTY, S. DASU, F. FEYZI, T. GORSKI, M. GROTHE, W. HOGG, M. JAWORSKI, P. KLABBERS, A. LANARO, R. LOVELESS, M. MAGRANS DE ABRIL, D. REEDER, W.H. SMITH, D. WENMAN, G.S. ATOYAN, S. DHAWAN, V. ISSAKOV, H. NEAL, A. POBLAGUEV, M.E. ZELLER, and B.S. YULDASHEV
Subjects: High Energy Physics::Phenomenology, STANDARD MODEL, High Energy Physics::Experiment, EXTRA DIMENSIONS, LHC, SUPERSYMMETRY, HIGGS
Abstract: CMS is a general purpose experiment, designed to study the physics of pp collisions at 14 TeV at the Large Hadron Collider (LHC). It currently involves more than 2000 physicists from more than 150 institutes and 37 countries. The LHC will provide extraordinary opportunities for particle physics based on its unprecedented collision energy and luminosity when it begins operation in 2007. The principal aim of this report is to present the strategy of CMS to explore the rich physics programme offered by the LHC. This volume demonstrates the physics capability of the CMS experiment. The prime goals of CMS are to explore physics at the TeV scale and to study the mechanism of electroweak symmetry breaking—through the discovery of the Higgs particle or otherwise. To carry out this task, CMS must be prepared to search for new particles, such as the Higgs boson or supersymmetric partners of the Standard Model particles, from the start-up of the LHC since new physics at the TeV scale may manifest itself with modest data samples of the order of a few fb-1 or less. The analysis tools that have been developed are applied to study in great detail and with all the methodology of performing an analysis on CMS data specific benchmark processes upon which to gauge the performance of CMS. These processes cover several Higgs boson decay channels, the production and decay of new particles such as Z' and supersymmetric particles, Bs production and processes in heavy ion collisions. The simulation of these benchmark processes includes subtle effects such as possible detector miscalibration and misalignment. Besides these benchmark processes, the physics reach of CMS is studied for a large number of signatures arising in the Standard Model and also in theories beyond the Standard Model for integrated luminosities ranging from 1 fb-1 to 30 fb-1. The Standard Model processes include QCD, B-physics, diffraction, detailed studies of the top quark properties, and electroweak physics topics such as the W and Z0 boson properties. The production and decay of the Higgs particle is studied for many observable decays, and the precision with which the Higgs boson properties can be derived is determined. About ten different supersymmetry benchmark points are analysed using full simulation. The CMS discovery reach is evaluated in the SUSY parameter space covering a large variety of decay signatures. Furthermore, the discovery reach for a plethora of alternative models for new physics is explored, notably extra dimensions, new vector boson high mass states, little Higgs models, technicolour and others. Methods to discriminate between models have been investigated. This report is organized as follows. Chapter 1, the Introduction, describes the context of this document. Chapters 2–6 describe examples of full analyses, with photons, electrons, muons, jets, missing ET, B-mesons and τ's, and for quarkonia in heavy ion collisions. Chapters 7–15 describe the physics reach for Standard Model processes, Higgs discovery and searches for new physics beyond the Standard Model.
Published: 2007

23. Performances of the CTF experiment in prospect of Borexino

Author: Gioacchino Ranucci, G. Alimonti, G. Anghloher, C. Arpesella, M. Balata, G. Bellini, J. Benziger, S. Bonetti, A. Brigatti, L. Cadonati, F.P. Calaprice, G. Cecchet, M. Chen, N. Darnton, A. de Bari, M. Deutsch, R. Dossi, F. Elisei, F. von Feilitzsch, C. Galbiati, A. Garagiola, F. Gatti, M.G. Giammarchi, D. Giugni, T. Goldbrunner, A. Golubchikov, A. Goretti, T. Hagner, F. Hartmann, R. von Hentig, G. Heusser, A. Ianni, J. Jochum, M. Johnson, G. Korga, M. Laubenstein, F. Loeser, P. Lombardi, S. Magni, S. Malvezzi, I. Manno, G. Manuzio, F. Masetti, U. Mazzucato, E. Meroni, M. Neff, S. Nisi, A. Nostro, L. Oberauer, A. Perotti, P. Raghavan, R.S. Raghavan, G. Ranucci, E. Resconi, M. Ruscitti, F. Sacchetti, R. Scardaoni, S. Schönert, O. Smirnov, A. Sotnikov, R. Tartaglia, G. Testera, B. Vogelaar, S. Vitale, M. Wojcik, and O. Zaimidoroga
Subjects: Physics, Nuclear and High Energy Physics, Physics::Instrumentation and Detectors, Solar neutrino, Liquid scintillation counting, Detector, Low activity, Full scale, Flux, Scintillator, Atomic and Molecular Physics, and Optics, Nuclear physics, High Energy Physics::Experiment, Borexino
Abstract: The crucial issue of the direct determination of the 7 Be solar neutrino flux will be addressed by the Borexino experiment, a real time, massive calorimetric liquid scintillation detector to be installed at the Gran Sasso Laboratory. The challenge of the extremely low radioactive level allowed in the scintillator for the feasibility of the measurement required the precise and sensitive evaluation of its radiopurity with a dedicated 5 tons prototype, the Counting Test Facility. The main experimental features of the CTF and its unprecedented results in the area of the low activity measurements are described in this paper, together with their implications in the design of the full scale experiment.
Published: 1999
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24. A neural network approach to spatial reconstruction in the CTF detector

Author: S. Magni and Gianluca Alimonti
Subjects: Physics, Nuclear and High Energy Physics, Scale (ratio), Artificial neural network, Physics::Instrumentation and Detectors, business.industry, Detector, Information processing, Scalar (physics), Volume (computing), Pattern recognition, Physical information, Artificial intelligence, business, Instrumentation, Borexino
Abstract: Artificial neural networks may in some cases present a new important approach to information processing. We have investigated whether the accuracy offered by this technique is good enough to extract physical information from the signals coming from an unsegmented large volume liquid scintillator detector. In particular, we wanted to understand whether this method is well suited to be implemented in the Borexino detector for monitoring or for on-line event selection purposes. The results obtained on data from a smaller scale Borexino-like detector, implementing a neural network algorithm on a sequential scalar computer, have been compared to those of a standard best-fit procedure.
Published: 1998
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25. Measurement of the 14C abundance in a low-background liquid scintillator

Author: R. B. Vogelaar, Ugo Mazzucato, S. Magni, G. Bellini, S. Schönert, M. Deutsch, Fausto Elisei, G. Heusser, Stefano Bonetti, A. Golubchikov, Lothar Oberauer, Sandra Malvezzi, O. Smirnov, Gioacchino Ranucci, M. Ruscitti, R. S. Raghavan, N. Darnton, Matthias Laubenstein, Flavio Gatti, M. Johnson, A. de Bari, R. Tartaglia, I. Manno, F. von Feilitzsch, E. Meroni, Laura Cadonati, G. Cecchet, G. Angloher, G. Manuzio, G. Testera, D. Giugni, A. Perotti, R. von Hentig, J. Jochum, M. Neff, Frank Calaprice, G. Alimonti, A. Ianni, R. Scardaoni, C. Arpesella, Fausto Masetti, T. Hagner, A. Nostro, O. Zaimidoroga, A. Goretti, M. Balata, T. Goldbrunner, Cristiano Galbiati, S. Vitale, Elisa Resconi, F. X. Hartmann, Marco Giammarchi, Paolo Lombardi, A. Preda, P. Ullucci, M. L. Chen, and Jay Burton Benziger
Subjects: Nuclear physics, Physics, Nuclear and High Energy Physics, Physics::Instrumentation and Detectors, Abundance (chemistry), Solar neutrino, Liquid scintillation counting, Detector, Flux, High Energy Physics::Experiment, Neutrino, Scintillator, Spectroscopy
Abstract: The 14 C/ 12 C ratio in 4.8 m 3 of high-purity liquid scintillator was measured at (1.94±0.09)×10 −18 , the lowest 14 C abundance ever measured. At this level the spectroscopy of low-energy solar neutrinos, in particular a measurement of the 7 Be neutrino flux, will not be obstructed by the 14 C β decay intrinsic to a liquid scintillator detector. A comprehensive study of the deviation of the shape of the 14 C β spectrum from the allowed statistical shape reveals consistent results with recent observations and calculations. Possible origins of the 14 C in the liquid scintillator are discussed.
Published: 1998
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26. Prima indagine sullo stato delle superfici inerbite in Italia

Author: A. REYNERI, G. BRUNO, P. MARTINIELLO, E. D'ANDREA, T. MAGGIORE, A. VIGONI, U. ZILIOTTO, S. MACOLINO, M. VOLTERRANI, S. MAGNI, CF CERETI, F. ROSSINI, LETO, Claudio, LA BELLA, Salvatore, A REYNERI, G BRUNO, P MARTINIELLO, E D'ANDREA, T MAGGIORE, A VIGONI, LETO C, S LA BELLA, U ZILIOTTO, S MACOLINO, M VOLTERRANI, S MAGNI, CF CERETI, and F ROSSINI
Published: 2004

27. No-reference pixel video quality monitoring of channel-induced distortion

Author: Marco Tagliasacchi, S. Magni, Giuseppe Valenzise, and Stefano Tubaro
Subjects: Theoretical computer science, Pixel, Channel (digital image), Computer science, Network packet, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, 020207 software engineering, Data_CODINGANDINFORMATIONTHEORY, 02 engineering and technology, Video quality, Distortion, 0202 electrical engineering, electronic engineering, information engineering, Media Technology, Maximum a posteriori estimation, 020201 artificial intelligence & image processing, Electrical and Electronic Engineering, Bitstream, Algorithm, Decoding methods
Abstract: Video transmitted over an error-prone network may be received at the decoder with degradations due to packet losses. No-reference quality monitoring algorithms are the most practical way to measure the quality of the received video, since they do not impose any change with respect to the network architecture. Conventionally, these methods assume the availability of the corrupted bitstream. In some situations this is not possible, e.g., because the bitstream is encrypted or processed by third-party decoders, and only the decoded pixel values can be used. The major issue in this scenario is the lack of knowledge about which regions of the video have been actually lost, which is a fundamental ingredient for estimating channel-induced distortion. In this paper, we propose a maximum a posteriori estimation of the pattern of lost macroblocks, which assumes the knowledge of the decoded pixels only. This information can be used as input to a no-reference quality monitoring system, which produces an accurate estimate of the mean-square-error (MSE) distortion introduced by channel errors. The results of the proposed method are well correlated with the MSE distortion computed in full-reference mode, with a linear correlation coefficient equal to 0.9 at frame level and 0.98 at sequence level.
Published: 2012
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28. Radiation tolerance of the CMS forward pixel detector

Author: S. Taroni, S. Sala, Ping Tan, S. Magni, Alan D. Lopez, M. Turqueti, A. Florez, G.B. Cerati, Mauro Emanuele Dinardo, M. Rovere, S. Malvezzi, Dario Menasce, D. Pedrini, Lorenzo Uplegger, L. Moroni, C. R. Newsom, Simon Kwan, Cerati, G, Dinardo, M, Florez, A, Kwan, S, Lopez, A, Magni, S, Malvezzi, S, Menasce, D, Moroni, L, Newsom, C, Pedrini, D, Rovere, M, Sala, S, Tan, P, Taroni, S, Turqueti, M, and Uplegger, L
Subjects: Physics, Nuclear and High Energy Physics, medicine.medical_specialty, Silicon pixel detectors, Physics::Instrumentation and Detectors, business.industry, Physics::Medical Physics, Radiation dose, Radiation tolerance, Silicon pixel detector, Optics, Radiation tolerance, Maximum dose, medicine, Physics::Accelerator Physics, High Energy Physics::Experiment, Medical physics, Fermilab, Irradiation, business, Instrumentation, Beam (structure), Pixel detector
Abstract: In this paper we present some results on the radiation tolerance of the CMS forward pixel detector. They were obtained from a beam test at Fermilab of a pixel-detector module, which was previously irradiated up to a maximum dose of 45 Mrad of protons at 200 MeV. It is shown that CMS forward pixel detector can tolerate this radiation dose without any major deterioration of its performance. © 2008 Elsevier B.V.
Published: 2009

29. Surface and bulk modification of W-La2O3 armor mock-up

Author: Alberto Tagliaferri, F. Ghezzi, Giovanni Maria Vanacore, S. Magni, Maurizio Zani, Ghezzi, F, Zani, M, Magni, S, Vanacore, G, and Tagliaferri, A
Subjects: Nuclear and High Energy Physics, Scanning electron microscope, Chemistry, Analytical chemistry, W-La2O3 nanoparticle, Plasma, law.invention, surface vs bulk behavior, Nuclear Energy and Engineering, law, Mockup, Thermal, Microscopy, scanning Auger microscopy, General Materials Science, Profilometer, Electron microscope, Particle density
Abstract: W–(1%)La 2 O 3 has been investigated after thermal exposure in the Quasi-Stationary Plasma Accelerator facility in order to obtain information regarding its surface damage and morphological modification. The profilometry measurements and the Scanning Electron Microscopy analysis showed that surface erosion and corrugation become more pronounced with increasing the thermal load. The La 2 O 3 particle density inside the sample has been measured by Scanning Auger Microscopy. It decreases with increasing the thermal load and presents a negative gradient from the bulk to the surface.
Published: 2009
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30. Evaluation of the power of six clustering features in identifying a homogeneous disease subset in juvenile idiopathic arthritis (JIA)

Author: Alberto Martini, Silvia Pederzoli, E. Castell, N Ullmann, O Arguedas, Alessandra Magnani, A Pistorio, S Magni Manzoni, S.K. Oliveira, A Ravelli, and N Ruperto
Subjects: medicine.medical_specialty, Oligoarthritis, lcsh:Diseases of the musculoskeletal system, business.industry, lcsh:RJ1-570, Arthritis, lcsh:Pediatrics, Disease, medicine.disease, Rheumatology, Psoriatic arthritis, Homogeneous, Internal medicine, Pediatrics, Perinatology and Child Health, Poster Presentation, medicine, Physical therapy, Immunology and Allergy, Polyarthritis, Pediatrics, Perinatology, and Child Health, lcsh:RC925-935, Cluster analysis, business
Abstract: Methods All patients seen in study centers between 1983 and 2004 (N = 750) were classified according to ILAR criteria. Categories of systemic arthritis, RF-positive polyarthritis, and enthesitis related arthritis were excluded because it was felt they represent sufficiently homogeneous entities. Patients in the remaining categories (oligoarthritis persistent and extended, RF-negative polyarthritis, psoriatic arthritis and undifferentiated arthritis) were grouped together (N = 603). In each patient, the presence of the 6 clustering features was assessed. The relative power of each clustering feature in identifying a homogeneous disease subgroup was examined by assessing its ability to separate patients by the presence of the remaining clustering features. Results The ANA revealed the greatest power in separating patients with or without the other clustering features (see table 1), p < 0.01.
Published: 2008

31. Development and initial validation of the parent acceptable symptom state in juvenile idiopathic arthritis (JIA)

Author: Daniela Tani, A Ravelli, Benedetta Schiappapietra, N Ruperto, Stefano Lanni, Giovanni Filocamo, Alberto Martini, S Magni Manzoni, A Pistorio, Stefania Viola, and Nicoletta Solari
Subjects: medicine.medical_specialty, Percentile, Pediatrics, lcsh:Diseases of the musculoskeletal system, business.industry, lcsh:RJ1-570, Outcome measures, Arthritis, lcsh:Pediatrics, Stepwise regression, medicine.disease, Rheumatology, Quality of life, Internal medicine, Poster Presentation, Pediatrics, Perinatology and Child Health, medicine, Immunology and Allergy, Juvenile, Pediatrics, Perinatology, and Child Health, lcsh:RC925-935, Pediatric rheumatology, business
Abstract: Methods 369 parents completed a multidimensional questionnaire (the JAMAR), including Juvenile Arthritis Functionality Scale (JAFS) (score 0–30), Pediatric Rheumatology Quality of Life (PRQL) questionnaire (score 0–30) and traditional JIA outcome measures, and stated whether they considered their children's status satisfactory or not. PASS thresholds were estimated based on parent opinion and targeting the 75th percentile of cumulative distribution. Stepwise logistic regression was used to assess contributors to PASS. PASS was validated by analyzing proportions of patients who were judged by parent or physician in remission, flare or continued activity.
Published: 2008
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32. Surface Morphological Modifications of Divertor Tiles during ELM's mode

Author: a Ghezzi F.M., Zani b, S. Magni c, G.M. Vanacore b, and A. Tagliaferri b
Subjects: ____
Abstract: ___
Published: 2008

33. CMS physics technical design report, volume II: Physics performance

Author: G. Russo, R. Halsall, H. L. Zhuang, Stephan Linn, Stefanos Dris, J.F. Gunion, D. Delikaris, David Mark Raymond, Christophe Delaere, J. Caballero Bejar, Alex Kamenev, Victor Kim, Armando Lanaro, Sajjad Asghar, Vivek Sharma, P. Mereu, S. B. Kim, M. G. Albrow, Kostas Kloukinas, R. A. Kvatadze, Y. Velikzhanin, C. Mavrommatis, J. T. Rhee, M. Guerzoni, Robert M Harris, F. Romano, Daniele Spiga, Flera Rizatdinova, Dmitry Gorbunov, Giacomo Bruno, Laszlo Boldizsar, W. E. Johns, B. De Callatay, Pushpalatha C Bhat, M. Pioppi, Lawrence Sulak, L. J. Gutay, M. Hashemi, W. Badgett, A. Bartoloni, C. Y. Chien, E. Marinova, Daniel Robert Marlow, J. M. Barcala, C. Sabev, Roberto Sacchi, P. Bartalini, B. Panev, J. Reinhold, Yves Sirois, J. Ying, M. Demarteau, Alicia Calderon, Arno Heister, Lothar At Bauerdick, Marco Meschini, R. Wilkinson, Tejinder Virdee, Mirko Planinic, G. Martinelli, Y. Ershov, Piotr Traczyk, M. Ageron, Kirill Prokofiev, S. De Visscher, W. Bertl, Julia Thom, D. S. Bailey, N. Manna, Francesco Navarria, A. Karar, Pierre Ramond, Lucia Silvestris, R. Eichler, Neeti Parashar, S. Cucciarelli, R. Gokieli, Christopher George Tully, L. Masetti, I. Gonzalez Cabellero, Klaus Rabbertz, S. Zelepoukine, Sebastiano Albergo, A. Bonnevaux, P. Fabbricatore, Claudio Campagnari, V. Timciuc, O. Zorba, Igor Lokhtin, Ezio Maina, Colin Bernet, Nadia Pastrone, M. Galanti, K. Marasovic, Jim Kowalkowski, M. Zielinski, P. Aspell, Teppo Mäenpää, Pamela Klabbers, V. B. Francis, I. Diaz Merino, H. A. Sanchez Hernandez, Valery Zhukov, Christos Leonidopoulos, Gyorgy Bencze, Dimitri Bourilkov, Vassili Kachanov, Marina Passaseo, Patrick Slattery, J. Schümann, K. Cho, Hans-Christian Kaestli, Filip Moortgat, Francesca Nessi-Tedaldi, S. K. Lalwani, P. Trüb, D. Wenman, Aliaksandr Litomin, P. Siegrist, S. K. Oh, M. Kossov, A. Slav, Nicanor Colino, Z. Wlodarczyk, J. Amundson, H. Mathez, A. Papageorgiou, Pete Markowitz, J. Blocki, I. Soric, L. Stepanova, Pierluigi Paolucci, Amitabh Lath, Jianhong Wu, N. Sinanis, R. Imlay, Dario Menasce, T. Grassi, S. Lusin, H. von Gunten, T. Weiler, Gyorgy Vesztergombi, J. P. Dewulf, G. Marian, B. A. Barnett, N. Iyurin, Frank Jm Geurts, T. Hesselroth, Nikolaos Manthos, Martin Grunewald, Oleg Prokofyev, Wolfram Erdmann, V. Elsha, A. Krokhotin, Livio Fanò, David Barney, Stephanie Beauceron, Mark Raymond Adams, Nicolo Cartiglia, Alexander Oh, Safdar Abbas, Giorgio Apollinari, M. Jenkins, G. Belli, E. E. Boos, Elena Accomando, M. Afaq, Yan-Lin Ye, M. Serin-Zeyrek, Karl Gill, H. S. Chen, Roland Horisberger, S. Mersi, Serguei Ganjour, P. Tempesta, Sergio Cittolin, Julien Caudron, I. Schmidt, Stefan Schael, R. Dabrowski, Sudhir Malik, M. Cardenas Montes, P. S. Flower, K. Gabathuler, T. L. Watts, D. A. Sanders, V. Bhandari, G. Lukhanin, Y. Fu, S. Vassiliev, I. Legrand, Srecko Morovic, Francois Vasey, Yuan Chao, Y. Geerebaert, Michele Arneodo, Steve Reucroft, Boaz Klima, Richard G Kellogg, Pavel Demin, G. Schwering, V. Papadimitriou, Daijin Kim, Paolo Vitulo, William J Spalding, Jay Roberts, I. Pal, N. Estre, L. Tauscher, Andras Laszlo, S. Spangler, Darien Wood, H. Suter, Ia Iashvili, W. Tanenbaum, Yury Ivanov, Andre Sznajder, F. Rondeaux, S. Y. Jung, Yuri Gershtein, Monoranjan Guchait, Brajesh C Choudhary, Paul David Luckey, M. Sani, D. Lanske, N. Ilina, Ian Shipsey, J. G. Shiu, Artur Kalinowski, Igor Emeliantchik, B. Heltsley, Robin Erbacher, Henryk Czyrkowski, L. Rurua, R. Beuselinck, Umesh Joshi, Irina Vardanyan, David B. Cline, M. Hansen, P. Bordalo, Ariella Cattai, G. Gomezo, J. A. Bakken, Jordan Nash, Sung Keun Park, E. Luiggi Lopez, M. Wensveen, R. Folch, E. Carrone, Cristina Riccardi, D. Krpic, S. Magni, Nicholas John Hadley, Karl Matthew Ecklund, M. Stettler, S. Vanini, Andrey Vorobyev, Matteo Risoldi, J. Bourotte, Kati Lassila-Perini, A. De Benedetti, M. Aldaya Martin, M. Duda, A. Sadovski, K. Freudenreich, Javier Cuevas, Georgios Anagnostou, Melody A. Swartz, Maxwell Chertok, Danek Kotlinski, N. M. Cason, Carmen Albajar, Erhan Gülmez, S. C. Tonwar, Kaori Maeshima, Martin Erdmann, A. Oehler, G. Eulisse, V. Kozlov, Frank Hartmann, Luciano Orsini, Vasile Mihai Ghete, Giuseppe Bagliesi, A. Cyz, Harvey B Newman, Christof Roland, Y. S. Chung, V. V. Mitsyn, Roman Ryutin, E. Isiksal, L. Lueking, Petra Merkel, Pelin Kurt, S. Erhan, F. M. Farina, M. Cerutti, O.V. Dvornikov, V. Lysiakov, L. Barbone, V. Drollinger, Robert Stone, J. N. Butler, A. Kayis Topaksu, H. A. Salazar Ibarguen, Marcello Abbrescia, K. Datsko, J. Grahl, David Colling, M. Michelotto, Sergey Petrushanko, Patricia McBride, Krzysztof Doroba, Jorge Luis Rodriguez, Claire Shepherd-Themistocleous, Alan Sill, Z. Gao, Mikhail Korzhik, Paolo Lariccia, M. Letheren, Daniel Denegri, M. H.G. Souza, Vyacheslav Valuev, Thomas Ferguson, Alain Ninane, D. Phillips, Ren-Yuan Zhu, Pascal Vanlaer, Luciano Barone, C. 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Foeth, Belforte, S., Cossutti, F., DELLA RICCA, Giuseppe, Gobbo, B., Penzo, A., Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Département d'Astrophysique, de physique des Particules, de physique Nucléaire et de l'Instrumentation Associée (DAPNIA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Département Recherches Subatomiques (DRS-IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), informatique, Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), CMS, Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Laboratoire d'Annecy de Physique des Particules (LAPP), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Bayatian, G, Chatrchyan, S, Hmayakyan, G, Sirunyan, A, Adam, W, Bergauer, T, Dragicevic, M, Ero, J, Friedl, M, Fruehwirth, R, Ghete, V, Glaser, P, Hrubec, J, Jeitler, M, Krammer, M, Magrans, I, Mikulec, I, Mitaroff, W, Noebauer, T, Pernicka, M, Porth, P, Rohringer, H, Strauss, J, Taurok, A, Waltenberger, W, Walzel, G, Widl, E, Wulz, C, Fedorov, A, Korzhik, M, Missevitch, O, Zuyeuski, R, Chekhovsky, V, Dvornikov, O, Emeliantchik, I, Litomin, A, Mossolov, V, Shumeiko, N, Solin, A, Stefanovitch, R, Gonzalez, J, Tikhonov, A, Petrov, V, D'Hondt, J, De Weirdt, S, 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Stockli, F, Suter, H, Tauscher, L, Trub, P, Von Gunten, H, Wensveen, M, Alagoz, E, Amsler, C, Chiochia, V, Hoermann, C, Prokofiev, K, Regenfus, C, Robmann, P, Speer, T, Steiner, S, Wilke, L, Blyth, S, Chang, Y, Chen, E, Go, A, Hung, C, Kuo, C, Lin, W, Chang, P, Chao, Y, Chen, K, Gao, Z, Hsiung, Y, Lei, Y, Schumann, J, Shiu, J, Ueno, K, Velikzhanin, Y, Yeh, P, Aydin, S, Bakirci, M, Cerci, S, Dumanoglu, I, Erturk, S, Esen, S, Eskut, E, Topaksu, A, Kurt, P, Ozkurt, H, Polatoz, A, Sogut, K, Topakli, H, Vergili, M, Yetkin, T, Onengut, G, Gamsizkan, H, Ozkan, C, Sekmen, S, Serin Zeyrek, M, Sever, R, Yazgan, E, Zeyrek, M, Cakir, A, Cankocak, K, Deliomeroglu, M, Demir, D, Dindar, K, Gulmez, E, Isiksal, E, Kaya, M, Kaya, O, Ozkorucuklu, S, Sonmez, N, Grinev, B, Lyubynskiy, V, Senchyshyn, V, Levchuk, L, Sorokin, P, Bailey, D, Barrass, T, Brooke, J, Croft, R, Cussans, D, Evans, D, Frazier, R, Grant, N, Heath, G, Heath, H, Huckvale, B, Lynch, C, Mackay, C, Metson, S, Newbold, D, Smith, V, Tapper, R, Baird, S, Bell, K, Brown, R, Cockerill, D, Coughlan, J, Flower, P, Francis, V, French, M, Greenhalgh, J, Halsall, R, Hill, J, Jones, L, Kennedy, B, Lintern, L, Lodge, A, Maddox, J, Morrissey, Q, Murray, P, Pearson, M, Quinton, S, Salisbury, J, Shah, A, Shepherd Themistocleous, C, Smith, B, Sproston, M, Stephenson, R, Taghavirad, S, Tomalin, I, Arteche, F, Bainbridge, R, Barber, G, Barrillon, P, Beuselinck, R, Blekman, F, Britton, D, Colling, D, Daskalakis, G, Dewhirst, G, Dris, S, Foudas, C, Fulcher, J, Greder, S, Hall, G, Jones, J, Leaver, J, Macevoy, B, Maroney, O, Nikitenko, A, Papageorgiou, A, Raymond, D, Ryan, M, Seez, C, Sharp, P, Takahashi, M, Timlin, C, Virdee, T, Wakefield, S, Wingham, M, Zabi, A, Zhang, Y, Zorba, O, Da Via, C, Goitom, I, Hobson, P, Kyberd, P, Munro, C, Nebrensky, J, Reid, I, Sharif, O, Taylor, R, Teodorescu, L, Watts, S, Yaselli, I, Hazen, E, Heering, A, Lazic, D, Machado, E, Osborne, D, Rohlf, J, Sulak, L, Rodriguez, F, Wu, S, Cutts, D, Hooper, R, Landsberg, G, Partridge, R, Vanini, S, Breedon, R, Case, M, Chertok, M, Conway, J, Cox, P, Erbacher, R, Gunion, J, Holbrook, B, Ko, W, Lander, R, Pellett, D, Smith, J, Soha, A, Tripathi, M, Vogt, R, Andreev, V, Arisaka, K, Cline, D, Cousins, R, Erhan, S, Felcini, M, Hauser, J, Ignatenko, M, Lisowski, B, Matlock, D, Matthey, C, Mohr, B, Mumford, J, Otwinowski, S, Rakness, G, Schlein, P, Shi, Y, Tucker, J, Valuev, V, Wallny, R, Wang, H, Yang, X, Zheng, Y, Clare, R, Fortin, D, Futyan, D, Gary, J, Giunta, M, Hanson, G, Jeng, G, Kao, S, Pasztor, G, Satpathy, A, Shen, B, Stringer, R, Sytnik, V, Wilken, R, Zer Zion, D, Branson, J, Dusinberre, E, Letts, J, Martin, T, Mojaver, M, Paar, H, Pi, H, Pieri, M, Rana, A, Sharma, V, White, A, Wurthwein, F, Affolder, A, Campagnari, C, Hill, C, Incandela, J, Kyre, S, Lamb, J, Richman, J, Stuart, D, White, D, Albert, J, Bornheim, A, Bunn, J, Chen, J, Denis, G, Galvez, P, Gataullin, M, Legrand, I, Litvine, V, Ma, Y, Nae, D, Newman, H, Ravot, S, Shevchenko, S, Singh, S, Steenberg, C, Su, X, Timciuc, V, Van Lingen, F, Veverka, J, Voicu, B, Weinstein, A, Wilkinson, R, Yang, Y, Zhang, L, Zhu, K, Zhu, R, Ferguson, T, Paulini, M, Russ, J, Terentyev, N, Vogel, H, Vorobiev, I, Cumalat, J, Ford, W, Johnson, D, Nauenberg, U, Stenson, K, Wagner, S, Alexander, J, Cassel, D, Ecklund, K, Heltsley, B, Jones, C, Kuznetsov, V, Patterson, J, Ryd, A, Thom, J, Wittich, P, Beetz, C, Cirino, G, Podrasky, V, Sanzeni, C, Winn, D, Abdullin, S, Afaq, M, Albrow, M, Amundson, J, Apollinari, G, Atac, M, Badgett, W, Bakken, J, Baldin, B, Bauerdick, L, Baumbaugh, A, Baur, U, Bhat, P, Borcherding, F, Burkett, K, Butler, J, Cheung, H, Churin, I, Cihangir, S, Demarteau, M, Eartly, D, Elias, J, Elvira, V, Fisk, I, Freeman, J, Gartung, P, Geurts, F, Glenzinski, D, Gottschalk, E, Graham, G, Green, D, Guglielmo, G, Guo, Y, Gutsche, O, Hahn, A, Hanlon, J, Hansen, S, Harris, R, Hesselroth, T, Holm, S, Holzman, B, Iqbal, S, James, E, Johnson, M, Joshi, U, Klima, B, Kowalkowski, J, Kramer, T, Kwan, S, La Vallie, E, Larwill, M, Los, S, Lueking, L, Lukhanin, G, Lusin, S, Maeshima, K, Mcbride, P, Murray, S, O'Dell, V, Paterno, M, Patrick, J, Petravick, D, Pordes, R, Prokofyev, O, Rasmislovich, V, Ratnikova, N, Ronzhin, A, Sekhri, V, Sexton Kennedy, E, Shaw, T, Skow, D, Smith, R, Spalding, W, Spiegel, L, Stavrianakou, M, Stiehr, G, Suzuki, I, Tan, P, Tanenbaum, W, Tkaczyk, S, Veseli, S, Vidal, R, Wenzel, H, Whitmore, J, Womersley, W, Wu, W, Wu, Y, Yagil, A, Yarba, J, Yun, J, Acosta, D, Avery, P, Barashko, V, Bartalini, P, Bourilkov, D, Cavanaugh, R, Drozdetskiy, A, Field, R, Fu, Y, Gray, L, Holmes, D, Kim, B, Klimenko, S, Konigsberg, J, Korytov, A, Kotov, K, Levchenko, P, Madorsky, A, Matchev, K, Mitselmakher, G, Pakhotin, Y, Prescott, C, Ramond, P, Rodriguez, J, Schmitt, M, Scurlock, B, Stoeck, H, Yelton, J, Boeglin, W, Gaultney, V, Kramer, L, Linn, S, Markowitz, P, Martinez, G, Raue, B, Reinhold, J, Askew, A, Bertoldi, M, Dharmaratna, W, Gershtein, Y, Hagopian, S, Hagopian, V, Jenkins, M, Johnson, K, Prosper, H, Wahl, H, Baarmand, M, Baksay, L, Guragain, S, Hohlmann, M, Mermerkaya, H, Ralich, R, Vodopiyanov, I, Adams, M, Betts, R, Gerber, C, Shabalina, E, Smith, C, Ten, T, Akgun, U, Ayan, A, Cooper, A, Debbins, P, Duru, F, Fountain, M, George, N, Mccliment, E, Merlo, J, Mestvirishvili, A, Miller, M, Newsom, C, Norbeck, E, Onel, Y, Schmidt, I, Wang, S, Anderson, E, Atramentov, O, Hauptman, J, Lamsa, J, Barnett, B, Blumenfeld, B, Chien, C, Maksimovic, P, Spangler, S, Swartz, M, Baringer, P, Bean, A, Coppage, D, Grachov, O, Kim, E, Murray, M, Bandurin, D, Bolton, T, Khanov, A, Maravin, Y, Onoprienko, D, Rizatdinova, F, Sidwell, R, Stanton, N, Von Toerne, E, Baden, D, Bard, R, Eno, S, Grassi, T, Hadley, N, Kellogg, R, Kunori, S, Ratnikov, F, Skuja, A, Arcidiacono, R, Ballintijn, M, Bauer, G, Harris, P, Kravchenko, I, Loizides, C, Nahn, S, Paus, C, Pavlon, S, Roland, C, Roland, G, Sumorok, K, Vaurynovich, S, Veres, G, Wyslouch, B, Bailleux, D, Corum, S, Cushman, P, De Benedetti, A, Dolgopolov, A, Egeland, R, Franzoni, G, Gilbert, W, Grahl, J, Haupt, J, Kubota, Y, Mans, J, Pearson, N, Rusack, R, Singovsky, A, Cremaldi, L, Godang, R, Kroeger, R, Sanders, D, Summers, D, Bloom, K, Claes, D, Dominguez, A, Eads, M, Lundstedt, C, Malik, S, Snow, G, Sobol, A, Iashvili, I, Kharchilava, A, Alverson, G, Barberis, E, Boeriu, O, Eulisse, G, Musienko, Y, Muzaffar, S, Osborne, I, Reucroft, S, Swain, J, Taylor, L, Tuura, L, Wood, D, Gobbi, B, Kubantsev, M, Schellman, H, Spencer, E, Velasco, M, Baumbaugh, B, Cason, N, Hildreth, M, Karmgard, D, Marinelli, N, Ruchti, R, Warchol, J, Wayne, M, Bylsma, B, Durkin, L, Gilmore, J, Gu, J, Herman, D, Killewald, P, Knobbe, K, Ling, T, Elmer, P, Marlow, D, Piroue, P, Stickland, D, Tully, C, Wildish, T, Wynhoff, S, Xie, Z, Apresyan, A, Arndt, K, Banicz, K, Barnes, V, Bolla, G, Bortoletto, D, Bujak, A, Garfinkel, A, Lopez, O, Gutay, L, Ippolito, N, Kozhevnikov, Y, Laasanen, A, Liu, C, Maroussov, V, Merkel, P, Miller, D, Miyamoto, J, Neumeister, N, Rott, C, Roy, A, Sedov, A, Shipsey, I, Parashar, N, Eppley, G, Lee, S, Liu, J, Matveev, M, Nussbaum, T, Padley, B, Roberts, J, Tumanov, A, Yepes, P, Bodek, A, Budd, H, Chung, Y, De Barbaro, P, Demina, R, Eusebi, R, Ginther, G, Gotra, Y, Hocker, A, Husemann, U, Korjenevski, S, Sakumoto, W, Slattery, P, Tipton, P, Zielinski, M, Bartz, E, Doroshenko, J, Halkiadakis, E, Jacques, P, Kalelkar, M, Khits, D, Lath, A, Macpherson, A, Perera, L, Plano, R, Rose, K, Schnetzer, S, Somalwar, S, Stone, R, Thomson, G, Watts, T, Akchurin, N, Carrell, K, Gumus, K, Jeong, C, Kim, H, Papadimitriou, V, Sill, A, Spezziga, M, Washington, E, Wigmans, R, Bapty, T, Engh, D, Johns, W, Keskinpala, T, Lopez, E, Neema, S, Nordstrom, S, Pathak, S, Sheldon, P, Vaandering, E, Webster, M, Arenton, M, Conetti, S, Cox, B, Hirosky, R, Imlay, R, Ledovskoy, A, Phillips, D, Powell, H, Ronquest, M, Smith, D, Baek, Y, Bellinger, J, Bradley, D, Carlsmith, D, Crotty, I, Dasu, S, Feyzi, F, Gorski, T, Grothe, M, Hogg, W, Jaworski, M, Klabbers, P, Lanaro, A, Loveless, R, De Abril, M, Reeder, D, Smith, W, Wenman, D, Atoyan, G, Dhawan, S, Issakov, V, Neal, H, Poblaguev, A, Zeller, M, Yuldashev, B, TR1918, Demir, Durmuş Ali, Izmir Institute of Technology. Physics, Çukurova Üniversitesi, Fen-Edebiyat Fakültesi, Fizik Bölümü, and Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Physics beyond the Standard Model, Large Hadron Collider (LHC), 01 natural sciences, 7. Clean energy, HIGGS-BOSON PRODUCTION, TO-LEADING-ORDER, PRODUCTION CROSS-SECTION, LARGE HADRON COLLIDER, SUPERSYMMETRIC STANDARD MODEL, ELECTROWEAK SYMMETRY-BREAKING, LARGE TRANSVERSE-MOMENTUM, B-C MESON, SUPERCONDUCTING SUPER COLLIDER, SOFTLY BROKEN SUPERSYMMETRY, Vector boson, Settore FIS/04 - Fisica Nucleare e Subnucleare, PARTICLE PHYSICS, CMS, Energy density, technical design report, CERN, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Physics, Large Hadron Collider, Settore FIS/01 - Fisica Sperimentale, Supersymmetry, Physics and Astronomy (all), Nuclear and High Energy Physics, FIS/01 - FISICA SPERIMENTALE, High-density QCD matter, Higgs boson, CMS, LHC, Physics, particles, Higgs, particle physics, detector, accelerator, Particle physics, Standard Model, Settore FIS/03 - Fisica della Materia, Nuclear physics, 0103 physical sciences, 010306 general physics, Settore MAT/07 - Fisica Matematica, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Little Higgs, pp, LHC, Higgs, supersymmetry, heavy ion, High Energy Physics::Experiment, CERN Large Hadron Collider (LHC), Parton momentum fraction, Minimal Supersymmetric Standard Model
Abstract: CMS is a general purpose experiment, designed to study the physics of pp collisions at 14 TeV at the Large Hadron Collider (LHC). It currently involves more than 2000 physicists from more than 150 institutes and 37 countries. The LHC will provide extraordinary opportunities for particle physics based on its unprecedented collision energy and luminosity when it begins operation in 2007. The principal aim of this report is to present the strategy of CMS to explore the rich physics programme offered by the LHC. This volume demonstrates the physics capability of the CMS experiment. The prime goals of CMS are to explore physics at the TeV scale and to study the mechanism of electroweak symmetry breaking - through the discovery of the Higgs particle or otherwise. To carry out this task, CMS must be prepared to search for new particles, such as the Higgs boson or supersymmetric partners of the Standard Model particles, from the start-up of the LHC since new physics at the TeV scale may manifest itself with modest data samples of the order of a few fb-1 or less. The analysis tools that have been developed are applied to study in great detail and with all the methodology of performing an analysis on CMS data specific benchmark processes upon which to gauge the performance of CMS. These processes cover several Higgs boson decay channels, the production and decay of new particles such as Z′ and supersymmetric particles, Bs production and processes in heavy ion collisions. The simulation of these benchmark processes includes subtle effects such as possible detector miscalibration and misalignment. Besides these benchmark processes, the physics reach of CMS is studied for a large number of signatures arising in the Standard Model and also in theories beyond the Standard Model for integrated luminosities ranging from 1 fb-1 to 30 fb-1. The Standard Model processes include QCD, B-physics, diffraction, detailed studies of the top quark properties, and electroweak physics topics such as the W and Z0 boson properties. The production and decay of the Higgs particle is studied for many observable decays, and the precision with which the Higgs boson properties can be derived is determined. About ten different supersymmetry benchmark points are analysed using full simulation. The CMS discovery reach is evaluated in the SUSY parameter space covering a large variety of decay signatures. Furthermore, the discovery reach for a plethora of alternative models for new physics is explored, notably extra dimensions, new vector boson high mass states, little Higgs models, technicolour and others. Methods to discriminate between models have been investigated. This report is organized as follows. Chapter 1, the Introduction, describes the context of this document. Chapters 2-6 describe examples of full analyses, with photons, electrons, muons, jets, missing E T, B-mesons and τ's, and for quarkonia in heavy ion collisions. Chapters 7-15 describe the physics reach for Standard Model processes, Higgs discovery and searches for new physics beyond the Standard Model. © 2007 IOP Publishing Ltd.
Published: 2007
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34. The CMS Simulation Software

Author: R. Wilkinson, Jim Kowalkowski, A. Yagil, Nicola Amapane, Fabrizio Ferro, M. Stavrianakou, D. Elvira, Kati Lassila-Perini, J. Yarba, Elizaveta Shabalina, C. D. Jones, C. Charlor, Alexander Nikitenko, I. Osborne, E. Garcia, Panagiotis Katsas, S. Ashby, Pietro Govoni, S. Piperov, Peter Elmer, A. Zhokin, A. Rizzi, J. Weng, P. Arce, Vincenzo Innocente, Paolo Meridiani, S. Abdouline, M. Paterno, S. Banerjee, X. T. Huang, U. Berthon, Maria Spiropulu, T. Cox, Filip Moortgat, Avto Kharchilava, D. Onoprienko, Elizabeth Sexton-Kennedy, M. Case, N. Darmenov, F. Ambroglini, Oliver Gutsche, Tommaso Boccali, M. Pioppi, David Evans, A. De Roeck, W. Tanenbaum, Suchandra Dutta, M. Strang, Lucia Silvestris, S. Magni, and Harry Cheung
Subjects: Physics, Robustness (computer science), Physics::Instrumentation and Detectors, On demand, Suite, Detector, Dynamical simulation, CASTOR calorimeter, computer.software_genre, computer, Simulation, Digitization, Simulation software
Abstract: In this paper we present the features and the expected performance of the re-designed CMS simulation software, as well as the experience from the migration process. Today, the CMS simulation suite is based on the two principal components - Geant4 detector simulation toolkit and the new CMS offline Framework and Event Data Model. The simulation chain includes event generation, detector simulation, and digitization steps. With Geant4, we employ the full set of electromagnetic and hadronic physics processes and detailed particle tracking in the 4 Tesla magnetic field. The Framework provides "action on demand" mechanisms, to allow users to load dynamically the desired modules and to configure and tune the final application at the run time. The simulation suite is used to model the complete central CMS detector (over 1 million of geometrical volumes) and the forward systems, such as Castor calorimeter and Zero Degree Calorimeter, the Totem telescopes, Roman Pots, and the Luminosity Monitor. The designs also previews the use of the electromagnetic and hadronic showers parametrization, instead of full modelling of high energy particles passage through a complex hierarchy of volumes and materials, allowing significant gain in speed while tuning the simulation to test beam and collider data. Physics simulation has been extensively validated by comparison with test beam data and previous simulation results. The redesigned and upgraded simulation software was exercised for performance and robustness tests. It went into Production in July 2006, running in the US and EU grids, and has since delivered about 60 millions of events.
Published: 2006

35. Statistical analysis of correlations and intermittency of a turbulent rotating column in a magnetoplasma device

Author: Ruggero Barni, S. Magni, Cristina Riccardi, Th. Pierre, H. E. Roman, D. Guyomarc’h, Institut de Recherche en Horticulture et Semences (IRHS), AGROCAMPUS OUEST-Institut National de la Recherche Agronomique (INRA)-Université d'Angers (UA), Università degli Studi di Milano-Bicocca, Dipartimento di Scienza dei Materiali, Via Cozzi 53, I-20125 Milano, Italie, Physique des interactions ioniques et moléculaires (PIIM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Fisica [Milano-Bicocca], Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB), Institut de Recherche sur la Fusion par confinement Magnétique (IRFM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Università degli Studi di Milano-Bicocca [Milano] (UNIMIB), Université d'Angers (UA)-Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Dipartimento di Scienza dei Materiali = Department of Materials Science [Milano-Bicocca], Magni, S, Roman, H, Barni, R, Riccardi, C, Pierre, T, Guyomarc'H, D, and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)
Subjects: Probability density function, 01 natural sciences, 010305 fluids & plasmas, law.invention, law, Physics::Plasma Physics, [PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph], Intermittency, 0103 physical sciences, Limiter, Statistical physics, 010306 general physics, magnetoplasma turbulence intermittency, FIS/03 - FISICA DELLA MATERIA, ComputingMilieux_MISCELLANEOUS, Physics, PACS: 52.35Ra, 52.35Gj, waves and instabilities, Turbulence, turbulence, [SPI.PLASMA]Engineering Sciences [physics]/Plasmas, Mechanics, Plasma, Distribution function, FIS/01 - FISICA SPERIMENTALE, Exponent, Coherence (physics)
Abstract: A statistical analysis of density fluctuations in a cylindrical non-fusion device is performed. The experimental set-up is implemented in order to reach a turbulent behavior of the linear plasma column. Two different turbulent regimes are obtained corresponding to two selected sets of values for the discharge parameters. The first regime displays a rotating column characterized by the presence of a shear layer separating the plasma bulk from the tenuous plasma in the shadow of the limiter, the latter showing a strong intermittent behavior and superdiffusion. The second regime corresponds to a weakly-rotating column in which coherence is lost in the plasma bulk and a standard diffusive process takes place in the shadow region. These findings are supported by the calculation of the Hurst¿s exponent using Wavelet-analysis techniques. Furthermore the intermittent behavior is characterized and related to the diffusive process. Finally the shape of the probability distribution function (PDF) of density fluctuations seems to be well described by an analytical form suggested on the basis of a generalized statistics.
Published: 2005
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36. Active sites in the alkylation of toluene with methanol : a study by selective acid-base poisoning

Author: A. Borgna, Carlos Rodolfo Apesteguia, S. Magni, and Jorge Sepúlveda
Subjects: Chemistry, Process Chemistry and Technology, Inorganic chemistry, Alkylation, Ethylbenzene, Toluene, Medicinal chemistry, Catalysis, Styrene, chemistry.chemical_compound, Pyridine, Methanol, Lewis acids and bases
Abstract: Selective acid–base poisoning of the alkylation of toluene with methanol was studied over alkali and alkaline-earth exchanged Y zeolites. Surface acid–base properties of the samples were determined by infrared spectroscopy using carbon dioxide and pyridine as probe molecules. Selective poisoning experiments were performed by co-feeding either acetic acid or 3,5-dimethyl pyridine. Kinetic deactivation parameters were determined by modeling experimental data with a deactivation model with residual activity (DMRA). MgY produced essentially xylenes and alkylated C9+ compounds. This zeolite was deactivated only by co-feeding 3,5-dimethyl pyridine, thereby indicating that exclusively acid sites are involved in the ring alkylation of toluene with methanol. In contrast, zeolite CsY formed mainly styrene and ethylbenzene, and was strongly deactivated by the addition of either acid or base compounds. Infrared characterization showed that zeolite CsY contains Lewis acid (Cs+)–base (O2−) pairs capable of adsorbing bidentate carbonates but does not exhibit Bronsted acidity. Thus, selective poisoning results and sample characterization showed that bimolecular side-chain alkylation reaction on CsY requires a specific surface acid–base pairs configuration not only for activating toluene and methanol, but also for promoting the rate-limiting step.
Published: 2004

37. Statistical investigation of transport barrier effects produced by biasing in a nonfusion magnetoplasma

Author: H. E. Roman, Cristina Riccardi, S. Magni, Magni, S, Riccardi, C, and Roman, H
Subjects: Radial velocity, Shearing (physics), Physics, Magneto-Plasma fluctuations, long-range correlations, Hurst exponent, Condensed matter physics, Electric field, Limiter, Probability density function, Biasing, Plasma, Condensed Matter Physics, Particle density, Computational physics
Abstract: The effects of a biasing potential on the statistical properties of the fluctuating flux, particle density and radial velocity time series in the nonfusion magnetoplasma Thorello [C. Riccardi, D. Xuantong, M. Salierno, L. Gamberale, and M. Fontanesi, Phys. Plasmas 4, 3749 (1997)] are studied. The shape evolution of the probability distribution function (PDF) of the temporal coarse-grained fluctuating flux is investigated as a function of the radial position in the plasma equatorial plane, for different values of the bias potential applied to a limiter. A reduction of cross correlations between density and radial velocity, concomitant with an increase in the shearing rate of the radial electric field, is found near the center of the plane as a function of the bias potential. The partial density-velocity cross correlations, evaluated at different time scales, reach their asymptotic values for times of the order of those describing the change in shape of the fluctuating flux PDF. The magnitude of the shearing rate of the radial electric field, calculated at different radial positions in the plane, is consistent with the expected decorrelation mechanism of turbulent transport. (C) 2004 American Institute of Physics.
Published: 2004

38. Unilateral destructice wrist synovitis in juvenile idiopathic arthritis

Author: R, Cassone, A, Falcone, F, Rossi, S, Magni-Manzoni, E, Felici, A, Buoncompagni, A, Martini, and A, Ravelli
Subjects: Radiography, Wrist Joint, Synovitis, Child, Preschool, Humans, Infant, Female, Child, Arthritis, Juvenile, Follow-Up Studies, Retrospective Studies
Abstract: To describe the clinical and radiographic features of a group of juvenile idiopathic arthritis (JIA) patients who developed unilateral destructive wrist synovitis.All wrist radiographs performed yearly between 1986 and 2002 in JIA patients who had wrist involvement were retrospectively reviewed to identify patients who had unilateral erosive wrist synovitis, defined as a difference of at least -3 units in the Poznanski score between the affected wrist and the unaffected wrist, with the Poznanski score in the unaffected wrist being-2 units throughout the follow-up period. Clinical and radiographic data obtained during follow-up were recorded for all patients.Of a total of 250 patients for whom we had approximately 900 wrist radiographs, 6 patients were found to have unilateral erosive wrist synovitis. The JIA onset subtype was oligoarticular in 5 patients and polyarticular in 1 patient and the disease duration from presentation to the last follow-up visit ranged from 2 to 16 years. The arthritis course was polyarticular in all patients. Five patients had positive antinuclear antibodies (ANA) and 1 had positive rheumatoid factor (RF). At the last follow-up visit, all patients had some impairment of wrist function and 2 patients had wrist subluxation. There was a marked radiographic damage in all affected wrist, with the Poznanski ranging from -8.0 to -8.50 units in 3 patients and being -5.5, -3.1 and -2.4 units, respectively, in 3 patients. The severity of radiographic damage in the ANA-positive patients with the longest disease duration was comparable to that observed in the RF-positive patient.Unilateral erosive wrist synovitis seems to be uncommon in JIA. Patients with unilateral wrist synovitis may be at risk of a destructive course irrespective of the JIA onset subtype.
Published: 2004

39. Database requirements for the Inner Silicon Tracker in BTeV

Author: S. Magni and D. Menasce
Abstract: Database requirements for the Inner Silicon Tracker in BTeV
Published: 2003
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40. Update on POMONE

Author: S. Magni, D. Menasce, and L. Uplegger
Subjects: Physics::Instrumentation and Detectors, High Energy Physics::Phenomenology, Astrophysics::Instrumentation and Methods for Astrophysics, Physics::Accelerator Physics, High Energy Physics::Experiment
Abstract: POMONE: the Pixel Telescope Read-out system for the FNAL Meson Area test-beam
Published: 2003
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41. Proposal for a Geometry Manager based upon GDML

Author: G. Cerati, S. Magni, and D. Menasce
Abstract: Proposal for a Geometry Manager based upon GDML
Published: 2003
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42. Il DAQ dei pixel per il fascio di test di BTeV

Author: S. Magni, D. Menasce, and L. Uplegger
Abstract: Il DAQ dei pixel per il fascio di test di BTeV
Published: 2003
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43. Status of the pixel read-out code (POMONE)

Author: G. Chiodini, B. Hall, S. Magni, D. Menasce, L. Uplegger, and D. Zhang
Subjects: Physics::Instrumentation and Detectors, High Energy Physics::Phenomenology, Astrophysics::Instrumentation and Methods for Astrophysics, Physics::Accelerator Physics, High Energy Physics::Experiment
Abstract: POMONE: the read-out code of the pixel telescope of the FNAL Meson Area test-beam.
Published: 2003
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44. Proposal for a Simulation Framework in BTeV

Author: G. Cerati, E. Di Maio, S. Magni, and D. Menasce
Abstract: Proposal for a Simulation Framework in BTeV
Published: 2003
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45. GEANT4 TRACING TESTs

Author: D. Lunesu, S. Magni, and D. Menasce
Abstract: Tests of the GEANT4 tracing performances in GEANT4 for the BTeV tracking simulation
Published: 2003
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46. Pomone, a PCI based data acquisition system

Author: B.K. Hall, G. Alimonti, Dario Menasce, S. Magni, Gabriele Chiodini, Lorenzo Uplegger, and D. Zhang
Subjects: Modularity (networks), Pixel, Physics::Instrumentation and Detectors, business.industry, Computer science, High Energy Physics::Phenomenology, Detector, Context (language use), Continuous mode, Set (abstract data type), Computer Science::Hardware Architecture, Data acquisition, Physics::Accelerator Physics, High Energy Physics::Experiment, business, Computer hardware, Graphical user interface
Abstract: Pomone is a flexible read-out system, designed in the context of the BTeV pixel test beam, based upon a PCI-compliant board and a custom-built mezzanine card to accommodate different detector front-end components. The system consists of a rich set of C++ classes to provide the backbone functionalities needed to readout a pixel detector in a continuous mode, and a collection of GUIs to allow users to interact with all the hardware components. The system has been designed with a high level of generality in order to accommodate different kind of detectors as well as different event-building strategies. A detailed description of the system, running under the Linux platform, is provided, along with a discussion of specific solutions adopted to meet the requirements of efficiency and modularity posed by the design.
Published: 2003
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47. Status of the Test-Beam DAQ System

Author: G. Chiodini, S. Magni, D. Menasce, L. Uplegger, and D. Zhang
Subjects: Physics::Instrumentation and Detectors, High Energy Physics::Phenomenology, Astrophysics::Instrumentation and Methods for Astrophysics, Physics::Accelerator Physics, High Energy Physics::Experiment
Abstract: An update on the FNAL Meson Area Pixel telescope test-beam
Published: 2002
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48. The XML approach for the DAQ initialization files (plus an update on the status of the DAQ project)

Author: G. Chiodini, S. Magni, D. Menasce, L. Uplegger, and D. Zhang
Subjects: ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Abstract: The XML approach for the DAQ initialization files (plus an update on the status of the DAQ project)
Published: 2002
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49. Combination therapy with methotrexate and cyclosporine A in juvenile idiopathic arthritis

Author: A, Ravelli, C, Moretti, F, Temporini, F, Rossi, S, Magni-Manzoni, A, Pistorio, and A, Martini
Subjects: Male, Methotrexate, Treatment Outcome, Adolescent, Antirheumatic Agents, Child, Preschool, Cyclosporine, Administration, Oral, Humans, Drug Therapy, Combination, Female, Child, Arthritis, Juvenile
Abstract: To investigate the efficacy and safety of a combination therapy with methotrexate (MTX) and cyclosporine A (CyA) in patients with juvenile idiopathic arthritis (JIA) who were refractory to MTX as a single second-line agent.Seventeen consecutive patients with JIA who had refractory polyarthritis despite a minimum of 6 months of MTX as a single second-line agent at the dose of 15 to 25 mg/m2/week were continued with MTX with the addition of CyA (4 mg/kg/day) for 6 to 30 months (median 10 months) were analyzed. The clinical response to therapy was assessed through the preliminary definition of improvement in JIA.At the end of the treatment, as compared to the time when CyA was added to MTX, 8 patients (47%) met the 30% definition of improvement; among them 5 (29%) met the 70% definition of improvement, and 2 (12%) achieved complete disease control. Seven patients (41%) experienced side effects: 4 gastrointestinal discomfort, 1 liver transaminase elevation, and 2 increaseor = 30% in the serum creatinine concentration. No patients was discontinued from combination therapy due to adverse events.In our JIA patients who were refractory to MTX as a single second-line agent, the addition of CyA was associated with a significant clinical improvement in roughly half of the patients.
Published: 2002

50. Influence of dietary conjugated linoleic acids (CLA) and age at slaughtering on meat quality and intramuscular collagen in rabbits

Author: Grazia Pastorelli, Giuseppe Maiorano, Angelo Manchisi, Carlo Corino, Raffaella Rossi, Federica Filetti, S. Magni, and M. Gambacorta
Subjects: chemistry.chemical_classification, collagen, food.ingredient, Fat content, Conjugated linoleic acid, Linoleic acid, Sunflower oil, rabbit, food and beverages, Biology, conjugated linoleic acid, Tenderness, chemistry.chemical_compound, meat, food, nutrition, chemistry, medicine, Composition (visual arts), New zealand white, Food science, medicine.symptom, Food Science, Polyunsaturated fatty acid
Abstract: To assess the effects of dietary conjugated linoleic acids (CLA) on meat composition and intramuscular collagen (IMC), 144 New Zealand White rabbits, half males half females, 55 days old (1.8 kg LW), were assigned to three weight- and sex- balanced groups and given the following dietary supplements: 0.5% sunflower oil, (C); 0.25% sunflower oil plus 0.25% CLA (T1); and 0.5% CLA (T2). The CLA was prepared from sunflower oil and contained 65% CLA isomers, half cis-9, trans-11 and half trans-10, cis-12. Six males and six females from each group (total 36) were slaughtered at 76, 90 and 104 days of age (corresponding to 2.5, 2.8, and 3.1 kg BW, respectively). The lean fraction was higher and the water content significantly higher in the meat of T2 compared to C and T1 for all ages combined. At the third slaughtering (104 days) the meat fat content was significantly lower in group T2. For all ages combined, IMC content, IMC hydroxylysylpyridinoline (HLP) concentration (index of collagen cross-linking) and IMC maturity (HLP/IMC) were significantly lower in the intermediate supplementation group (T1) compared to C and T2, and were also lower in animals slaughtered at 90 days. CLA supplementation has limited effects on the chemical composition of rabbit meat, with positive effects on meat texture and tenderness after supplementation up to 35 days at 0.25%, and a significant decrease in fat content only at high slaughter weight and high supplementation level (0.5%).
Published: 2002

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